Detailed information for compound 1734993

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 398.329 | Formula: C14H28N2O7P2
  • H donors: 5 H acceptors: 7 LogP: -0.29 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCn1cc[n+](c1)CC(P(=O)(O)O)(P(=O)(O)[O-])O
  • InChi: 1S/C14H28N2O7P2/c1-2-3-4-5-6-7-8-9-15-10-11-16(13-15)12-14(17,24(18,19)20)25(21,22)23/h10-11,13,17H,2-9,12H2,1H3,(H3-,18,19,20,21,22,23)
  • InChiKey: ANVJZSKZYXLDSP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens farnesyl diphosphate synthase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Giardia lamblia Farnesyl diphosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Brugia malayi Polyprenyl synthetase family protein Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium knowlesi geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Babesia bovis farnesyl pyrophosphate synthetase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Cryptosporidium parvum putative farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Neospora caninum hypothetical protein Get druggable targets OG5_127590 All targets in OG5_127590
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium vivax geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium berghei geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma mansoni farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania major farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Plasmodium yoelii farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania donovani farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Loa Loa (eye worm) polyprenyl synthetase Get druggable targets OG5_127590 All targets in OG5_127590
Cryptosporidium hominis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Candida albicans similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase) Get druggable targets OG5_127590 All targets in OG5_127590
Candida albicans similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase) Get druggable targets OG5_127590 All targets in OG5_127590
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania mexicana farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Toxoplasma gondii polyprenyl synthetase superfamily protein Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus multilocularis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma congolense farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma cruzi farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania braziliensis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Theileria parva farnesyl pyrophosphate synthetase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma brucei farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus granulosus farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma japonicum ko:K00787 dimethylallyltranstransferase [EC2.5.1.1], putative Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania infantum farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0158298 0.0270728 0.0919316
Echinococcus granulosus biogenic amine 5HT receptor 0.0402596 0.0921019 0.0915024
Brugia malayi Sex muscle abnormal protein 5 0.0320626 0.0702825 0.0849662
Brugia malayi Protein kinase domain containing protein 0.0208755 0.0405037 0.0486247
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0323395 0.0710196 1
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.00865524 0.00797485 0.127281
Echinococcus multilocularis transfer RNA-Ala 0.0158298 0.0270728 0.0269465
Entamoeba histolytica hypothetical protein 0.0158298 0.0270728 0.0919316
Onchocerca volvulus 0.0208755 0.0405037 1
Schistosoma mansoni tensin 0.0162328 0.0281454 0.0287466
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.118761 0.301062 0.300601
Echinococcus granulosus epidermal growth factor receptor 0.0196009 0.0371109 0.0364751
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0953482 0.238741 0.238642
Trypanosoma brucei conserved protein 0.0158298 0.0270728 0.465984
Echinococcus multilocularis Spectrin alpha actinin 0.0158298 0.0270728 0.0269465
Brugia malayi protein-tyrosine kinase 0.0158298 0.0270728 0.0322338
Loa Loa (eye worm) IMP dehydrogenase 1 0.0059591 0.000798064 0.000138288
Entamoeba histolytica hypothetical protein 0.0158298 0.0270728 0.0919316
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0323395 0.0710196 0.070899
Loa Loa (eye worm) protein-tyrosine kinase 0.0158298 0.0270728 0.0264303
Schistosoma mansoni biogenic amine (5HT) receptor 0.0402596 0.0921019 0.0956376
Brugia malayi Variant SH3 domain containing protein 0.0320626 0.0702825 0.0849662
Loa Loa (eye worm) hypothetical protein 0.00865524 0.00797485 0.00731981
Echinococcus granulosus SH2 domain containing protein 7 0.0162328 0.0281454 0.0275036
