Detailed information for compound 1775724

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 268.354 | Formula: C17H20N2O
  • H donors: 1 H acceptors: 2 LogP: 2.71 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccccc1CN1CCCC[C@H]1c1cccnc1
  • InChi: 1S/C17H20N2O/c20-17-9-2-1-6-15(17)13-19-11-4-3-8-16(19)14-7-5-10-18-12-14/h1-2,5-7,9-10,12,16,20H,3-4,8,11,13H2/t16-/m0/s1
  • InChiKey: QKGCWXDVBXIISA-INIZCTEOSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans glutamate synthase subunit beta 0.0074 0.0248 0.2386
Trypanosoma brucei Heat shock protein 83, putative 0.0055 0.018 0.0153
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0074 0.0248 0.1849
Toxoplasma gondii hypothetical protein 0.1495 0.5406 1
Brugia malayi heat shock protein 90 0.0055 0.018 0.018
Trypanosoma cruzi Heat shock protein 83, putative 0.0055 0.018 0.0153
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0074 0.0248 0.0221
Brugia malayi hypothetical protein 0.001 0.0016 0.0016
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Plasmodium falciparum heat shock protein 90 0.0055 0.018 0.0303
Mycobacterium ulcerans DNA gyrase subunit B 0.0055 0.018 0.1688
Mycobacterium tuberculosis Conserved protein 0.0041 0.0129 0.0395
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0055 0.018 0.0571
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0129 0.0395
Treponema pallidum NADH oxidase 0.0278 0.0989 1
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.018 0.128
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0278 0.0989 0.0964
Brugia malayi hypothetical protein 0.0006 0.0002 0.0002
Echinococcus granulosus geminin 0.0387 0.1385 0.1385
Mycobacterium ulcerans two component regulator - sensor kinase 0.0055 0.018 0.1688
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0022 0.0022
Leishmania major DNA topoisomerase ii 0.0055 0.018 0.0153
Brugia malayi Animal haem peroxidase family protein 0.0484 0.1737 0.1737
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0074 0.0248 0.0248
Plasmodium falciparum endoplasmin, putative 0.0055 0.018 0.0303
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0401 0.1436 0.2633
Loa Loa (eye worm) endoplasmin 0.0055 0.018 0.018
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0055 0.018 0.1688
Trichomonas vaginalis esterase, putative 0.0041 0.0129 0.1168
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0016
Onchocerca volvulus Peroxidasin homolog 0.0484 0.1737 0.9988
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0074 0.0248 0.0807
Mycobacterium ulcerans putative regultory protein 0.0055 0.018 0.1688
Mycobacterium ulcerans beta-lactamase 0.0041 0.0129 0.1168
Schistosoma mansoni heat shock protein 0.0055 0.018 0.018
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0055 0.018 0.0153
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0278 0.0989 0.1803
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0278 0.0989 0.0989
Echinococcus multilocularis carbonic anhydrase 0.1495 0.5406 0.5406
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0017 0.0017
Leishmania major hypothetical protein, conserved 0.0074 0.0248 0.0221
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0278 0.0989 0.0989
Mycobacterium tuberculosis Conserved protein 0.0041 0.0129 0.0395
Onchocerca volvulus Dual oxidase homolog 0.0484 0.1737 0.9988
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0017
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0129 0.0129
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0022 0.0022
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0022 0.0022
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0002 0.0002
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0022 0.0022
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0074 0.0248 0.0248
Trichomonas vaginalis receptor histidine kinase, putative 0.0055 0.018 0.1688
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.0989 0.0964
Echinococcus granulosus carbonic anhydrase 0.1495 0.5406 0.5406
Brugia malayi Animal haem peroxidase family protein 0.0484 0.1737 0.1737
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0254 0.0227
Loa Loa (eye worm) heat shock protein 90 0.0055 0.018 0.018
Onchocerca volvulus Protein cereblon homolog 0.0342 0.122 0.7012
Schistosoma mansoni peroxidasin 0.0484 0.1737 0.1737
Loa Loa (eye worm) hypothetical protein 0.0484 0.1737 0.1737
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0074 0.0248 0.2386
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0074 0.0248 0.0429
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.0248 0.0429
Loa Loa (eye worm) programmed cell death 8 0.0074 0.0248 0.0248
Plasmodium vivax DNA gyrase subunit B, putative 0.0055 0.018 0.0491
Trypanosoma brucei NADH dehydrogenase 0.0074 0.0248 0.0221
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0022
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0074 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0041 0.0129 0.0129
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0074 0.0248 0.0248
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0278 0.0989 0.0964
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.018 0.0153
Mycobacterium tuberculosis Conserved protein 0.0055 0.018 0.0571
Plasmodium vivax thioredoxin reductase, putative 0.0802 0.289 1
Loa Loa (eye worm) hypothetical protein 0.0484 0.1737 0.1737
Trichomonas vaginalis glutamate synthase, putative 0.0074 0.0248 0.2386
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0129 0.0129
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0069 0.0069
