Detailed information for compound 173878

Basic information

Technical information
  • TDR Targets ID: 173878
  • Name: (1S)-2-(tert-butylamino)-1-[7-[(1S)-1-hydroxy ethyl]-1-benzofuran-2-yl]ethanol
  • MW: 277.359 | Formula: C16H23NO3
  • H donors: 3 H acceptors: 2 LogP: 1.58 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](c1cc2c(o1)c(ccc2)[C@@H](O)C)CNC(C)(C)C
  • InChi: 1S/C16H23NO3/c1-10(18)12-7-5-6-11-8-14(20-15(11)12)13(19)9-17-16(2,3)4/h5-8,10,13,17-19H,9H2,1-4H3/t10-,13-/m0/s1
  • InChiKey: GTYMTYBCXVOBBB-GWCFXTLKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1S)-2-(tert-butylamino)-1-[7-[(1S)-1-hydroxyethyl]benzofuran-2-yl]ethanol
  • (1S)-2-(tert-butylamino)-1-[7-[(1S)-1-hydroxyethyl]-2-benzofuranyl]ethanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0386 0.4065 0.5531
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0118 0.1153 0.1164
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0295 0.0835
Echinococcus granulosus unc 13 munc13 0.0034 0.025 0.0253
Echinococcus granulosus Nuclear hormone receptor HR96 0.0182 0.1852 0.1871
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0344 0.0423
Schistosoma mansoni biogenic amine (5HT) receptor 0.0065 0.058 0.0784
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0862 0.0955
Brugia malayi Protein kinase domain containing protein 0.0042 0.0336 0.0353
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0089 0.013
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0336 0.0451
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0266 0.0357
Brugia malayi jmjC domain containing protein 0.0164 0.1654 0.186
Echinococcus granulosus raf serine:threonine protein kinase 0.0031 0.0217 0.022
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0077 0.0152
Schistosoma mansoni rac gtpase activating protein 0.003 0.0201 0.0268
Loa Loa (eye worm) hypothetical protein 0.0028 0.0177 0.0142
Onchocerca volvulus 0.0182 0.1852 0.1852
Schistosoma mansoni peptidase Clp (S14 family) 0.0158 0.1592 0.2163
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0289 0.0299
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0386 0.4065 0.4106
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0204 0.2089 0.284
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0182 0.1852 0.1871
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0182 0.1852 0.1871
Echinococcus granulosus protein kinase C gamma type 0.0119 0.117 0.1182
Brugia malayi Hr1 repeat family protein 0.0042 0.0336 0.0353
Schistosoma mansoni unc-13 (munc13) 0.0037 0.0274 0.0368
Loa Loa (eye worm) hypothetical protein 0.0386 0.4065 0.4601
Brugia malayi RhoGEF domain containing protein 0.003 0.0201 0.0199
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0109 0.1064 0.1444
Loa Loa (eye worm) hypothetical protein 0.0109 0.1064 0.1159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0662 0.0699
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0053 0.0053
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0193 0.0905
Onchocerca volvulus 0.0016 0.0053 0.0053
Mycobacterium ulcerans hypothetical protein 0.0028 0.0177 0.0508
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.2458 0.2483
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0177 0.249
Echinococcus multilocularis cysteine protease 0.0016 0.0053 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0175 0.0123
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0101 0.0262
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.017
Echinococcus granulosus Protein kinase C brain isozyme 0.0149 0.1494 0.1509
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0386 0.4065 0.4601
Entamoeba histolytica hypothetical protein 0.0036 0.0266 0.2841
Echinococcus granulosus Diacylglycerol kinase theta 0.003 0.0201 0.0203
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0004 0.0005
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0339 0.0343
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.1494 0.203
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0158 0.1592 1
Onchocerca volvulus 0.0386 0.4065 0.4065
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0386 0.4065 0.5531
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0077 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0386 0.4065 0.4618
Echinococcus granulosus peptidase Clp S14 family 0.0104 0.1001 0.1011
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0158 0.1592 1
Schistosoma mansoni retinoic acid receptor RXR 0.0386 0.4065 0.5531
Echinococcus granulosus geminin 0.0508 0.5391 0.5445
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0154 0.0156
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0158 0.1592 0.1608
Loa Loa (eye worm) hypothetical protein 0.0182 0.1852 0.2064
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0386 0.4065 0.4618
Onchocerca volvulus 0.0016 0.0053 0.0053
Brugia malayi Protein kinase domain containing protein 0.0031 0.0211 0.0211
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0386 0.4065 0.5531
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0344 0.5865
Loa Loa (eye worm) hypothetical protein 0.0102 0.0987 0.1071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0862 0.1168
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0217 0.029
Entamoeba histolytica diacylglycerol kinase, putative 0.003 0.0201 0.1975
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0077 0.0098
Brugia malayi hypothetical protein 0.0182 0.1852 0.2088
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.003 0.0201 0.0203
Brugia malayi protein kinase C II. 0.0161 0.1625 0.1828
Brugia malayi ecdysone receptor 0.0182 0.1852 0.2088
Echinococcus multilocularis neuropeptide receptor A26 0.0923 0.99 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0298 0.0298
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0177 0.0179
