Detailed information for compound 1846977

Basic information

Technical information
  • TDR Targets ID: 1846977
  • Name: 4-[1-(4-chlorophenyl)-2-nitroethyl]-5-methyl- 2-phenyl-1H-pyrazol-3-one
  • MW: 357.791 | Formula: C18H16ClN3O3
  • H donors: 1 H acceptors: 3 LogP: 4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=N(=O)CC(c1c(C)[nH]n(c1=O)c1ccccc1)c1ccc(cc1)Cl
  • InChi: 1S/C18H16ClN3O3/c1-12-17(18(23)22(20-12)15-5-3-2-4-6-15)16(11-21(24)25)13-7-9-14(19)10-8-13/h2-10,16,20H,11H2,1H3
  • InChiKey: RECNITXDQPJVBJ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 4-[1-(4-chlorophenyl)-2-nitro-ethyl]-5-methyl-2-phenyl-1H-pyrazol-3-one
  • AP-906/41650532
  • T5466513
  • MLS000697107
  • SMR000237847

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens Wolf-Hirschhorn syndrome candidate 1 Starlite/ChEMBL No references
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Treponema pallidum recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis histone lysine N methyltransferase NSD3 Get druggable targets OG5_130029 All targets in OG5_130029
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_130029 All targets in OG5_130029
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Wolbachia endosymbiont of Brugia malayi recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Mycobacterium ulcerans replicative DNA helicase DnaB Get druggable targets OG5_131890 All targets in OG5_131890
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum expressed protein Get druggable targets OG5_130029 All targets in OG5_130029
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Chlamydia trachomatis recombinase RecA Get druggable targets OG5_130095 All targets in OG5_130095
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Histone-lysine N-methyltransferase NSD3, putative Get druggable targets OG5_130029 All targets in OG5_130029
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Schistosoma mansoni Replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Treponema pallidum replicative DNA helicase (dnaB) Get druggable targets OG5_131890 All targets in OG5_131890
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum protein with 4 PHD domains plus a SET domain and associated cysteine cluster at the C-terminus Get druggable targets OG5_130029 All targets in OG5_130029
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB Get druggable targets OG5_131890 All targets in OG5_131890
Echinococcus granulosus histone lysine N methyltransferase NSD3 Get druggable targets OG5_130029 All targets in OG5_130029
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans recombinase A Get druggable targets OG5_130095 All targets in OG5_130095
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. Get druggable targets OG5_130095 All targets in OG5_130095
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni SET domain protein Get druggable targets OG5_130029 All targets in OG5_130029
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K05302 histone-lysine N-methyltransferase [EC2.1.1.43], putative Get druggable targets OG5_130029 All targets in OG5_130029
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. Get druggable targets OG5_130095 All targets in OG5_130095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Chlamydia trachomatis replicative DNA helicase Get druggable targets OG5_131890 All targets in OG5_131890
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0349 0.3254
Loa Loa (eye worm) PAN domain-containing protein 0.0141 0.0273 0.4343
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0064 0.0414
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0206 0.2277
Loa Loa (eye worm) hypothetical protein 0.0141 0.0273 0.4343
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.021 0.0173
Plasmodium falciparum glutathione reductase 0.0046 0.0037 0.5
Trypanosoma brucei glucosidase, putative 0.0044 0.0032 0.0479
Brugia malayi PAN domain containing protein 0.0141 0.0273 0.4343
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0409 0.2071
Trypanosoma brucei polo-like protein kinase 0.0114 0.0206 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.1976 1
Toxoplasma gondii PAN domain-containing protein 0.0141 0.0273 0.0454
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0106 0.0983
Loa Loa (eye worm) PAN domain-containing protein 0.0141 0.0273 0.4343
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.01 0.0505
Toxoplasma gondii PAN domain-containing protein 0.2194 0.5327 1
Echinococcus multilocularis lamin dm0 0.0033 0.0005 0.0026
Schistosoma mansoni hypothetical protein 0.0058 0.0068 0.0346
Trypanosoma brucei trypanothione reductase 0.0046 0.0037 0.0753
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0794 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.0273 0.4343
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.01 0.0505
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.1976 1
Brugia malayi jmjC domain containing protein 0.0071 0.01 0.159
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0032 0.0517
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0182 0.0145
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0206 0.1041
Loa Loa (eye worm) glutathione reductase 0.0046 0.0037 0.0597
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.0794 1