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0055 0.018 0.1688
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0074 0.0248 0.0839
Plasmodium falciparum DNA gyrase subunit B 0.0055 0.018 0.0303
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0074 0.0248 0.1378
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0248 0.0221
Loa Loa (eye worm) hypothetical protein 0.001 0.0016 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.0989 0.0964
Trichomonas vaginalis mercuric reductase, putative 0.0278 0.0989 1
Mycobacterium ulcerans dehydrogenase 0.0074 0.0248 0.2386
Leishmania major hypothetical protein, conserved 0.0074 0.0248 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0074 0.0248 0.1378
Echinococcus multilocularis carbonic anhydrase 0.1495 0.5406 0.5406
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0278 0.0989 0.0964
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0022 0.0022
Brugia malayi Peroxidasin 0.0484 0.1737 0.1737
Onchocerca volvulus 0.0484 0.1737 0.9988
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0248 0.0221
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0017 0.0017
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0055 0.018 0.0571
Schistosoma mansoni glutamate synthase 0.0074 0.0248 0.0248
Schistosoma mansoni coup transcription factor 0.0012 0.0022 0.0022
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0074 0.0248 0.1849
Loa Loa (eye worm) hypothetical protein 0.0041 0.0129 0.0129
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.018 0.0153
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0055 0.018 0.018
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0129 0.1168
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0055 0.018 0.1035
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1495 0.5406 0.5406
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0022 0.0022
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0074 0.0248 0.2386
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0248 0.2386
Brugia malayi Animal haem peroxidase family protein 0.0484 0.1737 0.1737
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0022 0.0022
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0055 0.018 0.1035
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0022 0.0022
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0027 0.012
Trypanosoma brucei developmentally regulated phosphoprotein 0.099 0.3572 0.3554
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.018 0.0153
Loa Loa (eye worm) animal heme peroxidase 0.0484 0.1737 0.1737
Loa Loa (eye worm) hypothetical protein 0.0484 0.1737 0.1737
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0278 0.0989 0.0964
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0022 0.0022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.0989 0.0964
Schistosoma mansoni thyroid hormone receptor 0.0155 0.0544 0.0544
Mycobacterium tuberculosis Probable oxidoreductase 0.0278 0.0989 0.3384
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0002 0.0002
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0248 0.0221
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0055 0.018 0.0153
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0139 0.0139
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0017 0.000000000030851
Schistosoma mansoni carbonic anhydrase 0.1495 0.5406 0.5406
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0022 0.0022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0022 0.0022
Echinococcus granulosus heat shock protein 0.0055 0.018 0.018
Onchocerca volvulus Peroxidasin homolog 0.0485 0.1739 1
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0017 0.0017
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0074 0.0248 0.0221
Loa Loa (eye worm) hypothetical protein 0.1495 0.5406 0.5406
Mycobacterium tuberculosis Possible two component sensor kinase 0.0055 0.018 0.0571
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0129 0.0129
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0248 0.2386
Plasmodium vivax glutathione reductase, putative 0.0802 0.289 1
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0055 0.018 0.0588
Loa Loa (eye worm) hypothetical protein 0.0484 0.1737 0.1737
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0074 0.0248 0.0248
Trypanosoma cruzi trypanothione reductase, putative 0.0802 0.289 0.2871
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0022 0.0022
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0002 0.0002
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0129 0.1168
Treponema pallidum oxidoreductase 0.0074 0.0248 0.0839
Brugia malayi Probable DNA topoisomerase II 0.0055 0.018 0.018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0022 0.0022
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0074 0.0248 0.0248
Brugia malayi glutamate synthase 0.0074 0.0248 0.0248
Mycobacterium ulcerans two component sensor kinase MprB 0.0055 0.018 0.1688
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0022
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0055 0.018 0.0571
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0022
Entamoeba histolytica hypothetical protein, conserved 0.0342 0.122 1
Loa Loa (eye worm) hypothetical protein 0.0484 0.1737 0.1737
Loa Loa (eye worm) hypothetical protein 0.0041 0.0129 0.0129
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0022 0.0022
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0055 0.018 0.0303
Brugia malayi kinase, mitochondrial precursor 0.099 0.3572 0.3572