Loa Loa (eye worm) hypothetical protein 0.0065 0.058 0.0604
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0182 0.1852 0.1871
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0336 0.0284
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0158 0.1592 0.1608
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0031 0.0211 0.0213
Brugia malayi isocitrate dehydrogenase 0.0018 0.0077 0.0057
Onchocerca volvulus 0.0053 0.0452 0.0452
Entamoeba histolytica hypothetical protein 0.0036 0.0266 0.2841
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0055
Loa Loa (eye worm) hypothetical protein 0.0182 0.1852 0.2064
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0386 0.4065 0.4106
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0177 0.0179
Echinococcus multilocularis RNA directed DNA polymerase 0.0072 0.0662 0.0669
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0161 0.0701
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0158 0.1592 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0177 0.0179
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0295 0.236
Echinococcus multilocularis serine:threonine protein kinase N2 0.0042 0.0336 0.0339
Loa Loa (eye worm) hypothetical protein 0.0182 0.1852 0.2064
Loa Loa (eye worm) hypothetical protein 0.0127 0.1252 0.1375
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0862 0.087
Loa Loa (eye worm) hypothetical protein 0.0386 0.4065 0.4601
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.017
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0386 0.4065 0.4106
Schistosoma mansoni nuclear hormone receptor 0.0182 0.1852 0.2518
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0386 0.4065 0.4618
Echinococcus multilocularis serine threonine protein kinase 0.0119 0.117 0.1182
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0077 0.0472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0862 0.1168
Schistosoma mansoni vav2 0.003 0.0201 0.0268
Echinococcus multilocularis raf serine:threonine protein kinase 0.0031 0.0217 0.022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0549 1
Leishmania major hypothetical protein, conserved 0.0028 0.0177 0.2499
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0549 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0819 0.8771 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.0042 0.0336 0.0324
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0077 0.0077
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0452 0.0457
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0031 0.0211 0.0213
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0177 0.2127
Schistosoma mansoni chromobox protein 0.0069 0.0628 0.085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0549 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0403 0.0543
Leishmania major cathepsin L-like protease 0.0062 0.0549 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0344 0.3874
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0077 0.0152
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.017
Echinococcus granulosus lysine specific demethylase 5A 0.0104 0.1002 0.1012
Loa Loa (eye worm) hypothetical protein 0.0026 0.0154 0.0116
Echinococcus granulosus chromobox protein 1 0.0069 0.0628 0.0635
Toxoplasma gondii exonuclease III APE 0.0038 0.0289 0.153
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0386 0.4065 0.5531
Entamoeba histolytica protein kinase, putative 0.0042 0.0336 0.3767
Schistosoma mansoni coup transcription factor 0.0386 0.4065 0.5531
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0386 0.4065 0.4601
Echinococcus granulosus RNA directed DNA polymerase 0.0072 0.0662 0.0669
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.1449 0.1464
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0158 0.1592 1
Brugia malayi orphan nuclear receptor NR2E1 0.0182 0.1852 0.2088
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0053 0.0054
Onchocerca volvulus 0.0016 0.0053 0.0053
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.1449 0.1626
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0386 0.4065 0.5531
Brugia malayi latrophilin 2 splice variant baaae 0.0236 0.2442 0.2761
Schistosoma mansoni lamin 0.0053 0.0452 0.0609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0177 0.0508
Brugia malayi Latrophilin receptor protein 2 0.0109 0.1064 0.1186
Brugia malayi jmjC domain containing protein 0.0028 0.0177 0.0172
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0344 0.0292
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0042 0.0336 0.0339
Echinococcus multilocularis lysine specific demethylase 5A 0.0104 0.1002 0.1012
Brugia malayi RhoGAP domain containing protein 0.003 0.0201 0.0199
Loa Loa (eye worm) hypothetical protein 0.0084 0.0793 0.0849
Schistosoma mansoni atypical protein kinase C 0.0171 0.1737 0.2361
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0344 0.0292
Brugia malayi nuclear receptor NHR-67 0.0182 0.1852 0.2088
Loa Loa (eye worm) hypothetical protein 0.0026 0.0161 0.0124
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0204 0.2089 0.284
Schistosoma mansoni unc-13 (munc13) 0.0034 0.025 0.0335
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0405 0.7098
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0109 0.1064 0.1075
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0549 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0158 0.1592 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0204 0.2089 0.211
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0149 0.1494 0.1509
Loa Loa (eye worm) hypothetical protein 0.0182 0.1852 0.2064
Loa Loa (eye worm) hypothetical protein 0.0114 0.1118 0.1221
Brugia malayi hypothetical protein 0.0036 0.0266 0.0274
Brugia malayi Steroid receptor seven-up type 2 0.0386 0.4065 0.4618
