Detailed information for compound 17948

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 201.268 | Formula: C12H15N3
  • H donors: 2 H acceptors: 1 LogP: 1.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCc1c[nH]c(n1)Cc1ccccc1
  • InChi: 1S/C12H15N3/c13-7-6-11-9-14-12(15-11)8-10-4-2-1-3-5-10/h1-5,9H,6-8,13H2,(H,14,15)
  • InChiKey: FNAMDTWUDIOUON-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0071 0.0071
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Loa Loa (eye worm) hypothetical protein 0.0248 0.3761 0.3761
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0027 0.0173 0.0269
Loa Loa (eye worm) hypothetical protein 0.0049 0.0524 0.0524
Brugia malayi p70 ribosomal S6 kinase beta 0.0031 0.0233 0.0233
Giardia lamblia Cathepsin B precursor 0.0139 0.1993 0.5614
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Onchocerca volvulus 0.0048 0.0514 0.16
Echinococcus granulosus tm gpcr rhodopsin 0.0564 0.8891 0.8891
Plasmodium vivax vivapain-3 0.0024 0.0118 0.0873
Trypanosoma cruzi cysteine proteinase, putative 0.0024 0.0118 0.0183
Loa Loa (eye worm) endoprotease bli-4 0.0632 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0292 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0173 0.0173
Toxoplasma gondii subtilisin SUB11 0.0027 0.0173 0.0345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0292 0.115
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Echinococcus multilocularis nervana 2 0.002 0.0062 0.007
Trypanosoma cruzi subtilisin peptidase 0.0027 0.0173 0.0269
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0139 0.1993 0.1993
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0071 0.011
Brugia malayi cathepsin L-like precursor 0.0027 0.0173 0.0173
Brugia malayi Kringle domain containing protein 0.01 0.1354 0.1354
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0292 0.0453
Echinococcus granulosus cathepsin l1 0.0034 0.0292 0.0292
Schistosoma mansoni hypothetical protein 0.0405 0.6306 0.6306
Echinococcus granulosus calpain A 0.0057 0.0665 0.0665
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0122 0.1716 0.1716
Entamoeba histolytica cysteine protease, putative 0.0024 0.0118 0.4054
Echinococcus granulosus neuroendocrine convertase 2 0.0397 0.6186 0.6186
Schistosoma mansoni hypothetical protein 0.0035 0.031 0.031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0384 0.5974 1
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0122 0.172 0.288
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0292 0.0292
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0292 0.0292
Echinococcus multilocularis hypothetical protein 0.0021 0.0071 0.0079
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0062 0.007
Brugia malayi PAN domain containing protein 0.0048 0.0514 0.0514
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.031 0.031
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0071 0.011
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0071 0.011
Loa Loa (eye worm) hypothetical protein 0.0413 0.6443 0.6443
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0027 0.0173 0.5
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0098 0.0111
Onchocerca volvulus 0.0035 0.031 0.0967
Onchocerca volvulus 0.0034 0.0292 0.0909
Toxoplasma gondii hypothetical protein 0.0048 0.0514 0.1022
Echinococcus granulosus epidermal growth factor receptor 0.0114 0.1587 0.1587
Entamoeba histolytica cysteine protease, putative 0.0024 0.0118 0.4054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0048 0.0514 0.0514
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.031 0.031
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0384 0.5974 0.6719
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0292 0.0488
Plasmodium falciparum subtilisin-like protease 1 0.0027 0.0173 0.1282
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0149 0.2159 0.3614
Schistosoma mansoni site-1 peptidase (S08 family) 0.0027 0.0173 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.0118 0.0248
Trypanosoma brucei rac serine-threonine kinase, putative 0.0033 0.0265 0.1013
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0027 0.0173 0.5
Mycobacterium ulcerans hypothetical protein 0.0035 0.031 1
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0514 0.1022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0149 0.2159 0.3614
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.172 0.288
Schistosoma mansoni egf-like domain protein 0.0027 0.0174 0.0174
Echinococcus granulosus glycoprotein Antigen 5 0.0035 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0048 0.0514 0.0514
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.172 0.288
Toxoplasma gondii cathepsin CPL 0.0034 0.0292 0.058
Loa Loa (eye worm) cysteine protease 0.0034 0.0292 0.0292
Toxoplasma gondii microneme protein, putative 0.0048 0.0514 0.1022
Echinococcus multilocularis growth factor receptor bound protein 2 0.0122 0.1716 0.193
