TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 733.836 | Formula: C39H53F2NO10
H donors: 1 H acceptors: 1 LogP: 7.88 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: Fc1cc(F)cc(c1)NC(=O)O[C@H]([C@H]1O[C@@H]2O[C@@]3(C)CC[C@@H]4[C@]2([C@H]([C@H]1C)CC[C@H]4C)OO3)C[C@H]1O[C@@H]2O[C@@]3(C)CC[C@@H]4[C@]2([C@H]([C@H]1C)CC[C@H]4C)OO3
InChi: 1S/C39H53F2NO10/c1-19-7-9-28-21(3)30(44-33-38(28)26(19)11-13-36(5,47-33)49-51-38)18-31(45-35(43)42-25-16-23(40)15-24(41)17-25)32-22(4)29-10-8-20(2)27-12-14-37(6)48-34(46-32)39(27,29)52-50-37/h15-17,19-22,26-34H,7-14,18H2,1-6H3,(H,42,43)/t19-,20-,21-,22-,26+,27+,28+,29+,30-,31+,32+,33-,34-,36-,37-,38-,39-/m1/s1
InChiKey: PWNGCUALXLBLEV-FCDUGWAXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0042	0.0331	0.0213
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0055	0.048	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1256	0.1555
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0162	0.019
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.1096	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0347	0.0325
Entamoeba histolytica	hypothetical protein	0.0042	0.033	0.1803
Echinococcus granulosus	zinc finger protein	0.0023	0.0105	0.0113
Plasmodium falciparum	phd finger protein, putative	0.0034	0.0237	1
Schistosoma mansoni	microtubule-associated protein tau	0.0805	0.9302	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.008	0.0099
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0028	0.0162	0.0326
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.1096	0.1357
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0331	0.041
Entamoeba histolytica	hypothetical protein	0.0042	0.033	0.1803
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0028	0.0162	0.0809
Loa Loa (eye worm)	phosphofructokinase	0.0107	0.1096	0.1357
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.033	0.0355
Echinococcus granulosus	methyl CpG binding domain protein 2	0.002	0.0071	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0169	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0021	0.008	0.0099
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0111	0.1147	0.1233
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0162	0.019
Entamoeba histolytica	hypothetical protein	0.0042	0.033	0.1803
Schistosoma mansoni	hypothetical protein	0.0042	0.033	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0217
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0028	0.0162	0.0326
Echinococcus granulosus	jumonji domain containing protein	0.0047	0.0393	0.0423
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0331	0.0903
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0331	0.0529
Mycobacterium leprae	Probable lipase LipE	0.0042	0.0331	0.1807
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0177	1
Brugia malayi	Pre-SET motif family protein	0.0243	0.2692	0.3327
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0177	1
Onchocerca volvulus	Huntingtin homolog	0.0121	0.1256	0.1382
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0162	0.0201
Entamoeba histolytica	protein kinase domain containing protein	0.0088	0.087	0.7587
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0055	0.048	0.0468
Echinococcus multilocularis	dual specificity	0.0088	0.087	0.087
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0177	0.6186
Loa Loa (eye worm)	hypothetical protein	0.005	0.0422	0.0523
Brugia malayi	beta-lactamase	0.0042	0.0331	0.0399
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0237	0.3891
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.1096	0.1307
Loa Loa (eye worm)	hypothetical protein	0.0021	0.008	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0331	0.041
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0246	0.4513
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0175	0.0217
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.033	0.033
Entamoeba histolytica	hypothetical protein	0.0042	0.033	0.1803
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1096	0.3158
Echinococcus granulosus	microtubule associated protein 2	0.0805	0.9302	1
Giardia lamblia	PHD finger protein 15	0.0034	0.0237	1
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.1096	0.1133
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0331	0.0356
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0243	0.2692	0.3334
Onchocerca volvulus		0.07	0.8074	1
Echinococcus granulosus	geminin	0.018	0.1959	0.2106
Loa Loa (eye worm)	PHD-finger family protein	0.0034	0.0237	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0522	0.0647
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0042	0.033	0.0354
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0331	0.0331
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0034	0.0231	0.0249
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0111	0.1147	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0865	0.1071
Schistosoma mansoni	hypothetical protein	0.0024	0.012	0.0079
Echinococcus granulosus	PHD finger protein rhinoceros	0.0034	0.0237	0.0255
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.0347	0.0325
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0331	0.0529
Schistosoma mansoni	bromodomain containing protein	0.0074	0.0705	0.0711
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0246	0.0216
Loa Loa (eye worm)	platelet-activating factor acetylhydrolase	0.07	0.8074	1
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.1096	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0237	0.0293
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0237	0.6255
