Detailed information for compound 1743294

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 429.321 | Formula: C12H17N5NaO7PS
  • H donors: 5 H acceptors: 8 LogP: -2.34 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSc1nc2c(n1[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(O)[O-])ncnc2N.[Na+]
  • InChi: 1S/C12H18N5O7PS.Na/c1-2-26-12-16-6-9(13)14-4-15-10(6)17(12)11-8(19)7(18)5(24-11)3-23-25(20,21)22;/h4-5,7-8,11,18-19H,2-3H2,1H3,(H2,13,14,15)(H2,20,21,22);/q;+1/p-1/t5-,7-,8-,11-;/m1./s1
  • InChiKey: YZEZVAMCILCLBQ-YCSZXMBFSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tubulin alpha 1C chain 0.0009 0.0644 0.0644
Toxoplasma gondii beta tubulin 0.0024 0.2433 0.2433
Toxoplasma gondii alpha-tubulin I, putative 0.0009 0.0644 0.0644
Schistosoma mansoni tubulin subunit beta 0.0024 0.2433 0.2433
Plasmodium falciparum alpha tubulin 1 0.0009 0.0644 0.0644
Brugia malayi Tubulin alpha-2 chain 0.0009 0.0644 0.0644
Echinococcus granulosus peroxisome assembly protein 26 0.0009 0.0644 0.0644
Echinococcus multilocularis short transient receptor potential channel 6 0.0005 0.0087 0.0087
Trichomonas vaginalis tubulin beta chain, putative 0.0024 0.2433 0.2433
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0011 0.0808 0.0808
Leishmania major methionine aminopeptidase 2, putative 0.0086 1 1
Brugia malayi Tubulin alpha chain 0.0009 0.0644 0.0644
Echinococcus granulosus Tubulin alpha 1 chain 0.0009 0.0644 0.0644
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.2433 0.2433
Treponema pallidum aminopeptidase P 0.0011 0.0808 1
Leishmania major alpha tubulin 0.0009 0.0644 0.0644
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0011 0.0808 0.0808
Trichomonas vaginalis tubulin epsilon chain, putative 0.0009 0.0644 0.0644
Leishmania major epsilon tubulin, putative 0.0009 0.0644 0.0644
Echinococcus granulosus tubulin subunit beta 0.0024 0.2433 0.2433
Echinococcus granulosus tubulin alpha 1C chain 0.0009 0.0644 0.0644
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0011 0.0808 0.0808
Entamoeba histolytica hypothetical protein, conserved 0.0011 0.0808 0.0175
Echinococcus granulosus tubulin beta 4A class IVa 0.0024 0.2433 0.2433
Brugia malayi olfactory channel protein osm-9 0.0005 0.0087 0.0087
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0808 0.0808
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0011 0.0808 0.0668
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Echinococcus multilocularis methionine aminopeptidase, type I 0.0011 0.0808 0.0808
Plasmodium falciparum alpha tubulin 2 0.0009 0.0644 0.0644
Echinococcus multilocularis beta tubulin 0.0024 0.2433 0.2433
Loa Loa (eye worm) tubulin beta-1 chain 0.0024 0.2433 0.2433
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0086 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0009 0.0644 0.0644
Trichomonas vaginalis tubulin alpha chain, putative 0.0005 0.015 0.015
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.2433 0.2433
Echinococcus granulosus transient receptor potential cation channel 0.0005 0.0087 0.0087
Plasmodium vivax methionine aminopeptidase 2, putative 0.0086 1 1
Echinococcus granulosus alpha tubulin 0.0009 0.0644 0.0644
Trypanosoma brucei alpha tubulin 0.0009 0.0644 0.0644
Plasmodium vivax tubulin beta chain, putative 0.0024 0.2433 0.2433
Plasmodium vivax tubulin epsilon chain, putative 0.0009 0.0644 0.0644
Schistosoma mansoni tubulin subunit alpha 0.0009 0.0644 0.0644
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0011 0.0808 0.0808
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0011 0.0808 0.0808
Echinococcus multilocularis hypothetical protein 0.0009 0.0644 0.0644
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0086 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0009 0.0644 0.0644
Schistosoma mansoni alpha tubulin 0.0009 0.0644 0.0644
Trypanosoma brucei alpha tubulin 0.0009 0.0644 0.0644
Echinococcus multilocularis tubulin beta 1 chain 0.0024 0.2433 0.2433
