Detailed information for compound 1818120

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 465.497 | Formula: C29H23NO5
  • H donors: 2 H acceptors: 3 LogP: 4.58 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)N[C@H]([C@@H](c1ccccc1)O)c1ccccc1
  • InChi: 1S/C29H23NO5/c1-34-21-13-14-22-25(17-21)35-24-15-12-20(16-23(24)28(22)32)29(33)30-26(18-8-4-2-5-9-18)27(31)19-10-6-3-7-11-19/h2-17,26-27,31H,1H3,(H,30,33)/t26-,27+/m0/s1
  • InChiKey: LHAHDFIWRHSHGQ-RRPNLBNLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Tyrosine-protein kinase abl-1 0.0256 0.2348 1
Brugia malayi PHD-finger family protein 0.0015 0.0053 0.0225
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0041
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0016 0.0016
Schistosoma mansoni zinc finger protein 0.0017 0.0078 0.0078
Onchocerca volvulus 0.0031 0.0208 0.0778
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0228 0.4043
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0336 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0399 0.0987
Echinococcus multilocularis dna polymerase eta 0.0016 0.0061 0.0061
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0014 0.0042 0.0042
Echinococcus multilocularis c src tyrosine kinase 0.0014 0.0042 0.0042
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0014 0.0042 0.0042
Echinococcus granulosus tyrosine protein kinase Src42A 0.0014 0.0042 0.0042
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0016 0.0016
Schistosoma mansoni ap endonuclease 0.002 0.0106 0.0106
Schistosoma mansoni growth factor receptor-bound protein 0.0012 0.0026 0.0026
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0184 0.0468
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0268 0.7911
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0242 0.4303
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0016 0.0016
Schistosoma mansoni DNA polymerase eta 0.0016 0.0061 0.0061
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0184 0.0184
Echinococcus multilocularis zinc finger protein 0.0028 0.0179 0.0179
Brugia malayi steroid hormone receptor 0.0011 0.0016 0.0069
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0097 0.0097
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0061 0.1582
Leishmania major hypothetical protein, conserved 0.0017 0.0078 0.3905
Echinococcus granulosus dnaJ subfamily B 0.0444 0.4133 0.4133
Echinococcus granulosus dna polymerase eta 0.0016 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0336 1
Schistosoma mansoni adapter molecule crk 0.0012 0.0026 0.0026
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.0033 0.0723
Brugia malayi polk-prov protein 0.0034 0.0233 0.0991
Treponema pallidum fructose-bisphosphate aldolase 0.0333 0.308 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0208 0.053
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0014 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0075 0.0624 0.1587
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.106 0.9996 0.9996
Schistosoma mansoni hypothetical protein 0.0444 0.4133 0.4133
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0061 0.0061
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.106 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0015 0.0015
Loa Loa (eye worm) SRC-1 0.0014 0.0042 0.0106
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0142 0.0361
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0016 0.0069
Brugia malayi jmjC domain containing protein 0.0176 0.1584 0.6747
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0228 0.5314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0016 0.0041
Echinococcus granulosus histone acetyltransferase KAT2B 0.016 0.1439 0.1439
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0016 0.0016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0016 0.0016
Entamoeba histolytica protein kinase, putative 0.106 1 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0333 0.308 0.3073
Echinococcus multilocularis tyrosine protein kinase Abl 0.0172 0.155 0.155
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0336 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0168 0.1508 0.1508
Entamoeba histolytica protein kinase, putative 0.106 1 1
Schistosoma mansoni jumonji domain containing protein 0.0153 0.1371 0.1371
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0106 0.2956
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0016 0.0069
Schistosoma mansoni coup transcription factor 0.0011 0.0016 0.0016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0016 0.0016
Echinococcus granulosus phd:f box containing protein 0.0029 0.0184 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0336 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0106 0.2953
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0184 0.0468
Brugia malayi Pre-SET motif family protein 0.0238 0.2174 0.9259
Echinococcus granulosus c src tyrosine kinase 0.0014 0.0042 0.0042
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0335 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0016 0.0069
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0016 0.0016
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0061 0.0061
Brugia malayi Tyrosine-protein kinase abl-1 0.0172 0.155 0.6601
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0106 0.2953
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0061 0.0261
Schistosoma mansoni cpg binding protein 0.0035 0.0246 0.0246
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0928 0.3952
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0614 0.0614
Schistosoma mansoni bromodomain containing protein 0.0078 0.0653 0.0653
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0083 0.2248
Schistosoma mansoni serine/threonine protein kinase 0.106 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0016 0.0016
Brugia malayi SRC-1 0.0014 0.0042 0.0178
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0233 0.0594
Schistosoma mansoni hypothetical protein 0.0017 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0014 0.0042 0.0042
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0928 0.3952
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0163 0.1459 1
Echinococcus granulosus GPCR family 2 0.0034 0.0233 0.0233
Echinococcus granulosus tyrosine protein kinase Lyn 0.0022 0.0123 0.0123
