TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 309.319 | Formula: C17H15N3O3
H donors: 3 H acceptors: 2 LogP: 2.57 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1O)C(=O)N/N=C/c1c[nH]c2c1cccc2
InChi: 1S/C17H15N3O3/c1-23-16-8-11(6-7-15(16)21)17(22)20-19-10-12-9-18-14-5-3-2-4-13(12)14/h2-10,18,21H,1H3,(H,20,22)/b19-10+
InChiKey: MNGWTRIVKCGHEF-VXLYETTFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.1041	1	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0223	0.2096	0.2548
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0226	0.2176
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0108	0.0986	0.4584
Onchocerca volvulus		0.0038	0.0315	0.0267
Echinococcus granulosus	SWI:SNF complex subunit SMARCC2	0.0067	0.0591	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0315	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0107	0.0106
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0376	0.0443
Echinococcus granulosus	GPCR family 2	0.0015	0.0093	0.0097
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0073	0.065	0.0778
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0119	0.1093	0.1342
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0009	0.0029	0.0018
Loa Loa (eye worm)	doublecortin family protein	0.0038	0.0315	0.0342
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.0986	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0069	0.0067
Brugia malayi	Cytochrome P450 family protein	0.0028	0.0212	0.0224
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.0082	0.0083
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0226	0.2176
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0053	0.0039
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0226	0.0952
Onchocerca volvulus		0.0027	0.0203	0.0138
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0853	0.8187	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0014	0.0017
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0083	0.0078
Echinococcus multilocularis		0.001	0.0045	0.0038
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0853	0.8187	1
Brugia malayi	Cytochrome P450 family protein	0.001	0.0045	0.0035
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0047	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0853	0.8187	0.9267
Brugia malayi	hypothetical protein	0.0038	0.0315	0.0342
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0007	0.0014	0.0017
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0149	0.0165
Schistosoma mansoni	hypothetical protein	0.0033	0.0266	0.0325
Echinococcus granulosus	death domain containing protein	0.0014	0.0082	0.0083
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0376	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0047	0.0037
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0053	0.0039
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0169	0.1574	0.1908
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0223	0.2096	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0101	0.0099
Mycobacterium tuberculosis	Probable dehydrogenase	0.0107	0.0978	0.1195
Loa Loa (eye worm)	hypothetical protein	0.0853	0.8187	0.9267
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0149	0.0165
Toxoplasma gondii	histone lysine-specific demethylase	0.0223	0.2096	1
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0223	0.2096	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0853	0.8187	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0415	0.0454
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0397	0.1783
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0009	0.0029	0.0018
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0107	0.0978	0.1195
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0083	0.0078
Plasmodium falciparum	protoporphyrinogen oxidase	0.0223	0.2096	1
Leishmania major	cytochrome p450-like protein	0.0028	0.0212	0.0811
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0226	0.0952
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0149	0.1385
Schistosoma mansoni	hypothetical protein	0.0015	0.0093	0.0114
Trypanosoma brucei	trypanothione reductase	0.0047	0.0397	0.3743
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0223	0.2096	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0069	0.0067
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0101	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0251	0.0268
Plasmodium vivax	hypothetical protein, conserved	0.0223	0.2096	1
Brugia malayi	amine oxidase, flavin-containing family protein	0.029	0.2743	0.3094
Echinococcus multilocularis	Ankyrin	0.0014	0.0083	0.0084
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0149	0.0153
Schistosoma mansoni	DNA helicase recq1	0.0009	0.0029	0.0035
Plasmodium falciparum	glutathione reductase	0.0047	0.0397	0.1783
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0101	0.0272
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.0298	0.0347
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0014	0.0017
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0223	0.2096	1
Trichomonas vaginalis	DNA helicase recq, putative	0.0011	0.0053	0.0404
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0101	0.0272
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0376	0.0443
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0028	0.0212	0.0167
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0203	0.0214
Echinococcus multilocularis	musashi	0.0027	0.0203	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0266	0.0286
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0093	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0069	0.0062
