TDR Targets

Basic information

Technical information

TDR Targets ID: 1851669
Name: 4-hydroxy-1,3-dihydrobenzimidazol-2-one
MW: 150.135 | Formula: C7H6N2O2
H donors: 3 H acceptors: 2 LogP: 0.21 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: O=c1[nH]c2c([nH]1)cccc2O
InChi: 1S/C7H6N2O2/c10-5-3-1-2-4-6(5)9-7(11)8-4/h1-3,10H,(H2,8,9,11)
InChiKey: CPBGGIHYAYWNDD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0078	0.0573	0.2191
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0573	0.2191
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.2614	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.017	0.2614	1
Brugia malayi	myotactin form A	0.017	0.2614	1
Onchocerca volvulus		0.017	0.2614	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.2614	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.2614	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0134	0.1807	0.1807
Brugia malayi	beta-lactamase	0.0078	0.0573	0.2191
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0573	0.2191
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.017	0.2614	0.7011
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.017	0.2614	1
Loa Loa (eye worm)	CAMK protein kinase	0.017	0.2614	1
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.017	0.2614	0.7011
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0078	0.0573	0.052
Brugia malayi	Fibronectin type III domain containing protein	0.017	0.2614	1
Echinococcus granulosus	contactin	0.017	0.2614	0.7011
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.017	0.2614	1
Echinococcus multilocularis	Netrin receptor DCC	0.017	0.2614	0.7011
Mycobacterium ulcerans	beta-lactamase	0.0078	0.0573	0.5
Mycobacterium tuberculosis	Probable dehydrogenase	0.012	0.1507	0.1507
Loa Loa (eye worm)	lethal protein 805	0.017	0.2614	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.017	0.2614	0.7011
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.017	0.2614	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0078	0.0573	0.2191
Echinococcus granulosus	nephrin	0.017	0.2614	0.7011
Trichomonas vaginalis	penicillin-binding protein, putative	0.0078	0.0573	0.5
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0078	0.0573	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.022	0.3728	1
Mycobacterium ulcerans	hypothetical protein	0.0078	0.0573	0.5
Schistosoma mansoni	titin	0.017	0.2614	0.6652
Echinococcus granulosus	G1Y162 protein	0.017	0.2614	0.7011
Brugia malayi	Lethal protein 805	0.017	0.2614	1
Brugia malayi	hypothetical protein	0.017	0.2614	1
Leishmania major	hypothetical protein, conserved	0.0078	0.0573	0.2191
Echinococcus granulosus	roundabout 2	0.017	0.2614	0.7011
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0078	0.0573	0.0573
Brugia malayi	myotactin form B	0.017	0.2614	1
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.017	0.2614	0.7011
Leishmania major	hypothetical protein, conserved	0.017	0.2614	1
Echinococcus granulosus	tar DNA binding protein	0.0071	0.04	0.1072
Brugia malayi	hypothetical protein	0.017	0.2614	1
Brugia malayi	protein unc-22	0.017	0.2614	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.017	0.2614	0.7011
Echinococcus multilocularis	anosmin 1	0.017	0.2614	0.7011
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0573	0.2191
Schistosoma mansoni	factor for adipocyte differentiation	0.017	0.2614	0.6652
Schistosoma mansoni	cell adhesion molecule	0.017	0.2614	0.6652
Echinococcus granulosus	titin	0.017	0.2614	0.7011
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.017	0.2614	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.2614	1
Brugia malayi	Protein-tyrosine phosphatase	0.017	0.2614	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Schistosoma mansoni	hypothetical protein	0.017	0.2614	0.6652
Echinococcus granulosus	anosmin 1	0.017	0.2614	0.7011
Schistosoma mansoni	titin	0.017	0.2614	0.6652
Echinococcus multilocularis	anosmin 1	0.017	0.2614	0.7011
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.012	0.1507	0.7573
Trichomonas vaginalis	D-aminoacylase, putative	0.0078	0.0573	0.5
Echinococcus granulosus	roundabout 2	0.017	0.2614	0.7011
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Echinococcus multilocularis	roundabout 2	0.017	0.2614	0.7011
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.017	0.2614	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.017	0.2614	1
Onchocerca volvulus		0.017	0.2614	1
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.017	0.2614	0.7011
Schistosoma mansoni	cell adhesion molecule	0.017	0.2614	0.6652
Echinococcus multilocularis	titin	0.017	0.2614	0.7011
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.017	0.2614	1
Echinococcus granulosus	anosmin 1	0.017	0.2614	0.7011
