Detailed information for compound 1827469

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 216.236 | Formula: C12H12N2O2
  • H donors: 1 H acceptors: 2 LogP: 1.11 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)NCc1ccc(cc1)c1ocnc1
  • InChi: 1S/C12H12N2O2/c1-9(15)14-6-10-2-4-11(5-3-10)12-7-13-8-16-12/h2-5,7-8H,6H2,1H3,(H,14,15)
  • InChiKey: QIVURCIUAPRKEQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0253 0.0236
Mycobacterium tuberculosis Conserved protein 0.0041 0.0188 0.0373
Loa Loa (eye worm) hypothetical protein 0.0041 0.0188 0.0676
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0189 0.2328
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0309
Schistosoma mansoni hypothetical protein 0.0048 0.024 0.0223
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0155
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0094 0.034
Leishmania major hypothetical protein, conserved 0.0041 0.0188 0.2312
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0309
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0125 0.0804 1
Echinococcus granulosus intermediate filament protein 0.009 0.0549 0.0533
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.005 0.0598
Brugia malayi cytoplasmic intermediate filament protein 0.0048 0.0244 0.088
Mycobacterium ulcerans lipase LipD 0.0041 0.0188 0.0318
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0088 0.0071
Echinococcus granulosus lamin 0.009 0.0549 0.0533
Toxoplasma gondii NAC domain-containing protein 0.0039 0.0179 0.066
Trypanosoma brucei RNA helicase, putative 0.0233 0.1594 1
Schistosoma mansoni caspase-7 (C14 family) 0.0067 0.0383 0.0367
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0188 0.2312
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0189 0.2328
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0183 0.1231 0.4441
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0189 0.2328
Mycobacterium ulcerans beta-lactamase 0.0041 0.0188 0.0318
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0026 0.0081 0.0064
Schistosoma mansoni hypothetical protein 0.0018 0.0021 0.0004
Trichomonas vaginalis esterase, putative 0.0041 0.0188 0.2312
Schistosoma mansoni hypothetical protein 0.0018 0.0021 0.0004
Schistosoma mansoni hypothetical protein 0.0048 0.024 0.0223
Echinococcus granulosus sodium:myo inositol cotransporter 0.1384 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0094 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0111 0.1363
Loa Loa (eye worm) hypothetical protein 0.0033 0.0135 0.0487
Echinococcus multilocularis dna polymerase eta 0.0022 0.005 0.0033
Leishmania major importin beta-1 subunit, putative 0.0026 0.0084 0.1017
Trypanosoma brucei protein kinase, putative 0.0057 0.031 0.1943
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0172 0.0619
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0129 0.0801
Brugia malayi RNA, U transporter 1 0.0092 0.0566 0.204
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.0179 0.0354
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0189 0.2328
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0353 0.2471 0.2458
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0309
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0088 0.0071
Loa Loa (eye worm) Smad1 0.0027 0.0088 0.0316
Brugia malayi Cell death protein 3 precursor 0.0067 0.0383 0.1382
Schistosoma mansoni smad1 5 8 and 0.0027 0.0088 0.0071
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0314 0.0651
Brugia malayi MH2 domain containing protein 0.0027 0.0088 0.0316
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.005 0.0598
Echinococcus multilocularis Niemann Pick C1 protein 0.0115 0.0734 0.0718
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0094 0.0113
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0094 0.1149
Loa Loa (eye worm) hypothetical protein 0.0032 0.0129 0.0464
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.005 0.0309
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0226 0.2789
Echinococcus multilocularis ubiquitin specific protease 41 0.0125 0.0804 0.0788
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.005 0.0033
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.005 0.0072
Onchocerca volvulus 0.0106 0.0666 0.269
Echinococcus multilocularis geminin 0.0942 0.6767 0.6762
Schistosoma mansoni Smad4 0.0027 0.0088 0.0071
Echinococcus multilocularis high affinity choline transporter 1 0.0353 0.2471 0.2458
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0188 0.2312
Mycobacterium tuberculosis Conserved protein 0.0041 0.0188 0.0373
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0446 0.5533
Schistosoma mansoni hypothetical protein 0.0233 0.1594 0.1579
Onchocerca volvulus 0.0165 0.1093 0.442
Loa Loa (eye worm) intermediate filament protein 0.009 0.0549 0.1982
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0094 0.0169
Plasmodium falciparum importin beta, putative 0.0032 0.0129 0.0244
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0353 0.2471 1
Leishmania major basic transcription factor 3a, putative 0.0039 0.0179 0.2206
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0084 0.1017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0188 0.0676
