Detailed information for compound 172574

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 332.503 | Formula: C19H28N2OS
  • H donors: 0 H acceptors: 1 LogP: 3.82 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N([C@@H]1CCCC[C@@H]1N1CCCC1)C)CSc1ccccc1
  • InChi: 1S/C19H28N2OS/c1-20(19(22)15-23-16-9-3-2-4-10-16)17-11-5-6-12-18(17)21-13-7-8-14-21/h2-4,9-10,17-18H,5-8,11-15H2,1H3/t17?,18-/m0/s1
  • InChiKey: GOROEWQCTXXDJM-ZVAWYAOSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major GTP-binding protein, putative 0.0022 0.0091 0.0137
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0574 0.056
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.003 0.003
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0066 0.0066
Echinococcus multilocularis geminin 0.0175 0.1699 0.1699
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0558 0.0544
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.4535 0.4526
Brugia malayi jmjC domain containing protein 0.0017 0.003 0.0014
Schistosoma mansoni heat shock protein 0.0031 0.0186 0.0172
Leishmania major hypothetical protein, conserved 0.0017 0.0039 0.002
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0047 0.0047
Leishmania major hypothetical protein, conserved 0.0017 0.0039 0.002
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0323 0.0322
Echinococcus multilocularis snurportin 1 0.0326 0.3281 0.3281
Loa Loa (eye worm) RING finger protein 20 0.0017 0.0039 0.0039
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0049 0.0033
Brugia malayi MH2 domain containing protein 0.0018 0.0047 0.0031
Brugia malayi jmjC domain containing protein 0.0017 0.003 0.0014
Brugia malayi hypothetical protein 0.0017 0.0039 0.0023
Schistosoma mansoni ran 0.0022 0.0091 0.0077
Onchocerca volvulus 0.0343 0.3464 0.3438
Echinococcus granulosus snurportin 1 0.0326 0.3281 0.3281
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Echinococcus multilocularis smad 0.0018 0.0047 0.0047
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Brugia malayi MH1 domain containing protein 0.0018 0.0047 0.0031
Toxoplasma gondii ran binding protein 0.0343 0.3464 0.3444
Echinococcus granulosus GPCR family 2 0.0018 0.0049 0.0049
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Echinococcus multilocularis 0.0017 0.0039 0.0039
Echinococcus multilocularis cpg binding protein 0.0065 0.0535 0.0535
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0574 0.3588
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0018 0.004 0.0039
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0049 0.0049
Trichomonas vaginalis ankyrin, putative 0.0017 0.0039 0.0038
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0115 0.0115
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0064 0.0076
Trypanosoma cruzi heat shock protein 85, putative 0.0041 0.0282 0.0559
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0047 0.0047
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Schistosoma mansoni hypothetical protein 0.0964 1 1
Onchocerca volvulus 0.0343 0.3464 0.3438
Echinococcus granulosus endoplasmin 0.0044 0.0323 0.0323
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0018 0.0049 0.0034
Echinococcus granulosus lamin dm0 0.0029 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0574 0.2051
Brugia malayi Zinc finger protein 183 homolog 0.0018 0.004 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0343 0.3464 0.7623
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Echinococcus multilocularis lamin 0.0029 0.0155 0.0155
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Echinococcus multilocularis lamin dm0 0.0029 0.0155 0.0155
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0017 0.0039 0.0039
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0155 0.014
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0115 0.019
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0323 0.0322
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Echinococcus granulosus smad 0.0018 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0175 0.1692 0.1692
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3314 0.3314
Schistosoma mansoni hypothetical protein 0.0343 0.3464 0.3454
Echinococcus multilocularis heat shock protein 90 0.0047 0.0354 0.0354
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0017 0.0039 0.0038
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0017 0.0039 0.0038
Schistosoma mansoni protein phosphatase 2C 0.0017 0.003 0.0015
Echinococcus granulosus heat shock protein 90 0.0047 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0049
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.4535 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0161 0.1545 1
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0343 0.3464 0.3464
Schistosoma mansoni endoplasmin 0.0047 0.0354 0.0339
Brugia malayi Neuralized family protein 0.0017 0.0039 0.0023
Schistosoma mansoni jumonji domain containing protein 0.0017 0.003 0.0015
Schistosoma mansoni smad 0.0018 0.0047 0.0032
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0329 0.3314 1