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.0082	0.01
Plasmodium falciparum	LCCL domain-containing protein	0.0038	0.0315	0.1387
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0226	0.0623
Leishmania major	trypanothione reductase	0.0047	0.0397	0.1716
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.0101	0.0093
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0226	0.2176
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0214
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0376	0.041
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0397	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2096	0.2361
Echinococcus multilocularis	6 phosphofructokinase	0.0108	0.0986	0.1189
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0226	0.2176
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0101	0.0351
Schistosoma mansoni	hypothetical protein	0.0015	0.0093	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0064	0.0057
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0226	0.2176
Loa Loa (eye worm)	6-phosphofructokinase	0.0108	0.0986	0.1101
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0101	0.0896
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0101	0.0594
Schistosoma mansoni	6-phosphofructokinase	0.0108	0.0986	0.1204
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.0986	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0226	0.0952
Mycobacterium ulcerans	dehydrogenase	0.0223	0.2096	0.206
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.0298	0.0321
Brugia malayi	Thioredoxin reductase	0.0047	0.0397	0.0434
Entamoeba histolytica	hypothetical protein	0.0067	0.0591	0.5766
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0376	0.041
Echinococcus granulosus	Ankyrin	0.0014	0.0083	0.0084
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0101	0.0272
Echinococcus granulosus	netrin receptor unc 5	0.0014	0.0082	0.0083
Toxoplasma gondii	cytochrome p450 superfamily protein	0.001	0.0045	0.0081
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0016	0.0101	0.0072
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0203	0.0248
Schistosoma mansoni	loxhd1	0.0038	0.0315	0.0385
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0101	0.0351
Echinococcus granulosus	voltage gated potassium channel	0.0011	0.0047	0.004
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0226	0.0711
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0101	0.0351
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0397	0.0434
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0082	0.0077
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0108	0.0986	0.4584
Echinococcus granulosus	intermediate filament protein	0.0027	0.0203	0.0231
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0029	0.0226	0.1847
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0083	0.0078
Schistosoma mansoni	SWI/SNF complex-related	0.0067	0.0591	0.0722
Mycobacterium ulcerans	6-phosphofructokinase	0.0108	0.0986	0.0944
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0108	0.0986	0.1205
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0093	0.009
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0169	0.1574	0.1908
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0019	0.0124	0.046
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0011	0.0047	0.004
Schistosoma mansoni	hypothetical protein	0.0166	0.1544	0.1886
Schistosoma mansoni	amine oxidase	0.0223	0.2096	0.2561
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0223	0.2096	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.0212	0.0224
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0226	0.0623
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0203	0.0214
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.0986	1
Brugia malayi	intermediate filament protein	0.0027	0.0203	0.0214
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0108	0.0986	1
Echinococcus granulosus	lamin	0.0027	0.0203	0.0231
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0101	0.0272
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.0082	0.0083
Onchocerca volvulus		0.092	0.8833	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0274	0.2679
Trypanosoma cruzi	cytochrome P450, putative	0.0028	0.0212	0.0811
Schistosoma mansoni	lamin	0.0027	0.0203	0.0248
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.0101	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0093	0.009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0315	0.0342
Schistosoma mansoni	hypothetical protein	0.0014	0.0082	0.01
Schistosoma mansoni	hypothetical protein	0.0015	0.0093	0.0114
Schistosoma mansoni	hypothetical protein	0.0015	0.0093	0.0114
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0107	0.0978	0.1195
Schistosoma mansoni	amine oxidase	0.0223	0.2096	0.2561
Echinococcus multilocularis	voltage gated potassium channel	0.0011	0.0047	0.004
Brugia malayi	SWIRM domain containing protein	0.0067	0.0591	0.0654
Mycobacterium tuberculosis	Probable reductase	0.0107	0.0978	0.1195
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0107	0.0978	0.4545
Echinococcus granulosus	lipoxygenase domain containing protein	0.0038	0.0315	0.0369
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0119	0.1093	0.1342
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0266	0.0286
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0226	0.0952
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0223	0.2096	1
Echinococcus granulosus	6 phosphofructokinase	0.0108	0.0986	0.1189