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0074 0.0248 0.0221
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0055 0.018 0.1688
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0144 0.0502 0.0502
Mycobacterium leprae Probable two-component sensor kinase 0.0055 0.018 0.0588
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0278 0.0989 0.0964
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0074 0.0248 0.2386
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0074 0.0248 0.2386
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Giardia lamblia Thioredoxin reductase 0.0074 0.0248 0.2386
Echinococcus multilocularis geminin 0.0387 0.1385 0.1385
Onchocerca volvulus 0.0074 0.0248 0.1425
Trypanosoma cruzi DNA topoisomerase II, putative 0.0055 0.018 0.0153
Echinococcus multilocularis heat shock protein 0.0055 0.018 0.018
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0129 0.1168
Giardia lamblia Glutamate synthase 0.0074 0.0248 0.2386
Giardia lamblia NADH oxidase lateral transfer candidate 0.0278 0.0989 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1495 0.5406 0.5406
Brugia malayi hypothetical protein 0.0139 0.0485 0.0485
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0022 0.0022
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0254 0.0254
Schistosoma mansoni DNA topoisomerase II 0.0055 0.018 0.018
Brugia malayi beta-lactamase family protein 0.0041 0.0129 0.0129
Entamoeba histolytica DNA topoisomerase II, putative 0.0055 0.018 0.128
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.0248 0.0429
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0074 0.0248 0.2386
Echinococcus granulosus carbonic anhydrase 0.1495 0.5406 0.5406
Loa Loa (eye worm) hypothetical protein 0.1495 0.5406 0.5406
Trypanosoma brucei heat shock protein, putative 0.0055 0.018 0.0153
Trypanosoma brucei heat shock protein, putative 0.0055 0.018 0.0153
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0022 0.0022
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0204 0.0721 0.0721
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0022 0.0022
Echinococcus multilocularis carbonic anhydrase 0.1495 0.5406 0.5406
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0022 0.0022
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0002 0.0002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0278 0.0989 0.0964
Trichomonas vaginalis glutamate synthase, putative 0.0074 0.0248 0.2386
Trypanosoma brucei trypanothione reductase 0.0802 0.289 0.2871
Loa Loa (eye worm) hypothetical protein 0.0484 0.1737 0.1737
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0248 0.2386
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0055 0.018 0.1688
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0074 0.0248 0.0729
Mycobacterium ulcerans ferredoxin reductase 0.0074 0.0248 0.2386
Brugia malayi Protein kinase domain containing protein 0.0062 0.0205 0.0205
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0055 0.018 0.0153
Trypanosoma cruzi trypanothione reductase, putative 0.0278 0.0989 0.0964
Brugia malayi beta-lactamase 0.0041 0.0129 0.0129
Mycobacterium tuberculosis Probable reductase 0.0074 0.0248 0.0807
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0278 0.0989 0.1803
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0278 0.0989 1
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0074 0.0248 0.0807
Leishmania major hypothetical protein, conserved 0.0055 0.018 0.0153
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0278 0.0989 0.1803
Schistosoma mansoni pyruvate dehydrogenase 0.0935 0.3372 0.3372
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0129 0.1168
Echinococcus multilocularis protein cereblon 0.0342 0.122 0.122
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0002 0.0002
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0055 0.018 0.0571
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1495 0.5406 0.5406
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1495 0.5406 0.5406
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0055 0.018 0.1688
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0022 0.0022
Schistosoma mansoni glutamate synthase 0.0074 0.0248 0.0248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0022 0.0022
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0074 0.0248 0.0729
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0022 0.0022
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Brugia malayi hypothetical protein 0.0342 0.122 0.122
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0278 0.0989 1
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0055 0.018 0.0571
Trichomonas vaginalis glutathione reductase, putative 0.0278 0.0989 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0074 0.0248 0.0248
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.2761 1 1
Schistosoma mansoni hypothetical protein 0.0342 0.122 0.122
Echinococcus multilocularis peroxidasin 0.0484 0.1737 0.1737
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0346 0.1236 0.1212
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0022 0.0022
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0074 0.0248 0.0221
Plasmodium falciparum glutathione reductase 0.0278 0.0989 0.1803
Trypanosoma brucei DNA topoisomerase ii 0.0055 0.018 0.0153
Schistosoma mansoni carbonic anhydrase-related 0.1495 0.5406 0.5406
Leishmania major mitochondrial DNA topoisomerase II 0.0055 0.018 0.0153
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0022