Echinococcus granulosus nuclear receptor nhr 48 0.0182 0.1852 0.1871
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0089 0.013
Brugia malayi jmjC domain containing protein 0.0028 0.0177 0.0172
Echinococcus multilocularis protein kinase c epsilon type 0.0161 0.1625 0.1642
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0862 0.087
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.1449 0.1968
Schistosoma mansoni protein kinase C mu 0.003 0.0201 0.0268
Brugia malayi nuclear hormone receptor 0.0386 0.4065 0.4618
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0042 0.0336 0.0339
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0158 0.1592 1
Echinococcus multilocularis neuropeptide s receptor 0.0923 0.99 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0104
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0177 0.0508
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0336 0.0284
Loa Loa (eye worm) hypothetical protein 0.0182 0.1852 0.2064
Loa Loa (eye worm) RasGEF domain-containing protein 0.003 0.0201 0.017
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0053 0.0066
Schistosoma mansoni jumonji/arid domain-containing protein 0.0104 0.1002 0.1359
Brugia malayi p70 ribosomal S6 kinase beta 0.0042 0.0336 0.0353
Echinococcus granulosus cathepsin l1 0.0016 0.0053 0.0054
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0289 0.4492
Onchocerca volvulus 0.003 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0049 0.0413 0.0413
Loa Loa (eye worm) raf kinase 0.003 0.0201 0.017
Echinococcus granulosus histone lysine methyltransferase setb 0.0118 0.1153 0.1164
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0289 0.2293
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0161 0.2179
Loa Loa (eye worm) hypothetical protein 0.0386 0.4065 0.4601
Plasmodium vivax SET domain protein, putative 0.0118 0.1153 0.7144
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0549 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0161 0.2179
Brugia malayi hypothetical protein 0.0204 0.2089 0.2358
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0386 0.4065 0.4106
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0452 0.0457
Brugia malayi hypothetical protein 0.0026 0.0161 0.0153
Schistosoma mansoni serine/threonine kinase 0.0042 0.0336 0.0451
Brugia malayi Nuclear hormone receptor-like 1 0.0204 0.2089 0.2358
Schistosoma mansoni hypothetical protein 0.0236 0.2442 0.332
Brugia malayi nuclear receptor NHR-88 0.0386 0.4065 0.4618
Onchocerca volvulus 0.0016 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0123 0.1214 0.1332
Onchocerca volvulus 0.0016 0.0053 0.0053
Brugia malayi Protein kinase c protein 2 0.0108 0.1045 0.1165
Loa Loa (eye worm) hypothetical protein 0.0053 0.0452 0.0457
Echinococcus multilocularis chromobox protein 1 0.0069 0.0628 0.0635
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0298 0.0246
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0386 0.4065 0.4106
Schistosoma mansoni nuclear hormone receptor 0.0182 0.1852 0.2518
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0386 0.4065 0.4618
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0109 0.1064 0.1075
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0289 0.4752
Brugia malayi Calcitonin receptor-like protein seb-1 0.0346 0.3629 0.4119
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0211 0.0282
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0346 0.3629 0.4119
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0077 0.0077
Echinococcus multilocularis serine:threonine protein kinase 38 0.0042 0.0336 0.0339
Loa Loa (eye worm) jmjC domain-containing protein 0.0104 0.1002 0.1088
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0386 0.4065 0.4618
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0549 1
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0336 0.0284
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0042 0.0336 0.0324
Loa Loa (eye worm) hypothetical protein 0.0065 0.058 0.0604
Loa Loa (eye worm) hypothetical protein 0.0386 0.4065 0.4601
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0158 0.1592 1
Entamoeba histolytica protein kinase, putative 0.0042 0.0336 0.3767
Brugia malayi Pleckstrin Homology Domain 0.003 0.0201 0.0199
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0104 0.1001 1
Echinococcus multilocularis FTZ F1 alpha 0.0386 0.4065 0.4106
Schistosoma mansoni inositol monophosphatase 0.0043 0.0344 0.0462
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0182 0.1852 0.1852
Leishmania major cathepsin L-like protease 0.0062 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.1852 0.2064
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.016
Brugia malayi tailless protein 0.0182 0.1852 0.2088
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0177 0.0179
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0289 0.8884
Echinococcus granulosus NDR protein kinase 0.0042 0.0336 0.0339
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0042 0.0336 0.0324
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0161 0.0701
Loa Loa (eye worm) hypothetical protein 0.0238 0.2458 0.2758
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0549 1
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0031 0.0211 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0549 1
Brugia malayi Nuclear hormone receptor E75 0.0182 0.1852 0.2088
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0386 0.4065 0.4106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0386 0.4065 0.4601
Schistosoma mansoni hypothetical protein 0.0029 0.0193 0.0256
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0628 0.0578
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0177 0.1081
Onchocerca volvulus 0.0084 0.0793 0.0793
