Detailed information for compound 1745623

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1327.02 | Formula: C50H72I2N16O11
  • H donors: 13 H acceptors: 11 LogP: -4.16 Rotable bonds: 35
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCCN=C(N)N)Cc1cc(I)c(c(c1)I)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)N
  • InChi: 1S/C50H72I2N16O11/c51-29-21-28(22-30(52)40(29)54)24-34(42(72)63-32(48(78)79)12-5-17-60-50(57)58)64-44(74)37-14-7-18-66(37)46(76)35(26-69)65-41(71)33(23-27-9-2-1-3-10-27)62-39(70)25-61-43(73)36-13-6-19-67(36)47(77)38-15-8-20-68(38)45(75)31(53)11-4-16-59-49(55)56/h1-3,9-10,21-22,31-38,69H,4-8,11-20,23-26,53-54H2,(H,61,73)(H,62,70)(H,63,72)(H,64,74)(H,65,71)(H,78,79)(H4,55,56,59)(H4,57,58,60)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1
  • InChiKey: KDANGSAIDSRONO-QSVFAHTRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0061 0.0067
Echinococcus multilocularis g protein coupled receptor 0.0162 0.0951 0.1047
Onchocerca volvulus 0.0726 0.5086 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0436 0.099
Brugia malayi larval opioid receptor 0.0162 0.0951 0.2142
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0061 0.0138
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0219 0.1368 0.3102
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0162 0.0951 0.2142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0275 0.054
Loa Loa (eye worm) phosphatidylinositol 3 0.0117 0.062 0.1396
Loa Loa (eye worm) hypothetical protein 0.0055 0.0169 0.038
Treponema pallidum sodium- and chloride- dependent transporter 0.0237 0.1506 1
Echinococcus granulosus serine protein kinase ATM 0.0049 0.0128 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0489 0.0962
Echinococcus granulosus neuropeptide receptor 0.0162 0.0951 0.1047
Brugia malayi hypothetical protein 0.0162 0.0951 0.2142
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0407 0.0801
Echinococcus granulosus neuropeptide Y receptor 0.0162 0.0951 0.1047
Brugia malayi Pre-SET motif family protein 0.0638 0.4441 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0162 0.0951 0.2157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0472 0.0929
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0538 0.1057
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0173 0.0388
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0554 0.109
Echinococcus granulosus g protein coupled receptor 0.0162 0.0951 0.1047
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0088 0.0407 0.0448
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0162 0.0951 0.1047
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0061 0.0067
Schistosoma mansoni opsin-like receptor 0.0162 0.0951 0.2157
Schistosoma mansoni neuropeptide F-like receptor 0.0162 0.0951 0.2157
Plasmodium falciparum phd finger protein, putative 0.0064 0.0238 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0162 0.0951 0.2157
Echinococcus multilocularis fmrfamide receptor 0.0162 0.0951 0.1047
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0061 0.0067
Schistosoma mansoni neuropeptide receptor 0.0162 0.0951 0.2157
Loa Loa (eye worm) hypothetical protein 0.0102 0.0514 0.1157
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0117 0.062 0.4451
Schistosoma mansoni alpha-1 adrenergic receptor 0.0162 0.0951 0.2157
Echinococcus granulosus rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.004 0.0061 0.0067
Echinococcus multilocularis rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Echinococcus granulosus tumor protein p63 0.1271 0.9084 1
Loa Loa (eye worm) G-protein coupled receptor 0.0162 0.0951 0.2142
Echinococcus granulosus 7TM GPCR rhodopsin 0.0162 0.0951 0.1047
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0088 0.0407 0.2875
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0219 0.1368 0.3102
Plasmodium vivax SET domain protein, putative 0.0091 0.0436 0.2871
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0117 0.062 0.0682
Echinococcus granulosus serotonin transporter 0.0237 0.1506 0.1658
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.004 0.0061 0.0138
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0144 0.0573
Loa Loa (eye worm) neuropeptide F receptor 0.0162 0.0951 0.2142
Schistosoma mansoni neuropeptide f receptor 76f 0.0162 0.0951 0.2157
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0109 0.0247
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0088 0.0407 0.1649
Schistosoma mansoni neuropeptide receptor 0.0162 0.0951 0.2157
Brugia malayi G-protein coupled receptor 0.0162 0.0951 0.2142
Onchocerca volvulus 0.0162 0.0951 0.1771
Loa Loa (eye worm) hypothetical protein 0.0237 0.1506 0.3391
