Detailed information for compound 1814433

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 438.223 | Formula: C18H14BrF2N3O3
  • H donors: 2 H acceptors: 2 LogP: 3.81 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: BrCC1ON=C(C1)c1ccc(cc1)NC(=O)NC(=O)c1c(F)cccc1F
  • InChi: 1S/C18H14BrF2N3O3/c19-9-12-8-15(24-27-12)10-4-6-11(7-5-10)22-18(26)23-17(25)16-13(20)2-1-3-14(16)21/h1-7,12H,8-9H2,(H2,22,23,25,26)
  • InChiKey: LUZXJWSFDYIWLC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lamin dm0 0.0091 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0043
Loa Loa (eye worm) intermediate filament protein 0.0091 0.022 0.026
Entamoeba histolytica cysteine proteinase, putative 0.0028 0.0037 0.3182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0077 0.5558
Schistosoma mansoni microtubule-associated protein tau 0.3442 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.006 0.0131 0.0133
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0034 0.0054 0.0527
Echinococcus multilocularis cysteine protease 0.0042 0.0077 0.0077
Giardia lamblia GTOR 0.0034 0.0054 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0077 0.5558
Brugia malayi MH1 domain containing protein 0.0027 0.0033 0.0018
Brugia malayi Papain family cysteine protease containing protein 0.0042 0.0077 0.007
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0042 0.0077 0.0077
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0033 0.0039
Brugia malayi Latrophilin receptor protein 2 0.0028 0.0036 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.004 0.2553
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0018 0.0742
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0042 0.0077 0.5558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0034 0.2079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0077 0.5558
Schistosoma mansoni tar DNA-binding protein 0.0214 0.0581 0.0581
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0077 0.5558
Loa Loa (eye worm) hypothetical protein 0.0026 0.0033 0.0038
Echinococcus granulosus cysteine protease 0.0021 0.0018 0.0018
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0034 0.0054 0.1133
Brugia malayi Smad1 0.0027 0.0033 0.0018
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0034 0.0054 0.0527
Echinococcus granulosus fetal alzheimer antigen falz 0.002 0.0014 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0077 0.5558
Onchocerca volvulus Cathepsin L homolog 0.0042 0.0077 0.2353
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0037 0.2274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0418 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0077 0.5558
Trypanosoma cruzi cysteine peptidase, putative 0.0158 0.0418 1
Echinococcus multilocularis tumor protein p63 0.0543 0.1538 0.1538
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.0036 0.0036
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0054 0.0112 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0029 0.166
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0025 0.133
Onchocerca volvulus Cathepsin L homolog 0.0042 0.0077 0.2353
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0054 0.0043
Brugia malayi MH2 domain containing protein 0.0027 0.0033 0.0018
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0042 0.0077 1
Echinococcus multilocularis Smad4 0.0027 0.0033 0.0033
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0034 0.0054 0.0054
Trypanosoma cruzi target of rapamycin kinase 3 0.0027 0.0034 0.0411
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0043
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0033 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0077 0.5558
Leishmania major cathepsin L-like protease 0.0042 0.0077 0.1106
Loa Loa (eye worm) hypothetical protein 0.0037 0.0062 0.0073
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0088 0.0212 0.025
Brugia malayi RNA binding protein 0.0214 0.0581 0.0665
Echinococcus granulosus smad 0.0027 0.0033 0.0033
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0034 0.0054 0.1258
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.0036 0.0043
Entamoeba histolytica cysteine protease, putative 0.0042 0.0077 1
Onchocerca volvulus 0.0079 0.0187 0.8227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0418 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0034 0.2079
Loa Loa (eye worm) heterochromatin protein 1 0.006 0.0131 0.0154
Schistosoma mansoni hypothetical protein 0.006 0.0131 0.0131
Toxoplasma gondii cathepsin CPL 0.0042 0.0077 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0032 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0077 0.5558
Brugia malayi chromobox protein homolog 3 0.0034 0.0054 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0077 0.5558
