Detailed information for compound 1731711

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 264.709 | Formula: C16H9ClN2
  • H donors: 0 H acceptors: 2 LogP: 3.84 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc2c1ccc(n2)C#Cc1ccccn1
  • InChi: 1S/C16H9ClN2/c17-15-5-3-6-16-14(15)10-9-13(19-16)8-7-12-4-1-2-11-18-12/h1-6,9-11H
  • InChiKey: BVNCVGWDWJCVNB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major trypanothione reductase 0.0039 0.0129 0.2577
Echinococcus multilocularis tumor protein p63 0.1797 1 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.008 0.0356 0.8633
Onchocerca volvulus Putative transporter 0.0041 0.0139 0.0497
Loa Loa (eye worm) MH2 domain-containing protein 0.0438 0.2366 0.9145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0264 0.1697
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0048 0.0177 0.3769
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0294 0.1557 0.1557
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0063 0.0402
Echinococcus multilocularis GPCR, family 2 0.0069 0.0295 0.0295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0241 0.1548
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Brugia malayi Bromodomain containing protein 0.0051 0.0196 0.0758
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Loa Loa (eye worm) phosphatidylinositol 3 0.0027 0.0058 0.0224
Toxoplasma gondii target of rapamycin (TOR), putative 0.0059 0.0241 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0149 0.0958
Schistosoma mansoni protein kinase 0.009 0.0412 0.2648
Brugia malayi Sugar transporter family protein 0.0041 0.0139 0.0539
Onchocerca volvulus 0.0028 0.0063 0.0199
Plasmodium vivax sugar transporter, putative 0.0041 0.0139 0.0201
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0088 0.0402 0.858
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0048 0.0177 0.1135
Onchocerca volvulus 0.0041 0.0139 0.0497
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0066 0.0276 0.5517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0264 0.1697
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.009 0.0412 0.0412
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0041 0.0139 0.2969
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0002 0.0011
Brugia malayi Major Facilitator Superfamily protein 0.0041 0.0139 0.0539
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Echinococcus multilocularis lamin 0.0048 0.0174 0.0174
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0103 0.0486 0.0486
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0002 0.001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0257 0.1648
Trypanosoma brucei unspecified product 0.0033 0.0093 0.1863
Schistosoma mansoni TGF-beta signal transducer Smad2 0.003 0.0075 0.048
Echinococcus multilocularis dna polymerase kappa 0.0048 0.0177 0.0177
Loa Loa (eye worm) cysteine protease 0.0028 0.0063 0.0243
Brugia malayi Sugar transporter family protein 0.0294 0.1557 0.6019
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0356 0.2286
Brugia malayi Cathepsin L-like precursor 0.0019 0.0011 0.0044
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0066 0.0276 0.5517
Trichomonas vaginalis sugar transporter, putative 0.0091 0.0419 0.269
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0048 0.0177 0.0177
Brugia malayi Cathepsin L-like precursor 0.0028 0.0063 0.0243
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.008 0.0356 0.0356
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0063 0.0402
Trypanosoma cruzi hexose transporter, putative 0.0091 0.0419 0.839
Onchocerca volvulus 0.0041 0.0139 0.0497
Brugia malayi Cathepsin L-like cysteine proteinase 0.0019 0.0011 0.0044
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0001 0.0007
Leishmania major lysyl-tRNA synthetase, putative 0.0066 0.0276 0.5517
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.0177 0.3539
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0025 0.0055
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0088 0.0402 0.0402
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.008 0.0356 0.0356
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0027 0.0058 0.1156
Toxoplasma gondii sugar transporter ST1 0.0041 0.0139 0.0305
Echinococcus granulosus cathepsin L cysteine proteinase 0.0028 0.0063 0.0063
Toxoplasma gondii sugar transporter ST3 0.0041 0.0139 0.0305
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0041 0.0139 0.0139
Schistosoma mansoni hypothetical protein 0.0069 0.0295 0.1893
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0356 0.2286
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.0412 0.8797
Loa Loa (eye worm) sugar transporter 0.0041 0.0139 0.0539
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0028 0.0063 0.0091
Schistosoma mansoni jumonji domain containing protein 0.0134 0.0658 0.4228
Onchocerca volvulus Phospholipase A2 homolog 0.0087 0.0395 0.1491
Brugia malayi cytoplasmic intermediate filament protein 0.0025 0.005 0.0195
Schistosoma mansoni sugar transporter 0.0041 0.0139 0.0894
Onchocerca volvulus 0.0041 0.0139 0.0497
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.0412 0.8797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0264 0.1697
Schistosoma mansoni terminal deoxycytidyl transferase 0.0048 0.0177 0.1135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0011 0.0072
Echinococcus granulosus calcium dependent protein kinase 0.0084 0.0381 0.0381