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0336 0.0284
Entamoeba histolytica hypothetical protein 0.003 0.0201 0.1975
Echinococcus multilocularis lamin 0.0053 0.0452 0.0456
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0053 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0549 1
Brugia malayi diacylglycerol kinase 0.003 0.0201 0.0199
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0177 0.0508
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0862 0.087
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0077 0.0057
Brugia malayi Heterochromatin protein 1 0.0069 0.0628 0.0688
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0386 0.4065 0.5531
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0042 0.0336 0.0339
Schistosoma mansoni hypothetical protein 0.0109 0.1064 0.1444
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0177 0.1081
Schistosoma mansoni zinc finger protein 0.0182 0.1852 0.2518
Schistosoma mansoni hypothetical protein 0.0109 0.1064 0.1444
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0109 0.1064 0.1075
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0211 0.0282
Schistosoma mansoni nuclear hormone receptor 0.0386 0.4065 0.5531
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0386 0.4065 0.4618
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0549 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0182 0.1852 0.1871
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0182 0.1852 0.2088
Brugia malayi ecdysteroid receptor 0.0386 0.4065 0.4618
Echinococcus multilocularis peregrin 0.0033 0.0231 0.0233
Brugia malayi jmjC domain containing protein 0.0028 0.0177 0.0172
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0034 0.025 0.0253
Brugia malayi nuclear receptor NHR-88 0.0182 0.1852 0.2088
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0177 0.0171
Entamoeba histolytica hypothetical protein 0.0036 0.0266 0.2841
Brugia malayi Pre-SET motif family protein 0.0118 0.1153 0.1287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0549 1
Echinococcus granulosus ecdysone induced protein 78C 0.0386 0.4065 0.4106
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0177 0.1645
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0158 0.1592 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0177 0.0804
Brugia malayi photoreceptor-specific nuclear receptor 0.0386 0.4065 0.4618
Loa Loa (eye worm) hypothetical protein 0.0028 0.0177 0.0142
Echinococcus granulosus GPCR family 2 0.0109 0.1064 0.1075
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0177 0.2499
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0346 0.3629 0.4101
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0177 0.0508
Onchocerca volvulus 0.0028 0.0177 0.0177
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0386 0.4065 0.4106
Echinococcus granulosus phd:f box containing protein 0.0028 0.0177 0.0179
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0161 0.0701
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.017
Echinococcus granulosus thyroid hormone receptor alpha 0.0182 0.1852 0.1871
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0177 0.0179
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0403 0.043
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0078 0.0721 0.0766
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0468 0.1375
Onchocerca volvulus 0.0182 0.1852 0.1852
Entamoeba histolytica hypothetical protein 0.0036 0.0266 0.2841
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0336 0.0284
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0077 0.0152
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0053 0.0054
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0109 0.1064 0.1075
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0182 0.1852 0.1871
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0177 0.0179
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0339 0.1858
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0177 0.0179
Echinococcus multilocularis thyroid hormone receptor alpha 0.0386 0.4065 0.4106
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0177 0.0171
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0055
Brugia malayi hypothetical protein 0.0238 0.2458 0.278
Loa Loa (eye worm) hypothetical protein 0.0182 0.1852 0.2064
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0177 0.0142
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0077 0.0152
Brugia malayi Cathepsin L-like precursor 0.0016 0.0053 0.003
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0028 0.0177 0.0804
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0182 0.1852 0.2064
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0185 0.0151
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.017
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0042 0.0336 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0386 0.4065 0.4618
Schistosoma mansoni microtubule-associated protein tau 0.0688 0.7345 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0549 1
Schistosoma mansoni diacylglycerol kinase theta 0.003 0.0201 0.0268
Onchocerca volvulus Protein ultraspiracle homolog 0.0386 0.4065 0.4065
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0031 0.0211 0.0211
Loa Loa (eye worm) latrophilin receptor protein 2 0.0109 0.1064 0.1159
Schistosoma mansoni ap endonuclease 0.0038 0.0289 0.0387
Schistosoma mansoni thyroid hormone receptor 0.0386 0.4065 0.5531
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0193 0.016
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0344 0.5865
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0289 0.4752
Echinococcus granulosus jumonji domain containing protein 0.004 0.0316 0.0319
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.033 0.033
