Detailed information for compound 1841487

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 784.012 | Formula: C46H57NO8S
  • H donors: 0 H acceptors: 2 LogP: 9.3 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCC1(CO[C@@H]2O[C@@H]3CO[C@@H](O[C@@H]3[C@@H]([C@H]2OCc2ccccc2)OCc2ccccc2)c2ccccc2)CN1S(=O)(=O)c1ccc(cc1)C
  • InChi: 1S/C46H57NO8S/c1-3-4-5-6-7-8-18-29-46(33-47(46)56(48,49)39-27-25-35(2)26-28-39)34-53-45-43(51-31-37-21-14-10-15-22-37)42(50-30-36-19-12-9-13-20-36)41-40(54-45)32-52-44(55-41)38-23-16-11-17-24-38/h9-17,19-28,40-45H,3-8,18,29-34H2,1-2H3/t40-,41+,42+,43-,44+,45-,46?,47?/m1/s1
  • InChiKey: SJTUEAMUAZKESJ-XQUDWWQFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi EGF-like domain containing protein 0.0019 0.0049 0.0061
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0282 0.0335
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.1075 0.1264
Brugia malayi EGF-like domain containing protein 0.0019 0.0049 0.0061
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0122 0.133 0.1741
Loa Loa (eye worm) hypothetical protein 0.01 0.105 0.1374
Echinococcus multilocularis peroxidasin 0.0058 0.053 0.0528
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0064 0.0081
Onchocerca volvulus 0.002 0.0064 0.0377
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0185 0.0444
Entamoeba histolytica hypothetical protein 0.0076 0.0764 0.6893
Onchocerca volvulus Putative endochitinase 0.0086 0.0886 0.54
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Schistosoma mansoni notch 0.0019 0.0049 0.0055
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0117 0.1456
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.0367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0338 0.0441
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0064 0.0081
Schistosoma mansoni laminin gamma-3 chain 0.0019 0.0049 0.0055
Plasmodium vivax potassium channel, putative 0.0025 0.0123 0.063
Brugia malayi PAN domain containing protein 0.0037 0.0282 0.0367
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0173 0.1868
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0338 0.0441
Mycobacterium leprae Possible regulatory protein 0.0029 0.0173 0.2151
Onchocerca volvulus 0.0147 0.1638 1
Echinococcus granulosus slit 2 protein 0.0019 0.0049 0.0055
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0064 0.0062
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0064 0.0081
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0064 0.0073
Loa Loa (eye worm) hypothetical protein 0.0042 0.0338 0.0441
Schistosoma mansoni hypothetical protein 0.0019 0.0049 0.0055
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0093 0.0107
Echinococcus granulosus mitogen activated protein kinase 14 0.0138 0.1528 0.1798
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0338 0.0396
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0338 0.0396
Echinococcus granulosus neurogenic locus notch protein 4 0.0019 0.0049 0.0055
Loa Loa (eye worm) hypothetical protein 0.0053 0.0469 0.0612
Mycobacterium ulcerans putative regulatory protein 0.0046 0.0393 0.4885
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0173 0.1868
Brugia malayi nuclear hormone receptor 0.0042 0.0338 0.0441
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.0367
Onchocerca volvulus 0.0024 0.0117 0.07
Brugia malayi nuclear receptor NHR-67 0.002 0.0064 0.0081
Echinococcus multilocularis fibropellin Ia 0.0019 0.0049 0.0046
Onchocerca volvulus Putative cubilin 0.0019 0.0049 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0338 0.0441
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0282 0.0335
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0117 0.1456
Echinococcus granulosus protein jagged 1 0.0019 0.0049 0.0055
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.0367
Brugia malayi PAN domain containing protein 0.0037 0.0282 0.0367
Trichomonas vaginalis adenylate cyclase, putative 0.0029 0.0173 0.1868
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0117 0.1456
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.031 0.1879
Loa Loa (eye worm) blistered cuticle protein 3 0.0058 0.053 0.0692
Echinococcus multilocularis tumor protein p63 0.0348 0.4123 0.4122
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0064 0.0081
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0338 0.0396
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.1055 0.1381
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0064 0.0377
Brugia malayi Nuclear hormone receptor E75 0.002 0.0064 0.0081
Schistosoma mansoni peroxidasin 0.0058 0.053 0.0622
Onchocerca volvulus 0.0058 0.053 0.3226
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0002