Brugia malayi	SPRY domain containing protein	0.017	0.2614	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Echinococcus granulosus	fibronectin type III domain-containing protein	0.017	0.2614	0.7011
Schistosoma mansoni	factor for adipocyte differentiation	0.017	0.2614	0.6652
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0573	0.2191
Mycobacterium tuberculosis	Conserved protein	0.0078	0.0573	0.0573
Onchocerca volvulus		0.017	0.2614	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.017	0.2614	1
Brugia malayi	beta-lactamase family protein	0.0078	0.0573	0.2191
Mycobacterium tuberculosis	Probable esterase LipL	0.0078	0.0573	0.0573
Brugia malayi	beta-lactamase family protein	0.0078	0.0573	0.2191
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0078	0.0573	0.0573
Brugia malayi	RNA binding protein	0.0071	0.04	0.1529
Schistosoma mansoni	hypothetical protein	0.017	0.2614	0.6652
Echinococcus granulosus	Netrin receptor DCC	0.017	0.2614	0.7011
Trichomonas vaginalis	D-aminoacylase, putative	0.0078	0.0573	0.5
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.012	0.1507	0.1507
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.017	0.2614	0.6652
Plasmodium vivax	hypothetical protein, conserved	0.0078	0.0573	1
Plasmodium falciparum	glutathione reductase	0.0053	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Schistosoma mansoni	cell adhesion molecule	0.017	0.2614	0.6652
Schistosoma mansoni	nephrin	0.017	0.2614	0.6652
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.012	0.1507	0.1507
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Schistosoma mansoni	titin	0.017	0.2614	0.6652
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.017	0.2614	0.7011
Onchocerca volvulus		0.017	0.2614	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0078	0.0573	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0573	0.2191
Mycobacterium tuberculosis	Probable lipase LipD	0.0078	0.0573	0.0573
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.017	0.2614	0.7011
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0134	0.1807	0.1807
Schistosoma mansoni	tripartite motif protein trim9	0.017	0.2614	0.6652
Onchocerca volvulus		0.017	0.2614	1
Onchocerca volvulus		0.017	0.2614	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.017	0.2614	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Schistosoma mansoni	myosin-binding protein-related	0.017	0.2614	0.6652
Onchocerca volvulus		0.017	0.2614	1
Onchocerca volvulus		0.017	0.2614	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.017	0.2614	0.7011
Brugia malayi	Fibronectin type III domain containing protein	0.017	0.2614	1
Loa Loa (eye worm)	RNA binding protein	0.0071	0.04	0.1529
Plasmodium falciparum	thioredoxin reductase	0.0053	0	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.2614	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.017	0.2614	0.7011
Echinococcus multilocularis	Netrin receptor DCC	0.017	0.2614	0.7011
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0078	0.0573	0.1536
Mycobacterium tuberculosis	Probable lipase LipE	0.0078	0.0573	0.0573
Loa Loa (eye worm)	myotactin form A	0.017	0.2614	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.2614	1
Schistosoma mansoni	factor for adipocyte differentiation	0.017	0.2614	0.6652
Schistosoma mansoni	protein tyrosine phosphatase	0.017	0.2614	0.6652
Trypanosoma brucei	hypothetical protein, conserved	0.0078	0.0573	0.2191
Mycobacterium tuberculosis	Probable hydrolase	0.0078	0.0573	0.0573
Trichomonas vaginalis	penicillin-binding protein, putative	0.0078	0.0573	0.5
Schistosoma mansoni	neuroglian	0.017	0.2614	0.6652
Brugia malayi	Lethal protein 805	0.017	0.2614	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.017	0.2614	0.7011
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0134	0.1807	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.017	0.2614	0.6652
Brugia malayi	Fibronectin type III domain containing protein	0.017	0.2614	1
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.017	0.2614	1
Schistosoma mansoni	hemicentin	0.017	0.2614	0.6652
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.2614	1
Brugia malayi	Fibronectin type III domain containing protein	0.017	0.2614	1
Trypanosoma cruzi	hypothetical protein, conserved	0.017	0.2614	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.017	0.2614	1
Schistosoma mansoni	ephrin receptor	0.022	0.3728	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.017	0.2614	1
Echinococcus granulosus	titin	0.017	0.2614	0.7011
Mycobacterium tuberculosis	Conserved protein	0.0078	0.0573	0.0573
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0071	0.04	0.1529
Brugia malayi	Fibronectin type III domain containing protein	0.017	0.2614	1
