Detailed information for compound 177523

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.358 | Formula: C16H13N3O3S
  • H donors: 1 H acceptors: 5 LogP: -0.45 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccnc(c1)C1C2=C(O)CCC2=NC2=C1S(=O)(=O)CC2
  • InChi: 1S/C16H13N3O3S/c17-8-9-3-5-18-12(7-9)15-14-10(1-2-13(14)20)19-11-4-6-23(21,22)16(11)15/h3,5,7,15,20H,1-2,4,6H2
  • InChiKey: HXTLKNMPSQIWBO-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0167 0.1919 0.4335
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0155 0.1768 0.1768
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Schistosoma mansoni rab6-interacting 0.0023 0.0099 0.0099
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0155 0.1768 0.1768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.4124 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0252 0.2995 1
Schistosoma mansoni protein kinase 0.0155 0.1768 0.1768
Loa Loa (eye worm) TK/FAK protein kinase 0.0155 0.1768 0.3876
Echinococcus multilocularis SH2 motif 0.0221 0.2601 0.2601
Brugia malayi Protein kinase domain containing protein 0.0376 0.4563 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0704 0.241
Echinococcus multilocularis receptor type guanylyl cyclase 0.0155 0.1768 0.1768
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0021 0.0046
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.036 0.4354 0.9543
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0153 0.0323
Loa Loa (eye worm) hypothetical protein 0.0155 0.1768 0.3876
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0243 0.0543
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0376 0.4563 0.4563
Echinococcus multilocularis growth factor receptor bound protein 2 0.0221 0.2601 0.2601
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Echinococcus multilocularis survival motor neuron protein 1 0.0276 0.33 0.33
Loa Loa (eye worm) TK/CSK protein kinase 0.0155 0.1768 0.3876
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0155 0.1768 0.1768
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0258 0.0258
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0221 0.2601 0.5607
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Echinococcus granulosus activated cdc42 kinase 1 0.0155 0.1768 0.1768
Plasmodium falciparum tyrosine kinase-like protein 0.0155 0.1768 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0155 0.1768 0.1768
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.1065 0.2985
Brugia malayi hypothetical protein 0.0221 0.2601 0.5702
Echinococcus multilocularis integrin linked protein kinase 0.0155 0.1768 0.1768
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Entamoeba histolytica tyrosin kinase, putative 0.0155 0.1768 0.371
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0221 0.2601 0.5702
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.0243 0.0305
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0155 0.1768 0.371
Trichomonas vaginalis protein kinase atn1, putative 0.0155 0.1768 0.426
Onchocerca volvulus Tyrosine kinase homolog 0.0155 0.1768 0.3741
Echinococcus multilocularis microtubule associated protein 2 0.0806 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.1768 0.3876
Echinococcus granulosus tyrosine protein kinase csk 0.0155 0.1768 0.1768
Schistosoma mansoni hypothetical protein 0.0097 0.1031 0.1031
Brugia malayi SH2 domain containing protein 0.0376 0.4563 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0064 0.0623 0.0623
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0609 0.0609
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0027 0.0017
Leishmania major DNA polymerase eta, putative 0.0044 0.0361 0.0578
Echinococcus granulosus NCK adaptor protein 0.0221 0.2601 0.2601
Leishmania major protein kinase, putative 0.0155 0.1768 0.3973
Plasmodium vivax importin-beta 2, putative 0.0034 0.0233 0.0806
Trichomonas vaginalis CAMK family protein kinase 0.0155 0.1768 0.426
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.1072 0.1072
Echinococcus multilocularis c src tyrosine kinase 0.0376 0.4563 0.4563
Echinococcus granulosus lamin 0.0031 0.0206 0.0206
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0243 0.0295
Entamoeba histolytica hypothetical protein 0.0042 0.0339 0.0491
Loa Loa (eye worm) hypothetical protein 0.0376 0.4563 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Toxoplasma gondii protein kinase 0.0155 0.1768 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0233 0.0271
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0155 0.1768 0.3876
Schistosoma mansoni suppressor of cytokine signaling 0.0221 0.2601 0.2601
Plasmodium vivax SET domain protein, putative 0.0036 0.0258 0.0952
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0609 0.0609
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0243 0.0742
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0428 0.0993
Echinococcus granulosus ephrin type A receptor 4 A 0.0155 0.1768 0.1768
Echinococcus granulosus integrin linked protein kinase 0.0155 0.1768 0.1768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.4124 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.1768 0.3876
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.1768 0.426
Brugia malayi SH2 domain containing protein 0.0221 0.2601 0.5702
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Brugia malayi RhoGAP domain containing protein 0.0221 0.2601 0.5702
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0243 0.0865
Schistosoma mansoni lipoxygenase 0.0064 0.0623 0.0623
Brugia malayi ephrin receptor 1 precursor 0.0155 0.1768 0.3876
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Onchocerca volvulus 0.0376 0.4563 1
Schistosoma mansoni suppressor of cytokine signaling 0.0221 0.2601 0.2601
Echinococcus granulosus kinase suppressor of Ras 1 0.0155 0.1768 0.1768
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0155 0.1768 0.3876
Echinococcus granulosus tyrosine protein kinase pr2 0.0155 0.1768 0.1768
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0045 0.0377 0.0827
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0376 0.4563 0.4563
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0361 0.0578
Echinococcus granulosus retinal guanylyl cyclase 2 0.0155 0.1768 0.1768
Echinococcus multilocularis chromobox protein 1 0.0081 0.0836 0.0836
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Trypanosoma brucei Pseudokinase, putative 0.0155 0.1768 0.3973
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0376 0.4563 0.4563
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Loa Loa (eye worm) hypothetical protein 0.0034 0.0233 0.0511
Toxoplasma gondii thioredoxin reductase 0.0099 0.1065 0.5727
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0483 0.0483
Giardia lamblia Fructose-bisphosphate aldolase 0.0341 0.4124 1
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0206 0.0451
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Plasmodium falciparum protein kinase, putative 0.0155 0.1768 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0341 0.4124 0.9013
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0155 0.1768 0.1768
Loa Loa (eye worm) hypothetical protein 0.0155 0.1768 0.3876
Loa Loa (eye worm) TK/FER protein kinase 0.0376 0.4563 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0227 0.2675 0.7034