Echinococcus multilocularis potassium large conductance calcium activated 0.0092 0.0961 0.0959
Echinococcus multilocularis aryl hydrocarbon receptor 0.0148 0.1644 0.1642
Entamoeba histolytica hypothetical protein 0.0076 0.0764 0.6893
Schistosoma mansoni hypothetical protein 0.0019 0.0049 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0119
Brugia malayi PAN domain containing protein 0.0037 0.0282 0.0367
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0136 0.0092
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0338 0.0441
Brugia malayi nuclear hormone receptor 0.002 0.0064 0.0081
Brugia malayi ecdysteroid receptor 0.0042 0.0338 0.0441
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0694 0.0907
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0338 0.0441
Onchocerca volvulus 0.0019 0.0049 0.0284
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0764 0.0762
Echinococcus granulosus potassium large conductance calcium activated 0.0092 0.0961 0.113
Trichomonas vaginalis conserved hypothetical protein 0.004 0.031 0.4003
Schistosoma mansoni hypothetical protein 0.0041 0.0331 0.0387
Onchocerca volvulus Putative endochitinase 0.0086 0.0886 0.54
Leishmania major hypothetical protein, conserved 0.0025 0.0123 0.0042
Onchocerca volvulus 0.0037 0.0282 0.171
Toxoplasma gondii PAN/Apple domain-containing protein 0.0037 0.0282 0.0335
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0136 0.0125
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0338 0.0396
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0029 0.0173 0.0396
Loa Loa (eye worm) animal heme peroxidase 0.0058 0.053 0.0692
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.1586 0.1867
Onchocerca volvulus Neurogenic locus notch homolog 0.0019 0.005 0.0294
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0019 0.0049 0.0061
Echinococcus granulosus neurogenic locus protein delta 0.0019 0.0049 0.0055
Brugia malayi nuclear receptor RXR 0.0022 0.0093 0.0119
Onchocerca volvulus Peroxidasin homolog 0.0058 0.053 0.3226
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0514 0.0604
Toxoplasma gondii microneme protein MIC4 0.0037 0.0282 0.0335
Echinococcus granulosus chromobox protein 1 0.0071 0.0694 0.0815
Brugia malayi Animal haem peroxidase family protein 0.0058 0.053 0.0692
Onchocerca volvulus 0.0019 0.0049 0.0284
Loa Loa (eye worm) hypothetical protein 0.0122 0.133 0.1741
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0138 0.1528 1
Brugia malayi hypothetical protein 0.0076 0.0764 0.0999
Brugia malayi endochitinase 0.0086 0.0886 0.1158
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.0692
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0136 0.0092
Echinococcus multilocularis mitogen activated protein kinase 14 0.0138 0.1528 0.1526
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.035 0.0347
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0064 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0338 0.0441
Onchocerca volvulus 0.002 0.0064 0.0377
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0514 0.0669
Onchocerca volvulus 0.0037 0.0282 0.171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0338 0.0441
Loa Loa (eye worm) hypothetical protein 0.0043 0.035 0.0456
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0144 0.1594 0.1877
Loa Loa (eye worm) hypothetical protein 0.0031 0.0204 0.0264
Loa Loa (eye worm) microfilarial chitinase 0.0075 0.0745 0.0974
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.008 0.0804 1
Echinococcus multilocularis chromobox protein 1 0.0071 0.0694 0.0692
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0338 0.0441
Echinococcus multilocularis protein jagged 1 0.0019 0.0049 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0122 0.133 0.1328
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0338 0.0336
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0514 0.2816
Brugia malayi hypothetical protein 0.0058 0.053 0.0692
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0136 0.073
Leishmania major protein kinase, putative 0.003 0.0185 0.0484
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.0757 0.089
Toxoplasma gondii hypothetical protein 0.0122 0.133 0.1841
Leishmania major calcium/potassium channel (CAKC), putative 0.0025 0.0123 0.0042
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0092 0.0954 0.0952
Schistosoma mansoni notch 0.0019 0.0049 0.0055
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Plasmodium falciparum potassium channel 0.0025 0.0123 0.063
Brugia malayi PAN domain containing protein 0.0037 0.0282 0.0367
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0338 0.0336
