Detailed information for compound 1728182

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 922.036 | Formula: C48H59N9O10
  • H donors: 11 H acceptors: 10 LogP: 1.51 Rotable bonds: 32
    Rule of 5 violations (Lipinski): 3
  • SMILES: O=C(N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)NCCC(=O)N[C@H](C(=O)N)Cc1ccccc1)C)Cc1ccc(cc1)O)Cc1ccccc1)CCNC(=O)[C@H](NC(=O)[C@H](Cc1ccc(cc1)O)N)C
  • InChi: 1S/C48H59N9O10/c1-29(53-46(65)37(49)25-33-13-17-35(58)18-14-33)44(63)51-24-22-42(61)56-39(27-32-11-7-4-8-12-32)48(67)57-40(28-34-15-19-36(59)20-16-34)47(66)54-30(2)45(64)52-23-21-41(60)55-38(43(50)62)26-31-9-5-3-6-10-31/h3-20,29-30,37-40,58-59H,21-28,49H2,1-2H3,(H2,50,62)(H,51,63)(H,52,64)(H,53,65)(H,54,66)(H,55,60)(H,56,61)(H,57,67)/t29-,30-,37+,38+,39+,40+/m1/s1
  • InChiKey: VJTRLNGWCWXROJ-KPPTUHEKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Mu opioid receptor Starlite/ChEMBL References
Rattus norvegicus Delta opioid receptor Starlite/ChEMBL References
Mus musculus opioid receptor, delta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Delta opioid receptor   372 aa 353 aa 21.0 %
Onchocerca volvulus Delta opioid receptor   372 aa 344 aa 22.1 %
Brugia malayi ORL1-like opioid receptor Delta opioid receptor   372 aa 300 aa 24.7 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.2 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Mu opioid receptor   398 aa 397 aa 22.7 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Delta opioid receptor   372 aa 315 aa 28.6 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   398 aa 335 aa 20.6 %
Schistosoma japonicum Rhodopsin, putative Mu opioid receptor   398 aa 328 aa 23.2 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Delta opioid receptor   372 aa 366 aa 22.7 %
Onchocerca volvulus Delta opioid receptor   372 aa 316 aa 26.9 %
Brugia malayi GnHR receptor homolog Delta opioid receptor   372 aa 313 aa 18.5 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Mu opioid receptor   398 aa 334 aa 23.1 %
Onchocerca volvulus Programmed cell death protein 5 homolog Mu opioid receptor   398 aa 323 aa 24.1 %
Onchocerca volvulus Delta opioid receptor   372 aa 386 aa 22.8 %
Schistosoma mansoni peptide (allatostatin)-like receptor Delta opioid receptor   372 aa 353 aa 29.2 %
Loa Loa (eye worm) neuropeptide F receptor Delta opioid receptor   372 aa 317 aa 23.3 %
Onchocerca volvulus Delta opioid receptor   372 aa 349 aa 22.1 %
Echinococcus multilocularis allatostatin A receptor Delta opioid receptor   372 aa 302 aa 28.5 %
Echinococcus granulosus allatostatin A receptor Delta opioid receptor   372 aa 302 aa 27.8 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Delta opioid receptor   372 aa 320 aa 25.6 %
Echinococcus granulosus thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0354 0.0448
Echinococcus multilocularis mitogen activated protein kinase 14 0.013 0.0978 0.0978
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0102
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0011 0.0032 0.0032
Echinococcus multilocularis vesicular acetylcholine transporter 0.0468 0.3674 0.3674
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0032 0.0032
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis tyrosine protein kinase pr2 0.0018 0.0081 0.0081
Brugia malayi Dopamine receptor 0.0011 0.0032 0.004
Echinococcus granulosus retinal guanylyl cyclase 2 0.0018 0.0081 0.0081
Brugia malayi Tyrosine-protein kinase PR2 0.0018 0.0081 0.0102
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0032 0.004
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0018 0.0081 0.0081
Loa Loa (eye worm) RGC/RGC protein kinase 0.0018 0.0081 0.0102
Trypanosoma brucei Sterol methyltransferase, putative 0.0196 0.15 1
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0018 0.0081 0.0102
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0018 0.0081 0.0081
Brugia malayi vesicular acetylcholine transporter unc-17 0.0468 0.3674 0.4651
Echinococcus granulosus vesicular acetylcholine transporter 0.0468 0.3674 0.3674
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0011 0.0032 0.0087
Schistosoma mansoni protein kinase 0.0018 0.0081 0.0102
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0018 0.0081 0.0081
Brugia malayi G-protein coupled receptor 0.0011 0.0032 0.004
Echinococcus multilocularis ephrin type A receptor 4 A 0.0018 0.0081 0.0081
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0071 0.009
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0011 0.0032 0.004
Echinococcus granulosus survival motor neuron protein 1 0.024 0.1858 0.1858
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0018 0.0081 0.0081
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0018 0.0081 0.0506
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Schistosoma mansoni amine GPCR 0.0011 0.0032 0.004
Brugia malayi Furin-like cysteine rich region family protein 0.0018 0.0081 0.0102
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0134 0.0311
Echinococcus granulosus activated cdc42 kinase 1 0.0018 0.0081 0.0081
Loa Loa (eye worm) TK/DDR protein kinase 0.0018 0.0081 0.0102
Giardia lamblia Protein 21.1 0.0018 0.0081 0.0000027643
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0018 0.0081 0.0081
Brugia malayi G protein-coupled receptor F59B2.13 0.0011 0.0032 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Brugia malayi Importin beta-1 subunit 0.003 0.0179 0.0227
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0018 0.0081 0.0081
Toxoplasma gondii exonuclease III APE 0.0019 0.0088 0.074
Loa Loa (eye worm) TK protein kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis tyrosine protein kinase csk 0.0018 0.0081 0.0081