Loa Loa (eye worm) carbonic anhydrase 3 0.0271417 0.0571835 0.0565609
Echinococcus granulosus insulin growth factor 1 receptor beta 0.00936452 0.00986288 0.00920909
Entamoeba histolytica hypothetical protein 0.0158298 0.0270728 0.0919316
Loa Loa (eye worm) TK/FER protein kinase 0.0208755 0.0405037 0.0398702
Trichomonas vaginalis p67phox protein, putative 0.0158298 0.0270728 1
Echinococcus multilocularis SH2 motif 0.0162328 0.0281454 0.0280192
Echinococcus granulosus NCK adaptor protein 0.0320626 0.0702825 0.0696686
Onchocerca volvulus 0.0158298 0.0270728 0.0769077
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0158298 0.0270728 0.0264303
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0271417 0.0571835 0.0689804
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.118761 0.301062 0.300972
Schistosoma mansoni carbonic anhydrase-related 0.0127498 0.0188741 0.01905
Brugia malayi Protein kinase domain containing protein 0.0154095 0.0259538 0.0308682
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0323395 0.0710196 0.0704062
Echinococcus multilocularis intersectin 2 0.0158298 0.0270728 0.0269465
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0158298 0.0270728 0.0276248
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0158298 0.0270728 0.0269465
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0123843 0.017901 0.303323
Schistosoma mansoni hypothetical protein 0.0127498 0.0188741 0.01905
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0158298 0.0270728 0.0276248
Echinococcus multilocularis tyrosine protein kinase Fyn 0.118761 0.301062 0.300972
Brugia malayi Protein kinase domain containing protein 0.0208755 0.0405037 0.0486247
Loa Loa (eye worm) hypothetical protein 0.00865524 0.00797485 0.00731981
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0162328 0.0281454 0.0280192
Trichomonas vaginalis conserved hypothetical protein 0.0158298 0.0270728 1
Trichomonas vaginalis conserved hypothetical protein 0.0158298 0.0270728 1
Brugia malayi Protein kinase domain containing protein 0.0208755 0.0405037 0.0486247
Echinococcus multilocularis nostrin 0.0158298 0.0270728 0.0269465
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0123843 0.017901 0.519753
Echinococcus granulosus expressed protein 0.0158298 0.0270728 0.0264303
Loa Loa (eye worm) TK/FER protein kinase 0.0208755 0.0405037 0.0398702
Brugia malayi Tensin 0.0162328 0.0281454 0.0335428
Echinococcus granulosus suppressor of cytokine signaling 7 0.0162328 0.0281454 0.0275036
Echinococcus multilocularis carbonic anhydrase 0.0127498 0.0188741 0.0187468
Echinococcus multilocularis tyrosine protein kinase Src64B 0.118761 0.301062 0.300972
Echinococcus multilocularis NCK adaptor protein 0.0320626 0.0702825 0.0701618
Echinococcus granulosus SH2 motif 0.0162328 0.0281454 0.0275036
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0059591 0.000798064 0.5
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0158298 0.0270728 0.0769077
Onchocerca volvulus 0.0162328 0.0281454 0.150625
Schistosoma mansoni apoptosis stimulating of P53 0.0158298 0.0270728 0.0276248
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0158298 0.0270728 0.0269465
Brugia malayi Guanylate kinase family protein 0.0158298 0.0270728 0.0322338
Echinococcus granulosus insulin receptor 0.00936452 0.00986288 0.00920909
Brugia malayi hypothetical protein 0.0208755 0.0405037 0.0486247
Schistosoma mansoni serine/threonine protein kinase 0.0204726 0.0394311 0.0405502
Brugia malayi Tyrosine-protein kinase abl-1 0.222636 0.577566 0.704045
Entamoeba histolytica hypothetical protein, conserved 0.0158298 0.0270728 0.0919316
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0162328 0.0281454 0.150625
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0123843 0.017901 0.519753
Echinococcus granulosus biogenic amine 5HT receptor 0.160458 0.412056 0.411668
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0323395 0.0710196 0.0704062
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0158298 0.0270728 0.0269465
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0367053 0.0826408 0.0825218
Schistosoma mansoni tyrosine kinase 0.00936452 0.00986288 0.00962527
Loa Loa (eye worm) TK/FER protein kinase 0.0208755 0.0405037 0.0398702
Echinococcus granulosus signal transduction protein lnk realted 0.0162328 0.0281454 0.0275036
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0154095 0.0259538 0.0253106
Echinococcus granulosus SH2 domain containing adapter protein F 0.0162328 0.0281454 0.0275036
Loa Loa (eye worm) hypothetical protein 0.0158298 0.0270728 0.0264303
Schistosoma mansoni hypothetical protein 0.0158298 0.0270728 0.0276248
