Detailed information for compound 18207

Basic information

Technical information
  • TDR Targets ID: 18207
  • Name: 2-(hydroxymethyl)-5-[4-[(4-nitrophenyl)methyl sulfanyl]pyrazolo[3,4-d]pyrimidin-1-yl]oxolan e-3,4-diol
  • MW: 419.412 | Formula: C17H17N5O6S
  • H donors: 3 H acceptors: 8 LogP: 0.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C1O)O)n1ncc2c1ncnc2SCc1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C17H17N5O6S/c23-6-12-13(24)14(25)17(28-12)21-15-11(5-20-21)16(19-8-18-15)29-7-9-1-3-10(4-2-9)22(26)27/h1-5,8,12-14,17,23-25H,6-7H2
  • InChiKey: NSHWXIMQXLHUQU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(hydroxymethyl)-5-[4-[(4-nitrophenyl)methylsulfanyl]pyrazolo[3,4-d]pyrimidin-1-yl]tetrahydrofuran-3,4-diol
  • 2-(hydroxymethyl)-5-[4-[(4-nitrophenyl)methylthio]-1-pyrazolo[3,4-d]pyrimidinyl]tetrahydrofuran-3,4-diol
  • 2-methylol-5-[4-[(4-nitrobenzyl)thio]pyrazolo[3,4-d]pyrimidin-1-yl]tetrahydrofuran-3,4-diol
  • nitrobenzylthioformycin
  • 2-(hydroxymethyl)-5-[4-[(4-nitrophenyl)methylsulfanyl]pyrazolo[4,5-e]pyrimidin-1-yl]oxolane-3,4-diol
  • 2-(hydroxymethyl)-5-[4-[(4-nitrophenyl)methylsulfanyl]pyrazolo[4,5-e]pyrimidin-1-yl]tetrahydrofuran-3,4-diol
  • 2-(hydroxymethyl)-5-[4-[(4-nitrophenyl)methylthio]-1-pyrazolo[4,5-e]pyrimidinyl]tetrahydrofuran-3,4-diol
  • 2-methylol-5-[4-[(4-nitrobenzyl)thio]pyrazolo[4,5-e]pyrimidin-1-yl]tetrahydrofuran-3,4-diol
  • 64372-71-0
  • NSC269138

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0121 0.0723 0.0797
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0002 0.0002
Echinococcus granulosus nuclear receptor nhr 48 0.0005 0.0002 0.0002
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0041 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1465 0.907 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Schistosoma mansoni hypothetical protein 0.0196 0.1188 0.1309
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0002 0.0002
Echinococcus granulosus protein C ets 2 0.0011 0.0041 0.0045
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.0004 0.0004
Brugia malayi Ets-domain containing protein 0.0076 0.0444 0.049
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0034 0.0034
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0122 0.0134
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.009 0.0099
Brugia malayi Polyprenyl synthetase family protein 0.0411 0.2525 0.2784
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0411 0.2525 0.2784
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0108 0.0082
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0041 0.0045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0074 0.0434 0.0479
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0235 0.0931
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0035 0.0038
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0108 0.0119
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0119
Brugia malayi Inositol-1 0.0042 0.0235 0.0259
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0035 0.0038
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0108 0.0108
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0035 0.0035
Brugia malayi nuclear receptor NHR-88 0.0005 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0108 0.0119
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0344 0.0379
Leishmania major farnesyl pyrophosphate synthase 0.1465 0.907 1
Schistosoma mansoni elf1 0.0011 0.0041 0.0045
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0041 0.0045
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.023 0.0254
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0034 0.0037
Toxoplasma gondii hypothetical protein 0.0056 0.0322 0.0355
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0298 0.0328
Schistosoma mansoni hypothetical protein 0.0042 0.023 0.0254
Loa Loa (eye worm) hypothetical protein 0.0056 0.0318 0.035
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Brugia malayi Ets-domain containing protein 0.0011 0.0041 0.0045
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0277 0.0305
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0208 0.0822
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0108 0.0428
Brugia malayi CXXC zinc finger family protein 0.0029 0.0151 0.0166
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0006
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0108 0.0119
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0035 0.0038
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.023 0.023
Schistosoma mansoni thyroid hormone receptor 0.001 0.0035 0.0038
Entamoeba histolytica recQ family helicase, putative 0.0005 0.0003 0.001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0434 0.0479
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0052 0.0057
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0411 0.2525 0.2784
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0005 0.0006
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0411 0.2525 0.2525
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0052 0.0057
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0041 0.0045
Loa Loa (eye worm) fli-1 protein 0.0231 0.1405 0.1549
Schistosoma mansoni inositol monophosphatase 0.0042 0.0235 0.0259
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0006
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0002 0.0002
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0108 0.0119
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0005 0.0006
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0034 0.0037
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1465 0.907 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0034 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0035 0.0038
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0052 0.0206
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0411 0.2525 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0434 0.0479
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1465 0.907 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0235 0.0259
Brugia malayi ecdysteroid receptor 0.001 0.0035 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0017 0.0018
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0022 0.0108 0.0428
Schistosoma mansoni ets-related 0.0231 0.1405 0.1549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0298 0.0328
Echinococcus granulosus bloom syndrome protein 0.0024 0.0122 0.0134
Leishmania major solanesyl-diphosphate synthase, putative 0.0411 0.2525 0.2784
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0411 0.2525 0.2784
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0002 0.0042
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0017 0.0018
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0108 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0235 0.0259
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0235 0.0259
Loa Loa (eye worm) hypothetical protein 0.0074 0.0434 0.0479
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0122 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0035 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0035 0.0038
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0035 0.0799
Schistosoma mansoni gabp alpha 0.0076 0.0444 0.049
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0108 0.0119