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0376 0.4563 0.4563
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0056 0.0512 0.0926
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0155 0.1768 0.371
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0064 0.0623 0.0623
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Echinococcus granulosus intermediate filament protein 0.0031 0.0206 0.0206
Onchocerca volvulus 0.0221 0.2601 0.5607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0483 0.0483
Onchocerca volvulus 0.0056 0.052 0.0944
Loa Loa (eye worm) hypothetical protein 0.0155 0.1768 0.3876
Treponema pallidum fructose-bisphosphate aldolase 0.0341 0.4124 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0376 0.4563 0.4563
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Entamoeba histolytica hypothetical protein 0.0042 0.0339 0.0491
Onchocerca volvulus 0.0155 0.1768 0.3741
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Entamoeba histolytica hypothetical protein 0.0042 0.0339 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.1768 0.426
Mycobacterium tuberculosis Conserved hypothetical protein 0.0186 0.2157 0.6955
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0021 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0216 0.0476
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Loa Loa (eye worm) hypothetical protein 0.0046 0.0384 0.0842
Onchocerca volvulus 0.0155 0.1768 0.3741
Brugia malayi hypothetical protein 0.0023 0.0099 0.0216
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0201 0.0192
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0723 0.0723
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0258 0.0258
Echinococcus granulosus tyrosine protein kinase Fyn 0.0376 0.4563 0.4563
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni tyrosine kinase 0.0376 0.4563 0.4563
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0221 0.2601 0.5702
Brugia malayi mbt repeat family protein 0.0056 0.0512 0.1122
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0221 0.2601 0.2601
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0232 0.0508
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0243 0.5
Onchocerca volvulus 0.0155 0.1768 0.3741
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0221 0.2601 0.2601
Onchocerca volvulus 0.0155 0.1768 0.3741
Toxoplasma gondii STE kinase 0.0155 0.1768 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0258 0.083
Entamoeba histolytica hypothetical protein 0.0155 0.1768 0.371
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0243 0.0295
Onchocerca volvulus 0.0376 0.4563 1
Loa Loa (eye worm) TK/FER protein kinase 0.0376 0.4563 1
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0072 0.0126
Brugia malayi SH2 domain containing protein 0.0221 0.2601 0.5702
Schistosoma mansoni tyrosine kinase 0.0376 0.4563 0.4563
Echinococcus granulosus SHC transforming protein 3 0.0221 0.2601 0.2601
Loa Loa (eye worm) hypothetical protein 0.0063 0.0609 0.1336
Onchocerca volvulus 0.0176 0.2039 0.4347
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0201 0.0192
Loa Loa (eye worm) RGC/RGC protein kinase 0.0155 0.1768 0.3876
Loa Loa (eye worm) TK/FER protein kinase 0.0376 0.4563 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0243 0.0865
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Schistosoma mansoni hypothetical protein 0.0097 0.1031 0.1031
Echinococcus granulosus tyrosine protein kinase 0.0155 0.1768 0.1768
Onchocerca volvulus 0.0221 0.2601 0.5607
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0155 0.1768 0.426
Brugia malayi Tensin 0.0221 0.2601 0.5702
Loa Loa (eye worm) hypothetical protein 0.0176 0.2039 0.447
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0483 0.1059
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0435 0.0757
Echinococcus multilocularis protein tyrosine kinase 0.0155 0.1768 0.1768
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0609 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0384 0.0887
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Loa Loa (eye worm) MBCTL1 0.0063 0.0609 0.1336
Loa Loa (eye worm) hypothetical protein 0.0155 0.1768 0.3876
Brugia malayi hypothetical protein 0.0155 0.1768 0.3876
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.1768 0.426
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.1065 0.2333
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Brugia malayi Immunoglobulin I-set domain containing protein 0.0155 0.1768 0.3876
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0155 0.1768 0.3876
Toxoplasma gondii hypothetical protein 0.0057 0.0527 0.2464
Plasmodium falciparum importin beta, putative 0.0034 0.0233 0.0806
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0483 0.0483
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0155 0.1768 0.371
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0377 0.0619
Plasmodium vivax glutathione reductase, putative 0.0099 0.1065 0.5784
Brugia malayi hypothetical protein 0.0376 0.4563 1
Echinococcus multilocularis activin receptor type 0.0155 0.1768 0.1768
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.1072 0.1072
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Brugia malayi Guanylyl cyclase protein 23 0.0155 0.1768 0.3876
Entamoeba histolytica receptor protein kinase, putative 0.0155 0.1768 0.371
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0376 0.4563 0.4563
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0627 0.3074
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0155 0.1768 0.3876
Brugia malayi SH2 domain containing protein 0.0221 0.2601 0.5702
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0155 0.1768 0.1768
Brugia malayi glutathione reductase 0.0099 0.1065 0.2333
Echinococcus granulosus tyrosine protein kinase shark 0.0376 0.4563 0.4563
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0155 0.1768 0.1768
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Onchocerca volvulus 0.0155 0.1768 0.3741
Brugia malayi SH2 domain containing protein 0.0221 0.2601 0.5702
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0153 0.0323
Loa Loa (eye worm) TK/EPH protein kinase 0.0155 0.1768 0.3876
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0243 0.0295
Trichomonas vaginalis ran, putative 0.0025 0.0121 0.0245
Onchocerca volvulus 0.0155 0.1768 0.3741
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0243 0.0295
Schistosoma mansoni tyrosine kinase 0.0376 0.4563 0.4563
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1768 0.1768
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.4124 1
Loa Loa (eye worm) TK/FER protein kinase 0.0155 0.1768 0.3876
Loa Loa (eye worm) glutathione reductase 0.0099 0.1065 0.2333
Onchocerca volvulus 0.0221 0.2601 0.5607
Schistosoma mansoni vav2 0.0221 0.2601 0.2601
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0099 0.0099
Loa Loa (eye worm) TK/FER protein kinase 0.0155 0.1768 0.3876
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.1065 0.2275
Plasmodium vivax protein kinase, putative 0.0155 0.1768 1
Schistosoma mansoni chromobox protein 0.0081 0.0836 0.0836
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0243 0.0243
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Echinococcus granulosus fibroblast growth factor receptor 4 0.0155 0.1768 0.1768
