Detailed information for compound 179494

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 557.595 | Formula: C27H35N5O8
  • H donors: 6 H acceptors: 8 LogP: 0.35 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 3
  • SMILES: CN(CC(=O)Nc1cc(N(C)C)c2c(c1O)C(=O)C1=C(O)[C@]3([C@@H](CC1C2)[C@H](N(C)C)C(=O)C(=C3O)C(=O)N)O)C
  • InChi: 1S/C27H35N5O8/c1-30(2)10-16(33)29-14-9-15(31(3)4)12-7-11-8-13-20(32(5)6)23(36)19(26(28)39)25(38)27(13,40)24(37)17(11)22(35)18(12)21(14)34/h9,11,13,20,34,37-38,40H,7-8,10H2,1-6H3,(H2,28,39)(H,29,33)/t11?,13-,20-,27-/m0/s1
  • InChiKey: JTNZRCFNDUJNID-JGBGPNONSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0218 0.0346
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0461 0.0248
Loa Loa (eye worm) hypothetical protein 0.005 0.0461 0.0606
Schistosoma mansoni tyrosine kinase 0.0023 0.0069 0.0031
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0192 0.257 0.941
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.01 0.017
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0218 0.0287
Leishmania major hypothetical protein, conserved 0.0109 0.1337 0.7108
Echinococcus granulosus nmda type glutamate receptor 0.0189 0.2521 0.9229
Leishmania major developmentally regulated phosphoprotein-like protein 0.0144 0.1852 1
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0072 0.0786 0.098
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0299 0.0393
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.003 0.0172 0.0439
Mycobacterium ulcerans lipase LipD 0.0109 0.1337 0.1514
Echinococcus multilocularis NMDA receptor 0.003 0.0172 0.0439
Brugia malayi metabotropic glutamate receptor type 2 0.0055 0.0544 0.063
Schistosoma mansoni hypothetical protein 0.0309 0.4292 0.5617
Schistosoma mansoni protein kinase 0.0023 0.0069 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.066 0.0599
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.005 0.0471 0.1188
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0706 0.244
Brugia malayi Metabotropic glutamate receptor precursor. 0.0097 0.1162 0.145
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0072 0.0786 0.402
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.1337 0.1144
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1816 0.6593
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0072 0.0786 0.3814
Schistosoma mansoni pyruvate dehydrogenase 0.0136 0.1734 0.2234
Loa Loa (eye worm) glutamate receptor 0.0032 0.0204 0.0268
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0141 0.1809 0.2333
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0218 0.0518
Schistosoma mansoni glutamate receptor kainate 0.0081 0.0925 0.1163
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0706 0.244
Trypanosoma brucei developmentally regulated phosphoprotein 0.0144 0.1852 1
Plasmodium vivax peptide deformylase, putative 0.023 0.3126 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0166 0.0218
Schistosoma mansoni P2X receptor subunit 0.0066 0.0706 0.0874
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0023 0.0069 0.0057
Loa Loa (eye worm) hypothetical protein 0.0109 0.1337 0.1758
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0845 0.296
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.028 0.0845
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.066 0.0599
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0046 0.006
Brugia malayi MH2 domain containing protein 0.0255 0.3493 0.4543
Echinococcus granulosus glutamate NMDA receptor subunit 0.0192 0.257 0.941
Loa Loa (eye worm) glutamate receptor 2 0.0081 0.0925 0.1216
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.066 0.1815
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.1337 0.1514
Echinococcus granulosus glutamate receptor 2 0.0074 0.0823 0.2875
Brugia malayi Bromodomain containing protein 0.004 0.0316 0.0328
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1337 0.1616
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.2727 1
Brugia malayi mbt repeat family protein 0.005 0.0461 0.0519
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1816 0.2343
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0218 0.0197
Echinococcus granulosus prolyl endopeptidase 0.0141 0.1809 0.6565
Schistosoma mansoni pyruvate kinase 0.0033 0.0218 0.0228
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0129 0.0784
Echinococcus multilocularis pyruvate kinase 0.0033 0.0218 0.0613
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0845 0.2429
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.007 0.0009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.1337 0.1758
Trichomonas vaginalis set domain proteins, putative 0.0244 0.3339 0.4294
Trypanosoma cruzi prefoldin subunit, putative 0.0035 0.0241 0.0963
Echinococcus multilocularis nmda type glutamate receptor 0.0189 0.2521 0.9229
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.1816 0.2318
Mycobacterium tuberculosis Conserved protein 0.0109 0.1337 0.1144
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.066 0.0813
Plasmodium falciparum peptide deformylase 0.023 0.3126 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0408 0.0537
Trypanosoma brucei prolyl oligopeptidase, putative 0.0064 0.0678 0.3189
Loa Loa (eye worm) hypothetical protein 0.0051 0.0487 0.064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0192 0.0194