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0017 0.0039 0.0023
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0047 0.0047
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0574 0.2051
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0546 0.0532
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0017 0.0039 0.0038
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0468 0.0468
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0558 0.0544
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Echinococcus multilocularis zinc finger protein Ran binding 0.0343 0.3464 0.3464
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0343 0.3464 0.3444
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.003 0.003
Schistosoma mansoni ring finger protein 151 0.0017 0.0039 0.0024
Echinococcus multilocularis dnaJ subfamily B 0.0437 0.4457 0.4457
Echinococcus granulosus microtubule associated protein 2 0.0738 0.7619 0.7619
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0354 0.0719
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3314 0.3314
Trypanosoma cruzi hypothetical protein 0.0017 0.0039 0.002
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0039 0.002
Schistosoma mansoni smad1 5 8 and 0.0018 0.0047 0.0032
Leishmania major hypothetical protein, conserved 0.0017 0.0039 0.002
Toxoplasma gondii hypothetical protein 0.0017 0.0039 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.003 0.003
Plasmodium vivax endoplasmin, putative 0.0047 0.0354 0.0325
Schistosoma mansoni mind bomb 0.0017 0.0039 0.0024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0115 0.0115
Schistosoma mansoni rnf5 0.0017 0.0039 0.0024
Brugia malayi jmjC domain containing protein 0.0066 0.0546 0.0531
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0115 0.0115
Schistosoma mansoni brg-1 associated factor 0.0964 1 1
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0343 0.3464 0.3464
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.0017 0.0039 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3314 0.3314
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0176 0.0147
Trypanosoma cruzi heat shock protein, putative 0.0031 0.0186 0.0348
Echinococcus granulosus importin subunit beta 1 0.003 0.0176 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Echinococcus multilocularis muscleblind protein 1 0.0175 0.1692 0.1692
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0546 0.0546
Trypanosoma brucei heat shock protein, putative 0.0047 0.0354 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0017 0.0039 0.0039
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0017 0.0039 0.0024
Giardia lamblia Heat shock protein HSP 90-alpha 0.0041 0.0282 0.0742
Loa Loa (eye worm) heat shock protein 75 0.0031 0.0186 0.0186
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0051 0.0036
Trichomonas vaginalis ran, putative 0.0022 0.0091 0.0091
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.003 0.003
Echinococcus multilocularis endoplasmin 0.0044 0.0323 0.0323
Echinococcus granulosus zinc finger protein Ran binding 0.0343 0.3464 0.3464
Loa Loa (eye worm) hypothetical protein 0.0343 0.3464 0.3464
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0044 0.0323 0.5
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Trypanosoma cruzi Heat shock protein 83, putative 0.0047 0.0354 0.0719
Brugia malayi hypothetical protein 0.0017 0.0039 0.0023
Echinococcus multilocularis ring and YY1 binding protein 0.0343 0.3464 0.3464
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0343 0.3464 0.3453
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Brugia malayi MH2 domain containing protein 0.0018 0.0047 0.0031
Trichomonas vaginalis endoplasmin, putative 0.0034 0.0217 0.0216
Schistosoma mansoni microtubule-associated protein tau 0.0738 0.7619 0.7616
Schistosoma mansoni Smad4 0.0018 0.0047 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Leishmania major hypothetical protein, conserved 0.0017 0.0039 0.002
Plasmodium vivax hypothetical protein, conserved 0.0964 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Schistosoma mansoni peter pan-related 0.0017 0.0039 0.0024
Trypanosoma brucei predicted zinc finger protein 0.0017 0.0039 0.002
Plasmodium vivax importin-beta 2, putative 0.003 0.0176 0.0147
Entamoeba histolytica Ran family GTPase 0.0022 0.0091 0.016
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Loa Loa (eye worm) hypothetical protein 0.0028 0.015 0.015
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0017 0.0039 0.0038
Trypanosoma brucei heat shock protein, putative 0.0047 0.0354 0.0719
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0017 0.0039 0.0009
Leishmania major hypothetical protein, conserved 0.0017 0.0039 0.002
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0574 0.0574
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.4535 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.037 0.037
Echinococcus granulosus heat shock protein 90 0.0041 0.0282 0.0282
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Loa Loa (eye worm) transcription factor SMAD2 0.0267 0.2666 0.2666