Echinococcus granulosus tubulin alpha chain 0.0009 0.0644 0.0644
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.2433 0.2433
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0011 0.0808 1
Brugia malayi Methionine aminopeptidase protein type I 0.0011 0.0808 0.0808
Trichomonas vaginalis tubulin epsilon chain, putative 0.0024 0.2433 0.2433
Echinococcus multilocularis methionyl aminopeptidase 2 0.0086 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0808 0.0808
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0011 0.0808 0.0808
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0011 0.0808 0.0808
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0011 0.0808 1
Brugia malayi tubulin alpha-2 chain 0.0009 0.0644 0.0644
Trypanosoma brucei epsilon tubulin 0.0009 0.0644 0.0644
Trypanosoma brucei beta tubulin 0.0024 0.2433 0.2433
Trichomonas vaginalis tubulin alpha chain, putative 0.0005 0.015 0.015
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0011 0.0808 1
Treponema pallidum methionine aminopeptidase (map) 0.0011 0.0808 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0086 1 1
Leishmania major gamma-tubulin 0.0009 0.0644 0.0644
Leishmania major transcription factor-like protein 0.0011 0.0808 0.0808
Trypanosoma brucei beta tubulin 0.0024 0.2433 0.2433
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0086 1 1
Trypanosoma cruzi epsilon tubulin, putative 0.0009 0.0644 0.0644
Giardia lamblia Xaa-Pro dipeptidase 0.0011 0.0808 0.0808
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0011 0.0808 0.0808
Trichomonas vaginalis tubulin epsilon chain, putative 0.0024 0.2433 0.2433
Loa Loa (eye worm) hypothetical protein 0.0009 0.0644 0.0644
Trypanosoma brucei alpha tubulin 0.0009 0.0644 0.0644
Schistosoma mansoni tubulin subunit beta 0.0024 0.2433 0.2433
Giardia lamblia Beta tubulin 0.0024 0.2433 0.2433
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0808 0.0808
Schistosoma mansoni tubulin subunit beta 0.0024 0.2433 0.2433
Toxoplasma gondii beta-tubulin, putative 0.0024 0.2433 0.2433
Toxoplasma gondii methionine aminopeptidase 0.0011 0.0808 0.0808
Echinococcus granulosus beta tubulin 0.0024 0.2433 0.2433
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0011 0.0808 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0009 0.0644 0.0644
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0011 0.0808 0.0808
Echinococcus multilocularis tubulin alpha chain 0.0009 0.0644 0.0644
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0011 0.0808 0.0808
Trypanosoma brucei epsilon tubulin 0.0009 0.0644 0.0644
Trypanosoma brucei alpha tubulin, putative 0.0005 0.015 0.015
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0011 0.0808 0.0808
Trichomonas vaginalis tubulin gamma chain, putative 0.0009 0.0644 0.0644
Entamoeba histolytica aminopeptidase, putative 0.0011 0.0808 0.0175
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0011 0.0808 0.0808
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0011 0.0808 1
Leishmania major alpha tubulin 0.0009 0.0644 0.0644
Loa Loa (eye worm) tubulin gamma chain 0.0009 0.0644 0.0644
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0011 0.0808 1
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0011 0.0808 0.0808
Echinococcus granulosus tubulin alpha chain 0.0009 0.0644 0.0644
Toxoplasma gondii beta-1 tubulin, putative 0.0024 0.2433 0.2433
Echinococcus multilocularis tubulin alpha 3 chain 0.0009 0.0644 0.0644
Toxoplasma gondii creatinase domain-containing protein 0.0011 0.0808 0.0808
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0011 0.0808 0.0808
Schistosoma mansoni tubulin subunit epsilon 0.0009 0.0644 0.0644
Giardia lamblia Alpha-tubulin 0.0009 0.0644 0.0644
Leishmania major hypothetical protein, conserved 0.0011 0.0808 0.0808
Onchocerca volvulus Dipeptidase C homolog 0.0011 0.0808 0.0668
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0011 0.0808 0.0808