Onchocerca volvulus 0.0162 0.0951 0.1771
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0004 0.0008
Echinococcus granulosus expressed protein 0.0038 0.0045 0.005
Echinococcus granulosus tm gpcr rhodopsin 0.0162 0.0951 0.1047
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0061 0.0139
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0061 0.0067
Brugia malayi hypothetical protein 0.0111 0.0579 0.1304
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0049 0.0128 0.0505
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0144 0.4682
Onchocerca volvulus 0.0162 0.0951 0.1771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0078 0.034 0.0669
Entamoeba histolytica hypothetical protein 0.0111 0.0579 0.1887
Brugia malayi hypothetical protein 0.0168 0.0998 0.2249
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0151 0.0871 0.1713
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.0338 0.0766
Onchocerca volvulus 0.0162 0.0951 0.1771
Echinococcus multilocularis G-protein coupled receptor, putative 0.0162 0.0951 0.1047
Loa Loa (eye worm) hypothetical protein 0.014 0.0793 0.1786
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0162 0.0951 0.1047
Loa Loa (eye worm) hypothetical protein 0.004 0.0061 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0162 0.0951 0.2157
Schistosoma mansoni ferritin 0.0038 0.0045 0.0102
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0117 0.062 0.1405
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0088 0.0407 0.2875
Echinococcus granulosus rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Loa Loa (eye worm) neuropeptide F receptor 0.0162 0.0951 0.2142
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0162 0.0951 0.2142
Echinococcus multilocularis microtubule associated protein 2 0.0634 0.4409 0.4854
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0117 0.062 0.1396
Brugia malayi MH2 domain containing protein 0.0234 0.1482 0.3338
Loa Loa (eye worm) hypothetical protein 0.004 0.0061 0.0138
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0173 0.0388
Schistosoma mansoni amine GPCR 0.0162 0.0951 0.2157
Echinococcus multilocularis neuropeptide receptor 0.0162 0.0951 0.1047
Brugia malayi Dopamine receptor 0.0162 0.0951 0.2142
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0061 0.0139
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.004 0.0061 0.0067
Brugia malayi G-protein coupled receptor 0.0162 0.0951 0.2142
Echinococcus multilocularis dro:myosuppressin receptor 0.0162 0.0951 0.1047
Brugia malayi putative neuropeptide receptor 0.0162 0.0951 0.2142
Echinococcus granulosus peregrin 0.0064 0.0238 0.0262
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0162 0.0951 0.2142
Loa Loa (eye worm) jmjC domain-containing protein 0.0078 0.0338 0.0761
Schistosoma mansoni biogenic amine (5HT) receptor 0.0162 0.0951 0.2157
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0117 0.062 0.2519
Echinococcus multilocularis neuropeptide receptor 0.0162 0.0951 0.1047
Trypanosoma cruzi hypothetical protein, conserved 0.0219 0.1368 0.5579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0473 0.0929
Toxoplasma gondii PHD-finger domain-containing protein 0.0064 0.0238 0.1356
Echinococcus multilocularis sex peptide receptor 0.0162 0.0951 0.1047
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0038 0.0045 0.5
Schistosoma mansoni hypothetical protein 0.0038 0.0046 0.0103
Echinococcus granulosus g protein coupled receptor 0.0162 0.0951 0.1047
Schistosoma mansoni cellular tumor antigen P53 0.0186 0.113 0.2562
Onchocerca volvulus 0.0219 0.1368 0.26
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0219 0.1368 0.308
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Loa Loa (eye worm) hypothetical protein 0.0219 0.1368 0.308
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0162 0.0951 0.1771
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0162 0.0951 0.2157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0436 0.099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0407 0.0801
Schistosoma mansoni hypothetical protein 0.0111 0.0579 0.1313
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.1482 0.3338
Echinococcus granulosus allatostatin A receptor 0.0162 0.0951 0.1047
Brugia malayi beta-lactamase 0.0219 0.1368 0.308
Echinococcus granulosus biogenic amine 5HT receptor 0.0162 0.0951 0.1047
Loa Loa (eye worm) serotonin transporter b 0.0237 0.1506 0.3391
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0219 0.1368 1
Giardia lamblia GTOR 0.0117 0.062 0.1672
Loa Loa (eye worm) norepinephrine transporter 0.0237 0.1506 0.3391