Brugia malayi hypothetical protein 0.0041 0.0139 0.0539
Toxoplasma gondii lysine-tRNA ligase 0.0066 0.0276 0.0603
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0499 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0063 0.0402
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.009 0.0413 0.0903
Onchocerca volvulus 0.0041 0.0139 0.0497
Brugia malayi Latrophilin receptor protein 2 0.0069 0.0295 0.114
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Onchocerca volvulus 0.0041 0.0139 0.0497
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.0295 0.0295
Onchocerca volvulus 0.0028 0.0063 0.0199
Loa Loa (eye worm) Smad1 0.003 0.0075 0.0289
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0041 0.0139 0.5052
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Onchocerca volvulus 0.0041 0.0139 0.0497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0063 0.0402
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Trichomonas vaginalis sugar transporter, putative 0.0091 0.0419 0.269
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Plasmodium falciparum protein kinase 7 0.083 0.4568 0.6612
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.008 0.0356 0.7131
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0088 0.0402 0.2583
Onchocerca volvulus 0.0028 0.0063 0.0199
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0475 0.2573 0.3724
Echinococcus granulosus solute carrier family 22 0.0041 0.0139 0.0139
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0017 0.0002 0.0031
Brugia malayi MH2 domain containing protein 0.003 0.0075 0.0289
Echinococcus multilocularis cysteine protease 0.0028 0.0063 0.0063
Plasmodium falciparum glutathione reductase 0.0039 0.0129 0.0186
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.009 0.0412 0.0412
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0001 0.0001
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.0469 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0149 0.0958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.015 0.096
Loa Loa (eye worm) hypothetical protein 0.0022 0.0031 0.0121
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Echinococcus granulosus cathepsin l cysteine peptidase 0.0028 0.0063 0.0063
Echinococcus granulosus mothers against decapentaplegic 5 0.003 0.0075 0.0075
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0002
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0002 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0063 0.0402
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0017 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0173 0.1109
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Schistosoma mansoni hypothetical protein 0.0103 0.0486 0.3121
Leishmania major cathepsin L-like protease 0.0028 0.0063 0.1253
Echinococcus granulosus peregrin 0.0051 0.0196 0.0196
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.0412 0.8797
Toxoplasma gondii cathepsin CPL 0.0028 0.0063 0.0137
Entamoeba histolytica hypothetical protein 0.0034 0.0098 0.2376
Echinococcus multilocularis calcium dependent protein kinase 0.0084 0.0381 0.0381
Onchocerca volvulus 0.0041 0.0139 0.0497
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0103 0.0486 0.0486
Toxoplasma gondii protein kinase, putative 0.083 0.4568 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0066 0.0276 0.1769
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0063 0.0402
Echinococcus multilocularis thyroid hormone receptor alpha 0.0111 0.0532 0.0532
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0025 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0063 0.0402
Leishmania major cathepsin L-like protease 0.0028 0.0063 0.1253
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0139 0.0894
Trichomonas vaginalis myo-inositol transporter, putative 0.0041 0.0139 0.0894
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0001 0.0002
Schistosoma mansoni sugar transporter 0.0041 0.0139 0.0894
Trypanosoma brucei DNA polymerase IV, putative 0.0048 0.0177 0.3539
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0129 0.2744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0176 0.1126
Plasmodium vivax proline--tRNA ligase, putative 0.0103 0.0484 0.0701
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0001 0.0007
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.009 0.0412 0.1595
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Entamoeba histolytica hypothetical protein 0.0034 0.0098 0.2376
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0001 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0499 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0218 0.1132 0.4376
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0063 0.1517
Toxoplasma gondii sugar transporter ST2 0.0041 0.0139 0.0305
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0088 0.0402 0.0402
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0088 0.0402 0.1555
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0063 0.0402
Mycobacterium ulcerans sugar transporter 0.0041 0.0139 0.5052
Leishmania major phosphatidylinositol 3-kinase, putative 0.0027 0.0058 0.1156
Onchocerca volvulus 0.0263 0.1385 0.5332
Onchocerca volvulus Alhambra homolog 0.0051 0.0196 0.0717
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.0295 0.114
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0499 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.0295 0.0295