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0088 0.0071
Toxoplasma gondii LsmAD domain-containing protein 0.0058 0.0314 0.1211
Onchocerca volvulus 0.0028 0.0094 0.0373
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0188 0.0373
Loa Loa (eye worm) hypothetical protein 0.0022 0.005 0.0181
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0043 0.0205 0.2532
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0309
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.005 0.0598
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.0038
Echinococcus granulosus smad 0.0027 0.0088 0.0071
Loa Loa (eye worm) hypothetical protein 0.0056 0.0301 0.1087
Loa Loa (eye worm) ICD-1 protein 0.0039 0.0179 0.0645
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0021 0.0004
Brugia malayi hypothetical protein 0.0067 0.0383 0.1382
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0883 0.6342 0.6335
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0094 0.0113
Brugia malayi intermediate filament protein 0.009 0.0549 0.1982
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0125 0.0804 1
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0043 0.0205 0.0188
Onchocerca volvulus Cell death protein 3 homolog 0.0067 0.0383 0.1543
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.0038
Brugia malayi beta-lactamase family protein 0.0041 0.0188 0.0676
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.031 0.3846
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.031 0.1943
Entamoeba histolytica hypothetical protein 0.0039 0.0179 0.2206
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.031 0.0294
Loa Loa (eye worm) hypothetical protein 0.0088 0.0537 0.1938
Brugia malayi MH1 domain containing protein 0.0027 0.0088 0.0316
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.005 0.0309
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0255 0.0239
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.005 0.0016
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0253 0.0236
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0255 0.0921
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0017 0.0102
Onchocerca volvulus 0.0041 0.0188 0.0751
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0002 0.0008
Echinococcus multilocularis musashi 0.009 0.0549 0.0533
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.005 0.0181
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0188 0.0171
Echinococcus multilocularis expressed conserved protein 0.0108 0.0682 0.0666
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0043 0.0057
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0188 0.0171
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.031 0.3846
Schistosoma mansoni DNA polymerase eta 0.0022 0.005 0.0033
Brugia malayi MAP kinase sur-1 0.0057 0.031 0.112
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0188 0.1172
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0094 0.0113
Schistosoma mansoni hypothetical protein 0.0347 0.2423 0.241
Brugia malayi beta-lactamase 0.0041 0.0188 0.0676
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.031 0.112
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0021 0.0004
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0189 0.2328
Schistosoma mansoni apoptosis regulator bax 0.0093 0.0572 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0179 0.2206
Echinococcus granulosus lysosomal alpha glucosidase 0.0183 0.1231 0.1216
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0255 0.0921
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0125 0.0804 0.504
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0255 0.0239
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.0038
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0017 0.0187
Echinococcus granulosus expressed conserved protein 0.0108 0.0682 0.0666
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.031 0.3846
Schistosoma mansoni transcription factor btf3 0.0039 0.0179 0.0162
Echinococcus granulosus chromobox protein 1 0.0076 0.0446 0.0429
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0179 0.2206
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.005 0.0033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.005 0.0598
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0189 0.2328
Schistosoma mansoni inositol transporter 0.1384 1 1
Echinococcus multilocularis caspase 2 0.0067 0.0383 0.0367
Leishmania major DNA polymerase eta, putative 0.0022 0.005 0.0598
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0179 0.2206
Echinococcus granulosus sodium:glucose cotransporter 2 0.1384 1 1
Echinococcus multilocularis snurportin 1 0.0347 0.2423 0.241
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.1231 0.1216
Schistosoma mansoni high-affinity choline transporter 0.0353 0.2471 0.2458
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0093 0.0572 0.0556
Loa Loa (eye worm) hypothetical protein 0.0041 0.0188 0.0676
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0189 0.0699
Onchocerca volvulus 0.009 0.0549 0.2217
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0255 0.0239
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0088 0.0316
Schistosoma mansoni lamin 0.009 0.0549 0.0533