Toxoplasma gondii calcium binding egf domain-containing protein 0.0027 0.0174 0.0347
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0292 0.2154
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0413 0.6443 0.6443
Trypanosoma brucei subtilisin peptidase 0.0027 0.0173 0.0535
Echinococcus multilocularis neuroendocrine convertase 2 0.0397 0.6186 0.6957
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.172 0.288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0292 0.115
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0122 0.172 0.288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0292 0.115
Onchocerca volvulus 0.0048 0.0514 0.16
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0265 0.0444
Brugia malayi calpain family protein 1 0.0055 0.0625 0.0625
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0292 0.0488
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0665 0.0665
Echinococcus granulosus transmembrane protease serine 3 0.0035 0.031 0.031
Echinococcus granulosus growth factor receptor bound protein 2 0.0122 0.1716 0.1716
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.031 0.031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0292 0.115
Toxoplasma gondii PAN/Apple domain-containing protein 0.0048 0.0514 0.1022
Brugia malayi Trypsin family protein 0.0035 0.031 0.031
Onchocerca volvulus 0.0034 0.0292 0.0909
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0292 0.0488
Giardia lamblia Kinase, AGC PKA 0.002 0.0066 0.0185
Echinococcus granulosus cathepsin b 0.0413 0.6443 0.6443
Onchocerca volvulus 0.0048 0.0514 0.16
Echinococcus multilocularis calpain 7 (C02 family) 0.0021 0.0071 0.0079
Trypanosoma cruzi cysteine proteinase, putative 0.0024 0.0118 0.0183
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0027 0.0173 0.0269
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0027 0.0173 0.0173
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0292 0.0909
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.002 0.0066 0.0485
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0118 0.0118
Loa Loa (eye worm) fibroinase 0.0034 0.0292 0.0292
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0564 0.8891 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0173 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.172 0.288
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0071 0.011
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0265 0.0444
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0514 0.0514
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.0174
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0071 0.011
Echinococcus granulosus nervana 2 0.002 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0173 0.029
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0027 0.0173 0.0535
Loa Loa (eye worm) calpain family protein 1 0.004 0.039 0.039
Echinococcus granulosus cathepsin L 0.0024 0.0118 0.0118
Onchocerca volvulus 0.0048 0.0514 0.16
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0139 0.1993 0.3336
Giardia lamblia Cathepsin B precursor 0.0139 0.1993 0.5614
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0292 0.0488
Loa Loa (eye worm) hypothetical protein 0.0055 0.0625 0.0625
Leishmania major cathepsin L-like protease 0.0034 0.0292 0.115
Brugia malayi neuroendocrine convertase 1 precursor 0.0397 0.6186 0.6186
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0292 0.0488
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0027 0.0173 0.0173
Onchocerca volvulus 0.0048 0.0514 0.16
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0027 0.0173 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0292 0.115
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0632 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0173 0.029
Brugia malayi Trypsin-like protease protein 5 0.0035 0.031 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.172 0.288
Plasmodium vivax vivapain-1 0.0024 0.0118 0.0873
Echinococcus multilocularis Furin 1 0.0149 0.2159 0.2429
Onchocerca volvulus 0.0027 0.0173 0.0541
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0292 0.0328
Brugia malayi celfurPC protein 0.051 0.8014 0.8014
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0292 0.0488
Entamoeba histolytica protein kinase, putative 0.0033 0.0265 0.91
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0384 0.5974 0.5974
Echinococcus granulosus calpain 5 0.0021 0.0071 0.0071
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0514 0.0514
Entamoeba histolytica cysteine protease, putative 0.0024 0.0118 0.4054
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.031 0.031
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0292 0.0292
Leishmania major cathepsin L-like protease 0.0034 0.0292 0.115
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0035 0.031 0.0349
Schistosoma mansoni calpain (C02 family) 0.0021 0.0071 0.0071
Onchocerca volvulus 0.0214 0.3209 1