Echinococcus granulosus rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Loa Loa (eye worm) hypothetical protein 0.004 0.0061 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0169 0.0332
Brugia malayi hypothetical protein 0.0102 0.0514 0.1157
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0151 0.0871 0.1713
Echinococcus multilocularis neuropeptide Y receptor 0.0162 0.0951 0.1047
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Schistosoma mansoni fkbp-rapamycin associated protein 0.0049 0.0128 0.0289
Loa Loa (eye worm) solute carrier family 6 member 4 0.0237 0.1506 0.3391
Echinococcus multilocularis g-protein coupled receptor 0.0162 0.0951 0.1047
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0128 0.0287
Echinococcus multilocularis rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Schistosoma mansoni neuropeptide receptor 0.0162 0.0951 0.2157
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Entamoeba histolytica hypothetical protein 0.0111 0.0579 0.1887
Schistosoma mansoni myosin xvIII 0.0162 0.0951 0.2157
Brugia malayi Dopamine receptor protein 1 0.0162 0.0951 0.2142
Brugia malayi neuropeptide F receptor 0.0162 0.0951 0.2142
Plasmodium vivax hypothetical protein, conserved 0.0219 0.1368 1
Brugia malayi hypothetical protein 0.0162 0.0951 0.2142
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0117 0.062 0.2058
Brugia malayi sulfakinin receptor protein 0.0162 0.0951 0.2142
Echinococcus granulosus PHD finger protein rhinoceros 0.0064 0.0238 0.0262
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Schistosoma mansoni amine GPCR 0.0162 0.0951 0.2157
Echinococcus multilocularis serine protein kinase ATM 0.0049 0.0128 0.014
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Echinococcus granulosus beta LACTamase domain containing family member 0.0219 0.1368 0.1506
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Mycobacterium tuberculosis Probable esterase LipL 0.0219 0.1368 0.1329
Loa Loa (eye worm) hypothetical protein 0.0038 0.0046 0.0103
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.1049 0.7455 0.8207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0117 0.062 0.1218
Schistosoma mansoni ferritin light chain 0.0038 0.0045 0.0102
Brugia malayi jmjC domain containing protein 0.0211 0.1313 0.2958
Trichomonas vaginalis D-aminoacylase, putative 0.0219 0.1368 0.2689
Brugia malayi hypothetical protein 0.0162 0.0951 0.2142
Echinococcus multilocularis neuropeptide FF receptor 2 0.0162 0.0951 0.1047
Brugia malayi Tachykinin-like peptides receptor 99D 0.0162 0.0951 0.2142
Entamoeba histolytica hypothetical protein 0.0111 0.0579 0.1887
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Echinococcus granulosus tachykinin peptides receptor 99D 0.0162 0.0951 0.1047
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0162 0.0951 0.1047
Brugia malayi PHD-finger family protein 0.0064 0.0238 0.0537
Brugia malayi hypothetical protein 0.0162 0.0951 0.2142
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0162 0.0951 0.1047
Schistosoma mansoni biogenic amine (5HT) receptor 0.0162 0.0951 0.2157
Trypanosoma cruzi hypothetical protein, conserved 0.0219 0.1368 0.5579
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0144 0.0573
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.004 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.0111 0.0576 0.1297
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0162 0.0951 0.2157
Loa Loa (eye worm) hypothetical protein 0.0219 0.1368 0.308
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0061 0.0139
Loa Loa (eye worm) hypothetical protein 0.0102 0.0514 0.1157
Echinococcus multilocularis fmrfamide receptor 0.0162 0.0951 0.1047
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.004 0.0061 0.5
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.004 0.0061 0.0067
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0162 0.0951 0.1047
Mycobacterium leprae Probable lipase LipE 0.0219 0.1368 1
Echinococcus multilocularis somatostatin receptor 0.0162 0.0951 0.1047
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0047 0.0109 0.012
Echinococcus granulosus serotonin receptor 0.0162 0.0951 0.1047
Echinococcus multilocularis neuropeptides capa receptor 0.0162 0.0951 0.1047
Loa Loa (eye worm) G-protein coupled receptor 0.0162 0.0951 0.2142
Mycobacterium leprae conserved hypothetical protein 0.0219 0.1368 1
Entamoeba histolytica hypothetical protein 0.0111 0.0579 0.1887
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0117 0.062 0.1959
Schistosoma mansoni amine GPCR 0.0162 0.0951 0.2157
Echinococcus granulosus lysine specific demethylase 5A 0.0078 0.0338 0.0372
Onchocerca volvulus 0.0162 0.0951 0.1771
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.0436 0.048
