Detailed information for compound 1837627

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.41 | Formula: C21H22N2O4
  • H donors: 1 H acceptors: 4 LogP: 3.02 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CC(=O)C2=C(C1)NC1=C(C2c2ccc(cc2)[N+](=O)[O-])C(=O)CC(C1)C
  • InChi: 1S/C21H22N2O4/c1-11-7-15-20(17(24)9-11)19(13-3-5-14(6-4-13)23(26)27)21-16(22-15)8-12(2)10-18(21)25/h3-6,11-12,19,22H,7-10H2,1-2H3
  • InChiKey: LGGPLLAADDMXIZ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0052 0.0365 0.1258
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0952 0.1041
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0081 0.074 0.0804
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0081 0.074 0.0599
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0137 0.0129
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0408
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0083 0.0773 0.0864
Onchocerca volvulus 0.0052 0.0365 0.1258
Trichomonas vaginalis set domain proteins, putative 0.023 0.2694 0.2838
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2689 0.2672
Leishmania major P-type H -ATPase, putative 0.0049 0.0328 0.4246
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0215 0.2498 0.2775
Entamoeba histolytica hypothetical protein 0.0706 0.8946 1
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0081 0.074 0.0804
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0049 0.0321 0.0339
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0224 0.262 0.2911
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0932 0.1042
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0041 0.0213 0.2757
Entamoeba histolytica hypothetical protein 0.0706 0.8946 1
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0049 0.0321 0.0359
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0083 0.0773 1
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0215 0.2498 0.2482
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0217 0.0218
Brugia malayi Pax transcription factor protein 2 0.0233 0.2742 0.3066
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0041 0.0213 0.2757
Loa Loa (eye worm) hypothetical protein 0.0041 0.0213 0.0238
Brugia malayi follicle stimulating hormone receptor 0.0225 0.2627 0.2937
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1199 0.134
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0081 0.074 0.0719
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0408
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0365 0.0408
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0408
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0083 0.0773 1
Trypanosoma brucei calcium-translocating P-type ATPase 0.0081 0.074 0.9575
Schistosoma mansoni loxhd1 0.0039 0.0193 0.0191
Echinococcus granulosus single minded 2 0.0035 0.0137 0.0129
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0083 0.0773 0.0637
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0083 0.0773 0.0841
Brugia malayi Membrane calcium atpase protein 3 0.0081 0.074 0.0827
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0113 0.0126
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0081 0.074 0.0804
Echinococcus granulosus expressed conserved protein 0.009 0.0856 0.0934
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0706 0.8946 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0193 0.0171
Brugia malayi Doublecortin family protein 0.0039 0.0193 0.0216
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.009 0.0855 0.0956
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0365 0.0408
Schistosoma mansoni hypothetical protein 0.0035 0.0137 0.0129
Onchocerca volvulus 0.0047 0.0293 0.0995
Brugia malayi hypothetical protein 0.0039 0.0193 0.0216
Echinococcus multilocularis protein dispatched 1 0.0047 0.0293 0.0271
Loa Loa (eye worm) hypothetical protein 0.005 0.0338 0.0378
Leishmania major calcium-transporting ATPase, putative 0.0081 0.074 0.9575
Schistosoma mansoni single-minded 0.0047 0.0298 0.0309
Brugia malayi MH2 domain containing protein 0.0116 0.1199 0.134
Echinococcus granulosus calcium transporting atpase 0.0081 0.074 0.0804
Brugia malayi intermediate filament protein 0.0026 0.0022 0.0025
Brugia malayi hypothetical protein 0.0039 0.0193 0.0216
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0224 0.2614 0.2904
Trypanosoma brucei calcium-transporting ATPase, putative 0.0051 0.0348 0.45
Brugia malayi CHE-14 protein 0.0041 0.0217 0.0242
Onchocerca volvulus 0.0233 0.2742 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0193 0.0191
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0365 0.1258
Schistosoma mansoni rab6-interacting 0.0039 0.0193 0.0191
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0185 0.2111 0.2341
Schistosoma mansoni hypothetical protein 0.0033 0.0113 0.0101
Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0706 0.8946 1
Echinococcus granulosus Na:K ATPase alpha subunit 0.0215 0.2498 0.2775
Trypanosoma cruzi P-type H+-ATPase, putative 0.0041 0.0213 0.2757
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0137 0.0154
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0185 0.2111 0.2341
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0408
Plasmodium vivax deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0706 0.8946 1
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0083 0.0773 1
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.009 0.0855 0.0834
Loa Loa (eye worm) hypothetical protein 0.0224 0.262 0.2928
