TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 366.41 | Formula: C21H22N2O4
H donors: 1 H acceptors: 4 LogP: 3.02 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CC1CC(=O)C2=C(C1)NC1=C(C2c2ccc(cc2)[N+](=O)[O-])C(=O)CC(C1)C
InChi: 1S/C21H22N2O4/c1-11-7-15-20(17(24)9-11)19(13-3-5-14(6-4-13)23(26)27)21-16(22-15)8-12(2)10-18(21)25/h3-6,11-12,19,22H,7-10H2,1-2H3
InChiKey: LGGPLLAADDMXIZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0348	0.0389
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0224	0.262	0.2911
Schistosoma mansoni	peroxidasin	0.0052	0.0365	0.0384
Trypanosoma cruzi	calcium-translocating P-type ATPase, putative	0.0041	0.0213	0.2757
Onchocerca volvulus		0.0224	0.262	0.9549
Echinococcus multilocularis	expressed conserved protein	0.009	0.0856	0.0836
Echinococcus multilocularis	Ca2+ transporting ATPase plasma membrane	0.0081	0.074	0.0719
Schistosoma mansoni	hypothetical protein	0.0039	0.0198	0.0196
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, putative	0.0245	0.2896	0.3224
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.0365	0.0408
Echinococcus granulosus	sodium:potassium transporting ATPase subunit	0.0224	0.262	0.2911
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0194	0.2221	0.2483
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0706	0.8946	1
Onchocerca volvulus	Chorion peroxidase homolog	0.0052	0.0365	0.1258
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0047	0.0295	0.031
Echinococcus multilocularis	nervana 2	0.0185	0.2111	0.2094
Brugia malayi	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0081	0.074	0.0827
Echinococcus granulosus	peroxidasin	0.0052	0.0365	0.0384
Trypanosoma brucei	calcium motive p-type ATPase, putative	0.0081	0.074	0.9575
Echinococcus granulosus	RUN	0.0039	0.0193	0.0191
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0224	0.2614	0.2921
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0083	0.0773	1
Echinococcus multilocularis	sodium:potassium transporting ATPase subunit	0.0224	0.262	0.2603
Schistosoma mansoni	polycystin 1-related	0.0039	0.0193	0.0191
Entamoeba histolytica	hypothetical protein	0.0461	0.5729	0.6396
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0706	0.8946	1
Leishmania major	calcium motive p-type ATPase, putative	0.0081	0.074	0.9575
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.0365	0.0408
Brugia malayi	hypothetical protein	0.0158	0.1756	0.1963
Schistosoma mansoni	hypothetical protein	0.0039	0.0198	0.0196
Brugia malayi	PAS domain containing protein	0.0047	0.0298	0.0333
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0083	0.0773	0.0637
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0083	0.0773	0.0637
Brugia malayi	MH2 domain containing protein	0.0116	0.1199	0.134
Onchocerca volvulus	Peroxidasin homolog	0.0052	0.0365	0.1258
Brugia malayi	dUTP diphosphatase	0.0706	0.8946	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0217	0.0218
Onchocerca volvulus		0.0039	0.0193	0.0628
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0081	0.074	0.0804
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0081	0.074	0.9575
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0059	0.0041
Echinococcus multilocularis	nervana 2	0.0224	0.262	0.2603
Onchocerca volvulus		0.0052	0.0365	0.1258
Echinococcus multilocularis	nervana 2	0.0185	0.2111	0.2094
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0083	0.0773	1
Brugia malayi	intermediate filament protein	0.0026	0.0022	0.0025
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0097	0.0952	0.1041
Loa Loa (eye worm)	hypothetical protein	0.0168	0.1882	0.2104
Brugia malayi	Membrane calcium atpase protein 3	0.0081	0.074	0.0827
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0365	0.0408
Brugia malayi	CHE-14 protein	0.0041	0.0217	0.0242
Brugia malayi	hypothetical protein	0.0229	0.2689	0.3006
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0083	0.0773	1
Schistosoma mansoni	hypothetical protein	0.0047	0.0293	0.0303
Onchocerca volvulus		0.0233	0.2742	1
Loa Loa (eye worm)	calcium ATPase	0.0049	0.0321	0.0359
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0146	0.1595	0.1783
Echinococcus multilocularis	transfer RNA-Lys	0.0035	0.0137	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0314	0.0351
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0113	0.0126
Schistosoma mansoni	lipoxygenase	0.0164	0.1829	0.2025
Trypanosoma brucei	calcium-transporting ATPase, putative	0.0051	0.0348	0.45
Entamoeba histolytica	hypothetical protein	0.0706	0.8946	1