Brugia malayi Sex muscle abnormal protein 5 0.0122 0.1716 0.1716
Loa Loa (eye worm) hypothetical protein 0.0048 0.0514 0.0514
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0292 0.2154
Onchocerca volvulus 0.0035 0.031 0.0967
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0292 0.0488
Schistosoma mansoni growth factor receptor-bound protein 0.0122 0.1716 0.1716
Loa Loa (eye worm) hypothetical protein 0.0034 0.0289 0.0289
Echinococcus multilocularis calpain family protein 1, d 0.004 0.039 0.0439
Echinococcus granulosus cathepsin L cysteine protease 0.0024 0.0118 0.0118
Leishmania major subtilisin-like serine peptidase 0.0027 0.0173 0.0535
Echinococcus multilocularis nervana 2 0.002 0.0062 0.007
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.031 0.031
Loa Loa (eye worm) calpain family protein 1 0.0055 0.0625 0.0625
Toxoplasma gondii microneme protein MIC4 0.0048 0.0514 0.1022
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0071 0.011
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0292 0.0292
Echinococcus multilocularis transmembrane protease serine 3 0.0035 0.031 0.0349
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.031 0.031
Onchocerca volvulus 0.0034 0.0289 0.0901
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0214 0.3209 0.3209
Trypanosoma cruzi cruzipain precursor, putative 0.0034 0.0292 0.0453
Brugia malayi Cathepsin L-like precursor 0.0027 0.0173 0.0173
Brugia malayi PAN domain containing protein 0.0048 0.0514 0.0514
Brugia malayi Trypsin family protein 0.0214 0.3209 0.3209
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0057 0.0665 0.0665
Toxoplasma gondii subtilisin SUB10 0.0027 0.0173 0.0345
Entamoeba histolytica cysteine protease, putative 0.0024 0.0118 0.4054
Brugia malayi Furin-like cysteine rich region family protein 0.0114 0.1587 0.1587
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0413 0.6443 0.6443
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0413 0.6443 0.6443
Loa Loa (eye worm) hypothetical protein 0.01 0.1354 0.1354
Trichomonas vaginalis hypothetical protein 0.0122 0.172 0.288
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.031 0.031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Onchocerca volvulus 0.0034 0.0292 0.0909
Echinococcus granulosus cathepsin b 0.0413 0.6443 0.6443
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.031 0.031
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0292 0.0453
Brugia malayi Fibulin-1 precursor 0.0027 0.0174 0.0174
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0292 0.0453
Echinococcus granulosus serine threonine protein kinase nrc 0.002 0.0066 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Leishmania major cathepsin L-like protease 0.0034 0.0292 0.115
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0292 0.0328
Loa Loa (eye worm) hypothetical protein 0.0632 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0149 0.2159 0.3614
Onchocerca volvulus 0.0027 0.0173 0.054
Plasmodium vivax subtilisin-like serine protease, putative 0.0027 0.0173 0.1282
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0098 0.3375
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0122 0.172 0.288
Schistosoma mansoni hypothetical protein 0.01 0.1354 0.1354
Toxoplasma gondii microneme protein MIC17A 0.0048 0.0514 0.1022
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0027 0.0173 0.5
Toxoplasma gondii subtilisin SUB1 0.0027 0.0173 0.0345
Brugia malayi Cathepsin L-like precursor 0.0034 0.0292 0.0292
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0265 0.0444
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0098 0.3375
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0292 0.0488
Brugia malayi cathepsin B-like cysteine proteinase 0.0413 0.6443 0.6443
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0665 0.0665
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0292 0.0488
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0149 0.2159 0.2159
Echinococcus granulosus nervana 2 0.002 0.0062 0.0062
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0413 0.6443 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0024 0.0118 0.4054
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.0174
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0027 0.0174 0.0174
Brugia malayi Calcium binding EGF domain containing protein 0.0027 0.0174 0.0174
Leishmania major cathepsin L-like protease 0.0034 0.0292 0.115
Leishmania major cathepsin L-like protease 0.0034 0.0292 0.115
Toxoplasma gondii subtilisin SUB6 0.0027 0.0173 0.0345
Brugia malayi Cathepsin L-like cysteine proteinase 0.0027 0.0173 0.0173
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0062 0.007
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.002 0.0066 0.0485
Brugia malayi Cathepsin L-like precursor 0.0034 0.0292 0.0292
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0062 0.0062
Onchocerca volvulus 0.0034 0.0292 0.0909
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.002 0.0066 0.0074
