Detailed information for compound 1850534

Basic information

Technical information
  • TDR Targets ID: 1850534
  • Name: 9-[(1S,8R,10R)-3,5-dihydroxy-3,5-dioxo-2,4,6, 9-tetraoxa-3$l^{5},5$l^{5}-diphosphabicyclo[6 .3.0]undecan-10-yl]-N-methylpurin-6-amine
  • MW: 407.213 | Formula: C11H15N5O8P2
  • H donors: 3 H acceptors: 7 LogP: -2.01 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1ncnc2c1ncn2[C@@H]1O[C@H]2[C@H](C1)OP(=O)(O)OP(=O)(OC2)O
  • InChi: 1S/C11H15N5O8P2/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6-7(22-8)3-21-25(17,18)24-26(19,20)23-6/h4-8H,2-3H2,1H3,(H,17,18)(H,19,20)(H,12,13,14)/t6-,7+,8+/m0/s1
  • InChiKey: XVNJOKAIOBBAFT-XLPZGREQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-[(1S,8R,10R)-3,5-dihydroxy-3,5-dioxo-2,4,6,9-tetraoxa-3$l^{5},5$l^{5}-diphosphabicyclo[6.3.0]undecan-10-yl]-N-methyl-purin-6-amine
  • 9-[(1S,8R,10R)-3,5-dihydroxy-3,5-dioxo-2,4,6,9-tetraoxa-3$l^{5},5$l^{5}-diphosphabicyclo[6.3.0]undecan-10-yl]-N-methyl-6-purinamine
  • [9-[(1S,8R,10R)-3,5-dihydroxy-3,5-diketo-2,4,6,9-tetraoxa-3$l^{5},5$l^{5}-diphosphabicyclo[6.3.0]undecan-10-yl]purin-6-yl]-methyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Voltage-dependent L-type calcium channel beta-2 subunit 0.002 0.0003 0.0003
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0023 0.0007 0.1203
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Echinococcus granulosus Zinc finger RanBP2 type 0.0045 0.0031 0.0028
Toxoplasma gondii aspartyl protease ASP1 0.0346 0.0358 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.0007 0.1203
Onchocerca volvulus 0.0154 0.0149 0.3245
Toxoplasma gondii beta tubulin 0.0066 0.0054 0.1422
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0154 0.0149 0.0146
Schistosoma mansoni biogenic amine (5HT) receptor 0.0154 0.0149 0.0146
Schistosoma mansoni tubulin subunit beta 0.0066 0.0054 0.0051
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0045 0.0031 0.0031
Brugia malayi Tachykinin-like peptides receptor 99D 0.0154 0.0149 0.0149
Schistosoma mansoni tubulin subunit beta 0.0066 0.0054 0.0051
Echinococcus granulosus g protein coupled receptor 0.0154 0.0149 0.0146
Brugia malayi hypothetical protein 0.0154 0.0149 0.0149
Trypanosoma brucei hypothetical protein, conserved 0.0045 0.0031 0.1389
Plasmodium vivax aspartyl protease, putative 0.0082 0.0071 0.1966
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Brugia malayi hypothetical protein 0.0154 0.0149 0.0149
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0023 0.0007 1
Echinococcus multilocularis MAGUK p55 subfamily 0.0024 0.0007 0.0004
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0045 0.0031 0.5471
Onchocerca volvulus 0.0154 0.0149 0.3245
Loa Loa (eye worm) hypothetical protein 0.0041 0.0026 0.0026
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0377 0.0391 0.0391
Entamoeba histolytica tubulin family protein 0.0066 0.0054 1
Echinococcus multilocularis CD36 class B scavenger receptor 0.0041 0.0026 0.0023
Mycobacterium tuberculosis Probable guanylate kinase Gmk 0.002 0.0003 0.0529
Echinococcus granulosus biogenic amine 5HT receptor 0.0154 0.0149 0.0146
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0023 0.0007 0.0181
Brugia malayi Peripheral plasma membrane protein CASK 0.0024 0.0007 0.0007
Plasmodium falciparum plasmepsin VI 0.0346 0.0358 1
Schistosoma mansoni amine GPCR 0.0154 0.0149 0.0146
Brugia malayi brahma associated protein 60 kDa 0.0128 0.012 0.012
Loa Loa (eye worm) guanylate kinase 0.002 0.0003 0.0003
Echinococcus granulosus SWI:SNF matrix associated 0.0128 0.012 0.0117
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0346 0.0358 1
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0128 0.012 0.0117
Echinococcus multilocularis zinc finger protein Ran binding 0.0045 0.0031 0.0028
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0154 0.0149 0.0146
Echinococcus granulosus G protein coupled receptor 139 0.0154 0.0149 0.0146
Plasmodium falciparum plasmepsin IV 0.0346 0.0358 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0023 0.0007 0.0712
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0154 0.0149 0.0146
Leishmania major hypothetical protein, conserved 0.0045 0.0031 0.5471
Echinococcus granulosus thioredoxin glutathione reductase 0.0067 0.0054 0.0051
Schistosoma mansoni tubulin subunit beta 0.0066 0.0054 0.0051
Schistosoma mansoni neuropeptide F-like receptor 0.0154 0.0149 0.0146
Schistosoma mansoni brg-1 associated factor 0.0128 0.012 0.0117
Plasmodium falciparum plasmepsin X 0.0082 0.0071 0.1966
Loa Loa (eye worm) hypothetical protein 0.0041 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0053 0.0039 0.0039
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0023 0.0007 0.0181
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0007 0.9735
Trypanosoma brucei trypanothione reductase 0.0067 0.0054 0.2538
Plasmodium vivax thioredoxin reductase, putative 0.0067 0.0054 0.1505
Schistosoma mansoni cathepsin D (A01 family) 0.1022 0.1092 0.1089
