Detailed information for compound 1852238

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 570.642 | Formula: C30H34N8O4
  • H donors: 2 H acceptors: 5 LogP: 2.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=CC(=O)Nc1cccc(c1)N1C(=O)C(C)N(C(=O)c2c1nc(nc2)Nc1ccc(cc1OC)N1CCN(CC1)C)C
  • InChi: 1S/C30H34N8O4/c1-6-26(39)32-20-8-7-9-22(16-20)38-27-23(29(41)36(4)19(2)28(38)40)18-31-30(34-27)33-24-11-10-21(17-25(24)42-5)37-14-12-35(3)13-15-37/h6-11,16-19H,1,12-15H2,2-5H3,(H,32,39)(H,31,33,34)
  • InChiKey: KWCSAJCODOPDPD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens erb-b2 receptor tyrosine kinase 4 No references
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL No references
Homo sapiens erb-b2 receptor tyrosine kinase 3 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0008 0.0012 0.0012
Schistosoma mansoni alpha glucosidase 0.0013 0.0128 0.0128
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0014 0.0134 0.0506
Loa Loa (eye worm) hypothetical protein 0.0024 0.0341 0.0341
Loa Loa (eye worm) TK/INSR protein kinase 0.0156 0.3034 0.3034
Mycobacterium tuberculosis Probable dehydrogenase 0.0032 0.0502 0.1158
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0013 0.0126 0.0126
Schistosoma mansoni tyrosine kinase 0.0156 0.3034 0.3034
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0278 0.4089
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0091 0.0281
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0128 0.0258
Loa Loa (eye worm) hypothetical protein 0.0011 0.0086 0.0086
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0165 0.0448
Schistosoma mansoni nuclear receptor 0.0011 0.0086 0.0086
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0022 0.0297 0.0297
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0024 0.0351 0.153
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0037 0.0073
Echinococcus granulosus L aminoadipate semialdehyde 0.0031 0.0478 0.0478
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0341 0.0341
Entamoeba histolytica phosphofructokinase, putative 0.004 0.0669 0.3173
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0128 0.0182
Loa Loa (eye worm) hypothetical protein 0.0011 0.0086 0.0086
Echinococcus multilocularis zinc finger protein 0.0007 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0086 0.0086
Leishmania major trypanothione reductase 0.0014 0.014 0.0518
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0086 0.0086
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0128 0.0475
Loa Loa (eye worm) hypothetical protein 0.0024 0.0341 0.0341
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0032 0.0502 0.1158
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0014 0.0134 0.0134
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0208 0.4087 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0341 0.0341
Echinococcus multilocularis lysosomal alpha glucosidase 0.006 0.1074 0.1074
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0278 0.0926
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0128 0.0258
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0086 0.0086
Schistosoma mansoni coup transcription factor 0.0024 0.0341 0.0341
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0113 0.0113
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0341 0.0829
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0341 0.0341
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0008 0.0026 0.0026
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0014 0.0146 0.4612
Trypanosoma brucei protein kinase, putative 0.0019 0.0242 0.1009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0086 0.0086
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.004 0.0669 0.3062
Schistosoma mansoni zinc finger protein 0.0007 0.0004 0.0004
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0156 0.3034 0.3034
Loa Loa (eye worm) hypothetical protein 0.0055 0.0973 0.0973
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0014 0.0134 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0341 0.0341
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0022 0.0303 0.0303
Echinococcus granulosus lysosomal alpha glucosidase 0.006 0.1074 0.1074
Loa Loa (eye worm) hypothetical protein 0.001 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0086 0.0086
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0128 0.0258
Echinococcus multilocularis microtubule associated protein 2 0.0254 0.5009 0.5009
Trichomonas vaginalis sucrase-isomaltase, putative 0.0013 0.0128 0.0258
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0024 0.0351 0.0351
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0032 0.0502 0.1158
Loa Loa (eye worm) hypothetical protein 0.0011 0.0072 0.0072
Schistosoma mansoni bromodomain containing protein 0.0023 0.033 0.033
Onchocerca volvulus 0.0024 0.0341 0.0829
Schistosoma mansoni apoptosis regulator bax 0.003 0.0476 0.0476
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0016 0.0175 0.0415
Onchocerca volvulus 0.0163 0.3164 1
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0341 0.0341
Toxoplasma gondii phosphofructokinase PFKII 0.0011 0.0077 0.0743
Loa Loa (eye worm) hypothetical protein 0.0011 0.0086 0.0086
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.003 0.0476 0.0476
Trichomonas vaginalis CMGC family protein kinase 0.0019 0.0242 0.0842