Trypanosoma cruzi	plasma-membrane proton-efflux P-type ATPase, putative	0.0041	0.0213	0.2757
Echinococcus granulosus	nervana 2	0.0185	0.2111	0.2341
Echinococcus multilocularis	survival motor neuron protein 1	0.0229	0.2689	0.2672
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0224	0.262	0.2911
Echinococcus granulosus	Niemann Pick C1 protein	0.0136	0.147	0.1622
Brugia malayi	calcium ATPase	0.0041	0.0213	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0213	0.0238
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0083	0.0773	0.0841
Entamoeba histolytica	hypothetical protein	0.0245	0.2896	0.3224
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0045	0.0025
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0059	0.0037
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0224	0.262	0.2911
Brugia malayi	hypothetical protein	0.0039	0.0193	0.0216
Schistosoma mansoni	rab6-interacting	0.0039	0.0193	0.0191
Schistosoma mansoni	sodium / potassium ATPase beta chain	0.0185	0.2111	0.2341
Loa Loa (eye worm)	hypothetical protein	0.0224	0.2614	0.2921
Onchocerca volvulus		0.0185	0.2111	0.768
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0083	0.0773	0.0625
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0039	0.0193	0.0171
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0083	0.0773	1
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.009	0.0855	0.0834
Brugia malayi	hypothetical protein	0.0035	0.0137	0.0153
Mycobacterium tuberculosis	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)	0.0245	0.2896	1
Plasmodium vivax	P-type ATPase4, putative	0.009	0.0855	0.0956
Loa Loa (eye worm)	hypothetical protein	0.005	0.0338	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0309	0.0345
Brugia malayi	Pax transcription factor protein 2	0.0233	0.2742	0.3066
Schistosoma mansoni	lipoxygenase	0.0234	0.2754	0.3062
Leishmania major	calcium-translocating P-type ATPase	0.0083	0.0773	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0039	0.0193	0.0191
Echinococcus granulosus	nervana 2	0.0185	0.2111	0.2341
Brugia malayi	hypoxia-induced factor 1	0.0146	0.1595	0.1783
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0016	0.0018
Brugia malayi	E1-E2 ATPase family protein	0.0056	0.041	0.0459
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0083	0.0773	0.0845
Entamoeba histolytica	hypothetical protein	0.0706	0.8946	1
Echinococcus multilocularis	Na+:K+ ATPase alpha subunit	0.0215	0.2498	0.2482
Onchocerca volvulus	Peroxidase homolog	0.0052	0.0365	0.1258
Trypanosoma brucei	calcium-translocating P-type ATPase	0.0081	0.074	0.9575
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0365	0.0408
Onchocerca volvulus	Peroxidasin homolog	0.0052	0.0365	0.1258
Schistosoma mansoni	loxhd1	0.0039	0.0193	0.0191
Echinococcus multilocularis	peroxidasin	0.0052	0.0365	0.0343
Echinococcus multilocularis	calcium transporting atpase	0.0081	0.074	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0365	0.0408
Loa Loa (eye worm)	hypothetical protein	0.003	0.0071	0.008
Schistosoma mansoni	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0706	0.8946	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0059	0.0041
Brugia malayi	Na,K-ATPase alpha subunit	0.0224	0.2614	0.2921
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0365	0.0408
Wolbachia endosymbiont of Brugia malayi	dUTPase	0.0706	0.8946	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.2328	0.2602
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.0049	0.0321	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0365	0.0408
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0083	0.0773	0.0752
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0081	0.074	0.0804
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0049	0.0328	0.4246
Echinococcus multilocularis	tumor protein p63	0.0328	0.398	0.3966
Mycobacterium ulcerans	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0245	0.2896	1
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0706	0.8946	1
Toxoplasma gondii	plasma membrane-type Ca(2+)-ATPase A1 PMCAA1	0.0081	0.074	0.0827
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0194	0.2221	0.2483
Loa Loa (eye worm)	blistered cuticle protein 3	0.0052	0.0365	0.0408
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0081	0.074	0.9575
Leishmania major	calcium-transporting ATPase, putative	0.0081	0.074	0.9575
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0217	0.0218
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0059	0.0041