Mycobacterium ulcerans chitinase/cellulase 0.0066 0.0631 0.7848
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.0692
Loa Loa (eye worm) hypothetical protein 0.0042 0.0338 0.0441
Brugia malayi tailless protein 0.002 0.0064 0.0081
Loa Loa (eye worm) hypothetical protein 0.0042 0.0338 0.0441
Schistosoma mansoni coup transcription factor 0.0042 0.0338 0.0396
Brugia malayi EGF-like domain containing protein 0.0019 0.0049 0.0061
Echinococcus multilocularis calcium activated potassium channel 0.0093 0.0974 0.0971
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0338 0.0396
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0093 0.0091
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.008 0.0804 1
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.1055 0.1242
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0086 0.0881 0.1153
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0052
Brugia malayi small heat shock protein 0.0632 0.7626 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0136 0.0092
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0052
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0282 0.0367
Toxoplasma gondii ion channel protein 0.0025 0.0123 0.0106
Brugia malayi chromobox protein homolog 3 0.004 0.031 0.0403
Trypanosoma brucei protein kinase, putative 0.0056 0.0514 0.2786
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0122 0.133 0.1565
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Schistosoma mansoni hypothetical protein 0.0019 0.0049 0.0055
Echinococcus multilocularis neurogenic locus notch protein 0.0019 0.0049 0.0046
Leishmania major protein kinase, putative 0.003 0.0185 0.0484
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Onchocerca volvulus 0.0051 0.0449 0.2732
Toxoplasma gondii hypothetical protein 0.0037 0.0282 0.0335
Brugia malayi steroid hormone receptor 0.0042 0.0338 0.0441
Schistosoma mansoni chromobox protein 0.0071 0.0694 0.0815
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0064 0.0062
Schistosoma mansoni hypothetical protein 0.0075 0.0742 0.0872
Echinococcus granulosus aryl hydrocarbon receptor 0.0148 0.1644 0.1936
Loa Loa (eye worm) hypothetical protein 0.0026 0.0136 0.0175
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0514 0.2786
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0081
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0449 0.0527
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0029 0.0173 0.1868
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0029 0.0179 0.0177
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0338 0.0336
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.003 0.0185 0.0444
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Echinococcus granulosus fibropellin Ia 0.0019 0.0049 0.0055
Echinococcus granulosus neurogenic locus notch protein 0.0019 0.0049 0.0055
Schistosoma mansoni hypothetical protein 0.0019 0.0049 0.0055
Echinococcus granulosus single minded 2 0.0046 0.0393 0.046
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0081
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Loa Loa (eye worm) hypothetical protein 0.0025 0.0123 0.0158
Brugia malayi hypothetical protein 0.0029 0.0173 0.0223
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0117 0.015
Loa Loa (eye worm) cuticular endochitinase 0.0077 0.0771 0.1008
Brugia malayi hypothetical protein 0.002 0.0064 0.0081
Schistosoma mansoni calcium-activated potassium channel 0.0025 0.0123 0.0142
Schistosoma mansoni nuclear receptor 0.002 0.0064 0.0073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.003 0.0368
Brugia malayi PAS domain containing protein 0.0075 0.0746 0.0975
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0138 0.1528 1
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.008 0.0804 1
Brugia malayi Delta5 fatty acid desaturase 0.01 0.105 0.1374
Echinococcus multilocularis neurogenic locus protein delta 0.0019 0.0049 0.0046
Toxoplasma gondii microneme protein MIC17C 0.0037 0.0282 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0338 0.0441
Loa Loa (eye worm) hypothetical protein 0.0119 0.1284 0.1681
Brugia malayi PAN domain containing protein 0.0037 0.0282 0.0367
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0514 0.7195
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0108 0.1157 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0927 0.1213
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0093 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0166 0.1769
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0338 0.0396
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Schistosoma mansoni septate junction protein 0.0019 0.0049 0.0055