Loa Loa (eye worm) nuclear receptor NHR-67 0.0182 0.1852 0.2064
Schistosoma mansoni thyroid hormone receptor 0.0386 0.4065 0.5531
Schistosoma mansoni ap endonuclease 0.0038 0.0289 0.0387
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0301 0.33
Brugia malayi Bromodomain containing protein 0.0033 0.0231 0.0233
Schistosoma mansoni RAR-like nuclear receptor 0.0386 0.4065 0.5531
Onchocerca volvulus 0.003 0.0201 0.0201
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0266 0.0269
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0177 0.0179
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0193 0.0905
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0161 0.1792
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0109 0.1064 0.1186
Brugia malayi Cathepsin L-like precursor 0.0016 0.0053 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0549 1
Onchocerca volvulus Huntingtin homolog 0.0123 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0204 0.2089 0.2335
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0628 0.066
Entamoeba histolytica PH domain containing protein kinase, putative 0.0085 0.0803 1
Echinococcus multilocularis lamin dm0 0.0053 0.0452 0.0456
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0053 0.003
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0158 0.1592 1
Schistosoma mansoni nuclear receptor 0.0182 0.1852 0.2518
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0182 0.1852 0.2518
Schistosoma mansoni hypothetical protein 0.003 0.0201 0.0268
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0193 0.0194
Echinococcus multilocularis geminin 0.0508 0.5391 0.5445
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0177 0.0179
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0177 0.0235
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0182 0.1852 0.1871
Loa Loa (eye worm) hypothetical protein 0.0204 0.2089 0.2335
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0113 0.1106 0.1117
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0185 0.0181
Entamoeba histolytica diacylglycerol kinase, putative 0.003 0.0201 0.1975
Loa Loa (eye worm) hypothetical protein 0.0039 0.0298 0.0281
Loa Loa (eye worm) hypothetical protein 0.0084 0.0793 0.0849
Schistosoma mansoni protein kinase C 0.0034 0.025 0.0335
Brugia malayi Variant SH3 domain containing protein 0.003 0.0201 0.0199
Echinococcus multilocularis Rac GTPase activating protein 1 0.003 0.0201 0.0203
Echinococcus multilocularis myotubularin protein 13 0.003 0.0201 0.0203
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0077 0.0027
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0289 0.0292
Loa Loa (eye worm) hypothetical protein 0.0182 0.1852 0.2064
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0344 0.1888
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0129 0.1276 0.1732
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0386 0.4065 0.4106
Echinococcus multilocularis serotonin receptor 0.0065 0.058 0.0586
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0193 0.0905
Loa Loa (eye worm) hypothetical protein 0.0034 0.025 0.0226
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0336 0.0284
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0053 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0298 0.0246
Loa Loa (eye worm) TK/FAK protein kinase 0.0355 0.3736 0.4225
Schistosoma mansoni chromobox protein 0.0069 0.0628 0.085
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0386 0.4065 0.4618
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0339 0.1858
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0177 0.0235
Loa Loa (eye worm) hypothetical protein 0.0084 0.0793 0.0849
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.003 0.0201 0.017
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0289 0.3139
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0104 0.1001 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0177 0.0235
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0289 0.027
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0158 0.1592 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.1153 0.1564
Echinococcus multilocularis protein kinase c iota type 0.0165 0.1664 0.1681
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0041 0.0326 0.0274
Loa Loa (eye worm) RhoGAP domain-containing protein 0.003 0.0201 0.017
Echinococcus multilocularis musashi 0.0053 0.0452 0.0456
Echinococcus granulosus neuropeptide receptor A26 0.0923 0.99 1
Echinococcus granulosus lamin 0.0053 0.0452 0.0456
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0386 0.4065 0.4618
Brugia malayi SET domain containing protein 0.0016 0.0047 0.0023
Trypanosoma brucei rac serine-threonine kinase, putative 0.0042 0.0336 0.549
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0628 0.0578
Echinococcus granulosus protein tyrosine kinase 0.0351 0.3691 0.3728
Brugia malayi conserved hypotetical protein 0.0182 0.1852 0.2088
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0336 0.0284
Trichomonas vaginalis set domain proteins, putative 0.0932 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0289 0.4752
Brugia malayi nuclear hormone receptor 0.0182 0.1852 0.2088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0386 0.4065 0.4601
Onchocerca volvulus Bile acid receptor homolog 0.0386 0.4065 0.4065
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.8415 0.85
Echinococcus granulosus myotubularin protein 13 0.003 0.0201 0.0203
Loa Loa (eye worm) hypothetical protein 0.0182 0.1852 0.2064
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0413 0.0557
Echinococcus granulosus biogenic amine 5HT receptor 0.0065 0.058 0.0586
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0042 0.0336 0.0339
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0077 0.0472