Echinococcus multilocularis	Niemann Pick C1 protein	0.0136	0.147	0.1451
Loa Loa (eye worm)	hypothetical protein	0.0158	0.1756	0.1963
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.009	0.0855	0.0933
Schistosoma mansoni	rab6-interacting	0.0039	0.0193	0.0191
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0309	0.0321
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.0365	0.0408
Plasmodium falciparum	LCCL domain-containing protein	0.0039	0.0193	0.0216
Mycobacterium leprae	PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE)	0.0245	0.2896	1
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0083	0.0773	0.0637
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.009	0.0855	0.0937
Plasmodium vivax	calcium-transporting ATPase, putative	0.009	0.0855	0.0956
Echinococcus multilocularis	dUTP pyrophosphatase	0.0706	0.8946	0.8944
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0365	0.0408
Entamoeba histolytica	hypothetical protein	0.0035	0.0137	0.0133
Onchocerca volvulus		0.0047	0.0293	0.0995
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0022	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0217	0.0242
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.009	0.0855	0.0731
Plasmodium falciparum	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0706	0.8946	1
Loa Loa (eye worm)	animal heme peroxidase	0.0052	0.0365	0.0408
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0059	0.0041
Schistosoma mansoni	single-minded	0.0047	0.0298	0.0309
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0706	0.8946	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0083	0.0773	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0193	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0932	0.1042
Loa Loa (eye worm)	hypothetical protein	0.003	0.0071	0.008
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0365	0.0408
Echinococcus granulosus	lipoxygenase domain containing protein	0.0039	0.0193	0.0191
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0293	0.0271
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0083	0.0773	1
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.009	0.0855	0.0933
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0234	0.2754	0.2738
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0365	0.0408
Leishmania major	P-type H -ATPase, putative	0.0049	0.0328	0.4246
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0217	0.0242
Schistosoma mansoni	hypothetical protein	0.0033	0.0113	0.0101
Onchocerca volvulus	Dual oxidase homolog	0.0052	0.0365	0.1258
Entamoeba histolytica	deoxycytidine triphosphate deaminase, putative	0.0245	0.2896	0.3224
Schistosoma mansoni	patched 1	0.0041	0.0217	0.0218
Onchocerca volvulus		0.0052	0.0365	0.1258
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0083	0.0773	0.0637
Brugia malayi	Pre-SET motif family protein	0.0202	0.2328	0.2602
Brugia malayi	hypothetical protein	0.0039	0.0193	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0224	0.262	0.2928
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0217	0.0195
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.009	0.0855	0.26
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0081	0.074	0.0804
Entamoeba histolytica	hypothetical protein	0.0035	0.0137	0.0133
Loa Loa (eye worm)	sodium potassium adenosine triphosphatase	0.0041	0.0213	0.0238
Echinococcus granulosus	plasma membrane calcium transporting ATPase	0.0081	0.074	0.0804
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0039	0.0193	0.0171
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.0049	0.0321	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0022	0.0025
Echinococcus granulosus	single minded 2	0.0035	0.0137	0.0129
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.0365	0.0408
Echinococcus granulosus	tumor protein p63	0.0328	0.398	0.4435
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0049	0.0328	0.0127
Echinococcus granulosus	Na:K ATPase alpha subunit	0.0215	0.2498	0.2775
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0059	0.0037
Trichomonas vaginalis	set domain proteins, putative	0.023	0.2694	0.2838
Entamoeba histolytica	hypothetical protein	0.0035	0.0137	0.0133
Onchocerca volvulus		0.0035	0.0137	0.0423
Brugia malayi	Niemann-Pick C1 protein precursor	0.0095	0.0932	0.1042
Entamoeba histolytica	hypothetical protein	0.0461	0.5729	0.6396
Plasmodium vivax	multidomain scavenger receptor, putative	0.0039	0.0193	0.0216
Echinococcus granulosus	expressed conserved protein	0.009	0.0856	0.0934