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.009 0.0413 0.0597
Leishmania major cathepsin L-like protease 0.0028 0.0063 0.1253
Schistosoma mansoni sugar transporter 0.0041 0.0139 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Plasmodium vivax vivapain-2 0.0028 0.0063 0.0091
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0017 0.0002 0.0003
Brugia malayi Thioredoxin reductase 0.0039 0.0129 0.0498
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0028 0.0063 0.0402
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0129 0.0186
Entamoeba histolytica hypothetical protein 0.0066 0.0276 0.6679
Loa Loa (eye worm) PHD-finger family protein 0.0051 0.0196 0.0758
Mycobacterium ulcerans integral membrane transport protein 0.0041 0.0139 0.5052
Trypanosoma brucei DNA polymerase IV, putative 0.0048 0.0177 0.3539
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0098
Plasmodium falciparum phd finger protein, putative 0.0051 0.0196 0.0283
Brugia malayi glutathione reductase 0.0039 0.0129 0.0498
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.009 0.0412 0.0412
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0056 0.022 0.4692
Schistosoma mansoni hypothetical protein 0.0051 0.0196 0.1258
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0011 0.0072
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0028 0.0063 0.0243
Brugia malayi MH1 domain containing protein 0.003 0.0075 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0028 0.0063 0.0402
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Echinococcus granulosus lamin dm0 0.0048 0.0174 0.0174
Echinococcus granulosus lysyl tRNA synthetase 0.0066 0.0276 0.0275
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Trypanosoma cruzi sugar transporter, putative 0.0041 0.0139 0.2788
Brugia malayi Cathepsin L-like precursor 0.0028 0.0063 0.0243
Brugia malayi jmjC domain containing protein 0.0168 0.0853 0.3296
Leishmania major cathepsin L-like protease 0.0105 0.0499 1
Mycobacterium ulcerans DNA polymerase IV 0.0048 0.0177 0.6414
Leishmania major glucose transporter, lmgt3 0.0091 0.0419 0.839
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.008 0.0356 0.8633
Plasmodium vivax lysine--tRNA ligase, putative 0.0066 0.0276 0.0399
Entamoeba histolytica protein kinase, putative 0.009 0.0412 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.0412 0.8797
Brugia malayi Major Facilitator Superfamily protein 0.0041 0.0139 0.0539
Loa Loa (eye worm) major facilitator superfamily transporter 0.0041 0.0139 0.0539
Plasmodium vivax vivapain-2 0.0028 0.0063 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0419 0.269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0063 0.0402
Onchocerca volvulus 0.0041 0.0139 0.0497
Trypanosoma brucei glucose transporter, putative 0.0091 0.0419 0.839
Mycobacterium tuberculosis Probable reductase 0.009 0.0412 0.8797
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0093 0.1863
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.009 0.0412 0.0412
Trypanosoma brucei glucose transporter, putative 0.0091 0.0419 0.839
Loa Loa (eye worm) intermediate filament protein 0.0048 0.0174 0.0674
Leishmania major myo-inositol/proton symporter (MIT) 0.0041 0.0139 0.2788
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0028 0.0063 0.0091
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0139 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.009 0.0412 0.0412
Plasmodium falciparum calcium-dependent protein kinase 2 0.009 0.0413 0.0597
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.0098 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0139 0.0894
Entamoeba histolytica cysteine protease, putative 0.0028 0.0063 0.1517
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0063 0.0402
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0017 0 0.0001
Echinococcus granulosus Smad4 0.003 0.0075 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0036 0.0111 0.0427
Trypanosoma brucei DNA polymerase IV, putative 0.0048 0.0177 0.3539
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0168 0.0853 0.0852
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0096 0.0448 0.8971
Treponema pallidum prolyl-tRNA synthetase 0.0031 0.0082 1
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0017 0 0.0001
Trypanosoma cruzi target of rapamycin kinase 3 0.0064 0.0265 0.5299
Echinococcus multilocularis cathepsin L cysteine protease 0.0028 0.0063 0.0063
Brugia malayi Cathepsin L-like precursor 0.0028 0.0063 0.0243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0063 0.0402
Trichomonas vaginalis DNA polymerase eta, putative 0.0048 0.0177 0.1135
Trypanosoma brucei glucose transporter 2A 0.0091 0.0419 0.839
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.009 0.0412 0.0412
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.009 0.0412 0.0412
Plasmodium falciparum lysine--tRNA ligase 0.0066 0.0276 0.0399
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Loa Loa (eye worm) phosphatidylinositol 3 0.008 0.0356 0.1377
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0041 0.0139 0.2969
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.008 0.0356 0.1377
Schistosoma mansoni sugar transporter 0.0041 0.0139 0.0894
Plasmodium vivax hypothetical protein, conserved 0.0051 0.0196 0.0283
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0025 0.0505
