TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 283.406 | Formula: C16H29NO3
H donors: 1 H acceptors: 2 LogP: 3.32 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)C1C(=O)CC(NC1C(C)(C)C)C(C)(C)C
InChi: 1S/C16H29NO3/c1-8-20-14(19)12-10(18)9-11(15(2,3)4)17-13(12)16(5,6)7/h11-13,17H,8-9H2,1-7H3
InChiKey: WDULTXCKYVVYNM-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0022	0.0053	0.1355
Echinococcus granulosus	transient receptor potential cation channel	0.0011	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Leishmania major	hypothetical protein, unknown function	0.0022	0.0053	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.001	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0054	0.0054
Treponema pallidum	catabolite gene activator	0.0022	0.0053	0.5
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0033	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0022	0.0053	0.0053
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0147	0.0147
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0033	0.0092	0.0092
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.003	0.0024
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.001	0.001
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0011	0.0014	0.0008
Schistosoma mansoni	hypothetical protein	0.0022	0.0053	0.0053
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0033	0.0092	0.0092
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0011	0.0014	0.0008
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0304	1
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0022	0.0053	0.0053
Leishmania major	protein kinase, putative	0.0022	0.0054	0.1392
Schistosoma mansoni	60S ribosomal protein L21	0.0026	0.0069	0.0069
Echinococcus granulosus	voltage dependent calcium channel	0.0011	0.0014	0.0014
Schistosoma mansoni	hypothetical protein	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Schistosoma mansoni	cpg binding protein	0.003	0.0081	0.0081
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.0304	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0193	0.0656	0.0656
Schistosoma mansoni	cpg binding protein	0.0028	0.0075	0.0075
Trypanosoma cruzi	protein kinase A regulatory subunit	0.0022	0.0053	0.1355
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0022	0.0053	0.0053
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0006	0.0006
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0022	0.0053	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.001	0.001
Brugia malayi	N-terminal motif family protein	0.0022	0.0053	0.0048
Schistosoma mansoni	thyroid hormone receptor	0.001	0.001	0.001
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.001	0.0004
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0033	0.0092	0.0086
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0011	0.0014	0.0014
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0011	0.0014	0.0014
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0022	0.0053	0.1355
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0147	0.0147
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0016	0.0031	0.057
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Echinococcus multilocularis	calcium activated potassium channel	0.0011	0.0015	0.0015
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0022	0.0053	0.0053
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0053	0.5
Trypanosoma cruzi	cAMP binding protein, putative	0.0022	0.0053	0.1355
Schistosoma mansoni	transient receptor potential channel 4	0.0011	0.0014	0.0014
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.001	0.001
Echinococcus granulosus	short transient receptor potential channel 6	0.0011	0.0014	0.0014
Echinococcus granulosus	transient receptor potential cation channel	0.0011	0.0014	0.0014
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0011	0.0014	0.0014
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0022	0.0054	0.0054
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0149	0.0143
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0022	0.0053	0.0053
Giardia lamblia	Kinase, PLK	0.0093	0.0304	1
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0053	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.001	0.001
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0022	0.0053	0.0868
Loa Loa (eye worm)	hypothetical protein	0.001	0.001	0.0004
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0022	0.0053	0.5
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0022	0.0053	0.1355
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0033	0.0092	0.0092
Echinococcus multilocularis	alpha 1,6 mannosyl glycoprotein	0.2842	1	1
Echinococcus granulosus	single minded 2	0.0015	0.003	0.003
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0022	0.0053	0.2611
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.001	0.001
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0134	0.0129
Echinococcus multilocularis	GPCR, family 2	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.001	0.001	0.0004
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0134	0.0134
Echinococcus granulosus	TRP transient receptor potential channel	0.0011	0.0014	0.0014
Schistosoma mansoni	serine/threonine protein kinase	0.0093	0.0304	0.0304
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0022	0.0053	0.0053
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0011	0.0014	0.0014
Mycobacterium leprae	Conserved hypothetical protein	0.0022	0.0053	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0011	0.0014	0.0014
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0022	0.0053	0.2611
Brugia malayi	ion channel NompC	0.0011	0.0014	0.0008
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0014	0.0014
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Echinococcus multilocularis	transient receptor potential cation channel	0.0011	0.0014	0.0014
Brugia malayi	Transient-receptor-potential like protein	0.0011	0.0014	0.0008
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0022	0.0054	0.0054