Schistosoma mansoni neuropeptide f receptor 76f 0.0011 0.0032 0.004
Brugia malayi hypothetical protein 0.0011 0.0032 0.004
Echinococcus granulosus tyrosine protein kinase csk 0.0018 0.0081 0.0081
Trypanosoma brucei Pseudokinase, putative 0.0018 0.0081 0.0506
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0081 0.0102
Schistosoma mansoni protein kinase 0.0018 0.0081 0.0102
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0011 0.0032 0.004
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) melatonin receptor type 1A 0.0011 0.0032 0.004
Loa Loa (eye worm) TK/CSK protein kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.002 0.01 0.0637
Trichomonas vaginalis TKL family protein kinase 0.0018 0.0081 0.000000057095
Echinococcus multilocularis tyrosine protein kinase shark 0.0018 0.0081 0.0081
Brugia malayi AKH receptor 0.0011 0.0032 0.004
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0018 0.0081 0.0102
Echinococcus multilocularis FL cytokine receptor 0.0018 0.0081 0.0081
Echinococcus granulosus epidermal growth factor receptor 0.0018 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0018 0.0081 0.0081
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Echinococcus multilocularis tyrosine protein kinase HCK 0.0018 0.0081 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0032 0.004
Plasmodium vivax importin-beta 2, putative 0.003 0.0179 1
Brugia malayi putative neuropeptide receptor NPR1 0.0011 0.0032 0.004
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0998 0.7899 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0011 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Brugia malayi Guanylyl cyclase protein 23 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0102
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0011 0.0032 0.004
Schistosoma mansoni protein kinase 0.0018 0.0081 0.0102
Schistosoma mansoni growth hormone secretagogue receptor 0.0011 0.0032 0.004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0032 0.0032
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0032 0.0032
Onchocerca volvulus 0.0011 0.0032 0.0087
Echinococcus multilocularis sex peptide receptor 0.0011 0.0032 0.0032
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0175 0.0221
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0196 0.15 1
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.009
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0032 0.004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0081 0.0102
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0468 0.3674 1
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0032 0.0032
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Echinococcus granulosus tyrosine protein kinase pr2 0.0018 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.009
Brugia malayi Serotonin receptor 0.0011 0.0032 0.004
Echinococcus granulosus raf serine:threonine protein kinase 0.0018 0.0081 0.0081
Onchocerca volvulus 0.0011 0.0032 0.0087
Entamoeba histolytica protein kinase domain containing protein 0.002 0.01 0.1382
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Brugia malayi Tachykinin-like peptides receptor 99D 0.0011 0.0032 0.004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0354 0.0448
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0196 0.15 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0011 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase 0.0018 0.0081 0.0081
Echinococcus granulosus tyrosine protein kinase shark 0.0018 0.0081 0.0081
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0018 0.0081 0.0102
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Echinococcus granulosus tyrosine protein kinase csk 0.0018 0.0081 0.0081
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0134 0.0311
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0088 0.5
Echinococcus granulosus tyrosine protein kinase Src64B 0.0018 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0018 0.0081 0.0081
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.009
Onchocerca volvulus 0.0029 0.0175 0.0476
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Leishmania major protein kinase, putative 0.002 0.01 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0102
Schistosoma mansoni alpha-1 adrenergic receptor 0.0011 0.0032 0.004
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0116 0.0116
Echinococcus multilocularis integrin linked protein kinase 0.0018 0.0081 0.0081
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Schistosoma mansoni neuropeptide receptor 0.0011 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Echinococcus multilocularis neuropeptide s receptor 0.0011 0.0032 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis neuropeptide receptor 0.0011 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Schistosoma mansoni hypothetical protein 0.0035 0.0223 0.0282
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Leishmania major sterol 24-c-methyltransferase, putative 0.0196 0.15 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0331 0.0419
Giardia lamblia Kinase, NEK 0.0018 0.0081 0.0000027643
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0088 0.0042
Schistosoma mansoni amine GPCR 0.0011 0.0032 0.004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0032 0.0032
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0011 0.0032 0.004
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0032 0.0032
Echinococcus granulosus 7TM GPCR rhodopsin 0.0011 0.0032 0.0032
Entamoeba histolytica Ran family GTPase 0.0022 0.0116 0.2499
Echinococcus granulosus GPCR family 2 0.0016 0.0071 0.0071