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0129 0.2577
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0048 0.0177 0.3539
Brugia malayi jmjC domain containing protein 0.0017 0.0001 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0264 0.1697
Schistosoma mansoni cellular tumor antigen P53 0.0263 0.1385 0.8893
Onchocerca volvulus 0.0041 0.0139 0.0497
Brugia malayi Major Facilitator Superfamily protein 0.0041 0.0139 0.0539
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0063 0.0402
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0057 0.023 0.1477
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Brugia malayi MH2 domain containing protein 0.0438 0.2366 0.9145
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0028 0.0063 0.0063
Onchocerca volvulus 0.0041 0.0139 0.0497
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.0295 0.114
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0139 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.015 0.096
Schistosoma mansoni lamin 0.0048 0.0174 0.1119
Trypanosoma cruzi hexose transporter, putative 0.0041 0.0139 0.2788
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0294 0.1557 0.1557
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0475 0.2573 0.5632
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0218 0.1132 0.4376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0499 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0174 0.0674
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Plasmodium falciparum calcium-dependent protein kinase 3 0.009 0.0413 0.0597
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0028 0.0063 0.0063
Brugia malayi AF-10 protein 0.0017 0.0002 0.0007
Entamoeba histolytica deoxycytidyl transferase, putative 0.0048 0.0177 0.4284
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.0412 0.8797
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0064 0.0265 0.5299
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0063 0.1517
Loa Loa (eye worm) transcription factor SMAD2 0.0438 0.2366 0.9145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0499 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Leishmania major hypothetical protein, conserved 0.0017 0.0001 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0063 0.0402
Echinococcus multilocularis mothers against decapentaplegic 5 0.003 0.0075 0.0075
Trichomonas vaginalis glucose transporter, putative 0.0091 0.0419 0.269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0499 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0063 0.0402
Echinococcus multilocularis solute carrier family 22 0.0041 0.0139 0.0139
Trypanosoma brucei sugar transporter, putative 0.0041 0.0139 0.2788
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0056 0.022 0.4692
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.009 0.0412 0.0412
Plasmodium vivax hexose transporter 0.0294 0.1557 0.2253
Echinococcus multilocularis solute carrier family 22 0.0041 0.0139 0.0139
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0412 0.2648
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0063 0.0402
Trypanosoma brucei glucose transporter, putative 0.0091 0.0419 0.839
Loa Loa (eye worm) hypothetical protein 0.0047 0.0169 0.0655
Echinococcus multilocularis solute carrier family 22 0.0041 0.0139 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0058 0.0371
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0294 0.1557 0.1557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0176 0.1126
Schistosoma mansoni glucose transport protein 0.0294 0.1557 1
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0001 0.0002
Trypanosoma brucei glucose transporter, putative 0.0091 0.0419 0.839
Leishmania major cysteine peptidase A (CPA) 0.0028 0.0063 0.1253
Echinococcus multilocularis PHD finger protein rhinoceros 0.0051 0.0196 0.0196
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.008 0.0356 0.7131
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0058 0.0224
Echinococcus granulosus intermediate filament protein 0.0048 0.0174 0.0174
Schistosoma mansoni smad1 5 8 and 0.003 0.0075 0.048
Trypanosoma brucei glucose transporter, putative 0.0091 0.0419 0.839
Plasmodium falciparum proline--tRNA ligase 0.0103 0.0484 0.0701
Echinococcus granulosus TGF beta signal transducer SmadC 0.003 0.0075 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0091 0.0419 0.269
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0011 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0058 0.0371
Echinococcus multilocularis solute carrier family 22 0.0041 0.0139 0.0139
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0027 0.0058 0.1156
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Trypanosoma brucei THT1 - hexose transporter, putative 0.0091 0.0419 0.839
Onchocerca volvulus 0.0041 0.0139 0.0497
Echinococcus multilocularis synaptic vesicle 2 protein 0.0041 0.0139 0.0139
Schistosoma mansoni smad 0.003 0.0075 0.048
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0066 0.0276 0.5877
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0149 0.0958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0176 0.1126
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0356 0.2286
Loa Loa (eye worm) glutathione reductase 0.0039 0.0129 0.0498
Giardia lamblia Lysyl-tRNA synthetase 0.0066 0.0276 0.6849
Plasmodium falciparum hexose transporter 0.0294 0.1557 0.2253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0068 0.029 0.1865