Schistosoma mansoni transient receptor potential channel 0.0005 0.0087 0.0087
Echinococcus granulosus tubulin beta 1 chain 0.0024 0.2433 0.2433
Echinococcus granulosus xaa Pro dipeptidase 0.0011 0.0808 0.0808
Brugia malayi Tubulin beta-1 chain 0.0024 0.2433 0.2433
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0808 0.0808
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Loa Loa (eye worm) initiation factor 2-associated protein 0.0086 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0086 1 1
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Plasmodium vivax peptidase, putative 0.0011 0.0808 0.0808
Echinococcus granulosus xaa pro aminopeptidase 0.0011 0.0808 0.0808
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0011 0.0808 0.0808
Trypanosoma brucei Metallopeptidase family M24, putative 0.0011 0.0808 0.0808
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0011 0.0808 0.0808
Leishmania major alpha tubulin 0.0009 0.0644 0.0644
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0011 0.0808 0.0808
Loa Loa (eye worm) BEN-1 protein 0.0024 0.2433 0.2433
Echinococcus granulosus tubulin alpha chain 0.0009 0.0644 0.0644
Echinococcus multilocularis xaa pro aminopeptidase 0.0011 0.0808 0.0808
Trypanosoma brucei tubulin gamma chain 0.0009 0.0644 0.0644
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0011 0.0808 0.0808
Trichomonas vaginalis tubulin beta chain, putative 0.0009 0.0644 0.0644
Leishmania major alpha tubulin 0.0009 0.0644 0.0644
Loa Loa (eye worm) DNA-binding protein 0.0011 0.0808 0.0808
Giardia lamblia Xaa-Pro dipeptidase 0.0011 0.0808 0.0808
Echinococcus multilocularis Tubulin alpha 1 chain 0.0009 0.0644 0.0644
Leishmania major alpha tubulin 0.0009 0.0644 0.0644
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0011 0.0808 1
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0011 0.0808 0.0808
Trypanosoma cruzi aminopeptidase P1, putative 0.0011 0.0808 0.0808
Loa Loa (eye worm) methionine aminopeptidase type I 0.0011 0.0808 0.0808
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.2433 0.2433
Leishmania major alpha tubulin 0.0009 0.0644 0.0644
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0011 0.0808 0.0808
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0086 1 1
Plasmodium vivax FACT complex subunit SPT16, putative 0.0011 0.0808 0.0808
Trypanosoma cruzi beta tubulin, putative 0.0024 0.2433 0.2433
Echinococcus multilocularis tubulin gamma 1 chain 0.0009 0.0644 0.0644
Echinococcus granulosus Tubulin alpha 1 chain 0.0009 0.0644 0.0644
Giardia lamblia Beta tubulin 0.0024 0.2433 0.2433
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0086 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0009 0.0644 0.0644
Echinococcus multilocularis transient receptor potential cation channel 0.0005 0.0087 0.0087
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Loa Loa (eye worm) tubulin beta chain 0.0024 0.2433 0.2433
Plasmodium vivax tubulin alpha chain, putative 0.0009 0.0644 0.0644
Plasmodium falciparum aminopeptidase P 0.0011 0.0808 0.0808
Trypanosoma cruzi tubulin gamma chain 0.0009 0.0644 0.0644
Plasmodium falciparum tubulin epsilon chain, putative 0.0009 0.0644 0.0644
Trichomonas vaginalis tubulin beta chain, putative 0.0005 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0808 0.0808
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0011 0.0808 0.0808
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0011 0.0808 0.0808
Brugia malayi Tubulin gamma chain 0.0009 0.0644 0.0644
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0009 0.0644 0.0644
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0011 0.0808 0.0808
Loa Loa (eye worm) alpha-tubulin 0.0009 0.0644 0.0644
Trichomonas vaginalis tubulin gamma chain, putative 0.0009 0.0644 0.0644
Echinococcus multilocularis tubulin alpha chain 0.0009 0.0644 0.0644
Brugia malayi Tubulin beta chain 0.0005 0.015 0.015
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0011 0.0808 0.0808