Brugia malayi MH2 domain containing protein 0.0395 0.2772 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0155
Echinococcus granulosus transcription factor btf3 0.0039 0.0179 0.0162
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0643 0.4584 1
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0043 0.0205 0.074
Echinococcus multilocularis chromobox protein 1 0.0076 0.0446 0.0429
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.005 0.0598
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0094 0.1149
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0043 0.0205 0.0412
Plasmodium vivax ataxin-2 like protein, putative 0.0058 0.0314 0.0651
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0253 0.0912
Loa Loa (eye worm) hypothetical protein 0.0041 0.0188 0.0676
Echinococcus granulosus high affinity choline transporter 1 0.0353 0.2471 0.2458
Loa Loa (eye worm) hypothetical protein 0.0043 0.0209 0.0754
Echinococcus multilocularis dna polymerase kappa 0.0022 0.005 0.0033
Entamoeba histolytica transcription factor BTF3, putative 0.0039 0.0179 0.2206
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0188 0.0373
Schistosoma mansoni hypothetical protein 0.0093 0.0572 0.0556
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.005 0.0598
Schistosoma mansoni hypothetical protein 0.0018 0.0021 0.0004
Schistosoma mansoni sodium/solute symporter 0.0353 0.2471 0.2458
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0125 0.0804 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0188 0.0171
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0301 0.1087
Loa Loa (eye worm) hypothetical protein 0.0042 0.0197 0.071
Onchocerca volvulus Huntingtin homolog 0.0133 0.0866 0.3499
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0309
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0094 0.1149
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.0179 0.1118
Echinococcus multilocularis chromobox protein 1 0.0076 0.0446 0.0429
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0043 0.0205 0.074
Treponema pallidum hypothetical protein 0.0643 0.4584 0.5
Echinococcus multilocularis protein patched 0.0049 0.0253 0.0236
Echinococcus granulosus Niemann Pick C1 protein 0.0165 0.1095 0.108
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0189 0.2328
Brugia malayi MH2 domain containing protein 0.0027 0.0088 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0111 0.1363
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.031 0.0294
Loa Loa (eye worm) hypothetical protein 0.0028 0.0094 0.034
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0017 0.0062
Brugia malayi CHE-14 protein 0.0049 0.0253 0.0912
Schistosoma mansoni patched 1 0.0049 0.0253 0.0236
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0021 0.0076
Schistosoma mansoni hypothetical protein 0.0048 0.024 0.0223
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0155
Schistosoma mansoni hypothetical protein 0.0067 0.0383 0.0367
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.031 0.0294
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0094 0.034
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0093 0.0572 0.0556
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0017 0.0062
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.005 0.0072
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.005 0.0309
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0189 0.2328
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0129 0.0801
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0026 0.0081 0.0064
Schistosoma mansoni hypothetical protein 0.0018 0.0021 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0094 0.0169
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0226 0.0905
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0189 0.2328
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0017 0.0187
Loa Loa (eye worm) hypothetical protein 0.0353 0.2471 0.8912
Brugia malayi Heterochromatin protein 1 0.0076 0.0446 0.1607
Brugia malayi hypothetical protein 0.0037 0.0164 0.0593
Loa Loa (eye worm) hypothetical protein 0.0353 0.2471 0.8912
Echinococcus granulosus Smad4 0.0027 0.0088 0.0071
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0188 0.2312
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0094 0.1149
Leishmania major DNA polymerase kappa, putative 0.0022 0.005 0.0598
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0189 0.0172
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0084 0.1017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0199 0.0182
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0314 0.3894
Brugia malayi GH02984p 0.0353 0.2471 0.8912
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0309
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0043 0.0205 0.2532
Loa Loa (eye worm) apoptosis regulator protein 0.0093 0.0572 0.2065
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.0179 0.0354
Plasmodium vivax importin-beta 2, putative 0.0032 0.0129 0.0244
Echinococcus granulosus dna polymerase kappa 0.0022 0.005 0.0033
Brugia malayi beta-NAC-like protein 0.0039 0.0179 0.0645
Schistosoma mansoni alpha-glucosidase 0.0158 0.1045 0.1029