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0017 0.0002 0.0031
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0257 0.0257
Trypanosoma brucei trypanothione reductase 0.0039 0.0129 0.2577
Trypanosoma cruzi cruzipain precursor, putative 0.0105 0.0499 1
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0001 0.0002
Trypanosoma cruzi glucose transporter, putative 0.0041 0.0139 0.2788
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0025 0.0037
Schistosoma mansoni lysyl-tRNA synthetase 0.0066 0.0276 0.1769
Giardia lamblia PHD finger protein 15 0.0051 0.0196 0.487
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0017 0.0002 0.0002
Plasmodium falciparum mitogen-activated protein kinase 2 0.0475 0.2573 0.3724
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0041 0.0139 0.5052
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0001 0.0002
Brugia malayi Cathepsin L-like precursor 0.0028 0.0063 0.0243
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0129 0.0129
Leishmania major glucose transporter/membrane transporter D2, putative 0.0091 0.0419 0.839
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0025 0.0037
Leishmania major hypothetical protein, conserved 0.0041 0.0139 0.2788
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0063 0.0402
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.0295 0.0295
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0088 0.0402 0.9752
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0027 0.0058 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0173 0.1109
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Trichomonas vaginalis sugar transport protein, putative 0.0041 0.0139 0.0894
Loa Loa (eye worm) hypothetical protein 0.0477 0.2587 1
Brugia malayi jmjC domain containing protein 0.0017 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0066 0.0276 0.1065
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0075 0.0289
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Trichomonas vaginalis glucose transporter, putative 0.0041 0.0139 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0241 0.1548
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Plasmodium falciparum cysteine proteinase falcipain 3 0.0028 0.0063 0.0091
Leishmania major cathepsin L-like protease 0.0105 0.0499 1
Leishmania major cathepsin L-like protease 0.0028 0.0063 0.1253
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0103 0.0484 0.106
Trypanosoma cruzi hexose transporter 0.0091 0.0419 0.839
Echinococcus multilocularis dna polymerase eta 0.0048 0.0177 0.0177
Leishmania major DNA polymerase eta, putative 0.0048 0.0177 0.3539
Loa Loa (eye worm) hypothetical protein 0.0088 0.0402 0.1555
Echinococcus granulosus smad 0.003 0.0075 0.0075
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.0177 0.0683
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0028 0.0063 0.0243
Brugia malayi Cathepsin L-like precursor 0.0019 0.0011 0.0044
Brugia malayi hypothetical protein 0.0034 0.0098 0.0379
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0027 0.0058 0.1156
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0001 0.0001
Onchocerca volvulus 0.0028 0.0063 0.0199
Trypanosoma brucei THT1 - hexose transporter, putative 0.0091 0.0419 0.839
Trypanosoma brucei glucose transporter, putative 0.0091 0.0419 0.839
Echinococcus granulosus GPCR family 2 0.0069 0.0295 0.0295
Leishmania major glucose transporter, lmgt2 0.0091 0.0419 0.839
Mycobacterium tuberculosis Conserved hypothetical protein 0.0048 0.0177 0.3769
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0063 0.0402
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0294 0.1557 0.1557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0241 0.1548
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.0469 1
Schistosoma mansoni glucose transporter 0.0041 0.0139 0.0894
Entamoeba histolytica protein kinase, putative 0.009 0.0412 1
Trichomonas vaginalis conserved hypothetical protein 0.0294 0.1557 1
Loa Loa (eye worm) ctsf protein 0.0028 0.0063 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Trypanosoma cruzi cysteine peptidase, putative 0.0105 0.0499 1
Schistosoma mansoni thyroid hormone receptor 0.0111 0.0532 0.3419
Echinococcus granulosus cathepsin l1 0.0019 0.0011 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Onchocerca volvulus 0.0041 0.0139 0.0497
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0139 0.0894
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0023 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.015 0.096
Plasmodium vivax calcium-dependent protein kinase, putative 0.009 0.0413 0.0597
Schistosoma mansoni hypothetical protein 0.0069 0.0295 0.1893
Schistosoma mansoni hypothetical protein 0.0017 0.0002 0.001
Leishmania major glucose transporter, lmgt1 0.0091 0.0419 0.839
Plasmodium vivax JmjC domain containing protein 0.0017 0.0001 0.0001
Trichomonas vaginalis glucose transporter, putative 0.0091 0.0419 0.269
Onchocerca volvulus 0.0048 0.0174 0.0633
Onchocerca volvulus 0.0041 0.0139 0.0497
Leishmania major cathepsin L-like protease 0.0028 0.0063 0.1253
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Echinococcus multilocularis TGF beta signal transducer SmadC 0.003 0.0075 0.0075
Toxoplasma gondii transporter, major facilitator family protein 0.0041 0.0139 0.0305
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.009 0.0412 0.1595