Echinococcus multilocularis cpg binding protein 0.003 0.0161 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0434 0.0479
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0299 0.0329
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.0913
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0434 0.0479
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0434 0.0479
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0002 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0035 0.0038
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0041 0.0041
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0041 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0298 0.0328
Brugia malayi tailless protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0035 0.0038
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0411 0.2525 1
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0411 0.2525 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Echinococcus granulosus FTZ F1 alpha 0.001 0.0035 0.0038
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0035 0.0038
Onchocerca volvulus 0.0005 0.0002 0.0042
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0411 0.2525 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0997 0.11
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0022 0.0108 0.0428
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0035 0.0038
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1465 0.907 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0045
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0108 0.0119
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0411 0.2525 0.2784
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0411 0.2525 0.2784
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0108 0.0119
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0277 0.0305
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0108 0.0119
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0434 0.172
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0318 0.035
Brugia malayi ecdysone receptor 0.0005 0.0002 0.0002
Schistosoma mansoni DNA helicase recq5 0.001 0.0034 0.0037
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.0913
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0444 0.049
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0411 0.2525 0.2784
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0035 0.0799
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0108 0.0119
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0349 0.2138 0.2358
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0434 0.172
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0108 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0035 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0005 0.0002 0.0002
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0235 0.0259
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0298 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0006
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0002 0.0002
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0034 0.0037
Echinococcus multilocularis protein C ets 2 0.0011 0.0041 0.0041
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0108 0.0119
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0298 0.0298
Echinococcus multilocularis ets variant gene 4 0.0011 0.0041 0.0041
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0073 0.0078
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0235 0.0259
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0006
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0108 0.0119
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0028 0.003
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0108 0.0119
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0434 0.0479
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0045
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0108 0.0119
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0411 0.2525 0.2782
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0997 0.11
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Onchocerca volvulus 0.0029 0.0151 0.3472
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.0913
Schistosoma mansoni zinc finger protein 0.0005 0.0002 0.0002
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0041 0.0045
Brugia malayi nuclear receptor NHR-67 0.0005 0.0002 0.0002
Echinococcus granulosus cpg binding protein 0.003 0.0161 0.0177
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0035 0.0035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0299 0.0329
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0411 0.2525 1
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0235 0.0235
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0014
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0298 0.0328
Brugia malayi steroid hormone receptor 0.001 0.0035 0.0038
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0041 0.0045
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0035 0.0038
Onchocerca volvulus 0.0005 0.0002 0.0042
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0108 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.0056 0.0318 0.035
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0034 0.0037
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0349 0.2138 0.2358
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Brugia malayi Muscleblind-like protein 0.032 0.1962 0.2164
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0005 0.0004 0.0004
Loa Loa (eye worm) inositol-1 0.0042 0.0235 0.0259
Trichomonas vaginalis helicase, putative 0.0007 0.0013 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0108 0.0119
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0041 0.0045
Trypanosoma cruzi polyprenyl synthase, putative 0.0582 0.3585 0.3952
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0035 0.0038
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1465 0.907 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0318 0.0347
Echinococcus multilocularis muscleblind protein 0.032 0.1962 0.1962
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0299 0.0329
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0035 0.0038
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0108 0.0119
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0005 0.0006
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0108 0.0119
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0041 0.0041
Schistosoma mansoni trans-prenyltransferase 0.0411 0.2525 0.2784
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0411 0.2525 0.2784
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0108 0.0119
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0002 0.0002
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0434 0.172
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0027 0.003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0028 0.003
Echinococcus granulosus thyroid hormone receptor alpha 0.0005 0.0002 0.0002
Schistosoma mansoni nuclear receptor 0.0005 0.0002 0.0002
Trypanosoma cruzi polyprenyl synthase, putative 0.0582 0.3585 0.3952
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0034 0.0037
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0052 0.0057
