Detailed information for compound 1802218

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 247.163 | Formula: C8H20Cl2N2O2
  • H donors: 3 H acceptors: 2 LogP: -1.16 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCC(CCCCCC(=O)O)N.Cl.Cl
  • InChi: 1S/C8H18N2O2.2ClH/c9-6-7(10)4-2-1-3-5-8(11)12;;/h7H,1-6,9-10H2,(H,11,12);2*1H
  • InChiKey: RESYYGWSBVSZJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0854 0.7157
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.0854 0.1116
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0028 0.0049
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2281 0.2277
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0111 0.0111
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0111 0.0111
Brugia malayi beta-lactamase family protein 0.0107 0.0854 0.0854
Brugia malayi Protein kinase domain containing protein 0.0248 0.2229 0.2229
Leishmania major GTP-binding protein, putative 0.0042 0.0222 0.0217
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.1193 0.1188
Onchocerca volvulus 0.0031 0.0111 0.0111
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.2281 0.2281
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0222 0.0222
Entamoeba histolytica Ran family GTPase 0.0042 0.0222 0.1825
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0094 0.0725 0.1258
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.0854 1
Entamoeba histolytica hypothetical protein 0.0035 0.0155 0.1266
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0111 0.0193
Giardia lamblia Kinase, STE STE20 0.0038 0.0181 0.1479
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0111 0.0111
Schistosoma mansoni neuroligin 3 (S09 family) 0.0094 0.0725 0.1258
Echinococcus granulosus histone deacetylase 0.0053 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0111
Trichomonas vaginalis STE family protein kinase 0.0038 0.0181 0.0176
Plasmodium falciparum histone deacetylase 2 0.0053 0.0329 0.2756
Echinococcus granulosus protein tyrosine kinase 0.0245 0.2201 0.2201
Brugia malayi Carboxylesterase family protein 0.0094 0.0725 0.0725
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0038 0.0181 0.0181
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0111 0.0111
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0187 0.1535
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0111 0.0111
Echinococcus granulosus histone deacetylase 1 0.0142 0.1193 0.1193
Loa Loa (eye worm) hypothetical protein 0.0365 0.3371 0.3371
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.024 0.024
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2281 0.2277
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0612 0.0612
Echinococcus granulosus histone deacetylase 3 0.0142 0.1193 0.1193
Onchocerca volvulus 0.002 0.0005 0.0005
Brugia malayi Importin beta-1 subunit 0.0057 0.0369 0.0369
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0155 0.027
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0111 0.0193
Echinococcus granulosus histone deacetylase 6 0.0053 0.0329 0.0329
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.0854 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0725 0.0725
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0094 0.0725 0.0913
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0111 0.0193
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0329 0.0324
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2281 0.2277
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0369 0.0364
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0554 0.522 0.9055
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.1044 1 1
Onchocerca volvulus 0.0094 0.0725 0.0725
Brugia malayi hypothetical protein 0.0094 0.0725 0.0725
Echinococcus multilocularis lamin dm0 0.0082 0.0612 0.0612
Toxoplasma gondii histone deacetylase HDAC3 0.0142 0.1193 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0111
Brugia malayi hypothetical protein 0.0035 0.0155 0.0155
Schistosoma mansoni hypothetical protein 0.0031 0.0114 0.0198
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0114 0.0114
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.061 0.5764 0.5764
Loa Loa (eye worm) hypothetical protein 0.0094 0.0725 0.0725
Loa Loa (eye worm) hypothetical protein 0.0107 0.0854 0.0854
Brugia malayi hypothetical protein 0.0365 0.3371 0.3371
Schistosoma mansoni hypothetical protein 0.0031 0.0114 0.0198
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.1432 0.1432
Echinococcus multilocularis histone deacetylase 7 0.0053 0.0329 0.0329
Brugia malayi Histone deacetylase family protein 0.0053 0.0329 0.0329
Brugia malayi Carboxylesterase family protein 0.0094 0.0725 0.0725
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.0854 0.0854
Schistosoma mansoni protein kinase 0.0203 0.179 0.3104