Loa Loa (eye worm) TK protein kinase 0.0155 0.1768 0.3876
Schistosoma mansoni adapter molecule crk 0.0221 0.2601 0.2601
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Loa Loa (eye worm) TK/EGFR protein kinase 0.0155 0.1768 0.3876
Onchocerca volvulus 0.0155 0.1768 0.3741
Schistosoma mansoni ephrin receptor 0.0155 0.1768 0.1768
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Trichomonas vaginalis AGC family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0221 0.2601 0.2601
Loa Loa (eye worm) TK/FER protein kinase 0.0155 0.1768 0.3876
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0127 0.0279
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0121 0.0133
Echinococcus granulosus polycomb protein SCMH1 0.0056 0.0512 0.0512
Loa Loa (eye worm) TK/DDR protein kinase 0.0155 0.1768 0.3876
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.4124 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0704 0.1676
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Echinococcus multilocularis heat shock protein 70 0.0155 0.1768 0.1768
Loa Loa (eye worm) protein kinase domain-containing protein 0.0155 0.1768 0.3876
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Loa Loa (eye worm) serine/threonine protein kinase 0.0155 0.1768 0.3876
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0167 0.1916 0.608
Echinococcus multilocularis tyrosine protein kinase csk 0.0155 0.1768 0.1768
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Onchocerca volvulus 0.0031 0.0206 0.024
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0167 0.1919 0.4335
Brugia malayi Raf kinase 0.0155 0.1768 0.3876
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0155 0.1768 1
Schistosoma mansoni DNA polymerase eta 0.0075 0.0754 0.0754
Entamoeba histolytica cysteine surface protein, putative 0.0155 0.1768 0.371
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0155 0.1768 0.1768
Echinococcus granulosus suppressor of cytokine signaling 7 0.0221 0.2601 0.2601
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0221 0.2601 0.2601
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0376 0.4563 0.4563
Brugia malayi RNA, U transporter 1 0.0096 0.1019 0.2232
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0221 0.2601 0.2601
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0155 0.1768 0.3876
Brugia malayi Pre-SET motif family protein 0.0244 0.2891 0.6336
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0376 0.4563 0.4563
Brugia malayi SH2 domain containing protein 0.0221 0.2601 0.5702
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0155 0.1768 0.1768
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Entamoeba histolytica hypothetical protein 0.0155 0.1768 0.371
Echinococcus granulosus hypothetical protein 0.0221 0.2601 0.2601
Loa Loa (eye worm) RGC/RGC protein kinase 0.0155 0.1768 0.3876
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0155 0.1768 0.3876
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Leishmania major protein kinase, putative 0.0155 0.1768 0.3973
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0155 0.1768 0.1768
Echinococcus multilocularis polycomb protein SCMH1 0.0056 0.0512 0.0512
Echinococcus multilocularis tyrosine protein kinase Abl 0.0376 0.4563 0.4563
Echinococcus multilocularis tensin 0.0221 0.2601 0.2601
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0072 0.0126
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0155 0.1768 0.371
Echinococcus multilocularis chromobox protein 1 0.0081 0.0836 0.0836
Entamoeba histolytica hypothetical protein 0.0155 0.1768 0.371
Echinococcus granulosus N chimaerin 0.0221 0.2601 0.2601
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Echinococcus granulosus suppressor of cytokine signaling 6 0.0221 0.2601 0.2601
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0216 0.0476
Echinococcus multilocularis dna polymerase eta 0.0075 0.0754 0.0754
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0483 0.0483
Schistosoma mansoni growth factor receptor-bound protein 0.0221 0.2601 0.2601
Schistosoma mansoni hypothetical protein 0.0478 0.5849 0.5849
Echinococcus multilocularis tyrosine kinase 0.0155 0.1768 0.1768
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0155 0.1768 0.3876
Echinococcus multilocularis tyrosine protein kinase 0.0155 0.1768 0.1768
Entamoeba histolytica serine/threonine kinase, putative 0.0155 0.1768 0.371
Brugia malayi STAT protein, DNA binding domain containing protein 0.0221 0.2601 0.5702
Leishmania major DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0243 0.0865
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0243 0.0243
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Onchocerca volvulus 0.0376 0.4563 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0155 0.1768 0.3741
Schistosoma mansoni tyrosine protein kinase 0.0155 0.1768 0.1768
Trypanosoma brucei protein kinase, putative 0.0155 0.1768 0.3973
Leishmania major hypothetical protein, conserved 0.0155 0.1768 0.3973
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Brugia malayi hypothetical protein 0.0042 0.0339 0.0743
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0206 0.0451
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0435 0.0757
Echinococcus granulosus lamin dm0 0.0031 0.0206 0.0206
Echinococcus multilocularis tyrosine protein kinase csk 0.0155 0.1768 0.1768
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.1065 0.5784
Echinococcus granulosus SH2 motif 0.0221 0.2601 0.2601
Loa Loa (eye worm) hypothetical protein 0.0058 0.0538 0.1179
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0155 0.1768 0.3876
Loa Loa (eye worm) SH2 domain-containing protein 0.0221 0.2601 0.5702
Echinococcus multilocularis tyrosine protein kinase Blk 0.0376 0.4563 0.4563
Schistosoma mansoni hypothetical protein 0.0056 0.052 0.052
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0376 0.4563 1
Trypanosoma brucei Flagellum attachment zone protein 20 0.0155 0.1768 0.3973
Echinococcus multilocularis tyrosine protein kinase Srms 0.0376 0.4563 0.4563
Loa Loa (eye worm) TK protein kinase 0.0155 0.1768 0.3876
Entamoeba histolytica SH2 domain containing protein 0.0221 0.2601 0.5585
Brugia malayi Tyrosine-protein kinase abl-1 0.0376 0.4563 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0376 0.4563 0.4563
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0155 0.1768 0.1768
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Loa Loa (eye worm) TK/FER protein kinase 0.0376 0.4563 1
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Brugia malayi SET domain containing protein 0.0015 0.0001 0.0003
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0155 0.1768 0.371
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0376 0.4563 0.4563
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0243 0.0243
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Schistosoma mansoni hypothetical protein 0.0097 0.1031 0.1031
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0155 0.1768 1
Trypanosoma brucei unspecified product 0.0031 0.0201 0.0192
Schistosoma mansoni hypothetical protein 0.0042 0.0339 0.0339
Schistosoma mansoni intermediate filament proteins 0.0031 0.0206 0.0206
Echinococcus multilocularis tumor protein p63 0.0395 0.4798 0.4798
Brugia malayi hypothetical protein 0.0155 0.1768 0.3876
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0027 0.0017