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0214 0.0581 0.0685
Echinococcus granulosus tumor protein p63 0.0543 0.1538 0.1538
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0054 0.0112 0.0112
Onchocerca volvulus Cathepsin F homolog 0.0042 0.0077 0.2353
Echinococcus multilocularis tar DNA binding protein 0.0214 0.0581 0.0581
Trypanosoma cruzi cysteine peptidase, putative 0.0158 0.0418 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0077 0.5558
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0054 0.3683
Loa Loa (eye worm) hypothetical protein 0.0042 0.0077 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0054 0.374
Schistosoma mansoni hypothetical protein 0.0019 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0418 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.0036 0.0036
Brugia malayi MH2 domain containing protein 0.0027 0.0033 0.0018
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0034 0.0054 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0015 0.0474
Schistosoma mansoni lamin 0.0091 0.022 0.022
Echinococcus multilocularis microtubule associated protein 2 0.3442 1 1
Schistosoma mansoni chromobox protein 0.006 0.0131 0.0131
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0032 0.0049 0.0049
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0034 0.0054 0.6225
Brugia malayi Bromodomain containing protein 0.0067 0.0152 0.0158
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0021 0.0018 0.0018
Loa Loa (eye worm) Smad1 0.0027 0.0033 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0014 0.0426
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.002 0.0014 0.0014
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0036 0.0061 0.1531
Echinococcus granulosus cathepsin l1 0.0028 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0214 0.0581 0.0581
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0027 0.0034 0.0771
Schistosoma mansoni zinc finger protein 0.0018 0.0007 0.0007
Brugia malayi cathepsin L-like precursor 0.0028 0.0037 0.0022
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0044 0.0083 0.0083
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.2921 0.848 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0077 0.5558
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0091 0.022 0.026
Schistosoma mansoni tar DNA-binding protein 0.0214 0.0581 0.0581
Onchocerca volvulus 0.0042 0.0077 0.2353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0029 0.166
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0054 0.3683
Echinococcus multilocularis musashi 0.0091 0.022 0.022
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0091 0.022 0.026
Onchocerca volvulus 0.0042 0.0077 0.2353
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0077 0.5558
Schistosoma mansoni tar DNA-binding protein 0.0214 0.0581 0.0581
Entamoeba histolytica cysteine proteinase, putative 0.0042 0.0077 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0014 0.0426
Onchocerca volvulus 0.0091 0.022 1
Onchocerca volvulus 0.0042 0.0077 0.2353
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0077 0.5558
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0092
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0044 0.0083 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0015 0.0474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0028 0.0037 0.2274
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0077 0.5558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0021 0.0018 0.0742
Echinococcus granulosus cathepsin L 0.0021 0.0018 0.0018
Onchocerca volvulus 0.0091 0.022 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0018 0.0376
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0418 1
Brugia malayi Cathepsin L-like precursor 0.0028 0.0037 0.0022
Loa Loa (eye worm) hypothetical protein 0.2921 0.848 1
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0022 0.1068
Echinococcus granulosus intermediate filament protein 0.0091 0.022 0.022
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0021 0.0018 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0418 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0418 1
Loa Loa (eye worm) transcription factor SMAD2 0.0389 0.1091 0.1287
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0145 0.0378 0.8997
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0088 0.0212 0.025
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0092
Brugia malayi cytoplasmic intermediate filament protein 0.0049 0.0097 0.0094
Leishmania major cysteine peptidase A (CPA) 0.0042 0.0077 0.1106
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0044 0.0083 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0077 0.5558