Brugia malayi Fes/CIP4 homology domain containing protein 0.0158298 0.0270728 0.0322338
Entamoeba histolytica BAR/SH3 domain containing protein 0.0158298 0.0270728 0.0919316
Schistosoma mansoni SH2A 0.0162328 0.0281454 0.0287466
Onchocerca volvulus 0.0158298 0.0270728 0.0769077
Schistosoma mansoni sorting nexin 0.0158298 0.0270728 0.0276248
Brugia malayi cytokine inducible SH2-containing protein 5 0.0162328 0.0281454 0.0335428
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0123843 0.017901 1
Trichomonas vaginalis conserved hypothetical protein 0.0158298 0.0270728 1
Onchocerca volvulus 0.0208755 0.0405037 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0284032 0.0605416 0.0599212
Echinococcus multilocularis insulin receptor 0.00936452 0.00986288 0.00973436
Echinococcus multilocularis tyrosine protein kinase Srms 0.102931 0.258925 0.258829
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0162328 0.0281454 0.0287466
Echinococcus multilocularis tyrosine protein kinase shark 0.0208755 0.0405037 0.0403792
Loa Loa (eye worm) hypothetical protein 0.0320626 0.0702825 0.0696686
Brugia malayi SH2 domain containing protein 0.0162328 0.0281454 0.0335428
Loa Loa (eye worm) guanylate kinase 0.0158298 0.0270728 0.0264303
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0158298 0.0270728 0.0264303
Loa Loa (eye worm) SH2 domain-containing protein 0.0162328 0.0281454 0.0275036
Echinococcus multilocularis epidermal growth factor receptor 0.0196009 0.0371109 0.0369859
Loa Loa (eye worm) hypothetical protein 0.0208755 0.0405037 0.0398702
Echinococcus granulosus tyrosine protein kinase Fyn 0.118761 0.301062 0.300601
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0367053 0.0826408 0.0857425
Onchocerca volvulus 0.0208755 0.0405037 1
Loa Loa (eye worm) hypothetical protein 0.0162328 0.0281454 0.0275036
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0154095 0.0259538 0.0253106
Schistosoma mansoni tyrosine kinase 0.0208755 0.0405037 0.041672
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.00865524 0.00797485 0.00892706
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0158298 0.0270728 0.0276248
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0271417 0.0571835 0.0591171
Echinococcus granulosus epidermal growth factor receptor 0.0126402 0.0185823 0.0179342
Brugia malayi Myosin tail family protein 0.0158298 0.0270728 0.0322338
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0284032 0.0605416 0.0730785
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0158298 0.0270728 0.0264303
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0127498 0.0188741 0.0182263
Brugia malayi tRNA modification GTPase TrmE family protein 0.0162328 0.0281454 0.0335428
Schistosoma mansoni tyrosine kinase 0.00799745 0.0062239 0.00581932
Schistosoma mansoni tyrosine kinase 0.0208755 0.0405037 0.041672
Loa Loa (eye worm) SH2 domain-containing protein 0.0162328 0.0281454 0.0275036
Onchocerca volvulus 0.0162328 0.0281454 0.150625
Entamoeba histolytica protein kinase, putative 0.0162791 0.0282685 0.0976877
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.00865524 0.00797485 0.127281
Loa Loa (eye worm) hypothetical protein 0.0162328 0.0281454 0.0275036
Brugia malayi hypothetical protein 0.0162328 0.0281454 0.0335428
Brugia malayi Sphingomyelin synthase-related 1 0.00865524 0.00797485 0.00892706
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0320626 0.0702825 0.0728171
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0323395 0.0710196 0.070899
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0127498 0.0188741 0.0222284
Echinococcus granulosus SHC transforming protein 3 0.0162328 0.0281454 0.0275036
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0123843 0.017901 1
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0059591 0.000798064 0.000138288
Schistosoma mansoni formin binding protein and related proteins 0.0158298 0.0270728 0.0276248
Schistosoma mansoni tyrosine kinase 0.00936452 0.00986288 0.00962527
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.102931 0.258925 0.258436
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.118761 0.301062 0.300601
Echinococcus multilocularis carbonic anhydrase II 0.0271417 0.0571835 0.0570611
Schistosoma mansoni GTPase activating protein 0.0162328 0.0281454 0.0287466
Echinococcus granulosus expressed conserved protein 0.0162328 0.0281454 0.0275036
Echinococcus multilocularis carbonic anhydrase 0.0127498 0.0188741 0.0187468
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0271417 0.0571835 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0162328 0.0281454 0.0287466
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0158298 0.0270728 1
