Detailed information for compound 1779134

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 452.503 | Formula: C24H28N4O5
  • H donors: 3 H acceptors: 4 LogP: 2.25 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(cc(cc1C(C)(C)C)N1CCC(=O)NC1=O)C(=O)Nc1ccc(cc1)NC(=O)C
  • InChi: 1S/C24H28N4O5/c1-14(29)25-15-6-8-16(9-7-15)26-22(31)18-12-17(28-11-10-20(30)27-23(28)32)13-19(21(18)33-5)24(2,3)4/h6-9,12-13H,10-11H2,1-5H3,(H,25,29)(H,26,31)(H,27,30,32)
  • InChiKey: IEXFCUDJCHEQIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi jmjC domain containing protein 0.0016 0.0051 0.0661
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0177
Mycobacterium ulcerans hypothetical protein 0.1498 1 1
Brugia malayi jmjC domain containing protein 0.0016 0.0051 0.0661
Loa Loa (eye worm) hypothetical protein 0.1498 1 1
Echinococcus granulosus ferritin 0.0017 0.0061 0.0059
Schistosoma mansoni cpg binding protein 0.0057 0.0325 0.0325
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0342 0.0341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0013
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0051 0.005
Entamoeba histolytica diacylglycerol kinase, putative 0.0058 0.0337 0.0271
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.0665 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0015 0.0013
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0191 0.019
Schistosoma mansoni hypothetical protein 0.0031 0.0157 0.0157
Schistosoma mansoni ferritin 0.0017 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0065
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0067 0.0568
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0267 0.0266
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0055 0.0312 0.0311
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0051 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0107 0.14
Echinococcus granulosus Diacylglycerol kinase theta 0.0058 0.0337 0.0336
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0053 0.0052
Plasmodium vivax diacylglycerol kinase, putative 0.0058 0.0337 1
Schistosoma mansoni sphingoid long chain base kinase 0.1498 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0157 0.0156
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0312 0.0311
Brugia malayi mbt repeat family protein 0.0048 0.0267 0.3503
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0013
Toxoplasma gondii diacylglycerol kinase, putative 0.0058 0.0337 0.4658
Echinococcus multilocularis GPCR, family 2 0.0031 0.0157 0.0156
Mycobacterium ulcerans hypothetical protein 0.0024 0.0107 0.0047
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0058 0.0337 0.0336
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0053 0.0074
Schistosoma mansoni ferritin 0.0017 0.0061 0.0061
Echinococcus multilocularis geminin 0.0172 0.1102 0.1101
Echinococcus granulosus cpg binding protein 0.006 0.0347 0.0346
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0267 0.0266
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0013
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.1237 0.1236
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0177
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0053 0.0074
Loa Loa (eye worm) hypothetical protein 0.0048 0.0267 0.0266
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0015 0.0015
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0107 0.0054
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0067 0.5
Brugia malayi jmjC domain containing protein 0.0016 0.0051 0.0661
Loa Loa (eye worm) hypothetical protein 0.0058 0.0337 0.0336
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0067 0.0875
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0267 0.0267
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0067 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0053 0.0052
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0107 0.004
Schistosoma mansoni hypothetical protein 0.0172 0.1102 0.1102
Leishmania major sphingosine kinase A, B, putative 0.0058 0.0337 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0107 0.0047
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0058 0.0337 1
Brugia malayi jmjC domain containing protein 0.0059 0.0342 0.4489
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0053 0.0035
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0058 0.0337 0.0336
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0062 0.0796
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0342 0.0341
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0267 0.7827
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0053 0.0052
Echinococcus granulosus biogenic amine 5HT receptor 0.0132 0.0833 0.0832
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0157 0.0156
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0058 0.0337 0.0337
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0312 0.0311
Schistosoma mansoni biogenic amine (5HT) receptor 0.0398 0.262 0.262
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0015 0.0013
Onchocerca volvulus 0.0057 0.0325 0.9634
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0013
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0342 0.0341
Loa Loa (eye worm) hypothetical protein 0.0099 0.0613 0.0612
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0067 0.1175
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0066 0.0006
Mycobacterium tuberculosis Conserved protein 0.1498 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0013
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0061 0.0007
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0053 0.0052
Schistosoma mansoni smad 0.0008 0.0001 0.0001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0015 0.0015