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.0692
Brugia malayi Death domain containing protein 0.0015 0.0002 0.000000013926
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0338 0.0441
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0081
Onchocerca volvulus 0.0037 0.0282 0.171
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.0367
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0002 0.000000012519
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0338 0.0336
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0081
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0338 0.0396
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0347 0.4584
Loa Loa (eye worm) hypothetical protein 0.0024 0.0117 0.015
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.0692
Brugia malayi PAN domain containing protein 0.0037 0.0282 0.0367
Echinococcus multilocularis neurogenic locus notch protein 4 0.0019 0.0049 0.0046
Schistosoma mansoni zinc finger protein 0.002 0.0064 0.0073
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0338 0.0396
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0338 0.0441
Loa Loa (eye worm) animal heme peroxidase 0.0058 0.053 0.0692
Brugia malayi EGF-like domain containing protein 0.0019 0.0049 0.0061
Onchocerca volvulus 0.0037 0.0282 0.171
Toxoplasma gondii PAN domain-containing protein 0.0582 0.7008 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0064 0.0081
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0061 0.0578 0.0755
Onchocerca volvulus 0.0019 0.0049 0.0284
Brugia malayi hypothetical protein 0.0022 0.0093 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0338 0.0441
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0117 0.015
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0081
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0029 0.0173 0.0356
Echinococcus granulosus protein jagged 1 0.0019 0.0049 0.0055
Loa Loa (eye worm) hypothetical protein 0.0042 0.0338 0.0441
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0694 1
Brugia malayi P38 map kinase family protein 2 0.0138 0.1528 0.2001
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0019 0.0049 0.0284
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0119
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.0692
Loa Loa (eye worm) hypothetical protein 0.0632 0.7626 1
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0064 0.0073
Brugia malayi Calcium binding EGF domain containing protein 0.0019 0.0049 0.0061
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0514 0.2816
Echinococcus granulosus peroxidasin 0.0058 0.053 0.0622
Trichomonas vaginalis conserved hypothetical protein 0.004 0.031 0.4003
Echinococcus multilocularis expressed conserved protein 0.0094 0.098 0.0978
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0138 0.1528 1
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0514 0.7195
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0514 0.7195
Brugia malayi Heterochromatin protein 1 0.0071 0.0694 0.0907
Schistosoma mansoni notch 0.0019 0.0049 0.0055
Brugia malayi hypothetical protein 0.0017 0.0024 0.0028
Brugia malayi Calcium binding EGF domain containing protein 0.0019 0.0049 0.0061
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0282 0.0367
Brugia malayi notch-like transmembrane receptor 0.0019 0.0049 0.0061
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0064 0.0073
Brugia malayi nuclear receptor NHR-88 0.0042 0.0338 0.0441
Onchocerca volvulus 0.0037 0.0282 0.171
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0338 0.0396
Brugia malayi EGF-like domain containing protein 0.0019 0.0049 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0338 0.0441
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.035 0.0456
Echinococcus granulosus microtubule associated protein 2 0.0701 0.8483 1
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0282 0.0367
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0064 0.0073
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0136 0.073
Onchocerca volvulus 0.0037 0.0282 0.171
Echinococcus granulosus chromobox protein 1 0.0071 0.0694 0.0815
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0029 0.0173 0.1868
Brugia malayi nuclear receptor RXR 0.002 0.0064 0.0081
Brugia malayi Cadherin domain containing protein 0.0019 0.0049 0.0061
Schistosoma mansoni retinoic acid receptor RXR 0.0144 0.1594 0.1877
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0002 0.00000001062
Onchocerca volvulus 0.0019 0.0049 0.0284
Plasmodium falciparum conserved protein, unknown function 0.0122 0.133 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.0692