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0101	0.0351
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0038	0.0315	0.0369
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.006	0.0051
Leishmania major	ATP-dependent phosphofructokinase	0.0108	0.0986	0.4584
Brugia malayi	hypothetical protein	0.0038	0.0315	0.0342
Brugia malayi	phosphofructokinase	0.0108	0.0986	0.1101
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.006	0.0051
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0397	0.1783
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0101	0.0272
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.033	0.0403
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.0101	0.0056
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0009	0.0029	0.0016
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0101	0.0107
Schistosoma mansoni	voltage-gated potassium channel	0.0007	0.0014	0.0017
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0397	0.0469
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0415	0.0454
Brugia malayi	cytochrome P450	0.001	0.0045	0.0035
Echinococcus granulosus	geminin	0.0166	0.1544	0.1872
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0082	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0064	0.0057
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0029	0.0226	0.1406
Entamoeba histolytica	SWIRM domain protein	0.0067	0.0591	0.5766
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0014	0.0083	0.0102
Brugia malayi	Uncoordinated protein 44	0.0014	0.0082	0.0077
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0101	0.0272
Toxoplasma gondii	SWIRM domain-containing protein	0.0067	0.0591	0.2719
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0007	0.0014	0.0017
Brugia malayi	Cytochrome P450 family protein	0.0028	0.0212	0.0224
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.0986	1
Plasmodium falciparum	glutathione reductase	0.0016	0.0101	0.0351
Plasmodium vivax	hypothetical protein, conserved	0.0223	0.2096	1
Plasmodium vivax	multidomain scavenger receptor, putative	0.0038	0.0315	0.1157
Echinococcus granulosus	lamin dm0	0.0027	0.0203	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2096	0.2361
Echinococcus multilocularis	RUN	0.0038	0.0315	0.0369
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0397	0.1716
Schistosoma mansoni	rab6-interacting	0.0038	0.0315	0.0385
Loa Loa (eye worm)	cytochrome P450	0.001	0.0045	0.0035
Echinococcus granulosus	cytochrome P450 2K1	0.001	0.0045	0.0038
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0101	0.0351
Schistosoma mansoni	DNA helicase recq5	0.0009	0.0029	0.0035
Mycobacterium ulcerans	oxidoreductase	0.0223	0.2096	0.206
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0415	0.0454
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0101	0.1291
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0226	0.2176
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0101	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0274	0.2679
Echinococcus multilocularis		0.0223	0.2096	0.2548
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0101	0.0272
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0029	0.0016
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0226	0.0952
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0226	0.0711
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0376	0.0459
Leishmania major	UDP-galactopyranose mutase	0.0223	0.2096	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0038	0.0315	0.0369
Schistosoma mansoni	polycystin 1-related	0.0038	0.0315	0.0385
Schistosoma mansoni	netrin receptor unc5	0.0014	0.0082	0.01
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0108	0.0986	1
Entamoeba histolytica	SWIRM domain protein	0.0067	0.0591	0.5766
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.0986	1
Loa Loa (eye worm)	hypothetical protein	0.029	0.2743	0.3094
Loa Loa (eye worm)	phosphofructokinase	0.0108	0.0986	0.1101
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0053	0.0086
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0029	0.00000000018587
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0226	0.2176
Schistosoma mansoni	hypothetical protein	0.0038	0.0315	0.0385
Schistosoma mansoni	lipoxygenase	0.01	0.0906	0.1107
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0223	0.2096	1
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0223	0.2096	1
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0397	0.1563
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0111	0.0109
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0093	0.0097
Echinococcus multilocularis	Polycystic kidney disease protein	0.0038	0.0315	0.0369
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0014	0.0081	0.0252
Brugia malayi	Doublecortin family protein	0.0038	0.0315	0.0342
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.0212	0.0224
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0038	0.0315	0.0369
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0093	0.0097
Brugia malayi	6-phosphofructokinase	0.0108	0.0986	0.1101
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0376	0.0443
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0093	0.0097
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0149	0.0153
Echinococcus multilocularis	lamin	0.0027	0.0203	0.0231
Brugia malayi	Protein kinase domain containing protein	0.0014	0.0082	0.0077
Loa Loa (eye worm)	hypothetical protein	0.092	0.8833	1
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0009	0.0029	0.0018
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0223	0.2096	0.2548