Echinococcus multilocularis musashi 0.0031 0.0206 0.0206
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0155 0.1768 0.3876
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0155 0.1768 0.1768
Echinococcus granulosus epidermal growth factor receptor 0.0155 0.1768 0.1768
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0243 0.0295
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0155 0.1768 0.3876
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0836 0.1989
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Giardia lamblia Kinase, NEK 0.0155 0.1768 0.4116
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0376 0.4563 0.4563
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0221 0.2601 0.2601
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0377 0.087
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0704 0.241
Schistosoma mansoni tyrosine kinase 0.0376 0.4563 0.4563
Entamoeba histolytica hypothetical protein, conserved 0.0155 0.1768 0.371
Schistosoma mansoni importin beta-1 0.0034 0.0233 0.0233
Brugia malayi tRNA modification GTPase TrmE family protein 0.0221 0.2601 0.5702
Echinococcus granulosus insulin receptor 0.0155 0.1768 0.1768
Entamoeba histolytica hypothetical protein 0.0155 0.1768 0.371
Onchocerca volvulus 0.0155 0.1768 0.3741
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0121 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.1768 0.426
Echinococcus granulosus snurportin 1 0.036 0.4354 0.4354
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0155 0.1768 0.3973
Brugia malayi Variant SH3 domain containing protein 0.0221 0.2601 0.5702
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0704 0.1407
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0221 0.2601 0.2601
Entamoeba histolytica hypothetical protein 0.0155 0.1768 0.371
Brugia malayi SH2 domain containing protein 0.0221 0.2601 0.5702
Loa Loa (eye worm) TK/Met protein kinase 0.0155 0.1768 0.3876
Schistosoma mansoni protein tyrosine kinase 0.0155 0.1768 0.1768
Loa Loa (eye worm) TK protein kinase 0.0155 0.1768 0.3876
Brugia malayi Immunoglobulin I-set domain containing protein 0.0155 0.1768 0.3876
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0221 0.2601 0.5585
Loa Loa (eye worm) SRC-1 0.0376 0.4563 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Loa Loa (eye worm) STAT protein 0.0221 0.2601 0.5702
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0155 0.1768 0.371
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.1768 0.426
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0221 0.2601 0.2601
Echinococcus granulosus protein tyrosine kinase 0.0155 0.1768 0.1768
Loa Loa (eye worm) TK protein kinase 0.0155 0.1768 0.3876
Onchocerca volvulus 0.0221 0.2601 0.5607
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Loa Loa (eye worm) TK/ALK protein kinase 0.0155 0.1768 0.3876
Schistosoma mansoni tyrosine kinase 0.0376 0.4563 0.4563
Schistosoma mansoni hypothetical protein 0.0221 0.2601 0.2601
Brugia malayi intermediate filament protein 0.0031 0.0206 0.0451
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0227 0.2675 0.8837
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0243 0.5
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0361 0.1455
Brugia malayi Furin-like cysteine rich region family protein 0.0155 0.1768 0.3876
Onchocerca volvulus 0.0221 0.2601 0.5607
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0221 0.2601 0.2601
Echinococcus multilocularis lamin dm0 0.0031 0.0206 0.0206
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.052 0.1139
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0221 0.2601 0.5702
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0243 0.0295
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Plasmodium falciparum tyrosine kinase-like protein 0.0155 0.1768 1
Entamoeba histolytica tyrosin kinase, putative 0.0155 0.1768 0.371
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0045 0.0377 0.0377
Loa Loa (eye worm) TK protein kinase 0.0155 0.1768 0.3876
Onchocerca volvulus 0.0277 0.3315 0.7206
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Brugia malayi hypothetical protein 0.0023 0.0099 0.0216
Schistosoma mansoni protein kinase 0.0155 0.1768 0.1768
Echinococcus granulosus SH2 domain containing adapter protein F 0.0221 0.2601 0.2601
Schistosoma mansoni growth factor receptor-bound protein 0.0221 0.2601 0.2601
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0377 0.0702
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.022 0.2584 0.2584
Schistosoma mansoni ran 0.0025 0.0121 0.0121
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.0538 0.0538
Echinococcus granulosus tyrosine protein kinase HCK 0.0155 0.1768 0.1768
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Echinococcus granulosus tyrosine protein kinase Lyn 0.0376 0.4563 0.4563
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0206 0.0451
Echinococcus multilocularis raf serine:threonine protein kinase 0.0155 0.1768 0.1768
Echinococcus multilocularis RUN 0.0023 0.0099 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.4124 1
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0232 0.0232
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Onchocerca volvulus 0.0376 0.4563 1
Entamoeba histolytica protein kinase, putative 0.0221 0.2601 0.5585
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0099 0.0099
Schistosoma mansoni GTPase activating protein 0.0221 0.2601 0.2601
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0155 0.1768 0.1768
Loa Loa (eye worm) TK/INSR protein kinase 0.0155 0.1768 0.3876
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0155 0.1768 0.3973
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0384 0.0887
Echinococcus granulosus tyrosine kinase 0.0376 0.4563 0.4563
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0377 0.0619
Entamoeba histolytica hypothetical protein 0.0155 0.1768 0.371
Schistosoma mansoni tyrosine kinase 0.0376 0.4563 0.4563
Brugia malayi Tyrosine-protein kinase PR2 0.0155 0.1768 0.3876
Echinococcus granulosus receptor type guanylyl cyclase 0.0155 0.1768 0.1768
Onchocerca volvulus 0.0036 0.026 0.0361
Schistosoma mansoni chromobox protein 0.0081 0.0836 0.0836
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Loa Loa (eye worm) hypothetical protein 0.0036 0.026 0.0569
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0155 0.1768 0.1768
Loa Loa (eye worm) hypothetical protein 0.0155 0.1768 0.3876
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0243 0.0295
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0243 0.0295
Giardia lamblia Kinase, NEK 0.0155 0.1768 0.4116
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0155 0.1768 0.3876
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0243 0.0533
Brugia malayi Protein kinase domain containing protein 0.0376 0.4563 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Echinococcus granulosus tyrosine kinase 0.0155 0.1768 0.1768
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Trichomonas vaginalis chromobox protein, putative 0.0081 0.0836 0.1989
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0704 0.0704
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0377 0.0377
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0155 0.1768 0.1768
Loa Loa (eye worm) SH2 domain-containing protein 0.0221 0.2601 0.5702