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0188 0.0373
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0094 0.0113
Echinococcus multilocularis sodium:glucose cotransporter 2 0.1384 1 1
Echinococcus multilocularis GPCR, family 2 0.0018 0.0021 0.0004
Loa Loa (eye worm) hypothetical protein 0.009 0.0549 0.1982
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0088 0.0316
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0125 0.0804 1
Echinococcus multilocularis transcription factor btf3 0.0039 0.0179 0.0162
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0043 0.0057
Trypanosoma brucei unspecified product 0.0022 0.005 0.0309
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0094 0.0113
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0189 0.2328
Entamoeba histolytica hypothetical protein 0.0042 0.0199 0.2458
Loa Loa (eye worm) hypothetical protein 0.0061 0.0334 0.1205
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0188 0.2312
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0125 0.0804 1
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0643 0.4584 1
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0043 0.0205 0.0188
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0043 0.0205 0.074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0255 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0309
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0084 0.1017
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0117 0.0747 0.0731
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0189 0.2328
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0125 0.0804 0.0788
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0043 0.0057
Brugia malayi Smad1 0.0027 0.0088 0.0316
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.031 0.0294
Brugia malayi hypothetical protein 0.0165 0.1093 0.3944
Loa Loa (eye worm) hypothetical protein 0.0041 0.0188 0.0676
Echinococcus multilocularis apoptotic protease activating factor 1 0.0067 0.0383 0.0367
Echinococcus multilocularis solute carrier family 5 0.1384 1 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0572 0.2065
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0309
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0189 0.2328
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.031 0.3846
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0179 0.2206
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0188 0.2312
Echinococcus granulosus importin subunit beta 1 0.0032 0.0129 0.0112
Brugia malayi hypothetical protein 0.0133 0.0866 0.3123
Entamoeba histolytica hypothetical protein 0.0042 0.0199 0.2458
Schistosoma mansoni hypothetical protein 0.0942 0.6767 0.6762
Schistosoma mansoni hypothetical protein 0.0053 0.028 0.0263
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0043 0.0205 0.2532
Echinococcus multilocularis Smad4 0.0027 0.0088 0.0071
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.031 0.3846
Schistosoma mansoni hypothetical protein 0.0038 0.0172 0.0155
Loa Loa (eye worm) hypothetical protein 0.0042 0.0197 0.071
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0253 0.0236
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0043 0.0205 0.0188
Echinococcus multilocularis lamin dm0 0.009 0.0549 0.0533
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0188 0.0318
Loa Loa (eye worm) hypothetical protein 0.0038 0.0172 0.0619
Trypanosoma cruzi PAB1-binding protein , putative 0.0058 0.0314 0.3894
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0188 0.2312
Brugia malayi MH1 domain containing protein 0.0027 0.0088 0.0316
Echinococcus granulosus ubiquitin specific protease 41 0.0125 0.0804 0.0788
Loa Loa (eye worm) MH2 domain-containing protein 0.0395 0.2772 1
Onchocerca volvulus Huntingtin homolog 0.0133 0.0866 0.3499
Loa Loa (eye worm) hypothetical protein 0.0067 0.0383 0.1382
Loa Loa (eye worm) hypothetical protein 0.0058 0.0314 0.1134
Brugia malayi chromobox protein homolog 3 0.0043 0.0202 0.0729
Echinococcus granulosus solute carrier family 5 0.1384 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0301 0.1087
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0347 0.2423 0.8738
Mycobacterium leprae Probable lipase LipE 0.0041 0.0188 0.0208
Echinococcus granulosus snurportin 1 0.0347 0.2423 0.241
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.005 0.0033
Echinococcus granulosus geminin 0.0942 0.6767 0.6762
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.005 0.0181
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0188 0.0373
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0115 0.0734 0.9125
Brugia malayi hypothetical protein 0.0042 0.0199 0.0718
Brugia malayi Importin beta-1 subunit 0.0032 0.0129 0.0464
Onchocerca volvulus 0.0041 0.0188 0.0751
Loa Loa (eye worm) hypothetical protein 0.0133 0.0866 0.3123
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.031 0.1195
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0093 0.0572 0.0556
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.1231 0.1216
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.005 0.0598
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0202 0.2494
Echinococcus granulosus lamin dm0 0.009 0.0549 0.0533