Treponema pallidum	cyclic nucleotide binding protein	0.0022	0.0053	0.5
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0011	0.0014	0.0008
Loa Loa (eye worm)	ryanodine receptor	0.0011	0.0014	0.0008
Schistosoma mansoni	hypothetical protein	0.0015	0.003	0.003
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0011	0.0014	0.0014
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0022	0.0053	0.0868
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0011	0.0014	0.0014
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0022	0.0053	0.0053
Mycobacterium tuberculosis	Conserved protein	0.0022	0.0053	0.5
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0011	0.0014	0.0014
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0022	0.0053	0.0048
Loa Loa (eye worm)	voltage-gated potassium channel	0.0011	0.0014	0.0008
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0011	0.0014	0.0014
Echinococcus multilocularis	voltage dependent calcium channel	0.0011	0.0014	0.0014
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.001	0.0005
Echinococcus multilocularis	ryanodine receptor 44f	0.0011	0.0014	0.0014
Echinococcus granulosus	cpg binding protein	0.003	0.0081	0.0081
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0193	0.0656	0.0656
Echinococcus granulosus	voltage gated potassium channel	0.0049	0.0147	0.0147
Echinococcus granulosus	two pore calcium channel protein 2	0.0011	0.0014	0.0014
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0014	0.0014
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0093	0.0304	0.0298
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0022	0.0053	0.0053
Brugia malayi	nuclear hormone receptor	0.001	0.001	0.0005
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0022	0.0053	0.0053
Echinococcus granulosus	potassium voltage gated channel protein	0.0011	0.0014	0.0014
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.003	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0014	0.0014
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0075	0.0069
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0011	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.001	0.001
Brugia malayi	hypothetical protein	0.0011	0.0014	0.0008
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0049	0.0147	0.0141
Echinococcus granulosus	potassium voltage gated channel protein	0.0011	0.0014	0.0014
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0134	0.0128
Echinococcus multilocularis	transient receptor potential cation channel	0.0011	0.0014	0.0014
Echinococcus granulosus	shaker cognate	0.0011	0.0014	0.0014
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Echinococcus granulosus	GPCR family 2	0.0016	0.003	0.003
Schistosoma mansoni	beta-12-n-acetylglucosaminyltransferase II	0.2842	1	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0147	0.0141
Schistosoma mansoni	transient receptor potential channel	0.0011	0.0014	0.0014
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0011	0.0014	0.0014
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0014	0.0014
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0011	0.0014	0.0014
Echinococcus granulosus	hyperpolarization activated cyclic	0.0033	0.0092	0.0092
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0011	0.0014	0.0008
Echinococcus multilocularis	sodium channel protein	0.0011	0.0014	0.0014
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0022	0.0054	0.0054
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0075	0.0069
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0022	0.0053	0.5
Schistosoma mansoni	cpg binding protein	0.003	0.0081	0.0081
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0053	0.0868
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0092	0.229
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0015	0.003	0.0024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.001	0.0004
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0014	0.0014
Schistosoma mansoni	kinase	0.0047	0.0142	0.0142
Schistosoma mansoni	calcium-activated potassium channel	0.0011	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.001	0.001	0.0004
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0093	0.0304	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0149	0.0143
Echinococcus granulosus	sodium channel protein	0.0011	0.0014	0.0014
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.001	0.001
Onchocerca volvulus		0.0022	0.0053	0.1467
Brugia malayi	cation channel family protein	0.0011	0.0014	0.0008
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.003	0.003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.001	0.0004
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0011	0.0014	0.0014
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.001	0.0005
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.0092	0.229
Echinococcus multilocularis	potassium large conductance calcium activated	0.0011	0.0014	0.0014
Echinococcus multilocularis	short transient receptor potential channel 6	0.0011	0.0014	0.0014
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0011	0.0014	0.0014
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0033	0.0092	0.0092
Trypanosoma brucei	cAMP response protein 1, putative	0.0022	0.0053	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0016	0.003	0.0024
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.001	0.001
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0033	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.2842	1	1
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0011	0.0014	0.0014
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0134	0.0134
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0011	0.0014	0.0014
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0011	0.0014	0.0014
Schistosoma mansoni	hypothetical protein	0.0404	0.1399	0.1399
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.001	0.0004
Brugia malayi	voltage-dependent calcium channel	0.0011	0.0014	0.0008
Onchocerca volvulus		0.0028	0.0075	0.2207