Schistosoma mansoni tyrosine kinase 0.05 1 1
Echinococcus granulosus transcription factor Dp 1 0.0014 0.0143 0.0143
Schistosoma mansoni DNA helicase recq5 0.0011 0.0072 0.0072
Schistosoma mansoni tyrosine kinase 0.0333 0.6616 0.6616
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0107 0.2039 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0107 0.2039 1
Trichomonas vaginalis phosphofructokinase, putative 0.004 0.0669 0.3017
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0019 0.0242 0.1009
Echinococcus multilocularis insulin receptor 0.0156 0.3034 0.3034
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0014 0.0134 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0341 0.0341
Mycobacterium tuberculosis Probable oxidoreductase 0.0035 0.0574 0.1335
Brugia malayi nuclear receptor NHR-88 0.0011 0.0086 0.0086
Loa Loa (eye worm) phosphofructokinase 0.004 0.0669 0.0669
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.0208 0.4087 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0011 0.0077 0.0743
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0144
Brugia malayi 6-phosphofructokinase 0.004 0.0669 0.0669
Brugia malayi MAP kinase sur-1 0.0019 0.0242 0.0242
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0014 0.0134 0.0488
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0107 0.2039 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0341 0.0341
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0009 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.006 0.1077 0.1077
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0341 0.0341
Loa Loa (eye worm) 6-phosphofructokinase 0.004 0.0669 0.0669
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0341 0.0341
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0014 0.0134 0.0488
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0032 0.0502 0.1158
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0014 0.014 0.0266
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0038 0.0633 0.1482
Echinococcus multilocularis transcription factor Dp 1 0.0014 0.0143 0.0143
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0011 0.0077 0.0222
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0072 0.0651
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.004 0.0669 0.3173
Trichomonas vaginalis CMGC family protein kinase 0.0019 0.0242 0.0842
Loa Loa (eye worm) hypothetical protein 0.0011 0.0086 0.0086
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0341 0.0341
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0024 0.0351 0.1585
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0019 0.0242 0.0749
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0111 0.2112 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0128 0.0258
Brugia malayi Thioredoxin reductase 0.0014 0.014 0.014
Echinococcus granulosus fetal alzheimer antigen falz 0.0008 0.0026 0.0026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0341 0.0341
Trichomonas vaginalis DNA helicase recq1, putative 0.0015 0.0165 0.0448
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0341 0.0341
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0341 0.0341
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0014 0.0134 0.0134
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0341 0.0341
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0035 0.0574 0.1335
Plasmodium vivax 6-phosphofructokinase, putative 0.0011 0.0077 0.1817
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0091 0.0281
Brugia malayi nuclear receptor NHR-88 0.0024 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0011 0.0086 0.0086
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0341 0.0341
Brugia malayi ecdysteroid receptor 0.0024 0.0341 0.0341
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0019 0.0242 0.3493
Schistosoma mansoni zinc finger protein 0.0011 0.0086 0.0086
Brugia malayi hypothetical protein 0.0011 0.0086 0.0086
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0072 0.0072
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0009 0.0046 0.0046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0341 0.0341
Echinococcus multilocularis myotubularin protein 13 0.0008 0.0029 0.0029
Trypanosoma brucei trypanothione reductase 0.0014 0.014 0.0518
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.003 0.0476 0.0476
Echinococcus granulosus microtubule associated protein 2 0.0254 0.5009 0.5009
Leishmania major alpha glucosidase II subunit, putative 0.0013 0.0128 0.0458
Onchocerca volvulus 0.0035 0.0561 0.1545
Schistosoma mansoni alpha-glucosidase 0.0052 0.0905 0.0905
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0031 0.0478 0.0478
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0341 0.0341
Brugia malayi PHD-finger family protein 0.0009 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0086 0.0086
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0072 0.0072
Loa Loa (eye worm) 6-phosphofructokinase 0.004 0.0669 0.0669
Schistosoma mansoni tyrosine kinase 0.0331 0.6575 0.6575
Loa Loa (eye worm) DR-78 0.0011 0.0086 0.0086
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0278 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0156 0.3034 0.3034
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0019 0.0242 0.1009
Onchocerca volvulus 0.0031 0.0478 0.1276