Trypanosoma brucei heat shock protein, putative 0.0047 0.0354 0.0719
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0017 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0018 0.0049 0.0034
Leishmania major heat shock protein, putative 0.0031 0.0186 0.0348
Schistosoma mansoni hypothetical protein 0.0018 0.0049 0.0034
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0468 0.0453
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0558 0.0544
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0017 0.0039 0.0039
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0041 0.0282 0.0282
Echinococcus granulosus Smad4 0.0018 0.0047 0.0047
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0017 0.0039 0.0038
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.003 0.0001
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0343 0.3464 0.7623
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.0017 0.0039 0.0009
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Echinococcus multilocularis muscleblind protein 0.0175 0.1692 0.1692
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0343 0.3464 0.3453
Leishmania major hypothetical protein, conserved 0.0017 0.0039 0.002
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0016 0.0016
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0947 0.9826 0.9826
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0964 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0091 0.0091
Toxoplasma gondii RING zinc finger protein 0.0017 0.0039 0.0009
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.0546 0.0546
Echinococcus multilocularis musashi 0.0029 0.0155 0.0155
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0031 0.0186 0.0186
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0574 0.2051
Schistosoma mansoni hypothetical protein 0.0018 0.004 0.0025
Schistosoma mansoni cpg binding protein 0.0065 0.0535 0.052
Loa Loa (eye worm) hypothetical protein 0.0343 0.3464 0.3464
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0017 0.0039 0.0039
Brugia malayi Muscleblind-like protein 0.0175 0.1692 0.1679
Echinococcus multilocularis ring finger protein 170 0.0017 0.0039 0.0039
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0546 0.0532
Echinococcus granulosus cell growth regulator with ring finger domain 0.0017 0.0039 0.0039
Echinococcus multilocularis GPCR, family 2 0.0018 0.0049 0.0049
Echinococcus multilocularis heat shock protein 0.0047 0.0354 0.0354
Trypanosoma brucei heat shock protein, putative 0.0047 0.0354 0.0719
Trypanosoma brucei heat shock protein, putative 0.0047 0.0354 0.0719
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0091 0.0091
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.051 0.051
Leishmania major hypothetical protein, conserved 0.0343 0.3464 0.7623
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0343 0.3464 0.3453
Schistosoma mansoni zinc finger protein 0.0017 0.0039 0.0024
Chlamydia trachomatis DNA topoisomerase I 0.0964 1 0.5
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.003 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0039 0.002
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0017 0.0039 0.002
Schistosoma mansoni hypothetical protein 0.0017 0.0039 0.0024
Schistosoma mansoni cpg binding protein 0.0061 0.0498 0.0484
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0964 1 1
Schistosoma mansoni hypothetical protein 0.0964 1 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.003 0.0016
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.003 0.003
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.003 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0343 0.3464 0.3464
Echinococcus granulosus muscleblind protein 0.0175 0.1692 0.1692
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0017 0.0039 0.0009
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Brugia malayi Isocitrate dehydrogenase 0.0017 0.003 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Leishmania major hypothetical protein, conserved 0.0343 0.3464 0.7623
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Schistosoma mansoni hypothetical protein 0.0437 0.4457 0.4449
Leishmania major hypothetical protein, conserved 0.0343 0.3464 0.7623
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Onchocerca volvulus 0.0061 0.0498 0.0461
Loa Loa (eye worm) endoplasmin 0.0047 0.0354 0.0354
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0047 0.0032
Echinococcus multilocularis SWI:SNF matrix associated 0.0964 1 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0049 0.0033
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0574 0.1208
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0054 0.0054
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0964 1 1
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0161 0.1545 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.1219 0.1205
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0964 1 1
Echinococcus granulosus geminin 0.0175 0.1699 0.1699
Plasmodium vivax heat shock protein, putative 0.018 0.1745 0.172
