Detailed information for compound 1739889

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 412.48 | Formula: C21H21FN4O2S
  • H donors: 2 H acceptors: 2 LogP: 3.21 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C(Nc1ccccc1)NCC(=O)N1CCC(CC1)c1noc2c1ccc(c2)F
  • InChi: 1S/C21H21FN4O2S/c22-15-6-7-17-18(12-15)28-25-20(17)14-8-10-26(11-9-14)19(27)13-23-21(29)24-16-4-2-1-3-5-16/h1-7,12,14H,8-11,13H2,(H2,23,24,29)
  • InChiKey: TZUFJSIDMNZQSK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0174 0.2585
Trypanosoma brucei unspecified product 0.0017 0.0174 0.2585
Trypanosoma brucei unspecified product 0.0012 0.0051 0.0421
Brugia malayi MH2 domain containing protein 0.0013 0.0087 0.006
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0012 0.0054 0.0027
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0064 0.128 0.1269
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0064 0.128 0.1257
Plasmodium falciparum importin beta, putative 0.0017 0.0184 0.2911
Brugia malayi hypothetical protein 0.0278 0.6294 0.6284
Brugia malayi Pre-SET motif family protein 0.0043 0.0773 0.0748
Entamoeba histolytica hypothetical protein, conserved 0.0305 0.6922 1
Echinococcus granulosus Diacylglycerol kinase theta 0.0012 0.0054 0.0027
Brugia malayi MH2 domain containing protein 0.0013 0.0087 0.006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0043 0.0773 0.1082
Schistosoma mansoni hypothetical protein 0.0103 0.2196 0.3146
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0013 0.0076 0.0049
Echinococcus granulosus GPCR family 2 0.0024 0.0333 0.0308
Plasmodium vivax diacylglycerol kinase, putative 0.0012 0.0054 0.0537
Trichomonas vaginalis bmru protein, putative 0.0012 0.0054 0.0036
Mycobacterium leprae conserved hypothetical protein 0.0022 0.029 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0174 0.2585
Trichomonas vaginalis ran, putative 0.0013 0.0076 0.0064
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0012 0.0054 0.0171
Mycobacterium leprae Probable lipase LipE 0.0022 0.029 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0017 0.0184 0.2743
Mycobacterium tuberculosis Conserved protein 0.0022 0.029 0.0418
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0064 0.128 0.1257
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0054 0.0039
Onchocerca volvulus 0.0022 0.029 0.0309
Schistosoma mansoni sphingoid long chain base kinase 0.0305 0.6922 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0013 0.0076 0.0063
Echinococcus multilocularis beta LACTamase domain containing family member 0.0022 0.029 0.0264
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0174 0.0234
Loa Loa (eye worm) hypothetical protein 0.0051 0.0981 0.0969
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0064 0.128 0.1257
Echinococcus multilocularis dna polymerase kappa 0.0017 0.0174 0.0148
Brugia malayi Smad1 0.0013 0.0087 0.006
Plasmodium vivax SET domain protein, putative 0.0043 0.0773 1
Loa Loa (eye worm) Smad1 0.0013 0.0087 0.0074
Schistosoma mansoni hypothetical protein 0.0012 0.0054 0.0039
Trypanosoma cruzi PAB1-binding protein , putative 0.0035 0.0599 1
Echinococcus multilocularis snurportin 1 0.0186 0.4132 0.4117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0043 0.0773 0.1082
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.001 0.0013 0.0019
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0054 0.0476
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0054 0.0476
Trypanosoma brucei diacylglycerol kinase, putative 0.0012 0.0054 0.0476
Mycobacterium ulcerans hypothetical protein 0.0014 0.0093 0.0116
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.128 0.1818
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0075 0.1539 0.1516
Trypanosoma brucei importin beta-1 subunit, putative 0.0017 0.0184 0.2743
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0174 0.0162
Onchocerca volvulus 0.0022 0.029 0.0309
Trypanosoma cruzi DNA polymerase eta, putative 0.0017 0.0174 0.2585
Loa Loa (eye worm) hypothetical protein 0.0305 0.6922 0.6918
Echinococcus granulosus dna polymerase eta 0.0017 0.0174 0.0148
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0022 0.029 0.0418
Echinococcus multilocularis muscleblind protein 0.0436 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0017 0.0174 0.0234
Mycobacterium tuberculosis Probable esterase LipL 0.0022 0.029 0.0418
Brugia malayi beta-lactamase 0.0022 0.029 0.0264
Echinococcus granulosus smad 0.0013 0.0087 0.006
Schistosoma mansoni hypothetical protein 0.0051 0.0981 0.1384
Plasmodium vivax ataxin-2 like protein, putative 0.0035 0.0599 0.7711
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0013 0.0076 0.086
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.029 0.4599