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0107	0.1096	0.3517
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0162	0.0809
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0331	0.041
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0331	0.0354
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0175	0.0138
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0107	0.1096	1
Mycobacterium ulcerans	beta-lactamase	0.0042	0.0331	0.247
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1096	0.3158
Echinococcus granulosus	lamin dm0	0.0029	0.0175	0.0188
Trypanosoma cruzi	phospholipase A2-like protein, putative	0.0321	0.3614	0.4444
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0028	0.0162	0.0809
Schistosoma mansoni	zinc finger protein	0.0023	0.0105	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0162	0.0201
Loa Loa (eye worm)	jmjC domain-containing protein	0.0043	0.0347	0.043
Echinococcus multilocularis	musashi	0.0029	0.0175	0.0175
Brugia malayi	Protein kinase domain containing protein	0.0088	0.087	0.1068
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0107	0.1096	1
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0177	0.3869
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0055	0.048	0.048
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.1096	1
Brugia malayi	jmjC domain containing protein	0.0111	0.1147	0.1411
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0363	0.045
Loa Loa (eye worm)	jmjC domain-containing protein	0.007	0.0663	0.0821
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.0331	0.0903
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0331	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0331	0.041
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.1096	0.1307
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0162	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0807	0.0999
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.002	0.0071	0.0071
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0331	0.0354
Onchocerca volvulus		0.0276	0.3086	0.3696
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0088	0.087	0.1026
Onchocerca volvulus		0.0029	0.0175	0.0016
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.007	0.0656	0.0656
Echinococcus granulosus	dual specificity	0.0088	0.087	0.0936
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0028	0.0162	0.0809
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0088	0.087	0.1026
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0029	0.0177	0.0159
Trypanosoma cruzi	phospholipase A1, putative	0.07	0.8074	1
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0088	0.087	0.1026
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0331	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0162	0.0809
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0331	0.0903
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0034	0.0237	0.0237
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0331	0.0307
Trypanosoma cruzi	phospholipase A2-like protein, putative	0.0321	0.3614	0.4444
Mycobacterium ulcerans	6-phosphofructokinase	0.0107	0.1096	1
Echinococcus multilocularis	lamin	0.0029	0.0175	0.0175
Echinococcus granulosus	intermediate filament protein	0.0029	0.0175	0.0188
Echinococcus multilocularis	peregrin	0.0037	0.0269	0.0269
Schistosoma mansoni	lamin	0.0029	0.0175	0.0138
Echinococcus granulosus	lamin	0.0029	0.0175	0.0188
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0028	0.0162	0.0809
Onchocerca volvulus		0.07	0.8074	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0331	0.041
Echinococcus multilocularis	6 phosphofructokinase	0.0107	0.1096	0.1096
Echinococcus multilocularis	lysine specific demethylase 5A	0.0041	0.0321	0.0321
Entamoeba histolytica	hypothetical protein	0.0088	0.087	0.7587
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0088	0.087	0.1078
Onchocerca volvulus		0.07	0.8074	1
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0162	0.019
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1096	0.3158
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0331	0.0529
Onchocerca volvulus		0.0029	0.0175	0.0016
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0237	0.3891
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0071	0.0026
Entamoeba histolytica	protein kinase, putative	0.0088	0.087	0.7587
Plasmodium vivax	SET domain protein, putative	0.0035	0.0246	0.6636
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.0331	0.0903
Leishmania major	phospholipase A1, putative	0.07	0.8074	1
Schistosoma mansoni	hypothetical protein	0.018	0.1959	0.2066
Brugia malayi	hypothetical protein	0.0042	0.033	0.0399
Echinococcus multilocularis	zinc finger protein	0.0023	0.0105	0.0105
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.1096	0.1133
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0331	0.247
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0177	0.6186
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0268	0.2992	1
Brugia malayi	hypothetical protein	0.0121	0.1256	0.1546
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0162	0.0201
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0018	0.0011
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0071	0.0026
Onchocerca volvulus		0.0042	0.0331	0.0213
Schistosoma mansoni	hypothetical protein	0.0034	0.0237	0.0205
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0246	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0865	0.1071
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0018	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0331	0.041
Loa Loa (eye worm)	hypothetical protein	0.0021	0.008	0.0099