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0162 0.0951 0.2142
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Onchocerca volvulus 0.0186 0.113 0.2126
Schistosoma mansoni growth hormone secretagogue receptor 0.0162 0.0951 0.2157
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Echinococcus multilocularis allatostatin A receptor 0.0162 0.0951 0.1047
Trypanosoma cruzi hypothetical protein, conserved 0.0366 0.2448 1
Schistosoma mansoni biogenic amine receptor 0.0162 0.0951 0.2157
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0047 0.0109 0.012
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.0436 0.048
Schistosoma mansoni sodium/chloride dependent transporter 0.0237 0.1506 0.3415
Echinococcus multilocularis neuropeptide receptor A26 0.0162 0.0951 0.1047
Schistosoma mansoni amine GPCR 0.0162 0.0951 0.2157
Schistosoma mansoni neuropeptide receptor 0.0162 0.0951 0.2157
Loa Loa (eye worm) hypothetical protein 0.0038 0.0044 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0162 0.0951 0.2157
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0117 0.062 0.1218
Loa Loa (eye worm) hypothetical protein 0.0049 0.0128 0.0287
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.0338 0.0766
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0579 0.0637
Schistosoma mansoni hypothetical protein 0.0162 0.0951 0.2157
Brugia malayi jmjC domain containing protein 0.0078 0.0338 0.0761
Echinococcus multilocularis lysine specific demethylase 5A 0.0078 0.0338 0.0372
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0162 0.0951 0.2142
Giardia lamblia DNA repair protein RAD52 0.0376 0.2519 1
Toxoplasma gondii FATC domain-containing protein 0.0049 0.0128 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0258 0.0508
Toxoplasma gondii PHD-finger domain-containing protein 0.0064 0.0238 0.1356
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0162 0.0951 0.2157
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Brugia malayi beta-lactamase family protein 0.0219 0.1368 0.308
Echinococcus multilocularis voltage gated potassium channel 0.0047 0.0109 0.012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0162 0.0951 0.2157
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0162 0.0951 0.1047
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0144 0.0923
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0538 0.1057
Mycobacterium tuberculosis Probable lipase LipE 0.0219 0.1368 0.1329
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0061 0.0139
Trypanosoma brucei hypothetical protein, conserved 0.0219 0.1368 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0038 0.0046 0.005
Echinococcus granulosus neuropeptides capa receptor 0.0162 0.0951 0.1047
Trichomonas vaginalis D-aminoacylase, putative 0.0219 0.1368 0.2689
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Echinococcus multilocularis PHD finger protein rhinoceros 0.0064 0.0238 0.0262
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0162 0.0951 0.1047
Mycobacterium tuberculosis Probable lipase LipD 0.0219 0.1368 0.1329
Leishmania major hypothetical protein, conserved 0.0383 0.2571 1
Schistosoma mansoni adenoreceptor 0.0162 0.0951 0.2157
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0579 0.1313
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0173 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0473 0.0929
Trichomonas vaginalis esterase, putative 0.0219 0.1368 0.2689
Brugia malayi putative neuropeptide receptor NPR1 0.0162 0.0951 0.2142
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0088 0.0407 0.0448
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Echinococcus multilocularis peregrin 0.0064 0.0238 0.0262
Echinococcus granulosus 7tm_1 domain containing protein 0.0162 0.0951 0.1047
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0049 0.0128 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0538 0.1057
Brugia malayi hypothetical protein 0.0162 0.0951 0.2142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0316 0.0621
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0638 0.4441 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0162 0.0951 0.2157
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0117 0.062 0.1959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0538 0.1057
Brugia malayi hypothetical protein 0.004 0.0061 0.0138
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0107 0.0549 0.1763
Brugia malayi RE15519p 0.0162 0.0951 0.2142
Onchocerca volvulus 0.0162 0.0951 0.1771
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0161 0.0949 0.1045
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Loa Loa (eye worm) hypothetical protein 0.0052 0.0144 0.0325