Brugia malayi jmjC domain containing protein 0.0071 0.01 0.159
Onchocerca volvulus 0.0141 0.0273 1
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.01 0.0505
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.1976 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0032 0.0164
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0106 0.0983
Brugia malayi hypothetical protein 0.0286 0.0628 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0206 0.2277
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0349 0.0313
Brugia malayi glutathione reductase 0.0046 0.0037 0.0597
Toxoplasma gondii microneme protein MIC17C 0.0141 0.0273 0.0454
Toxoplasma gondii subtilisin SUB12 0.0141 0.0273 0.0454
Schistosoma mansoni SET domain protein 0.004 0.0022 0.0113
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0106 0.0534
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0037 0.5
Onchocerca volvulus 0.0141 0.0273 1
Toxoplasma gondii PAN/Apple domain-containing protein 0.0141 0.0273 0.0454
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0794 1
Toxoplasma gondii microneme protein, putative 0.0141 0.0273 0.0454
Loa Loa (eye worm) hypothetical protein 0.0141 0.0273 0.4343
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0794 1
Schistosoma mansoni lamin 0.0033 0.0005 0.0026
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0106 0.0138
Brugia malayi PAN domain containing protein 0.0141 0.0273 0.4343
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0206 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0005 0.0082
Toxoplasma gondii hypothetical protein 0.0141 0.0273 0.0454
Brugia malayi intermediate filament protein 0.0033 0.0005 0.0082
Loa Loa (eye worm) hypothetical protein 0.0286 0.0628 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.0206 0.2277
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0794 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.01 0.159
Schistosoma mansoni alpha-glucosidase 0.0169 0.0342 0.173
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0206 0.2277
Toxoplasma gondii microneme protein MIC17B 0.0141 0.0273 0.0454
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.0206 0.3277
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0206 0.2277
Onchocerca volvulus 0.0141 0.0273 1
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.004 0.0022 0.0113
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0349 0.0536
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0106 0.0534
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.0206 0.3277
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0794 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.021 0.0173
Plasmodium vivax glutathione reductase, putative 0.0046 0.0037 0.5
Schistosoma mansoni survival motor neuron protein 0.0058 0.0068 0.0346
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0409 0.2071
Mycobacterium ulcerans recombinase A 0.013 0.0246 0.2289
Brugia malayi PAN domain containing protein 0.0141 0.0273 0.4343
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3756 0.9172 0.9169
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0106 0.0068
Toxoplasma gondii thioredoxin reductase 0.0046 0.0037 0.0009
Mycobacterium tuberculosis Probable reductase 0.0104 0.0182 0.0145
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0794 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0106 0.4213
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0106 0.0534
Brugia malayi PAN domain containing protein 0.0141 0.0273 0.4343
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.0409 0.6518
Loa Loa (eye worm) PAN domain-containing protein 0.0141 0.0273 0.4343
Onchocerca volvulus 0.0141 0.0273 1
Onchocerca volvulus 0.0141 0.0273 1
Brugia malayi PAN domain containing protein 0.0141 0.0273 0.4343
Echinococcus granulosus intermediate filament protein 0.0033 0.0005 0.0026
Onchocerca volvulus 0.0141 0.0273 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0039 0.0197
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0794 1
Brugia malayi PAN domain containing protein 0.0141 0.0273 0.4343
Mycobacterium leprae Conserved hypothetical protein 0.1376 0.3312 1
Toxoplasma gondii hypothetical protein 0.0141 0.0273 0.0454
Onchocerca volvulus 0.0141 0.0273 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.021 0.0091
Schistosoma mansoni kinase 0.0058 0.0068 0.0343
Echinococcus granulosus lamin dm0 0.0033 0.0005 0.0026
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0182 0.0145
Onchocerca volvulus 0.0141 0.0273 1
Echinococcus granulosus geminin 0.0205 0.0429 0.2169
Onchocerca volvulus 0.0033 0.0005 0.019
Loa Loa (eye worm) PAN domain-containing protein 0.0141 0.0273 0.4343
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.0409 0.2071
Schistosoma mansoni hypothetical protein 0.0205 0.0429 0.2169
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0037 0.0753
Brugia malayi PAN domain containing protein 0.0141 0.0273 0.4343
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0628 0.3177
Brugia malayi Thioredoxin reductase 0.0046 0.0037 0.0597
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.01 0.0505
Onchocerca volvulus 0.0141 0.0273 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.01 0.0505
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0032 0.0479
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.0794 0.6619