Loa Loa (eye worm)	animal heme peroxidase	0.0052	0.0365	0.0408
Toxoplasma gondii	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.0706	0.8946	1
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0083	0.0773	0.0864
Trypanosoma brucei	P-type H+-ATPase, putative	0.0049	0.0328	0.4246
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative	0.0706	0.8946	1
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0224	0.262	0.2603
Schistosoma mansoni	hypothetical protein	0.0164	0.1836	0.2032
Brugia malayi	hypothetical protein	0.0052	0.0365	0.0408
Treponema pallidum	deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)	0.0706	0.8946	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0314	0.0351
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0185	0.2111	0.2341
Brugia malayi	bHLH-PAS transcription factor	0.0035	0.0137	0.0154
Loa Loa (eye worm)	animal heme peroxidase	0.0052	0.0365	0.0408
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0083	0.0773	0.0845
Schistosoma mansoni	peroxidasin	0.0052	0.0365	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0224	0.262	0.2928
Onchocerca volvulus		0.0217	0.2531	0.9224
Echinococcus multilocularis	protein patched	0.0041	0.0217	0.0195
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.009	0.0855	0.0956
Schistosoma mansoni	hypothetical protein	0.0164	0.1836	0.2032
Loa Loa (eye worm)	doublecortin family protein	0.0039	0.0193	0.0216
Brugia malayi	Peroxidasin	0.0052	0.0365	0.0408
Echinococcus multilocularis	Niemann Pick C1 protein	0.0095	0.0932	0.0912
Schistosoma mansoni	ATPase	0.0083	0.0773	0.0841
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0059	0.0066
Trypanosoma cruzi	calcium-transporting ATPase, putative	0.0051	0.0348	0.45
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1199	0.134
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0083	0.0773	0.0637
Echinococcus multilocularis	nervana 2	0.0224	0.262	0.2603
Mycobacterium ulcerans	cation-transporter ATPase I CtpI	0.0053	0.0381	0.0881
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0224	0.262	0.2911
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0185	0.2111	0.2341
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0193	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0773	0.0864
Schistosoma mansoni	hypothetical protein	0.0039	0.0198	0.0196
Echinococcus multilocularis	RUN	0.0039	0.0193	0.0171
Trichomonas vaginalis	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.0706	0.8946	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0225	0.2627	0.2937
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0217	0.2531	0.8677
Brugia malayi	follicle stimulating hormone receptor	0.0225	0.2627	0.2937
Leishmania major	P-type H -ATPase, putative	0.0049	0.0328	0.4246
Loa Loa (eye worm)	hypothetical protein	0.0134	0.1438	0.1607
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0185	0.2111	0.2094
Loa Loa (eye worm)	E1-E2 ATPase	0.0049	0.0328	0.0367
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0293	0.0303
Onchocerca volvulus		0.0039	0.0193	0.0628
Trypanosoma cruzi	calcium-translocating P-type ATPase, putative	0.0034	0.0124	0.1602
Onchocerca volvulus	Peroxidase homolog	0.0052	0.0365	0.1258
Schistosoma mansoni	ATPase	0.0083	0.0773	0.0841
Loa Loa (eye worm)	animal heme peroxidase	0.0052	0.0365	0.0408
Schistosoma mansoni	hypothetical protein	0.0039	0.0193	0.0191
Plasmodium falciparum	calcium-transporting ATPase	0.0081	0.074	0.0827
Echinococcus granulosus	calcium transporting atpase	0.0081	0.074	0.0804
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0022	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1695	0.1894
Loa Loa (eye worm)	dUTP diphosphatase	0.0706	0.8946	1
Onchocerca volvulus		0.0029	0.0059	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0365	0.0408
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0041	0.0213	0.2757
Schistosoma mansoni	transmemberane protein	0.0224	0.262	0.2911
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0083	0.0773	1
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0083	0.0773	0.0845
Brugia malayi	Animal haem peroxidase family protein	0.0052	0.0365	0.0408
Plasmodium vivax	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.0706	0.8946	1
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative	0.0706	0.8946	1
Chlamydia trachomatis	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0706	0.8946	1
Echinococcus granulosus	survival motor neuron protein 1	0.0229	0.2689	0.2988
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0365	0.0408