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.308 1
Loa Loa (eye worm) acetyltransferase 0.0168 0.1508 0.3838
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0606 0.2583
Echinococcus granulosus growth factor receptor bound protein 2 0.0012 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0073 0.0606 0.1543
Brugia malayi MH2 domain containing protein 0.0136 0.1206 0.5135
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0014 0.0042 0.0042
Schistosoma mansoni phd/f-box containing protein 0.0029 0.0184 0.0184
Onchocerca volvulus Alhambra homolog 0.0033 0.0228 0.0857
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0101 0.0101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.308 1
Trypanosoma brucei unspecified product 0.0011 0.0015 0.016
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0336 0.0336
Plasmodium falciparum phd finger protein, putative 0.0033 0.0228 0.6699
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0016 0.0069
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0399 0.7223
Schistosoma mansoni nck2/grb4 0.0012 0.0026 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0336 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0163 0.1459 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0016 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0016 0.0069
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0015 0.0051 0.0041
Schistosoma mansoni tyrosine kinase 0.0014 0.0042 0.0042
Onchocerca volvulus 0.0014 0.005 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0233 0.684
Echinococcus granulosus dna polymerase kappa 0.0045 0.0336 0.0336
Trypanosoma brucei ISWI complex protein 0.0017 0.0078 0.2087
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0176 0.1584 0.1584
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0016 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0083 0.2248
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0107 0.0928 0.2361
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0129 0.6869
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0016 0.0069
Echinococcus multilocularis dnaJ subfamily B 0.0444 0.4133 0.4133
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0333 0.308 0.3073
Echinococcus granulosus zinc finger protein 0.0028 0.0179 0.0179
Brugia malayi jmjC domain containing protein 0.0029 0.0184 0.0783
Echinococcus granulosus lysine specific demethylase 5A 0.0111 0.0969 0.0969
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0106 0.0096
Echinococcus multilocularis activin receptor type 0.001 0.001 0.001
Schistosoma mansoni ap endonuclease 0.002 0.0106 0.0106
Brugia malayi AF-10 protein 0.0011 0.0015 0.0064
Loa Loa (eye worm) hypothetical protein 0.0034 0.0233 0.0594
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.308 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0014 0.0042 0.0042
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0184 0.0184
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0041
Schistosoma mansoni protein kinase 0.001 0.001 0.001
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0233 0.0994
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0242 0.0242
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0549 1
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0016 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0233 0.684
Brugia malayi jmjC domain containing protein 0.0029 0.0184 0.0783
Schistosoma mansoni bromodomain containing protein 0.0011 0.0014 0.0014
Trypanosoma cruzi DNA polymerase eta, putative 0.0016 0.0061 0.1582
Trypanosoma brucei unspecified product 0.0011 0.0015 0.016
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0336 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0168 0.1508 0.1508
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0026 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0041
Brugia malayi PHD-finger family protein 0.0034 0.0237 0.101
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0135 0.0345
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0233 0.0233
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0016 0.0016
Trypanosoma cruzi ISWI complex protein 0.0017 0.0078 0.2087
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0134
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0184 0.5348
Loa Loa (eye worm) hypothetical protein 0.0016 0.0061 0.0156
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0336 0.0772
Echinococcus granulosus activin receptor type 0.001 0.001 0.001
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0336 0.1697
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0026 0.0109
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0399 0.7223
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0016 0.0016
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.0015 0.0101
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0024 0.0135 0.0135
Onchocerca volvulus 0.0035 0.0242 0.0914
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0016 0.0069
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0335 0.0771
Brugia malayi Bromodomain containing protein 0.0048 0.0365 0.1556
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0233 0.0233
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0033 0.0221 0.0221
Onchocerca volvulus 0.0271 0.2486 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0399 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0016 0.0069
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0129 0.367
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.0969 0.0969
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0352 0.0352
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0184 0.5343
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0041
Schistosoma mansoni cpg binding protein 0.0035 0.0246 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0016 0.0041
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0016 0.0069
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0012 0.0026 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0336 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0015 0.0168
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0097 0.0097
Echinococcus granulosus tyrosine protein kinase ABL1 0.0422 0.393 0.393
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0233 0.0233