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.0397	0.0451
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0101	0.0594
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0101	0.0124
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0591	0.5937
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0093	0.0097
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0093	0.009
Schistosoma mansoni	6-phosphofructokinase	0.0108	0.0986	0.1204
Loa Loa (eye worm)	CYP4Cod1	0.0028	0.0212	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0198	0.0208
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0101	0.0896
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0223	0.2096	0.206
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0014	0.0017
Brugia malayi	glutathione reductase	0.0047	0.0397	0.0434
Schistosoma mansoni	cytochrome P450	0.001	0.0045	0.0055
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0397	0.1563
Brugia malayi	hypothetical protein	0.0223	0.2096	0.2361
Schistosoma mansoni	blooms syndrome DNA helicase	0.0017	0.0106	0.0129
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0149	0.1385
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.0101	0.0056
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0073	0.065	0.0778
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0397	0.0469
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0011	0.0047	0.004
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0101	0.0272
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.0986	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0101	0.0594
Schistosoma mansoni	hypothetical protein	0.0166	0.1544	0.1886
Schistosoma mansoni	lamin	0.0027	0.0203	0.0248
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0101	0.5
Trypanosoma cruzi	cytochrome P450, putative	0.0028	0.0212	0.0811
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0082	0.0077
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0101	0.0272
Loa Loa (eye worm)	6-phosphofructokinase	0.0108	0.0986	0.1101
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0376	0.0443
Echinococcus granulosus	Polycystic kidney disease protein	0.0038	0.0315	0.0369
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0107	0.0978	0.1195
Loa Loa (eye worm)	cytochrome P450 family protein	0.001	0.0045	0.0035
Mycobacterium tuberculosis	Possible oxidoreductase	0.0223	0.2096	0.2628
Echinococcus multilocularis	netrin receptor unc 5	0.0014	0.0082	0.0083
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0047	0.0057
Onchocerca volvulus		0.0027	0.0203	0.0138
Mycobacterium ulcerans	monoamine oxidase	0.0223	0.2096	0.206
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0011	0.0047	0.0037
Trypanosoma brucei	cytochrome P450, putative	0.0028	0.0212	0.177
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0029	0.0016
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0093	0.009
Brugia malayi	SWIRM domain containing protein	0.092	0.8833	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0101	0.0594
Trichomonas vaginalis	conserved hypothetical protein	0.0067	0.0591	0.5937
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.0298	0.0321
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0223	0.2096	0.2628
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0591	0.0654
Echinococcus multilocularis	SWI:SNF complex subunit SMARCC2	0.0067	0.0591	0.0706
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0107	0.0978	0.1195
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0101	0.0107
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0223	0.2096	0.2561
Brugia malayi	Death domain containing protein	0.0014	0.0082	0.0077
Schistosoma mansoni	lipoxygenase	0.0169	0.1574	0.1923
Brugia malayi	6-phosphofructokinase	0.0108	0.0986	0.1101
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0376	0.0459
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.0101	0.0093
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0818	0.7848	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0203	0.0214
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0119	0.1093	0.5107
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.0986	1
Schistosoma mansoni	rab6-interacting	0.0038	0.0315	0.0385
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0009	0.0029	0.0018
Giardia lamblia	hypothetical protein	0.0067	0.0591	1
Echinococcus granulosus	RUN	0.0038	0.0315	0.0369
Echinococcus multilocularis	lamin dm0	0.0027	0.0203	0.0231
Schistosoma mansoni	hypothetical protein	0.001	0.0045	0.0055
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.0298	0.0347
Brugia malayi	Cytochrome P450 family protein	0.001	0.0045	0.0035
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0101	0.0272
Mycobacterium tuberculosis	Probable oxidoreductase	0.0119	0.1093	0.1342
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0101	0.0272
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0223	0.2096	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0415	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0016
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.033	0.0403
Onchocerca volvulus		0.0038	0.0315	0.0267
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0101	0.0272
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0.0226	0.3503
Echinococcus multilocularis	geminin	0.0166	0.1544	0.1872

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 23 uM	Binding affinity for human Glucagon Receptor	ChEMBL.	11543683
IC50 (binding)	= 23 uM	Binding affinity for human Glucagon Receptor	ChEMBL.	11543683

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 176503