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0107 0.2039 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0633 0.1482
Loa Loa (eye worm) hypothetical protein 0.0062 0.1114 0.1114
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0113 0.0113
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0128 0.0258
Echinococcus granulosus thioredoxin glutathione reductase 0.0014 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0163 0.3164 0.3164
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0086 0.0086
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0014 0.0134 0.0134
Brugia malayi nuclear receptor NHR-67 0.0011 0.0086 0.0086
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0341 0.0341
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0113 0.0113
Trichomonas vaginalis CMGC family protein kinase 0.0019 0.0242 0.0842
Loa Loa (eye worm) hypothetical protein 0.0024 0.0341 0.0341
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0011 0.0077 0.1817
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0086 0.0086
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0086 0.0086
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.003 0.0476 0.0476
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0024 0.0351 0.0351
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0072 0.1593
Leishmania major ATP-dependent phosphofructokinase 0.004 0.0669 0.3062
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0013 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0013 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0013 0.0113 0.0113
Schistosoma mansoni nuclear receptor 0.0011 0.0086 0.0086
Echinococcus multilocularis muscleblind protein 1 0.0055 0.0973 0.0973
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0341 0.0341
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.014 0.0244
Loa Loa (eye worm) runx1 0.002 0.0273 0.0273
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0111 0.2112 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0072 0.0072
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0072 0.0072
Loa Loa (eye worm) TK/EGFR protein kinase 0.05 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0128 0.0128
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0086 0.0086
Echinococcus granulosus neutral alpha glucosidase AB 0.0013 0.0128 0.0128
Brugia malayi hypothetical protein 0.0013 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0011 0.0086 0.0086
Toxoplasma gondii 6-phosphofructokinase 0.0011 0.0077 0.0743
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0341 0.0341
Brugia malayi nuclear receptor RXR 0.0013 0.0113 0.0113
Brugia malayi hypothetical protein 0.0013 0.0113 0.0113
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.004 0.0669 0.157
Treponema pallidum licC protein (licC) 0.0038 0.0633 0.2994
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0091 0.0291
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0072 0.0072
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0054 0.095 0.095
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0024 0.0351 0.1285
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0014 0.0134 0.029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0086 0.0086
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0038 0.0633 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0014 0.0134 0.029
Schistosoma mansoni hypothetical protein 0.003 0.0476 0.0476
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0107 0.2039 1
Schistosoma mansoni lozenge 0.002 0.0273 0.0273
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0107 0.2039 1
Toxoplasma gondii hypothetical protein 0.0018 0.0221 0.3146
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0014 0.0134 0.0134
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0014 0.0134 0.0134
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0086 0.0086
Echinococcus granulosus zinc finger protein 0.0007 0.0004 0.0004
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0016 0.0175 0.0685
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0008 0.0026 0.0026
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0341 0.0341
Echinococcus multilocularis mitogen activated protein kinase 0.0019 0.0242 0.0242
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0341 0.0341
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0019 0.0242 0.0749
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0014 0.0134 0.0134
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0086 0.0086
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0024 0.0351 0.1285
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0034 0.0034
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0278 0.0926
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0128 0.0182
Echinococcus multilocularis raf serine:threonine protein kinase 0.0009 0.0034 0.0034
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0128 0.0475
Echinococcus granulosus mitogen activated protein kinase 3 0.0019 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0024 0.0341 0.0341
Brugia malayi Protein kinase domain containing protein 0.0156 0.3034 0.3034
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0024 0.0351 0.0351
Toxoplasma gondii thioredoxin reductase 0.0014 0.014 0.1794
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0019 0.0244 0.0758