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0035 0.031 0.031
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0027 0.0173 0.0269
Loa Loa (eye worm) hypothetical protein 0.0027 0.0173 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0173 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.172 0.288
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0062 0.0062
Toxoplasma gondii microneme protein MIC17B 0.0048 0.0514 0.1022
Toxoplasma gondii kringle domain-containing protein 0.01 0.1354 0.2695
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0055 0.0625 0.0625
Echinococcus multilocularis epidermal growth factor receptor 0.0114 0.1587 0.1785
Loa Loa (eye worm) proprotein convertase 2 0.0149 0.2159 0.2159
Toxoplasma gondii AGC kinase 0.0031 0.0233 0.0463
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0173 0.0173
Toxoplasma gondii PAN domain-containing protein 0.0326 0.5023 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0098 0.0153
Trypanosoma cruzi Protein kinase B 0.0022 0.0098 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0292 0.0488
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0118 0.4054
Brugia malayi PAN domain containing protein 0.0048 0.0514 0.0514
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0292 0.0292
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0027 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0048 0.0514 0.0514
Toxoplasma gondii subtilisin SUB7 0.0027 0.0173 0.0345
Echinococcus multilocularis cathepsin b 0.0413 0.6443 0.7247
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0173 0.5946
Toxoplasma gondii subtilisin SUB2 0.0027 0.0173 0.0345
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0292 0.0328
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0027 0.0173 0.5
Plasmodium vivax vivapain-2 0.0034 0.0292 0.2154
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Echinococcus multilocularis calpain 0.0021 0.0071 0.0079
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.0174
Loa Loa (eye worm) ctsf protein 0.0034 0.0292 0.0292
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0035 0.031 0.031
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0514 0.0514
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0292 0.115
Echinococcus multilocularis membrane bound transcription factor site 1 0.0027 0.0173 0.0195
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0214 0.3209 0.3209
Toxoplasma gondii subtilisin SUB5 0.0027 0.0173 0.0345
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0292 0.115
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0292 0.0488
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0413 0.6443 0.6443
Onchocerca volvulus 0.0035 0.031 0.0967
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0057 0.0665 0.0748
Trypanosoma cruzi rac serine-threonine kinase, putative 0.002 0.0066 0.0102
Onchocerca volvulus 0.0048 0.0514 0.16
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.031 0.031
Entamoeba histolytica cysteine protease, putative 0.0024 0.0118 0.4054
Leishmania major cathepsin L-like protease 0.0034 0.0292 0.115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0292 0.0488
Brugia malayi proprotein convertase 2 0.0397 0.6186 0.6186
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.172 0.288
Entamoeba histolytica cysteine protease, putative 0.0024 0.0118 0.4054
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0024 0.0118 0.0183
Onchocerca volvulus 0.0048 0.0514 0.16
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.172 0.288
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0292 0.0488
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0071 0.0071
Brugia malayi PAN domain containing protein 0.0048 0.0514 0.0514
Entamoeba histolytica cysteine protease, putative 0.0034 0.0292 1
Giardia lamblia Furin precursor putative serine protease 0.0122 0.172 0.4847
Mycobacterium leprae Possible secreted protease 0.0027 0.0173 0.5
Schistosoma mansoni hypothetical protein 0.0035 0.031 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0292 0.0488
Onchocerca volvulus 0.0048 0.0514 0.16
Echinococcus multilocularis cathepsin L 0.0024 0.0118 0.0133
Onchocerca volvulus 0.0048 0.0514 0.16
Entamoeba histolytica cysteine protease, putative 0.0024 0.0118 0.4054
Echinococcus granulosus Furin 1 0.0149 0.2159 0.2159
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0265 0.0444
Trypanosoma brucei cysteine peptidase C (CPC) 0.0139 0.1993 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0514 0.0514
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0292 0.0488
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Entamoeba histolytica cysteine protease, putative 0.0024 0.0118 0.4054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Plasmodium falciparum subtilisin-like protease 2 0.0027 0.0173 0.1282
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0292 0.0909