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0377 0.0702
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0221 0.2601 0.2601
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Onchocerca volvulus 0.0056 0.0512 0.0926
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Trichomonas vaginalis protein tyrosine kinase, putative 0.0155 0.1768 0.426
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0339 0.0339
Echinococcus multilocularis ephrin type A receptor 4 A 0.0155 0.1768 0.1768
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Echinococcus multilocularis N chimaerin 0.0221 0.2601 0.2601
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0121 0.0121
Loa Loa (eye worm) TK/FER protein kinase 0.0376 0.4563 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0243 0.0295
Echinococcus multilocularis protein KINase family member (kin 25) 0.0155 0.1768 0.1768
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0155 0.1768 0.3876
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0155 0.1768 0.426
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0243 0.0295
Echinococcus multilocularis SH2 motif 0.0221 0.2601 0.2601
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0221 0.2601 0.2601
Loa Loa (eye worm) TK/FER protein kinase 0.0376 0.4563 1
Entamoeba histolytica hypothetical protein 0.0155 0.1768 0.371
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0483 0.0483
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0155 0.1768 0.3973
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Brugia malayi Variant SH3 domain containing protein 0.0221 0.2601 0.5702
Schistosoma mansoni protein kinase 0.0155 0.1768 0.1768
Echinococcus granulosus activated cdc42 kinase 1 0.0155 0.1768 0.1768
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0704 0.241
Entamoeba histolytica hypothetical protein 0.0042 0.0339 0.0491
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0243 0.0742
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Onchocerca volvulus 0.0049 0.0426 0.0733
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0155 0.1768 0.426
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Echinococcus granulosus chromobox protein 1 0.0081 0.0836 0.0836
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Entamoeba histolytica hypothetical protein 0.0027 0.0153 0.0072
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0153 0.0323
Loa Loa (eye worm) hypothetical protein 0.0276 0.33 0.7233
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0377 0.0619
Loa Loa (eye worm) RGC/RGC protein kinase 0.0155 0.1768 0.3876
Entamoeba histolytica serine/threonine kinase, putative 0.0155 0.1768 0.371
Echinococcus multilocularis NCK adaptor protein 0.0221 0.2601 0.2601
Echinococcus multilocularis SH2 domain containing protein 7 0.0221 0.2601 0.2601
Trypanosoma cruzi protein kinase, putative 0.0155 0.1768 0.3973
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0376 0.4563 0.4563
Loa Loa (eye worm) hypothetical protein 0.0031 0.0198 0.0435
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.4124 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0483 0.1059
Schistosoma mansoni polycystin 1-related 0.0023 0.0099 0.0099
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0233 0.0271
Loa Loa (eye worm) hypothetical protein 0.0155 0.1768 0.3876
Brugia malayi Sex muscle abnormal protein 5 0.0221 0.2601 0.5702
Loa Loa (eye worm) TK protein kinase 0.0155 0.1768 0.3876
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0097 0.1031 0.2259
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0097 0.1031 0.2259
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0155 0.1768 0.1768
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0258 0.0258
Brugia malayi cytokine inducible SH2-containing protein 5 0.0221 0.2601 0.5702
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.4124 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0155 0.1768 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0155 0.1768 0.1768
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0258 0.0258
Brugia malayi hypothetical protein 0.0176 0.2039 0.447
Loa Loa (eye worm) TK/FER protein kinase 0.0376 0.4563 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0428 0.0738
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0221 0.2601 0.2601
Echinococcus multilocularis insulin receptor 0.0155 0.1768 0.1768
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Echinococcus granulosus chromobox protein 1 0.0081 0.0836 0.0836
Toxoplasma gondii protein kinase domain-containing protein 0.0155 0.1768 1
Echinococcus granulosus c src tyrosine kinase 0.0376 0.4563 0.4563
Loa Loa (eye worm) apoptosis regulator protein 0.0097 0.1031 0.2259
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0243 0.0295
Schistosoma mansoni shc transforming protein 0.0221 0.2601 0.2601
Echinococcus multilocularis 0.0221 0.2601 0.2601
Echinococcus multilocularis tyrosine protein kinase csk 0.0155 0.1768 0.1768
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0512 0.0512
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0243 0.0295
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0243 0.0865
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Loa Loa (eye worm) TK/FER protein kinase 0.0376 0.4563 1
Echinococcus multilocularis epidermal growth factor receptor 0.0155 0.1768 0.1768
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0376 0.4563 0.4563
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Mycobacterium tuberculosis Probable dehydrogenase 0.0227 0.2675 0.8837
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0377 0.087
Loa Loa (eye worm) mbt repeat family protein 0.0056 0.0512 0.1122
Trypanosoma cruzi protein kinase, putative 0.0155 0.1768 0.3973
Loa Loa (eye worm) hypothetical protein 0.0155 0.1768 0.3876
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Echinococcus multilocularis SHC transforming protein 3 0.0221 0.2601 0.2601
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0155 0.1768 0.371
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Echinococcus granulosus dnaJ subfamily B 0.0478 0.5849 0.5849
Echinococcus multilocularis FL cytokine receptor 0.0155 0.1768 0.1768
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0155 0.1768 0.1768
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0221 0.2601 0.5702
Loa Loa (eye worm) hypothetical protein 0.0155 0.1768 0.3876
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0377 0.0619
Schistosoma mansoni nck2/grb4 0.0221 0.2601 0.2601
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Echinococcus multilocularis cpg binding protein 0.0035 0.0256 0.0256
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0155 0.1768 0.1768
Echinococcus granulosus tyrosine kinase 0.0376 0.4563 0.4563
Onchocerca volvulus 0.0376 0.4563 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0353 0.4268 1
Schistosoma mansoni lamin 0.0031 0.0206 0.0206
Schistosoma mansoni protein kinase 0.0155 0.1768 0.1768
Echinococcus granulosus tyrosine protein kinase Src42A 0.0376 0.4563 0.4563
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0243 0.0295
Leishmania major importin beta-1 subunit, putative 0.0027 0.0153 0.0077
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0097 0.1031 0.1031
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0155 0.1768 0.1768