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0128 0.0258
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0134
Brugia malayi hypothetical protein 0.0021 0.0278 0.0278
Echinococcus granulosus muscleblind protein 0.0055 0.0973 0.0973
Trypanosoma brucei glucosidase, putative 0.0013 0.0128 0.0458
Schistosoma mansoni 6-phosphofructokinase 0.004 0.0669 0.0669
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0278 0.1181
Loa Loa (eye worm) hypothetical protein 0.0008 0.0029 0.0029
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0052 0.0924 0.2198
Schistosoma mansoni jumonji/arid domain-containing protein 0.0022 0.0311 0.0311
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0011 0.0077 0.0028
Mycobacterium tuberculosis Probable reductase 0.0032 0.0502 0.1158
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0014 0.0134 0.0134
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0032 0.0502 0.1158
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0086 0.0086
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0341 0.0341
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0113 0.0113
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0024 0.0351 0.0351
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.1045 0.2498
Echinococcus granulosus mitogen activated protein kinase 0.0019 0.0242 0.0242
Echinococcus granulosus 6 phosphofructokinase 0.004 0.0669 0.0669
Onchocerca volvulus 0.0053 0.0942 0.2783
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0925 0.4125
Trichomonas vaginalis phosphofructokinase, putative 0.004 0.0669 0.3017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0107 0.2039 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0107 0.2039 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0107 0.2039 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0341 0.0829
Trichomonas vaginalis CMGC family protein kinase 0.0019 0.0242 0.0842
Echinococcus multilocularis lysosomal alpha glucosidase 0.006 0.1074 0.1074
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0341 0.0341
Mycobacterium ulcerans 6-phosphofructokinase 0.004 0.0669 0.157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0341 0.0341
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0341 0.0341
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0009 0.0041 0.0348
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0242 0.0242
Brugia malayi hypothetical protein 0.0013 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0013 0.0113 0.0113
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.004 0.0669 0.157
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0341 0.0341
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0341 0.0341
Schistosoma mansoni protein kinase C mu 0.006 0.1085 0.1085
Schistosoma mansoni microtubule-associated protein tau 0.0254 0.5009 0.5009
Schistosoma mansoni memapsin-2 (A01 family) 0.0114 0.2181 0.2181
Schistosoma mansoni 6-phosphofructokinase 0.004 0.0669 0.0669
Loa Loa (eye worm) hypothetical protein 0.0011 0.0086 0.0086
Echinococcus granulosus myotubularin protein 13 0.0008 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0055 0.0973 0.0973
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0019 0.0242 0.0749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0341 0.0341
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0091 0.007
Mycobacterium ulcerans hypothetical protein 0.0038 0.0633 0.1482
Giardia lamblia Fructose-bisphosphate aldolase 0.0107 0.2039 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0011 0.0077 0.1817
Brugia malayi nuclear hormone receptor 0.0024 0.0341 0.0341
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0011 0.0077 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0341 0.0341
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.003 0.0476 0.0476
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0032 0.0502 0.1158
Echinococcus granulosus bloom syndrome protein 0.0015 0.0165 0.0165
Brugia malayi jmjC domain containing protein 0.0022 0.0297 0.0297
Brugia malayi Pleckstrin Homology Domain 0.0008 0.0029 0.0029
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0341 0.0829
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0086 0.0086
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0341 0.0341
Brugia malayi steroid hormone receptor 0.0024 0.0341 0.0341
Echinococcus granulosus epidermal growth factor receptor 0.05 1 1
Entamoeba histolytica phosphofructokinase, putative 0.004 0.0669 0.3173
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0925 0.4291
Echinococcus multilocularis epidermal growth factor receptor 0.05 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0086 0.0086
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0013 0.0128 0.0128
Echinococcus multilocularis ubiquitin specific protease 41 0.0014 0.0134 0.0134
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.003 0.0476 0.0476
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0072 0.0651
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0019 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0031 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.0026 0.0386 0.0386
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0011 0.0077 1
Brugia malayi Bloom's syndrome protein homolog 0.0015 0.0165 0.0165