Trichomonas vaginalis glutaminase, putative 0.0533 0.7605 1
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0218 0.0455
Loa Loa (eye worm) prolyl oligopeptidase 0.0186 0.2484 0.3267
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0706 0.244
Brugia malayi Glutamate receptor 2 precursor 0.0081 0.0925 0.1135
Echinococcus granulosus cpg binding protein 0.0033 0.022 0.0619
Echinococcus granulosus nmda type glutamate receptor 0.0182 0.2419 0.8846
Schistosoma mansoni pyruvate kinase 0.0033 0.0218 0.0228
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0299 0.0616
Schistosoma mansoni tyrosine kinase 0.0023 0.0069 0.0031
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0299 0.0616
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0218 0.0518
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0129 0.011
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0218 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0241 0.015
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0562 0.0683
Schistosoma mansoni glutamate receptor NMDA 0.0263 0.3615 0.4721
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.0092
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0461 0.1152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1816 0.6593
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.013 0.0053
Onchocerca volvulus 0.0031 0.0192 0.0376
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0091
Trypanosoma cruzi Peptide deformylase 2, putative 0.0088 0.1025 0.5361
Echinococcus multilocularis prefoldin subunit 6 0.0035 0.0241 0.0699
Brugia malayi beta-lactamase family protein 0.0109 0.1337 0.1682
Mycobacterium tuberculosis Conserved protein 0.0109 0.1337 0.1144
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.013 0.0053
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.023 0.3126 1
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0072 0.0786 0.402
Echinococcus multilocularis glutamate receptor 2 0.0104 0.1265 0.453
Plasmodium vivax prefoldin subunit 6, putative 0.0035 0.0241 0.0423
Loa Loa (eye worm) hypothetical protein 0.0109 0.1337 0.1758
Loa Loa (eye worm) hypothetical protein 0.0076 0.0845 0.1111
Onchocerca volvulus 0.005 0.0461 0.1197
Loa Loa (eye worm) hypothetical protein 0.0035 0.0247 0.0325
Brugia malayi Pre-SET motif family protein 0.0031 0.0192 0.0163
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0461 0.1521
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.1337 0.1144
Loa Loa (eye worm) hypothetical protein 0.004 0.0318 0.0418
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0845 0.2429
Schistosoma mansoni glutamate receptor AMPA 0.0081 0.0925 0.1163
Loa Loa (eye worm) glutaminase 2 0.0533 0.7605 1
Echinococcus multilocularis tyrosine kinase 0.0023 0.0069 0.0057
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0218 0.0346
Mycobacterium leprae Probable lipase LipE 0.0109 0.1337 0.4061
Leishmania major pyruvate kinase 0.0033 0.0218 0.0834
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0129 0.005
Plasmodium vivax hypothetical protein, conserved 0.0109 0.1337 0.4061
Loa Loa (eye worm) hypothetical protein 0.0116 0.1441 0.1895
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0116 0.1441 0.5188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.0317
Schistosoma mansoni glutamate receptor NMDA 0.0192 0.257 0.3339
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0299 0.0305
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0461 0.0248
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.2902 0.3816
Loa Loa (eye worm) hypothetical protein 0.0109 0.1337 0.1758
Loa Loa (eye worm) hypothetical protein 0.0027 0.0129 0.0169
Schistosoma mansoni pyruvate dehydrogenase 0.0136 0.1734 0.2234
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.013 0.0053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.1337 0.1708
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0706 0.244
Schistosoma mansoni ap endonuclease 0.0039 0.0299 0.0335
Echinococcus multilocularis pyruvate kinase 0.0026 0.0115 0.0227
Echinococcus multilocularis p2X purinoceptor 4 0.0066 0.0706 0.244
Mycobacterium ulcerans peptide deformylase 0.023 0.3126 0.3936
Brugia malayi Cytochrome P450 family protein 0.0028 0.0145 0.01
Schistosoma mansoni P2X receptor subunit 0.0066 0.0706 0.0874
Schistosoma mansoni cpg binding protein 0.0033 0.022 0.023
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0192 0.0261
Loa Loa (eye worm) RGC/RGC protein kinase 0.0023 0.0069 0.0091
Echinococcus granulosus receptor type guanylyl cyclase 0.0023 0.0069 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1816 0.6593
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0562 0.19
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0088 0.1025 0.5361
Giardia lamblia Hypothetical protein 0.0035 0.0241 0.6592
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.067 0.2302
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.023 0.3126 0.2972
Leishmania major prefoldin subunit, putative 0.0035 0.0241 0.0963
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0461 0.1521
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0104 0.1265 0.453
Trypanosoma brucei prefoldin subunit, putative 0.0035 0.0241 0.0651
Plasmodium falciparum pyruvate kinase 0.0033 0.0218 0.0346
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.01 0.0072