Loa Loa (eye worm) hypothetical protein 0.0204 0.2089 0.2335
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0289 0.0237
Brugia malayi Nuclear hormone receptor-like 1 0.0386 0.4065 0.4618
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0042 0.0336 0.0339
Brugia malayi nuclear hormone receptor family member odr-7 0.0182 0.1852 0.2088
Toxoplasma gondii AGC kinase 0.0042 0.0336 0.1836
Schistosoma mansoni jumonji domain containing protein 0.0144 0.1441 0.1957
Brugia malayi Cathepsin L-like precursor 0.0016 0.0053 0.003
Toxoplasma gondii diacylglycerol kinase, putative 0.003 0.0201 0.0962
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0177 0.0508
Brugia malayi Pre-SET motif family protein 0.0819 0.8771 1
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0072 0.0662 0.0669
Echinococcus granulosus N chimaerin 0.003 0.0201 0.0203
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.013 0.1289 0.1417
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0528 0.0545
Brugia malayi hypothetical protein 0.0204 0.2089 0.2358
Brugia malayi Inositol-1 0.0043 0.0344 0.0362
Loa Loa (eye worm) variant SH3 domain-containing protein 0.003 0.0201 0.017
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0204 0.2089 0.2335
Schistosoma mansoni jumonji/arid domain-containing protein 0.0104 0.1002 0.1359
Schistosoma mansoni hypothetical protein 0.0508 0.5391 0.7338
Brugia malayi nuclear receptor RXR 0.0182 0.1852 0.2088
Brugia malayi Protein kinase domain containing protein 0.0042 0.0336 0.0353
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0154 0.0156
Brugia malayi Protein kinase domain containing protein 0.0042 0.0336 0.0353
Brugia malayi hypothetical protein 0.0017 0.0061 0.0038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0386 0.4065 0.4618
Schistosoma mansoni inositol monophosphatase 0.0043 0.0344 0.0462
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0042 0.0336 0.0324
Loa Loa (eye worm) hypothetical protein 0.0028 0.0177 0.0142
Echinococcus granulosus microtubule associated protein 2 0.0688 0.7345 0.7419
Loa Loa (eye worm) hypothetical protein 0.0386 0.4065 0.4601
Brugia malayi diacylglycerol kinase 0.003 0.0201 0.0199
Brugia malayi Nuclear hormone receptor-like 1 0.0204 0.2089 0.2358
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0054 0.0468 0.2058
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0193 0.0194
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0339 0.1858
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0055
Schistosoma mansoni hypothetical protein 0.0048 0.0403 0.0543
Loa Loa (eye worm) hypothetical protein 0.003 0.0207 0.0177
Echinococcus granulosus chromobox protein 1 0.0069 0.0628 0.0635
Echinococcus multilocularis protein kinase c eta type 0.003 0.0201 0.0203
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0177 0.0508
Echinococcus granulosus serine:threonine protein kinase N2 0.0042 0.0336 0.0339
Echinococcus granulosus protein kinase c epsilon type 0.0161 0.1625 0.1642
Echinococcus multilocularis unc 13 (munc13) 0.0034 0.025 0.0253
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0452 0.0486
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0301 1
Schistosoma mansoni intermediate filament proteins 0.0053 0.0452 0.0609
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0104
Echinococcus multilocularis tumor protein p63 0.0338 0.3542 0.3578
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0386 0.4065 0.4601
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0862 0.1168
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0175 0.0123
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0204 0.2089 0.211
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0118 0.1153 0.1164
Loa Loa (eye worm) hypothetical protein 0.0118 0.1153 0.1261
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0089 0.013
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0289 0.153
Echinococcus granulosus serine:threonine protein kinase N2 0.0085 0.0803 0.0811
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.1405 0.1419
Schistosoma mansoni protein kinase C mu 0.0031 0.0211 0.0282
Echinococcus granulosus lamin dm0 0.0053 0.0452 0.0456
Plasmodium vivax JmjC domain containing protein 0.0028 0.0177 0.0804
Loa Loa (eye worm) hypothetical protein 0.0028 0.0177 0.0142
Onchocerca volvulus 0.003 0.0207 0.0207
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0386 0.4065 0.4106
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0344 0.566
Loa Loa (eye worm) hypothetical protein 0.0182 0.1852 0.2064
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0336 0.0451
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0104 0.1001 0.5825
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0386 0.4065 0.4618
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0118 0.1153 0.7144
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0177 0.249
Brugia malayi Cathepsin L-like precursor 0.0016 0.0053 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.1494 0.203
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0161 0.1625 0.1803
Loa Loa (eye worm) hypothetical protein 0.0123 0.1214 0.1332
Echinococcus multilocularis chromobox protein 1 0.0069 0.0628 0.0635
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0177 0.0235
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0336 0.0284
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0034 0.025 0.0253
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0177 0.0142
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0336 0.0451
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0549 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0127 0.1252 0.1265
Brugia malayi Cathepsin L-like precursor 0.0016 0.0053 0.003
Loa Loa (eye worm) acetyltransferase 0.0145 0.1449 0.1601