Trichomonas vaginalis	esterase, putative	0.0078	0.0573	0.5
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.017	0.2614	0.7011
Schistosoma mansoni	nephrin	0.017	0.2614	0.6652
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.017	0.2614	0.7011
Onchocerca volvulus		0.017	0.2614	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.017	0.2614	0.7011
Echinococcus multilocularis	roundabout 2	0.017	0.2614	0.7011
Onchocerca volvulus		0.017	0.2614	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.017	0.2614	1
Echinococcus multilocularis	anosmin 1	0.017	0.2614	0.7011
Loa Loa (eye worm)	UNCoordinated family member	0.017	0.2614	1
Echinococcus granulosus	anosmin 1	0.017	0.2614	0.7011
Echinococcus multilocularis	tar DNA binding protein	0.0071	0.04	0.1072
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.012	0.1507	0.1507
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0078	0.0573	0.5
Mycobacterium tuberculosis	Probable reductase	0.012	0.1507	0.1507
Echinococcus granulosus	usherin	0.017	0.2614	0.7011
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0134	0.1807	0.1807
Onchocerca volvulus		0.017	0.2614	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.2614	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0573	0.2191
Loa Loa (eye worm)	TAR-binding protein	0.0071	0.04	0.1529
Echinococcus multilocularis	cell adhesion molecule	0.017	0.2614	0.7011
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.2614	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.017	0.2614	1
Echinococcus granulosus	neuroglian	0.017	0.2614	0.7011
Echinococcus multilocularis	roundabout 2	0.017	0.2614	0.7011
Schistosoma mansoni	cell adhesion molecule	0.017	0.2614	0.6652
Loa Loa (eye worm)	projectin	0.017	0.2614	1
Echinococcus granulosus	Fibronectin type III	0.017	0.2614	0.7011
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Onchocerca volvulus		0.017	0.2614	1
Onchocerca volvulus		0.017	0.2614	1
Toxoplasma gondii	ABC1 family protein	0.0078	0.0573	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.2614	1
Schistosoma mansoni	hypothetical protein	0.017	0.2614	0.6652
Echinococcus multilocularis	neuroglian	0.017	0.2614	0.7011
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.2614	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.017	0.2614	0.6652
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.017	0.2614	0.7011
Schistosoma mansoni	cell adhesion molecule	0.017	0.2614	0.6652
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.017	0.2614	0.6652
Schistosoma mansoni	serine/threonine protein kinase	0.017	0.2614	0.6652
Onchocerca volvulus		0.017	0.2614	1
Echinococcus granulosus	roundabout 2	0.017	0.2614	0.7011
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0078	0.0573	0.0573
Echinococcus multilocularis	transfer RNA-Phe	0.017	0.2614	0.7011
Echinococcus multilocularis	titin	0.017	0.2614	0.7011
Echinococcus granulosus	beta LACTamase domain containing family member	0.0078	0.0573	0.1536
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.017	0.2614	0.7011
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.017	0.2614	1
Echinococcus multilocularis	usherin	0.017	0.2614	0.7011
Mycobacterium ulcerans	lipase LipD	0.0078	0.0573	0.5
Mycobacterium tuberculosis	Conserved protein	0.0078	0.0573	0.0573
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.012	0.1507	0.1507
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0573	0.2191
Brugia malayi	Fibronectin type III domain containing protein	0.017	0.2614	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0573	0.2191
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.017	0.2614	1
Echinococcus granulosus	cell adhesion molecule	0.017	0.2614	0.7011
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.017	0.2614	0.6652
Echinococcus granulosus	Netrin receptor DCC	0.017	0.2614	0.7011
Echinococcus multilocularis	Fibronectin, type III	0.017	0.2614	0.7011
Brugia malayi	TAR-binding protein	0.0071	0.04	0.1529
Loa Loa (eye worm)	hypothetical protein	0.017	0.2614	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.2614	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.017	0.2614	0.7011
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.022	0.3728	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0078	0.0573	0.052
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.017	0.2614	0.7011
Loa Loa (eye worm)	beta-lactamase	0.0078	0.0573	0.2191
Brugia malayi	RNA recognition motif domain containing protein	0.0071	0.04	0.1529
Echinococcus granulosus	Fibronectin type III domain containing protein	0.017	0.2614	0.7011
Echinococcus granulosus	EG95	0.017	0.2614	0.7011

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3218379

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1851669