Detailed information for compound 1785417

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 217.227 | Formula: C10H11N5O
  • H donors: 1 H acceptors: 3 LogP: 1.43 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1nc(/N=C/c2[nH]ccc2)nc(n1)C
  • InChi: 1S/C10H11N5O/c1-7-13-9(15-10(14-7)16-2)12-6-8-4-3-5-11-8/h3-6,11H,1-2H3/b12-6+
  • InChiKey: HDEYXSGJJFRUKH-WUXMJOGZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.003 0.0877 0.3338
Loa Loa (eye worm) hypothetical protein 0.0012 0.0275 0.0261
Schistosoma mansoni DNA polymerase eta 0.0061 0.1927 0.7414
Loa Loa (eye worm) hypothetical protein 0.0061 0.1927 0.1915
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.1076 0.4107
Trypanosoma cruzi phosphoglycerate kinase, putative 0.003 0.0877 0.3338
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0552 0.2079
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0275 0.1047
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0552 0.2079
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.1113 0.4248
Loa Loa (eye worm) hypothetical protein 0.0081 0.2599 0.2588
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0004 0.0015 0.0042
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.2241 0.8624
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.2241 0.8616
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0275 0.1047
Schistosoma mansoni synaptojanin 0.0004 0.0015 0.0056
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.027 0.9 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.073 0.2767
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0262 0.0956
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0646 0.2475
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0907 0.0893
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0908 0.3484
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.003 0.0877 0.3338
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0057 0.182 0.6985
Echinococcus granulosus bloom syndrome protein 0.0023 0.0646 0.0632
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0112 0.0416
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0552 0.0538
Treponema pallidum hypothetical protein 0.027 0.9 1
Echinococcus multilocularis muscleblind protein 0.03 1 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.004 0.0099
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0552 0.0538
Entamoeba histolytica phosphoglycerate kinase, putative 0.0081 0.2599 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0112 0.0416
Schistosoma mansoni cpg binding protein 0.0032 0.0965 0.3714
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0391 0.1458
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0112 0.0416
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.004 0.0099
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0197 0.0182
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.027 0.9 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.2241 0.223
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0552 0.0613
Leishmania major hypothetical protein, conserved 0.0012 0.0275 0.1009
Schistosoma mansoni synaptojanin 0.0004 0.0015 0.0056
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0197 0.0182
Loa Loa (eye worm) hypothetical protein 0.0011 0.0262 0.0247
Onchocerca volvulus 0.003 0.0907 0.9985
Leishmania major DNA polymerase kappa, putative 0.0011 0.0262 0.0956
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0026 0.0101
Schistosoma mansoni ap endonuclease 0.002 0.0552 0.2123
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.1113 0.4273
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0004 0.0015 0.0016
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0015 0.0056
Schistosoma mansoni phosphoglycerate kinase 0.0081 0.2599 1
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0004 0.0015 0.0056
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0196 0.07
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0275 0.1047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0112 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0112 0.0416
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0552 0.2123
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0275 0.0261
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0275 0.1009
Loa Loa (eye worm) hypothetical protein 0.0012 0.027 0.0256
Trichomonas vaginalis dullard protein, putative 0.0012 0.0275 0.1047
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0553 0.0614
Toxoplasma gondii aldehyde dehydrogenase 0.0057 0.182 0.6985
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0057 0.182 0.2009
Trypanosoma brucei phosphoglycerate kinase, putative 0.003 0.0877 0.3338
Entamoeba histolytica recQ family helicase, putative 0.0005 0.0034 0.0131
Trypanosoma cruzi DNA damage repair protein, putative 0.0011 0.0262 0.0956
Treponema pallidum ATP-dependent DNA helicase 0.0005 0.004 0.0028
Brugia malayi CXXC zinc finger family protein 0.003 0.0907 0.0893
Trypanosoma brucei phosphoglycerate kinase 0.0081 0.2599 1
Schistosoma mansoni hypothetical protein 0.0004 0.0015 0.0056
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.1113 0.4281
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0196 0.0181
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0004 0.0015 0.0042
Chlamydia trachomatis phosphoglycerate kinase 0.0081 0.2599 0.5
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1826 0.7009
Brugia malayi Phosphoglycerate kinase 0.003 0.0877 0.0864
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0012 0.0275 0.1009
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0004 0.0015 0.0042
Brugia malayi Ubiquitin-like protein SMT3 0.0049 0.1545 0.1533
Plasmodium vivax phosphoglycerate kinase, putative 0.0081 0.2599 0.2876
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.1113 0.4248
Schistosoma mansoni cpg binding protein 0.003 0.0907 0.3488
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0275 0.0261
Leishmania major phosphoglycerate kinase C, glycosomal 0.0081 0.2599 1
Giardia lamblia Phosphoglycerate kinase 0.0081 0.2599 1
Trypanosoma cruzi small ubiquitin protein, putative 0.0049 0.1545 0.5924
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0196 0.0181
Echinococcus granulosus phosphoglycerate kinase 1 0.0081 0.2599 0.2588
Trypanosoma brucei unspecified product 0.0025 0.073 0.2767
Treponema pallidum phosphoglycerate kinase 0.0081 0.2599 0.2876
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0004 0.0015 0.0056
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0275 0.106
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0081 0.2599 1
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0004 0.0015 0.0042
Echinococcus multilocularis 0.0012 0.0275 0.0261
Entamoeba histolytica ubiquitin like protein 0.0049 0.1545 0.5947
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0552 0.0598
Schistosoma mansoni cript-related 0.0004 0.0015 0.0056
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0015 0.0056