Brugia malayi PHD-finger family protein 0.0028 0.0136 0.0089
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0064 0.0678 0.0471
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0299 0.1288
Entamoeba histolytica hypothetical protein 0.0074 0.0827 1
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1337 0.1616
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0036 0.0265 0.0349
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0064 0.0678 0.0623
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1337 0.1616
Mycobacterium ulcerans beta-lactamase 0.0109 0.1337 0.1514
Schistosoma mansoni metabotropic glutamate receptor 0.0084 0.0966 0.1218
Leishmania major hypothetical protein, conserved 0.0027 0.013 0.0339
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.1337 0.1144
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0299 0.0083
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0091
Loa Loa (eye worm) hypothetical protein 0.0109 0.1337 0.1758
Brugia malayi beta-lactamase 0.0109 0.1337 0.1682
Schistosoma mansoni P2X receptor subunit 0.0066 0.0706 0.0874
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.1337 0.7108
Onchocerca volvulus 0.0244 0.3339 1
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0129 0.0784
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.003 0.0172 0.0439
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0827 0.2892
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0845 0.1058
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0218 0.0834
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0064 0.0678 0.3416
Loa Loa (eye worm) MH2 domain-containing protein 0.0255 0.3493 0.4593
Echinococcus granulosus metabotropic glutamate receptor 5 0.0116 0.1441 0.5188
Brugia malayi hypothetical protein 0.0044 0.0386 0.0421
Trypanosoma brucei Peptide deformylase 2 0.0088 0.1025 0.5201
Mycobacterium leprae conserved hypothetical protein 0.0109 0.1337 0.4061
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0058 0.0589 0.158
Brugia malayi glutaminase DH11.1 0.0533 0.7605 1
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0064 0.0678 0.3416
Echinococcus multilocularis glutamate receptor subunit protein glur 0.003 0.0172 0.0439
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0454 0.054
Treponema pallidum polypeptide deformylase (def) 0.023 0.3126 1
Echinococcus multilocularis prolyl endopeptidase 0.0141 0.1809 0.6565
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.1337 0.1682
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.1337 0.1144
Echinococcus multilocularis cpg binding protein 0.0033 0.022 0.0619
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0104 0.1265 0.453
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0827 0.2892
Toxoplasma gondii hypothetical protein 0.023 0.3126 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0454 0.0597
Echinococcus granulosus glutamate receptor NMDA 0.0159 0.2079 0.7573
Trypanosoma brucei prolyl endopeptidase 0.0141 0.1809 0.975
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0129 0.0784
Onchocerca volvulus 0.003 0.0166 0.0294
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0218 0.0119
Echinococcus granulosus p2X purinoceptor 4 0.0066 0.0706 0.244
Brugia malayi Pre-SET motif family protein 0.0215 0.2902 0.3759
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.1337 0.1708
Loa Loa (eye worm) hypothetical protein 0.0044 0.0386 0.0508
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0218 0.0455
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0672 0.0828
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.066 0.2268
Loa Loa (eye worm) hypothetical protein 0.0027 0.013 0.0171
Schistosoma mansoni hypothetical protein 0.0035 0.0241 0.0259
Brugia malayi CXXC zinc finger family protein 0.003 0.0166 0.0128
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0609 0.1645
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0845 0.1933
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0072 0.0786 0.2233
Brugia malayi hypothetical protein 0.0074 0.0827 0.1006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1816 0.2343
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0186 0.2484 0.9092
Schistosoma mansoni cpg binding protein 0.0033 0.022 0.023
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.066 0.0599
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.066 0.0813
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0218 0.0455
Loa Loa (eye worm) hypothetical protein 0.0141 0.1809 0.2379
Entamoeba histolytica prefoldin subunit 6, putative 0.0035 0.0241 0.2265
Trypanosoma brucei oligopeptidase b 0.0064 0.0678 0.3189
Entamoeba histolytica hypothetical protein 0.0074 0.0827 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0218 0.0119
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0845 0.2158
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0461 0.1521
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.007 0.0092
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0299 0.0228
Echinococcus granulosus glutamate receptor subunit protein glur 0.003 0.0172 0.0439
Loa Loa (eye worm) RGC/RGC protein kinase 0.0023 0.0069 0.0091
Loa Loa (eye worm) hypothetical protein 0.0109 0.1337 0.1758
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0129 0.0784