Echinococcus multilocularis histone deacetylase 0.0053 0.0329 0.0329
Echinococcus multilocularis acetylcholinesterase 0.0554 0.522 0.522
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0329 0.0324
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0854 0.0849
Entamoeba histolytica hypothetical protein 0.0035 0.0155 0.1266
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0111 0.0111
Brugia malayi Lipase family protein 0.002 0.0005 0.0005
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0111 0.0193
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0111 0.0111
Schistosoma mansoni histone deacetylase 0.0142 0.1193 0.2069
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0222 0.0222
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0369 0.0369
Toxoplasma gondii histone deacetylase HDAC4 0.0053 0.0329 0.2725
Schistosoma mansoni histone deacetylase 4 5 0.0053 0.0329 0.057
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.1193 0.1188
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0038 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0145 0.1224 0.1224
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0187 0.5
Loa Loa (eye worm) hypothetical protein 0.0094 0.0725 0.0725
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0612 0.0612
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0094 0.0725 0.0913
Plasmodium vivax histone deacetylase, putative 0.0053 0.0329 0.2756
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0369 0.3064
Loa Loa (eye worm) lipase 0.1044 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0111 0.0111
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0203 0.179 0.179
Onchocerca volvulus 0.0107 0.0854 0.0854
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0187 0.1535
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.0854 0.0854
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0035 0.0155 0.027
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0222 0.0217
Trichomonas vaginalis lipase containing protein, putative 0.1044 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.0854 0.0854
Onchocerca volvulus 0.0082 0.0612 0.0612
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1519 0.1514
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.1193 0.1188
Trypanosoma brucei histone deacetylase 2 0.0053 0.0329 0.0324
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0114 0.0114
Brugia malayi steroid hormone receptor 0.0031 0.0111 0.0111
Echinococcus multilocularis neuroligin 0.0094 0.0725 0.0725
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0187 0.0182
Mycobacterium ulcerans carboxylesterase, LipT 0.0094 0.0725 0.8072
Schistosoma mansoni lipase 0.002 0.0005 0.0009
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0022 0.0028 0.0028
Plasmodium falciparum lipase, putative 0.002 0.0005 0.0043
Plasmodium vivax histone deacetylase 2, putative 0.0053 0.0329 0.2756
Leishmania major histone deacetylase, putative 0.0053 0.0329 0.0324
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.0854 0.1116
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0187 0.0182
Echinococcus multilocularis protein tyrosine kinase 0.0245 0.2201 0.2201
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0062 0.0412 0.0407
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0094 0.0725 0.0725
Brugia malayi ecdysteroid receptor 0.0031 0.0111 0.0111
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0264 0.0259
Schistosoma mansoni protein kinase 0.0038 0.0181 0.0314
Plasmodium vivax histone deacetylase, putative 0.0053 0.0329 0.2756
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.0022 0.0022 0.0022
Echinococcus granulosus acetylcholinesterase 0.0554 0.522 0.522
Echinococcus granulosus histone deacetylase 8 0.0053 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0053 0.0329 0.0329
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.1044 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0406 0.0406
Onchocerca volvulus 0.002 0.0005 0.0005
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0222 0.1825
Schistosoma mansoni BC026374 protein (S09 family) 0.0094 0.0725 0.1258
Echinococcus granulosus lamin 0.0082 0.0612 0.0612
Schistosoma mansoni hypothetical protein 0.0576 0.5429 0.9419
Schistosoma mansoni ran 0.0042 0.0222 0.0385
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0111
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0854 0.1481
Echinococcus multilocularis histone deacetylase 6 0.0053 0.0329 0.0329
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0329 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0111 0.0111
Schistosoma mansoni coup transcription factor 0.0031 0.0111 0.0193
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0111 0.0193
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0111 0.0193
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0329 0.0324