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0099 0.0099
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0072 0.0126
Loa Loa (eye worm) TK/FER protein kinase 0.0155 0.1768 0.3876
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1768 0.1768
Loa Loa (eye worm) TK protein kinase 0.0155 0.1768 0.3876
Onchocerca volvulus 0.0034 0.0232 0.0298
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0221 0.2601 0.5702
Brugia malayi protein-tyrosine kinase 0.0376 0.4563 1
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1768 0.1768
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0221 0.2601 0.2601
Schistosoma mansoni protein kinase 0.0155 0.1768 0.1768
Echinococcus multilocularis kinase suppressor of Ras 1 0.0155 0.1768 0.1768
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni rab6-interacting 0.0023 0.0099 0.0099
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0572 0.1087
Schistosoma mansoni ephrin receptor 0.0155 0.1768 0.1768
Loa Loa (eye worm) RGC/RGC protein kinase 0.0155 0.1768 0.3876
Loa Loa (eye worm) TK protein kinase 0.0155 0.1768 0.3876
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Echinococcus multilocularis tyrosine protein kinase pr2 0.0155 0.1768 0.1768
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni tensin 0.0221 0.2601 0.2601
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0243 0.0295
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Brugia malayi Variant SH3 domain containing protein 0.0221 0.2601 0.5702
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0244 0.2891 0.6336
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0155 0.1768 0.1768
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0155 0.1768 0.371
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0243 0.0543
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni signal transduction protein lnk-related 0.0221 0.2601 0.2601
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0221 0.2601 0.5702
Echinococcus multilocularis tyrosine protein kinase shark 0.0376 0.4563 0.4563
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Brugia malayi Thioredoxin reductase 0.0099 0.1065 0.2333
Echinococcus multilocularis snurportin 1 0.036 0.4354 0.4354
Brugia malayi CXXC zinc finger family protein 0.0034 0.0232 0.0508
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0155 0.1768 0.371
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0376 0.4563 0.4563
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0167 0.1916 0.8742
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0097 0.1031 0.1031
Schistosoma mansoni lipoxygenase 0.0023 0.0099 0.0099
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0252 0.2995 1
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni tensin 0.0221 0.2601 0.2601
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0155 0.1768 0.371
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0376 0.4563 0.4563
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.1768 0.426
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0258 0.0258
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0227 0.2675 0.8837
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0155 0.1768 0.1768
Echinococcus granulosus protein kinase 0.0155 0.1768 0.1768
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Echinococcus granulosus tyrosine protein kinase csk 0.0155 0.1768 0.1768
Schistosoma mansoni cpg binding protein 0.0035 0.0256 0.0256
Loa Loa (eye worm) TK/RYK protein kinase 0.0155 0.1768 0.3876
Loa Loa (eye worm) TK protein kinase 0.0376 0.4563 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0341 0.4124 1
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0221 0.2601 0.2601
Leishmania major mitochondrial DNA polymerase beta 0.0353 0.4268 1
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0155 0.1768 0.1768
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0097 0.1031 0.1031
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0221 0.2601 0.2601
Entamoeba histolytica hypothetical protein 0.0155 0.1768 0.371
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0376 0.4563 0.4563
Trypanosoma brucei unspecified product 0.0045 0.0377 0.0619
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0155 0.1768 0.1768
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0341 0.4124 0.9013
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0243 0.0295
Plasmodium vivax tyrosine kinase-like protein, putative 0.0155 0.1768 1
Giardia lamblia Kinase 0.0155 0.1768 0.4116
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0097 0.1031 0.1031
Echinococcus multilocularis tyrosine protein kinase HCK 0.0155 0.1768 0.1768
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0435 0.0757
Echinococcus granulosus dna polymerase eta 0.0075 0.0754 0.0754
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0097 0.1031 0.1031
Loa Loa (eye worm) hypothetical protein 0.0036 0.0258 0.0565
Echinococcus granulosus tyrosine protein kinase Src42A 0.0221 0.2601 0.2601
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Schistosoma mansoni hypothetical protein 0.0339 0.409 0.409
Brugia malayi SRC-1 0.0376 0.4563 1
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0233 0.0233
Echinococcus multilocularis epidermal growth factor receptor 0.0155 0.1768 0.1768
Schistosoma mansoni hypothetical protein 0.036 0.4354 0.4354
Echinococcus multilocularis protein kinase 0.0155 0.1768 0.1768
Entamoeba histolytica tyrosin kinase, putative 0.0155 0.1768 0.371
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0155 0.1768 0.1768
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0339 0.0339
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0155 0.1768 0.426
Echinococcus multilocularis SH2 motif 0.0221 0.2601 0.2601
Plasmodium falciparum protein kinase, putative 0.0155 0.1768 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0155 0.1768 0.3973
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Echinococcus granulosus dna polymerase kappa 0.0045 0.0377 0.0377
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0155 0.1768 0.1768
Echinococcus multilocularis SAM and MBT domain containing protein 0.0056 0.0512 0.0512
Schistosoma mansoni hypothetical protein 0.0221 0.2601 0.2601
Echinococcus granulosus tensin 0.0221 0.2601 0.2601
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Plasmodium falciparum thioredoxin reductase 0.0034 0.0243 0.0865
Entamoeba histolytica tyrosin kinase, putative 0.0155 0.1768 0.371
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0221 0.2601 0.2601
Echinococcus granulosus growth factor receptor bound protein 2 0.0221 0.2601 0.2601
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0483 0.0483
Echinococcus multilocularis lamin 0.0031 0.0206 0.0206
Echinococcus granulosus natriuretic peptide receptor 1 0.0155 0.1768 0.1768
Echinococcus granulosus endonuclease exonuclease phosphatase 0.022 0.2584 0.2584
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0339 0.0339
Echinococcus granulosus tyrosine protein kinase Srms 0.0376 0.4563 0.4563
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0072 0.0126
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Entamoeba histolytica hypothetical protein 0.0155 0.1768 0.371
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0155 0.1768 0.1768