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0074 0.0248 0.0248
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0055 0.018 0.0153
Schistosoma mansoni carbonic anhydrase-related 0.1495 0.5406 0.5406
Onchocerca volvulus 0.0041 0.0129 0.0744
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0129 0.1168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0022
Schistosoma mansoni DNA helicase recq1 0.001 0.0017 0.0017
Schistosoma mansoni pyruvate dehydrogenase 0.0935 0.3372 0.3372
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.099 0.3572 0.3572
Onchocerca volvulus 0.0484 0.1737 0.9988
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0263 0.0934 0.3193
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0022 0.0022
Leishmania major developmentally regulated phosphoprotein-like protein 0.099 0.3572 0.3554
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0022 0.0127
Echinococcus granulosus protein cereblon 0.0342 0.122 0.122
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0022 0.0022
Mycobacterium leprae Probable two component sensor kinase MprB 0.0055 0.018 0.0588
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0055 0.018 0.018
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0022 0.0022
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0278 0.0989 1
Mycobacterium ulcerans hypothetical protein 0.0041 0.0129 0.1168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0022
Onchocerca volvulus Peroxidase homolog 0.0484 0.1737 0.9988
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.2761 1 1
Toxoplasma gondii selenide, water dikinase 0.0074 0.0248 0.0429
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0055 0.018 0.1688
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0074 0.0248 0.2386
Trypanosoma cruzi DNA topoisomerase II, putative 0.0055 0.018 0.0153
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0022 0.0022
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0022 0.0022
Brugia malayi Putative carbonic anhydrase 5 precursor 0.2761 1 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0254 0.0254
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0129 0.1168
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0022 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0039 0.0042
Loa Loa (eye worm) animal heme peroxidase 0.0484 0.1737 0.1737
Loa Loa (eye worm) hypothetical protein 0.0041 0.0129 0.0129
Mycobacterium tuberculosis Probable two component sensor kinase 0.0055 0.018 0.0571
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0022 0.0022
Trypanosoma brucei heat shock protein, putative 0.0055 0.018 0.0153
Loa Loa (eye worm) hypothetical protein 0.0055 0.018 0.018
Schistosoma mansoni hypothetical protein 0.0387 0.1385 0.1385
Plasmodium falciparum ferrodoxin reductase-like protein 0.0074 0.0248 0.0429
Schistosoma mansoni hypothetical protein 0.0074 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0055 0.018 0.018
Loa Loa (eye worm) thioredoxin reductase 0.0802 0.289 0.289
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.0989 0.0964
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0074 0.0248 0.0248
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0129 0.0395
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0041 0.0129 0.0129
Plasmodium falciparum thioredoxin reductase 0.0278 0.0989 0.1803
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0278 0.0989 0.3328
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0022 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0055 0.018 0.0491
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0055 0.018 0.1688
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1495 0.5406 0.5406
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0074 0.0248 0.2386
Loa Loa (eye worm) hypothetical protein 0.1495 0.5406 0.5406
Trichomonas vaginalis DNA topoisomerase II, putative 0.0055 0.018 0.1688
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0248 0.0221
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0278 0.0989 0.3384
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0022 0.0022
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0017 0.0017
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0074 0.0248 0.0248
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0017 0.0017
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0055 0.018 0.1688
Loa Loa (eye worm) animal heme peroxidase 0.0484 0.1737 0.1737
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0074 0.0248 0.0807
Onchocerca volvulus Peroxidase homolog 0.0484 0.1737 0.9988
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Brugia malayi glutathione reductase 0.0802 0.289 0.289
Echinococcus granulosus bloom syndrome protein 0.0024 0.0069 0.0069
Mycobacterium ulcerans lipase LipD 0.0041 0.0129 0.1168
Entamoeba histolytica disulphide oxidoreductase, putative 0.0074 0.0248 0.1849
Brugia malayi Thioredoxin reductase 0.0802 0.289 0.289
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0062 0.0205 0.0205
Loa Loa (eye worm) RecQ helicase 0.0024 0.0069 0.0069
Plasmodium falciparum thioredoxin reductase 0.0802 0.289 0.5332
Loa Loa (eye worm) blistered cuticle protein 3 0.0484 0.1737 0.1737
Loa Loa (eye worm) hypothetical protein 0.0484 0.1737 0.1737
Echinococcus multilocularis heat shock protein 90 0.0055 0.018 0.018
Trypanosoma cruzi NADH dehydrogenase, putative 0.0074 0.0248 0.0221
Trypanosoma brucei heat shock protein, putative 0.0055 0.018 0.0153
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0074 0.0248 0.0807
Brugia malayi Animal haem peroxidase family protein 0.0484 0.1737 0.1737