Loa Loa (eye worm) hypothetical protein 0.313741 0.820076 0.819957
Entamoeba histolytica hypothetical protein 0.0158298 0.0270728 0.0919316
Echinococcus granulosus sphingomyelin synthase protein 1 0.00865524 0.00797485 0.00731981
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0123843 0.017901 0.303323
Echinococcus granulosus tyrosine protein kinase Srms 0.0208755 0.0405037 0.0398702
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0162328 0.0281454 0.0280192
Schistosoma mansoni suppressor of cytokine signaling 0.0162328 0.0281454 0.0287466
Plasmodium falciparum sphingomyelin synthase 1, putative 0.00865524 0.00797485 0.422528
Echinococcus granulosus growth factor receptor bound protein 2 0.0320626 0.0702825 0.0696686
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0158298 0.0270728 0.0276248
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0127498 0.0188741 0.0222284
Loa Loa (eye worm) hypothetical protein 0.0162328 0.0281454 0.0275036
Echinococcus granulosus nostrin 0.0158298 0.0270728 0.0264303
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0208755 0.0405037 0.0403792
Schistosoma mansoni serine/threonine protein kinase 0.0154095 0.0259538 0.0264545
Echinococcus multilocularis tyrosine protein kinase Fyn 0.118761 0.301062 0.300972
Schistosoma mansoni C-fyn 0.0158298 0.0270728 0.0276248
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0162328 0.0281454 0.0280192
Echinococcus multilocularis growth factor receptor bound protein 2 0.0320626 0.0702825 0.0701618
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0284032 0.0605416 0.0599212
Schistosoma mansoni dynamin-associated protein 0.0158298 0.0270728 0.0276248
Loa Loa (eye worm) SH2 domain-containing protein 0.0162328 0.0281454 0.0275036
Brugia malayi Variant SH3 domain containing protein 0.0158298 0.0270728 0.0322338
Echinococcus granulosus src region 0.0158298 0.0270728 0.0264303
Brugia malayi Variant SH3 domain containing protein 0.0158298 0.0270728 0.0322338
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0162328 0.0281454 0.0335428
Schistosoma mansoni tyrosine kinase 0.118761 0.301062 0.314186
Loa Loa (eye worm) thyroid receptor interactor 0.0158298 0.0270728 0.0264303
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0162328 0.0281454 0.0280192
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0208755 0.0405037 0.0398702
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0162328 0.0281454 0.150625
Onchocerca volvulus 0.0208755 0.0405037 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.118761 0.301062 0.300601
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0323395 0.0710196 0.073588
Schistosoma mansoni tyrosine kinase 0.0126402 0.0185823 0.0187447
Loa Loa (eye worm) hypothetical protein 0.0162328 0.0281454 0.0275036
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.00865524 0.00797485 0.127281
Brugia malayi Protein kinase domain containing protein 0.0208755 0.0405037 0.0486247
Loa Loa (eye worm) hypothetical protein 0.0158298 0.0270728 0.0264303
Brugia malayi Variant SH3 domain containing protein 0.0158298 0.0270728 0.0322338
Brugia malayi Variant SH3 domain containing protein 0.0158298 0.0270728 0.0322338
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0158298 0.0270728 0.0269465
Entamoeba histolytica hypothetical protein 0.0158298 0.0270728 0.0919316
Echinococcus granulosus c src tyrosine kinase 0.0367053 0.0826408 0.0820351
Brugia malayi RhoGAP domain containing protein 0.0162328 0.0281454 0.0335428
Echinococcus granulosus carbonic anhydrase 0.0127498 0.0188741 0.0182263
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0158298 0.0270728 0.0264303
Brugia malayi Furin-like cysteine rich region family protein 0.0196009 0.0371109 0.0444842
Echinococcus granulosus SH2 motif 0.0162328 0.0281454 0.0275036
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0162328 0.0281454 0.0275036
Brugia malayi Protein kinase domain containing protein 0.00936452 0.00986288 0.0112312
Echinococcus granulosus N chimaerin 0.0162328 0.0281454 0.0275036
Loa Loa (eye worm) hypothetical protein 0.0402596 0.0921019 0.0915024
Loa Loa (eye worm) hypothetical protein 0.0323395 0.0710196 0.0704062
Entamoeba histolytica protein kinase, putative 0.0866981 0.215715 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0162328 0.0281454 0.0275036
Schistosoma mansoni tyrosine kinase 0.365101 0.95679 1
Brugia malayi SRC-1 0.118761 0.301062 0.366606
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0126402 0.0185823 0.0179342
Echinococcus multilocularis tyrosine protein kinase HCK 0.0866981 0.215715 0.215614
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0158298 0.0270728 0.0264303
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0127498 0.0188741 0.0222284