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0338 0.0441
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Brugia malayi hypothetical protein 0.0022 0.0093 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0338 0.0441
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0338 0.0441
Brugia malayi Uncoordinated protein 44 0.0015 0.0002 0.000000013926
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0136 0.073
Brugia malayi Peroxidasin 0.0058 0.053 0.0692
Schistosoma mansoni cell polarity protein 0.0019 0.0049 0.0055
Leishmania major chitinase 0.0077 0.0771 0.4635
Schistosoma mansoni notch 0.0019 0.0049 0.0055
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0514 0.2786
Schistosoma mansoni notch 0.0019 0.0049 0.0055
Loa Loa (eye worm) hypothetical protein 0.0147 0.1638 0.2145
Onchocerca volvulus 0.0058 0.053 0.3226
Toxoplasma gondii microneme protein, putative 0.0037 0.0282 0.0335
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0282 0.0367
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0064 0.0073
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0029 0.0173 0.1868
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0514 0.2786
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0081
Echinococcus multilocularis mitogen activated protein kinase 11 0.0138 0.1528 0.1526
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0338 0.0396
Echinococcus multilocularis protein jagged 2 0.0019 0.0049 0.0046
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0004 0.0002
Echinococcus granulosus protein jagged 2 0.0019 0.0049 0.0055
Echinococcus multilocularis notch 0.0019 0.0049 0.0046
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0282 0.0335
Echinococcus granulosus tumor protein p63 0.0348 0.4123 0.4859
Loa Loa (eye worm) hypothetical protein 0.004 0.031 0.0403
Loa Loa (eye worm) animal heme peroxidase 0.0058 0.053 0.0692
Loa Loa (eye worm) hypothetical protein 0.0066 0.0631 0.0824
Echinococcus multilocularis chromobox protein 1 0.0071 0.0694 0.0692
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0029 0.0179 0.0209
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0514 0.2786
Echinococcus multilocularis protein patched 0.0043 0.035 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0173 0.1868
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0117 0.1456
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0119
Onchocerca volvulus 0.0031 0.0204 0.1231
Echinococcus multilocularis slit 2 protein 0.0019 0.0049 0.0046
Brugia malayi endochitinase 0.0077 0.0771 0.1008
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0064 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0338 0.0441
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.1586 0.1584
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0064 0.0073
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0338 0.0336
Schistosoma mansoni jun-related protein 0.0075 0.0742 0.0872
Brugia malayi conserved hypotetical protein 0.002 0.0064 0.0081
Loa Loa (eye worm) hypothetical protein 0.0024 0.0117 0.015
Brugia malayi Calcium binding EGF domain containing protein 0.0019 0.0049 0.0061
Onchocerca volvulus 0.0037 0.0282 0.171
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0081
Schistosoma mansoni hypothetical protein 0.0041 0.0331 0.0387
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.0692
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.003 0.0368
Echinococcus multilocularis transfer RNA-Lys 0.0046 0.0393 0.039
Onchocerca volvulus Putative endochitinase 0.0086 0.0886 0.54
Loa Loa (eye worm) hypothetical protein 0.0051 0.0449 0.0586
Brugia malayi ecdysone receptor 0.002 0.0064 0.0081
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0514 0.0512
Echinococcus granulosus jun protein 0.0092 0.0954 0.1122
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0764 0.0898
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0338 0.0396
Echinococcus multilocularis protein jagged 1 0.0019 0.0049 0.0046
Schistosoma mansoni hypothetical protein 0.0019 0.0049 0.0055
Echinococcus granulosus calcium activated potassium channel 0.0093 0.0974 0.1145
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.0692
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0514 0.0604
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.0692
Onchocerca volvulus 0.0042 0.0338 0.2054
Echinococcus multilocularis microtubule associated protein 2 0.0701 0.8483 0.8483
Schistosoma mansoni hypothetical protein 0.0041 0.0331 0.0387
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0117 0.1456
Echinococcus granulosus neural cadherin 0.0019 0.0049 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0338 0.0441