Giardia lamblia Fructose-bisphosphate aldolase 0.0329 0.3314 1
Plasmodium vivax zinc finger protein, putative 0.0017 0.0039 0.0009
Schistosoma mansoni hypothetical protein 0.004 0.0274 0.026
Toxoplasma gondii heat shock protein 90, putative 0.0047 0.0354 0.0325
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.003 0.0001
Schistosoma mansoni intermediate filament proteins 0.0029 0.0155 0.0141
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0017 0.0039 0.002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0175 0.1692 0.1692
Echinococcus granulosus lamin 0.0029 0.0155 0.0155
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.003 0.003
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Schistosoma mansoni lamin 0.0029 0.0155 0.0141
Schistosoma mansoni heat shock protein 0.0047 0.0354 0.0339
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0091 0.0137
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0343 0.3464 0.7623
Schistosoma mansoni hypothetical protein 0.0175 0.1699 0.1687
Schistosoma mansoni phd/f-box containing protein 0.0017 0.003 0.0015
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Schistosoma mansoni hypothetical protein 0.0326 0.3281 0.3271
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0091 0.0137
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0039 0.0024
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0343 0.3464 0.3453
Brugia malayi hypothetical protein 0.0017 0.0039 0.0023
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Trichomonas vaginalis hypothetical protein 0.0017 0.0039 0.0038
Brugia malayi brahma associated protein 60 kDa 0.0964 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.037 0.0356
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.003 0.003
Plasmodium vivax RING zinc finger protein, putative 0.0017 0.0039 0.0009
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0066 0.0066
Echinococcus granulosus heat shock protein 0.0047 0.0354 0.0354
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0029 0.0155 0.0155
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0161 0.1545 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Schistosoma mansoni zinc finger protein 0.0343 0.3464 0.3454
Echinococcus multilocularis SWI:SNF matrix associated 0.0964 1 1
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0017 0.0039 0.0039
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0343 0.3464 0.7623
Echinococcus granulosus ring and YY1 binding protein 0.0343 0.3464 0.3464
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0343 0.3464 0.3464
Leishmania major hypothetical protein, conserved 0.0017 0.0039 0.002
Toxoplasma gondii heat shock protein 75, putative 0.0031 0.0186 0.0157
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.003 0.003
Brugia malayi heat shock protein 90 0.0047 0.0354 0.0338
Trypanosoma cruzi WLM domain containing protein, putative 0.0343 0.3464 0.7623
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0091 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0049 0.0049
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0343 0.3464 0.3444
Trypanosoma cruzi WLM domain containing protein, putative 0.0343 0.3464 0.7623
Echinococcus granulosus intermediate filament protein 0.0029 0.0155 0.0155
Schistosoma mansoni RNA binding protein 0.0343 0.3464 0.3454
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0017 0.0039 0.0039
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0015 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0558 0.0544
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Brugia malayi B-box zinc finger family protein 0.0017 0.0039 0.0023
Plasmodium vivax heat shock protein 86, putative 0.0047 0.0354 0.0325
Echinococcus multilocularis heat shock protein 90 0.0041 0.0282 0.0282
Onchocerca volvulus 0.0964 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0049 0.0049
Onchocerca volvulus 0.0029 0.0155 0.0117
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0039 0.002
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0964 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0574 0.056
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Toxoplasma gondii hypothetical protein 0.0017 0.0039 0.0009
Brugia malayi RNA, U transporter 1 0.0087 0.0768 0.0753
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0015 0.0015
Schistosoma mansoni ran 0.0022 0.0091 0.0077
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0558 0.0543
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0274 0.0259
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0017 0.0039 0.0038
Echinococcus granulosus tar DNA binding protein 0.0067 0.0558 0.0558
Plasmodium vivax DNA repair protein RAD5, putative 0.0017 0.0039 0.0009
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0964 1 1
Plasmodium falciparum RING zinc finger protein, putative 0.0017 0.0039 0.0009
Echinococcus multilocularis SWI:SNF matrix associated 0.0964 1 1
Echinococcus granulosus cpg binding protein 0.0065 0.0535 0.0535
Brugia malayi Hsp90 protein 0.0031 0.0186 0.0171