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0227 0.2675 0.8837
Echinococcus granulosus expressed conserved protein 0.0221 0.2601 0.2601
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0201 0.0192
Echinococcus granulosus tyrosine protein kinase ABL1 0.0376 0.4563 0.4563
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0609 0.1336
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0376 0.4563 0.4563
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Brugia malayi Variant SH3 domain containing protein 0.0221 0.2601 0.5702
Brugia malayi SH2 domain containing protein 0.0376 0.4563 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0252 0.2995 1
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni tensin-related 0.0221 0.2601 0.2601
Loa Loa (eye worm) hypothetical protein 0.0031 0.0206 0.0451
Giardia lamblia DINP protein human, muc B family 0.0045 0.0377 0.0641
Loa Loa (eye worm) hypothetical protein 0.0023 0.0099 0.0216
Brugia malayi Pre-SET motif family protein 0.0036 0.0258 0.0565
Mycobacterium tuberculosis Probable reductase 0.0227 0.2675 0.8837
Echinococcus granulosus cpg binding protein 0.0035 0.0256 0.0256
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0155 0.1768 0.371
Plasmodium falciparum glutathione reductase 0.0034 0.0243 0.0865
Schistosoma mansoni protein kinase 0.0155 0.1768 0.1768
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0155 0.1768 0.1768
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Brugia malayi SH2 domain containing protein 0.0221 0.2601 0.5702
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Onchocerca volvulus 0.0058 0.0538 0.0984
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0155 0.1768 0.1768
Mycobacterium tuberculosis Probable oxidoreductase 0.0252 0.2995 1
Loa Loa (eye worm) heterochromatin protein 1 0.0081 0.0836 0.1833
Brugia malayi bone morphogenetic protein type 1 receptor 0.0155 0.1768 0.3876
Echinococcus multilocularis signal transduction protein lnk realted 0.0221 0.2601 0.2601
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0045 0.0377 0.0377
Trypanosoma brucei DNA polymerase eta, putative 0.0075 0.0754 0.1526
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0155 0.1768 0.3876
Echinococcus multilocularis protein kinase 0.0155 0.1768 0.1768
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0704 0.0704
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0377 0.0827
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0754 0.1652
Echinococcus multilocularis tyrosine kinase 0.0376 0.4563 0.4563
Schistosoma mansoni survival motor neuron protein 0.0056 0.052 0.052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0072 0.0126
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0099 0.0099
Entamoeba histolytica serine/threonine kinase, putative 0.0155 0.1768 0.371
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0155 0.1768 0.371
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0072 0.0126
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Loa Loa (eye worm) TK/ACK protein kinase 0.0155 0.1768 0.3876
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0221 0.2601 0.5607
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.0435 0.0757
Entamoeba histolytica hypothetical protein 0.0155 0.1768 0.371
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Trichomonas vaginalis TK family protein kinase 0.0155 0.1768 0.426
Echinococcus granulosus SH2 domain containing protein 7 0.0221 0.2601 0.2601
Echinococcus granulosus activin receptor type 0.0155 0.1768 0.1768
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0258 0.0258
Loa Loa (eye worm) TK/ABL protein kinase 0.0376 0.4563 1
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Loa Loa (eye worm) hypothetical protein 0.0056 0.0512 0.1122
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0056 0.0512 0.0512
Onchocerca volvulus 0.0031 0.0206 0.024
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0376 0.4563 0.4563
Mycobacterium ulcerans hypothetical protein 0.0186 0.2157 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0072 0.0126
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Schistosoma mansoni protein kinase 0.0155 0.1768 0.1768
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Brugia malayi Doublecortin family protein 0.0023 0.0099 0.0216
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.0243 0.5
Echinococcus multilocularis tensin 0.0221 0.2601 0.2601
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Plasmodium falciparum protein kinase, putative 0.0155 0.1768 1
Trichomonas vaginalis STE family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni ran 0.0025 0.0121 0.0121
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0428 0.0993
Loa Loa (eye worm) hypothetical protein 0.0075 0.0754 0.1652
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0127 0.0279
Schistosoma mansoni cpg binding protein 0.0035 0.0256 0.0256
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Schistosoma mansoni lamin 0.0031 0.0206 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Brugia malayi mbt repeat family protein 0.0056 0.0512 0.1122
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni hypothetical protein 0.0155 0.1768 0.1768
Echinococcus granulosus tyrosine protein kinase Fyn 0.0376 0.4563 0.4563
Loa Loa (eye worm) TK protein kinase 0.0155 0.1768 0.3876
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Brugia malayi C-terminal src kinase protein 1 0.0155 0.1768 0.3876
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0353 0.4268 1
Onchocerca volvulus 0.0155 0.1768 0.3741
Loa Loa (eye worm) hypothetical protein 0.0155 0.1768 0.3876
Echinococcus granulosus retinal guanylyl cyclase 2 0.0155 0.1768 0.1768
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Loa Loa (eye worm) hypothetical protein 0.0023 0.0099 0.0216
Entamoeba histolytica deoxycytidyl transferase, putative 0.0045 0.0377 0.0578
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0384 0.064
Trypanosoma cruzi DNA polymerase eta, putative 0.0075 0.0754 0.1526
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Loa Loa (eye worm) hypothetical protein 0.0221 0.2601 0.5702
Loa Loa (eye worm) TK/FER protein kinase 0.0376 0.4563 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0049 0.0426 0.0426
Entamoeba histolytica receptor protein kinase, putative 0.0155 0.1768 0.371
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0377 0.0489
Loa Loa (eye worm) TK/ROR protein kinase 0.0155 0.1768 0.3876
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0153 0.0077
Entamoeba histolytica serine/threonine kinase, putative 0.0155 0.1768 0.371
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0221 0.2601 0.2601
Entamoeba histolytica ankyrin repeat protein 0.0155 0.1768 0.371
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Onchocerca volvulus 0.0221 0.2601 0.5607
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0155 0.1768 0.371
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0099 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0155 0.1768 0.371
Echinococcus multilocularis activated cdc42 kinase 1 0.0155 0.1768 0.1768
Echinococcus granulosus tumor protein p63 0.0395 0.4798 0.4798
Trichomonas vaginalis conserved hypothetical protein 0.0155 0.1768 0.426
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0243 0.0295