Brugia malayi isocitrate dehydrogenase 0.0017 0.0017 0.0062
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0002 0.0008
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.009 0.0549 0.1982
Toxoplasma gondii ABC1 family protein 0.0041 0.0188 0.0694
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.031 0.3846
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0188 0.2312
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0643 0.4584 1
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.031 0.0294
Echinococcus multilocularis smad 0.0027 0.0088 0.0071
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0446 0.5533
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0125 0.0804 0.2899
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0043 0.0205 0.074
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0125 0.0804 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0199 0.0182
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0043 0.0209 0.0192
Echinococcus multilocularis protein dispatched 1 0.0056 0.0304 0.0287
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0179 0.2206
Schistosoma mansoni smad1 5 8 and 0.0027 0.0088 0.0071
Brugia malayi Intermediate filament tail domain containing protein 0.009 0.0549 0.1982
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0188 0.0676
Entamoeba histolytica hypothetical protein 0.0042 0.0199 0.2458
Echinococcus multilocularis lamin 0.009 0.0549 0.0533
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0043 0.5
Schistosoma mansoni smad1 5 8 and 0.0027 0.0088 0.0071
Trypanosoma brucei glucosidase, putative 0.0041 0.0189 0.1179
Loa Loa (eye worm) hypothetical protein 0.0067 0.0383 0.1382
Loa Loa (eye worm) hypothetical protein 0.0028 0.0094 0.034
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0043 0.0205 0.2532
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0125 0.0804 0.0788
Echinococcus granulosus dna polymerase eta 0.0022 0.005 0.0033
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0188 0.0318
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0301 0.1087
Echinococcus multilocularis Niemann Pick C1 protein 0.0165 0.1095 0.108
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0188 0.0373
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.031 0.3846
Schistosoma mansoni hypothetical protein 0.0942 0.6767 0.6762
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0093 0.0572 0.0556
Loa Loa (eye worm) transcription factor SMAD2 0.0395 0.2772 1
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0043 0.0205 0.2532
Loa Loa (eye worm) hypothetical protein 0.0115 0.0734 0.2646
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0035 0.0038
Brugia malayi beta-lactamase family protein 0.0041 0.0188 0.0676
Echinococcus granulosus Niemann Pick C1 protein 0.0115 0.0734 0.0718
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0133 0.0866 0.3123
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0088 0.0071
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0043 0.0205 0.1282
Brugia malayi Sodium:solute symporter family protein 0.0353 0.2471 0.8912
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0189 0.0681
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0226 0.2789
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0008
Schistosoma mansoni importin beta-1 0.0032 0.0129 0.0112
Schistosoma mansoni chromobox protein 0.0076 0.0446 0.0429
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.005 0.0598
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0021 0.0076
Trypanosoma brucei PAB1-binding protein , putative 0.0058 0.0314 0.1968
Plasmodium falciparum ataxin-2 like protein, putative 0.0058 0.0314 0.0651
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0253 0.3127
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0643 0.4584 1
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0129 0.0454
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0155
Echinococcus granulosus caspase 2 0.0067 0.0383 0.0367
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0188 0.0373
Echinococcus granulosus apoptotic protease activating factor 1 0.0067 0.0383 0.0367
Brugia malayi hypothetical protein 0.0058 0.0314 0.1134
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0188 0.0171
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0084 0.1017
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.005 0.0309
Onchocerca volvulus 0.0041 0.0188 0.0751
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0188 0.0373
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0017 0.0102
Schistosoma mansoni smad 0.0027 0.0088 0.0071
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.031 0.3454
Leishmania major hypothetical protein, conserved 0.0058 0.0314 0.3894
Schistosoma mansoni hypothetical protein 0.0042 0.0199 0.0182
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0021 0.0004
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.031 0.3846
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.005 0.0181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0255 0.0239
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0202 0.081
Brugia malayi Niemann-Pick C1 protein precursor 0.0115 0.0734 0.2646