Schistosoma mansoni	coup transcription factor	0.001	0.001	0.001
Brugia malayi	cation channel family protein	0.0011	0.0014	0.0008
Schistosoma mansoni	nuclear hormone receptor	0.001	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0304	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0014	0.0014
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0053	0.1355
Trypanosoma cruzi	cAMP response protein 1, putative	0.0022	0.0053	0.1355
Echinococcus multilocularis	transfer RNA-Gly	0.0011	0.0014	0.0014
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0304	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0053	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0022	0.0053	0.0868
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0134	0.0134
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0094	0.0088
Trypanosoma brucei	protein kinase A regulatory subunit	0.0022	0.0053	0.1355
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0011	0.0014	0.0014
Onchocerca volvulus		0.0011	0.0014	0.013
Echinococcus granulosus	cGMP dependent protein kinase	0.0022	0.0054	0.0054
Echinococcus granulosus	ryanodine receptor 44f	0.0011	0.0014	0.0014
Echinococcus granulosus	FTZ F1 alpha	0.001	0.001	0.001
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0093	0.0304	0.0304
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0011	0.0014	0.0014
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0138	0.3948
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0053	0.5
Mycobacterium ulcerans	transmembrane transport protein	0.0022	0.0053	0.5
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0022	0.0054	0.0054
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.001	0.001	0.0004
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0033	0.0092	0.0092
Echinococcus multilocularis	transient receptor potential cation channel	0.0011	0.0014	0.0014
Echinococcus granulosus	potassium voltage gated channel protein	0.0011	0.0014	0.0014
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0022	0.0053	0.0048
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0011	0.0014	0.0014
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0011	0.0014	0.0014
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0033	0.0092	0.0086
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0022	0.0053	0.5
Brugia malayi	serine/threonine-protein kinase plk-2	0.0093	0.0304	0.0298
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0011	0.0014	0.0014
Schistosoma mansoni	hypothetical protein	0.0016	0.003	0.003
Loa Loa (eye worm)	ion channel NompC	0.0011	0.0014	0.0008
Echinococcus multilocularis	voltage dependent calcium channel	0.0011	0.0014	0.0014
Trypanosoma brucei	polo-like protein kinase	0.0093	0.0304	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0093	0.0304	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0011	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0033	0.0092	0.0092
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.001	0.001	0.0004
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0022	0.0053	0.0053
Leishmania major	hypothetical protein, conserved	0.0022	0.0053	0.1355
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0033	0.0092	0.0087
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.001	0.0005
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0134	0.0134
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0011	0.0014	0.0008
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0134	0.0134
Echinococcus multilocularis	transient receptor potential gamma protein	0.0011	0.0014	0.0014
Leishmania major	protein kinase A regulatory subunit, putative	0.0022	0.0053	0.1355
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0187	0.0187
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0022	0.0053	0.0053
Schistosoma mansoni	hypothetical protein	0.0011	0.0014	0.0014
Echinococcus multilocularis	sodium leak channel non selective protein	0.0011	0.0014	0.0014
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0006	0.0006
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0138	0.3948
Loa Loa (eye worm)	hypothetical protein	0.001	0.001	0.0004
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0053	0.0047
Echinococcus multilocularis	two pore calcium channel protein 1	0.0011	0.0014	0.0014
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0011	0.0014	0.0008
Echinococcus multilocularis	conserved hypothetical protein	0.0011	0.0014	0.0014
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0011	0.0014	0.0014
Schistosoma mansoni	voltage-gated cation channel	0.0011	0.0014	0.0014
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0033	0.0092	0.0092
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.003	0.0024
Trypanosoma brucei	Flagellar Member 6	0.0022	0.0053	0.1355
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.001	0.001
Echinococcus granulosus	transient receptor potential gamma protein	0.0011	0.0014	0.0014
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0022	0.0053	0.0048
Schistosoma mansoni	hypothetical protein	0.0016	0.003	0.003
Echinococcus multilocularis	cpg binding protein	0.003	0.0081	0.0081
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.001	0.001
Treponema pallidum	catabolite gene activator (Crp)	0.0022	0.0053	0.5
Schistosoma mansoni	voltage-gated ion channel	0.0011	0.0014	0.0014
Schistosoma mansoni	ryanodine receptor related	0.0011	0.0014	0.0014
Onchocerca volvulus		0.0022	0.0053	0.1467
Schistosoma mansoni	voltage-gated potassium channel	0.0171	0.0577	0.0577
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0022	0.0053	0.5
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.001	0.001
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.001	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.001	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.001	0.0005
Echinococcus granulosus	alpha 16 mannosyl glycoprotein	0.2842	1	1
Brugia malayi	olfactory channel protein osm-9	0.0011	0.0014	0.0008
Echinococcus granulosus	potassium voltage gated channel protein	0.0011	0.0014	0.0014