Loa Loa (eye worm) hypothetical protein 0.0039 0.0193 0.0216
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, putative 0.0245 0.2896 0.3224
Plasmodium falciparum calcium-transporting ATPase 0.0081 0.074 0.0827
Schistosoma mansoni hypothetical protein 0.0047 0.0293 0.0303
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0051 0.0348 0.45
Echinococcus granulosus nervana 2 0.0224 0.262 0.2911
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.009 0.0855 0.0834
Echinococcus multilocularis nervana 2 0.0224 0.262 0.2603
Brugia malayi Blistered cuticle protein 3 0.0052 0.0365 0.0408
Onchocerca volvulus 0.0039 0.0193 0.0628
Trichomonas vaginalis cation-transporting ATPase, putative 0.0083 0.0773 0.0637
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0083 0.0773 0.0625
Loa Loa (eye worm) hypothetical protein 0.003 0.0071 0.008
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.2627 0.2937
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0081 0.074 0.0719
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0053 0.0381 0.0881
Schistosoma mansoni hypothetical protein 0.0039 0.0198 0.0196
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0081 0.074 0.0804
Onchocerca volvulus 0.0052 0.0365 0.1258
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0185 0.2111 0.2094
Loa Loa (eye worm) hypothetical protein 0.0229 0.2689 0.3006
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0217 0.0242
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0309 0.0321
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0408
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0932 0.0912
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0408
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0051 0.0348 0.0389
Onchocerca volvulus Chorion peroxidase homolog 0.0052 0.0365 0.1258
Trichomonas vaginalis cation-transporting ATPase, putative 0.0083 0.0773 0.0637
Schistosoma mansoni hypothetical protein 0.0039 0.0198 0.0196
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0217 0.0218
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0059 0.0041
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0083 0.0773 0.0637
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0043 0.0239 0.0247
Schistosoma mansoni hypothetical protein 0.0039 0.0198 0.0196
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0137 0.0115
Trichomonas vaginalis cation-transporting ATPase, putative 0.0083 0.0773 0.0637
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0083 0.0773 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0293 0.0303
Entamoeba histolytica hypothetical protein 0.0035 0.0137 0.0133
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0293 0.0328
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.147 0.1622
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0314 0.0351
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0224 0.262 0.2603
Entamoeba histolytica hypothetical protein 0.0035 0.0137 0.0133
Schistosoma mansoni lipoxygenase 0.0234 0.2754 0.3062
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0022 0.0025
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0081 0.074 0.0827
Echinococcus granulosus nervana 2 0.0185 0.2111 0.2341
Schistosoma mansoni ATPase 0.0083 0.0773 0.0841
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0408
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0365 0.0408
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0083 0.0773 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1199 0.134
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0224 0.262 0.2911
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0059 0.0041
Echinococcus granulosus dUTP pyrophosphatase 0.0706 0.8946 1
Brugia malayi calcium ATPase 0.0041 0.0213 0.0238
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0234 0.2754 0.2738
Echinococcus multilocularis protein patched 0.0041 0.0217 0.0195
Plasmodium vivax SET domain protein, putative 0.0029 0.0059 0.0066
Trypanosoma brucei P-type H+-ATPase, putative 0.0049 0.0328 0.4246
Onchocerca volvulus 0.0048 0.0309 0.1052
Echinococcus multilocularis nervana 2 0.0185 0.2111 0.2094
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2689 0.2988
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0059 0.0066
Entamoeba histolytica hypothetical protein 0.0035 0.0137 0.0133
Echinococcus granulosus nervana 2 0.0224 0.262 0.2911
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0224 0.2614 0.2921
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0083 0.0773 0.0845
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0193 0.0171
Brugia malayi calcium ATPase 0.004 0.0206 0.023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0059 0.0041
Loa Loa (eye worm) hypothetical protein 0.0158 0.1756 0.1963
Schistosoma mansoni ATPase 0.0083 0.0773 0.0841
Loa Loa (eye worm) hypothetical protein 0.0134 0.1438 0.1607
Schistosoma mansoni hypothetical protein 0.0164 0.1836 0.2032
Loa Loa (eye worm) hypothetical protein 0.0083 0.0773 0.0864
Brugia malayi E1-E2 ATPase family protein 0.0056 0.041 0.0459
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0365 0.0408
Onchocerca volvulus 0.0035 0.0137 0.0423
Echinococcus multilocularis nervana 2 0.0185 0.2111 0.2094
Plasmodium vivax P-type ATPase4, putative 0.009 0.0855 0.0956
Schistosoma mansoni rab6-interacting 0.0039 0.0193 0.0191
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0083 0.0773 1
Leishmania major P-type ATPase, putative 0.0081 0.074 0.9575