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0808 0.0808
Trypanosoma cruzi epsilon tubulin, putative 0.0009 0.0644 0.0644
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0086 1 1
Leishmania major alpha tubulin 0.0009 0.0644 0.0644
Brugia malayi metallopeptidase family M24 containing protein 0.0011 0.0808 0.0808
Brugia malayi metallopeptidase family M24 containing protein 0.0011 0.0808 0.0808
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.2433 0.2433
Loa Loa (eye worm) tubulin alpha 2 0.0005 0.015 0.015
Loa Loa (eye worm) BEN-1 protein 0.0024 0.2433 0.2433
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0086 1 1
Echinococcus multilocularis tubulin alpha chain 0.0009 0.0644 0.0644
Echinococcus multilocularis tubulin alpha 0.0009 0.0644 0.0644
Mycobacterium ulcerans aminopeptidase 0.0011 0.0808 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0011 0.0808 0.0808
Trichomonas vaginalis tubulin alpha chain, putative 0.0005 0.015 0.015
Toxoplasma gondii transcriptional elongation factor FACT140 0.0011 0.0808 0.0808
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0011 0.0808 0.0808
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0005 0.015 0.015
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0011 0.0808 0.0808
Trichomonas vaginalis tubulin beta chain, putative 0.0009 0.0644 0.0644
Echinococcus granulosus FACT complex subunit SPT16 0.0011 0.0808 0.0808
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0011 0.0808 0.0808
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.2433 0.2433
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0011 0.0808 0.0808
Schistosoma mansoni tubulin subunit alpha 0.0009 0.0644 0.0644
Toxoplasma gondii peptidase D, putative 0.0011 0.0808 0.0808
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0011 0.0808 0.0808
Trypanosoma brucei beta tubulin 0.0009 0.0644 0.0644
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0011 0.0808 1
Trypanosoma brucei beta tubulin 0.0024 0.2433 0.2433
Echinococcus granulosus Proliferation associated protein 2G4 0.0011 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.0011 0.0808 0.0808
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.2433 0.2433
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Echinococcus granulosus tubulin alpha 3 chain 0.0009 0.0644 0.0644
Entamoeba histolytica tubulin family protein 0.0024 0.2433 0.1912
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Plasmodium falciparum tubulin gamma chain 0.0009 0.0644 0.0644
Echinococcus granulosus tubulin subunit TubB 0.0009 0.0644 0.0644
Schistosoma mansoni alpha tubulin 0.0009 0.0644 0.0644
Echinococcus multilocularis FACT complex subunit SPT16 0.0011 0.0808 0.0808
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0011 0.0808 0.0808
Trichomonas vaginalis tubulin beta chain, putative 0.0009 0.0644 0.0644
Echinococcus multilocularis xaa Pro dipeptidase 0.0011 0.0808 0.0808
Brugia malayi tubulin alpha chain - mouse 0.0009 0.0644 0.0644
Leishmania major alpha tubulin 0.0009 0.0644 0.0644
Plasmodium vivax tubulin alpha chain, putative 0.0009 0.0644 0.0644
Trichomonas vaginalis tubulin gamma chain, putative 0.0024 0.2433 0.2433
Trypanosoma brucei alpha tubulin 0.0009 0.0644 0.0644
Chlamydia trachomatis methionine aminopeptidase 0.0011 0.0808 0.5
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Trypanosoma cruzi aminopeptidase P, putative 0.0011 0.0808 0.0808
Echinococcus granulosus tubulin alpha chain 0.0009 0.0644 0.0644
Entamoeba histolytica tubulin family protein 0.0024 0.2433 0.1912
Loa Loa (eye worm) hypothetical protein 0.0005 0.015 0.015
Trichomonas vaginalis tubulin alpha chain, putative 0.0024 0.2433 0.2433
Entamoeba histolytica methionine aminopeptidase, putative 0.0086 1 1
Echinococcus granulosus tubulin alpha 0.0009 0.0644 0.0644
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0011 0.0808 1