Toxoplasma gondii hypothetical protein 0.0037 0.0282 0.0335
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0093 0.0119
Onchocerca volvulus 0.0037 0.0282 0.171
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0514 0.0604
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0037 0.0282 0.0335
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0338 0.0441
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.0367
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0081
Onchocerca volvulus 0.0037 0.0282 0.171
Brugia malayi PAN domain containing protein 0.0037 0.0282 0.0367
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0052
Schistosoma mansoni hypothetical protein 0.0122 0.133 0.1565
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0119
Leishmania major hypothetical protein, conserved 0.0026 0.0136 0.0133
Brugia malayi PAN domain containing protein 0.0037 0.0282 0.0367
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0092 0.0954 0.1122
Loa Loa (eye worm) notch protein 0.0019 0.0049 0.0061
Schistosoma mansoni patched 1 0.0043 0.035 0.041
Onchocerca volvulus 0.0037 0.0282 0.171
Entamoeba histolytica hypothetical protein 0.0076 0.0764 0.6893
Schistosoma mansoni hypothetical protein 0.0019 0.0049 0.0055
Brugia malayi hypothetical protein 0.002 0.0064 0.0081
Loa Loa (eye worm) DR-78 0.002 0.0064 0.0081
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0117 0.1456
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0064 0.0377
Brugia malayi Animal haem peroxidase family protein 0.0058 0.053 0.0692
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0029 0.0179 0.0232
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0514 0.2786
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.0692
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0093 0.0119
Schistosoma mansoni fatty acid desaturase 0.01 0.1054 0.124
Schistosoma mansoni peroxidasin 0.0058 0.053 0.0622
Toxoplasma gondii PAN domain-containing protein 0.0582 0.7008 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Loa Loa (eye worm) hypothetical protein 0.0022 0.0093 0.0119
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0064 0.0081
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.0367
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0117 0.015
Entamoeba histolytica chitinase, putative 0.0077 0.0771 0.6967
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0029 0.0173 0.1868
Brugia malayi Cadherin domain containing protein 0.0019 0.0049 0.0061
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.003 0.0185 0.0444
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0338 0.0396
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0064 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.035 0.4629
Loa Loa (eye worm) hypothetical protein 0.0042 0.0338 0.0441
Loa Loa (eye worm) hypothetical protein 0.0061 0.0578 0.0755
Schistosoma mansoni single-minded 0.0075 0.0746 0.0877
Onchocerca volvulus Slit protein homolog 0.0019 0.0049 0.0284
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0138 0.1528 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0121 0.132 0.1318
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.0757 0.0755
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0119 0.1284 0.1681
Brugia malayi CHE-14 protein 0.0043 0.035 0.0456
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Onchocerca volvulus 0.0072 0.0711 0.4331
Loa Loa (eye worm) hypothetical protein 0.0037 0.0282 0.0367
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.0692
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0117 0.1456
Schistosoma mansoni hypothetical protein 0.0076 0.0764 0.0898
Loa Loa (eye worm) hypothetical protein 0.0029 0.0173 0.0223
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0338 0.0396
Schistosoma mansoni slit 0.0019 0.0049 0.0055
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0338 0.0441
Echinococcus granulosus calcium activated potassium channel variant 0.0086 0.0881 0.1036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.1055 1
Toxoplasma gondii microneme protein MIC17B 0.0037 0.0282 0.0335
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0052
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0019 0.0053 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0514 0.0671
Loa Loa (eye worm) hypothetical protein 0.0042 0.0338 0.0441
Brugia malayi Nuclear hormone receptor E75 0.002 0.0064 0.0081
Mycobacterium ulcerans hypothetical protein 0.0024 0.0117 0.1456
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0764 0.0898
Brugia malayi Delta serrate ligand family protein 0.0019 0.0049 0.0061