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0018 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0349 0.272 0.3443
Echinococcus granulosus peptide allatostatin:somatostatin 0.0011 0.0032 0.0032
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0011 0.0032 0.0032
Trypanosoma brucei Flagellum attachment zone protein 20 0.0018 0.0081 0.0506
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0032 0.004
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0018 0.0081 0.0081
Onchocerca volvulus 0.0011 0.0032 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0032 0.0032
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0468 0.3674 0.4651
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0088 0.0051
Onchocerca volvulus 0.0018 0.0081 0.022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0223 0.0223
Echinococcus multilocularis tyrosine protein kinase Blk 0.0018 0.0081 0.0081
Entamoeba histolytica ankyrin repeat protein 0.0018 0.0081 0.00000069082
Echinococcus granulosus g-protein coupled receptor 0.0011 0.0032 0.0032
Onchocerca volvulus 0.0011 0.0032 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0018 0.0081 0.0081
Echinococcus multilocularis raf serine:threonine protein kinase 0.0018 0.0081 0.0081
Schistosoma mansoni opsin-like receptor 0.0011 0.0032 0.004
Echinococcus granulosus retinal guanylyl cyclase 2 0.0018 0.0081 0.0081
Leishmania major sterol 24-c-methyltransferase, putative 0.0196 0.15 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0088 0.2055
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0032 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0032 0.004
Brugia malayi SRC-1 0.0018 0.0081 0.0102
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0011 0.0032 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0175 0.0221
Echinococcus granulosus natriuretic peptide receptor 1 0.0018 0.0081 0.0081
Schistosoma mansoni survival motor neuron protein 0.0049 0.0331 0.0419
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0032 0.0032
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0018 0.0081 0.022
Echinococcus multilocularis kinase suppressor of Ras 1 0.0018 0.0081 0.0081
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Brugia malayi Tyrosine-protein kinase abl-1 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0095 0.07 0.0886
Leishmania major importin beta-1 subunit, putative 0.0024 0.0134 0.0377
Echinococcus multilocularis insulin receptor 0.0018 0.0081 0.0081
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0018 0.0081 0.0102
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0088 0.0088
Echinococcus multilocularis snurportin 1 0.032 0.2493 0.2493
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.2493 0.3156
Echinococcus granulosus activated cdc42 kinase 1 0.0018 0.0081 0.0081
Plasmodium vivax SET domain protein, putative 0.0029 0.0175 0.9534
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Schistosoma mansoni neuropeptide receptor 0.0011 0.0032 0.004
Schistosoma mansoni hypothetical protein 0.0018 0.0081 0.0102
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0011 0.0032 0.004
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Onchocerca volvulus 0.0011 0.0032 0.0087
Schistosoma mansoni hypothetical protein 0.0049 0.0331 0.0419
Echinococcus multilocularis tyrosine protein kinase Abl 0.0018 0.0081 0.0081
Echinococcus granulosus orexin receptor type 2 0.0011 0.0032 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Onchocerca volvulus 0.0018 0.0081 0.022
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0018 0.0081 0.0102
Schistosoma mansoni ap endonuclease 0.0019 0.0088 0.0111
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0018 0.0081 0.0081
Brugia malayi protein-tyrosine kinase 0.0018 0.0081 0.0102
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0071 0.0071
Brugia malayi Pre-SET motif family protein 0.0029 0.0175 0.0221
Echinococcus granulosus serotonin receptor 0.0011 0.0032 0.0032
Trypanosoma brucei protein kinase, putative 0.002 0.01 0.0637
Echinococcus multilocularis mitogen activated protein kinase 14 0.013 0.0978 0.0978
Schistosoma mansoni hypothetical protein 0.0349 0.272 0.3443
Brugia malayi Dopamine receptor protein 2 0.0011 0.0032 0.004
Brugia malayi integrin-linked kinase 0.0018 0.0081 0.0102
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0011 0.0032 0.004
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0018 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.009
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0179 1
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0018 0.0081 0.0081
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Echinococcus granulosus c src tyrosine kinase 0.0018 0.0081 0.0081
Brugia malayi hypothetical protein 0.0011 0.0032 0.004
Schistosoma mansoni ephrin receptor 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0102
Echinococcus multilocularis dual specificity testis specific protein kinase 0.002 0.01 0.01
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0102 0.0753 0.5007
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0196 0.15 1
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0032 0.0032
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0018 0.0081 0.0102
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0088 0.0051
Echinococcus multilocularis tyrosine protein kinase csk 0.0018 0.0081 0.0081
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0011 0.0032 0.0032
Brugia malayi Pre-SET motif family protein 0.0205 0.1575 0.1994
Echinococcus granulosus neuropeptide receptor A26 0.0011 0.0032 0.0032
Echinococcus multilocularis tyrosine protein kinase csk 0.0018 0.0081 0.0081