Loa Loa (eye worm) hypothetical protein 0.003 0.0071 0.008
Echinococcus multilocularis RUN 0.0039 0.0193 0.0171
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2328 0.2602
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0194 0.2221 0.2483
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0706 0.8946 1
Schistosoma mansoni hypothetical protein 0.0164 0.1836 0.2032
Brugia malayi hypothetical protein 0.0158 0.1756 0.1963
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0083 0.0773 0.0845
Loa Loa (eye worm) hypothetical protein 0.0029 0.0059 0.0066
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0041 0.0213 0.0238
Loa Loa (eye worm) dUTP diphosphatase 0.0706 0.8946 1
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0224 0.262 0.2911
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0932 0.1024
Echinococcus multilocularis calcium transporting atpase 0.0081 0.074 0.0719
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0217 0.0195
Schistosoma mansoni lipoxygenase 0.0164 0.1829 0.2025
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.009 0.0855 0.0956
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0059 0.0037
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0408
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0083 0.0773 1
Schistosoma mansoni deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0706 0.8946 1
Onchocerca volvulus 0.023 0.2694 0.9822
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0137 0.0115
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0025
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0298 0.0309
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0059 0.0037
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0137 0.0129
Mycobacterium leprae PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE) 0.0245 0.2896 1
Toxoplasma gondii deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0706 0.8946 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0059 0.0041
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0224 0.262 0.2603
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0185 0.2111 0.2341
Loa Loa (eye worm) hypothetical protein 0.0048 0.0314 0.0351
Entamoeba histolytica hypothetical protein 0.0461 0.5729 0.6396
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0081 0.074 0.9575
Loa Loa (eye worm) hypothetical protein 0.0168 0.1882 0.2104
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative 0.0706 0.8946 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0234 0.2754 0.3062
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0081 0.074 0.9575
Echinococcus granulosus peroxidasin 0.0052 0.0365 0.0384
Onchocerca volvulus 0.0039 0.0193 0.0628
Loa Loa (eye worm) hypothetical protein 0.0041 0.0217 0.0242
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0051 0.0348 0.0389
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.147 0.1451
Mycobacterium ulcerans deoxycytidine triphosphate deaminase 0.0245 0.2896 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0193 0.0171
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0081 0.074 0.0804
Trypanosoma brucei P-type H+-ATPase, putative 0.0049 0.0328 0.4246
Onchocerca volvulus Peroxidase homolog 0.0052 0.0365 0.1258
Echinococcus granulosus nervana 2 0.0185 0.2111 0.2341
Echinococcus granulosus RUN 0.0039 0.0193 0.0191
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0224 0.262 0.2911
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0224 0.262 0.2911
Schistosoma mansoni peroxidasin 0.0052 0.0365 0.0384
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0932 0.102
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0081 0.074 0.9575
Echinococcus multilocularis dUTP pyrophosphatase 0.0706 0.8946 0.8944
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0314 0.0351
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0034 0.0124 0.1602
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0706 0.8946 1
Mycobacterium ulcerans deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0245 0.2896 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0049 0.0328 0.0127
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0041 0.0213 0.0238
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0408
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0083 0.0773 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0408
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0706 0.8946 1
Loa Loa (eye worm) hypothetical protein 0.0224 0.2614 0.2921
Loa Loa (eye worm) hypothetical protein 0.0224 0.262 0.2928
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0365 0.0408
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0081 0.074 0.0804
Brugia malayi Na,K-ATPase alpha subunit 0.0224 0.2614 0.2921
Echinococcus multilocularis expressed conserved protein 0.009 0.0856 0.0836
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0408
Brugia malayi Pre-SET motif family protein 0.0202 0.2328 0.2602
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.009 0.0855 0.0731
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0041 0.0213 0.0238
Schistosoma mansoni hypothetical protein 0.0039 0.0198 0.0196
Entamoeba histolytica deoxycytidine triphosphate deaminase, putative 0.0245 0.2896 0.3224
Echinococcus multilocularis geminin 0.0164 0.1836 0.1818
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0047 0.0295 0.031
Onchocerca volvulus 0.0224 0.262 0.9549
Entamoeba histolytica hypothetical protein 0.0245 0.2896 0.3224
Loa Loa (eye worm) blistered cuticle protein 3 0.0052 0.0365 0.0408