Schistosoma mansoni tensin-related 0.0162328 0.0281454 0.0287466
Trypanosoma cruzi hypothetical protein, conserved 0.0158298 0.0270728 0.465984
Brugia malayi Variant SH3 domain containing protein 0.0162328 0.0281454 0.0335428
Echinococcus multilocularis c src tyrosine kinase 0.0367053 0.0826408 0.0825218
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0123843 0.017901 0.519753
Schistosoma mansoni tyrosine kinase 0.0367053 0.0826408 0.0857425
Leishmania major carbonic anhydrase-like protein 0.0271417 0.0571835 1
Loa Loa (eye worm) hypothetical protein 0.0158298 0.0270728 0.0264303
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0123843 0.017901 0.0172526
Brugia malayi Spectrin alpha chain 0.0158298 0.0270728 0.0322338
Echinococcus granulosus tyrosine protein kinase Fyn 0.118761 0.301062 0.300601
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0162328 0.0281454 0.0275036
Loa Loa (eye worm) hypothetical protein 0.0162328 0.0281454 0.0275036
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0154095 0.0259538 0.0253106
Echinococcus granulosus carbonic anhydrase 0.0127498 0.0188741 0.0182263
Schistosoma mansoni tyrosine kinase 0.00799745 0.0062239 0.00581932
Echinococcus multilocularis tyrosine protein kinase Src42A 0.118761 0.301062 0.300972
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.313741 0.820076 1
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.00865524 0.00797485 0.127281
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0123843 0.017901 0.303323
Onchocerca volvulus 0.0158298 0.0270728 0.0769077
Loa Loa (eye worm) hypothetical protein 0.0158298 0.0270728 0.0264303
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0123843 0.017901 1
Loa Loa (eye worm) hypothetical protein 0.00865524 0.00797485 0.00731981
Trypanosoma brucei inositol phosphorylceramide synthase 0.00865524 0.00797485 0.127281
Schistosoma mansoni sorbin 0.0158298 0.0270728 0.0276248
Schistosoma mansoni Dab2-interacting protein-like 0.0158298 0.0270728 0.0276248
Loa Loa (eye worm) polyprenyl synthetase 0.0123843 0.017901 0.0172526
Echinococcus granulosus tyrosine protein kinase HCK 0.0866981 0.215715 0.215198
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0162328 0.0281454 0.0287466
Loa Loa (eye worm) hypothetical protein 0.0162328 0.0281454 0.0275036
Loa Loa (eye worm) hypothetical protein 0.0127498 0.0188741 0.0182263
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.00865524 0.00797485 0.00892706
Loa Loa (eye worm) TK/EGFR protein kinase 0.0196009 0.0371109 0.0364751
Entamoeba histolytica SH2 domain containing protein 0.0162328 0.0281454 0.0970947
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0158298 0.0270728 0.0264303
Echinococcus multilocularis tyrosine protein kinase Blk 0.102931 0.258925 0.258829
Brugia malayi SH2 domain containing protein 0.0162328 0.0281454 0.0335428
Echinococcus multilocularis tyrosine kinase 0.0208755 0.0405037 0.0403792
Loa Loa (eye worm) hypothetical protein 0.0162328 0.0281454 0.0275036
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.118761 0.301062 0.300972
Trichomonas vaginalis conserved hypothetical protein 0.0158298 0.0270728 1
Brugia malayi SH2 domain containing protein 0.0162328 0.0281454 0.0335428
Brugia malayi SH2 domain containing protein 0.0162328 0.0281454 0.0335428
Loa Loa (eye worm) TK/FER protein kinase 0.0208755 0.0405037 0.0398702
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0208755 0.0405037 0.156584
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0162328 0.0281454 0.0275036
Plasmodium falciparum sphingomyelin synthase 1, putative 0.00865524 0.00797485 0.422528
Trichomonas vaginalis conserved hypothetical protein 0.0158298 0.0270728 1
Loa Loa (eye worm) SRC-1 0.118761 0.301062 0.300601
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0162328 0.0281454 0.0275036
Loa Loa (eye worm) p53BP2 0.0158298 0.0270728 0.0264303
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0154095 0.0259538 0.0258273
Echinococcus multilocularis SH2 motif 0.0162328 0.0281454 0.0280192
Echinococcus multilocularis tensin 0.0162328 0.0281454 0.0280192
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0127498 0.0188741 0.0222284
Onchocerca volvulus 0.0158761 0.027196 0.085375
Echinococcus multilocularis tensin 0.0162328 0.0281454 0.0280192
Echinococcus multilocularis serotonin receptor 0.0402596 0.0921019 0.091984
Trichomonas vaginalis conserved hypothetical protein 0.0158298 0.0270728 1
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0059591 0.000798064 0.000668361
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0162328 0.0281454 0.0280192
Brugia malayi Polyprenyl synthetase family protein 0.0123843 0.017901 0.0210408