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0173 0.0173
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.308 1
Schistosoma mansoni hypothetical protein 0.0011 0.0015 0.0015
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0014 0.0042 0.0042
Giardia lamblia Fructose-bisphosphate aldolase 0.0333 0.308 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0111 0.0969 0.0969
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0015 0.0101
Echinococcus multilocularis dual specificity testis specific protein kinase 0.001 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0034 0.0233 0.0592
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.0184 0.0184
Giardia lamblia DINP protein human, muc B family 0.0023 0.0129 0.0079
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0029 0.0184 0.3227
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.308 1
Echinococcus multilocularis phd:f box containing protein 0.0029 0.0184 0.0184
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0015 0.0015
Brugia malayi jmjC domain containing protein 0.0111 0.0969 0.4128
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0106 0.1986
Loa Loa (eye worm) hypothetical protein 0.0033 0.0228 0.058
Brugia malayi PHD-finger family protein 0.0033 0.0228 0.097
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0016 0.0016
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0014 0.0042 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0336 1
Brugia malayi Pre-SET motif family protein 0.0035 0.0242 0.103
Echinococcus granulosus tyrosine protein kinase Src64B 0.0014 0.0042 0.0042
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0106 0.0269
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0014 0.0042 0.0042
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0014 0.0042 0.0042
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0016 0.0016
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0015 0.0039
Echinococcus granulosus tyrosine protein kinase Fyn 0.0014 0.0042 0.0042
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0129 0.0487
Brugia malayi CXXC zinc finger family protein 0.0031 0.0208 0.0887
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0026 0.0308
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0016 0.0016
Trypanosoma brucei unspecified product 0.0037 0.0268 0.7911
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0228 0.0228
Schistosoma mansoni protein phosphatase 2C 0.0029 0.0184 0.0184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0016 0.0016
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0352 0.0352
Brugia malayi Bromodomain containing protein 0.0091 0.078 0.3322
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0016 0.0069
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0061 0.0061
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0336 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0016 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0016 0.0041
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0041
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0336 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0614 0.0614
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.0184 0.0184
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0012 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.016 0.1436 0.3654
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0016 0.0016
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0012 0.0026 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0427 0.0427
Leishmania major hypothetical protein, conserved 0.0029 0.0184 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0106 0.5527
Loa Loa (eye worm) hypothetical protein 0.0011 0.0014 0.0035
Brugia malayi Bromodomain containing protein 0.004 0.0292 0.1243
Loa Loa (eye worm) hypothetical protein 0.005 0.0392 0.0997
Echinococcus multilocularis peregrin 0.004 0.0292 0.0292
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0242 0.0242
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0014 0.0042 0.0042
Echinococcus granulosus cpg binding protein 0.0035 0.0246 0.0246
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0228 0.0228
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0399 0.0987
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0097 0.0097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0552 0.0552
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0083 0.2248
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0106 0.032
Schistosoma mansoni zinc finger protein 0.0028 0.0179 0.0179
Echinococcus multilocularis GPCR, family 2 0.0034 0.0233 0.0233
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0016 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0016 0.0041
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0073 0.0606 0.0606
Leishmania major DNA polymerase kappa, putative 0.0023 0.0129 0.6869
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0016 0.0069
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0233 0.0233
Echinococcus multilocularis cpg binding protein 0.0035 0.0246 0.0246
Schistosoma mansoni tyrosine kinase 0.0014 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0029 0.0184 0.0468
Schistosoma mansoni tyrosine kinase 0.0014 0.0042 0.0042
Giardia lamblia PHD finger protein 15 0.0033 0.0228 0.041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0016 0.0069
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0228 0.4043
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.106 0.9996 0.9996
Leishmania major DNA polymerase eta, putative 0.0016 0.0061 0.296
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.308 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0016 0.0016
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0106 0.0106
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0014 0.0042 0.0042
Schistosoma mansoni tyrosine kinase 0.0014 0.0042 0.0042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0106 0.2953
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0016 0.0069
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0564 0.1436
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.308 1
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.1206 0.3068
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0033 0.0221 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0016 0.0069
