Detailed information for compound 1723068

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 627.731 | Formula: C38H37N5O4
  • H donors: 3 H acceptors: 5 LogP: 6.63 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C(NC(=O)c1ccc2c(c1)n(C)c(c2C1CCCC1)c1cccc2c1nccc2)(C)C)Nc1ccc2c(c1)cc(n2C)C(=O)O
  • InChi: 1S/C38H37N5O4/c1-38(2,37(47)40-26-15-17-29-25(19-26)21-31(36(45)46)42(29)3)41-35(44)24-14-16-27-30(20-24)43(4)34(32(27)22-9-5-6-10-22)28-13-7-11-23-12-8-18-39-33(23)28/h7-8,11-22H,5-6,9-10H2,1-4H3,(H,40,47)(H,41,44)(H,45,46)
  • InChiKey: CKXPHHMSDDZCGY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.022 0.4658 0.6637
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0029 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.5739 1
Echinococcus multilocularis zinc finger protein 0.0023 0.0253 0.036
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0033 0.0467 0.0767
Brugia malayi PHD-finger family protein 0.0029 0.0372 0.06
Loa Loa (eye worm) oxidoreductase 0.0033 0.0467 0.0627
Loa Loa (eye worm) hypothetical protein 0.0038 0.059 0.0802
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0467 0.0666
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0294 0.0464
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0114 0.0162
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0467 0.0666
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3673 0.6247
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0084 0.0096
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0294 0.0419
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0235 0.0294
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0033 0.0467 0.3105
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0777 0.4905
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0294 0.0464
Onchocerca volvulus 0.0033 0.0467 0.0512
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0574 0.0818
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0153 0.3156 0.4497
Echinococcus granulosus hypothetical protein 0.0033 0.0467 0.0666
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0467 0.0666
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0033 0.0467 0.0422
Trypanosoma brucei aldo-keto reductase, putative 0.0033 0.0467 0.3105
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.5739 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0379
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.134 0.2295
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0294 0.0419
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.3885 0.6633
Toxoplasma gondii aldose reductase, putative 0.0033 0.0467 0.2104
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0329 0.2321
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0286 0.1672
Entamoeba histolytica hypothetical protein 0.0025 0.0286 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3673 0.6247
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.022 0.4658 0.6637
Brugia malayi RNA, U transporter 1 0.0087 0.1673 0.2879
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.021 0.0258
Schistosoma mansoni zinc finger protein 0.0023 0.0253 0.036
Mycobacterium ulcerans hypothetical protein 0.0072 0.134 1
Brugia malayi MH2 domain containing protein 0.0119 0.2393 0.4141
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0574 0.0818
Loa Loa (eye worm) hypothetical protein 0.0034 0.0492 0.0662
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.134 0.0915
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0467 0.0422
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0467 0.0422
Brugia malayi Bromodomain containing protein 0.0042 0.0671 0.1124
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0492 0.081
Schistosoma mansoni hypothetical protein 0.0326 0.7018 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.134 1
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.5739 1
Brugia malayi Bromodomain containing protein 0.0079 0.1491 0.2561
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0236 0.0337
Echinococcus granulosus zinc finger protein 0.0023 0.0253 0.036
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3673 0.6247
Entamoeba histolytica hypothetical protein 0.022 0.4658 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0574 0.0818
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0029 0.0042
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0084 0.012
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0294 0.0464
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0415 0.1631
Schistosoma mansoni hypothetical protein 0.0176 0.3662 0.5219
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0379
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0294 0.0464
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0329 0.0854
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0379
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0286 0.0093
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0294 0.0419
Schistosoma mansoni hypothetical protein 0.0016 0.0084 0.012
Leishmania major importin beta-1 subunit, putative 0.0025 0.0286 0.1672
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0294 0.0419
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0294 0.0419
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.134 0.0915
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.134 0.0915
Loa Loa (eye worm) hypothetical protein 0.0044 0.0725 0.0996
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0294 0.0419
Echinococcus granulosus snurportin 1 0.0326 0.7018 1
Schistosoma mansoni transcription factor LCR-F1 0.022 0.4658 0.6637
Leishmania major prostaglandin f synthase, putative 0.0033 0.0467 0.3105
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.5739 1
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0641 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0294 0.0379
Loa Loa (eye worm) hypothetical protein 0.0031 0.0415 0.0552
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0574 0.3951
Schistosoma mansoni ran 0.0022 0.0235 0.0334
Giardia lamblia Aldose reductase 0.0033 0.0467 0.5719