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0016 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0021 0.0278 0.0278
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0086 0.0086
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0024 0.0341 0.0341
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0086 0.0086
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0031 0.0478 0.0478
Schistosoma mansoni vav2 0.0008 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0341 0.0341
Brugia malayi Bromodomain containing protein 0.0028 0.0418 0.0418
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0024 0.0351 0.153
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0208 0.4087 1
Schistosoma mansoni alpha-glucosidase 0.0052 0.0905 0.0905
Brugia malayi C1-like domain containing protein 0.006 0.1085 0.1085
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0086 0.0086
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0024 0.0341 0.0341
Echinococcus granulosus insulin receptor 0.0156 0.3034 0.3034
Plasmodium falciparum thioredoxin reductase 0.0014 0.014 0.4388
Loa Loa (eye worm) hypothetical protein 0.0024 0.0341 0.0341
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0113 0.0113
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0341 0.0341
Giardia lamblia Kinase, CMGC MAPK 0.0019 0.0242 0.0868
Treponema pallidum fructose-bisphosphate aldolase 0.0107 0.2039 1
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0341 0.0341
Schistosoma mansoni tyrosine kinase 0.0331 0.6575 0.6575
Entamoeba histolytica phosphofructokinase, putative 0.004 0.0669 0.3173
Brugia malayi hypothetical protein 0.0163 0.3164 0.3164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0341 0.0341
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0052 0.0924 0.2198
Schistosoma mansoni hypothetical protein 0.0009 0.0046 0.0046
Loa Loa (eye worm) RecQ helicase 0.0015 0.0165 0.0165
Echinococcus multilocularis muscleblind protein 0.0055 0.0973 0.0973
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0022 0.0297 0.0297
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0341 0.0341
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0341 0.0341
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0633 0.1482
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0086 0.0086
Echinococcus granulosus ubiquitin specific protease 41 0.0014 0.0134 0.0134
Echinococcus multilocularis thioredoxin glutathione reductase 0.0014 0.0144 0.0144
Schistosoma mansoni jumonji domain containing protein 0.0022 0.0297 0.0297
Mycobacterium ulcerans hypothetical protein 0.0038 0.0633 0.1482
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0056 0.0056
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0086 0.0086
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.003 0.0476 0.0476
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0016 0.0175 0.0415
Brugia malayi nuclear hormone receptor 0.0011 0.0086 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0053 0.0942 0.0942
Brugia malayi hypothetical protein 0.0011 0.0086 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0134 0.029
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0035 0.0574 0.1335
Echinococcus multilocularis bloom syndrome protein 0.0015 0.0165 0.0165
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0341 0.0341
Echinococcus multilocularis Protein lozenge 0.002 0.0273 0.0273
Echinococcus multilocularis 0.0251 0.4951 0.4951
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0341 0.0341
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0086 0.0086
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.006 0.1074 0.1074
Echinococcus multilocularis L aminoadipate semialdehyde 0.0031 0.0478 0.0478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0341 0.0341
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0111 0.2112 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0162 0.0162
Leishmania major mitochondrial DNA polymerase beta 0.0111 0.2112 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0333 0.6616 0.6616
Brugia malayi tailless protein 0.0011 0.0086 0.0086
Plasmodium vivax 6-phosphofructokinase, putative 0.0011 0.0077 0.1817
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0019 0.0242 0.1009
Trichomonas vaginalis phosphofructokinase, putative 0.004 0.0669 0.3017
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0341 0.0341
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.006 0.1085 0.1085
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0019 0.0242 0.0749
Brugia malayi 6-phosphofructokinase 0.004 0.0669 0.0669
Brugia malayi jmjC domain containing protein 0.0022 0.0311 0.0311
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0128 0.0258
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0107 0.2039 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0072 0.0072
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0024 0.0351 0.0351
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.004 0.0669 0.2861
Loa Loa (eye worm) jmjC domain-containing protein 0.0022 0.0311 0.0311
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0035 0.0574 0.1335
Brugia malayi Bromodomain containing protein 0.0014 0.0144 0.0144
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0013 0.0126 0.0126
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0278 1
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.003 0.0476 0.0476