Brugia malayi transcription factor E74 isoform 0.0011 0.0041 0.0045
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0034 0.0037
Loa Loa (eye worm) hypothetical protein 0.0056 0.0318 0.035
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0002 0.0002
Echinococcus multilocularis nuclear receptor nhr 48 0.0005 0.0002 0.0002
Brugia malayi nuclear hormone receptor 0.001 0.0035 0.0038
Schistosoma mansoni hypothetical protein 0.0196 0.1188 0.1309
Loa Loa (eye worm) hypothetical protein 0.0056 0.0318 0.035
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0411 0.2525 1
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0108 0.0119
Echinococcus granulosus muscleblind protein 0.032 0.1962 0.2164
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0035 0.0038
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0108 0.0119
Entamoeba histolytica hypothetical protein 0.0042 0.023 0.0913
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0411 0.2525 0.2784
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1465 0.907 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0298 0.0328
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0108 0.0119
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0108 0.0119
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0041 0.0045
Onchocerca volvulus 0.0022 0.0108 0.2488
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0582 0.3585 0.3585
Brugia malayi Polyprenyl synthetase family protein 0.1465 0.907 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) DR-78 0.0005 0.0002 0.0002
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0034 0.0034
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0108 0.0119
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0582 0.3585 0.3952
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0014
Schistosoma mansoni cpg binding protein 0.003 0.0161 0.0177
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0108 0.0119
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0074 0.0434 0.0479
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0411 0.2525 0.2784
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0035 0.0038
Leishmania major mitochondrial DNA polymerase beta 0.0349 0.2138 0.2358
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0017 0.0018
Brugia malayi nuclear receptor NHR-88 0.001 0.0035 0.0038
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0034 0.0037
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0108 0.0116
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0122 0.0134
Brugia malayi Ets-domain containing protein 0.0076 0.0444 0.049
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0041 0.0045
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.023 0.0254
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0041 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0434 0.0479
Treponema pallidum octaprenyl-diphosphate synthase 0.0582 0.3585 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0108 0.0119
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0103 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0035 0.0038
Schistosoma mansoni ets-related 0.0011 0.0041 0.0045
Schistosoma mansoni DNA helicase recq1 0.001 0.0034 0.0037
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0411 0.2525 0.2784
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0235 0.0259
Onchocerca volvulus 0.0022 0.0108 0.2488
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0005 0.0006
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1465 0.907 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0444 0.049
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0002 0.0002
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0235 0.0259
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0002 0.0002
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1465 0.907 0.907
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0035 0.0035
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0411 0.2525 1
Loa Loa (eye worm) polyprenyl synthetase 0.0411 0.2525 0.2784
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.0997 0.11
Leishmania major polyprenyl synthase, putative 0.0582 0.3585 0.3952
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0108 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0034 0.0037
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0005 0.0006
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0002 0.0002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0035 0.0038
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0108 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0035 0.0038
Brugia malayi hypothetical protein 0.0005 0.0005 0.0006
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0035 0.0038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0035 0.0038
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0002 0.0002
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0035 0.0799
Schistosoma mansoni blooms syndrome DNA helicase 0.0005 0.0004 0.0004
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0411 0.2525 0.2525
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0035 0.0038
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0002 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0351 0.0387
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0035 0.0038
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0005 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0299 0.0329
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1465 0.907 1
Schistosoma mansoni nuclear receptor 0.0005 0.0002 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0434 0.0479
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0089 0.0098
Onchocerca volvulus 0.0074 0.0434 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0235 0.0259
Echinococcus multilocularis muscleblind protein 1 0.032 0.1962 0.1962
Brugia malayi hypothetical protein 0.0005 0.0005 0.0006
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0004 0.0015
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1465 0.907 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0072 0.0079
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0002 0.0002
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0277 0.0305
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0035 0.0035
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0035 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0434 0.0479
Schistosoma mansoni nuclear hormone receptor 0.001 0.0035 0.0038
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0017 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0434 0.0479
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1465 0.907 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0002 0.0002
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0035 0.0038
Mycobacterium ulcerans hypothetical protein 0.0184 0.1113 0.1227
Echinococcus multilocularis geminin 0.0196 0.1188 0.1188
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0041 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0041 0.0045
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0208 0.0229
Schistosoma mansoni inositol monophosphatase 0.0042 0.0235 0.0259
Mycobacterium ulcerans hypothetical protein 0.0074 0.0434 0.0479