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0712
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0045 0.0031 0.0786
Echinococcus multilocularis serotonin receptor 0.0154 0.0149 0.0146
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.9216 1 1
Echinococcus multilocularis membrane associated guanylate kinase ww and pdz 0.005 0.0036 0.0033
Loa Loa (eye worm) neuropeptide F receptor 0.0154 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0082 0.0071 0.0068
Brugia malayi glutathione reductase 0.0067 0.0054 0.0054
Schistosoma mansoni opsin-like receptor 0.0154 0.0149 0.0146
Plasmodium vivax guanylate kinase, putative 0.002 0.0003 0.008
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0007 0.9735
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0054 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0031 0.5471
Schistosoma mansoni neuropeptide receptor 0.0154 0.0149 0.0146
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0154 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0154 0.0149 0.0146
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0023 0.0007 0.1203
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Echinococcus granulosus MAGUK p55 subfamily 0.0024 0.0007 0.0004
Echinococcus granulosus serotonin receptor 0.0154 0.0149 0.0146
Echinococcus multilocularis tubulin subunit beta 0.0066 0.0054 0.0051
Loa Loa (eye worm) hypothetical protein 0.0041 0.0026 0.0026
Echinococcus granulosus neuropeptide FF receptor 2 0.0154 0.0149 0.0146
Brugia malayi ephrin receptor 1 precursor 0.0025 0.0009 0.0009
Echinococcus multilocularis tubulin beta 1 chain 0.0066 0.0054 0.0051
Brugia malayi Tubulin beta-1 chain 0.0066 0.0054 0.0054
Echinococcus granulosus CD36 class B scavenger receptor 0.0041 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.007
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0154 0.0149 0.0146
Trypanosoma cruzi WLM domain containing protein, putative 0.0045 0.0031 0.5471
Brugia malayi hypothetical protein 0.0041 0.0026 0.0026
Echinococcus multilocularis neuropeptides capa receptor 0.0154 0.0149 0.0146
Giardia lamblia Beta tubulin 0.0066 0.0054 1
Schistosoma mansoni opsin-like receptor 0.0154 0.0149 0.0146
Brugia malayi GnHR receptor homolog 0.5623 0.6094 0.6094
Brugia malayi PDZ domain containing protein 0.0051 0.0037 0.0037
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0712
Trichomonas vaginalis tubulin alpha chain, putative 0.0066 0.0054 0.1422
Brugia malayi G-protein coupled receptor 0.0154 0.0149 0.0149
Onchocerca volvulus 0.0427 0.0446 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.0041 0.0026 0.0023
Echinococcus multilocularis MAGUK p55 subfamily 0.0024 0.0007 0.0004
Echinococcus multilocularis CD36 class B scavenger receptor 0.0041 0.0026 0.0023
Echinococcus multilocularis neuropeptides capa receptor 0.0154 0.0149 0.0146
Brugia malayi ORL1-like opioid receptor 0.0154 0.0149 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.012 0.3307
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0154 0.0149 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0712
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Echinococcus granulosus rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Trichomonas vaginalis mercuric reductase, putative 0.0023 0.0007 0.0102
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0154 0.0149 0.0149
Plasmodium falciparum guanylate kinase 0.002 0.0003 0.008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0149 0.0146
Schistosoma mansoni neuropeptide F-like receptor 0.0154 0.0149 0.0146
Echinococcus granulosus neuropeptide Y receptor 0.0154 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Plasmodium falciparum plasmepsin VIII, putative 0.0082 0.0071 0.1966
Brugia malayi guanylate kinase 0.002 0.0003 0.0003
Plasmodium vivax aspartyl proteinase, putative 0.0082 0.0071 0.1966
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Brugia malayi Guanylate kinase family protein 0.0024 0.0007 0.0007
Schistosoma mansoni growth hormone secretagogue receptor 0.0154 0.0149 0.0146
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0346 0.0358 0.0355
Echinococcus multilocularis SWI:SNF matrix associated 0.0128 0.012 0.0117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0149 0.0146
Schistosoma mansoni amine GPCR 0.0154 0.0149 0.0146
Loa Loa (eye worm) thioredoxin reductase 0.0067 0.0054 0.0054
Echinococcus multilocularis allatostatin A receptor 0.0427 0.0446 0.0443
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.007 0.0058 0.0055
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0154 0.0149 0.0146
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Schistosoma mansoni neuropeptide receptor 0.0154 0.0149 0.0146
Echinococcus granulosus tm gpcr rhodopsin 0.0154 0.0149 0.0146
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0128 0.012 0.0117
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Brugia malayi Serotonin receptor 0.0154 0.0149 0.0149
Trypanosoma brucei beta tubulin 0.0066 0.0054 0.2511