Schistosoma mansoni smad1 5 8 and 0.0013 0.0087 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0174 0.2585
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0024 0.0333 0.0308
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.128 0.1818
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0054 0.0036
Mycobacterium ulcerans hypothetical protein 0.0022 0.029 0.04
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0043 0.0773 0.0748
Plasmodium vivax hypothetical protein, conserved 0.0022 0.029 0.3642
Leishmania major 4-coumarate:coa ligase-like protein 0.0014 0.0093 0.0419
Mycobacterium tuberculosis Probable hydrolase 0.0022 0.029 0.0418
Loa Loa (eye worm) hypothetical protein 0.0043 0.0773 0.0761
Echinococcus multilocularis mothers against decapentaplegic 5 0.0013 0.0087 0.006
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0013 0.0076 0.0826
Leishmania major GTP-binding protein, putative 0.0013 0.0076 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0174 0.2585
Plasmodium vivax importin-beta 2, putative 0.0017 0.0184 0.2245
Onchocerca volvulus 0.0338 0.7689 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0017 0.0174 0.0928
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0043 0.0773 0.4678
Echinococcus multilocularis survival motor neuron protein 1 0.0278 0.6294 0.6284
Schistosoma mansoni Smad4 0.0013 0.0087 0.0087
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0012 0.0054 0.0039
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0013 0.0076 0.086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0043 0.0773 0.1082
Mycobacterium ulcerans diacylglycerol kinase 0.0012 0.0054 0.0059
Plasmodium falciparum ataxin-2 like protein, putative 0.0035 0.0599 1
Entamoeba histolytica hypothetical protein 0.0014 0.0106 0.0116
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0079 0.1622 0.1599
Trypanosoma cruzi PAB1-binding protein , putative 0.0035 0.0599 1
Loa Loa (eye worm) ceramide kinase 0.0012 0.0054 0.0041
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0012 0.0054 0.0039
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0054 0.0039
Trichomonas vaginalis penicillin-binding protein, putative 0.0022 0.029 0.0343
Leishmania major hypothetical protein, conserved 0.0012 0.0054 0.0171
Loa Loa (eye worm) hypothetical protein 0.0436 1 1
Brugia malayi MH1 domain containing protein 0.0013 0.0087 0.006
Echinococcus granulosus dna polymerase kappa 0.0017 0.0174 0.0148
Schistosoma mansoni hypothetical protein 0.0057 0.1105 0.1564
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0017 0.0174 0.0252
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0093 0.0116
Trichomonas vaginalis DNA polymerase eta, putative 0.0017 0.0174 0.0193
Echinococcus multilocularis dna polymerase eta 0.0017 0.0174 0.0148
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0014 0.0093 0.0116
Schistosoma mansoni survival motor neuron protein 0.0057 0.1105 0.1564
Echinococcus multilocularis geminin 0.0103 0.2196 0.2175
Brugia malayi Importin beta-1 subunit 0.0017 0.0184 0.0157
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0.0174 0.0215
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0054 0.0036
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0093 0.0067
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0013 0.0076 0.3327
Mycobacterium tuberculosis Probable lipase LipE 0.0022 0.029 0.0418
Schistosoma mansoni hypothetical protein 0.0186 0.4132 0.5954
Loa Loa (eye worm) beta-lactamase 0.0022 0.029 0.0277
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0024 0.0333 0.0308
Mycobacterium tuberculosis Conserved protein 0.0022 0.029 0.0418
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0093 0.0116
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0041
Echinococcus granulosus histone lysine methyltransferase setb 0.0043 0.0773 0.0748
Loa Loa (eye worm) hypothetical protein 0.0014 0.0093 0.008
Loa Loa (eye worm) MH2 domain-containing protein 0.0195 0.4344 0.4336
Trichomonas vaginalis D-aminoacylase, putative 0.0022 0.029 0.0343
Schistosoma mansoni ran 0.0013 0.0076 0.0071
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0043 0.0773 0.0748
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0174 0.2585
Brugia malayi hypothetical protein 0.0012 0.0054 0.0027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0014 0.0093 0.0097
Loa Loa (eye worm) hypothetical protein 0.0022 0.029 0.0277
Trypanosoma brucei PAB1-binding protein , putative 0.0035 0.0599 1
Onchocerca volvulus 0.0043 0.0773 0.0942
Trichomonas vaginalis D-aminoacylase, putative 0.0022 0.029 0.0343
Loa Loa (eye worm) hypothetical protein 0.0024 0.0333 0.0321
Schistosoma mansoni importin beta-1 0.0017 0.0184 0.0228
Mycobacterium ulcerans aldehyde dehydrogenase 0.0079 0.1622 0.2328
Leishmania major DNA polymerase eta, putative 0.0017 0.0174 0.0928