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.003 0.0172 0.0439
Loa Loa (eye worm) hypothetical protein 0.0042 0.0354 0.0465
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0129 0.0333
Brugia malayi kinase, mitochondrial precursor 0.0144 0.1852 0.2366
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0064 0.0678 0.1875
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0562 0.19
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.1337 0.1616
Brugia malayi Glutamate receptor 1 precursor 0.0081 0.0925 0.1135
Trypanosoma cruzi prefoldin subunit, putative 0.0035 0.0241 0.0963
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0129 0.0079
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0471 0.2255
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.1337 0.1144
Loa Loa (eye worm) glutaminase 0.0533 0.7605 1
Brugia malayi Receptor family ligand binding region containing protein 0.0036 0.0265 0.026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.1816 0.2388
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0487 0.064
Brugia malayi prolyl oligopeptidase family protein 0.0186 0.2484 0.3205
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0074 0.0822 0.0999
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0299 0.0228
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.01 0.017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0091
Schistosoma mansoni zinc finger protein 0.0022 0.0054 0.0011
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.028 0.0845
Loa Loa (eye worm) MBCTL1 0.0056 0.0562 0.0739
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.013 0.0053
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0027 0.0129 0.011
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0064 0.0678 0.3416
Brugia malayi Probable ClpP-like protease 0.0076 0.0845 0.103
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0299 0.0916
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0562 0.0654
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0036 0.0265 0.0349
Giardia lamblia Pyruvate kinase 0.0033 0.0218 0.5239
Loa Loa (eye worm) glutamate receptor 1 0.0081 0.0925 0.1216
Brugia malayi beta-lactamase family protein 0.0109 0.1337 0.1682
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0104 0.1265 0.453
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.1337 0.1144
Schistosoma mansoni ATP-binding cassette transporter 0.0081 0.0925 0.1163
Echinococcus multilocularis glutamate receptor 2 0.0074 0.0823 0.2875
Loa Loa (eye worm) transcription factor SMAD2 0.0255 0.3493 0.4593
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0454 0.1495
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0454 0.054
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.1337 0.1144
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0845 0.2429
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0091
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0064 0.0678 0.3189
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0072 0.0786 0.3814
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0218 0.0346
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0299 0.011
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0299 0.3031
Trypanosoma brucei Polypeptide deformylase 1 0.0088 0.1025 0.5201
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0845 0.2429
Loa Loa (eye worm) hypothetical protein 0.0144 0.1852 0.2435
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0471 0.1988
Mycobacterium ulcerans hypothetical protein 0.0109 0.1337 0.1514
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0461 0.0549
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0186 0.2484 0.9092
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0471 0.2255
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0845 0.0849
Loa Loa (eye worm) RGC/RGC protein kinase 0.0023 0.0069 0.0091
Echinococcus granulosus pyruvate kinase 0.0033 0.0218 0.0613
Loa Loa (eye worm) hypothetical protein 0.0033 0.0218 0.0287
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0192 0.0517
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0461 0.1197
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0218 0.0287
Schistosoma mansoni glutaminase 0.0533 0.7605 1
Mycobacterium ulcerans glutaminase 0.0533 0.7605 1
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.003 0.0172 0.0439
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0845 0.2429
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.066 0.2268
Brugia malayi prolyl oligopeptidase family protein 0.0141 0.1809 0.2309
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.1337 0.4798
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0084 0.0966 0.3413
Trypanosoma cruzi prolyl endopeptidase 0.0141 0.1809 0.9758
Brugia malayi hypothetical protein 0.0027 0.013 0.008
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.067 0.2302
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0299 1
Echinococcus multilocularis glutamate receptor 2 0.0081 0.0925 0.3257
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0845 0.2429
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.013 0.0339
Brugia malayi prolyl oligopeptidase family protein 0.0072 0.0786 0.0951
Schistosoma mansoni cpg binding protein 0.003 0.0166 0.0159
Entamoeba histolytica hypothetical protein 0.0074 0.0827 1