Echinococcus multilocularis tubulin subunit beta 0.0024 0.2433 0.2433
Schistosoma mansoni tubulin subunit beta 0.0024 0.2433 0.2433
Giardia lamblia Beta tubulin 0.0024 0.2433 0.2433
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0011 0.0808 0.0808
Schistosoma mansoni tubulin subunit beta 0.0024 0.2433 0.2433
Echinococcus granulosus tubulin alpha 3 chain 0.0009 0.0644 0.0644
Loa Loa (eye worm) tubulin alpha-2 chain 0.0009 0.0644 0.0644
Mycobacterium ulcerans methionine aminopeptidase 0.0011 0.0808 1
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.2433 0.2433
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0011 0.0808 0.0808
Loa Loa (eye worm) tubulin beta-4 chain 0.0024 0.2433 0.2433
Echinococcus multilocularis tubulin alpha 1C chain 0.0009 0.0644 0.0644
Brugia malayi alpha-tubulin 0.0009 0.0644 0.0644
Mycobacterium ulcerans dipeptidase PepE 0.0011 0.0808 1
Echinococcus multilocularis xaa Pro dipeptidase 0.0011 0.0808 0.0808
Trichomonas vaginalis tubulin beta chain, putative 0.0009 0.0644 0.0644
Echinococcus multilocularis tubulin alpha 1C chain 0.0009 0.0644 0.0644
Trichomonas vaginalis tubulin, putative 0.0005 0.015 0.015
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Toxoplasma gondii methionine aminopeptidase 0.0011 0.0808 0.0808
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0011 0.0808 0.0808
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0011 0.0808 0.0808
Trypanosoma brucei epsilon tubulin 0.0009 0.0644 0.0644
Giardia lamblia Gamma tubulin 0.0009 0.0644 0.0644
Echinococcus multilocularis tubulin alpha chain 0.0009 0.0644 0.0644
Mycobacterium tuberculosis Dipeptidase PepE 0.0011 0.0808 1
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0011 0.0808 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0011 0.0808 0.0808
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0011 0.0808 0.0808
Schistosoma mansoni alpha tubulin 0.0009 0.0644 0.0644
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0011 0.0808 0.0808
Echinococcus granulosus tubulin alpha chain 0.0009 0.0644 0.0644
Loa Loa (eye worm) tubulin alpha chain 0.0009 0.0644 0.0644
Echinococcus multilocularis peroxisome assembly protein 26 0.0009 0.0644 0.0644
Plasmodium vivax tubulin gamma chain, putative 0.0009 0.0644 0.0644
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Brugia malayi Tubulin alpha-2 chain 0.0009 0.0644 0.0644
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0024 0.2433 0.2433
Echinococcus granulosus tubulin epsilon chain 0.0009 0.0644 0.0644
Echinococcus multilocularis tubulin epsilon chain 0.0009 0.0644 0.0644
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0808 0.0808
Entamoeba histolytica peptidase, putative 0.0011 0.0808 0.0175
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.2433 0.2433
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Brugia malayi metallopeptidase family M24 containing protein 0.0011 0.0808 0.0808
Plasmodium falciparum methionine aminopeptidase 2 0.0086 1 1
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0011 0.0808 0.0808
Echinococcus multilocularis tubulin subunit TubB 0.0009 0.0644 0.0644
Leishmania major alpha tubulin 0.0009 0.0644 0.0644
Leishmania major alpha tubulin 0.0009 0.0644 0.0644
Loa Loa (eye worm) hypothetical protein 0.0011 0.0808 0.0808
Loa Loa (eye worm) alpha-tubulin 0.0009 0.0644 0.0644
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0011 0.0808 0.0808
Schistosoma mansoni tubulin subunit beta 0.0024 0.2433 0.2433
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0005 0.015 0.015
Toxoplasma gondii alpha tubulin TUBA1 0.0009 0.0644 0.0644
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0011 0.0808 0.0808
Trypanosoma brucei methionine aminopeptidase, putative 0.0011 0.0808 0.0808
Chlamydia trachomatis aminopeptidase P 0.0011 0.0808 0.5
Loa Loa (eye worm) beta-tubulin 0.0024 0.2433 0.2433
Schistosoma mansoni tubulin subunit gamma 0.0009 0.0644 0.0644
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0808 0.0808