Trypanosoma brucei hypothetical protein, conserved 0.0343 0.3464 0.7623
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0558 0.0558
Schistosoma mansoni smad1 5 8 and 0.0018 0.0047 0.0032
Schistosoma mansoni cpg binding protein 0.0065 0.0535 0.052
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0044 0.0323 0.0651
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0091 0.0062
Brugia malayi Smad1 0.0018 0.0047 0.0031
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.0017 0.0039 0.0009
Brugia malayi hypothetical protein 0.0017 0.0039 0.0023
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0017 0.0039 0.0039
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.0017 0.0039 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0017 0.0039 0.0038
Leishmania major hypothetical protein, conserved 0.0343 0.3464 0.7623
Loa Loa (eye worm) heat shock protein 90 0.0047 0.0354 0.0354
Schistosoma mansoni hypothetical protein 0.0175 0.1699 0.1687
Echinococcus multilocularis importin subunit beta 1 0.003 0.0176 0.0176
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0558 0.0558
Loa Loa (eye worm) MH2 domain-containing protein 0.0267 0.2666 0.2666
Schistosoma mansoni hypothetical protein 0.0018 0.0049 0.0034
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0017 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0227 0.2247 0.2247
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0039 0.002
Plasmodium falciparum importin beta, putative 0.003 0.0176 0.0147
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3314 0.3314
Brugia malayi Importin beta-1 subunit 0.003 0.0176 0.016
Trypanosoma cruzi heat shock protein 90, putative 0.0047 0.0354 0.0719
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.003 0.003
Leishmania major hypothetical protein, conserved 0.0017 0.0039 0.002
Schistosoma mansoni peter pan-related 0.0017 0.0039 0.0024
Schistosoma mansoni endoplasmin 0.0047 0.0354 0.0339
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0282 0.0281
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.003
Trichomonas vaginalis heat shock protein, putative 0.0047 0.0354 0.0353
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Brugia malayi RING finger protein 20 0.0017 0.0039 0.0023
Plasmodium falciparum heat shock protein 90, putative 0.0028 0.0145 0.0116
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.003
Echinococcus granulosus phd:f box containing protein 0.0017 0.003 0.003
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0329 0.3314 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0054 0.0054
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0964 1 1
Brugia malayi MH2 domain containing protein 0.0267 0.2666 0.2655
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.037 0.037
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Trypanosoma brucei hypothetical protein, conserved 0.0343 0.3464 0.7623
Schistosoma mansoni smad1 5 8 and 0.0018 0.0047 0.0032
Loa Loa (eye worm) hypothetical protein 0.004 0.0274 0.0274
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0039 0.002
Echinococcus granulosus ring finger protein 113a 0.0018 0.004 0.004
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0574 0.0546
Plasmodium vivax trophozoite exported protein 1, putative 0.0017 0.0039 0.0009
Brugia malayi Endoplasmin precursor 0.0047 0.0354 0.0338
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0091 0.0062
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Loa Loa (eye worm) hypothetical protein 0.0445 0.4535 0.4535
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0031 0.0186 0.0148
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.003 0.0001
Plasmodium falciparum heat shock protein 90, putative 0.018 0.1745 0.172
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.4535 1
Leishmania major hypothetical protein, conserved 0.0017 0.0039 0.002
Trypanosoma cruzi hypothetical protein 0.0017 0.0039 0.002
Echinococcus granulosus Zinc finger RanBP2 type 0.0343 0.3464 0.3464
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Giardia lamblia Heat shock protein HSP 90-alpha 0.0047 0.0354 0.0962
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.1073 0.1046
Plasmodium vivax heat shock protein 90, putative 0.0031 0.0186 0.0157
Brugia malayi intermediate filament protein 0.0029 0.0155 0.014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.003 0.003
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0343 0.3464 0.7623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0044 0.0323 0.1933
Plasmodium falciparum zinc finger protein, putative 0.0017 0.0039 0.0009
Brugia malayi RNA binding protein 0.0067 0.0558 0.0543
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Leishmania major hypothetical protein, conserved 0.0017 0.0039 0.002
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0343 0.3464 0.7623
Echinococcus granulosus RING finger protein 185 0.0017 0.0039 0.0039
Brugia malayi SWIB/MDM2 domain containing protein 0.0964 1 1
Echinococcus granulosus SWI:SNF matrix associated 0.0964 1 1
Trichomonas vaginalis ion channel nompc, putative 0.0017 0.0039 0.0038