Leishmania major pyruvate kinase 0.0033 0.0218 0.0834
Loa Loa (eye worm) beta-lactamase 0.0109 0.1337 0.1758
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0129 0.0079
Mycobacterium tuberculosis Probable peptidase 0.0064 0.0678 0.0471
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0141 0.1809 0.9758
Entamoeba histolytica hypothetical protein 0.0074 0.0827 1
Loa Loa (eye worm) glutamate receptor 0.0097 0.1162 0.1528
Echinococcus multilocularis nmda type glutamate receptor 0.0182 0.2419 0.8846
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0144 0.1852 0.6727
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0023 0.0069 0.0091
Trypanosoma cruzi Peptide deformylase 2, putative 0.0088 0.1025 0.5361
Trichomonas vaginalis esterase, putative 0.0109 0.1337 0.1616
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0129 0.0784
Onchocerca volvulus 0.0109 0.1337 0.3876
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0104 0.1265 0.453
Plasmodium falciparum prefoldin subunit 6, putative 0.0035 0.0241 0.0423
Toxoplasma gondii ABC1 family protein 0.0109 0.1337 0.4061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0091
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0299 0.1288
Onchocerca volvulus 0.0109 0.1337 0.3876
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0845 0.296
Schistosoma mansoni bromodomain containing protein 0.0067 0.0725 0.0898
Trypanosoma cruzi oligopeptidase b 0.0064 0.0678 0.3416
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.066 0.3315
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0129 0.0169
Loa Loa (eye worm) hypothetical protein 0.0109 0.1337 0.1758
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0144 0.1852 0.6727
Chlamydia trachomatis peptide deformylase 0.023 0.3126 1
Schistosoma mansoni hypothetical protein 0.0035 0.0247 0.0267
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0487 0.0554
Brugia malayi mbt repeat family protein 0.005 0.0461 0.0519
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0186 0.2484 0.3226
Toxoplasma gondii prefoldin subunit 6, putative 0.0035 0.0241 0.0423
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0454 0.1495
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0104 0.1265 0.453
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0461 0.0606
Brugia malayi KE2 family protein 0.0035 0.0241 0.0228
Echinococcus multilocularis pyruvate kinase 0.0033 0.0218 0.0613
Toxoplasma gondii exonuclease III APE 0.0039 0.0299 0.0616
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1816 0.6593
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0144 0.1852 1
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0027 0.0129 0.005
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0186 0.2484 0.7387
Echinococcus granulosus prefoldin subunit 6 0.0035 0.0241 0.0699
Schistosoma mansoni glutamate receptor AMPA 0.0081 0.0925 0.1163
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.1337 0.1514
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.066 0.0452
Toxoplasma gondii prolyl endopeptidase 0.0141 0.1809 0.5629
Schistosoma mansoni ap endonuclease 0.0039 0.0299 0.0335
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0072 0.0786 0.2738
Echinococcus multilocularis receptor type guanylyl cyclase 0.0023 0.0069 0.0057
Onchocerca volvulus 0.0109 0.1337 0.3876
Echinococcus granulosus Dipeptidyl peptidase 9 0.0072 0.0786 0.2738
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0088 0.1025 0.5361
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0144 0.1852 0.6727
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.1337 0.7108
Toxoplasma gondii hypothetical protein 0.0027 0.0129 0.005
Echinococcus granulosus atrial natriuretic peptide receptor 0.0023 0.0069 0.0057
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0487 0.0554
Echinococcus multilocularis acylamino acid releasing enzyme 0.0027 0.0129 0.0279
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0461 0.0549
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0299 0.0988
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0299 0.0616
Loa Loa (eye worm) hypothetical protein 0.0056 0.0562 0.0739
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0562 0.19
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.1337 0.1616
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0093 0.1101 0.1396
Loa Loa (eye worm) hypothetical protein 0.0027 0.0129 0.0169
Leishmania major polypeptide deformylase-like protein, putative 0.0088 0.1025 0.5361
Echinococcus granulosus tyrosine kinase 0.0023 0.0069 0.0057
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0166 0.0419
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0091
Schistosoma mansoni hypothetical protein 0.0074 0.0827 0.1034
Leishmania major oligopeptidase b 0.0064 0.0678 0.3416
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.1337 0.4798
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0827 0.1034
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0461 0.1521
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0461 0.0549
Echinococcus granulosus glutamate receptor ionotropic kainate 0.003 0.0172 0.0439
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0247 0.0236
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0104 0.1265 0.453