Brugia malayi Ceramide kinase 0.0058 0.0337 0.4426
Entamoeba histolytica diacylglycerol kinase, putative 0.0058 0.0337 0.0271
Schistosoma mansoni Smad4 0.0008 0.0001 0.0001
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.5204 0.5203
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.006 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.006 0.0007
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0066 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.0337 0.0336
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0053 0.0052
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0051 0.005
Trypanosoma cruzi Sphingosine kinase 0.0058 0.0337 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0073 0.0072
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0013
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0157 0.0156
Loa Loa (eye worm) hypothetical protein 0.0132 0.0833 0.0832
Onchocerca volvulus 0.0024 0.0107 0.2878
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0051 0.005
Schistosoma mansoni hypothetical protein 0.0037 0.0191 0.0191
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0267 0.0266
Brugia malayi steroid hormone receptor 0.001 0.0015 0.0177
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.076 0.0759
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0107 0.1963
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0053 0.0074
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0066 0.0532
Brugia malayi MH2 domain containing protein 0.0121 0.076 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0067 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0015 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.0751 0.0751
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.076 0.0759
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0063 0.0062
Echinococcus multilocularis Diacylglycerol kinase theta 0.0058 0.0337 0.0336
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0107 0.0047
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0013
Echinococcus multilocularis dnaJ subfamily B 0.0806 0.5355 0.5354
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0067 0.0568
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0015 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0015 0.0177
Trichomonas vaginalis diacylglycerol kinase, putative 0.0058 0.0337 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0107 0.1963
Trichomonas vaginalis bmru protein, putative 0.0058 0.0337 1
Schistosoma mansoni hypothetical protein 0.0031 0.0157 0.0157
Trypanosoma cruzi diacylglycerol kinase, putative 0.0058 0.0337 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0106
Schistosoma mansoni coup transcription factor 0.001 0.0015 0.0015
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0051 0.005
Brugia malayi Eye-specific diacylglycerol kinase 0.0058 0.0337 0.4426
Echinococcus granulosus geminin 0.0172 0.1102 0.1101
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0106
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0364 0.0363
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0015 0.0013
Schistosoma mansoni ap endonuclease 0.0018 0.0067 0.0067
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0107 0.0047
Brugia malayi jmjC domain containing protein 0.0062 0.0364 0.4774
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0015 0.0013
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0107 0.0047
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0015 0.0013
Echinococcus granulosus Diacylglycerol kinase zeta 0.0058 0.0337 0.0336
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0058 0.0337 0.0337
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0013
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0267 0.0266
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0015 0.0015
Leishmania major hypothetical protein, conserved 0.0058 0.0337 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0013
Leishmania major diacylglycerol kinase, putative 0.0058 0.0337 1
Echinococcus multilocularis serotonin receptor 0.0132 0.0833 0.0832
Echinococcus multilocularis ferritin 0.0017 0.0061 0.0059
Brugia malayi Diacylglycerol kinase protein 2 0.0058 0.0337 0.4426
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0058 0.0337 0.0336
Trichomonas vaginalis sphingosine kinase, putative 0.0058 0.0337 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0015 0.0177
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0067 0.0568
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0051 0.0051
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0053 0.0689
Echinococcus granulosus GPCR family 2 0.0031 0.0157 0.0156
Schistosoma mansoni ferritin 0.0017 0.0061 0.0061
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0051 0.005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0015 0.0015
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0157 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0177
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0058 0.0337 1
Brugia malayi ecdysteroid receptor 0.001 0.0015 0.0177
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0058 0.0337 1
Schistosoma mansoni hypothetical protein 0.0058 0.0337 0.0337
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0066 0.0532
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0013
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.004 0.0039
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0312 0.0311
Schistosoma mansoni smad1 5 8 and 0.0008 0.0001 0.0001
Brugia malayi nuclear hormone receptor 0.001 0.0015 0.0177
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0053 0.0052
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0058 0.0337 0.4658