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.134 0.2007
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0033 0.0467 0.0767
Entamoeba histolytica aldose reductase, putative 0.0033 0.0467 0.0525
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0467 0.0666
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0415 0.2692
Onchocerca volvulus 0.0033 0.0467 0.0512
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0033 0.0467 0.1961
Schistosoma mansoni hypothetical protein 0.0196 0.4121 0.5872
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.134 0.0915
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0467 0.0666
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.134 0.0915
Mycobacterium tuberculosis Conserved protein 0.0072 0.134 0.0915
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0574 0.0617
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0294 0.0464
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0535 0.0763
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0574 0.0818
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0235 0.1268
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0235 0.1268
Trichomonas vaginalis aldo/keto reductase, putative 0.0033 0.0467 0.0422
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0467 0.0666
Schistosoma mansoni coup transcription factor 0.0025 0.0294 0.0419
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0294 0.0464
Schistosoma mansoni aldo-keto reductase 0.0033 0.0467 0.0666
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0294 0.0379
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0467 0.0422
Brugia malayi hypothetical protein 0.0027 0.0329 0.0525
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.134 0.1909
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0236 0.0337
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.134 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0294 0.0419
Onchocerca volvulus 0.0072 0.134 0.3093
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0294 0.0419
Echinococcus granulosus importin subunit beta 1 0.0031 0.0415 0.0591
Brugia malayi beta-lactamase family protein 0.0072 0.134 0.2295
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0843 0.1426
Loa Loa (eye worm) hypothetical protein 0.0046 0.0768 0.1057
Echinococcus granulosus aldehyde reductase 0.0023 0.0254 0.0362
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0084 0.0096
Echinococcus multilocularis kelch ECH associated protein 1 0.0196 0.4109 0.5854
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.5739 0.8169
Echinococcus granulosus aldo keto reductase 0.0033 0.0467 0.0666
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0294 0.0464
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0467 0.0666
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0294 0.0379
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0843 0.1165
Loa Loa (eye worm) hypothetical protein 0.0027 0.0329 0.0429
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0467 0.0666
Brugia malayi acetyltransferase, GNAT family protein 0.0153 0.3156 0.5477
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0329 0.0854
Schistosoma mansoni importin beta-1 0.0031 0.0415 0.0591
Trichomonas vaginalis aldo/keto reductase, putative 0.0033 0.0467 0.0422
Leishmania major hypothetical protein, conserved 0.0072 0.134 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0033 0.0467 0.3105
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.134 0.1909
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0415 0.2692
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0294 0.0419
Schistosoma mansoni ran 0.0022 0.0235 0.0334
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0777 0.0985
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0084 0.012
Mycobacterium ulcerans beta-lactamase 0.0072 0.134 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0114 0.0162
Loa Loa (eye worm) hypothetical protein 0.0072 0.134 0.1875
Plasmodium vivax hypothetical protein, conserved 0.0072 0.134 1
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.134 0.0915
Trypanosoma brucei prostaglandin f synthase 0.0033 0.0467 0.3105
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0033 0.0467 0.0422
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0574 0.0617
Schistosoma mansoni hypothetical protein 0.0015 0.0074 0.0106
Schistosoma mansoni hypothetical protein 0.0016 0.0084 0.012
Echinococcus multilocularis aldehyde reductase 0.0023 0.0254 0.0362
Loa Loa (eye worm) oxidoreductase 0.0033 0.0467 0.0627
Echinococcus granulosus geminin 0.0176 0.3662 0.5219
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0294 0.0419
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0777 0.4905
Echinococcus multilocularis kelch ECH associated protein 1 0.0196 0.4109 0.5854
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.134 0.2007
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0467 0.0422
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3673 0.6247
Giardia lamblia Aldose reductase 0.0033 0.0467 0.5719
Echinococcus granulosus aldo keto reductase 0.0033 0.0467 0.0666
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.5739 1
Plasmodium vivax importin-beta 2, putative 0.0031 0.0415 0.1631
Loa Loa (eye worm) hypothetical protein 0.0072 0.134 0.1875
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0294 0.0464
Schistosoma mansoni hypothetical protein 0.0034 0.0492 0.0701
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0574 0.3951
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0379
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0294 0.0419
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0235 0.036
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.3673 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0641 0.0919
Onchocerca volvulus 0.0033 0.0467 0.0512
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0235 0.0334
Loa Loa (eye worm) hypothetical protein 0.0038 0.0574 0.078
Loa Loa (eye worm) oxidoreductase 0.0033 0.0467 0.0627