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0514 0.0512
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0338 0.2054
Echinococcus granulosus Protein patched homolog 1 0.0043 0.035 0.041
Onchocerca volvulus 0.0122 0.133 0.8117
Echinococcus multilocularis mitogen activated protein kinase 11 0.0138 0.1528 0.1526
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.0692
Schistosoma mansoni nuclear hormone receptor 0.002 0.0064 0.0073
Toxoplasma gondii ion channel protein 0.0025 0.0123 0.0106
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.0692
Schistosoma mansoni notch 0.0019 0.005 0.0057
Onchocerca volvulus Peroxidase homolog 0.0058 0.053 0.3226
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0081
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.035 0.041
Loa Loa (eye worm) hypothetical protein 0.0042 0.0338 0.0441
Toxoplasma gondii subtilisin SUB12 0.0037 0.0282 0.0335
Brugia malayi bHLH-PAS transcription factor 0.0046 0.0393 0.0512
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0338 0.0396
Brugia malayi Muscle positioning protein 4 0.0019 0.0049 0.0061
Echinococcus granulosus notch 0.0019 0.0049 0.0055
Echinococcus multilocularis jun protein 0.0092 0.0954 0.0952
Brugia malayi Protein kinase domain containing protein 0.0016 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0117 0.015
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0338 0.0441
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0117 0.1456
Loa Loa (eye worm) hypothetical protein 0.0089 0.0923 0.1208
Brugia malayi hypothetical protein 0.0072 0.0711 0.0929
Echinococcus multilocularis neurogenic locus protein delta 0.0019 0.0049 0.0046
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0514 0.7195
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Loa Loa (eye worm) chitinase I 0.0077 0.0771 0.1008
Schistosoma mansoni hypothetical protein 0.0041 0.0331 0.0387
Onchocerca volvulus 0.0037 0.0282 0.171
Brugia malayi bZIP transcription factor family protein 0.0092 0.0954 0.1249
Brugia malayi EGF-like domain containing protein 0.0019 0.0049 0.0061
Schistosoma mansoni aryl hydrocarbon receptor 0.0194 0.2218 0.2612
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0081
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0052
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0064 0.0062
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0338 0.0336
Onchocerca volvulus 0.0122 0.133 0.8117
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0347 0.2106
Plasmodium vivax hypothetical protein, conserved 0.0122 0.133 1
Mycobacterium ulcerans chitinase/cellulase 0.0066 0.0631 0.7848
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0338 0.0441
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.003 0.0368
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0694 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0338 0.0336
Brugia malayi Endochitinase 0.0086 0.0886 0.1158
Onchocerca volvulus Chorion peroxidase homolog 0.0058 0.053 0.3226
Toxoplasma gondii microneme protein MIC17A 0.0037 0.0282 0.0335
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0185 0.0444
Onchocerca volvulus Putative endochitinase 0.0077 0.0771 0.4698
Toxoplasma gondii PAN domain-containing protein 0.0037 0.0282 0.0335
Echinococcus multilocularis mitogen activated protein kinase 14 0.0138 0.1528 0.1526
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0002 0.000000012519
Brugia malayi MAP kinase sur-1 0.0056 0.0514 0.0671
Schistosoma mansoni hypothetical protein 0.0019 0.0049 0.0055
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0514 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0064 0.0073
Brugia malayi PAN domain containing protein 0.0037 0.0282 0.0367
Brugia malayi PAN domain containing protein 0.0037 0.0282 0.0367
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.003 0.0368
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0117 0.1456
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0166 0.1769
Entamoeba histolytica hypothetical protein 0.0076 0.0764 0.6893
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0064 0.0073
Schistosoma mansoni chromobox protein 0.0071 0.0694 0.0815
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0117 0.1456
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0338 0.0441
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Loa Loa (eye worm) PAN domain-containing protein 0.0037 0.0282 0.0367
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0042 0.052
Brugia malayi Animal haem peroxidase family protein 0.0058 0.053 0.0692
Brugia malayi EGF-like domain containing protein 0.0019 0.0049 0.0061