Brugia malayi Lipase family protein 0.002 0.0005 0.0005
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0111 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0854 0.0849
Loa Loa (eye worm) hypothetical protein 0.0107 0.0854 0.0854
Echinococcus multilocularis musashi 0.0082 0.0612 0.0612
Loa Loa (eye worm) carboxylesterase 0.0094 0.0725 0.0725
Schistosoma mansoni histone deacetylase 1 2 3 0.0053 0.0329 0.057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0111 0.0111
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0038 0.0181 0.0181
Trichomonas vaginalis esterase, putative 0.0107 0.0854 0.0849
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0038 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0365 0.3371 0.3371
Schistosoma mansoni hypothetical protein 0.061 0.5764 1
Plasmodium vivax histone deacetylase 1, putative 0.0142 0.1193 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0198 0.0198
Onchocerca volvulus 0.0094 0.0725 0.0725
Trypanosoma cruzi histone deacetylase 1, putative 0.0142 0.1193 0.1188
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0022 0.0028 0.0028
Trypanosoma brucei lipase domain protein, putative 0.1044 1 1
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.002 0.0005 0.0005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0111 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0111 0.0111
Brugia malayi beta-lactamase 0.0107 0.0854 0.0854
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0111 0.0111
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0187 0.0182
Onchocerca volvulus 0.0082 0.0612 0.0612
Leishmania major histone deacetylase, putative 0.0142 0.1193 0.1188
Brugia malayi Neuronal symmetry protein 1 0.0203 0.179 0.179
Schistosoma mansoni ran 0.0042 0.0222 0.0385
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0465 0.0465
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0107 0.0854 0.0854
Schistosoma mansoni acetylcholinesterase 0.0094 0.0725 0.1258
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0114 0.0114
Schistosoma mansoni histone deacetylase 0.0142 0.1193 0.2069
Echinococcus multilocularis histone deacetylase 1 0.0142 0.1193 0.1193
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0111 0.0111
Onchocerca volvulus Huntingtin homolog 0.0365 0.3371 0.3371
Leishmania major histone deacetylase, putative 0.0142 0.1193 0.1188
Leishmania major importin beta-1 subunit, putative 0.0046 0.0264 0.0259
Loa Loa (eye worm) hypothetical protein 0.0107 0.0854 0.0854
Loa Loa (eye worm) histone deacetylase 3 0.0142 0.1193 0.1193
Echinococcus granulosus histone deacetylase 7 0.0053 0.0329 0.0329
Mycobacterium leprae conserved hypothetical protein 0.0107 0.0854 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0142 0.1193 0.1188
Plasmodium falciparum histone deacetylase, putative 0.0053 0.0329 0.2756
Schistosoma mansoni histone deacetylase hda2 0.0053 0.0329 0.057
Trichomonas vaginalis STE family protein kinase 0.0038 0.0181 0.0176
Mycobacterium ulcerans beta-lactamase 0.0107 0.0854 1
Mycobacterium ulcerans hypothetical protein 0.0107 0.0854 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0222 0.0217
Brugia malayi RNA, U transporter 1 0.0162 0.1397 0.1397
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0111 0.0111
Schistosoma mansoni inositol monophosphatase 0.0039 0.0187 0.0325
Loa Loa (eye worm) hypothetical protein 0.0038 0.0183 0.0183
Onchocerca volvulus 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0094 0.0725 0.0725
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2281 0.2277
Echinococcus granulosus BC026374 protein S09 family 0.0094 0.0725 0.0725
Echinococcus granulosus importin subunit beta 1 0.0057 0.0369 0.0369
Loa Loa (eye worm) lipase 0.002 0.0005 0.0005
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0222 0.0222
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0111 0.0111
Brugia malayi Histone deacetylase family protein 0.0053 0.0329 0.0329
Echinococcus multilocularis histone deacetylase 8 0.0053 0.0329 0.0329
Echinococcus granulosus acetylcholinesterase 0.0554 0.522 0.522
Mycobacterium ulcerans lipase LipD 0.0107 0.0854 1
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0022 0.0028 0.0023
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0222 0.0222
Trichomonas vaginalis lipase containing protein, putative 0.1044 1 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0612 0.0612
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0094 0.0725 0.0725
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0111 0.0111
Brugia malayi histone deacetylase 3 (HD3) 0.0142 0.1193 0.1193
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0107 0.0854 0.0854
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0187 0.0182
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0114 0.0114