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0196 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0112 0.0416
Giardia lamblia DINP protein human, muc B family 0.0037 0.1113 0.4248
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0646 0.0632
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0552 0.0598
Trichomonas vaginalis Phospholipase C precursor, putative 0.0004 0.0015 0.0042
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.1113 0.1222
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0049 0.1545 0.5947
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.2241 0.8616
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.1113 0.11
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.2241 0.223
Schistosoma mansoni blooms syndrome DNA helicase 0.0005 0.004 0.0155
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0398 0.0426
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.182 0.7002
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.073 0.2767
Trypanosoma brucei phosphoglycerate kinase 0.0081 0.2599 1
Trypanosoma brucei unspecified product 0.0037 0.1113 0.4248
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0011 0.0262 0.0956
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.2059 0.7922
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0262 0.0956
Onchocerca volvulus 0.003 0.0908 1
Trichomonas vaginalis dullard protein, putative 0.0012 0.0275 0.1047
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.073 0.2767
Trichomonas vaginalis ubiquitin, putative 0.003 0.0908 0.3484
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0112 0.0416
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0289 0.1061
Loa Loa (eye worm) hypothetical protein 0.03 1 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.2241 0.8616
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.1113 0.11
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.182 0.1783
Trypanosoma brucei DNA polymerase eta, putative 0.0061 0.1927 0.7399
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0134 0.012
Schistosoma mansoni DNA helicase recq5 0.0009 0.0196 0.0752
Plasmodium vivax small ubiquitin-related modifier, putative 0.0049 0.1545 0.1704
Leishmania major DNA polymerase eta, putative 0.0035 0.1076 0.4107
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0262 0.0956
Echinococcus multilocularis cpg binding protein 0.0032 0.0965 0.0952
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.1113 0.11
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0112 0.0416
Echinococcus granulosus muscleblind protein 0.03 1 1
Echinococcus granulosus transcription factor Dp 1 0.004 0.1246 0.1233
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.1113 0.4248
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.1113 0.4273
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Leishmania major DNA polymerase eta, putative 0.0061 0.1927 0.7399
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0004 0.0015 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.1545 0.5941
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0004 0.0015 0.0056
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0037 0.1113 0.1222
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.1113 0.0974
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0015 0.0042
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0196 0.0217
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0485 0.1865
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.1113 0.11
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0005 0.0034 0.0022
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0004 0.0015 0.0056
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.182 0.1783
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0262 0.0956
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.027 0.9 1
Trypanosoma brucei unspecified product 0.0025 0.073 0.2767
Loa Loa (eye worm) hypothetical protein 0.0009 0.0196 0.0181
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0196 0.0181
Leishmania major phosphoglycerate kinase B, cytosolic 0.0081 0.2599 1
Echinococcus multilocularis Small ubiquitin modifier 2 0.0049 0.1545 0.1533
Trypanosoma brucei small ubiquitin-related modifier 0.0049 0.1545 0.5924
Echinococcus granulosus Small ubiquitin modifier 2 0.0049 0.1545 0.1533
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0134 0.012
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0196 0.0181
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0004 0.0004 0.00000000050329
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0057 0.182 0.1808
Loa Loa (eye worm) hypothetical protein 0.0005 0.004 0.0026
Plasmodium falciparum DNase I-like protein, putative 0.0004 0.0015 0.0016
Plasmodium falciparum DNA repair protein REV1, putative 0.0011 0.0262 0.0291
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0196 0.07
Trypanosoma brucei DNA damage repair protein, putative 0.0011 0.0262 0.0956
Schistosoma mansoni phosphoglycerate kinase 0.0081 0.2599 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0015 0.0056
Loa Loa (eye worm) hypothetical protein 0.03 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0004 0.0015 0.0056
Trypanosoma brucei phosphoglycerate kinase 0.003 0.0877 0.3338
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0193 0.0178
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0012 0.0275 0.1009
Echinococcus granulosus cpg binding protein 0.0032 0.0965 0.0952
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0646 0.0632
Echinococcus granulosus dna polymerase kappa 0.0037 0.1113 0.11
Echinococcus multilocularis dna polymerase eta 0.0061 0.1927 0.1915
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.027 0.9 1
Mycobacterium ulcerans phosphoglycerate kinase 0.0081 0.2599 0.2675
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.2241 0.223
Schistosoma mansoni hypothetical protein 0.0012 0.027 0.1041
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0015 0.0042
Leishmania major DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0081 0.2599 1
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0275 0.0261
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.1113 0.4248
Schistosoma mansoni DNA polymerase IV / kappa 0.0011 0.0262 0.1007
Echinococcus multilocularis dna polymerase kappa 0.0037 0.1113 0.11
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0081 0.2599 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0552 0.2079
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0196 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0112 0.0416
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0057 0.182 0.1808
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.2241 0.8616
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0197 0.0182
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0275 0.029
Plasmodium vivax DNA repair protein REV1, putative 0.0011 0.0262 0.0275
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0004 0.0015 0.0016