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0162 0.0951 0.2157
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0088 0.0407 0.1649
Schistosoma mansoni sodium-dependent amino acid transporter 0.004 0.0061 0.0139
Echinococcus multilocularis rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0061 0.0138
Mycobacterium ulcerans esterase/lipase LipP 0.0219 0.1368 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0162 0.0951 0.1047
Echinococcus granulosus G protein coupled receptor 139 0.0162 0.0951 0.1047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0162 0.0951 0.2157
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0211 0.1313 0.1446
Onchocerca volvulus 0.0162 0.0951 0.1771
Brugia malayi ORL1-like opioid receptor 0.0162 0.0951 0.2142
Mycobacterium tuberculosis Conserved protein 0.0219 0.1368 0.1329
Brugia malayi follicle stimulating hormone receptor 0.0162 0.0951 0.2142
Echinococcus granulosus jumonji domain containing protein 0.009 0.0423 0.0466
Brugia malayi beta-lactamase family protein 0.0219 0.1368 0.308
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0162 0.0951 0.2157
Brugia malayi Serotonin receptor 0.0162 0.0951 0.2142
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0064 0.0234 0.1592
Mycobacterium ulcerans hypothetical protein 0.0219 0.1368 1
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0044 0.0099
Brugia malayi G protein-coupled receptor 0.0162 0.0951 0.2142
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1049 0.7455 0.8207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0162 0.0951 0.2157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0117 0.062 0.1218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0473 0.0929
Onchocerca volvulus Alhambra homolog 0.0064 0.0238 0.0353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0128 0.0251
Echinococcus multilocularis G protein coupled receptor 139 0.0162 0.0951 0.1047
Mycobacterium ulcerans beta-lactamase 0.0219 0.1368 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0049 0.0128 0.0289
Brugia malayi hypothetical protein 0.0162 0.0951 0.2142
Loa Loa (eye worm) beta-lactamase 0.0219 0.1368 0.308
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0128 0.0287
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0038 0.0046 0.005
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0237 0.1506 0.3391
Schistosoma mansoni apoferritin-2 0.0038 0.0045 0.0102
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0144 0.0635
Mycobacterium tuberculosis Probable hydrolase 0.0219 0.1368 0.1329
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Trichomonas vaginalis D-aminoacylase, putative 0.0219 0.1368 0.2689
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0061 0.0138
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0219 0.1368 0.1329
Schistosoma mansoni biogenic amine receptor 0.0162 0.0951 0.2157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0473 0.0929
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0061 0.0139
Schistosoma mansoni histamine h1 receptor 0.0162 0.0951 0.2157
Trichomonas vaginalis penicillin-binding protein, putative 0.0219 0.1368 0.2689
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Entamoeba histolytica hypothetical protein 0.0107 0.0549 0.1763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0407 0.0801
Echinococcus granulosus rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Echinococcus granulosus alpha 1A adrenergic receptor 0.0162 0.0951 0.1047
Onchocerca volvulus 0.0162 0.0951 0.1771
Brugia malayi G protein-coupled receptor F59B2.13 0.0162 0.0951 0.2142
Trichomonas vaginalis ferritin, putative 0.0038 0.0045 0.0089
Echinococcus granulosus tm gpcr rhodopsin 0.0162 0.0951 0.1047
Onchocerca volvulus 0.0237 0.1506 0.2875
Loa Loa (eye worm) hypothetical protein 0.0047 0.0109 0.0245
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0161 0.0949 0.2138
Loa Loa (eye worm) hypothetical protein 0.0186 0.113 0.2544
Echinococcus granulosus geminin 0.0181 0.1091 0.1201
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0162 0.0951 0.1047
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0061 0.0139
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0162 0.0951 0.2157
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0162 0.0951 0.1047
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Leishmania major phosphatidylinositol 3-kinase, putative 0.0088 0.0407 0.1084
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Mycobacterium tuberculosis Conserved protein 0.0219 0.1368 0.1329
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0219 0.1368 0.1329