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0054 0.0476
Echinococcus multilocularis muscleblind protein 1 0.0436 1 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0013 0.0076 0.0309
Brugia malayi diacylglycerol kinase 0.0012 0.0054 0.0027
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0054 0.0039
Loa Loa (eye worm) hypothetical protein 0.0022 0.029 0.0277
Leishmania major importin beta-1 subunit, putative 0.0014 0.0106 0.05
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0093 0.0116
Mycobacterium ulcerans esterase/lipase LipP 0.0022 0.029 0.04
Echinococcus granulosus TGF beta signal transducer SmadC 0.0013 0.0087 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0174 0.2585
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0017 0.0174 0.0193
Schistosoma mansoni ran 0.0013 0.0076 0.0071
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0174 0.2585
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0773 0.1082
Loa Loa (eye worm) hypothetical protein 0.0022 0.029 0.0277
Trichomonas vaginalis penicillin-binding protein, putative 0.0022 0.029 0.0343
Mycobacterium ulcerans lipase LipD 0.0022 0.029 0.04
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0013 0.0076 0.086
Schistosoma mansoni hypothetical protein 0.0024 0.0333 0.0445
Toxoplasma gondii aldehyde dehydrogenase 0.0079 0.1622 1
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0012 0.0054 0.0041
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0054 0.0036
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0011 0.0027 0.0038
Echinococcus granulosus beta LACTamase domain containing family member 0.0022 0.029 0.0264
Loa Loa (eye worm) MH2 domain-containing protein 0.0013 0.0087 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.029 0.4599
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0186 0.4132 0.4125
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0011 0.0027 0.0179
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0022 0.029 0.0277
Trypanosoma brucei DNA polymerase IV, putative 0.0017 0.0174 0.2585
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0012 0.0054 0.0476
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0174 0.2585
Plasmodium falciparum ataxin-2 like protein, putative 0.0035 0.0599 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0079 0.1622 0.2328
Mycobacterium tuberculosis Diacylglycerol kinase 0.0012 0.0054 0.0078
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0012 0.0054 0.0171
Brugia malayi Pre-SET motif family protein 0.0297 0.6728 0.672
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0041
Schistosoma mansoni smad 0.0013 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0017 0.0184 0.0171
Loa Loa (eye worm) hypothetical protein 0.0022 0.029 0.0277
Entamoeba histolytica Ran family GTPase 0.0013 0.0076 0.0071
Echinococcus granulosus snurportin 1 0.0186 0.4132 0.4117
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0054 0.0039
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0013 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0024 0.0333 0.0445
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0051 0.0421
Mycobacterium tuberculosis Conserved protein 0.0305 0.6922 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.001 0.0013 0.5
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0022 0.029 0.0418
Trichomonas vaginalis esterase, putative 0.0022 0.029 0.0343
Toxoplasma gondii diacylglycerol kinase, putative 0.0012 0.0054 0.0171
Brugia malayi beta-lactamase family protein 0.0022 0.029 0.0264
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0022 0.029 0.0382
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0054 0.0476
Trichomonas vaginalis set domain proteins, putative 0.0338 0.7689 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0093 0.008
Giardia lamblia DINP protein human, muc B family 0.0017 0.0174 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0011 0.0027 0.5
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0079 0.1622 0.1599
Brugia malayi Diacylglycerol kinase protein 2 0.0012 0.0054 0.0027
Brugia malayi latrophilin 2 splice variant baaae 0.0051 0.0981 0.0957
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0174 0.2585
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0013 0.0076 0.0049
Onchocerca volvulus 0.0014 0.0093 0.0052
Echinococcus granulosus mothers against decapentaplegic 5 0.0013 0.0087 0.006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0093 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0174 0.2585
Toxoplasma gondii LsmAD domain-containing protein 0.0035 0.0599 0.3588
Echinococcus multilocularis importin subunit beta 1 0.0017 0.0184 0.0157
Brugia malayi Ceramide kinase 0.0012 0.0054 0.0027
Brugia malayi beta-lactamase family protein 0.0022 0.029 0.0264