Echinococcus multilocularis	dnaJ subfamily B	0.0404	0.1399	0.1399
Schistosoma mansoni	transient receptor potential channel	0.0011	0.0014	0.0014
Loa Loa (eye worm)	voltage-gated calcium channel	0.0011	0.0014	0.0008
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0011	0.0014	0.0014
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.001	0.0005
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.001	0.0005
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0149	0.0143
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.001	0.0005
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0022	0.0053	0.1355
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0011	0.0014	0.0014
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0011	0.0014	0.0008
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0011	0.0014	0.0014
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0053	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0094	0.0088
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0022	0.0053	0.0053
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0093	0.0304	0.5
Echinococcus multilocularis	potassium voltage gated channel protein	0.0011	0.0014	0.0014
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0033	0.0092	0.0092
Schistosoma mansoni	voltage-dependent calcium channel	0.0011	0.0014	0.0014
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0011	0.0014	0.013
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0011	0.0014	0.0008
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0304	1
Trypanosoma cruzi	cAMP response protein 1	0.0022	0.0053	0.1355
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0022	0.0053	0.0053
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.003	0.003
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.003	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0304	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0022	0.0053	0.0053
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0054	0.0054
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0033	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.001	0.001	0.0004
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0011	0.0014	0.0014
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.001	0.0005
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0011	0.0014	0.0014
Schistosoma mansoni	two-pore calcium channel	0.0011	0.0014	0.0014
Echinococcus multilocularis	shaker cognate	0.0011	0.0014	0.0014
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0014	0.0014
Trypanosoma cruzi	Flagellar Member 6	0.0022	0.0053	0.1355
Leishmania major	hypothetical protein, conserved	0.0022	0.0053	0.1355
Echinococcus granulosus	voltage dependent calcium channel	0.0011	0.0014	0.0014
Echinococcus granulosus	potassium voltage gated channel protein	0.0011	0.0014	0.0014
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.001	0.001
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0147	0.0147
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0011	0.0014	0.0014
Brugia malayi	Egg laying defective protein 4	0.0022	0.0054	0.0049
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0022	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.001	0.001
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.001	0.001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.001	0.0004
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0165	1
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0011	0.0014	0.0008
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0011	0.0014	0.0014
Plasmodium falciparum	cGMP-dependent protein kinase	0.0022	0.0054	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0022	0.0053	0.0868
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0011	0.0014	0.0014
Echinococcus multilocularis	two pore calcium channel protein 2	0.0011	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.001	0.001	0.0004
Echinococcus granulosus	dnaJ subfamily B	0.0404	0.1399	0.1399
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.001	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0092	0.0086
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0014	0.0014
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0022	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.001	0.001
Schistosoma mansoni	hypothetical protein	0.0016	0.003	0.003
Echinococcus granulosus	short transient receptor potential channel 6	0.0011	0.0014	0.0014
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.0304	1
Echinococcus granulosus	transient receptor potential cation channel	0.0011	0.0014	0.0014
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0022	0.0053	0.0053
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0011	0.0014	0.0008
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0011	0.0014	0.0014
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.001	0.0005
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.001	0.001
Trypanosoma cruzi	cyclic nucleotide-binding domain containing protein, putative	0.0022	0.0053	0.1355
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.001	0.001
Schistosoma mansoni	thyroid hormone receptor	0.001	0.001	0.001
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0022	0.0053	0.0053
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0033	0.0092	0.0092
Schistosoma mansoni	hypothetical protein	0.0034	0.0094	0.0094
Brugia malayi	nuclear receptor NHR-88	0.001	0.001	0.0005
Treponema pallidum	cyclic nucleotide binding protein	0.0022	0.0053	0.5
Leishmania major	protein kinase, putative	0.0022	0.0054	0.1392
Brugia malayi	ecdysteroid receptor	0.001	0.001	0.0005
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0011	0.0014	0.0014
Brugia malayi	steroid hormone receptor	0.001	0.001	0.0005
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0022	0.0053	0.0868
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0022	0.0053	0.1467
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0022	0.0053	0.1355
Echinococcus granulosus	transient receptor potential cation channel	0.0011	0.0014	0.0014