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0053 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0013
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0058 0.0337 0.0336
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0053 0.0074
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0067 0.1175
Plasmodium falciparum diacylglycerol kinase, putative 0.0058 0.0337 1
Trypanosoma brucei hypothetical protein, conserved 0.0058 0.0337 1
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0058 0.0337 0.4658
Schistosoma mansoni apoferritin-2 0.0017 0.0061 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0177
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0067 0.0014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0613 0.8055
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0053 0.0074
Loa Loa (eye worm) diacylglycerol kinase 2 0.0058 0.0337 0.0336
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0067 0.0066
Trypanosoma cruzi Sphingosine kinase 0.0058 0.0337 1
Brugia malayi hypothetical protein 0.0037 0.0191 0.2503
Schistosoma mansoni hypothetical protein 0.0172 0.1102 0.1102
Brugia malayi nuclear receptor NHR-88 0.001 0.0015 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0013
Schistosoma mansoni hypothetical protein 0.0068 0.0402 0.0402
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0058 0.0337 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0132 0.0833 0.0833
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0015 0.0015
Plasmodium vivax diacylglycerol kinase, putative 0.0058 0.0337 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0031 0.0157 0.0157
Loa Loa (eye worm) ceramide kinase 0.0058 0.0337 0.0336
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0191 0.0191
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0191 0.019
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0267 0.0267
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0067 0.0568
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0107 0.14
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0015 0.0177
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0398 0.262 0.2619
Onchocerca volvulus 0.0048 0.0267 0.7827
Schistosoma mansoni diacylglycerol kinase theta 0.0058 0.0337 0.0337
Echinococcus multilocularis sphingosine kinase 1 0.1498 1 1
Brugia malayi mbt repeat family protein 0.0048 0.0267 0.3503
Brugia malayi hypothetical protein 0.0058 0.0337 0.4426
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0001 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0015 0.0177
Entamoeba histolytica hypothetical protein 0.0037 0.0191 0.0124
Leishmania major diacylglycerol kinase-like protein 0.0058 0.0337 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0613 0.0612
Trypanosoma cruzi diacylglycerol kinase, putative 0.0058 0.0337 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0063 0.0062
Brugia malayi diacylglycerol kinase 0.0058 0.0337 0.4426
Trypanosoma brucei Sphingosine kinase 0.0058 0.0337 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0067 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0364 0.0363
Loa Loa (eye worm) hypothetical protein 0.0024 0.0107 0.0106
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0402 0.5275
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0067 0.0568
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0312 0.4089
Echinococcus granulosus biogenic amine 5HT receptor 0.0398 0.262 0.2619
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0065
Echinococcus multilocularis serotonin receptor 0.0132 0.0833 0.0832
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0015 0.0015
Trichomonas vaginalis ferritin, putative 0.0017 0.0061 0.0948
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0015 0.0177
Loa Loa (eye worm) hypothetical protein 0.0068 0.0402 0.0401
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0058 0.0337 1
Trichomonas vaginalis sphingosine kinase, putative 0.0058 0.0337 1
Schistosoma mansoni ap endonuclease 0.0018 0.0067 0.0067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.006 0.0007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0053 0.0052
Brugia malayi diacylglycerol kinase 0.0058 0.0337 0.4426
Schistosoma mansoni ferritin light chain 0.0017 0.0061 0.0061
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0325 0.0324
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0107 0.1963
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.004 0.0039
Leishmania major hypothetical protein, conserved 0.0058 0.0337 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0107 1
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0051 0.0051
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0058 0.0337 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0015 0.0013
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0342 0.0342
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0107 0.004
Echinococcus granulosus ceramide kinase 0.0058 0.0337 0.0336
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0061 0.0007
Schistosoma mansoni smad1 5 8 and 0.0008 0.0001 0.0001
Entamoeba histolytica hypothetical protein, conserved 0.1498 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0337 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0053 0.0074
Entamoeba histolytica diacylglycerol kinase, putative 0.0058 0.0337 0.0271
Schistosoma mansoni cpg binding protein 0.006 0.0347 0.0347
Echinococcus granulosus expressed protein 0.0017 0.0061 0.0059
Trichomonas vaginalis bmru protein, putative 0.0058 0.0337 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0013
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0157 0.0156
Toxoplasma gondii exonuclease III APE 0.0018 0.0067 0.0265
Mycobacterium ulcerans diacylglycerol kinase 0.0058 0.0337 0.0278