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Schistosoma mansoni apoptosis regulator bax 0.0097 0.1031 0.1031
Echinococcus granulosus retinal guanylyl cyclase 2 0.0155 0.1768 0.1768
Loa Loa (eye worm) SH2 domain-containing protein 0.0221 0.2601 0.5702
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0045 0.0377 0.0377
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0072 0.0126
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0155 0.1768 0.1768
Schistosoma mansoni tensin 0.0221 0.2601 0.2601
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0512 0.0512
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0221 0.2601 0.2601
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0121 0.0265
Entamoeba histolytica ankyrin repeat protein 0.0155 0.1768 0.371
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0704 0.0704
Echinococcus granulosus tyrosine protein kinase Fyn 0.0376 0.4563 0.4563
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0377 0.0619
Echinococcus granulosus raf serine:threonine protein kinase 0.0155 0.1768 0.1768
Loa Loa (eye worm) TK/FER protein kinase 0.0155 0.1768 0.3876
Trypanosoma brucei unspecified product 0.0031 0.0201 0.0192
Brugia malayi integrin-linked kinase 0.0155 0.1768 0.3876
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0227 0.2675 0.8837
Plasmodium falciparum glutathione reductase 0.0099 0.1065 0.5784
Brugia malayi Protein kinase domain containing protein 0.0376 0.4563 1
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Onchocerca volvulus 0.0376 0.4563 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0155 0.1768 0.371
Echinococcus granulosus SH2 motif 0.0221 0.2601 0.2601
Schistosoma mansoni microtubule-associated protein tau 0.0806 1 1
Schistosoma mansoni loxhd1 0.0023 0.0099 0.0099
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0609 0.0609
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0376 0.4563 0.4563
Schistosoma mansoni SH2A 0.0221 0.2601 0.2601
Leishmania major DNA polymerase eta, putative 0.0075 0.0754 0.1526
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0353 0.4268 1
Echinococcus granulosus importin subunit beta 1 0.0034 0.0233 0.0233
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0155 0.1768 0.1768
Echinococcus multilocularis tyrosine protein kinase csk 0.0155 0.1768 0.1768
Echinococcus multilocularis transfer RNA-Thr 0.0155 0.1768 0.1768
Loa Loa (eye worm) TK/FER protein kinase 0.0376 0.4563 1
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0233 0.0682
Brugia malayi Receptor family ligand binding region containing protein 0.0155 0.1768 0.3876
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0155 0.1768 0.371
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0121 0.0265
Schistosoma mansoni serine/threonine RGC 0.0155 0.1768 0.1768
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0483 0.0483
Entamoeba histolytica tyrosine kinase, putative 0.0155 0.1768 0.371
Echinococcus granulosus signal transduction protein lnk realted 0.0221 0.2601 0.2601
Schistosoma mansoni protein kinase 0.0155 0.1768 0.1768
Echinococcus granulosus SAM and MBT domain containing protein 0.0056 0.0512 0.0512
Echinococcus multilocularis dnaJ subfamily B 0.0478 0.5849 0.5849
Entamoeba histolytica hypothetical protein 0.0155 0.1768 0.371
Echinococcus multilocularis natriuretic peptide receptor 1 0.0155 0.1768 0.1768
Loa Loa (eye worm) TK/FER protein kinase 0.0155 0.1768 0.3876
Schistosoma mansoni protein kinase 0.0155 0.1768 0.1768
Brugia malayi chromobox protein homolog 3 0.0046 0.0384 0.0842
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0704 0.0704
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0221 0.2601 0.2601
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0155 0.1768 0.3741
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Echinococcus granulosus epidermal growth factor receptor 0.0155 0.1768 0.1768
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0609 0.0609
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0121 0.0121
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Entamoeba histolytica protein kinase, putative 0.0155 0.1768 0.371
Schistosoma mansoni hypothetical protein 0.0023 0.0099 0.0099
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Trypanosoma brucei trypanothione reductase 0.0099 0.1065 0.2275
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0099 0.0216
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0704 0.3541
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0155 0.1768 0.3876
Schistosoma mansoni terminal deoxycytidyl transferase 0.0045 0.0377 0.0377
Brugia malayi Heterochromatin protein 1 0.0081 0.0836 0.1833
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0155 0.1768 0.1768
Brugia malayi Importin beta-1 subunit 0.0034 0.0233 0.0511
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Entamoeba histolytica protein kinase domain containing protein 0.0155 0.1768 0.371
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1768 0.1768
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0377 0.0489
Schistosoma mansoni cpg binding protein 0.0034 0.0232 0.0232
Echinococcus granulosus survival motor neuron protein 1 0.0276 0.33 0.33
Schistosoma mansoni tyrosine kinase 0.0155 0.1768 0.1768
Brugia malayi Protein kinase domain containing protein 0.0376 0.4563 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0376 0.4563 0.4563
Giardia lamblia Protein 21.1 0.0155 0.1768 0.4116
Loa Loa (eye worm) TK/FER protein kinase 0.0155 0.1768 0.3876
Echinococcus granulosus tyrosine protein kinase csk 0.0155 0.1768 0.1768
Schistosoma mansoni protein kinase 0.0155 0.1768 0.1768
Leishmania major trypanothione reductase 0.0099 0.1065 0.2275
Plasmodium falciparum thioredoxin reductase 0.0099 0.1065 0.5784
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0155 0.1768 0.1768
Entamoeba histolytica serine/threonine kinase, putative 0.0155 0.1768 0.371
Echinococcus granulosus tyrosine protein kinase Src64B 0.0376 0.4563 0.4563
Loa Loa (eye worm) hypothetical protein 0.0155 0.1768 0.3876
Brugia malayi hypothetical protein 0.0276 0.33 0.7233
Trichomonas vaginalis TKL family protein kinase 0.0155 0.1768 0.426
Brugia malayi Protein kinase domain containing protein 0.0376 0.4563 1
Schistosoma mansoni tensin-related 0.0221 0.2601 0.2601
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0167 0.1919 0.4335
Entamoeba histolytica serine/threonine kinase, putative 0.0155 0.1768 0.371
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0221 0.2601 0.5702
Brugia malayi Protein kinase domain containing protein 0.0155 0.1768 0.3876
Schistosoma mansoni protein kinase 0.0155 0.1768 0.1768
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0155 0.1768 1
Echinococcus granulosus RUN 0.0023 0.0099 0.0099
Trichomonas vaginalis set domain proteins, putative 0.0277 0.3315 0.8029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0243 0.0295

Activities

Activity type Activity value Assay description Source Reference
Log EC50 (functional) 0 Evaluated for K-ATP activity in terms of stable twitch response through field-stimulated landrace pig detrusor assay ChEMBL. 15163196
Log EC50 (functional) < 5 Evaluated for K-ATP activity in terms of change in membrane potential through guinea pig bladder assay ChEMBL. 15163196

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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