Brugia malayi larval opioid receptor 0.0154 0.0149 0.0149
Toxoplasma gondii aspartyl protease ASP3 0.0082 0.0071 0.1902
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Schistosoma mansoni alpha-1 adrenergic receptor 0.0154 0.0149 0.0146
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0154 0.0149 0.0146
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0007 0.0678
Echinococcus multilocularis neuropeptide Y receptor 0.0154 0.0149 0.0146
Echinococcus granulosus neuropeptide receptor 0.0154 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0045 0.0031 0.0031
Echinococcus granulosus tm gpcr rhodopsin 0.0656 0.0694 0.0691
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0346 0.0358 0.0358
Schistosoma mansoni neuropeptide receptor 0.0154 0.0149 0.0146
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0154 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Trichomonas vaginalis tubulin, putative 0.0066 0.0054 0.1422
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Schistosoma mansoni adenoreceptor 0.0154 0.0149 0.0146
Plasmodium vivax plasmepsin V, putative 0.0082 0.0071 0.1966
Trypanosoma cruzi trypanothione reductase, putative 0.0023 0.0007 0.0712
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0154 0.0149 0.0149
Leishmania major hypothetical protein, conserved 0.0045 0.0031 0.5471
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0128 0.012 0.336
Onchocerca volvulus 0.0154 0.0149 0.3245
Echinococcus granulosus rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Echinococcus multilocularis SWI:SNF matrix associated 0.0128 0.012 0.0117
Loa Loa (eye worm) hypothetical protein 0.0041 0.0026 0.0026
Echinococcus granulosus neuropeptide receptor A26 0.0154 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0154 0.0149 0.0146
Echinococcus granulosus tm gpcr rhodopsin 0.0154 0.0149 0.0146
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0045 0.0031 0.1389
Trichomonas vaginalis tubulin epsilon chain, putative 0.0066 0.0054 0.1422
Plasmodium falciparum plasmepsin V 0.0082 0.0071 0.1966
Echinococcus granulosus neuropeptide Y receptor 0.0154 0.0149 0.0146
Onchocerca volvulus 0.0154 0.0149 0.3245
Brugia malayi hypothetical protein 0.0154 0.0149 0.0149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0149 0.0146
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0154 0.0149 0.0146
Schistosoma mansoni hypothetical protein 0.0154 0.0149 0.0146
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0154 0.0149 0.0149
Echinococcus multilocularis g protein coupled receptor 0.0154 0.0149 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0045 0.0031 0.0031
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0154 0.0149 0.0149
Onchocerca volvulus 0.0045 0.0031 0.0556
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0007 0.0712
Onchocerca volvulus 0.0154 0.0149 0.3245
Onchocerca volvulus 0.0082 0.0071 0.1458
Plasmodium falciparum plasmepsin II 0.0346 0.0358 1
Chlamydia trachomatis guanylate kinase 0.002 0.0003 0.0237
Echinococcus multilocularis lysosome membrane protein 2 0.0041 0.0026 0.0023
Echinococcus multilocularis sex peptide receptor 0.0154 0.0149 0.0146
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0656 0.0694 0.0691
Loa Loa (eye worm) hypothetical protein 0.0024 0.0007 0.0007
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0154 0.0149 0.0146
Echinococcus granulosus 7tm_1 domain containing protein 0.0154 0.0149 0.0146
Schistosoma mansoni tubulin subunit beta 0.0066 0.0054 0.0051
Giardia lamblia NADH oxidase lateral transfer candidate 0.0023 0.0007 0.0719
Trichomonas vaginalis glutathione reductase, putative 0.0023 0.0007 0.0102
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0023 0.0007 0.0539
Loa Loa (eye worm) hypothetical protein 0.9216 1 1
Loa Loa (eye worm) tubulin beta-4 chain 0.0066 0.0054 0.0053
Echinococcus granulosus g protein coupled receptor 0.0154 0.0149 0.0146
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Toxoplasma gondii ran binding protein 0.0045 0.0031 0.0786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0149 0.0146
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Brugia malayi hypothetical protein 0.0154 0.0149 0.0149
Toxoplasma gondii beta-1 tubulin, putative 0.0066 0.0054 0.1422
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Brugia malayi Pepsin A precursor 0.0082 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Loa Loa (eye worm) brahma associated protein 0.0128 0.012 0.012
Onchocerca volvulus Neuropeptide F receptor homolog 0.0154 0.0149 0.3245
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0045 0.0031 0.5471
Plasmodium vivax aspartyl proteinase, putative 0.0346 0.0358 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0023 0.0007 0.0712
Toxoplasma gondii aspartyl protease 0.0082 0.0071 0.1902
Echinococcus granulosus neuropeptides capa receptor 0.0154 0.0149 0.0146
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0007 0.0685
Trypanosoma brucei RNA helicase, putative 0.0205 0.0204 1