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0011 0.0032 0.004
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0011 0.0032 0.004
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0011 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Schistosoma mansoni serine/threonine RGC 0.0018 0.0081 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0032 0.004
Schistosoma mansoni adenoreceptor 0.0011 0.0032 0.004
Brugia malayi C-terminal src kinase protein 1 0.0018 0.0081 0.0102
Echinococcus granulosus alpha 1A adrenergic receptor 0.0011 0.0032 0.0032
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Echinococcus granulosus biogenic amine 5HT receptor 0.0011 0.0032 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0032 0.004
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0116 0.3602
Onchocerca volvulus 0.0011 0.0032 0.0087
Echinococcus multilocularis neuropeptide Y receptor 0.0011 0.0032 0.0032
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0018 0.0081 0.0081
Schistosoma mansoni ran 0.0022 0.0116 0.0147
Brugia malayi P38 map kinase family protein 2 0.013 0.0978 0.1238
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0088 0.5
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0166 0.0166
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0196 0.15 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Schistosoma mansoni hypothetical protein 0.0035 0.0223 0.0282
Brugia malayi hypothetical protein 0.0018 0.0081 0.0102
Echinococcus multilocularis protein tyrosine kinase 0.0018 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.0147
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0018 0.0081 0.0081
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Schistosoma mansoni ran 0.0022 0.0116 0.0147
Loa Loa (eye worm) TK protein kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0018 0.0081 0.0081
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0223 0.0282
Brugia malayi hypothetical protein 0.0011 0.0032 0.004
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0011 0.0032 0.004
Brugia malayi neuropeptide F receptor 0.0011 0.0032 0.004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.002 0.01 0.0139
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0088 0.0042
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Echinococcus granulosus tyrosine protein kinase Fyn 0.0018 0.0081 0.0081
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0116 0.0116
Schistosoma mansoni biogenic amine (5HT) receptor 0.0011 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0102
Brugia malayi hypothetical protein 0.0035 0.0223 0.0282
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0223 0.0282
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Onchocerca volvulus Neuropeptide F receptor homolog 0.0011 0.0032 0.0087
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0011 0.0032 0.004
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0032 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Onchocerca volvulus 0.0011 0.0032 0.0087
Brugia malayi Receptor family ligand binding region containing protein 0.0018 0.0081 0.0102
Brugia malayi hypothetical protein 0.0011 0.0032 0.004
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0018 0.0081 0.0081
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0116 0.0743
Brugia malayi ephrin receptor 1 precursor 0.0018 0.0081 0.0102
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0018 0.0081 0.0102
Entamoeba histolytica protein kinase, putative 0.0018 0.0081 0.00000069082
Echinococcus granulosus g protein coupled receptor 0.0011 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase csk 0.0018 0.0081 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0032 0.004
Brugia malayi Serotonin receptor 0.0011 0.0032 0.004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0071 0.0071
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Loa Loa (eye worm) TK protein kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0018 0.0081 0.0081
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0011 0.0032 0.0032
Schistosoma mansoni histamine h1 receptor 0.0011 0.0032 0.004
Echinococcus multilocularis g-protein coupled receptor 0.0011 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0018 0.0081 0.0102
Schistosoma mansoni protein kinase 0.002 0.01 0.0127
Trichomonas vaginalis TKL family protein kinase 0.0018 0.0081 0.000000057095
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0018 0.0081 0.0102
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0071 0.009
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0018 0.0081 0.0102
Echinococcus granulosus dual specificity testis-specific protein kinase 0.002 0.01 0.01
Echinococcus multilocularis protein kinase 0.0018 0.0081 0.0081
Echinococcus granulosus hypothetical protein 0.0011 0.0032 0.0032
Echinococcus multilocularis transfer RNA-Thr 0.0018 0.0081 0.0081
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0081 0.0102
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0998 0.7899 0.7899
Echinococcus granulosus insulin receptor 0.0018 0.0081 0.0081
Onchocerca volvulus 0.0011 0.0032 0.0087
Brugia malayi SH2 domain containing protein 0.0018 0.0081 0.0102
Echinococcus granulosus tachykinin peptides receptor 99D 0.0011 0.0032 0.0032
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0032 0.0032
Loa Loa (eye worm) TK protein kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0175 0.0175
Echinococcus multilocularis natriuretic peptide receptor 1 0.0018 0.0081 0.0081
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0011 0.0032 0.0032
Echinococcus multilocularis importin subunit beta 1 0.003 0.0179 0.0179