Echinococcus granulosus tyrosine kinase 0.102931 0.258925 0.258436
Schistosoma mansoni tensin 0.0162328 0.0281454 0.0287466
Entamoeba histolytica hypothetical protein 0.0158298 0.0270728 0.0919316
Trypanosoma brucei carbonic anhydrase-like protein 0.0271417 0.0571835 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.102931 0.258925 0.258829
Schistosoma mansoni carbonic anhydrase 0.0127498 0.0188741 0.01905
Loa Loa (eye worm) TK/FER protein kinase 0.0208755 0.0405037 0.0398702
Echinococcus multilocularis sphingomyelin synthase protein 1 0.00865524 0.00797485 0.00784607
Schistosoma mansoni tyrosine kinase 0.0367053 0.0826408 0.0857425
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0271417 0.0571835 0.0591171
Schistosoma mansoni nck2/grb4 0.0320626 0.0702825 0.0728171
Plasmodium falciparum carbonic anhydrase 0.0127498 0.0188741 1
Schistosoma mansoni tyrosine kinase 0.118761 0.301062 0.314186
Echinococcus granulosus fch and double sh3 domains protein 2 0.0158298 0.0270728 0.0264303
Schistosoma mansoni biogenic amine (5HT) receptor 0.160458 0.412056 0.430272
Loa Loa (eye worm) hypothetical protein 0.0158298 0.0270728 0.0264303
Onchocerca volvulus 0.0162328 0.0281454 0.150625
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0162328 0.0281454 0.0275036
Loa Loa (eye worm) hypothetical protein 0.0162328 0.0281454 0.0275036
Schistosoma mansoni carbonic anhydrase-related 0.0127498 0.0188741 0.01905
Loa Loa (eye worm) TK/FER protein kinase 0.0208755 0.0405037 0.0398702
Schistosoma mansoni eps8-related protein 0.0158298 0.0270728 0.0276248
Onchocerca volvulus 0.0162328 0.0281454 0.150625
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0982881 0.246567 0.246469
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.00865524 0.00797485 0.00892706
Echinococcus granulosus tyrosine protein kinase shark 0.0208755 0.0405037 0.0398702
Loa Loa (eye worm) hypothetical protein 0.00865524 0.00797485 0.00731981
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0320626 0.0702825 0.0696686
Loa Loa (eye worm) hypothetical protein 0.0162328 0.0281454 0.0275036
Schistosoma mansoni shc transforming protein 0.0162328 0.0281454 0.0287466
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.00936452 0.00986288 0.00973436
Echinococcus multilocularis tyrosine protein kinase Abl 0.174528 0.449507 0.449436
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0154095 0.0259538 0.0308682
Onchocerca volvulus 0.0162328 0.0281454 0.150625
Schistosoma mansoni tensin 0.0162328 0.0281454 0.0287466
Echinococcus multilocularis carbonic anhydrase 0.0127498 0.0188741 0.0187468
Echinococcus granulosus hypothetical protein 0.0162328 0.0281454 0.0275036
Schistosoma mansoni dreadlocks/dock 0.0158298 0.0270728 0.0276248
Echinococcus granulosus suppressor of cytokine signaling 6 0.0162328 0.0281454 0.0275036
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0158298 0.0270728 0.0269465
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0059591 0.000798064 0.000168653
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0158298 0.0270728 0.0264303
Echinococcus multilocularis tyrosine protein kinase ABL1 0.381334 1 1
Loa Loa (eye worm) hypothetical protein 0.0162328 0.0281454 0.0275036
Loa Loa (eye worm) hypothetical protein 0.0158298 0.0270728 0.0264303
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0162328 0.0281454 0.0280192
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0162328 0.0281454 0.0287466
Loa Loa (eye worm) hypothetical protein 0.0402596 0.0921019 0.0915024
Echinococcus granulosus Spectrin alpha actinin 0.0158298 0.0270728 0.0264303
Loa Loa (eye worm) hypothetical protein 0.0162328 0.0281454 0.0275036
Schistosoma mansoni growth factor receptor-bound protein 0.0320626 0.0702825 0.0728171
Loa Loa (eye worm) hypothetical protein 0.142465 0.36416 0.36374
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0271417 0.0571835 1
Schistosoma mansoni hypothetical protein 0.0158298 0.0270728 0.0276248
Loa Loa (eye worm) hypothetical protein 0.0162328 0.0281454 0.0275036
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0162328 0.0281454 0.0275036
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0123843 0.017901 0.0180323
Echinococcus granulosus carbonic anhydrase 0.0127498 0.0188741 0.0182263
Schistosoma mansoni spingomyelin synthetase-related 0.00865524 0.00797485 0.00765061
Schistosoma mansoni tyrosine kinase 0.0126402 0.0185823 0.0187447
Loa Loa (eye worm) TK/INSR protein kinase 0.00936452 0.00986288 0.00920909
Schistosoma mansoni suppressor of cytokine signaling 0.0162328 0.0281454 0.0287466
Echinococcus multilocularis epidermal growth factor receptor 0.0126402 0.0185823 0.0184549
Echinococcus multilocularis expressed protein 0.0158298 0.0270728 0.0269465