Plasmodium falciparum thioredoxin reductase 0.0046 0.0037 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0068 0.1089
Echinococcus multilocularis lamin 0.0033 0.0005 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0206 0.2277
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.0206 0.7547
Loa Loa (eye worm) hypothetical protein 0.0033 0.0005 0.0082
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.0206 1
Brugia malayi PAN domain containing protein 0.0141 0.0273 0.4343
Loa Loa (eye worm) PAN domain-containing protein 0.0141 0.0273 0.4343
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0467 0.1074 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0794 1
Toxoplasma gondii microneme protein MIC4 0.0141 0.0273 0.0454
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0032 0.0164
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.0206 1
Echinococcus granulosus lamin 0.0033 0.0005 0.0026
Loa Loa (eye worm) hypothetical protein 0.0032 0.0004 0.0059
Loa Loa (eye worm) twinkle helicase 0.0133 0.0253 0.4033
Brugia malayi PAN domain containing protein 0.0141 0.0273 0.4343
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0467 0.1074 1
Schistosoma mansoni Replicative DNA helicase 0.0467 0.1074 0.5433
Chlamydia trachomatis replicative DNA helicase 0.0467 0.1074 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0106 0.0534
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0037 0.0597
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0182 0.0145
Schistosoma mansoni intermediate filament proteins 0.0033 0.0005 0.0026
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0628 0.3177
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0141 0.0273 0.0454
Echinococcus multilocularis geminin 0.0205 0.0429 0.2169
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.0409 0.6518
Echinococcus multilocularis musashi 0.0033 0.0005 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0794 1
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.013 0.0246 0.0205
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0182 0.0145
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0206 0.2277
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0182 0.0145
Toxoplasma gondii PAN domain-containing protein 0.0141 0.0273 0.0454
Schistosoma mansoni jumonji domain containing protein 0.0071 0.01 0.0505
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.0206 0.1041
Toxoplasma gondii microneme protein MIC17A 0.0141 0.0273 0.0454
Schistosoma mansoni hypothetical protein 0.0205 0.0429 0.2169
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0064 0.0414
Toxoplasma gondii PAN domain-containing protein 0.0141 0.0273 0.0454
Loa Loa (eye worm) hypothetical protein 0.0141 0.0273 0.4343
Toxoplasma gondii PAN domain-containing protein 0.0141 0.0273 0.0454
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0005 0.0082
Loa Loa (eye worm) hypothetical protein 0.0141 0.0273 0.4343
Schistosoma mansoni alpha-glucosidase 0.0169 0.0342 0.173
Schistosoma mansoni lamin 0.0033 0.0005 0.0026
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0794 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.0206 0.2277
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0005 0.0082
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0032 0.0517
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0467 0.1074 0.285
Onchocerca volvulus 0.0141 0.0273 1
Onchocerca volvulus 0.0033 0.0005 0.019
Brugia malayi PAN domain containing protein 0.0141 0.0273 0.4343
Loa Loa (eye worm) hypothetical protein 0.0141 0.0273 0.4343
Onchocerca volvulus 0.0058 0.0068 0.2508
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.021 0.0173
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.004 0.0022 0.0113
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.0206 0.1041
Onchocerca volvulus 0.0141 0.0273 1
Leishmania major trypanothione reductase 0.0046 0.0037 0.0287
Toxoplasma gondii PAN domain-containing protein 0.2194 0.5327 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0106 0.0983
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0039 0.0197
Schistosoma mansoni alpha glucosidase 0.0044 0.0032 0.0164
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.01 0.0505
Loa Loa (eye worm) hypothetical protein 0.0141 0.0273 0.4343
Treponema pallidum replicative DNA helicase (dnaB) 0.0467 0.1074 1
Onchocerca volvulus 0.0114 0.0205 0.7522
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0032 0.0479

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 5.32 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
AC50 (functional) = 8.619 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
AC50 (binding) 9.52 uM PubChem BioAssay. Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) = 3.22 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2097, AID2223, AID489010, AID492950] ChEMBL. No reference
Potency (functional) = 0.02 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 1.7783 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (binding) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 9.9237 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.9173 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5594 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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