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0018 0.0081 0.0081
Echinococcus granulosus g protein coupled receptor 0.0011 0.0032 0.0032
Echinococcus multilocularis receptor type guanylyl cyclase 0.0018 0.0081 0.0081
Onchocerca volvulus 0.0049 0.0331 0.0902
Loa Loa (eye worm) TK protein kinase 0.0018 0.0081 0.0102
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0354 0.0448
Loa Loa (eye worm) RGC/RGC protein kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis tyrosine protein kinase 0.0018 0.0081 0.0081
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0032 0.0032
Loa Loa (eye worm) TK/INSR protein kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0032 0.004
Echinococcus multilocularis epidermal growth factor receptor 0.0018 0.0081 0.0081
Brugia malayi larval opioid receptor 0.0011 0.0032 0.004
Brugia malayi neuropeptide F receptor 0.0011 0.0032 0.004
Echinococcus multilocularis neuropeptide FF receptor 2 0.0011 0.0032 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Echinococcus granulosus sex peptide receptor 0.0011 0.0032 0.0032
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0018 0.0081 0.0081
Schistosoma mansoni amine GPCR 0.0011 0.0032 0.004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0223 0.0223
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1575 0.1994
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0088 0.0051
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Onchocerca volvulus 0.0018 0.0081 0.022
Schistosoma mansoni amine GPCR 0.0011 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.024 0.1858 0.2352
Onchocerca volvulus 0.0018 0.0081 0.022
Echinococcus multilocularis g protein coupled receptor 0.0011 0.0032 0.0032
Echinococcus multilocularis serotonin receptor 0.0011 0.0032 0.0032
Echinococcus multilocularis mitogen activated protein kinase 11 0.013 0.0978 0.0978
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0146 0.0184
Echinococcus multilocularis tyrosine kinase 0.0018 0.0081 0.0081
Schistosoma mansoni protein kinase 0.0018 0.0081 0.0102
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.009
Brugia malayi hypothetical protein 0.0018 0.0081 0.0102
Loa Loa (eye worm) TK/ALK protein kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) TK protein kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.013 0.0978 0.6323
Echinococcus multilocularis dro:myosuppressin receptor 0.0011 0.0032 0.0032
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0018 0.0081 0.0102
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0032 0.004
Schistosoma mansoni vesicular acetylcholine transporter 0.0468 0.3674 0.4651
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.0147
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Schistosoma mansoni amine GPCR 0.0011 0.0032 0.004
Loa Loa (eye worm) TK/EPH protein kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) TYRA-2 protein 0.0011 0.0032 0.004
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Echinococcus granulosus importin subunit beta 1 0.003 0.0179 0.0179
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0116 0.025
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0011 0.0032 0.0032
Onchocerca volvulus 0.0011 0.0032 0.0087
Loa Loa (eye worm) TK/ABL protein kinase 0.0018 0.0081 0.0102
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0088 0.5
Echinococcus granulosus geminin 0.0349 0.272 0.272
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0018 0.0081 0.0102
Brugia malayi hypothetical protein 0.0011 0.0032 0.004
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0011 0.0032 0.0032
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0196 0.15 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0102
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0018 0.0081 0.0081
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0018 0.0081 0.000000057095
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0032 0.004
Brugia malayi hypothetical protein 0.0011 0.0032 0.004
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0018 0.0081 0.0081
Brugia malayi hypothetical protein 0.0011 0.0032 0.004
Schistosoma mansoni opsin-like receptor 0.0011 0.0032 0.004
Schistosoma mansoni myosin xvIII 0.0011 0.0032 0.004
Echinococcus multilocularis heat shock protein 70 0.0018 0.0081 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0081 0.0102
Schistosoma mansoni hypothetical protein 0.0011 0.0032 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Loa Loa (eye worm) G-protein coupled receptor 0.0011 0.0032 0.004
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Echinococcus granulosus neuropeptide receptor 0.0011 0.0032 0.0032
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0032 0.0032
Echinococcus granulosus fmrfamide receptor 0.0011 0.0032 0.0032
Schistosoma mansoni protein kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0102
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0018 0.0081 0.0081
Echinococcus multilocularis protein KINase family member (kin 25) 0.0018 0.0081 0.0081
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0029 0.0175 0.0221
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0018 0.0081 0.0081
Echinococcus granulosus neuropeptide s receptor 0.0011 0.0032 0.0032
Echinococcus multilocularis allatostatin A receptor 0.0011 0.0032 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0032 0.004
Trichomonas vaginalis TKL family protein kinase 0.0018 0.0081 0.000000057095
Brugia malayi putative neuropeptide receptor 0.0011 0.0032 0.004
Schistosoma mansoni protein kinase 0.002 0.01 0.0127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Onchocerca volvulus 0.0011 0.0032 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Schistosoma mansoni protein tyrosine kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0018 0.0081 0.0081