Brugia malayi Calcitonin receptor-like protein seb-1 0.0088 0.0212 0.0229
Schistosoma mansoni hypothetical protein 0.0028 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0077 0.5558
Onchocerca volvulus 0.0028 0.0037 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0007
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.2921 0.848 0.848
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.2921 0.848 0.848
Echinococcus granulosus GPCR family 2 0.0028 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0042 0.0077 0.5558
Brugia malayi MH2 domain containing protein 0.0389 0.1091 0.1268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0077 0.5558
Echinococcus multilocularis lamin dm0 0.0091 0.022 0.022
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0042 0.0077 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0021 0.0018 0.0376
Brugia malayi Cathepsin L-like precursor 0.0042 0.0077 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0418 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0187 0.0221
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0021 0.0018 0.0018
Brugia malayi RNA recognition motif domain containing protein 0.0214 0.0581 0.0665
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0077 0.5558
Onchocerca volvulus 0.0042 0.0077 0.2353
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0043
Brugia malayi Cathepsin L-like cysteine proteinase 0.0028 0.0037 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0061 0.4295
Onchocerca volvulus 0.0042 0.0077 0.2353
Echinococcus granulosus tar DNA binding protein 0.0214 0.0581 0.0581
Schistosoma mansoni smad1 5 8 and 0.0027 0.0033 0.0033
Echinococcus multilocularis lamin 0.0091 0.022 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0007
Loa Loa (eye worm) RNA binding protein 0.0214 0.0581 0.0685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0077 0.5558
Leishmania major cathepsin L-like protease 0.0158 0.0418 1
Brugia malayi Cathepsin L-like precursor 0.0042 0.0077 0.007
Brugia malayi Bromodomain containing protein 0.0034 0.0056 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0034 0.2079
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0028 0.0036 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0034 0.2079
Echinococcus granulosus cathepsin l1 0.0042 0.0077 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0214 0.0581 0.0581
Echinococcus multilocularis chromobox protein 1 0.006 0.0131 0.0131
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0088 0.0212 0.0229
Leishmania major cathepsin L-like protease 0.0042 0.0077 0.1106
Onchocerca volvulus 0.0042 0.0077 0.2353
Loa Loa (eye worm) hypothetical protein 0.0063 0.0141 0.0166
Schistosoma mansoni smad1 5 8 and 0.0027 0.0033 0.0033
Brugia malayi PHD-finger family protein 0.0022 0.0021 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0418 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0418 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0015 0.0474
Echinococcus multilocularis cathepsin L 0.0021 0.0018 0.0018
Schistosoma mansoni smad1 5 8 and 0.0027 0.0033 0.0033
Trypanosoma cruzi major cysteine proteinase, putative 0.0125 0.0319 0.7525
Trypanosoma cruzi cysteine peptidase, putative 0.0158 0.0418 1
Trypanosoma cruzi cysteine peptidase, putative 0.0042 0.0077 0.1472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0029 0.166
Leishmania major cathepsin L-like protease 0.0042 0.0077 0.1106
Echinococcus granulosus lamin 0.0091 0.022 0.022
Schistosoma mansoni lamin 0.0091 0.022 0.022
Schistosoma mansoni cathepsin F (C01 family) 0.0042 0.0077 0.0077
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0049 0.0097 0.0115
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0037 0.0037
Echinococcus granulosus cathepsin l cysteine peptidase 0.0042 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0034 0.0056 0.0066
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.0036 0.0036
Schistosoma mansoni cellular tumor antigen P53 0.0079 0.0187 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0025 0.133
Echinococcus multilocularis GPCR, family 2 0.0028 0.0036 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0029 0.166
Schistosoma mansoni cathepsin F (C01 family) 0.0042 0.0077 0.0077
Echinococcus granulosus chromobox protein 1 0.006 0.0131 0.0131
Brugia malayi TAR-binding protein 0.0214 0.0581 0.0665
Echinococcus multilocularis cathepsin L cysteine protease 0.0042 0.0077 0.0077
Leishmania major cathepsin L-like protease 0.0158 0.0418 1
Trichomonas vaginalis chromobox protein, putative 0.006 0.0131 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0077 0.5558