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0074 0.0248 0.0839
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0055 0.018 0.1688
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0346 0.1236 0.1212
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0055 0.018 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0022 0.0022
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0074 0.0248 0.0807
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0278 0.0989 0.3384
Schistosoma mansoni hypothetical protein 0.0387 0.1385 0.1385
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.005 0.005
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0017 0.0017
Toxoplasma gondii heat shock protein HSP90 0.0055 0.018 0.0303
Schistosoma mansoni pyruvate dehydrogenase 0.099 0.3572 0.3572
Loa Loa (eye worm) hypothetical protein 0.0342 0.122 0.122
Chlamydia trachomatis thioredoxin reductase 0.0074 0.0248 0.0839
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0022 0.0022
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0129 0.0314
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0058 0.0076
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0278 0.0989 1
Trichomonas vaginalis endoplasmin, putative 0.0055 0.018 0.1688
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0074 0.0248 0.2386
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0278 0.0989 0.3328
Brugia malayi Endoplasmin precursor 0.0055 0.018 0.018
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0074 0.0248 0.0429
Brugia malayi ecdysteroid receptor 0.0012 0.0022 0.0022
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0278 0.0989 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0022 0.0022
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.2761 1 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0278 0.0989 0.3384
Echinococcus granulosus carbonic anhydrase II 0.2761 1 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0055 0.018 0.0571
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0074 0.0248 0.0221
Loa Loa (eye worm) hypothetical protein 0.0484 0.1737 0.1737
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0022 0.0022
Brugia malayi hypothetical protein 0.0006 0.0002 0.0002
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0278 0.0989 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0074 0.0248 0.0248
Schistosoma mansoni sulfide quinone reductase 0.0074 0.0248 0.0248
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0062 0.0206 0.0206
Trichomonas vaginalis apoptosis inducing factor, putative 0.0074 0.0248 0.2386
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0074 0.0248 0.0807
Plasmodium falciparum carbonic anhydrase 0.1495 0.5406 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0022 0.0127
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0055 0.018 0.1688
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0278 0.0989 0.0989
Onchocerca volvulus 0.0012 0.0022 0.0127
Loa Loa (eye worm) hypothetical protein 0.0362 0.1295 0.1295
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0254 0.0254
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0129 0.0395
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0074 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0484 0.1737 0.1737
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0074 0.0248 0.0807
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.018 0.0153
Trichomonas vaginalis heat shock protein, putative 0.0055 0.018 0.1688
Leishmania major carbonic anhydrase-like protein 0.2761 1 1
Loa Loa (eye worm) hypothetical protein 0.0484 0.1737 0.1737
Plasmodium vivax heat shock protein 86, putative 0.0055 0.018 0.0491
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0129 0.0102
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0069 0.0543
Plasmodium vivax ferrodoxin reductase, putative 0.0074 0.0248 0.0729
Echinococcus granulosus heat shock protein 90 0.0055 0.018 0.018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0129 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0129 0.0102
Schistosoma mansoni disulfide oxidoreductase 0.0074 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0074 0.0248 0.0248
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0055 0.018 0.0571
Entamoeba histolytica thioredoxin reductase, putative 0.0074 0.0248 0.1849
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0248 0.2386
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0139 0.0139
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0055 0.018 0.0571
Plasmodium vivax DNA topoisomerase II, putative 0.0055 0.018 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0022 0.0022
Toxoplasma gondii DNA topoisomerase 2, putative 0.0055 0.018 0.0303
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0055 0.018 0.1688
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.018 0.0153
Trypanosoma brucei carbonic anhydrase-like protein 0.2761 1 1
Onchocerca volvulus Chorion peroxidase homolog 0.0484 0.1737 0.9988
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0055 0.018 0.0588
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0069 0.0543
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0074 0.0248 0.1849
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0254 0.0254
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0022 0.0022
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0802 0.289 1
Brugia malayi beta-lactamase family protein 0.0041 0.0129 0.0129