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.1193 0.1188
Trypanosoma cruzi histone deacetylase 1, putative 0.0142 0.1193 0.1188
Schistosoma mansoni histone deacetylase hda2 0.0053 0.0329 0.057
Entamoeba histolytica p21-activated kinase 0.0038 0.0181 0.1479
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0155 0.0155
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0198 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0175 0.017
Loa Loa (eye worm) hypothetical protein 0.0554 0.522 0.522
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0094 0.0725 0.072
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0111 0.0111
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0094 0.0725 0.0725
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0022 0.0028 0.0023
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0111 0.0111
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0111 0.0111
Trypanosoma brucei histone deacetylase 1 0.0142 0.1193 0.1188
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1432 0.1427
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0111 0.0111
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0187 0.0187
Trichomonas vaginalis ran, putative 0.0042 0.0222 0.0217
Loa Loa (eye worm) hypothetical protein 0.0145 0.1224 0.1224
Schistosoma mansoni intermediate filament proteins 0.0082 0.0612 0.1061
Mycobacterium tuberculosis Conserved protein 0.0107 0.0854 0.1116
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1432 0.1427
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0222 0.186
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.002 0.0005 0.0005
Echinococcus granulosus carboxylesterase 5A 0.0554 0.522 0.522
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.0854 0.1116
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0187 0.0182
Trypanosoma cruzi hypothetical protein, conserved 0.1044 1 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0094 0.0725 0.0725
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0854 0.0849
Loa Loa (eye worm) hypothetical protein 0.0057 0.0369 0.0369
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0111 0.0111
Echinococcus granulosus neuroligin 0.0094 0.0725 0.0725
Loa Loa (eye worm) TK/FAK protein kinase 0.0248 0.2229 0.2229
Mycobacterium tuberculosis Carboxylesterase LipT 0.0094 0.0725 0.0913
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0111 0.0111
Brugia malayi Lipase family protein 0.002 0.0005 0.0005
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0854 0.0849
Loa Loa (eye worm) histone deacetylase 1 0.0142 0.1193 0.1193
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.0062 0.0412 0.0412
Loa Loa (eye worm) inositol-1 0.0039 0.0187 0.0187
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0854 0.0849
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0111
Echinococcus multilocularis acetylcholinesterase 0.0554 0.522 0.522
Onchocerca volvulus 0.0094 0.0725 0.0725
Loa Loa (eye worm) histone deacetylase 0.0053 0.0329 0.0329
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0187 0.0182
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0142 0.1193 0.1188
Echinococcus granulosus histone deacetylase 6 0.0053 0.0329 0.0329
Loa Loa (eye worm) acetylcholinesterase 1 0.0554 0.522 0.522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0111 0.0111
Schistosoma mansoni gliotactin 0.0094 0.0725 0.1258
Loa Loa (eye worm) beta-lactamase 0.0107 0.0854 0.0854
Echinococcus granulosus intermediate filament protein 0.0082 0.0612 0.0612
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0854 0.0849
Toxoplasma gondii ABC1 family protein 0.0107 0.0854 0.7145
Trypanosoma brucei histone deacetylase, putative 0.0053 0.0329 0.0324
Toxoplasma gondii histone deacetylase HDAC5 0.0053 0.0329 0.2725
Schistosoma mansoni tyrosine kinase 0.0245 0.2201 0.3819
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.1193 0.1188
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0198 0.0198
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0098 0.0767 0.0767
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.0854 0.0854
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2281 0.2277
Loa Loa (eye worm) hypothetical protein 0.0037 0.0175 0.0175
Brugia malayi beta-lactamase family protein 0.0107 0.0854 0.0854
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0114 0.0114
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1432 0.1427
Schistosoma mansoni hypothetical protein 0.0067 0.0465 0.0806
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0038 0.0181 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0094 0.0725 0.0725
Echinococcus multilocularis histone deacetylase 6 0.0053 0.0329 0.0329
Schistosoma mansoni lamin 0.0082 0.0612 0.1061
Schistosoma mansoni histone deacetylase 4 5 0.0053 0.0329 0.057
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0111 0.0193