Brugia malayi ecdysone receptor 0.0011 0.0086 0.0086
Mycobacterium ulcerans hypothetical protein 0.0058 0.1045 0.2498
Loa Loa (eye worm) hypothetical protein 0.0163 0.3164 0.3164
Brugia malayi Glycosyl hydrolases family 31 protein 0.006 0.1074 0.1074
Schistosoma mansoni hypothetical protein 0.003 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0024 0.0341 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0341 0.0341
Echinococcus multilocularis lysine specific demethylase 5A 0.0022 0.0297 0.0297
Echinococcus granulosus epidermal growth factor receptor 0.0333 0.6616 0.6616
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0014 0.0134 0.0317
Schistosoma mansoni tyrosine kinase 0.0333 0.6616 0.6616
Loa Loa (eye worm) apoptosis regulator protein 0.003 0.0476 0.0476
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0086 0.0086
Brugia malayi phosphofructokinase 0.004 0.0669 0.0669
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0016 0.0175 0.0415
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0341 0.0341
Plasmodium vivax glutathione reductase, putative 0.0014 0.014 0.4388
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0113 0.0113
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0013 0.0128 0.1586
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0022 0.0303 0.0303
Onchocerca volvulus 0.006 0.1077 0.3221
Schistosoma mansoni tyrosine kinase 0.0331 0.6575 0.6575
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0341 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0341 0.0341
Brugia malayi nuclear receptor RXR 0.0011 0.0086 0.0086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0341 0.0341
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0013 0.0113 0.0113
Leishmania major hypothetical protein, conserved 0.0021 0.0278 0.1181
Loa Loa (eye worm) hypothetical protein 0.0011 0.0086 0.0086
Schistosoma mansoni jumonji/arid domain-containing protein 0.0022 0.0311 0.0311
Echinococcus multilocularis mitogen activated protein kinase 3 0.0019 0.0242 0.0242
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.003 0.0476 0.0476
Plasmodium falciparum glutathione reductase 0.0014 0.014 0.4388
Brugia malayi Muscleblind-like protein 0.0055 0.0973 0.0973
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.0208 0.4087 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0341 0.0341
Echinococcus granulosus lysine specific demethylase 5A 0.0022 0.0311 0.0311
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0341 0.0341
Schistosoma mansoni DNA helicase recq1 0.0011 0.0072 0.0072
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0052 0.0924 0.2198
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0011 0.0077 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0278 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0053 0.0925 0.4291
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0341 0.0341
Echinococcus granulosus raf serine:threonine protein kinase 0.0009 0.0034 0.0034
Brugia malayi conserved hypotetical protein 0.0011 0.0086 0.0086
Onchocerca volvulus 0.0062 0.1114 0.3339
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0341 0.0341
Schistosoma mansoni tyrosine kinase 0.0156 0.3034 0.3034
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0086 0.0086
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0341 0.0341
Loa Loa (eye worm) thioredoxin reductase 0.0014 0.014 0.014
Trichomonas vaginalis phosphofructokinase, putative 0.004 0.0669 0.3017
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0086 0.0086
Echinococcus multilocularis neutral alpha glucosidase AB 0.0013 0.0128 0.0128
Brugia malayi glutathione reductase 0.0014 0.014 0.014
Loa Loa (eye worm) CAMK/PKD protein kinase 0.006 0.1085 0.1085
Plasmodium vivax thioredoxin reductase, putative 0.0014 0.014 0.4388
Echinococcus multilocularis epidermal growth factor receptor 0.0333 0.6616 0.6616
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0128 0.0258
Loa Loa (eye worm) PHD-finger family protein 0.0008 0.0012 0.0012
Echinococcus multilocularis 6 phosphofructokinase 0.004 0.0669 0.0669
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0053 0.0942 0.0942
Loa Loa (eye worm) glutathione reductase 0.0014 0.014 0.014
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0011 0.0086 0.0086

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.02 nM Inhibition of EGFR kinase L861Q mutant (unknown origin) after 1.5 hrs by FRET-based Z'-Lyte assay ChEMBL. No reference
IC50 (binding) = 22.12 nM Inhibition of wild type EGFR kinase (unknown origin) after 1.5 hrs by FRET-based Z'-Lyte assay ChEMBL. No reference
IC50 (binding) = 41.59 nM Inhibition of EGFR kinase L858R mutant (unknown origin) after 1.5 hrs by FRET-based Z'-Lyte assay ChEMBL. No reference
IC50 (binding) = 50.85 nM Inhibition of EGFR kinase L858R/T790M double mutant (unknown origin) after 1.5 hrs by FRET-based Z'-Lyte assay ChEMBL. No reference
IC50 (binding) = 122.45 nM Inhibition of EGFR kinase T790M mutant (unknown origin) after 1.5 hrs by FRET-based Z'-Lyte assay ChEMBL. No reference
IC50 (functional) = 0.92 uM Cytotoxicity against human NCI-H1975 cells expressing EGFR kinase L858R/T790M double mutant after 72 hrs by MTS assay ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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