Giardia lamblia Sugar-proton symporter 0.0041 0.0139 0.346
Plasmodium falciparum calcium-dependent protein kinase 5 0.009 0.0413 0.0597
Loa Loa (eye worm) hypothetical protein 0.0022 0.0031 0.0121
Brugia malayi major facilitator superfamily protein 0.0041 0.0139 0.0539
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Brugia malayi Cam kinase protein 1 0.009 0.0412 0.1595
Onchocerca volvulus Cathepsin L homolog 0.0028 0.0063 0.0199
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0025 0.005 0.0195
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0294 0.1557 0.1557
Plasmodium falciparum calcium-dependent protein kinase 1 0.009 0.0413 0.0597
Brugia malayi lysyl-tRNA synthetase 0.0066 0.0276 0.1065
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Schistosoma mansoni glucose transport protein 0.0294 0.1557 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0103 0.0484 0.9698
Toxoplasma gondii PHD-finger domain-containing protein 0.0051 0.0196 0.0429
Toxoplasma gondii facilitative glucose transporter GT1 0.0294 0.1557 0.3408
Onchocerca volvulus 0.0028 0.0063 0.0199
Schistosoma mansoni intermediate filament proteins 0.0048 0.0174 0.1119
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0093 0.1863
Plasmodium falciparum calcium-dependent protein kinase 4 0.009 0.0413 0.0597
Brugia malayi Papain family cysteine protease containing protein 0.0028 0.0063 0.0243
Giardia lamblia GTOR 0.008 0.0356 0.8852
Schistosoma mansoni Smad4 0.003 0.0075 0.048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0063 0.0402
Brugia malayi Calcitonin receptor-like protein seb-1 0.0218 0.1132 0.4376
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0041 0.0139 0.0894
Echinococcus multilocularis jumonji domain containing protein 0.0072 0.0309 0.0309
Brugia malayi PHD-finger family protein 0.0017 0.0002 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0241 0.1548
Plasmodium vivax CDK-related protein kinase 6, putative 0.1246 0.6908 1
Brugia malayi jmjC domain containing protein 0.0017 0.0001 0.0002
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0025 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0058 0.0371
Entamoeba histolytica hypothetical protein 0.0034 0.0098 0.2376
Schistosoma mansoni DNA polymerase eta 0.0048 0.0177 0.1135
Echinococcus multilocularis smad 0.003 0.0075 0.0075
Onchocerca volvulus 0.0041 0.0139 0.0497
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0017 0 0.0001
Trypanosoma cruzi hexose transporter, putative 0.005 0.0187 0.3743
Trypanosoma cruzi major cysteine proteinase, putative 0.0083 0.0373 0.7462
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0044
Plasmodium vivax glutathione reductase, putative 0.0039 0.0129 0.0186
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0027 0.0058 0.1156
Loa Loa (eye worm) fibroinase 0.0028 0.0063 0.0243
Brugia malayi Cathepsin L-like precursor 0.0028 0.0063 0.0243
Onchocerca volvulus Cathepsin F homolog 0.0028 0.0063 0.0199
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0177 0.3539
Loa Loa (eye worm) hypothetical protein 0.0218 0.1132 0.4376
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.0469 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0294 0.1557 0.1557
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0048 0.0177 0.1135
Schistosoma mansoni protein kinase 0.009 0.0412 0.2648
Trypanosoma brucei unspecified product 0.0048 0.0177 0.3539
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0023 0.0036 0.0036
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0129 0.0129
Brugia malayi major facilitator superfamily protein 0.0041 0.0139 0.0539
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0066 0.0276 0.1769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0058 0.0371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0058 0.0371
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.009 0.0413 0.0903
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Leishmania major DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Toxoplasma gondii thioredoxin reductase 0.0039 0.0129 0.0282
Echinococcus multilocularis General substrate transporter 0.0252 0.1325 0.1325
Trichomonas vaginalis CAMK family protein kinase 0.009 0.0412 0.2648
Echinococcus granulosus dna polymerase kappa 0.0048 0.0177 0.0177
Brugia malayi Smad1 0.003 0.0075 0.0289
Chlamydia trachomatis lysine--tRNA ligase 0.0066 0.0276 1
Schistosoma mansoni smad1 5 8 and 0.003 0.0075 0.048
Loa Loa (eye worm) major facilitator superfamily transporter 0.0041 0.0139 0.0539
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0063 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0419 0.269
Onchocerca volvulus 0.0048 0.0174 0.0633
Echinococcus multilocularis Smad4 0.003 0.0075 0.0075
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.009 0.0413 0.0597
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0103 0.0484 0.9698
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.008 0.0356 0.7131
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0168 0.0853 0.0852
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0241 0.1548
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0257 0.1648
Loa Loa (eye worm) hypothetical protein 0.0263 0.1385 0.5353
Onchocerca volvulus Cathepsin L homolog 0.0028 0.0063 0.0199
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0031 0.0082 0.2978
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.009 0.0412 0.1595