Brugia malayi hypothetical protein 0.0017 0.0039 0.0023
Leishmania major hypothetical protein, conserved 0.0343 0.3464 0.7623
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.003 0.003
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0091 0.0091
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0049 0.0049
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.003 0.003
Treponema pallidum fructose-bisphosphate aldolase 0.0329 0.3314 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.003 0.003
Brugia malayi hypothetical protein 0.0017 0.0039 0.0023
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0354 0.0962
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.037 0.0356
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0017 0.0039 0.002
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0964 1 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0039 0.002
Plasmodium falciparum trophozoite exported protein 1 0.0017 0.0039 0.0009
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0017 0.0039 0.0039
Onchocerca volvulus 0.0029 0.0155 0.0117
Plasmodium falciparum E3 ubiquitin-protein ligase, putative 0.0017 0.0039 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0343 0.3464 0.7623
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0017 0.0039 0.0038
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0015 0.0015
Leishmania major hypothetical protein, conserved 0.0017 0.0039 0.002
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0558 0.0558
Trypanosoma brucei heat shock protein, putative 0.0047 0.0354 0.0719
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0145 0.0144
Echinococcus granulosus dnaJ subfamily B 0.0437 0.4457 0.4457
Loa Loa (eye worm) RiNg Finger protein family member 0.0018 0.004 0.004
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.003 0.003
Toxoplasma gondii Hsp90 domain-containing protein 0.018 0.1745 0.172
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Chlamydia trachomatis SWIB complex protein 0.0964 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.0468 0.0468
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.037 0.0354
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0343 0.3464 0.7623
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Trypanosoma brucei DNA repair protein, putative 0.0017 0.0039 0.002
Brugia malayi CXXC zinc finger family protein 0.0061 0.0498 0.0483
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0031 0.0186 0.0186
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0343 0.3464 0.7623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3314 0.3314
Schistosoma mansoni hypothetical protein 0.0017 0.0039 0.0024
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0017 0.0039 0.0038
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.003 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3314 0.3314
Brugia malayi YY1-associated factor 2 0.0343 0.3464 0.3453
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.003
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.051 0.051
Schistosoma mansoni heat shock protein 0.0047 0.0354 0.0339
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Leishmania major hypothetical protein, conserved 0.0017 0.0039 0.002
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0343 0.3464 0.3438
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.037 0.0356
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0964 1 1
Plasmodium falciparum E3 ubiquitin-protein ligase RNF5, putative 0.0017 0.0039 0.0009
Brugia malayi jmjC domain containing protein 0.0017 0.003 0.0014
Brugia malayi jmjC domain containing protein 0.0062 0.051 0.0495
Schistosoma mansoni lamin 0.0029 0.0155 0.0141
Loa Loa (eye worm) Smad1 0.0018 0.0047 0.0047
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Brugia malayi jmjC domain containing protein 0.0017 0.003 0.0014
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0964 1 1
Trypanosoma brucei heat shock protein, putative 0.0047 0.0354 0.0719
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0176 0.0325
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0091 0.0062
Trypanosoma brucei heat shock protein, putative 0.0047 0.0354 0.0719
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0054 0.0054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3314 0.3314
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0354 0.0719
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.037 0.037
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.003 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0039 0.002
Echinococcus multilocularis phd:f box containing protein 0.0017 0.003 0.003
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.003 0.0001
Trypanosoma cruzi heat shock protein 90, putative 0.0041 0.0282 0.0559
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0155 0.0155
Toxoplasma gondii hypothetical protein 0.0017 0.0039 0.0009
Toxoplasma gondii hypothetical protein 0.0017 0.0039 0.0009
Trypanosoma brucei heat shock protein 90, putative 0.0047 0.0354 0.0719