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0292 0.0453
Plasmodium vivax vivapain-2 0.0034 0.0292 0.2154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0292 0.115
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.172 0.288
Trypanosoma cruzi cysteine protease, putative 0.0024 0.0118 0.0183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0292 0.0488
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0149 0.2159 0.3614
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0265 0.0444
Entamoeba histolytica cysteine protease, putative 0.0024 0.0118 0.4054
Schistosoma mansoni hypothetical protein 0.0122 0.172 0.172
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0514 0.1022
Toxoplasma gondii cathepsin B 0.0139 0.1993 0.3967
Giardia lamblia High cysteine membrane protein Group 2 0.0235 0.3549 1
Leishmania major cathepsin L-like protease 0.0034 0.0292 0.115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0118 0.0198
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0514 0.1022
Toxoplasma gondii PAN domain-containing protein 0.0048 0.0514 0.1022
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0292 0.0909
Echinococcus multilocularis tissue type plasminogen activator 0.01 0.1354 0.1523
Loa Loa (eye worm) hypothetical protein 0.0214 0.3209 0.3209
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0027 0.0173 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0292 0.0488
Entamoeba histolytica cysteine protease, putative 0.0024 0.0118 0.4054
Onchocerca volvulus 0.0035 0.031 0.0967
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0292 0.0488
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0514 0.0514
Entamoeba histolytica protein kinase, putative 0.0031 0.0233 0.7977
Echinococcus multilocularis Mastin 0.0035 0.031 0.0349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0173 0.029
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0118 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0173 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0292 0.0488
Loa Loa (eye worm) subtilase 0.0027 0.0173 0.0173
Plasmodium falciparum cysteine proteinase falcipain 1 0.0024 0.0118 0.0873
Echinococcus granulosus calpain A 0.0021 0.0071 0.0071
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0027 0.0173 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0292 0.115
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.031 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0173 0.029
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0031 0.0233 0.0233
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0292 0.0488
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0292 0.2154
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Toxoplasma gondii PAN domain-containing protein 0.0326 0.5023 1
Brugia malayi PAN domain containing protein 0.0048 0.0514 0.0514
Brugia malayi PAN domain containing protein 0.0048 0.0514 0.0514
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0118 0.0118
Brugia malayi Trypsin family protein 0.0035 0.031 0.031
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0035 0.031 0.031
Toxoplasma gondii subtilisin SUB9 0.0027 0.0173 0.0345
Loa Loa (eye worm) hypothetical protein 0.0034 0.0292 0.0292
Toxoplasma gondii microneme protein MIC17C 0.0048 0.0514 0.1022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.0174
Onchocerca volvulus 0.01 0.1354 0.4218
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0035 0.031 0.0349
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0027 0.0174 0.0174
Echinococcus granulosus Tolloid protein 1 0.0027 0.0174 0.0174
Loa Loa (eye worm) PAN domain-containing protein 0.0048 0.0514 0.0514
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.031 0.031
Brugia malayi PAN domain containing protein 0.0048 0.0514 0.0514
Echinococcus granulosus cysteine protease 0.0024 0.0118 0.0118
Brugia malayi Cathepsin L-like precursor 0.0034 0.0292 0.0292
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0384 0.5974 1
Echinococcus granulosus laminin 0.0027 0.0174 0.0174
Echinococcus multilocularis laminin 0.0027 0.0174 0.0196
Echinococcus multilocularis fibrillin 1 0.0027 0.0174 0.0196
Toxoplasma gondii calcium binding egf domain-containing protein 0.0027 0.0174 0.0347
Brugia malayi Protein kinase domain containing protein 0.0033 0.0265 0.0265
Plasmodium vivax subtilisin-like protease 1 0.0027 0.0173 0.1282
Loa Loa (eye worm) TK/ROR protein kinase 0.01 0.1354 0.1354
Loa Loa (eye worm) hypothetical protein 0.0048 0.0514 0.0514
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0292 0.0488
Echinococcus multilocularis calpain 5 0.0021 0.0071 0.0079
Toxoplasma gondii subtilisin SUB12 0.0075 0.0952 0.1896
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0292 0.0292
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0071 0.011
Onchocerca volvulus 0.0048 0.0514 0.16
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0292 0.0328
Loa Loa (eye worm) trypsin family protein 0.0035 0.031 0.031