Giardia lamblia Beta tubulin 0.0066 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0031 0.0031
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0007 0.9735
Echinococcus multilocularis G protein coupled receptor 139 0.0154 0.0149 0.0146
Trypanosoma brucei hypothetical protein, conserved 0.0045 0.0031 0.1389
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Schistosoma mansoni amine GPCR 0.0154 0.0149 0.0146
Loa Loa (eye worm) melatonin receptor type 1A 0.0154 0.0149 0.0149
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0154 0.0149 0.0146
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0054 0.0051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0149 0.0146
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0007 0.9526
Loa Loa (eye worm) hypothetical protein 0.0041 0.0026 0.0026
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0007 0.0007
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0003
Plasmodium vivax tubulin beta chain, putative 0.0066 0.0054 0.149
Plasmodium vivax hypothetical protein, conserved 0.0128 0.012 0.336
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Echinococcus multilocularis 55 kDa erythrocyte membrane protein 0.0024 0.0007 0.0004
Echinococcus granulosus CD36 class B scavenger receptor 0.0041 0.0026 0.0023
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0154 0.0149 0.0146
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0007 0.0678
Schistosoma mansoni MAGUK homolog 0.0024 0.0007 0.0004
Echinococcus multilocularis MAGUK p55 subfamily 0.0024 0.0007 0.0004
Onchocerca volvulus 0.0024 0.0007 0.0022
Plasmodium falciparum glutathione reductase 0.0023 0.0007 0.0181
Brugia malayi CD36 family protein 0.0041 0.0026 0.0026
Echinococcus granulosus tubulin subunit beta 0.0066 0.0054 0.0051
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0128 0.012 0.3307
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0154 0.0149 0.3245
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.007 0.0058 0.0055
Echinococcus multilocularis thioredoxin glutathione reductase 0.0067 0.0054 0.0051
Plasmodium falciparum tubulin beta chain 0.0066 0.0054 0.149
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0007 0.0181
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0054 0.0051
Echinococcus multilocularis serotonin receptor 0.0154 0.0149 0.0146
Onchocerca volvulus 0.0154 0.0149 0.3245
Brugia malayi follicle stimulating hormone receptor 0.0377 0.0391 0.0391
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0045 0.0031 0.0028
Echinococcus granulosus CD36 class B scavenger receptor 0.0041 0.0026 0.0023
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0045 0.0031 0.0031
Brugia malayi putative neuropeptide receptor NPR1 0.0154 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0346 0.0358 1
Trypanosoma brucei beta tubulin 0.0066 0.0054 0.2511
Echinococcus multilocularis 0.007 0.0058 0.0055
Brugia malayi hypothetical protein 0.0082 0.0071 0.0071
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0023 0.0007 1
Chlamydia trachomatis SWIB complex protein 0.0128 0.012 1
Echinococcus multilocularis somatostatin receptor 0.0154 0.0149 0.0146
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0007 0.0685
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.9216 1 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0066 0.0054 0.0051
Echinococcus multilocularis fmrfamide receptor 0.0154 0.0149 0.0146
Trichomonas vaginalis tubulin epsilon chain, putative 0.0066 0.0054 0.1422
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0045 0.0031 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0154 0.0149 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0712
Echinococcus multilocularis G-protein coupled receptor, putative 0.0154 0.0149 0.0146
Onchocerca volvulus 0.0154 0.0149 0.3245
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0427 0.0446 0.0443
Echinococcus multilocularis g protein coupled receptor 0.0154 0.0149 0.0146
Brugia malayi neuropeptide F receptor 0.0154 0.0149 0.0149
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0154 0.0149 0.0146
Leishmania major trypanothione reductase 0.0067 0.0054 1
Schistosoma mansoni maguk P55 subfamily member 26 0.0024 0.0007 0.0004
Schistosoma mansoni hypothetical protein 0.0128 0.012 0.0117
Trypanosoma cruzi beta tubulin, putative 0.0066 0.0054 0.9893
Echinococcus multilocularis beta tubulin 0.0066 0.0054 0.0051
Echinococcus granulosus beta tubulin 0.0066 0.0054 0.0051
Onchocerca volvulus 0.0045 0.0031 0.0556
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0024 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0045 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0082 0.0071 0.007
Schistosoma mansoni amine GPCR 0.0154 0.0149 0.0146
Schistosoma mansoni histamine h1 receptor 0.0154 0.0149 0.0146
Echinococcus granulosus dro:myosuppressin receptor 0.0154 0.0149 0.0146
Brugia malayi hypothetical protein 0.0154 0.0149 0.0149
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0023 0.0007 0.0712