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Trichomonas vaginalis heat shock protein, putative 0.0055 0.018 0.1688
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0055 0.018 0.0153
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0074 0.0248 0.2386
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0051
Schistosoma mansoni endoplasmin 0.0055 0.018 0.018
Treponema pallidum thioredoxin reductase (trxB) 0.0074 0.0248 0.0839
Plasmodium falciparum glutathione reductase 0.0802 0.289 0.5332
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0129 0.1168
Loa Loa (eye worm) carbonic anhydrase 3 0.2761 1 1
Schistosoma mansoni carbonic anhydrase-related 0.1495 0.5406 0.5406
Echinococcus multilocularis thioredoxin glutathione reductase 0.0802 0.289 0.289
Mycobacterium ulcerans monoxygenase 0.0074 0.0248 0.2386
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.0989 0.0964
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0074 0.0248 0.1849
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0278 0.0989 0.0989
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0074 0.0248 0.1378
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0129 0.0395
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0074 0.0248 0.0429
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0346 0.1236 0.1212
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.1495 0.5406 0.5406
Mycobacterium tuberculosis Conserved protein 0.0041 0.0129 0.0395
Trypanosoma brucei heat shock protein, putative 0.0055 0.018 0.0153
Echinococcus granulosus peroxidasin 0.0484 0.1737 0.1737
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0074 0.0248 0.0248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0484 0.1737 0.1737
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.099 0.3572 0.3572
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0022 0.0022
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0022 0.0022
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0055 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0484 0.1737 0.1737
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0074 0.0248 0.1849
Leishmania major NADH dehydrogenase, putative 0.0074 0.0248 0.0221
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0017 0.0017
Loa Loa (eye worm) glutathione reductase 0.0802 0.289 0.289
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0144 0.0502 0.0502
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.001 0.0016 0.0091
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0204 0.0721 0.0721
Onchocerca volvulus 0.0041 0.0129 0.0744
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0022 0.0022
Echinococcus granulosus carbonic anhydrase 0.1495 0.5406 0.5406
Schistosoma mansoni hypothetical protein 0.0144 0.0502 0.0502
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0022 0.0127
Brugia malayi nuclear receptor NHR-88 0.0012 0.0022 0.0022
Leishmania major hypothetical protein, conserved 0.0041 0.0129 0.0102
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0346 0.1236 0.2262
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0022
Echinococcus multilocularis glutamate synthase 0.0074 0.0248 0.0248
Leishmania major hypothetical protein, conserved 0.0074 0.0248 0.0221
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.099 0.3572 0.3554
Trichomonas vaginalis sensor histidine kinase, putative 0.0055 0.018 0.1688
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0055 0.018 0.018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0278 0.0989 0.0964
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0248 0.0221
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0055 0.018 0.0303
Echinococcus granulosus thioredoxin glutathione reductase 0.0802 0.289 0.289
Brugia malayi Sulfatase family protein 0.001 0.0016 0.0016
Brugia malayi nuclear receptor RXR 0.0006 0.0002 0.0002
Schistosoma mansoni glutamate synthase 0.0074 0.0248 0.0248
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0254 0.1899
Trypanosoma brucei heat shock protein 90, putative 0.0055 0.018 0.0153
Giardia lamblia Heat shock protein HSP 90-alpha 0.0055 0.018 0.1688
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0055 0.018 0.1688
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0074 0.0248 0.2386
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0248 0.0221
Brugia malayi steroid hormone receptor 0.0012 0.0022 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0129 0.0102
Schistosoma mansoni peroxidasin 0.0484 0.1737 0.1737
Loa Loa (eye worm) TOPoisomerase family member 0.0055 0.018 0.018
Schistosoma mansoni sulfide quinone reductase 0.0074 0.0248 0.0248
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0254 0.0227
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0055 0.018 0.1035
Echinococcus multilocularis carbonic anhydrase II 0.2761 1 1
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0074 0.0248 0.0839
Mycobacterium ulcerans NADH dehydrogenase 0.0074 0.0248 0.2386
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0062 0.0205 0.0205
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0248 0.2386
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0278 0.0989 1
Trypanosoma brucei heat shock protein, putative 0.0055 0.018 0.0153
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0002 0.0002
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0074 0.0248 0.0429
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.018 0.0153
Onchocerca volvulus 0.0041 0.0129 0.0744
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0484 0.1737 0.1737
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0254 0.0227