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0018 0.0081 0.0081
Plasmodium falciparum importin beta, putative 0.003 0.0179 1
Brugia malayi SH2 domain containing protein 0.0018 0.0081 0.0102
Loa Loa (eye worm) TK protein kinase 0.0018 0.0081 0.0102
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0088 0.0514
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Brugia malayi Melatonin receptor type 1A 0.0011 0.0032 0.004
Echinococcus granulosus neuropeptide Y receptor 0.0011 0.0032 0.0032
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0071 0.0071
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0081 0.0102
Brugia malayi G-protein coupled receptor 0.0011 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0018 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Schistosoma mansoni tyrosine protein kinase 0.0018 0.0081 0.0102
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0018 0.0081 0.0102
Brugia malayi hypothetical protein 0.0011 0.0032 0.004
Onchocerca volvulus 0.0018 0.0081 0.022
Loa Loa (eye worm) TK protein kinase 0.0018 0.0081 0.0102
Brugia malayi hypothetical protein 0.0018 0.0081 0.0102
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis tyrosine protein kinase Srms 0.0018 0.0081 0.0081
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0088 0.0111
Schistosoma mansoni biogenic amine receptor 0.0011 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Brugia malayi RNA, U transporter 1 0.0085 0.062 0.0785
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 0.3602
Loa Loa (eye worm) RGC/RGC protein kinase 0.0018 0.0081 0.0102
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Onchocerca volvulus 0.0011 0.0032 0.0087
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Loa Loa (eye worm) TK/FAK protein kinase 0.0018 0.0081 0.0102
Echinococcus granulosus neuropeptide receptor 0.0011 0.0032 0.0032
Onchocerca volvulus 0.0018 0.0081 0.022
Trichomonas vaginalis ran, putative 0.0022 0.0116 0.0207
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0116 0.025
Brugia malayi ORL1-like opioid receptor 0.0011 0.0032 0.004
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Echinococcus granulosus protein tyrosine kinase 0.0018 0.0081 0.0081
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Brugia malayi hypothetical protein 0.0011 0.0032 0.004
Onchocerca volvulus 0.0018 0.0081 0.022
Loa Loa (eye worm) TK protein kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Onchocerca volvulus 0.0011 0.0032 0.0087
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0088 0.074
Onchocerca volvulus 0.0011 0.0032 0.0087
Echinococcus multilocularis tyrosine kinase 0.0018 0.0081 0.0081
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0018 0.0081 0.0081
Echinococcus granulosus tyrosine protein kinase Srms 0.0018 0.0081 0.0081
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Echinococcus granulosus somatostatin receptor 0.0011 0.0032 0.0032
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0018 0.0081 0.0081
Echinococcus granulosus dro:myosuppressin receptor 0.0011 0.0032 0.0032
Echinococcus granulosus protein kinase 0.0018 0.0081 0.0081
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0018 0.0081 0.022
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.013 0.0978 0.6323
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0032 0.004
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0011 0.0032 0.004
Schistosoma mansoni hypothetical protein 0.0011 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Echinococcus multilocularis epidermal growth factor receptor 0.0018 0.0081 0.0081
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0011 0.0032 0.0032
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.002 0.01 0.0139
Echinococcus multilocularis serotonin receptor 0.0011 0.0032 0.0032
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0011 0.0032 0.0032
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.013 0.0978 0.6509
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0018 0.0081 0.0081
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Echinococcus granulosus epidermal growth factor receptor 0.0018 0.0081 0.0081
Schistosoma mansoni serine/threonine protein kinase 0.0998 0.7899 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0011 0.0032 0.004
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0175 0.0221
Echinococcus granulosus integrin linked protein kinase 0.0018 0.0081 0.0081
Echinococcus granulosus neuropeptides capa receptor 0.0011 0.0032 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Echinococcus granulosus retinal guanylyl cyclase 2 0.0018 0.0081 0.0081
Echinococcus multilocularis geminin 0.0349 0.272 0.272
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Schistosoma mansoni biogenic amine receptor 0.0011 0.0032 0.004
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0088 0.0554
Brugia malayi follicle stimulating hormone receptor 0.0011 0.0032 0.004
Schistosoma mansoni ap endonuclease 0.0019 0.0088 0.0111
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0018 0.0081 0.0081
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0011 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0223 0.0282
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0134 0.0311
Loa Loa (eye worm) RGC/RGC protein kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.003 0.0179 0.0227
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0134 0.0377
Brugia malayi G protein-coupled receptor 0.0011 0.0032 0.004
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.1858 0.1858