Echinococcus multilocularis	plasma membrane calcium transporting ATPase	0.0081	0.074	0.0719
Loa Loa (eye worm)	calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0051	0.0348	0.0389
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0137	0.0129
Echinococcus granulosus	Niemann Pick C1 protein	0.0095	0.0932	0.102
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0224	0.262	0.2603
Schistosoma mansoni	na+/k+ atpase alpha subunit	0.0215	0.2498	0.2775
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0081	0.074	0.0804
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0137	0.0115
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0293	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0229	0.2689	0.3006
Echinococcus granulosus	dUTP pyrophosphatase	0.0706	0.8946	1
Leishmania major	P-type ATPase, putative	0.0081	0.074	0.9575
Brugia malayi	Doublecortin family protein	0.0039	0.0193	0.0216
Echinococcus multilocularis	Polycystic kidney disease protein	0.0039	0.0193	0.0171
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0137	0.0129
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0081	0.074	0.0599
Brugia malayi	Probable calcium-transporting ATPase KIAA0703	0.0051	0.0348	0.0389
Echinococcus granulosus	nervana 2	0.0224	0.262	0.2911
Echinococcus multilocularis	geminin	0.0164	0.1836	0.1818
Entamoeba histolytica	plasma membrane calcium-transporting ATPase 1, putative	0.0043	0.0239	0.0247
Mycobacterium ulcerans	deoxycytidine triphosphate deaminase	0.0245	0.2896	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0365	0.0408
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0095	0.0932	0.1024
Onchocerca volvulus		0.0048	0.0309	0.1052
Plasmodium vivax	SET domain protein, putative	0.0029	0.0059	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0365	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0365	0.0408
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0234	0.2754	0.3062
Toxoplasma gondii	E1-E2 ATPase subfamily protein	0.0041	0.0213	0.0238
Brugia malayi	calcium ATPase	0.004	0.0206	0.023
Brugia malayi	Sodium/potassium-transporting ATPase alpha-3 chain, putative	0.0041	0.0213	0.0238
Echinococcus granulosus	Ca2 transporting ATPase plasma membrane	0.0081	0.074	0.0804
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0059	0.0041
Schistosoma mansoni	hypothetical protein	0.0039	0.0198	0.0196
Schistosoma mansoni	calcium-transporting atpase 2 (atpase 2)	0.0081	0.074	0.0804
Onchocerca volvulus		0.023	0.2694	0.9822
Onchocerca volvulus		0.0052	0.0365	0.1258
Trypanosoma brucei	P-type H+-ATPase, putative	0.0049	0.0328	0.4246
Brugia malayi	Pre-SET motif family protein	0.0029	0.0059	0.0066
Schistosoma mansoni	hypothetical protein	0.0035	0.0137	0.0129
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0083	0.0773	0.0637
Loa Loa (eye worm)	pax transcription factor protein 2	0.0233	0.2742	0.3066
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0049	0.0328	0.4246
Toxoplasma gondii	P-type ATPase4, putative	0.009	0.0855	0.0956
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0224	0.2614	0.2904
Toxoplasma gondii	P-type ATPase PMA1	0.0049	0.0328	0.0367
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.009	0.0855	0.0956
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0022	0.0025
Entamoeba histolytica	hypothetical protein	0.0035	0.0137	0.0133
Giardia lamblia	Potassium-transporting ATPase alpha chain 1	0.0215	0.2498	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0113	0.0126
Echinococcus granulosus	geminin	0.0164	0.1836	0.2032
Echinococcus granulosus	Polycystic kidney disease protein	0.0039	0.0193	0.0191
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1199	0.134
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0314	0.0351
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0083	0.0773	1
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0083	0.0773	0.0637
Schistosoma mansoni	aryl hydrocarbon receptor	0.0047	0.0298	0.0309
Echinococcus granulosus	nervana 2	0.0224	0.262	0.2911
Brugia malayi	Blistered cuticle protein 3	0.0052	0.0365	0.0408
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0314	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0059	0.0066
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.009	0.0855	0.0834
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0083	0.0773	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0365	0.0408

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2261876

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1837627