Echinococcus granulosus Diacylglycerol kinase zeta 0.0012 0.0054 0.0027
Plasmodium vivax diacylglycerol kinase, putative 0.0012 0.0054 0.0537
Leishmania major hypothetical protein, conserved 0.0035 0.0599 0.3588
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0016 0.0145 0.0118
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0011 0.0027 0.0014
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0054 0.0476
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0174 0.0148
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0041 0.0736 0.0711
Brugia malayi diacylglycerol kinase 0.0012 0.0054 0.0027
Toxoplasma gondii ABC1 family protein 0.0022 0.029 0.165
Mycobacterium ulcerans hypothetical protein 0.0305 0.6922 1
Brugia malayi hypothetical protein 0.0023 0.0307 0.0281
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0054 0.0036
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0014 0.0106 0.0104
Onchocerca volvulus 0.0022 0.029 0.0309
Echinococcus multilocularis GPCR, family 2 0.0024 0.0333 0.0308
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0014 0.0093 0.0116
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0054 0.0476
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0011 0.0027 0.0232
Brugia malayi Calcitonin receptor-like protein seb-1 0.0075 0.1539 0.1516
Echinococcus granulosus geminin 0.0103 0.2196 0.2175
Schistosoma mansoni smad1 5 8 and 0.0013 0.0087 0.0087
Trichomonas vaginalis D-aminoacylase, putative 0.0022 0.029 0.0343
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0064 0.128 0.1257
Leishmania major 4-coumarate:coa ligase-like protein 0.0014 0.0093 0.0419
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0024 0.0333 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0051 0.0421
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0011 0.0027 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0054 0.0041
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0022 0.029 0.0382
Echinococcus multilocularis Diacylglycerol kinase theta 0.0012 0.0054 0.0027
Mycobacterium tuberculosis Probable lipase LipD 0.0022 0.029 0.0418
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0297 0.6728 0.6724
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0022 0.029 0.0264
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0054 0.0036
Toxoplasma gondii HEAT repeat-containing protein 0.0017 0.0184 0.0984
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0174 0.2585
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0174 0.0148
Schistosoma mansoni smad1 5 8 and 0.0013 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0035 0.0599 0.0587
Loa Loa (eye worm) diacylglycerol kinase 2 0.0012 0.0054 0.0041
Trypanosoma brucei unspecified product 0.0012 0.0051 0.0421
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0016 0.0145 0.0118
Loa Loa (eye worm) MH1 domain-containing protein 0.0013 0.0087 0.0074
Mycobacterium tuberculosis Conserved protein 0.0022 0.029 0.0418
Schistosoma mansoni hypothetical protein 0.0016 0.0145 0.0171
Echinococcus multilocularis Smad4 0.0013 0.0087 0.006
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0174 0.0215
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0014 0.0106 0.0104
Leishmania major hypothetical protein, conserved 0.0022 0.029 0.165
Schistosoma mansoni sphingosine kinase A B 0.0305 0.6922 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0013 0.0087 0.006
Echinococcus granulosus GTP binding nuclear protein Ran 0.0013 0.0076 0.0049
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0174 0.2585
Schistosoma mansoni aldehyde dehydrogenase 0.0079 0.1622 0.2313
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0093 0.0067
Leishmania major sphingosine kinase A, B, putative 0.0012 0.0054 0.0171
Schistosoma mansoni hypothetical protein 0.0024 0.0333 0.0445
Echinococcus granulosus muscleblind protein 0.0436 1 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0014 0.0093 0.0116
Echinococcus multilocularis smad 0.0013 0.0087 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0174 0.2585
Plasmodium falciparum diacylglycerol kinase, putative 0.0012 0.0054 0.0696
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.029 0.4599
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0054 0.0039
Schistosoma mansoni hypothetical protein 0.0024 0.0333 0.0445
Loa Loa (eye worm) hypothetical protein 0.0022 0.029 0.0277
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0064 0.128 0.1257
Echinococcus granulosus ceramide kinase 0.0012 0.0054 0.0027
Loa Loa (eye worm) hypothetical protein 0.0017 0.0174 0.0162
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0022 0.029 0.0418
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0012 0.0054 0.0027
Trypanosoma cruzi importin beta-1 subunit, putative 0.0014 0.0106 0.1394