Echinococcus multilocularis SH2 motif 0.0162328 0.0281454 0.0280192
Echinococcus multilocularis tyrosine protein kinase Fyn 0.118761 0.301062 0.300972
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0162328 0.0281454 0.0275036
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.118761 0.301062 0.300972
Echinococcus multilocularis 0.0162328 0.0281454 0.0280192
Toxoplasma gondii hypothetical protein 0.0127498 0.0188741 0.255238
Loa Loa (eye worm) hypothetical protein 0.00865524 0.00797485 0.00731981
Schistosoma mansoni growth factor receptor-bound protein 0.0320626 0.0702825 0.0728171
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0123843 0.017901 1
Brugia malayi SH3 domain containing protein 0.0158298 0.0270728 0.0322338
Loa Loa (eye worm) TK protein kinase 0.102931 0.258925 0.258436
Onchocerca volvulus 0.0208755 0.0405037 1
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0123843 0.017901 0.0177736
Echinococcus multilocularis N chimaerin 0.0162328 0.0281454 0.0280192
Schistosoma mansoni carbonic anhydrase-related 0.0127498 0.0188741 0.01905
Echinococcus multilocularis signal transduction protein lnk realted 0.0162328 0.0281454 0.0280192
Schistosoma mansoni vav2 0.0162328 0.0281454 0.0287466
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0059591 0.000798064 0.000144537
Trichomonas vaginalis conserved hypothetical protein 0.0158298 0.0270728 1
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0123843 0.017901 0.241498
Leishmania major farnesyl pyrophosphate synthase 0.0123843 0.017901 0.303323
Onchocerca volvulus Putative cortactin 0.0158298 0.0270728 0.0769077
Echinococcus granulosus tyrosine protein kinase Src42A 0.0982881 0.246567 0.246069
Echinococcus granulosus tyrosine protein kinase Src64B 0.118761 0.301062 0.300601
Schistosoma mansoni adapter molecule crk 0.0320626 0.0702825 0.0728171
Echinococcus multilocularis SH2 domain containing protein 7 0.0162328 0.0281454 0.0280192
Plasmodium vivax sphingomyelin synthase 1, putative 0.00865524 0.00797485 0.445496
Brugia malayi SH2 domain containing protein 0.0162328 0.0281454 0.0335428
Loa Loa (eye worm) hypothetical protein 0.0127498 0.0188741 0.0182263
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0162328 0.0281454 0.0280192
Echinococcus granulosus tyrosine protein kinase Lyn 0.118807 0.301185 0.300724
Entamoeba histolytica hypothetical protein, conserved 0.0158298 0.0270728 0.0919316
Entamoeba histolytica protein kinase, putative 0.0158298 0.0270728 0.0919316
Loa Loa (eye worm) STAT protein 0.0162328 0.0281454 0.0275036
Echinococcus granulosus tm gpcr rhodopsin 0.0953482 0.238741 0.238238
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0271417 0.0571835 0.0565609
Brugia malayi Variant SH3 domain containing protein 0.0158298 0.0270728 0.0322338
Loa Loa (eye worm) TK/FER protein kinase 0.0208755 0.0405037 0.0398702
Brugia malayi Src substrate cortactin 0.0158298 0.0270728 0.0322338
Echinococcus multilocularis tyrosine protein kinase Fgr 0.118761 0.301062 0.300972
Schistosoma mansoni hypothetical protein 0.0162328 0.0281454 0.0287466
Plasmodium vivax sphingomyelin synthase 2, putative 0.00865524 0.00797485 0.445496
Brugia malayi SH2 domain containing protein 0.0208755 0.0405037 0.0486247
Schistosoma mansoni tyrosine kinase 0.0196009 0.0371109 0.0381235
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0162791 0.0282685 0.0976877
Loa Loa (eye worm) TK/FER protein kinase 0.0208755 0.0405037 0.0398702
Echinococcus granulosus tyrosine protein kinase ABL1 0.381334 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0208755 0.0405037 0.0398702
Brugia malayi SH2 domain containing protein 0.0162328 0.0281454 0.0335428
Onchocerca volvulus 0.0208755 0.0405037 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0284032 0.0605416 0.0604196
Brugia malayi Variant SH3 domain containing protein 0.0158298 0.0270728 0.0322338
Echinococcus multilocularis SHC transforming protein 3 0.0162328 0.0281454 0.0280192
Schistosoma mansoni run and tbc1 domain containing 0.0158298 0.0270728 0.0276248
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0320626 0.0702825 0.0696686
Trypanosoma cruzi hypothetical protein, conserved 0.0158298 0.0270728 0.465984
Entamoeba histolytica unconventional myosin IB 0.0158298 0.0270728 0.0919316
Loa Loa (eye worm) TK/FER protein kinase 0.0208755 0.0405037 0.0398702
Echinococcus granulosus epidermal growth factor receptor kinase 0.0158298 0.0270728 0.0264303
Brugia malayi Peripheral plasma membrane protein CASK 0.0158298 0.0270728 0.0322338
Schistosoma mansoni tensin-related 0.0162328 0.0281454 0.0287466
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0158298 0.0270728 0.0269465