Brugia malayi Sugar transporter family protein 0.0041 0.0139 0.0539
Echinococcus multilocularis lamin dm0 0.0048 0.0174 0.0174
Brugia malayi Intermediate filament tail domain containing protein 0.0048 0.0174 0.0674
Loa Loa (eye worm) hypothetical protein 0.009 0.0412 0.1595
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0041 0.0139 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.008 0.0356 0.2286
Brugia malayi MH2 domain containing protein 0.003 0.0075 0.0289
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0063 0.0402
Toxoplasma gondii PHD-finger domain-containing protein 0.0017 0.0002 0.0003
Leishmania major cathepsin L-like protease 0.0105 0.0499 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0199 0.1275
Brugia malayi glycyl-tRNA synthetase 0.0017 0 0.0001
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.008 0.0356 0.7131
Trypanosoma cruzi cysteine peptidase, putative 0.0105 0.0499 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0257 0.0992
Echinococcus granulosus solute carrier family 22 0.0041 0.0139 0.0139
Entamoeba histolytica hypothetical protein 0.0034 0.0098 0.2376
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0002
Echinococcus granulosus dna polymerase eta 0.0048 0.0177 0.0177
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0294 0.1557 0.1557
Leishmania major hypothetical protein, conserved 0.0021 0.0025 0.0505
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Loa Loa (eye worm) jmjC domain-containing protein 0.0106 0.0503 0.1946
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0064 0.0265 0.5299
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.0469 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0051 0.0196 0.0196
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0088 0.0402 0.2583
Echinococcus multilocularis musashi 0.0048 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0088 0.0402 0.1555
Brugia malayi MH1 domain containing protein 0.003 0.0075 0.0289
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.008 0.0356 0.7131
Echinococcus granulosus solute carrier family 22 0.0041 0.0139 0.0139
Trypanosoma brucei glucose transporter, putative 0.0091 0.0419 0.839
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.014
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.0098 0.0629
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0041 0.0139 0.2788
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0027 0.0058 0.1156
Brugia malayi intermediate filament protein 0.0048 0.0174 0.0674
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0063 0.0402
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0066 0.0276 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0056 0.022 0.4692
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0011 0.0072
Brugia malayi Cathepsin L-like precursor 0.0028 0.0063 0.0243
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0243
Schistosoma mansoni hypothetical protein 0.0069 0.0295 0.1893
Schistosoma mansoni smad1 5 8 and 0.003 0.0075 0.048
Echinococcus multilocularis lysyl tRNA synthetase 0.0066 0.0276 0.0275
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0033 0.0094 0.1875
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0028 0.0063 0.0402
Loa Loa (eye worm) hypothetical protein 0.0051 0.0196 0.0758
Trypanosoma brucei glucose transporter, putative 0.0091 0.0419 0.839
Schistosoma mansoni protein kinase 0.009 0.0412 0.2648
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0048 0.0177 0.0683
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0499 1
Echinococcus multilocularis peregrin 0.0051 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0087 0.0395 0.1528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0208 0.1337
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0103 0.0484 0.9698
Brugia malayi hypothetical protein 0.0041 0.0139 0.0539
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0294 0.1557 0.1557
Giardia lamblia Prolyl-tRNA synthetase 0.0088 0.0402 1
Onchocerca volvulus 0.0028 0.0063 0.0199
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0001 0.0001
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Giardia lamblia DINP protein human, muc B family 0.0048 0.0177 0.4393
Schistosoma mansoni hypothetical protein 0.0034 0.0098 0.0629
Schistosoma mansoni hypothetical protein 0.0069 0.0295 0.1893
Plasmodium falciparum thioredoxin reductase 0.0039 0.0129 0.0186
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0048 0.0174 0.0674
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0063 0.0402
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0129 0.0498
Brugia malayi cathepsin L-like precursor 0.0019 0.0011 0.0044
Leishmania major protein kinase, putative 0.009 0.0412 0.826
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0001 0.0002
Echinococcus granulosus cathepsin l1 0.0028 0.0063 0.0063
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0017 0.0002 0.0004
Trypanosoma brucei THT1 - hexose transporter, putative 0.0091 0.0419 0.839
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0499 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0048 0.0177 0.3539
Loa Loa (eye worm) hypothetical protein 0.0069 0.0295 0.114
Brugia malayi hypothetical protein 0.0041 0.0139 0.0539
Schistosoma mansoni hypothetical protein 0.0149 0.0745 0.4782
Trypanosoma cruzi cysteine peptidase, putative 0.0105 0.0499 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0745 0.2878