Toxoplasma gondii heat shock protein HSP90 0.0047 0.0354 0.0325
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Schistosoma mansoni TRABID protein (C64 family) 0.0343 0.3464 0.3454
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0217 0.0216
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Brugia malayi TAR-binding protein 0.0067 0.0558 0.0543
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.051 0.051
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Entamoeba histolytica heat shock protein 90, putative 0.0047 0.0354 0.0962
Echinococcus multilocularis Smad4 0.0018 0.0047 0.0047
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0091 0.0076
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0039
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0017 0.0039 0.0039
Trichomonas vaginalis ankyrin, putative 0.0017 0.0039 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Leishmania major DNA repair protein-like protein 0.0017 0.0039 0.002
Trypanosoma brucei Heat shock protein 83, putative 0.0047 0.0354 0.0719
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Echinococcus multilocularis ring finger protein 113a 0.0018 0.004 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.037 0.037
Onchocerca volvulus 0.0343 0.3464 0.3438
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0326 0.3281 0.3281
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0176 0.0325
Brugia malayi RING zinc finger protein 0.0017 0.0039 0.0023
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0354 0.0719
Loa Loa (eye worm) RNA binding protein 0.0067 0.0558 0.0558
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0558 0.0544
Trypanosoma brucei heat shock protein 84, putative 0.0031 0.0186 0.0348
Onchocerca volvulus 0.0343 0.3464 0.3438
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0015 0.0015
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0091 0.0137
Toxoplasma gondii helicase, putative 0.0017 0.0039 0.0009
Schistosoma mansoni importin beta-1 0.003 0.0176 0.0161
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Echinococcus multilocularis microtubule associated protein 2 0.0738 0.7619 0.7619
Brugia malayi MH1 domain containing protein 0.0018 0.0047 0.0031
Leishmania major hypothetical protein, conserved 0.0017 0.0039 0.002
Brugia malayi Zinc finger, C2H2 type family protein 0.0017 0.0039 0.0023
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.003 0.0176 0.0176
Schistosoma mansoni jumonji domain containing protein 0.0062 0.051 0.0496
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0031 0.0186 0.0451
Trypanosoma brucei ring finger containing protein 0.0017 0.0039 0.002
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0017 0.0039 0.002
Leishmania major importin beta-1 subunit, putative 0.0025 0.0115 0.019
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0155 0.0155
Echinococcus multilocularis RING finger protein 185 0.0017 0.0039 0.0039
Plasmodium falciparum endoplasmin, putative 0.0034 0.0217 0.0188
Plasmodium falciparum heat shock protein 90 0.0047 0.0354 0.0325
Trypanosoma cruzi heat shock protein 85, putative 0.0047 0.0354 0.0719
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.037 0.037
Trichomonas vaginalis ankyrin, putative 0.0017 0.0039 0.0038
Echinococcus granulosus ring finger protein 170 0.0017 0.0039 0.0039
Leishmania major hypothetical protein 0.0017 0.0039 0.002
Loa Loa (eye worm) hypothetical protein 0.0343 0.3464 0.3464
Loa Loa (eye worm) hypothetical protein 0.0343 0.3464 0.3464
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0498 0.0498
Leishmania major hypothetical protein, unknown function 0.0017 0.0039 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0343 0.3464 0.7623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0329 0.3314 0.3314
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0468 0.0453
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0017 0.0039 0.002
Brugia malayi isocitrate dehydrogenase 0.0017 0.003 0.0014
Giardia lamblia Grp94/Hsp90 0.0044 0.0323 0.0868
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.003 0.0001
Schistosoma mansoni fusion 0.0343 0.3464 0.3454
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.003 0.0001
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0574 0.0574
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0039 0.0038
Loa Loa (eye worm) brahma associated protein 0.0964 1 1
Leishmania major heat shock protein 83-1 0.0047 0.0354 0.0719
Entamoeba histolytica hypothetical protein 0.0025 0.0115 0.0234

Activities

Activity type Activity value Assay description Source Reference
Control (binding) = 58.41 % Binding affinity against opioid receptor kappa 1 using [3H]U-69,593 as a radioligand ChEMBL. 2172538
Control (binding) = 88.98 % Binding affinity against opioid receptor kappa 1 using with [3H]-bremazocine as radioligand ChEMBL. 2172538
IC50 (binding) = 200 nM Binding affinity for sigma opioid receptor using [3H]-(+)-3-PPP as radioligand ChEMBL. 2172538

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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