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0055 0.018 0.0571
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.2761 1 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0278 0.0989 0.0964
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0074 0.0248 0.0248
Schistosoma mansoni DNA helicase recq5 0.001 0.0017 0.0017
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0055 0.018 0.0571
Onchocerca volvulus 0.0484 0.1737 0.9988
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0022 0.0022
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0074 0.0248 0.1378
Brugia malayi hypothetical protein 0.0484 0.1737 0.1737
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0074 0.0248 0.0248
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0278 0.0989 0.0964
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0278 0.0989 0.0964
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0074 0.0248 0.0807
Toxoplasma gondii ABC1 family protein 0.0041 0.0129 0.0209
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0254 0.0227
Toxoplasma gondii thioredoxin reductase 0.0802 0.289 0.5332
Brugia malayi Animal haem peroxidase family protein 0.0484 0.1737 0.1737
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0055 0.018 0.0571
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0074 0.0248 0.2386
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0022 0.0022
Trichomonas vaginalis receptor histidine kinase, putative 0.0055 0.018 0.1688
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Trypanosoma brucei heat shock protein, putative 0.0055 0.018 0.0153
Schistosoma mansoni endoplasmin 0.0055 0.018 0.018
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0129 0.0395
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0022
Trypanosoma cruzi NADH dehydrogenase, putative 0.0074 0.0248 0.0221
Trypanosoma brucei heat shock protein, putative 0.0055 0.018 0.0153
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0278 0.0989 0.0964
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0265 0.094 0.094
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0022 0.0022
Mycobacterium ulcerans hypothetical protein 0.0074 0.0248 0.2386
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0022 0.0022
Loa Loa (eye worm) animal heme peroxidase 0.0484 0.1737 0.1737
Plasmodium falciparum DNA topoisomerase 2 0.0055 0.018 0.0303
Toxoplasma gondii NADPH-glutathione reductase 0.0278 0.0989 0.1803
Brugia malayi nuclear hormone receptor 0.0012 0.0022 0.0022
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.2761 1 1
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0074 0.0248 0.0429
Mycobacterium tuberculosis Probable dehydrogenase 0.0074 0.0248 0.0807
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0129 0.0129
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0129 0.0395
Echinococcus granulosus glutamate synthase 0.0074 0.0248 0.0248
Schistosoma mansoni heat shock protein 0.0055 0.018 0.018
Brugia malayi Blistered cuticle protein 3 0.0484 0.1737 0.1737
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0022 0.0022
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0074 0.0248 0.2386
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0254 0.0254
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0022 0.0022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0022 0.0022
Giardia lamblia Pms1-like protein 0.0055 0.018 0.1688
Leishmania major trypanothione reductase 0.0802 0.289 0.2871
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.0544 0.0544
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.099 0.3572 0.3572
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0055 0.018 0.0303
Loa Loa (eye worm) hypothetical protein 0.0484 0.1737 0.1737
Loa Loa (eye worm) hypothetical protein 0.099 0.3572 0.3572
Schistosoma mansoni thyroid hormone receptor 0.0155 0.0544 0.0544
Entamoeba histolytica heat shock protein 90, putative 0.0055 0.018 0.128
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0074 0.0248 0.0807
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0074 0.0248 0.2386
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0074 0.0248 0.0221
Plasmodium vivax endoplasmin, putative 0.0055 0.018 0.0491
Toxoplasma gondii heat shock protein 90, putative 0.0055 0.018 0.0303
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0074 0.0248 0.1378
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0074 0.0248 0.0807
Loa Loa (eye worm) hypothetical protein 0.0041 0.0129 0.0129
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0074 0.0248 0.0221
Brugia malayi follicle stimulating hormone receptor 0.0265 0.094 0.094
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1495 0.5406 0.5406
Leishmania major heat shock protein 83-1 0.0055 0.018 0.0153
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0129 0.0395
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0002 0.0002
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0055 0.018 0.1688
Loa Loa (eye worm) beta-lactamase 0.0041 0.0129 0.0129
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0074 0.0248 0.0221
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0074 0.0248 0.0248

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 6.7 uM Inhibition of LPS-induced nitric oxide production in human BV2 cells after 24 hrs by spectrophotometry ChEMBL. 23734721

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 23734721

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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