Toxoplasma gondii hypothetical protein 0.0048 0.0514 0.1022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0292 0.0488
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0149 0.2159 0.3614
Brugia malayi PAN domain containing protein 0.0048 0.0514 0.0514
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0027 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0035 0.031 0.031
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0048 0.0514 0.1022
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.031 0.031
Schistosoma mansoni tyrosine kinase 0.0114 0.1587 0.1587
Toxoplasma gondii subtilisin SUB4 0.0027 0.0173 0.0345
Onchocerca volvulus 0.0179 0.2633 0.8206
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0292 0.0488
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0118 0.4054
Loa Loa (eye worm) hypothetical protein 0.0048 0.0514 0.0514
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0292 0.115
Loa Loa (eye worm) calpain 0.0021 0.0071 0.0071
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0071 0.011
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0098 0.0098
Toxoplasma gondii subtilisin SUB8 0.0027 0.0173 0.0345
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0265 0.0265
Echinococcus multilocularis enteropeptidase 0.0035 0.031 0.0349
Echinococcus multilocularis calpain A 0.0057 0.0665 0.0748
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0292 0.115
Schistosoma mansoni growth factor receptor-bound protein 0.0122 0.1716 0.1716
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0024 0.0118 0.0118
Onchocerca volvulus 0.0048 0.0513 0.1598
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0292 0.0488
Trypanosoma cruzi hypothetical protein, conserved 0.01 0.1354 0.2101
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.031 0.031
Echinococcus multilocularis cysteine protease 0.0034 0.0292 0.0328
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0292 0.0488
Brugia malayi Cathepsin L-like precursor 0.0027 0.0173 0.0173
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0027 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0035 0.031 0.031
Schistosoma mansoni cercarial elastase (S01 family) 0.0035 0.031 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0118 0.0198
Onchocerca volvulus Arrow homolog 0.0027 0.0174 0.0543
Echinococcus granulosus dnaJ subfamily B 0.0405 0.6306 0.6306
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.002 0.0066 0.0066
Echinococcus granulosus enteropeptidase 0.0035 0.031 0.031
Plasmodium vivax unspecified product 0.0024 0.0118 0.0873
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0024 0.0118 0.0248
Onchocerca volvulus 0.0034 0.0292 0.0909
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0098 0.0098
Echinococcus granulosus membrane bound transcription factor site 1 0.0027 0.0173 0.0173
Brugia malayi hypothetical protein 0.0035 0.031 0.031
Echinococcus granulosus Mastin 0.0035 0.031 0.031
Entamoeba histolytica protein kinase, putative 0.0033 0.0265 0.91
Plasmodium falciparum subtilisin-like protease 3 0.0027 0.0173 0.1282
Echinococcus multilocularis Tolloid protein 1 0.0027 0.0174 0.0196
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0118 0.4054
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.6306 0.7092
Echinococcus granulosus calpain 0.0021 0.0071 0.0071
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0035 0.031 0.031
Leishmania major hypothetical protein, conserved 0.01 0.1354 0.6675
Entamoeba histolytica cysteine protease, putative 0.0024 0.0118 0.4054
Loa Loa (eye worm) hypothetical protein 0.0035 0.031 0.031
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0071 0.011
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0027 0.0173 0.0195
Schistosoma mansoni site-1 peptidase (S08 family) 0.0027 0.0173 0.0173
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Onchocerca volvulus 0.0034 0.0292 0.0909
Plasmodium falciparum cysteine repeat modular protein 1 0.01 0.1354 1
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0265 0.0444
Echinococcus multilocularis 0.051 0.8014 0.9014
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0027 0.0174 0.0174
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0292 0.0292
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0035 0.031 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.172 0.288
Plasmodium vivax calpain, putative 0.0021 0.0071 0.0521
Brugia malayi Cathepsin L-like precursor 0.0034 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0035 0.031 0.031
Brugia malayi Trypsin family protein 0.0035 0.031 0.031
Entamoeba histolytica protein kinase 2, putative 0.002 0.0066 0.2252
Plasmodium vivax subtilisin-like protease 2, putative 0.0027 0.0173 0.1282
Brugia malayi PAN domain containing protein 0.0048 0.0514 0.0514
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0071 0.0071
Loa Loa (eye worm) cathepsin B 0.0139 0.1993 0.1993