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0011 0.0032 0.004
Echinococcus granulosus fibroblast growth factor receptor 4 0.0018 0.0081 0.0081
Echinococcus multilocularis neuropeptide receptor A26 0.0011 0.0032 0.0032
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0071 0.009
Brugia malayi sulfakinin receptor protein 0.0011 0.0032 0.004
Onchocerca volvulus 0.0011 0.0032 0.0087
Schistosoma mansoni protein kinase 0.0018 0.0081 0.0102
Schistosoma mansoni ephrin receptor 0.0018 0.0081 0.0102
Schistosoma mansoni neuropeptide receptor 0.0011 0.0032 0.004
Loa Loa (eye worm) neuropeptide F receptor 0.0011 0.0032 0.004
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.002 0.01 0.1992
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0116 0.3602
Echinococcus multilocularis rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Schistosoma mansoni protein kinase 0.002 0.01 0.0127
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0018 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0052 0.0354 0.0448
Echinococcus granulosus 7tm_1 domain containing protein 0.0011 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase Fyn 0.0018 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0102
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0088 0.0111
Echinococcus granulosus tyrosine kinase 0.0018 0.0081 0.0081
Echinococcus granulosus tyrosine protein kinase Fyn 0.0018 0.0081 0.0081
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis activin receptor type 0.002 0.01 0.01
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0011 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase Lyn 0.002 0.01 0.01
Echinococcus granulosus tyrosine protein kinase HCK 0.0018 0.0081 0.0081
Echinococcus multilocularis neuropeptides capa receptor 0.0011 0.0032 0.0032
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0011 0.0032 0.0032
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0018 0.0081 0.0081
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0179 0.1166
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0011 0.0032 0.004
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0011 0.0032 0.004
Loa Loa (eye worm) serine/threonine protein kinase 0.0018 0.0081 0.0102
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0018 0.0081 0.0102
Echinococcus multilocularis GPCR, family 2 0.0016 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Onchocerca volvulus Tyrosine kinase homolog 0.0018 0.0081 0.022
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Echinococcus granulosus receptor type guanylyl cyclase 0.0018 0.0081 0.0081
Schistosoma mansoni biogenic amine receptor 0.0011 0.0032 0.004
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Brugia malayi RE15519p 0.0011 0.0032 0.004
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0088 0.074
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.013 0.0978 0.1238
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Echinococcus granulosus mitogen activated protein kinase 11 0.013 0.0978 0.0978
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Entamoeba histolytica hypothetical protein 0.0035 0.0223 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0011 0.0032 0.004
Onchocerca volvulus 0.0018 0.0081 0.022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0018 0.0081 0.0102
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0018 0.0081 0.0081
Onchocerca volvulus 0.0233 0.1801 0.4902
Onchocerca volvulus 0.0018 0.0081 0.022
Entamoeba histolytica hypothetical protein 0.0024 0.0134 0.3758
Echinococcus granulosus tyrosine protein kinase ABL1 0.0018 0.0081 0.0081
Onchocerca volvulus 0.0011 0.0032 0.0087
Schistosoma mansoni hypothetical protein 0.032 0.2493 0.3156
Trichomonas vaginalis TKL family protein kinase 0.0018 0.0081 0.000000057095
Plasmodium falciparum protein kinase, putative 0.002 0.01 0.1992
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0018 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0102
Echinococcus granulosus allatostatin A receptor 0.0011 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Onchocerca volvulus 0.0011 0.0032 0.0087
Echinococcus granulosus G protein coupled receptor 139 0.0011 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0102
Schistosoma mansoni opsin-like receptor 0.0011 0.0032 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0032 0.004
Brugia malayi Raf kinase 0.0018 0.0081 0.0102
Onchocerca volvulus 0.0018 0.0081 0.022
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0175 0.9534
Brugia malayi GnHR receptor homolog 0.0011 0.0032 0.004
Entamoeba histolytica hypothetical protein 0.0035 0.0223 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.013 0.0978 0.0978
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0018 0.0081 0.0102
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0116 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0102
Loa Loa (eye worm) SRC-1 0.0018 0.0081 0.0102
Schistosoma mansoni protein kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis G-protein coupled receptor, putative 0.0011 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Echinococcus granulosus c-Jun N-terminal kinases 0.0998 0.7899 0.7899
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Echinococcus granulosus tyrosine kinase 0.0018 0.0081 0.0081
Onchocerca volvulus 0.0018 0.0081 0.022
Onchocerca volvulus 0.0018 0.0081 0.022
Brugia malayi Dopamine receptor protein 1 0.0011 0.0032 0.004
Schistosoma mansoni tyrosine kinase 0.0018 0.0081 0.0102
Leishmania major GTP-binding protein, putative 0.0022 0.0116 0.025
Loa Loa (eye worm) TK/EGFR protein kinase 0.0018 0.0081 0.0102