Brugia malayi Cathepsin L-like precursor 0.0028 0.0037 0.0022
Echinococcus multilocularis cathepsin L cysteine protease 0.0042 0.0077 0.0077
Trichomonas vaginalis chromobox protein, putative 0.006 0.0131 1
Echinococcus granulosus chromobox protein 1 0.006 0.0131 0.0131
Echinococcus granulosus cathepsin L cysteine protease 0.0021 0.0018 0.0018
Schistosoma mansoni intermediate filament proteins 0.0091 0.022 0.022
Trypanosoma cruzi cruzipain precursor, putative 0.0158 0.0418 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0389 0.1091 0.1287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.002 0.0893
Loa Loa (eye worm) fibroinase 0.0042 0.0077 0.009
Echinococcus granulosus Smad4 0.0027 0.0033 0.0033
Leishmania major cathepsin L-like protease 0.0042 0.0077 0.1106
Schistosoma mansoni bromodomain containing protein 0.0057 0.0121 0.0121
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0061 0.4295
Loa Loa (eye worm) cysteine protease 0.0042 0.0077 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0034 0.2079
Brugia malayi Intermediate filament tail domain containing protein 0.0091 0.022 0.0239
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0042 0.0077 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0054 0.374
Loa Loa (eye worm) hypothetical protein 0.006 0.0131 0.0154
Loa Loa (eye worm) bromodomain containing protein 0.0016 0.0002 0.0002
Leishmania major cathepsin L-like protease 0.0158 0.0418 1
Echinococcus multilocularis chromobox protein 1 0.006 0.0131 0.0131
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0033 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0009 0.0007
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0009 0.0011
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0033 0.0033
Echinococcus multilocularis smad 0.0027 0.0033 0.0033
Echinococcus granulosus zinc finger protein 0.0018 0.0007 0.0007
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0034 0.0054 0.0916
Brugia malayi Cathepsin L-like precursor 0.0042 0.0077 0.007
Echinococcus multilocularis zinc finger protein 0.0018 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0054 0.374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0077 0.5558
Leishmania major cathepsin L-like protease 0.0042 0.0077 0.1106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0029 0.166
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0034 0.0054 0.0054
Schistosoma mansoni Smad4 0.0027 0.0033 0.0033
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0034 0.0054 0.1258
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0038 0.0067 0.0079
Brugia malayi Heterochromatin protein 1 0.006 0.0131 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0029 0.166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0042 0.0077 0.5558
Onchocerca volvulus 0.0042 0.0077 0.2353
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0034 0.0054 0.6225
Schistosoma mansoni chromobox protein 0.006 0.0131 0.0131
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.2921 0.848 0.848
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0033 0.0033
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0042 0.0077 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0029 0.166
Loa Loa (eye worm) phosphatidylinositol 3 0.0034 0.0054 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0418 1
Brugia malayi MH1 domain containing protein 0.0027 0.0033 0.0018
Plasmodium falciparum cysteine proteinase falcipain 3 0.0042 0.0077 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0042 0.0077 0.0077
Loa Loa (eye worm) ctsf protein 0.0042 0.0077 0.009
Loa Loa (eye worm) TAR-binding protein 0.0214 0.0581 0.0685
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0043
Schistosoma mansoni smad 0.0027 0.0033 0.0033
Brugia malayi intermediate filament protein 0.0091 0.022 0.0239
Plasmodium vivax vivapain-2 0.0042 0.0077 1
Entamoeba histolytica cysteine proteinase, putative 0.0042 0.0077 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0215 0.0254
Plasmodium vivax vivapain-2 0.0042 0.0077 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.002 0.0014 0.0014
Brugia malayi Cathepsin L-like precursor 0.0042 0.0077 0.007
Brugia malayi Cathepsin L-like precursor 0.0042 0.0077 0.007
Brugia malayi Cathepsin L-like precursor 0.0042 0.0077 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0158 0.0418 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0034 0.0054 0.0916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0042 0.0077 0.5558
Echinococcus multilocularis cysteine protease 0.0042 0.0077 0.0077
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0042 0.0077 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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