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0154 0.0149 0.0146
Echinococcus granulosus membrane associated guanylate kinase ww and pdz 0.005 0.0036 0.0033
Mycobacterium ulcerans guanylate kinase 0.002 0.0003 0.4397
Onchocerca volvulus 0.0154 0.0149 0.3245
Onchocerca volvulus 0.0154 0.0149 0.3245
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0154 0.0149 0.0146
Trypanosoma brucei beta tubulin 0.0066 0.0054 0.2511
Echinococcus multilocularis dro:myosuppressin receptor 0.0154 0.0149 0.0146
Onchocerca volvulus 0.0154 0.0149 0.3245
Echinococcus granulosus peptide allatostatin:somatostatin 0.0154 0.0149 0.0146
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0045 0.0031 0.086
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0003
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0154 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0045 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0149 0.0146
Schistosoma mansoni membrane associated guanylate kinase inverted related 0.005 0.0036 0.0033
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0007 0.0685
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Brugia malayi hypothetical protein 0.0154 0.0149 0.0149
Brugia malayi RE15519p 0.0154 0.0149 0.0149
Plasmodium vivax plasmepsin IV, putative 0.0346 0.0358 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Onchocerca volvulus 0.0154 0.0149 0.3245
Plasmodium falciparum thioredoxin reductase 0.0023 0.0007 0.0181
Echinococcus granulosus lysosome membrane protein 2 0.0041 0.0026 0.0023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0007 0.1171
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0007 0.9735
Schistosoma mansoni fusion 0.0045 0.0031 0.0028
Brugia malayi Dopamine receptor protein 1 0.0154 0.0149 0.0149
Brugia malayi Serotonin receptor 0.0154 0.0149 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0007 0.0007
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0346 0.0358 0.0355
Schistosoma mansoni biogenic amine (5HT) receptor 0.0154 0.0149 0.0146
Plasmodium falciparum glutathione reductase 0.0067 0.0054 0.1505
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0023 0.0007 0.0181
Schistosoma mansoni maguk P55 subfamily member 35 0.0024 0.0007 0.0004
Plasmodium falciparum plasmepsin VII 0.0082 0.0071 0.1966
Echinococcus multilocularis g protein coupled receptor 0.0154 0.0149 0.0146
Loa Loa (eye worm) TK/EPH protein kinase 0.0068 0.0055 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Echinococcus granulosus hypothetical protein 0.0154 0.0149 0.0146
Loa Loa (eye worm) aspartyl protease 6 0.0082 0.0071 0.007
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0054 0.0051
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0154 0.0149 0.0146
Schistosoma mansoni hypothetical protein 0.0128 0.012 0.0117
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0067 0.0054 1
Echinococcus granulosus tubulin beta 1 chain 0.0066 0.0054 0.0051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0006
Schistosoma mansoni tubulin subunit beta 0.0066 0.0054 0.0051
Brugia malayi hypothetical protein 0.0041 0.0026 0.0026
Echinococcus multilocularis beta tubulin 0.0066 0.0054 0.0051
Echinococcus granulosus 55 kDa erythrocyte membrane protein 0.0024 0.0007 0.0004
Mycobacterium ulcerans hypothetical protein 0.0023 0.0007 0.9735
Echinococcus granulosus allatostatin A receptor 0.0427 0.0446 0.0443
Toxoplasma gondii thioredoxin reductase 0.0067 0.0054 0.1437
Brugia malayi aspartic protease BmAsp-1, identical 0.0082 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Onchocerca volvulus 0.0053 0.0039 0.0739
Onchocerca volvulus 0.0045 0.0031 0.0556
Onchocerca volvulus 0.0154 0.0149 0.3245
Echinococcus granulosus biogenic amine 5HT receptor 0.0154 0.0149 0.0146
Loa Loa (eye worm) lethal(1)discs large-1 tumor suppressor 0.002 0.0003 0.0003
Treponema pallidum NADH oxidase 0.0023 0.0007 0.5
Trichomonas vaginalis tubulin gamma chain, putative 0.0066 0.0054 0.1422
Brugia malayi Guanylate kinase family protein 0.002 0.0003 0.0003
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0154 0.0149 0.0146
Brugia malayi hypothetical protein 0.002 0.0003 0.0003
Loa Loa (eye worm) BEN-1 protein 0.0066 0.0054 0.0053
Trypanosoma cruzi trypanothione reductase, putative 0.0067 0.0054 1
Brugia malayi ZU5 domain containing protein 0.002 0.0003 0.0003
Onchocerca volvulus 0.0082 0.0071 0.1458
Echinococcus granulosus ephrin type A receptor 4 A 0.0066 0.0053 0.005
Loa Loa (eye worm) tubulin beta chain 0.0066 0.0054 0.0053
Loa Loa (eye worm) guanylate kinase 0.0024 0.0007 0.0007
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0128 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0051 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0007 0.9735
Echinococcus granulosus somatostatin receptor 0.0154 0.0149 0.0146
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0007 1
Plasmodium falciparum plasmepsin I 0.0346 0.0358 1
Brugia malayi hypothetical protein 0.0154 0.0149 0.0149
Echinococcus multilocularis fmrfamide receptor 0.0154 0.0149 0.0146