Schistosoma mansoni inositol transporter 0.1384 1 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0125 0.0804 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0088 0.0071
Onchocerca volvulus 0.0033 0.0135 0.0538
Echinococcus multilocularis sodium:myo inositol cotransporter 0.1384 1 1
Schistosoma mansoni alpha glucosidase 0.0041 0.0189 0.0172
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0017 0.0187
Schistosoma mansoni alpha-glucosidase 0.0158 0.1045 0.1029
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0643 0.4584 1
Onchocerca volvulus 0.0353 0.2471 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.005 0.0033
Schistosoma mansoni intermediate filament proteins 0.009 0.0549 0.0533
Loa Loa (eye worm) hypothetical protein 0.0125 0.0804 0.2899
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0021 0.0004
Schistosoma mansoni hypothetical protein 0.0048 0.024 0.0223
Loa Loa (eye worm) beta-lactamase 0.0041 0.0188 0.0676
Schistosoma mansoni hypothetical protein 0.0026 0.0081 0.0064
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0094 0.034
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0259 0.1783 0.3866
Onchocerca volvulus 0.009 0.0549 0.2217
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0043 0.0205 0.0412
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0255 0.0239
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.005 0.0309
Onchocerca volvulus 0.0067 0.0383 0.1543
Schistosoma mansoni chromobox protein 0.0076 0.0446 0.0429
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0188 0.0208
Loa Loa (eye worm) hypothetical protein 0.0043 0.0202 0.0729
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0043 0.0205 0.2532
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0021 0.0076
Mycobacterium tuberculosis Conserved protein 0.0041 0.0188 0.0373
Loa Loa (eye worm) hypothetical protein 0.0028 0.0094 0.034
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0129 0.0112
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0093 0.0572 0.2065
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.031 0.3846
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.031 0.3846
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0202 0.2494
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0125 0.0804 0.0788
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0189 0.2328
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0804 1
Schistosoma mansoni lamin 0.009 0.0549 0.0533
Schistosoma mansoni hypothetical protein 0.0093 0.0572 0.0556
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0125 0.0804 0.0788
Brugia malayi Glycosyl hydrolases family 31 protein 0.0183 0.1231 0.4441
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0261 0.1796 0.6478
Brugia malayi follicle stimulating hormone receptor 0.0261 0.1796 0.6478
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0188 0.0373
Loa Loa (eye worm) hypothetical protein 0.0049 0.0253 0.0912
Loa Loa (eye worm) hypothetical protein 0.0165 0.1093 0.3944
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0048 0.0244 0.088
Schistosoma mansoni hypothetical protein 0.0093 0.0572 0.0556
Echinococcus granulosus GPCR family 2 0.0018 0.0021 0.0004
Mycobacterium ulcerans hypothetical protein 0.0028 0.0094 0.0113
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0043 0.0205 0.0766
Loa Loa (eye worm) hypothetical protein 0.0041 0.0188 0.0676
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0255 0.0239
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0353 0.2471 0.2458
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0189 0.2328
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0189 0.0681
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0094 0.1149
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0189 0.0172
Loa Loa (eye worm) hypothetical protein 0.0041 0.0188 0.0676
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0125 0.0804 0.0788
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0094 0.0113
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0199 0.0182
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0093 0.0572 0.0556
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0076
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0125 0.0804 0.0788
Entamoeba histolytica hypothetical protein 0.0042 0.0199 0.2458
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.005 0.0598
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0446 0.1607
Entamoeba histolytica hypothetical protein 0.0026 0.0084 0.1017
Echinococcus granulosus chromobox protein 1 0.0076 0.0446 0.0429
Mycobacterium ulcerans hypothetical protein 0.0041 0.0188 0.0318
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0094 0.1149
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0043 0.0209 0.0192

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Binding affinity to VHL (unknown origin) at 1 mM using 40 uM of protein by NMR-CPMG analysis ChEMBL. 24436777
Activity (binding) Binding affinity to VHL (unknown origin) at 3 mM using 30 uM of protein by NMR-WaterLOGSY analysis ChEMBL. 24436777
Activity (binding) Binding affinity to VHL (unknown origin) at 1 mM using 10 uM of protein by NMR-STD analysis ChEMBL. 24436777

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.