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0034	0.0237	0.0205
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0331	0.0903
Brugia malayi	Pre-SET motif family protein	0.0035	0.0246	0.0294
Onchocerca volvulus		0.0035	0.0246	0.0107
Echinococcus multilocularis	jumonji domain containing protein	0.0047	0.0393	0.0393
Echinococcus granulosus	lysine specific demethylase 5A	0.0043	0.0347	0.0373
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0331	0.041
Brugia malayi	Bromodomain containing protein	0.0087	0.0866	0.1062
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0331	0.0399
Trypanosoma brucei	phospholipase A1, putative	0.07	0.8074	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.0331	0.0903
Onchocerca volvulus		0.0042	0.0331	0.0213
Onchocerca volvulus	Alhambra homolog	0.0034	0.0237	0.0094
Schistosoma mansoni	lamin	0.0029	0.0175	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0396	0.049
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0331	0.0354
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1096	0.3158
Brugia malayi	Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein	0.07	0.8074	1
Brugia malayi	beta-lactamase family protein	0.0042	0.0331	0.0399
Brugia malayi	PHD-finger family protein	0.0029	0.0179	0.021
Trypanosoma cruzi	phospholipase A1, putative	0.07	0.8074	1
Leishmania major	ATP-dependent phosphofructokinase	0.0107	0.1096	0.1307
Mycobacterium ulcerans	lipase LipD	0.0042	0.0331	0.247
Brugia malayi	PHD-finger family protein	0.0034	0.0237	0.0283
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0162	0.0809
Brugia malayi	Bromodomain containing protein	0.0045	0.0362	0.0438
Brugia malayi	Bromodomain containing protein	0.0037	0.0269	0.0323
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0175	0.0217
Schistosoma mansoni	hypothetical protein	0.018	0.1959	0.2066
Echinococcus multilocularis	microtubule associated protein 2	0.0805	0.9302	0.9302
Schistosoma mansoni	jumonji domain containing protein	0.0088	0.0877	0.0898
Toxoplasma gondii	ABC1 family protein	0.0042	0.0331	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.0331	0.0903
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0246	0.0246
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.0331	0.1807
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.0331	0.0903
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.0331	0.247
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0088	0.087	0.1026
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0162	0.0809
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.0331	0.0903
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.008	0.0045
Echinococcus granulosus	peregrin	0.0037	0.0269	0.0289
Trichomonas vaginalis	esterase, putative	0.0042	0.0331	0.0529
Loa Loa (eye worm)	PHD-finger family protein	0.0024	0.012	0.0149
Entamoeba histolytica	protein kinase, putative	0.0088	0.087	0.7587
Leishmania major	hypothetical protein, conserved	0.0042	0.0331	0.0354
Loa Loa (eye worm)	bromodomain containing protein	0.0021	0.0079	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0021	0.008	0.0099
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0146	0.0107
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0331	0.0307
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.087	0.089
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.0331	0.247
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0162	0.0144
Brugia malayi	intermediate filament protein	0.0029	0.0175	0.0206
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0042	0.033	0.033
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.0331	0.0903
Brugia malayi	phosphofructokinase	0.0107	0.1096	0.1347
Brugia malayi	beta-lactamase family protein	0.0042	0.0331	0.0399
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0331	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1256	0.1555
Onchocerca volvulus	Huntingtin homolog	0.0121	0.1256	0.1382
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.1096	0.1357
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0331	0.041
Trichomonas vaginalis	set domain proteins, putative	0.0276	0.3086	1
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.033	0.0306
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0146	0.0146
Echinococcus granulosus	6 phosphofructokinase	0.0107	0.1096	0.1178
Loa Loa (eye worm)	hypothetical protein	0.0055	0.048	0.0595
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0175	0.0206
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.007	0.0656	0.0705
Echinococcus granulosus	histone lysine methyltransferase setb	0.0055	0.048	0.0516
Echinococcus multilocularis	geminin	0.018	0.1959	0.1959
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0146	0.0157
Brugia malayi	jmjC domain containing protein	0.0043	0.0347	0.0419
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0162	0.0144
Brugia malayi	6-phosphofructokinase	0.0107	0.1096	0.1347
Brugia malayi	6-phosphofructokinase	0.0107	0.1096	0.1347
Echinococcus multilocularis	lamin dm0	0.0029	0.0175	0.0175
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0177	0.3869

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	> 99.9 %	Antimalarial activity against Plasmodium berghei ANKA infected in C57BL/6J mouse assessed as decrease of parasitemia level at 5 mg/kg, po administered after 24 hrs post infection measured after 3 days in presence of 15 mg/kg of mefloquine hydrochloride relative to control	ChEMBL.	24508128

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3120897

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1836263