Brugia malayi hypothetical protein 0.0082 0.0071 0.0071
Echinococcus multilocularis ephrin type A receptor 4 A 0.0066 0.0053 0.005
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Brugia malayi Dopamine receptor protein 2 0.0154 0.0149 0.0149
Loa Loa (eye worm) TYRA-2 protein 0.0154 0.0149 0.0149
Brugia malayi G protein-coupled receptor 0.0154 0.0149 0.0149
Loa Loa (eye worm) tubulin beta-1 chain 0.0066 0.0054 0.0053
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0023 0.0007 0.0004
Brugia malayi Eukaryotic aspartyl protease family protein 0.0082 0.0071 0.0071
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0007 0.0678
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0082 0.0071 0.0068
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0023 0.0007 0.0181
Schistosoma mansoni hypothetical protein 0.0205 0.0204 0.0201
Trichomonas vaginalis tubulin beta chain, putative 0.0066 0.0054 0.1422
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0154 0.0149 0.0146
Loa Loa (eye worm) neuropeptide F receptor 0.0154 0.0149 0.0149
Brugia malayi YY1-associated factor 2 0.0045 0.0031 0.0031
Brugia malayi aspartic protease BmAsp-2, identical 0.0082 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0006
Brugia malayi Dopamine receptor 0.0154 0.0149 0.0149
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0082 0.0071 0.0068
Brugia malayi G protein-coupled receptor F59B2.13 0.0154 0.0149 0.0149
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0023 0.0007 0.0181
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Schistosoma mansoni hypothetical protein 0.0128 0.012 0.0117
Schistosoma mansoni CD36-like class B scavenger receptor 0.0041 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0045 0.0031 0.0031
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0082 0.0071 0.1902
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0054 0.0051
Brugia malayi hypothetical protein 0.0154 0.0149 0.0149
Echinococcus granulosus fmrfamide receptor 0.0154 0.0149 0.0146
Loa Loa (eye worm) BEN-1 protein 0.0066 0.0054 0.0053
Schistosoma mansoni RNA binding protein 0.0045 0.0031 0.0028
Brugia malayi Thioredoxin reductase 0.0067 0.0054 0.0054
Echinococcus granulosus 3'partial|membrane associated guanylate kinase ww and pdz 0.005 0.0036 0.0033
Brugia malayi G-protein coupled receptor 0.0154 0.0149 0.0149
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0712
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0054 0.0051
Echinococcus multilocularis neuropeptide receptor 0.0154 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Brugia malayi hypothetical protein 0.0154 0.0149 0.0149
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0023 0.0007 0.1203
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0154 0.0149 0.0146
Schistosoma mansoni biogenic amine receptor 0.0154 0.0149 0.0146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0149 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Echinococcus granulosus neuropeptide s receptor 0.0154 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Toxoplasma gondii beta-tubulin, putative 0.0066 0.0054 0.1422
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Schistosoma mansoni TRABID protein (C64 family) 0.0045 0.0031 0.0028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0712
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0154 0.0149 0.0146
Schistosoma mansoni hypothetical protein 0.0154 0.0149 0.0146
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0045 0.0031 0.0031
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0082 0.0071 0.0068
Brugia malayi beta-tubulin, identical 0.0066 0.0054 0.0054
Echinococcus granulosus tubulin beta 4A class IVa 0.0066 0.0054 0.0051
Echinococcus multilocularis neuropeptide s receptor 0.0154 0.0149 0.0146
Chlamydia trachomatis DNA topoisomerase I 0.0128 0.012 1
Brugia malayi brahma associated protein 60 kDa 0.0128 0.012 0.012
Echinococcus multilocularis SWI:SNF matrix associated 0.0128 0.012 0.0117
Schistosoma mansoni neuropeptide f receptor 76f 0.0154 0.0149 0.0146
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0045 0.0031 0.0028
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0054 0.0051
Echinococcus granulosus beta tubulin 0.0066 0.0054 0.0051
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0024 0.0007 0.0004
Loa Loa (eye worm) hypothetical protein 0.0041 0.0026 0.0026
Echinococcus multilocularis membrane associated guanylate kinase, WW and PDZ 0.005 0.0036 0.0033
Echinococcus multilocularis neuropeptide Y receptor 0.0154 0.0149 0.0146
Loa Loa (eye worm) G-protein coupled receptor 0.0154 0.0149 0.0149
Schistosoma mansoni biogenic amine receptor 0.0154 0.0149 0.0146
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0054 0.0051
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Loa Loa (eye worm) hypothetical protein 0.0346 0.0358 0.0358
Echinococcus granulosus CD36 class B scavenger receptor 0.0041 0.0026 0.0023
Echinococcus multilocularis ring and YY1 binding protein 0.0045 0.0031 0.0028