Plasmodium falciparum small ubiquitin-related modifier 0.0049 0.1545 0.1717
Trypanosoma cruzi phosphoglycerate kinase, putative 0.003 0.0877 0.3338
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0552 0.0538
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0004 0.0015 0.0016
Schistosoma mansoni ap endonuclease 0.002 0.0552 0.2123
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0112 0.0416
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.1113 0.4281
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0289 0.1098
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0012 0.0275 0.0306
Schistosoma mansoni carbon catabolite repressor protein 0.0004 0.0015 0.0056
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.2241 0.223
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0262 0.0956
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Toxoplasma gondii exonuclease III APE 0.002 0.0552 0.2079
Leishmania major small ubiquitin protein, putative 0.0049 0.1545 0.5924
Trichomonas vaginalis helicase, putative 0.0007 0.0112 0.0416
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.1113 0.0974
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0552 0.2112
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0289 0.1061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0112 0.0416
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.027 0.9 1
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0275 0.0261
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0275 0.106
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0081 0.2599 1
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0275 0.029
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0552 0.2112
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0112 0.0416
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0112 0.0416
Schistosoma mansoni neutral sphingomyelinase 0.0004 0.0015 0.0056
Trichomonas vaginalis dullard protein, putative 0.0012 0.0275 0.1047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0112 0.0416
Leishmania major DNA damage repair protein, putative 0.0011 0.0262 0.0956
Brugia malayi Phosphoglycerate kinase 0.0081 0.2599 0.2588
Loa Loa (eye worm) hypothetical protein 0.003 0.0908 0.0895
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.2241 0.8624
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Toxoplasma gondii small ubiquitin family modifier, putative 0.0049 0.1545 0.5924
Giardia lamblia Sentrin 0.0049 0.1545 0.5924
Brugia malayi polk-prov protein 0.0011 0.0262 0.0247
Schistosoma mansoni DNA helicase recq1 0.0009 0.0196 0.0752
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0011 0.0262 0.0956
Entamoeba histolytica recQ family DNA helicase 0.0005 0.004 0.0155
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0081 0.2599 1
Trypanosoma brucei DNA damage repair protein, putative 0.0011 0.0262 0.0956
Echinococcus multilocularis muscleblind protein 1 0.03 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0552 0.2079
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.003 0.0877 0.3338
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0112 0.0416
Echinococcus multilocularis phosphoglycerate kinase 1 0.0081 0.2599 0.2588
Echinococcus granulosus dna polymerase eta 0.0061 0.1927 0.1915
Brugia malayi hypothetical protein 0.003 0.0908 0.0895
Giardia lamblia DNA damage repair protein 0.0011 0.0262 0.0956
Loa Loa (eye worm) RecQ helicase 0.0023 0.0646 0.0632
Schistosoma mansoni nocturnin 0.0004 0.0015 0.0056
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0004 0.0015 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Echinococcus multilocularis transcription factor Dp 1 0.004 0.1246 0.1233
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0196 0.07
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0289 0.1111
Trypanosoma cruzi DNA polymerase eta, putative 0.0061 0.1927 0.7399
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.182 0.1783
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.1076 0.4107
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0289 0.1061
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0196 0.0181
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0646 0.2475
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0012 0.0275 0.1047
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0015 0.0056
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0004 0.0015 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0112 0.0416
Echinococcus granulosus ubiquitin 0.003 0.0908 0.0895
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0081 0.2599 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0134 0.012
Trypanosoma cruzi small ubiquitin protein, putative 0.0049 0.1545 0.5924
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0552 0.0332
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0012 0.0275 0.106
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1113 0.4248
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.1927 0.1915
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0134 0.012
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0015 0.0056
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0552 0.0598
Plasmodium falciparum phosphoglycerate kinase 0.0081 0.2599 0.2888
Schistosoma mansoni cpg binding protein 0.0032 0.0965 0.3714
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0004 0.0015 0.0056
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0081 0.2599 0.2876
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0012 0.0275 0.1009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0552 0.2079
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0081 0.2599 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.3741 0.3732
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0552 0.0538
Echinococcus multilocularis ubiquitin 0.003 0.0908 0.0895
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0134 0.0516
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.1113 0.4281
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0262 0.0956
Loa Loa (eye worm) SMO-1 protein 0.0049 0.1545 0.1533
Trypanosoma cruzi DNA damage repair protein, putative 0.0011 0.0262 0.0956
Entamoeba histolytica hypothetical protein 0.003 0.0908 0.3493
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.182 0.7002
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.003 0.0877 0.3338
Trypanosoma brucei chrX additional, unordered contigs 0.0011 0.0262 0.0956
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0004 0.0015 0.0042
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0112 0.0416
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0005 0.004 0.0099

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 25 ug ml-1 Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition after 5 days by microplate Alamar Blue assay ChEMBL. 24044875

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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