Trypanosoma brucei Sphingosine kinase 0.0012 0.0054 0.0476
Schistosoma mansoni DNA polymerase eta 0.0017 0.0174 0.0215
Leishmania major hypothetical protein, conserved 0.0012 0.0054 0.0171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0093 0.0135
Schistosoma mansoni aldehyde dehydrogenase 0.0079 0.1622 0.2313
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0054 0.0039
Trichomonas vaginalis importin beta-1, putative 0.0014 0.0106 0.0104
Loa Loa (eye worm) latrophilin receptor protein 2 0.0024 0.0333 0.0321
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0093 0.0116
Brugia malayi Eye-specific diacylglycerol kinase 0.0012 0.0054 0.0027
Mycobacterium ulcerans beta-lactamase 0.0022 0.029 0.04
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0174 0.0252
Mycobacterium ulcerans aldehyde dehydrogenase 0.0079 0.1622 0.2328
Brugia malayi MH1 domain containing protein 0.0013 0.0087 0.006
Echinococcus multilocularis ceramide kinase 0.0012 0.0054 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0174 0.2585
Loa Loa (eye worm) hypothetical protein 0.0022 0.029 0.0277
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0174 0.0215
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0022 0.029 0.04
Schistosoma mansoni hypothetical protein 0.0103 0.2196 0.3146
Trypanosoma cruzi DNA polymerase kappa, putative 0.0017 0.0174 0.2585
Brugia malayi RNA, U transporter 1 0.005 0.0936 0.0912
Entamoeba histolytica acyl-CoA synthetase, putative 0.0014 0.0093 0.0097
Onchocerca volvulus 0.0057 0.1105 0.1377
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0174 0.2585
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0054 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0174 0.2585
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0079 0.1622 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0014 0.0093 0.0135
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0093 0.0067
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0054 0.0476
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0012 0.0054 0.0036
Loa Loa (eye worm) hypothetical protein 0.0278 0.6294 0.6289
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0051 0.0421
Brugia malayi MH2 domain containing protein 0.0195 0.4344 0.4329
Loa Loa (eye worm) transcription factor SMAD2 0.0195 0.4344 0.4336
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0075 0.1539 0.1528
Plasmodium falciparum diacylglycerol kinase, putative 0.0012 0.0054 0.0696
Brugia malayi hypothetical protein 0.0035 0.0599 0.0574
Entamoeba histolytica acyl-coA synthetase, putative 0.0014 0.0093 0.0097
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0054 0.0476
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.128 0.1818
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0079 0.1622 0.2343
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.1105 0.1081
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0011 0.0027 0.002
Brugia malayi Latrophilin receptor protein 2 0.0024 0.0333 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0054 0.0036
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0174 0.0148
Loa Loa (eye worm) hypothetical protein 0.0075 0.1539 0.1528
Echinococcus granulosus survival motor neuron protein 1 0.0278 0.6294 0.6284
Echinococcus multilocularis sphingosine kinase 1 0.0305 0.6922 0.6914
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0012 0.0054 0.0027
Leishmania major diacylglycerol kinase, putative 0.0012 0.0054 0.0171
Echinococcus granulosus importin subunit beta 1 0.0017 0.0184 0.0157
Leishmania major diacylglycerol kinase-like protein 0.0012 0.0054 0.0171
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0024 0.0333 0.0308
Trichomonas vaginalis bmru protein, putative 0.0012 0.0054 0.0036
Leishmania major DNA polymerase kappa, putative 0.0017 0.0174 0.0928
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0012 0.0054 0.0476
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0024 0.0333 0.0308
Echinococcus granulosus Smad4 0.0013 0.0087 0.006
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0174 0.0148
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0013 0.0076 0.1072
Leishmania major 4-coumarate:coa ligase-like protein 0.0014 0.0093 0.0419
Echinococcus granulosus sphingosine kinase 1 0.0305 0.6922 0.6914
Mycobacterium tuberculosis Possible penicillin-binding protein 0.014 0.3061 0.4422
Loa Loa (eye worm) hypothetical protein 0.0436 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 380.5 uM Inhibition of glycation of bovine serum albumin assessed as advanced glycated end product measured after 7 days by spectrofluorimeter in presence of glucose anhydrous ChEMBL. 23314045

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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