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.001	0.0005
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0304	1
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0011	0.0014	0.0008
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0022	0.0053	0.0053
Trypanosoma cruzi	regulatory subunit of protein kinase a-like protein, putative	0.0022	0.0053	0.1355
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0011	0.0014	0.0014
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.001	0.001
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0011	0.0014	0.0014
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0022	0.0053	0.0053
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0022	0.0054	0.0048
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.001	0.0004
Echinococcus multilocularis	potassium voltage gated channel protein	0.0011	0.0014	0.0014
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0093	0.0304	0.0304
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0134	0.0134
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0149	0.0143
Echinococcus multilocularis	transient receptor potential cation channel	0.0011	0.0014	0.0014
Echinococcus granulosus	hyperpolarization activated cyclic	0.0033	0.0092	0.0092
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0033	0.0092	0.0087
Schistosoma mansoni	vesicular amine transporter	0.0011	0.0014	0.0014
Loa Loa (eye worm)	voltage-gated potassium channel	0.0011	0.0014	0.0008
Mycobacterium ulcerans	transcriptional regulatory protein	0.0022	0.0053	0.5
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0011	0.0014	0.0014
Echinococcus multilocularis	expressed conserved protein	0.0022	0.0054	0.0054
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0033	0.0092	0.0092
Schistosoma mansoni	voltage-gated potassium channel	0.0049	0.0147	0.0147
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0022	0.0053	0.0868
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0304	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0033	0.0092	0.0092
Echinococcus multilocularis	voltage gated potassium channel	0.0011	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Echinococcus multilocularis	short transient receptor potential channel 6	0.0011	0.0014	0.0014
Echinococcus multilocularis	voltage gated potassium channel	0.0049	0.0147	0.0147
Schistosoma mansoni	voltage-gated potassium channel	0.0033	0.0092	0.0092
Echinococcus granulosus	transient receptor potential cation channel	0.0011	0.0014	0.0014
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0033	0.0092	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.001	0.0005
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0014	0.0014
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.001	0.0004
Echinococcus granulosus	hypothetical protein	0.0011	0.0014	0.0014
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0022	0.0053	0.5
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0053	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0134	0.0134
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0011	0.0014	0.0014
Echinococcus granulosus	transient receptor potential cation channel	0.0011	0.0014	0.0014
Echinococcus multilocularis	potassium voltage gated channel protein	0.0011	0.0014	0.0014
Mycobacterium ulcerans	regulatory protein	0.0022	0.0053	0.5
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.001	0.001
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0022	0.0053	0.2611
Loa Loa (eye worm)	cAMP-dependent protein kinase regulatory subunit	0.0022	0.0053	0.0047
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0033	0.0092	0.0092
Loa Loa (eye worm)	calcium channel	0.0011	0.0014	0.0008
Toxoplasma gondii	cAMP-dependent protein kinase regulatory subunit	0.0022	0.0053	0.2611
Echinococcus granulosus	two pore calcium channel protein 1	0.0011	0.0014	0.0014
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0022	0.0054	0.2682
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0022	0.0053	0.0053
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0011	0.0014	0.0008
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0011	0.0014	0.0008
Echinococcus granulosus	voltage gated potassium channel	0.0011	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Echinococcus granulosus	sodium leak channel non selective protein	0.0011	0.0014	0.0014
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0053	0.0047
Echinococcus multilocularis	transient receptor potential cation channel	0.0011	0.0014	0.0014
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0022	0.0053	0.0053
Echinococcus granulosus	potassium large conductance calcium activated	0.0011	0.0014	0.0014
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.001	0.001
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0033	0.0092	0.0092
Toxoplasma gondii	cyclic nucleotide-binding domain-containing protein	0.0022	0.0053	0.2611
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.001	0.0005
Schistosoma mansoni	transient receptor potential channel	0.0011	0.0014	0.0014
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0011	0.0014	0.0008
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.001	0.001
Trypanosoma brucei	cAMP binding protein, putative	0.0022	0.0053	0.1355
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0011	0.0014	0.013
Leishmania major	hypothetical protein, conserved	0.0022	0.0053	0.1355
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.001	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0014	0.0008
Echinococcus granulosus	calcium activated potassium channel	0.0011	0.0015	0.0015
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0022	0.0053	0.5
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0022	0.0053	0.0053

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 64 ug ml-1	Antibacterial activity against Escherichia coli after 24 hr by serial dilution method	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2238305

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1816018