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Echinococcus granulosus rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Echinococcus granulosus neuropeptides capa receptor 0.0154 0.0149 0.0146
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0082 0.0071 0.0068
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0023 0.0007 0.0004
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0045 0.0031 0.5471
Schistosoma mansoni zinc finger protein 0.0045 0.0031 0.0028
Brugia malayi putative neuropeptide receptor 0.0154 0.0149 0.0149
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0045 0.0031 0.5471
Loa Loa (eye worm) beta-tubulin 0.0066 0.0054 0.0053
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0023 0.0007 0.0181
Echinococcus granulosus CD36 class B scavenger receptor 0.0041 0.0026 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Echinococcus granulosus disks large 3 0.0024 0.0007 0.0004
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0154 0.0149 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0154 0.0149 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Plasmodium vivax aspartyl protease, putative 0.0082 0.0071 0.1966
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0007 0.9735
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Schistosoma mansoni ephrin receptor 0.0053 0.004 0.0037
Trypanosoma brucei beta tubulin 0.0066 0.0054 0.2511
Echinococcus granulosus zinc finger protein Ran binding 0.0045 0.0031 0.0028
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0346 0.0358 0.0355
Echinococcus granulosus rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Trypanosoma cruzi WLM domain containing protein, putative 0.0045 0.0031 0.5471
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0154 0.0149 0.0146
Echinococcus multilocularis g-protein coupled receptor 0.0154 0.0149 0.0146
Brugia malayi neuropeptide F receptor 0.0154 0.0149 0.0149
Plasmodium falciparum plasmepsin IX 0.0082 0.0071 0.1966
Loa Loa (eye worm) voltage-dependent calcium channel beta 2a subunit 0.002 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0003
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0128 0.012 0.336
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Echinococcus multilocularis CD36 class B scavenger receptor 0.0041 0.0026 0.0023
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0023 0.0007 0.0102
Onchocerca volvulus 0.0045 0.0031 0.0556
Loa Loa (eye worm) glutathione reductase 0.0067 0.0054 0.0054
Onchocerca volvulus 0.0128 0.012 0.2593
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Schistosoma mansoni cd36 antigen 0.0041 0.0026 0.0023
Plasmodium vivax aspartyl protease, putative 0.0082 0.0071 0.1966
Schistosoma mansoni biogenic amine receptor 0.0154 0.0149 0.0146
Echinococcus granulosus MAGUK p55 subfamily 0.0024 0.0007 0.0004
Echinococcus granulosus neuropeptide receptor 0.0154 0.0149 0.0146
Brugia malayi Melatonin receptor type 1A 0.0154 0.0149 0.0149
Echinococcus granulosus membrane associated guanylate kinase, WW and PDZ 0.005 0.0036 0.0033
Entamoeba histolytica tubulin family protein 0.0066 0.0054 1
Brugia malayi abnormal cell lineage protein 2 0.002 0.0003 0.0003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0023 0.0007 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0023 0.0007 1
Onchocerca volvulus 0.0154 0.0149 0.3245
Echinococcus granulosus rhodopsin orphan GPCR 0.0154 0.0149 0.0146
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0154 0.0149 0.0149
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0007 0.1171
Echinococcus granulosus g-protein coupled receptor 0.0154 0.0149 0.0146
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0154 0.0149 0.0149
Echinococcus multilocularis neuropeptide FF receptor 2 0.0154 0.0149 0.0146
Loa Loa (eye worm) tubulin beta-2A chain 0.0066 0.0054 0.0053
Schistosoma mansoni MAGUK homolog 0.0024 0.0007 0.0004
Loa Loa (eye worm) G-protein coupled receptor 0.0154 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0045 0.0031 0.1389
Echinococcus multilocularis neuropeptide receptor 0.0154 0.0149 0.0146
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0154 0.0149 0.0149
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0154 0.0149 0.0146
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0007 0.9526
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.0041 0.0026 0.0449
Onchocerca volvulus 0.0154 0.0149 0.3245
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0082 0.0071 0.0068
Schistosoma mansoni tubulin subunit beta 0.0066 0.0054 0.0051
Loa Loa (eye worm) hypothetical protein 0.0427 0.0446 0.0446
Schistosoma mansoni neuropeptide receptor 0.0154 0.0149 0.0146
Toxoplasma gondii NADPH-glutathione reductase 0.0023 0.0007 0.0102
Schistosoma mansoni CD36-like class B scavenger receptor 0.0041 0.0026 0.0023
Leishmania major hypothetical protein, conserved 0.0045 0.0031 0.5471
Echinococcus granulosus orexin receptor type 2 0.0154 0.0149 0.0146