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0064 0.0081
Echinococcus multilocularis fat cadherin tumor suppressor 0.0019 0.0049 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0064 0.0062
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0019 0.0049 0.0055
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0081
Echinococcus granulosus delta-like protein 1 0.0019 0.0049 0.0055
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0338 0.0396
Echinococcus granulosus expressed conserved protein 0.0094 0.098 0.1153
Loa Loa (eye worm) animal heme peroxidase 0.0058 0.053 0.0692
Loa Loa (eye worm) hypothetical protein 0.0122 0.133 0.1741
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0042 0.052
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0338 0.0396
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0338 0.0441
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0081
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.1055 0.1053
Brugia malayi hypothetical protein 0.0026 0.0136 0.0175
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0093 0.0107
Echinococcus granulosus Ankyrin 0.0015 0.0004 0.0002
Schistosoma mansoni microtubule-associated protein tau 0.0701 0.8483 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0029 0.0173 0.0356
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0338 0.0396
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0064 0.0073
Loa Loa (eye worm) hypothetical protein 0.0042 0.0338 0.0441
Leishmania major delta-5 fatty acid desaturase 0.01 0.105 0.6614
Onchocerca volvulus 0.0058 0.053 0.3226
Brugia malayi Animal haem peroxidase family protein 0.0058 0.053 0.0692
Onchocerca volvulus Peroxidasin homolog 0.0058 0.053 0.3226
Trichomonas vaginalis guanylate cyclase, putative 0.0029 0.0173 0.1868
Echinococcus multilocularis neural cadherin 0.0019 0.0049 0.0046
Brugia malayi Animal haem peroxidase family protein 0.0058 0.053 0.0692
Echinococcus multilocularis calcium activated potassium channel variant 0.0086 0.0881 0.0879
Loa Loa (eye worm) hypothetical protein 0.0119 0.1291 0.169
Schistosoma mansoni calcium-activated potassium channel 0.0086 0.0881 0.1036
Onchocerca volvulus 0.0047 0.0399 0.2426
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0338 0.2054
Onchocerca volvulus Putative endochitinase 0.0077 0.0771 0.4698
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.008 0.0804 1
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0338 0.0336
Onchocerca volvulus Dual oxidase homolog 0.0058 0.053 0.3226
Echinococcus granulosus protein jagged 2 0.0019 0.0049 0.0055
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0347 0.4584
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0338 0.2054
Echinococcus multilocularis protein dispatched 1 0.0049 0.0425 0.0422
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0338 0.0396
Echinococcus multilocularis neurogenic locus notch protein 0.0019 0.0049 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0138 0.1528 0.2001
Trichomonas vaginalis guanylate cyclase, putative 0.0029 0.0173 0.1868
Loa Loa (eye worm) hypothetical protein 0.0058 0.053 0.0692
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0338 0.0396
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0093 0.0119
Schistosoma mansoni nuclear receptor 0.002 0.0064 0.0073
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0117 0.1456
Brugia malayi Blistered cuticle protein 3 0.0058 0.053 0.0692
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.0061 0.0578 0.0755
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0029 0.0173 0.1868
Loa Loa (eye worm) hypothetical protein 0.01 0.1055 0.1381
Echinococcus multilocularis Ankyrin 0.0015 0.0004 0.0002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0338 0.0336
Brugia malayi GCC2 and GCC3 family protein 0.0019 0.0049 0.0061
Echinococcus granulosus neurogenic locus notch protein 0.0019 0.0049 0.0055
Loa Loa (eye worm) Notch2 0.0019 0.0049 0.0061
Echinococcus granulosus mitogen activated protein kinase 11 0.0138 0.1528 0.1798
Onchocerca volvulus 0.0019 0.0049 0.0284
Schistosoma mansoni calcium-activated potassium channel 0.0092 0.0961 0.113
Loa Loa (eye worm) FAT-3 protein 0.01 0.105 0.1374
Onchocerca volvulus Peroxidase homolog 0.0058 0.053 0.3226
Onchocerca volvulus 0.01 0.1054 0.643
Mycobacterium tuberculosis Possible chitinase 0.0066 0.0631 0.7848
Loa Loa (eye worm) hypothetical protein 0.0019 0.0049 0.0061

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 154 uM Cytotoxicity against human A549 cells after 48 hrs by MTT assay ChEMBL. 24177365

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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