Brugia malayi isocitrate dehydrogenase 0.0016 0.0053 0.0689
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.006 0.0007
Schistosoma mansoni apoferritin-2 0.0017 0.0061 0.0061
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.1237 0.1236
Echinococcus multilocularis expressed protein 0.0017 0.0061 0.0059
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0067 0.0568
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0177
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0058 0.0337 0.0336
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0107 0.14
Plasmodium falciparum diacylglycerol kinase, putative 0.0058 0.0337 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0013
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0312 0.0312
Schistosoma mansoni cpg binding protein 0.006 0.0347 0.0347
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0337 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0015 0.0015
Echinococcus granulosus microtubule associated protein 2 0.0667 0.442 0.442
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0267 0.0266
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0157 0.2049
Echinococcus granulosus FTZ F1 alpha 0.001 0.0015 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0015 0.0177
Schistosoma mansoni smad1 5 8 and 0.0008 0.0001 0.0001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0364 0.0364
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0613 0.8055
Loa Loa (eye worm) hypothetical protein 0.0031 0.0157 0.0156
Onchocerca volvulus 0.0058 0.0337 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0053 0.0074
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0051 0.005
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0015 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0107 0.0054
Schistosoma mansoni hypothetical protein 0.0295 0.1925 0.1925
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0067 0.0066
Schistosoma mansoni nuclear hormone receptor 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0833 0.0832
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.442 0.442
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0051 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0013
Echinococcus multilocularis ceramide kinase 0.0058 0.0337 0.0336
Brugia malayi CXXC zinc finger family protein 0.0057 0.0325 0.427
Entamoeba histolytica hypothetical protein 0.0037 0.0191 0.0124
Brugia malayi jmjC domain containing protein 0.0016 0.0051 0.0661
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0107 0.0047
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0015 0.0013
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0015 0.0013
Echinococcus granulosus dnaJ subfamily B 0.0806 0.5355 0.5354
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0015 0.0013
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0067 0.0066
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0015 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0015 0.0177
Echinococcus granulosus phd:f box containing protein 0.0016 0.0051 0.005
Mycobacterium tuberculosis Diacylglycerol kinase 0.0058 0.0337 0.0285
Schistosoma mansoni hypothetical protein 0.0031 0.0157 0.0157
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0806 0.5355 0.5355
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0107 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0107 0.0047
Trichomonas vaginalis diacylglycerol kinase, putative 0.0058 0.0337 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0015 0.0015
Trypanosoma brucei diacylglycerol kinase, putative 0.0058 0.0337 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0107 0.004
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0015 0.0013
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0063 0.0062
Entamoeba histolytica hypothetical protein 0.0037 0.0191 0.0124
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0065
Schistosoma mansoni thyroid hormone receptor 0.001 0.0015 0.0015
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0058 0.0337 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0073 0.0072
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0066 0.0013
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0051 0.0051
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0015 0.0013
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0157 0.2049
Schistosoma mansoni ferritin light chain 0.0017 0.0061 0.0061
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.004 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0015 0.0177
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0015 0.0015
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0312 0.0311
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.442 0.442
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.004 0.0039
Schistosoma mansoni ferritin 0.0017 0.0061 0.0061
Schistosoma mansoni diacylglycerol kinase theta 0.0058 0.0337 0.0337
Onchocerca volvulus Ceramide kinase 1 homolog 0.0058 0.0337 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0015 0.0177
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0051 0.005
Entamoeba histolytica hypothetical protein 0.0037 0.0191 0.0124
Schistosoma mansoni sphingosine kinase A B 0.1498 1 1
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0051 0.005
Loa Loa (eye worm) MBCTL1 0.0055 0.0312 0.0311
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.005
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0267 0.0267
Entamoeba histolytica diacylglycerol kinase, putative 0.0058 0.0337 0.0271
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0107 1
Echinococcus multilocularis cpg binding protein 0.006 0.0347 0.0346

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.