Loa Loa (eye worm) hypothetical protein 0.0052 0.0441 0.0445
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0301 0.1608
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0028 0.0177 0.0804
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0101 0.0309
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0386 0.4065 0.4106
Schistosoma mansoni diacylglycerol kinase theta 0.003 0.0201 0.0268
Echinococcus multilocularis Diacylglycerol kinase theta 0.003 0.0201 0.0203
Brugia malayi intermediate filament protein 0.0053 0.0452 0.0486
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0077 0.0077
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0344 0.0292
Brugia malayi Probable ClpP-like protease 0.0158 0.1592 0.179
Echinococcus multilocularis microtubule associated protein 2 0.0688 0.7345 0.7419
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0089 0.013
Trichomonas vaginalis chromobox protein, putative 0.0042 0.033 0.0278
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0289 0.153
Loa Loa (eye worm) hypothetical protein 0.0182 0.1852 0.2064
Brugia malayi C1-like domain containing protein 0.0031 0.0211 0.0211
Onchocerca volvulus 0.0049 0.0413 0.0413
Echinococcus multilocularis protein tyrosine kinase 0.0351 0.3691 0.3728
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0386 0.4065 0.4106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0386 0.4065 0.4601
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0386 0.4065 0.4618
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0004 0.0005
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0336 0.0284
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0862 0.0927
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0101 0.0309
Loa Loa (eye worm) hypothetical protein 0.0158 0.1592 0.1765
Leishmania major hypothetical protein, conserved 0.0026 0.0161 0.2179
Onchocerca volvulus Huntingtin homolog 0.0123 0.1214 0.1214
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0289 0.0237
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0289 0.0292
Entamoeba histolytica protein kinase, putative 0.0042 0.0336 0.3767
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0468 0.2694
Echinococcus granulosus neuropeptide s receptor 0.0923 0.99 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0386 0.4065 0.4065
Loa Loa (eye worm) DR-78 0.0182 0.1852 0.2064
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0177 0.0235
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0053 0.0054
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0053 0.0053
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0177 0.249
Loa Loa (eye worm) nuclear hormone receptor 0.0182 0.1852 0.2064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.1153 0.1564
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0386 0.4065 0.4106
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.003 0.0201 0.0268
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.1153 0.1564
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.017
Schistosoma mansoni hypothetical protein 0.0109 0.1064 0.1444
Echinococcus granulosus FTZ F1 alpha 0.0386 0.4065 0.4106
Echinococcus multilocularis ecdysone induced protein 78C 0.0386 0.4065 0.4106
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.049 0.8824
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0468 0.2694
Echinococcus granulosus tumor protein p63 0.0338 0.3542 0.3578
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0158 0.1592 1
Brugia malayi hypothetical protein 0.0182 0.1852 0.2088
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0161 0.0701
Schistosoma mansoni nuclear receptor 0.0182 0.1852 0.2518
Brugia malayi Cathepsin L-like precursor 0.0016 0.0053 0.003
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0177 0.0142
Echinococcus multilocularis serotonin receptor 0.0065 0.058 0.0586
Brugia malayi nuclear hormone receptor family member nhr-6 0.0182 0.1852 0.2088
Schistosoma mansoni tyrosine kinase 0.0351 0.3691 0.5022
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0339 0.0288
Brugia malayi hypothetical protein 0.0123 0.1214 0.1358
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0336 0.0451
Loa Loa (eye worm) AGC/NDR protein kinase 0.0042 0.0336 0.0324
Brugia malayi nuclear receptor RXR 0.0204 0.2089 0.2358
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0042 0.0336 0.0339
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0339 0.0288
Trichomonas vaginalis chromobox protein, putative 0.0042 0.033 0.0278
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0386 0.4065 0.4618
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.2458 0.2483
Loa Loa (eye worm) hypothetical protein 0.0021 0.0101 0.0055
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0182 0.1852 0.1871
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0316 0.0319
Loa Loa (eye worm) hypothetical protein 0.0386 0.4065 0.4601
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0177 0.0508
Onchocerca volvulus 0.0048 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0204 0.2089 0.2335
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0193 0.0256
Echinococcus multilocularis N chimaerin 0.003 0.0201 0.0203
Onchocerca volvulus 0.0053 0.0452 0.0452
Schistosoma mansoni steroid hormone receptor ad4bp 0.0386 0.4065 0.5531
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0182 0.1852 0.1871
Brugia malayi Protein kinase domain containing protein 0.0355 0.3736 0.4242
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.017
Loa Loa (eye worm) hypothetical protein 0.0182 0.1852 0.2064
Echinococcus granulosus Rac GTPase activating protein 1 0.003 0.0201 0.0203
Schistosoma mansoni hypothetical protein 0.0036 0.0266 0.0357
Loa Loa (eye worm) steroid hormone receptor 0.0386 0.4065 0.4601