Trichomonas vaginalis tubulin, putative 0.0024 0.2433 0.2433
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Echinococcus granulosus beta tubulin 0.0024 0.2433 0.2433
Trichomonas vaginalis tubulin epsilon chain, putative 0.0009 0.0644 0.0644
Leishmania major alpha tubulin 0.0009 0.0644 0.0644
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0808 0.0808
Loa Loa (eye worm) tubulin beta-2A chain 0.0024 0.2433 0.2433
Echinococcus multilocularis beta tubulin 0.0024 0.2433 0.2433
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0011 0.0808 0.0808
Echinococcus granulosus tubulin gamma 1 chain 0.0009 0.0644 0.0644
Trypanosoma brucei beta tubulin 0.0024 0.2433 0.2433
Echinococcus granulosus short transient receptor potential channel 6 0.0005 0.0087 0.0087
Mycobacterium ulcerans dipeptidase 0.0011 0.0808 1
Echinococcus multilocularis Proliferation associated protein 2G4 0.0011 0.0808 0.0808
Echinococcus granulosus methionyl aminopeptidase 2 0.0086 1 1
Trichomonas vaginalis tubulin, putative 0.0005 0.015 0.015
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0011 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.0005 0.0087 0.0087
Leishmania major alpha tubulin 0.0009 0.0644 0.0644
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0086 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0009 0.0644 0.0644
Giardia lamblia Methionine aminopeptidase 0.0086 1 1
Echinococcus multilocularis tubulin alpha chain 0.0009 0.0644 0.0644
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0005 0.015 0.015
Trichomonas vaginalis tubulin alpha chain, putative 0.0009 0.0644 0.0644
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0011 0.0808 0.0808
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0011 0.0808 0.0808
Loa Loa (eye worm) tubulin alpha chain 0.0009 0.0644 0.0644
Loa Loa (eye worm) tubulin alpha 2 0.0005 0.015 0.015
Trichomonas vaginalis tubulin beta chain, putative 0.0009 0.0644 0.0644
Brugia malayi beta-tubulin, identical 0.0024 0.2433 0.2433
Echinococcus multilocularis transient receptor potential cation channel 0.0005 0.0087 0.0087
Trypanosoma cruzi alpha tubulin, putative 0.0009 0.0644 0.0644
Schistosoma mansoni tubulin subunit alpha 0.0009 0.0644 0.0644
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0086 1 1
Echinococcus granulosus methionine aminopeptidase type I 0.0011 0.0808 0.0808
Echinococcus multilocularis Tubulin alpha 1 chain 0.0009 0.0644 0.0644
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.2433 0.2433
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0011 0.0808 0.0808
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0011 0.0808 0.0808
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0011 0.0808 0.0175
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Plasmodium falciparum tubulin beta chain 0.0024 0.2433 0.2433
Leishmania major beta tubulin 0.0024 0.2433 0.2433
Giardia lamblia Alpha-tubulin 0.0009 0.0644 0.0644
Onchocerca volvulus 0.0011 0.0808 0.0668
Echinococcus granulosus xaa Pro dipeptidase 0.0011 0.0808 0.0808
Schistosoma mansoni peptidase 0.0011 0.0808 0.0808

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 15 mM Inhibitory activity against rat Adenylate kinase M isoenzyme was determined in the presence of ATP, non competitive inhibition ChEMBL. 6292418
Ki (binding) = 21 mM Non competitive binding inhibition constant(Ki) of rat adenylate kinase (AK III) isozymes was determined ChEMBL. 6284937
Ki (binding) = 21 mM Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, non competitive inhibition ChEMBL. 6292418
Ki (binding) = 24 mM Non competitive binding inhibition of rat adenylate kinase IIl was determined ChEMBL. 6284937
Vmax (binding) = 0 % Inhibitory constant of rat adenylate kinase (AK II) isozymes expressed as relative maximal velocity ChEMBL. 6284937

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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