Echinococcus granulosus metabotropic glutamate receptor 2 0.0084 0.0966 0.3413
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0129 0.0333
Schistosoma mansoni glutamate receptor kainate 0.0081 0.0925 0.1163
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0845 0.0849
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0461 0.1521
Echinococcus multilocularis glutamate receptor NMDA 0.0159 0.2079 0.7573
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0562 0.19
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0461 0.1521
Loa Loa (eye worm) hypothetical protein 0.0073 0.0814 0.107
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0091
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0114 0.1409 0.1218
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0129 0.0784
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0192 0.0194
Schistosoma mansoni P2X receptor subunit 0.0066 0.0706 0.0874
Plasmodium vivax SET domain protein, putative 0.0031 0.0192 0.0261
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0104 0.1265 0.453
Loa Loa (eye worm) hypothetical protein 0.0036 0.0265 0.0349
Schistosoma mansoni pyruvate dehydrogenase 0.0144 0.1852 0.239
Brugia malayi Bromodomain containing protein 0.008 0.0904 0.1108
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.013 0.0006
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0845 0.2158
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0299 0.0916
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0145 0.019
Echinococcus granulosus pyruvate kinase 0.0033 0.0218 0.0613
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0104 0.1265 0.453
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0299 0.1288
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.2727 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0218 0.0834
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0072 0.0786 0.402
Echinococcus granulosus acylamino acid releasing enzyme 0.0027 0.0129 0.0279
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0218 0.0197
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.1337 0.7008
Echinococcus granulosus glutamate receptor 2 0.0104 0.1265 0.453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1816 0.2343
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.023 0.3126 1
Mycobacterium tuberculosis Conserved protein 0.0109 0.1337 0.1144
Onchocerca volvulus Prolyl endopeptidase homolog 0.0141 0.1809 0.5321
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.003 0.0172 0.0439
Schistosoma mansoni hypothetical protein 0.003 0.0172 0.0167
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.013 0.0339
Plasmodium falciparum peptidase, putative 0.0027 0.0129 0.005
Schistosoma mansoni metabotropic glutamate receptor 0.0055 0.0544 0.0659
Schistosoma mansoni glutamate receptor kainate 0.0081 0.0925 0.1163
Trypanosoma cruzi oligopeptidase b 0.0064 0.0678 0.3416
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0141 0.1809 0.2333

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.25 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 90-5 sensitive cell lines ChEMBL. 7932547
MIC (functional) = 0.25 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli J3272 tet-D(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) = 0.25 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 90-4 tet-M(ribosomal protection) cell lines ChEMBL. 7932547
MIC (functional) = 0.25 ug cm**-2 In vitro antibacterial activity was measured on gram positive bacteria S. aureus smith cell lines ChEMBL. 7932547
MIC (functional) = 0.25 ug cm**-2 In vitro antibacterial activity was measured on gram positive bacteria S. aureus UBMS 90-3 sensitive cell lines ChEMBL. 7932547
MIC (functional) = 0.25 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 90-5 sensitive cell lines ChEMBL. 7932547
MIC (functional) = 0.25 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli J3272 tet-D(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) = 0.25 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 90-4 tet-M(ribosomal protection) cell lines ChEMBL. 7932547
MIC (functional) = 0.5 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 88-1 tet-B(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) = 0.5 ug cm**-2 In vitro antibacterial activity was measured on gram positive bacteria S. aureus UBMS 90-1 tet-M(ribosomal protection) cell lines ChEMBL. 7932547
MIC (functional) = 0.5 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli UBMS 88-1 tet-B(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) = 2 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli PRP-1 tet-a(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) = 2 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli J3272 tet-C(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) = 2 ug cm**-2 In vitro antibacterial activity was measured on gram positive bacteria S. aureus UBMS 88-7 tet-k(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) = 2 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli PRP-1 tet-a(efflux resistance) cell lines ChEMBL. 7932547
MIC (functional) = 2 ug cm**-2 In vitro antibacterial activity was measured on gram negative bacteria E. coli J3272 tet-C(efflux resistance) cell lines ChEMBL. 7932547

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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