Schistosoma mansoni bromodomain containing protein 0.0067 0.1229 0.1752
Loa Loa (eye worm) oxidoreductase 0.0033 0.0467 0.0627
Trichomonas vaginalis aldo/keto reductase, putative 0.0033 0.0467 0.0422
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0467 0.0422
Toxoplasma gondii ABC1 family protein 0.0072 0.134 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.1149 0.1638
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0033 0.0467 0.0422
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0294 0.0419
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.134 1
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0294 0.0464
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0294 0.0419
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.1149 0.1638
Echinococcus granulosus kelch ECH associated protein 1 like 0.0196 0.4109 0.5854
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0294 0.0379
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0294 0.0464
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0574 0.0818
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0467 0.0422
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0033 0.0467 0.0767
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0114 0.0162
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0286 0.0093
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.134 0.2007
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.134 0.1875
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0467 0.0666
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.134 1
Trypanosoma cruzi aldo-keto reductase 0.0033 0.0467 0.3105
Loa Loa (eye worm) hypothetical protein 0.0017 0.0114 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0294 0.0464
Mycobacterium leprae conserved hypothetical protein 0.0072 0.134 1
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0294 0.0419
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0379
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0467 0.0422
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0294 0.0419
Mycobacterium tuberculosis Conserved protein 0.0072 0.134 0.0915
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0294 0.0419
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0235 0.1268
Onchocerca volvulus 0.0033 0.0467 0.0512
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0294 0.0419
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0294 0.0379
Schistosoma mansoni hypothetical protein 0.0021 0.0194 0.0276
Loa Loa (eye worm) beta-lactamase 0.0072 0.134 0.1875
Echinococcus granulosus kelch ECH associated protein 1 like 0.0196 0.4109 0.5854
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0114 0.0162
Echinococcus multilocularis aldo keto reductase 0.0033 0.0467 0.0666
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0326 0.7018 1
Schistosoma mansoni hypothetical protein 0.0176 0.3662 0.5219
Leishmania major GTP-binding protein, putative 0.0022 0.0235 0.1268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0294 0.0379
Echinococcus multilocularis aldo keto reductase 0.0033 0.0467 0.0666
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0467 0.0666
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0294 0.0419
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0467 0.0666
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0294 0.0464
Trichomonas vaginalis esterase, putative 0.0072 0.134 0.2007
Echinococcus multilocularis aldo keto reductase 0.0033 0.0467 0.0666
Echinococcus granulosus aldo keto reductase 0.0033 0.0467 0.0666
Entamoeba histolytica aldose reductase, putative 0.0033 0.0467 0.0525
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0574 0.0818
Plasmodium falciparum importin beta, putative 0.0031 0.0415 0.4434
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.134 0.1909
Leishmania major hypothetical protein, conserved 0.0027 0.0329 0.2013
Mycobacterium ulcerans lipase LipD 0.0072 0.134 1
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2393 0.3383
Echinococcus multilocularis aldo keto reductase 0.0033 0.0467 0.0666
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0033 0.0467 0.3105
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0329 0.2321
Loa Loa (eye worm) hypothetical protein 0.0016 0.0084 0.0078
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0467 0.0666
Brugia malayi follicle stimulating hormone receptor 0.0236 0.5005 0.8714
Loa Loa (eye worm) hypothetical protein 0.0033 0.0467 0.0627
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0777 0.4905
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0294 0.0464
Schistosoma mansoni aldo-keto reductase 0.0033 0.0467 0.0666
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0114 0.0162
Schistosoma mansoni hypothetical protein 0.0016 0.0084 0.012
Loa Loa (eye worm) acetyltransferase 0.0153 0.3156 0.4474
Entamoeba histolytica hypothetical protein 0.022 0.4658 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2393 0.3383
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3673 0.6247
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0294 0.0464
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0777 0.0985
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0467 0.0666
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0294 0.0419
Onchocerca volvulus 0.0033 0.0467 0.0512
Echinococcus multilocularis Kelch repeat type 1 0.0196 0.4121 0.5872
Brugia malayi hypothetical protein 0.022 0.4658 0.8108
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0294 0.0419
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.3009 0.4287
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0574 0.0767
Loa Loa (eye worm) hypothetical protein 0.0072 0.134 0.1875
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.5739 1
Brugia malayi nuclear hormone receptor 0.0025 0.0294 0.0464
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.134 0.2007
Echinococcus multilocularis GPCR, family 2 0.0016 0.0084 0.012
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.022 0.4658 0.6637
Brugia malayi ecdysteroid receptor 0.0025 0.0294 0.0464