Loa Loa (eye worm) hypothetical protein 0.0054 0.0427 0.1086
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0016 0.0041
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.0184 0.0184
Schistosoma mansoni hypothetical protein 0.0034 0.0233 0.0233
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0228 0.0228
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0399 0.0399
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0106 0.0451
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0106 0.0106
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0138 0.0589
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.1206 0.3068
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0029 0.0184 0.5343
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0336 0.1697
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0016 0.0016
Echinococcus granulosus tyrosine protein kinase Fyn 0.0014 0.0042 0.0042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0336 1
Toxoplasma gondii exonuclease III APE 0.002 0.0106 0.1784
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0016 0.0016
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0233 0.0994
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0301 0.0301
Loa Loa (eye worm) jmjC domain-containing protein 0.0111 0.0969 0.2467
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.2174 0.5532
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0173 0.0173
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0184 0.0468
Echinococcus granulosus NCK adaptor protein 0.0012 0.0026 0.0026
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0336 0.0772
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0928 0.2361
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0054 0.0429 0.1093
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.0184 0.0184
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0061 0.0261
Schistosoma mansoni hypothetical protein 0.0034 0.0233 0.0233
Schistosoma mansoni protein kinase 0.001 0.001 0.001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0061 0.0156
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0427 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0336 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0106 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0016 0.0016
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0184 0.0468
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0014 0.0042 0.0042
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0016 0.0016
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0228 0.058
Entamoeba histolytica deoxycytidyl transferase, putative 0.0016 0.0061 0.0052
Echinococcus multilocularis lysine specific demethylase 5A 0.0107 0.0932 0.0932
Echinococcus granulosus tyrosine protein kinase Fyn 0.0014 0.0042 0.0042
Echinococcus multilocularis NCK adaptor protein 0.0012 0.0026 0.0026
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0029 0.0184 0.3227
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0173 0.0173
Brugia malayi jmjC domain containing protein 0.0029 0.0184 0.0783
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0029 0.0184 0.5343
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0336 1
Brugia malayi ecdysteroid receptor 0.0011 0.0016 0.0069
Brugia malayi Sex muscle abnormal protein 5 0.0012 0.0026 0.0109
Brugia malayi nuclear receptor NHR-88 0.0011 0.0016 0.0069
Echinococcus granulosus dual specificity testis-specific protein kinase 0.001 0.001 0.001
Loa Loa (eye worm) TK/ABL protein kinase 0.0422 0.393 1
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0184 0.0184
Plasmodium vivax JmjC domain containing protein 0.0029 0.0184 0.4112
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0015 0.0168
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0016 0.0016
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0081 0.0678 0.1726
Loa Loa (eye worm) hypothetical protein 0.0044 0.0328 0.0834
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0176 0.1584 0.1584
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0336 1
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0016 0.0016
Echinococcus multilocularis growth factor receptor bound protein 2 0.0012 0.0026 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0333 0.308 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0041
Trichomonas vaginalis set domain proteins, putative 0.0271 0.2486 0.8003
Schistosoma mansoni tyrosine kinase 0.0416 0.3872 0.3872
Plasmodium vivax SET domain protein, putative 0.0035 0.0242 0.5697
Schistosoma mansoni growth factor receptor-bound protein 0.0012 0.0026 0.0026
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0184 0.0184
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.0184 0.0184
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0163 0.1459 1
Schistosoma mansoni cpg binding protein 0.0031 0.0208 0.0208
Schistosoma mansoni protein kinase 0.001 0.001 0.001
Brugia malayi nuclear hormone receptor 0.0011 0.0016 0.0069
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0014 0.0042 0.0042
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0016 0.0016
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0301 0.0301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0016 0.0041
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0242 0.0242
Brugia malayi acetyltransferase, GNAT family protein 0.0168 0.1508 0.6424
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0336 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0223 0.0223
Brugia malayi Variant SH3 domain containing protein 0.0012 0.0026 0.0109
Schistosoma mansoni hypothetical protein 0.0034 0.0233 0.0233
Brugia malayi jmjC domain containing protein 0.0029 0.0184 0.0783
Echinococcus granulosus peregrin 0.004 0.0292 0.0292
Trypanosoma cruzi ISWI complex protein 0.0017 0.0078 0.2087
Schistosoma mansoni hypothetical protein 0.0033 0.0228 0.0228
Schistosoma mansoni hypothetical protein 0.0034 0.0233 0.0233
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0422 0.393 0.393
Entamoeba histolytica protein kinase, putative 0.0015 0.0051 0.0041

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 24.88 uM Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay ChEMBL. 24411197

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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