Echinococcus granulosus para nitrobenzyl esterase 0.0094 0.0725 0.0725
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0854 0.1481
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0111 0.0111
Onchocerca volvulus Histone deacetylase 10 homolog 0.0053 0.0329 0.0329
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0111 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0111 0.0111
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0111 0.0193
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0222 0.1825
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0111 0.0193
Toxoplasma gondii histone deacetylase HDAC1 0.0053 0.0329 0.2725
Schistosoma mansoni hypothetical protein 0.0031 0.0114 0.0198
Trichomonas vaginalis spcc417.12 protein, putative 0.0094 0.0725 0.072
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0339 0.0339
Loa Loa (eye worm) histone deacetylase 11 0.0053 0.0329 0.0329
Schistosoma mansoni importin beta-1 0.0057 0.0369 0.064
Leishmania major hypothetical protein, conserved 0.1044 1 1
Schistosoma mansoni protein kinase 0.0038 0.0181 0.0314
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0222 0.186
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0111 0.0111
Echinococcus multilocularis BC026374 protein (S09 family) 0.0094 0.0725 0.0725
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.0854 0.1116
Loa Loa (eye worm) lipase 0.002 0.0005 0.0005
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.0854 0.1116
Schistosoma mansoni lipoxygenase 0.0054 0.0339 0.0589
Entamoeba histolytica protein kinase, putative 0.0038 0.0181 0.1479
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0111
Onchocerca volvulus 0.0094 0.0725 0.0725
Brugia malayi intermediate filament protein 0.0082 0.0612 0.0612
Echinococcus multilocularis histone deacetylase 3 0.0142 0.1193 0.1193
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1519 0.1514
Onchocerca volvulus Huntingtin homolog 0.0365 0.3371 0.3371
Plasmodium falciparum histone deacetylase 1 0.0142 0.1193 1
Loa Loa (eye worm) hypothetical protein 0.0202 0.1784 0.1784
Echinococcus multilocularis muscleblind protein 0.0145 0.1224 0.1224
Schistosoma mansoni hypothetical protein 0.0031 0.0114 0.0198
Brugia malayi Inositol-1 0.0039 0.0187 0.0187
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0114 0.0114
Trypanosoma brucei lipase domain protein, putative 0.1044 1 1
Brugia malayi Lipase family protein 0.002 0.0005 0.0005
Schistosoma mansoni inositol monophosphatase 0.0039 0.0187 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0111 0.0111
Trypanosoma brucei histone deacetylase 3 0.0053 0.0329 0.0324
Echinococcus granulosus snurportin 1 0.061 0.5764 0.5764
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0264 0.0259
Brugia malayi histone deacetylase 1 (HD1) 0.0142 0.1193 0.1193
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0339 0.0339
Echinococcus multilocularis histone deacetylase 6 0.0053 0.0329 0.0329
Plasmodium vivax importin-beta 2, putative 0.0057 0.0369 0.3094
Brugia malayi Carboxylesterase family protein 0.0554 0.522 0.522
Loa Loa (eye worm) hypothetical protein 0.0142 0.1193 0.1193
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0111 0.0111
Echinococcus multilocularis lamin 0.0082 0.0612 0.0612
Brugia malayi Muscleblind-like protein 0.0145 0.1224 0.1224
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1432 0.1427
Entamoeba histolytica hypothetical protein 0.0046 0.0264 0.2176
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2281 0.2277
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.008 0.0597 0.0597
Entamoeba histolytica hypothetical protein 0.0035 0.0155 0.1266
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1432 0.1427
Onchocerca volvulus 0.1044 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0028 0.0049
Trichomonas vaginalis STE family protein kinase 0.0038 0.0181 0.0176
Trypanosoma brucei histone deacetylase 4 0.0053 0.0329 0.0324
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0111
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0264 0.0259
Loa Loa (eye worm) hypothetical protein 0.0094 0.0725 0.0725
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0222 0.0217
Brugia malayi Protein kinase domain 0.0038 0.0181 0.0181
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0264 0.0259
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0111 0.0111
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0142 0.1193 0.1188
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0329 0.0324
Brugia malayi Histone deacetylase 1 0.0142 0.1193 0.1193
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0187 0.0187
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.2281 0.2281
Echinococcus granulosus lamin dm0 0.0082 0.0612 0.0612
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0111 0.0111