Echinococcus multilocularis peptidase Clp (S14 family) 0.0104 0.1001 0.1011
Entamoeba histolytica protein kinase, putative 0.0042 0.0336 0.3767
Loa Loa (eye worm) hypothetical protein 0.0068 0.0616 0.0646
Loa Loa (eye worm) hypothetical protein 0.0204 0.2089 0.2335
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0182 0.1852 0.2518
Leishmania major cathepsin L-like protease 0.0062 0.0549 1
Onchocerca volvulus 0.0034 0.025 0.025
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.003 0.0201 0.0268
Echinococcus granulosus protein kinase c eta type 0.003 0.0201 0.0203
Loa Loa (eye worm) AGC/AKT protein kinase 0.0042 0.0336 0.0324
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0077 0.0077
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0177 0.1645
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0177 0.1645
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0182 0.1852 0.1852
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0344 0.1629
Onchocerca volvulus 0.0016 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0028 0.0177 0.0142
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0053 0.0054
Brugia malayi RhoGAP domain containing protein 0.003 0.0201 0.0199
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0177 0.0171
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0344 0.0347
Schistosoma mansoni lamin 0.0053 0.0452 0.0609
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.1625 0.2208
Loa Loa (eye worm) inositol-1 0.0043 0.0344 0.0333
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.017
Brugia malayi steroid hormone receptor 0.0386 0.4065 0.4618
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0344 0.5865
Echinococcus granulosus peregrin 0.0033 0.0231 0.0233
Brugia malayi PHD-finger family protein 0.0029 0.0193 0.0189
Schistosoma mansoni nuclear receptor nhr-48 0.0182 0.1852 0.2518
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0386 0.4065 0.4106
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0344 0.0347
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0289 0.1259
Echinococcus multilocularis cysteine protease 0.0016 0.0053 0.0054
Plasmodium falciparum phd finger protein, putative 0.0029 0.0193 0.0905
Loa Loa (eye worm) hypothetical protein 0.0182 0.1852 0.2064
Brugia malayi Nuclear hormone receptor E75 0.0182 0.1852 0.2088
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0028 0.0177 0.2499
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0336 0.0284
Echinococcus multilocularis GPCR, family 2 0.0109 0.1064 0.1075
Brugia malayi protein kinase C3,putative 0.0123 0.1215 0.1358
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0164 0.1654 0.167
Loa Loa (eye worm) hypothetical protein 0.0386 0.4065 0.4601
Echinococcus granulosus intermediate filament protein 0.0053 0.0452 0.0456
Loa Loa (eye worm) hypothetical protein 0.003 0.0201 0.017
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0053 0.0054
Echinococcus granulosus Nuclear hormone receptor HR96 0.0182 0.1852 0.1871
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0164 0.1654 0.167
Brugia malayi jmjC domain containing protein 0.0028 0.0177 0.0172
Onchocerca volvulus 0.0129 0.1276 0.1276
Brugia malayi jmjC domain containing protein 0.0104 0.1002 0.1115
Onchocerca volvulus Alhambra homolog 0.0029 0.0193 0.0193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0862 0.087
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.003 0.0201 0.0203
Echinococcus granulosus protein kinase c iota type 0.0165 0.1664 0.1681
Onchocerca volvulus 0.0016 0.0053 0.0053
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0266 0.0269
Trichomonas vaginalis AGC family protein kinase 0.0042 0.0336 0.0284
Schistosoma mansoni hypothetical protein 0.0508 0.5391 0.7338
Loa Loa (eye worm) hypothetical protein 0.0236 0.2442 0.274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0386 0.4065 0.4601
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0346 0.3629 0.4101
Brugia malayi chromobox protein homolog 3 0.0039 0.0298 0.031
Loa Loa (eye worm) hypothetical protein 0.0386 0.4065 0.4601
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0027 0.0031
Brugia malayi Ras association domain family 1 isoform A 0.003 0.0201 0.0199
Toxoplasma gondii hypothetical protein 0.0054 0.0468 0.2694

Activities

Activity type Activity value Assay description Source Reference
Mean (functional) = 66.6 Mean of rate of formation in all human liver microsomes. ChEMBL. 1681107
pmol (functional) = 32 min-1 Compound was tested for the rate of formation in human liver microsomes 112 ChEMBL. 1681107
pmol (functional) = 58.8 min-1 Compound was tested for the rate of formation in human liver microsomes 114 ChEMBL. 1681107
pmol (functional) = 74.9 min-1 Compound was tested for the rate of formation in human liver microsomes 116 ChEMBL. 1681107
pmol (functional) = 96.1 min-1 Compound was tested for the rate of formation in rat liver microsomes ChEMBL. 1681107
pmol (functional) = 101 min-1 Compound was tested for the rate of formation in human liver microsomes 108 ChEMBL. 1681107
Rate of formation (functional) = 32 pM min-1 (mg of protein)-1 Compound was tested for the rate of formation in human liver microsomes 112 ChEMBL. 1681107
Rate of formation (functional) = 58.8 pM min-1 (mg of protein)-1 Compound was tested for the rate of formation in human liver microsomes 114 ChEMBL. 1681107
Rate of formation (functional) = 74.9 pM min-1 (mg of protein)-1 Compound was tested for the rate of formation in human liver microsomes 116 ChEMBL. 1681107
Rate of formation (functional) = 101 pM min-1 (mg of protein)-1 Compound was tested for the rate of formation in human liver microsomes 108 ChEMBL. 1681107

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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