Loa Loa (eye worm) hypothetical protein 0.004 0.039 0.039
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0139 0.1993 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0139 0.1993 0.3093
Loa Loa (eye worm) hypothetical protein 0.0035 0.031 0.031
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0027 0.0173 0.5
Brugia malayi calpain family protein 1 0.0055 0.0625 0.0625
Plasmodium vivax cysteine repeat modular protein 1, putative 0.01 0.1354 1
Onchocerca volvulus 0.0048 0.0514 0.16
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0292 1
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0071 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0292 0.115
Onchocerca volvulus 0.0034 0.0292 0.0909
Loa Loa (eye worm) hypothetical protein 0.0214 0.3209 0.3209
Brugia malayi Cathepsin L-like precursor 0.0034 0.0292 0.0292
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0149 0.2159 0.3614
Brugia malayi Cathepsin L-like precursor 0.0034 0.0292 0.0292
Giardia lamblia Cathepsin B precursor 0.0139 0.1993 0.5614
Echinococcus granulosus furin 0.0632 1 1
Onchocerca volvulus 0.0035 0.031 0.0967
Schistosoma mansoni furin-1 (S08 family) 0.0275 0.42 0.42
Leishmania major cathepsin L-like protease 0.0034 0.0292 0.115
Trypanosoma cruzi cysteine peptidase, putative 0.0024 0.0118 0.0183
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0071 0.0071
Entamoeba histolytica cysteine protease, putative 0.0024 0.0118 0.4054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Brugia malayi Protein kinase domain containing protein 0.01 0.1354 0.1354
Loa Loa (eye worm) TK/EGFR protein kinase 0.0114 0.1587 0.1587
Echinococcus granulosus cathepsin l1 0.0027 0.0173 0.0173
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0265 0.0444
Echinococcus multilocularis cysteine protease 0.0034 0.0292 0.0328
Loa Loa (eye worm) hypothetical protein 0.0027 0.0173 0.0173
Echinococcus granulosus tissue type plasminogen activator 0.01 0.1354 0.1354
Echinococcus multilocularis glycoprotein Antigen 5 0.0035 0.031 0.0349
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0027 0.0173 0.0269
Brugia malayi Papain family cysteine protease containing protein 0.0024 0.0118 0.0118
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0118 0.4054
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Entamoeba histolytica cysteine proteinase 2 0.0024 0.0118 0.4054
Loa Loa (eye worm) hypothetical protein 0.0027 0.0173 0.0173
Entamoeba histolytica cysteine protease, putative 0.0024 0.0118 0.4054
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0071 0.011
Brugia malayi calpain 7 0.0021 0.0071 0.0071
Brugia malayi PAN domain containing protein 0.0048 0.0514 0.0514
Brugia malayi Subtilase family protein 0.0027 0.0173 0.0173
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0027 0.0173 0.029
Echinococcus multilocularis cathepsin b 0.0413 0.6443 0.7247
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.172 0.288

Activities

Activity type Activity value Assay description Source Reference
Agonist activity (functional) Agonist activity was measured for histamine H2-receptor in guinea pig atrium; -ve; <0.1% of histamine (781 microM/L) ChEMBL. 6128418
Agonist activity (functional) In vivo agonist activity against histamine H2-receptor in lumen-perfused stomach of atropinized (1 mg/kg) anesthetized rat gastric secretion at 187 microg/kg; -ve ChEMBL. 6128418
Agonist activity (functional) = 2.3 In vitro agonist activity against histamine H1-receptor in guinea pig ileum in the presence of atropine (0.5 uM) relative to histamine ChEMBL. 6128418
Agonist activity (functional) 0 Agonist activity was measured for histamine H2-receptor in guinea pig atrium; -ve; <0.1% of histamine (781 microM/L) ChEMBL. 6128418
Agonist activity (functional) 0 In vivo agonist activity against histamine H2-receptor in lumen-perfused stomach of atropinized (1 mg/kg) anesthetized rat gastric secretion at 187 microg/kg; -ve ChEMBL. 6128418
Agonist activity (functional) = 2.3 In vitro agonist activity against histamine H1-receptor in guinea pig ileum in the presence of atropine (0.5 uM) relative to histamine ChEMBL. 6128418
Antagonist activity (functional) In vivo antagonist activity against histamine H2-receptor in lumen-perfused stomach of atropinized (1 mg/kg) anesthetized rat gastric secretion at 128 microg/kg; -ve ChEMBL. 6128418
Antagonist activity (functional) < 3.3 Antagonist activity was measured for histamine H2-receptor in guinea pig atrium; -ve ChEMBL. 6128418
Antagonist activity (functional) 0 In vivo antagonist activity against histamine H2-receptor in lumen-perfused stomach of atropinized (1 mg/kg) anesthetized rat gastric secretion at 128 microg/kg; -ve ChEMBL. 6128418
Antagonist activity (functional) < 3.3 Antagonist activity was measured for histamine H2-receptor in guinea pig atrium; -ve ChEMBL. 6128418

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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