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Loa Loa (eye worm) hypothetical protein 0.004 0.0061 0.0138
Schistosoma mansoni voltage-gated potassium channel 0.0176 0.1058 0.24
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0162 0.0951 0.2142
Echinococcus granulosus g-protein coupled receptor 0.0162 0.0951 0.1047
Onchocerca volvulus 0.0219 0.1368 0.26
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.0219 0.1368 0.308
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0109 0.0247
Echinococcus granulosus biogenic amine 5HT receptor 0.0162 0.0951 0.1047
Onchocerca volvulus 0.0162 0.0951 0.1771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0407 0.0801
Schistosoma mansoni ferritin 0.0038 0.0045 0.0102
Schistosoma mansoni microtubule-associated protein tau 0.0634 0.4409 1
Brugia malayi AKH receptor 0.0162 0.0951 0.2142
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0162 0.0951 0.2157
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0162 0.0951 0.2157
Onchocerca volvulus Neuropeptide F receptor homolog 0.0162 0.0951 0.1771
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0055 0.0169 0.0825
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0538 0.1057
Echinococcus multilocularis g protein coupled receptor 0.0162 0.0951 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0554 0.109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0128 0.0251
Loa Loa (eye worm) hypothetical protein 0.0219 0.1368 0.308
Schistosoma mansoni biogenic amine receptor 0.0162 0.0951 0.2157
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Loa Loa (eye worm) hypothetical protein 0.0219 0.1368 0.308
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0061 0.0139
Onchocerca volvulus 0.0162 0.0951 0.1771
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0579 0.0637
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0162 0.0951 0.2142
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0049 0.0128 0.014
Echinococcus granulosus neuropeptides capa receptor 0.0162 0.0951 0.1047
Brugia malayi Bromodomain containing protein 0.0064 0.0238 0.0537
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0237 0.1506 0.3415
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0162 0.0951 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0258 0.0508
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0061 0.0139
Echinococcus multilocularis serotonin receptor 0.0162 0.0951 0.1047
Plasmodium vivax hypothetical protein, conserved 0.0064 0.0238 0.1356
Loa Loa (eye worm) hypothetical protein 0.004 0.0061 0.0138
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0061 0.0139
Loa Loa (eye worm) phosphatidylinositol 3 0.0088 0.0407 0.0917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0407 0.0801
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0108 0.0555 0.3968
Brugia malayi hypothetical protein 0.0162 0.0951 0.2142
Brugia malayi hypothetical protein 0.0033 0.001 0.0023
Toxoplasma gondii target of rapamycin (TOR), putative 0.0105 0.0538 0.3648
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0117 0.062 0.2058
Onchocerca volvulus 0.0168 0.0998 0.1865
Echinococcus granulosus g protein coupled receptor 0.0162 0.0951 0.1047
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0061 0.0139
Schistosoma mansoni hypothetical protein 0.0038 0.0044 0.0099
Brugia malayi hypothetical protein 0.0162 0.0951 0.2142
Schistosoma mansoni amine GPCR 0.0162 0.0951 0.2157
Loa Loa (eye worm) hypothetical protein 0.0055 0.0173 0.0388
Onchocerca volvulus 0.0162 0.0951 0.1771
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0162 0.0951 0.1047
Echinococcus multilocularis jumonji domain containing protein 0.009 0.0423 0.0466
Echinococcus multilocularis serotonin transporter 0.0237 0.1506 0.1658
Onchocerca volvulus 0.0162 0.0951 0.1771
Toxoplasma gondii ABC1 family protein 0.0219 0.1368 1
Echinococcus granulosus tm gpcr rhodopsin 0.0162 0.0951 0.1047
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0162 0.0951 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0004 0.0008
Echinococcus granulosus peptide allatostatin:somatostatin 0.0162 0.0951 0.1047
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Schistosoma mansoni hypothetical protein 0.0181 0.1091 0.2474
Echinococcus granulosus hypothetical protein 0.0162 0.0951 0.1047
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0162 0.0951 0.2157
Echinococcus granulosus rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Echinococcus granulosus sex peptide receptor 0.0162 0.0951 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0538 0.1057
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0088 0.0407 0.1084
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0061 0.0138