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0082 0.0071 0.0068
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Echinococcus granulosus ring and YY1 binding protein 0.0045 0.0031 0.0028
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0045 0.0031 0.0556
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0031 0.5471
Echinococcus multilocularis neuropeptide receptor A26 0.0154 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0054 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0031 0.5471
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0149 0.0146
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0023 0.0007 0.0004
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0082 0.0071 0.0068
Plasmodium falciparum thioredoxin reductase 0.0067 0.0054 0.1505
Brugia malayi sulfakinin receptor protein 0.0154 0.0149 0.0149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0712
Schistosoma mansoni ATP-dependent RNA Helicase 0.0024 0.0007 0.0004
Echinococcus multilocularis CD36 class B scavenger receptor 0.0041 0.0026 0.0023
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0045 0.0031 0.5471
Schistosoma mansoni hypothetical protein 0.0045 0.0031 0.0028
Echinococcus multilocularis disks large 3 0.0024 0.0007 0.0004
Schistosoma mansoni myosin xvIII 0.0154 0.0149 0.0146
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Echinococcus granulosus 7TM GPCR rhodopsin 0.0154 0.0149 0.0146
Schistosoma mansoni hypothetical protein 0.0154 0.0149 0.0146
Brugia malayi hypothetical protein 0.0154 0.0149 0.0149
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.9216 1 1
Onchocerca volvulus 0.0154 0.0149 0.3245
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0023 0.0007 0.0712
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0082 0.0071 0.007
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0154 0.0149 0.0149
Echinococcus granulosus g protein coupled receptor 0.0154 0.0149 0.0146
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0128 0.012 0.336
Schistosoma mansoni opsin-like receptor 0.0154 0.0149 0.0146
Brugia malayi AKH receptor 0.0154 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0154 0.0149 0.0146
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0007 0.9735
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Leishmania major hypothetical protein, conserved 0.0045 0.0031 0.5471
Plasmodium falciparum plasmepsin III 0.0082 0.0071 0.1966
Onchocerca volvulus 0.0154 0.0149 0.3245
Schistosoma mansoni amine GPCR 0.0154 0.0149 0.0146
Echinococcus granulosus sex peptide receptor 0.0154 0.0149 0.0146
Leishmania major beta tubulin 0.0066 0.0054 0.9893
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0023 0.0007 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Leishmania major hypothetical protein, conserved 0.0045 0.0031 0.5471
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0023 0.0007 0.0181
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0154 0.0149 0.0146
Echinococcus granulosus tachykinin peptides receptor 99D 0.0154 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0011
Giardia lamblia Beta tubulin 0.0066 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0023 0.0007 0.0007
Echinococcus multilocularis orexin receptor type 2 0.0154 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0154 0.0149 0.0149
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0154 0.0149 0.0146
Brugia malayi SWIB/MDM2 domain containing protein 0.0128 0.012 0.012
Echinococcus multilocularis CD36 class B scavenger receptor 0.0041 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.0023 0.0007 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0007 0.0007
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0128 0.012 0.3307
Echinococcus granulosus alpha 1A adrenergic receptor 0.0154 0.0149 0.0146
Brugia malayi Guanylate kinase family protein 0.0024 0.0007 0.0007
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0054 0.0051
Echinococcus granulosus MAGUK p55 subfamily 0.0024 0.0007 0.0004
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0154 0.0149 0.0149
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0154 0.0149 0.0146
Loa Loa (eye worm) peripheral plasma membrane protein CASK 0.0024 0.0007 0.0007
Schistosoma mansoni memapsin-2 (A01 family) 0.0082 0.0071 0.0068
Schistosoma mansoni cell polarity protein 0.0024 0.0007 0.0004
Plasmodium vivax glutathione reductase, putative 0.0067 0.0054 0.1505
Schistosoma mansoni cathepsin D (A01 family) 0.1022 0.1092 0.1089

Activities

Activity type Activity value Assay description Source Reference
Increase (functional) % In vitro agonist activity at P2Y1 receptor in turkey erythrocyte membranes; No effect at 100 uM. ChEMBL. 10229631
Inhibition (functional) % Antagonist activity for inhibition of PLC elicited by 10 nM 2-MeSADP at P2Y purinoceptor 1 in the turkey erythrocyte membranes; No effect, low potency ChEMBL. 10229631

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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