Echinococcus granulosus ephrin type A receptor 4 A 0.0018 0.0081 0.0081
Brugia malayi Cytochrome P450 family protein 0.0026 0.0146 0.0184
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Entamoeba histolytica hypothetical protein 0.0035 0.0223 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0088 0.5
Loa Loa (eye worm) TK protein kinase 0.0018 0.0081 0.0102
Schistosoma mansoni hypothetical protein 0.0011 0.0032 0.004
Schistosoma mansoni hypothetical protein 0.0011 0.0032 0.004
Brugia malayi hypothetical protein 0.0011 0.0032 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis orexin receptor type 2 0.0011 0.0032 0.0032
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0018 0.0081 0.0081
Onchocerca volvulus 0.0011 0.0032 0.0087
Echinococcus multilocularis G protein coupled receptor 139 0.0011 0.0032 0.0032
Schistosoma mansoni neuropeptide receptor 0.0011 0.0032 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0018 0.0081 0.0081
Echinococcus granulosus tm gpcr rhodopsin 0.0011 0.0032 0.0032
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0095 0.07 0.0886
Echinococcus multilocularis fmrfamide receptor 0.0011 0.0032 0.0032
Schistosoma mansoni neuropeptide F-like receptor 0.0011 0.0032 0.004
Echinococcus granulosus tyrosine kinase 0.0018 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Echinococcus granulosus snurportin 1 0.032 0.2493 0.2493
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0071 0.0071
Echinococcus granulosus activin receptor type 0.002 0.01 0.01
Onchocerca volvulus 0.0018 0.0081 0.022
Loa Loa (eye worm) TK/FER protein kinase 0.0018 0.0081 0.0102
Echinococcus granulosus tyrosine protein kinase Src42A 0.0018 0.0081 0.0081
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0179 0.1166
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0018 0.0081 0.0102
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.004
Entamoeba histolytica protein kinase, putative 0.0018 0.0081 0.00000069082
Trichomonas vaginalis set domain proteins, putative 0.0233 0.1801 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0018 0.0081 0.0081
Echinococcus granulosus neuropeptide FF receptor 2 0.0011 0.0032 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0011 0.0032 0.004
Brugia malayi hypothetical protein 0.024 0.1858 0.2352
Echinococcus granulosus mitogen activated protein kinase 14 0.013 0.0978 0.0978
Onchocerca volvulus 0.0018 0.0081 0.022
Loa Loa (eye worm) TK/Met protein kinase 0.0018 0.0081 0.0102
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.013 0.0978 0.6323
Echinococcus multilocularis c src tyrosine kinase 0.0018 0.0081 0.0081
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0018 0.0081 0.0081
Echinococcus multilocularis tyrosine protein kinase csk 0.0018 0.0081 0.0081
Echinococcus granulosus kinase suppressor of Ras 1 0.0018 0.0081 0.0081
Brugia malayi Stress-activated protein kinase jnk-1 0.0998 0.7899 1
Entamoeba histolytica hypothetical protein 0.0035 0.0223 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0018 0.0081 0.0081
Echinococcus granulosus g protein coupled receptor 0.0011 0.0032 0.0032
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0011 0.0032 0.004
Brugia malayi Protein kinase domain containing protein 0.0018 0.0081 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0175 0.0221
Loa Loa (eye worm) TK/ACK protein kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0018 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0102
Loa Loa (eye worm) protein kinase domain-containing protein 0.0018 0.0081 0.0102
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0011 0.0032 0.004
Brugia malayi bone morphogenetic protein type 1 receptor 0.0018 0.0081 0.0102
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0018 0.0081 0.0081
Schistosoma mansoni protein kinase 0.0018 0.0081 0.0102
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0088 0.0088
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0018 0.0081 0.0102
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0018 0.0081 0.0081
Echinococcus granulosus rhodopsin orphan GPCR 0.0011 0.0032 0.0032
Schistosoma mansoni importin beta-1 0.003 0.0179 0.0227
Echinococcus multilocularis somatostatin receptor 0.0011 0.0032 0.0032
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0011 0.0032 0.0032
Loa Loa (eye worm) TK/RYK protein kinase 0.0018 0.0081 0.0102
Echinococcus multilocularis activated cdc42 kinase 1 0.0018 0.0081 0.0081
Onchocerca volvulus 0.0018 0.0081 0.022
Echinococcus multilocularis protein kinase 0.0018 0.0081 0.0081

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4.97 Displacement of [3H]Deltorphin from DOR in Sprague-Dawley rat brain membrane after 180 mins by scintillation counting analysis ChEMBL. 23547584
IC50 (binding) = 6.42 Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membrane after 180 mins by scintillation counting analysis ChEMBL. 23547584
IC50 (binding) = 1300 nM Inhibition of DOR in ICR mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction after 3 mins ChEMBL. 23547584
Inhibition (binding) = 9.2 % Inhibition of MOR in Hartley guinea pig ileum longitudinal muscle myenteric plexus assessed as inhibition of electrically-stimulated muscle contraction at 1 uM after 3 mins ChEMBL. 23547584
Ki (binding) = 172 nM Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membrane after 180 mins by scintillation counting analysis ChEMBL. 23547584
Ki (binding) = 240 nM Displacement of [3H]Deltorphin from DOR in Sprague-Dawley rat brain membrane after 180 mins by scintillation counting analysis ChEMBL. 23547584

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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