Mycobacterium tuberculosis Conserved protein 0.0072 0.134 0.0915
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0574 0.0617
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0574 0.8353
Entamoeba histolytica hypothetical protein 0.022 0.4658 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.134 0.1875
Loa Loa (eye worm) hypothetical protein 0.005 0.0843 0.1165
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0084 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.134 1
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.3885 0.6633
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0379
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0194 0.0235
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0294 0.0419
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0467 0.0422
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0467 0.0422
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0467 0.0666
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0467 0.0666
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0415 0.0591
Entamoeba histolytica aldose reductase, putative 0.0033 0.0467 0.0525
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0329 0.2013
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0467 0.0422
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0294 0.0419
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0084 0.012
Brugia malayi beta-lactamase 0.0072 0.134 0.2295
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.5739 1
Echinococcus granulosus kelch ECH associated protein 1 0.0196 0.4109 0.5854
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0467 0.0666
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0329 0.2013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0843 0.1426
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0467 0.0422
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0574 0.0818
Echinococcus multilocularis geminin 0.0176 0.3662 0.5219
Brugia malayi hypothetical protein 0.0017 0.0118 0.0155
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0467 0.0666
Loa Loa (eye worm) hypothetical protein 0.0072 0.134 0.1875
Schistosoma mansoni hypothetical protein 0.0016 0.0084 0.012
Echinococcus multilocularis snurportin 1 0.0326 0.7018 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0294 0.0379
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3673 0.6247
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0084 0.0078
Schistosoma mansoni zinc finger protein 0.0015 0.0074 0.0106
Trichomonas vaginalis aldo-keto reductase, putative 0.0033 0.0467 0.0422
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0294 0.0419
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0294 0.0419
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0379
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0294 0.0419
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0029 0.0042
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0294 0.0419
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0777 0.1107
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0294 0.0419
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0574 0.3951
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0294 0.0419
Leishmania major aldo-keto reductase-like protein 0.0033 0.0467 0.3105
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.5005 0.7119
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.134 0.0915
Loa Loa (eye worm) hypothetical protein 0.0072 0.134 0.1875
Loa Loa (eye worm) hypothetical protein 0.0025 0.0294 0.0379
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0641 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0574 0.3951
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.134 0.2007
Onchocerca volvulus 0.0072 0.134 0.3093
Brugia malayi Importin beta-1 subunit 0.0031 0.0415 0.0675
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0294 0.0419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0294 0.0379
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0029 0.0042
Loa Loa (eye worm) oxidoreductase 0.0033 0.0467 0.0627
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0235 0.0334
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0114 0.0162
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0033 0.0467 0.0767
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0574 0.0818
Brugia malayi steroid hormone receptor 0.0025 0.0294 0.0464
Onchocerca volvulus 0.0033 0.0467 0.0512
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0114 0.0162
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0153 0.3156 0.4497
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0467 0.0666
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0294 0.0419
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0329 0.2013
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0033 0.0467 0.0666
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0294 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0294 0.0464
Schistosoma mansoni pol-related 0.0033 0.0467 0.0666
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.134 0.1909
Onchocerca volvulus 0.0072 0.134 0.3093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0114 0.0162
Echinococcus granulosus GPCR family 2 0.0016 0.0084 0.012
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0236 0.0337
Mycobacterium leprae Probable lipase LipE 0.0072 0.134 1
Brugia malayi beta-lactamase family protein 0.0072 0.134 0.2295
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0033 0.0467 0.0666
Brugia malayi nuclear receptor NHR-88 0.0025 0.0294 0.0464
Loa Loa (eye worm) hypothetical protein 0.0071 0.1313 0.1837
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0574 0.0954
Entamoeba histolytica hypothetical protein 0.022 0.4658 1
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3673 0.6247
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0286 0.0093
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0535 0.0763

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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