Loa Loa (eye worm) hypothetical protein 0.0039 0.0193 0.0216
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.2742 0.3066
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0022 0.0025
Toxoplasma gondii P-type ATPase PMA1 0.0049 0.0328 0.0367
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0081 0.074 0.0827
Schistosoma mansoni transmemberane protein 0.0224 0.262 0.2911
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0408
Echinococcus multilocularis peroxidasin 0.0052 0.0365 0.0343
Leishmania major calcium motive p-type ATPase, putative 0.0081 0.074 0.9575
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0217 0.2531 0.8677
Loa Loa (eye worm) E1-E2 ATPase 0.0049 0.0328 0.0367
Brugia malayi Pre-SET motif family protein 0.0029 0.0059 0.0066
Trypanosoma cruzi P-type H+-ATPase, putative 0.0049 0.0328 0.4246
Onchocerca volvulus Peroxidase homolog 0.0052 0.0365 0.1258
Echinococcus granulosus tumor protein p63 0.0328 0.398 0.4435
Onchocerca volvulus 0.0185 0.2111 0.768
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0193 0.0216
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0408
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0059 0.0041
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.0345
Leishmania major P-type H -ATPase, putative 0.0049 0.0328 0.4246
Trypanosoma cruzi P-type H+-ATPase, putative 0.0049 0.0328 0.4246
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0083 0.0773 0.0637
Toxoplasma gondii P-type ATPase4, putative 0.009 0.0855 0.0956
Onchocerca volvulus 0.0217 0.2531 0.9224
Brugia malayi hypothetical protein 0.0229 0.2689 0.3006
Leishmania major calcium-translocating P-type ATPase 0.0083 0.0773 1
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0365 0.1258
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0193 0.0191
Entamoeba histolytica hypothetical protein 0.0461 0.5729 0.6396
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0314 0.0351
Trichomonas vaginalis deoxyuridine 5'-triphosphate nucleotidohydrolase, putative 0.0706 0.8946 1
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0194 0.2221 0.2483
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0083 0.0773 0.0637
Schistosoma mansoni hypothetical protein 0.0039 0.0193 0.0191
Echinococcus granulosus geminin 0.0164 0.1836 0.2032
Brugia malayi dUTP diphosphatase 0.0706 0.8946 1
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0224 0.262 0.2603
Wolbachia endosymbiont of Brugia malayi dUTPase 0.0706 0.8946 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0348 0.0389
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0193 0.0216
Loa Loa (eye worm) hypothetical protein 0.0154 0.1695 0.1894
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.009 0.0855 0.0937
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.009 0.0855 0.26
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0083 0.0773 0.0845
Loa Loa (eye worm) hypothetical protein 0.0095 0.0932 0.1042
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0193 0.0191
Loa Loa (eye worm) hypothetical protein 0.0052 0.0365 0.0408
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0081 0.074 0.0804
Brugia malayi Peroxidasin 0.0052 0.0365 0.0408
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0365 0.0408
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.009 0.0855 0.0933
Chlamydia trachomatis deoxyuridine 5'-triphosphate nucleotidohydrolase 0.0706 0.8946 1
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0365 0.0408
Onchocerca volvulus Dual oxidase homolog 0.0052 0.0365 0.1258
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0193 0.0216
Brugia malayi hypoxia-induced factor 1 0.0146 0.1595 0.1783
Loa Loa (eye worm) hypothetical protein 0.0033 0.0113 0.0126
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0045 0.0025
Loa Loa (eye worm) calcium ATPase 0.0049 0.0321 0.0359
Echinococcus granulosus calcium transporting ATPase type 2C member 0.009 0.0855 0.0933
Echinococcus multilocularis nervana 2 0.0224 0.262 0.2603
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0365 0.0408
Onchocerca volvulus 0.0029 0.0059 0.0135
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0706 0.8946 1
Schistosoma mansoni patched 1 0.0041 0.0217 0.0218
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0083 0.0773 0.0637
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0083 0.0773 0.0752
Brugia malayi PAS domain containing protein 0.0047 0.0298 0.0333
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0022 0.0025
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0365 0.0408
Echinococcus multilocularis tumor protein p63 0.0328 0.398 0.3966
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.1595 0.1783
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0215 0.2498 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0018
Entamoeba histolytica hypothetical protein 0.0035 0.0137 0.0133
Mycobacterium tuberculosis Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase) 0.0245 0.2896 1
Schistosoma mansoni polycystin 1-related 0.0039 0.0193 0.0191
Brugia malayi hypothetical protein 0.0035 0.0137 0.0153
Brugia malayi hypothetical protein 0.0052 0.0365 0.0408
Treponema pallidum deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) 0.0706 0.8946 0.5
Schistosoma mansoni peroxidasin 0.0052 0.0365 0.0384
Plasmodium vivax calcium-transporting ATPase, putative 0.009 0.0855 0.0956

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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