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0002 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0434 0.0479
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1465 0.907 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0108 0.0119
Brugia malayi nuclear hormone receptor 0.0005 0.0002 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0035 0.0035
Onchocerca volvulus 0.0022 0.0108 0.2488
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0041 0.0041
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0035 0.0038
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0035 0.0035
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0411 0.2525 0.2784
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0434 0.0479
Echinococcus granulosus geminin 0.0196 0.1188 0.1309
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0014
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0582 0.3585 0.3952
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0035 0.0038
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0108 0.0119
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0108 0.0119
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0277 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0298 0.0328
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1465 0.907 1
Onchocerca volvulus 0.001 0.0035 0.0799
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0052 0.0057
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.0006
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0108 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0035 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.0014
Brugia malayi nuclear receptor RXR 0.0005 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.032 0.1962 0.2164
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0035 0.0038
Brugia malayi conserved hypotetical protein 0.0005 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0065 0.0376 0.0414
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0108 0.0428
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0005 0.0004 0.0004
Schistosoma mansoni coup transcription factor 0.001 0.0035 0.0038
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0035 0.0038
Brugia malayi nuclear receptor RXR 0.0005 0.0002 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0434 0.0479
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0035 0.0038
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0108 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0035 0.0038
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0108 0.0119
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0318 0.0314
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1465 0.907 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0013 0.0014
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0108 0.0119
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0035 0.0038
Schistosoma mansoni cpg binding protein 0.003 0.0161 0.0177
Onchocerca volvulus 0.0022 0.0108 0.2488
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0108 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0014
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0434 0.172
Schistosoma mansoni hypothetical protein 0.0011 0.0041 0.0045
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0434 0.172
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0235 0.0259
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0005 0.0002 0.0002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0318 0.035
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0434 0.0479
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0035 0.0038
Schistosoma mansoni hypothetical protein 0.0011 0.0041 0.0045
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0108 0.0119
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1465 0.907 1
Loa Loa (eye worm) polyprenyl synthetase 0.1465 0.907 1
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0411 0.2525 0.2784
Mycobacterium tuberculosis Conserved hypothetical protein 0.0184 0.1113 0.1227
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0298 0.0328
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0434 0.0479
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0041 0.0041
Giardia lamblia Farnesyl diphosphate synthase 0.1465 0.907 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0108 0.0119
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0582 0.3585 0.3952
Schistosoma mansoni ets 0.0011 0.0041 0.0045
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0151 0.0166
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.031 0.0342
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0017 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.0014
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0411 0.2525 0.2757
Loa Loa (eye worm) hypothetical protein 0.032 0.1962 0.2164
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0318 0.1257
Loa Loa (eye worm) hypothetical protein 0.0056 0.0318 0.035
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0035 0.0038
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0108 0.0119
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0108 0.0119
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0028 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0108 0.0119
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0035 0.0038
Brugia malayi hypothetical protein 0.0005 0.0002 0.0002
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0002 0.0002
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0035 0.0038
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0108 0.0119
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0041 0.0045
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0582 0.3585 0.3952
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0444 0.0444
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0108 0.0119
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0035 0.0038
Schistosoma mansoni cpg binding protein 0.0029 0.0151 0.0166
Loa Loa (eye worm) oxidoreductase 0.0022 0.0108 0.0119
Schistosoma mansoni thyroid hormone receptor 0.001 0.0035 0.0038
Brugia malayi Fli-1 protein 0.0231 0.1405 0.1549
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0038
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0235 0.0259
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0108 0.0119
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0349 0.2138 0.2358
Loa Loa (eye worm) RecQ helicase 0.0024 0.0122 0.0134
Brugia malayi hypothetical protein 0.0042 0.023 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0035 0.0038
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0002 0.0002
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0108 0.0119
Schistosoma mansoni glutathione synthetase 0.0411 0.2525 0.2784

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) ~ 0.001 M In vitro inhibition of growth of L1210 mouse leukemic cells ChEMBL. 7328577
ILS (functional) = 1 % Increase in life span of tumor L1210 leukemic mice 1-5 days after 200 mg/kg of the compound administered ChEMBL. 7328577
Toxicity (functional) 0 In vitro cytotoxicity of the compound against L1210 leukemic cells 1-5 days after administration of 200 mg/kg of the compound; Yes ChEMBL. 7328577

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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