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0767 0.0767
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0111 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.1044 1 1
Echinococcus granulosus GPCR family 2 0.0031 0.0114 0.0114
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0854 0.0849
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0203 0.179 0.179
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0111 0.0193
Trichomonas vaginalis STE family protein kinase 0.0038 0.0181 0.0176
Brugia malayi histone deacetylase 11 0.0053 0.0329 0.0329
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0369 0.0364
Brugia malayi Carboxylesterase family protein 0.0094 0.0725 0.0725
Mycobacterium tuberculosis Conserved protein 0.0107 0.0854 0.1116
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1432 0.1427
Toxoplasma gondii histone deacetylase HDAC2 0.0142 0.1193 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0111 0.0111
Loa Loa (eye worm) carboxylesterase 0.0094 0.0725 0.0725
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0612 0.0612
Loa Loa (eye worm) carboxylesterase 0.0554 0.522 0.522
Leishmania major histone deacetylase, putative 0.0053 0.0329 0.0324
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0111
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0038 0.0181 0.0181
Giardia lamblia Histone deacetylase 0.0142 0.1193 1
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.0854 0.1116
Brugia malayi nuclear receptor NHR-88 0.0031 0.0111 0.0111
Plasmodium vivax hypothetical protein, conserved 0.002 0.0005 0.0043
Entamoeba histolytica hypothetical protein 0.0035 0.0155 0.1266
Echinococcus multilocularis snurportin 1 0.061 0.5764 0.5764
Loa Loa (eye worm) hypothetical protein 0.0107 0.0854 0.0854
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.024 0.024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0111 0.0111
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0187 0.0182
Brugia malayi Carboxylesterase family protein 0.0094 0.0725 0.0725
Echinococcus granulosus muscleblind protein 0.0145 0.1224 0.1224
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0807 0.7689 0.7689
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1432 0.1427
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0111 0.0111
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0682 0.647 1
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0854 0.0849
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0062 0.0412 0.0407
Brugia malayi nuclear hormone receptor 0.0031 0.0111 0.0111
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0111 0.0111
Echinococcus multilocularis GPCR, family 2 0.0031 0.0114 0.0114
Onchocerca volvulus 0.0107 0.0854 0.0854
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0111 0.0193
Loa Loa (eye worm) hypothetical protein 0.0038 0.0183 0.0183
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0111 0.0111
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0022 0.0028 0.0028
Echinococcus multilocularis carboxylesterase 5A 0.0554 0.522 0.522
Loa Loa (eye worm) hypothetical protein 0.0031 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0111 0.0111
Trypanosoma cruzi p21-activated kinase 3, putative 0.0022 0.0028 0.0023
Leishmania major hypothetical protein, conserved 0.0107 0.0854 0.0849
Schistosoma mansoni lamin 0.0082 0.0612 0.1061
Loa Loa (eye worm) hypothetical protein 0.0067 0.0465 0.0465
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.0854 0.1116
Mycobacterium leprae Probable lipase LipE 0.0107 0.0854 1
Plasmodium falciparum importin beta, putative 0.0057 0.0369 0.3094
Loa Loa (eye worm) hypothetical protein 0.0554 0.522 0.522
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0111 0.0111
Echinococcus granulosus histone deacetylase 6 0.0053 0.0329 0.0329
Schistosoma mansoni protein kinase 0.0203 0.179 0.3104
Mycobacterium tuberculosis Conserved protein 0.0107 0.0854 0.1116
Brugia malayi Carboxylesterase family protein 0.0554 0.522 0.522
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0094 0.0725 0.1258
Loa Loa (eye worm) histone deacetylase 7A 0.0053 0.0329 0.0329
Onchocerca volvulus 0.0107 0.0854 0.0854
Entamoeba histolytica histone deacetylase, putative 0.0142 0.1193 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0155 0.0155
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0094 0.0725 0.1258
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1224 0.1224
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.1193 0.1188
Onchocerca volvulus 0.0094 0.0725 0.0725

Activities

Activity type Activity value Assay description Source Reference
GR50 (functional) = 53 ppm Herbicidal activity against Arabidopsis thaliana after 3 weeks ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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