Schistosoma mansoni neuropeptide F-like receptor 0.0162 0.0951 0.2157
Schistosoma mansoni voltage-gated potassium channel 0.0176 0.1058 0.24
Schistosoma mansoni hypothetical protein 0.0162 0.0951 0.2157
Leishmania major hypothetical protein, conserved 0.0219 0.1368 0.5041
Echinococcus granulosus neuropeptide receptor A26 0.0162 0.0951 0.1047
Trichomonas vaginalis set domain proteins, putative 0.0726 0.5086 1
Onchocerca volvulus 0.0162 0.0951 0.1771
Echinococcus multilocularis rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Schistosoma mansoni eyes absent homolog 0.0102 0.0514 0.1166
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0061 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0472 0.0929
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0436 0.099
Brugia malayi hypothetical protein 0.0052 0.0144 0.0325
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0412 0.0453
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.0436 0.099
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Loa Loa (eye worm) jmjC domain-containing protein 0.0133 0.0741 0.167
Trypanosoma cruzi target of rapamycin kinase 3 0.0108 0.0555 0.2252
Echinococcus multilocularis ferritin 0.0038 0.0045 0.005
Onchocerca volvulus 0.0219 0.1368 0.26
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0489 0.0962
Brugia malayi GnHR receptor homolog 0.0162 0.0951 0.2142
Loa Loa (eye worm) hypothetical protein 0.0219 0.1368 0.308
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0117 0.062 0.0682
Loa Loa (eye worm) hypothetical protein 0.004 0.0061 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0162 0.0951 0.2157
Echinococcus granulosus neuropeptide Y receptor 0.0162 0.0951 0.1047
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0162 0.0951 0.2157
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0162 0.0951 0.2142
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0064 0.0238 0.0541
Echinococcus granulosus rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Brugia malayi FAT domain containing protein 0.0038 0.0046 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0128 0.0251
Onchocerca volvulus 0.0162 0.0951 0.1771
Loa Loa (eye worm) hypothetical protein 0.004 0.0061 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0554 0.109
Schistosoma mansoni jumonji domain containing protein 0.0168 0.0995 0.2257
Schistosoma mansoni ferritin 0.0038 0.0045 0.0102
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0162 0.0951 0.2142
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0117 0.062 0.2519
Schistosoma mansoni ferritin 0.0038 0.0045 0.0102
Trichomonas vaginalis penicillin-binding protein, putative 0.0219 0.1368 0.2689
Brugia malayi Melatonin receptor type 1A 0.0162 0.0951 0.2142
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0219 0.1368 0.308
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0047 0.0109 0.0245
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0219 0.1368 0.1329
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0162 0.0951 0.2142
Echinococcus multilocularis neuropeptides capa receptor 0.0162 0.0951 0.1047
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0108 0.0555 0.1691
Loa Loa (eye worm) hypothetical protein 0.0168 0.0998 0.2249
Echinococcus granulosus orexin receptor type 2 0.0162 0.0951 0.1047
Schistosoma mansoni hypothetical protein 0.0162 0.0951 0.2157
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0144 0.4682
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0088 0.0407 0.0917
Brugia malayi Serotonin receptor 0.0162 0.0951 0.2142
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Loa Loa (eye worm) TYRA-2 protein 0.0162 0.0951 0.2142
Echinococcus granulosus rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Echinococcus granulosus dro:myosuppressin receptor 0.0162 0.0951 0.1047
Mycobacterium ulcerans lipase LipD 0.0219 0.1368 1
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.1482 0.3338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0538 0.1057
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0161 0.0949 0.2138
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0162 0.0951 0.1047
Loa Loa (eye worm) hypothetical protein 0.0237 0.1506 0.3391
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0046 0.009
Schistosoma mansoni hypothetical protein 0.0162 0.0951 0.2157
Loa Loa (eye worm) hypothetical protein 0.0091 0.0436 0.0983
Echinococcus multilocularis geminin 0.0181 0.1091 0.1201
Brugia malayi Pre-SET motif family protein 0.0091 0.0436 0.0983
Echinococcus granulosus fmrfamide receptor 0.0162 0.0951 0.1047
Echinococcus granulosus ferritin 0.0038 0.0045 0.005