Echinococcus multilocularis potassium voltage gated channel protein 0.00590719 0.000659867 0.000530147
Schistosoma mansoni tyrosine kinase 0.00799745 0.0062239 0.00581932
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0158298 0.0270728 0.465984
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0162328 0.0281454 0.0275036
Leishmania major hypothetical protein, conserved 0.0158298 0.0270728 0.465984
Echinococcus granulosus tyrosine protein kinase Fyn 0.118761 0.301062 0.300601
Loa Loa (eye worm) TK protein kinase 0.0866981 0.215715 0.215198
Echinococcus granulosus tyrosine kinase 0.0208755 0.0405037 0.0398702
Entamoeba histolytica BAR/SH3 domain containing protein 0.0158298 0.0270728 0.0919316
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0059591 0.000798064 0.0445819
Loa Loa (eye worm) hypothetical protein 0.0127498 0.0188741 0.0182263
Entamoeba histolytica hypothetical protein 0.0158298 0.0270728 0.0919316
Echinococcus granulosus intersectin 2 0.0158298 0.0270728 0.0264303
Echinococcus granulosus carbonic anhydrase II 0.0271417 0.0571835 0.0565609
Loa Loa (eye worm) hypothetical protein 0.0158298 0.0270728 0.0264303
Onchocerca volvulus 0.0162328 0.0281454 0.150625
Onchocerca volvulus 0.0158298 0.0270728 0.0769077
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0127498 0.0188741 0.0222284
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.00865524 0.00797485 0.00892706
Brugia malayi Variant SH3 domain containing protein 0.0320626 0.0702825 0.0849662
Trypanosoma cruzi hypothetical protein, conserved 0.0158298 0.0270728 0.465984
Echinococcus multilocularis endophilin A3 0.0158298 0.0270728 0.0269465
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.00865524 0.00797485 0.127281
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.00865524 0.00797485 0.127281
Loa Loa (eye worm) hypothetical protein 0.0158298 0.0270728 0.0264303
Brugia malayi STAT protein, DNA binding domain containing protein 0.0162328 0.0281454 0.0335428
Loa Loa (eye worm) hypothetical protein 0.0162328 0.0281454 0.0275036
Echinococcus multilocularis biogenic amine (5HT) receptor 0.160458 0.412056 0.41198
Schistosoma mansoni signal transduction protein lnk-related 0.0162328 0.0281454 0.0287466
Loa Loa (eye worm) hypothetical protein 0.0162328 0.0281454 0.0275036
Echinococcus granulosus endophilin A3 0.0158298 0.0270728 0.0264303
Brugia malayi SH2 domain containing protein 0.0162328 0.0281454 0.0335428
Loa Loa (eye worm) hypothetical protein 0.0158298 0.0270728 0.0264303
Toxoplasma gondii hypothetical protein 0.00865524 0.00797485 0.101338
Echinococcus multilocularis serotonin receptor 0.0402596 0.0921019 0.091984
Echinococcus granulosus tensin 0.0162328 0.0281454 0.0275036
Brugia malayi protein-tyrosine kinase 0.102931 0.258925 0.315182
Plasmodium falciparum sphingomyelin synthase 2, putative 0.00865524 0.00797485 0.422528
Echinococcus granulosus tyrosine protein kinase Blk 0.102931 0.258925 0.258436
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0271417 0.0571835 0.0689804
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0162328 0.0281454 0.0280192
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0158298 0.0270728 0.0269465
Brugia malayi Variant SH3 domain containing protein 0.0162328 0.0281454 0.0335428
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0123843 0.017901 0.948443
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0325645 0.0716184 1
Brugia malayi Protein kinase domain containing protein 0.0208755 0.0405037 0.0486247
Brugia malayi SH2 domain containing protein 0.0208755 0.0405037 0.0486247
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0059591 0.000798064 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0367053 0.0826408 0.0820351
Brugia malayi Tyrosine-protein kinase abl-1 0.174528 0.449507 0.547765
Schistosoma mansoni hypothetical protein 0.0162328 0.0281454 0.0287466
Schistosoma mansoni cell polarity protein 0.0158298 0.0270728 0.0276248
Loa Loa (eye worm) TK/ABL protein kinase 0.381334 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.08 uM Inhibition of His6-tagged human truncated FPPS (6-353) expressed in Escherichia coli BL21(DE3) cells using geranyl diphosphate and isopentenyl diphosphate as substrate preincubated with enzyme for 30 mins by spectrophotometric analysis ChEMBL. 23610597
IC50 (binding) = 0.12 uM Binding affinity to human FPPS at 1 mM by X-ray crystallographic analysis ChEMBL. 23610597
IC50 (functional) = 5.9 uM Inhibition of Plasmodium falciparum growth after 72 hrs by LDH assay ChEMBL. 23610597

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 23610597

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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