Plasmodium falciparum protein kinase 6 0.1246 0.6908 1
Onchocerca volvulus Phospholipase A2 homolog 0.0477 0.2587 1
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0051 0.0196 0.1258
Brugia malayi PHD-finger family protein 0.0051 0.0196 0.0758
Echinococcus granulosus General substrate transporter 0.0252 0.1325 0.1325
Echinococcus granulosus jumonji domain containing protein 0.0072 0.0309 0.0309
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0075 0.0289
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0066 0.0276 1
Trypanosoma brucei unspecified product 0.0033 0.0093 0.1863
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0103 0.0484 0.9698
Loa Loa (eye worm) hypothetical protein 0.0017 0.0002 0.0007
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0257 0.0257
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0088 0.0402 0.2583
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0103 0.0484 0.9698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0063 0.0402
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0539
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0041 0.0139 0.0201
Giardia lamblia Hexose transporter 0.0041 0.0139 0.346
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0088 0.0402 0.1555
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Chlamydia trachomatis proline--tRNA ligase 0.0031 0.0082 0.2978
Echinococcus granulosus synaptic vesicle 2 protein 0.0041 0.0139 0.0139
Echinococcus multilocularis cysteine protease 0.0028 0.0063 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.0264 0.1697
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0499 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0309 0.1196
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.0412 0.8797
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0038 0.012 0.2392
Onchocerca volvulus 0.0041 0.0139 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0241 0.1548
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.008 0.0356 0.7131
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0001 0.0002
Toxoplasma gondii PHD-finger domain-containing protein 0.0051 0.0196 0.0429
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0027 0.0058 0.0058
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0063 0.1253
Echinococcus granulosus lamin 0.0048 0.0174 0.0174
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.0177 0.0683
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0048 0.0177 0.0177
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.009 0.0413 0.0597
Schistosoma mansoni thyroid hormone receptor 0.0111 0.0532 0.3419
Loa Loa (eye worm) hypothetical protein 0.0088 0.0402 0.1555
Mycobacterium ulcerans DNA polymerase IV 0.0048 0.0177 0.6414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0028 0.0177
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.0098 0.0098
Onchocerca volvulus 0.0041 0.0139 0.0497
Brugia malayi latrophilin 2 splice variant baaae 0.0149 0.0745 0.2878
Brugia malayi Phospholipase A2 family protein 0.0477 0.2587 1
Brugia malayi hypothetical protein 0.0021 0.0025 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0093 0.1863
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0241 0.1548
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0027 0.0058 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0002 0.0002
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0001 0.0002
Loa Loa (eye worm) sugar transporter 0.0294 0.1557 0.6019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0499 1
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0063 0.0402
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.009 0.0413 0.0903
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Loa Loa (eye worm) hypothetical protein 0.0048 0.0177 0.0683
Echinococcus granulosus Sugar transporter ERD6 protein 0.0041 0.0139 0.0139
Trypanosoma brucei glucose transporter 1E 0.0091 0.0419 0.839
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0025 0.0505
Brugia malayi jmjC domain containing protein 0.0017 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0044
Trypanosoma cruzi hexose transporter, putative 0.0091 0.0419 0.839
Echinococcus multilocularis cathepsin L cysteine protease 0.0028 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0294 0.1557 1
Schistosoma mansoni lamin 0.0048 0.0174 0.1119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0105 0.0499 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.015 0.096
Trypanosoma cruzi hexose transporter, putative 0.0091 0.0419 0.839
Onchocerca volvulus 0.0028 0.0063 0.0199
Schistosoma mansoni glucose transport protein 0.0294 0.1557 1
Brugia malayi jmjC domain containing protein 0.0062 0.0257 0.0992
Echinococcus granulosus solute carrier family 22 0.0041 0.0139 0.0139
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.009 0.0412 0.826
Trichomonas vaginalis sugar transporter, putative 0.0041 0.0139 0.0894

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 31.02 % Antagonist activity at human mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization at 1 uM by FDSS6000 assay ChEMBL. 23333207
Inhibition (binding) = 64.31 % Antagonist activity at human mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization at 10 uM by FDSS6000 assay ChEMBL. 23333207

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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