Echinococcus granulosus microtubule associated protein 2 0.0634 0.4409 0.4854
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0049 0.0128 0.08
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0162 0.0951 0.1047
Echinococcus granulosus somatostatin receptor 0.0162 0.0951 0.1047
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0162 0.0951 0.1047
Echinococcus multilocularis neuropeptide Y receptor 0.0162 0.0951 0.1047
Brugia malayi neuropeptide F receptor 0.0162 0.0951 0.2142
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0161 0.0949 0.1045
Loa Loa (eye worm) PHD-finger family protein 0.0064 0.0238 0.0537
Echinococcus multilocularis rhodopsin orphan GPCR 0.0162 0.0951 0.1047
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.0436 0.2871
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.004 0.0061 0.0067
Loa Loa (eye worm) hypothetical protein 0.0237 0.1506 0.3391
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0117 0.062 0.4451
Echinococcus multilocularis orexin receptor type 2 0.0162 0.0951 0.1047
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0144 0.0635
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0162 0.0951 0.2157
Schistosoma mansoni hypothetical protein 0.0181 0.1091 0.2474
Schistosoma mansoni apoferritin-2 0.0038 0.0045 0.0102
Echinococcus granulosus voltage gated potassium channel 0.0047 0.0109 0.012
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0162 0.0951 0.1047
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0376 0.2519 1
Echinococcus granulosus neuropeptide receptor 0.0162 0.0951 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.0472 0.0929
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0162 0.0951 0.2157
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0162 0.0951 0.2157
Echinococcus multilocularis serotonin receptor 0.0162 0.0951 0.1047
Echinococcus multilocularis g protein coupled receptor 0.0162 0.0951 0.1047
Schistosoma mansoni hypothetical protein 0.0064 0.0238 0.0541
Echinococcus granulosus neuropeptide s receptor 0.0162 0.0951 0.1047
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0162 0.0951 0.1047
Echinococcus multilocularis neuropeptide s receptor 0.0162 0.0951 0.1047
Onchocerca volvulus 0.0091 0.0436 0.0747
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0162 0.0951 0.1047
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0162 0.0951 0.1047
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0049 0.0128 0.0505
Echinococcus multilocularis beta LACTamase domain containing family member 0.0219 0.1368 0.1506
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0162 0.0951 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0554 0.109
Schistosoma mansoni ferritin light chain 0.0038 0.0045 0.0102
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Brugia malayi hypothetical protein 0.0162 0.0951 0.2142
Brugia malayi Dopamine receptor protein 2 0.0162 0.0951 0.2142
Echinococcus multilocularis tumor protein p63 0.1271 0.9084 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0088 0.0407 0.0924
Onchocerca volvulus 0.0162 0.0951 0.1771
Mycobacterium tuberculosis Conserved protein 0.0219 0.1368 0.1329
Loa Loa (eye worm) hypothetical protein 0.0033 0.0004 0.0009
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0211 0.1313 0.1446
Onchocerca volvulus 0.0162 0.0951 0.1771
Onchocerca volvulus 0.0162 0.0951 0.1771
Echinococcus multilocularis expressed protein 0.0038 0.0045 0.005
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Schistosoma mansoni opsin-like receptor 0.0162 0.0951 0.2157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0108 0.0554 0.109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0258 0.0508
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Loa Loa (eye worm) hypothetical protein 0.0162 0.0951 0.2142
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.0436 0.048
Loa Loa (eye worm) hypothetical protein 0.0064 0.0238 0.0537
Loa Loa (eye worm) melatonin receptor type 1A 0.0162 0.0951 0.2142
Brugia malayi hypothetical protein 0.0162 0.0951 0.2142
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0061 0.0138
Schistosoma mansoni opsin-like receptor 0.0162 0.0951 0.2157

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 10 nM In vitro 50 % Maximal response in jugular vein expressing B2 receptor ChEMBL. 6118437
pD (functional) < 4 M In vitro 50 % Maximal response in jugular vein expressing B2 receptor ChEMBL. 6118437
Relative affinity (functional) < 0.01 % Percent agonistic activity in rabbit jugular vein expressing B2 receptor relative to bradykinin ChEMBL. 6118437

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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