Detailed information for compound 1860066

Basic information

Technical information
  • TDR Targets ID: 1860066
  • Name: 2-bromo-N-(3-phenylprop-2-enylideneamino)benz amide
  • MW: 329.191 | Formula: C16H13BrN2O
  • H donors: 1 H acceptors: 1 LogP: 3.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1Br)N/N=C/C=C/c1ccccc1
  • InChi: 1S/C16H13BrN2O/c17-15-11-5-4-10-14(15)16(20)19-18-12-6-9-13-7-2-1-3-8-13/h1-12H,(H,19,20)/b9-6+,18-12+
  • InChiKey: HMZWHRIVBASEKA-PXYULHTISA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-bromo-N-[[(E)-3-phenylprop-2-enylidene]amino]benzamide
  • SMR000119650
  • CBDivE_005804
  • 2-Bromo-N'-[(E,2E)-3-phenyl-2-propenylidene]benzohydrazide
  • STK229706
  • 2-Bromo-benzoic acid (3-phenyl-allylidene)-hydrazide
  • BAS 00108850
  • MLS000122264

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major protein kinase, putative 0.0061 0.0664 0.8707
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0007 0.0011 0.0005
Echinococcus multilocularis calcium dependent protein kinase 0.0057 0.0612 0.0655
Echinococcus granulosus solute carrier family 22 0.0028 0.0265 0.0283
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0061 0.0664 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0265 0.0762
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0077 0.023
Treponema pallidum threonyl-tRNA synthetase 0.0011 0.0065 0.3127
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.006 0.0643 0.0687
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0077 0.0082
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0077 0.0263
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Brugia malayi nuclear hormone receptor 0.0012 0.0077 0.0263
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0199 0.2302 0.2463
Loa Loa (eye worm) major facilitator superfamily transporter 0.0028 0.0265 0.0904
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0077 0.0263
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0077 0.0082
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Trypanosoma brucei glucose transporter, putative 0.0062 0.0667 0.8747
Toxoplasma gondii protein kinase, putative 0.0562 0.6636 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0199 0.2302 0.3458
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0672 0.882
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0038 0.0381 0.5587
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0028 0.0265 0.3384
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0028 0.0265 0.5643
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.006 0.0643 0.0687
Loa Loa (eye worm) hypothetical protein 0.0048 0.0509 0.174
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0008 0.0028
Plasmodium falciparum hexose transporter 0.0199 0.2302 0.2294
Onchocerca volvulus 0.0286 0.3341 1
Echinococcus granulosus lysyl tRNA synthetase 0.0044 0.0461 0.0493
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0011 0.0065 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0049 0.0508
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0843 0.0902
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0221
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.006 0.0643 0.1897
Echinococcus granulosus solute carrier family 22 0.0028 0.0265 0.0283
Onchocerca volvulus 0.0036 0.0361 0.1081
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0008 0.0028
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0077 0.0082
Schistosoma mansoni microtubule-associated protein tau 0.079 0.9349 1
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0667 0.1969
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0077 0.0082
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0007 0.0011 0.0039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0008 0.0009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0263
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0077 0.0082
Brugia malayi lysyl-tRNA synthetase 0.0044 0.0461 0.1573
Onchocerca volvulus 0.0028 0.0265 0.0792
Trypanosoma brucei glucose transporter, putative 0.0062 0.0667 0.8747
Trypanosoma cruzi histidyl-tRNA synthetase 0.0007 0.0011 0.0005
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0077 0.0082
Toxoplasma gondii anticodon binding domain-containing protein 0.0007 0.0011 0.0001
Plasmodium falciparum calcium-dependent protein kinase 3 0.0061 0.0664 0.0654
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Trypanosoma brucei protein kinase, putative 0.0062 0.0672 0.882
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0077 0.0082
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0044 0.0461 0.5997
Brugia malayi hypothetical protein 0.0006 0.0008 0.0028
Treponema pallidum prolyl-tRNA synthetase 0.0021 0.0183 1
Echinococcus granulosus microtubule associated protein 2 0.079 0.9349 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0843 0.0902
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0843 0.0902
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0672 0.0719
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Onchocerca volvulus 0.0028 0.0265 0.0792
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0077 0.0263
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0199 0.2302 0.2463
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0077 0.0263
Loa Loa (eye worm) hypothetical protein 0.006 0.0643 0.2196
Chlamydia trachomatis histidine--tRNA ligase 0.0007 0.0011 0.0008
Onchocerca volvulus 0.0028 0.0265 0.0792
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0028 0.0265 0.6499
Plasmodium vivax threonine--tRNA ligase, putative 0.0011 0.0065 0.0054
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0021 0.0183 0.3815
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Schistosoma mansoni histidyl-tRNA synthetase 0.0007 0.0011 0.0012
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0007 0.0011 0.0014
Leishmania major glucose transporter/membrane transporter D2, putative 0.0062 0.0667 0.8747
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0077 0.0263
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0011 0.0065 0.0822
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0061 0.0664 0.071
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0664 0.071
Brugia malayi nuclear receptor RXR 0.0006 0.0008 0.0028
Plasmodium vivax sugar transporter, putative 0.0028 0.0265 0.0254
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0166 0.1909 0.2042
Treponema pallidum glycyl-tRNA synthetase 0.0007 0.0011 0.002
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0672 0.2296
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0061 0.0664 0.8707
Echinococcus granulosus histone acetyltransferase KAT2B 0.0161 0.1854 0.1983
Schistosoma mansoni lysyl-tRNA synthetase 0.0044 0.0461 0.0493
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0077 0.0082
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Schistosoma mansoni glycyl-tRNA synthetase 0.0011 0.0065 0.0069
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0513 0.0758
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0077 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0667 0.1969
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0077 0.023
Brugia malayi hypothetical protein 0.0028 0.0265 0.0904
Echinococcus multilocularis General substrate transporter 0.0171 0.1969 0.2106
Trypanosoma cruzi sugar transporter, putative 0.0028 0.0265 0.3384
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0199 0.2302 0.2463
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0077 0.0082
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Loa Loa (eye worm) hypothetical protein 0.0044 0.0461 0.1573
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0007 0.0011 0.0001
Plasmodium vivax CDK-related protein kinase 6, putative 0.0845 1 1
Echinococcus granulosus histidyl tRNA synthetase 0.0007 0.0011 0.0012
Onchocerca volvulus 0.0028 0.0265 0.0792
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0011 0.0065 0.0221
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Trichomonas vaginalis myo-inositol transporter, putative 0.0028 0.0265 0.0762
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2927 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0265 0.0762
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0077 0.0082
Plasmodium vivax hexose transporter 0.0199 0.2302 0.2294
Plasmodium vivax proline--tRNA ligase, putative 0.007 0.076 0.075
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0011 0.0012
Echinococcus granulosus solute carrier family 22 0.0028 0.0265 0.0283
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0077 0.0263
Echinococcus multilocularis solute carrier family 22 0.0028 0.0265 0.0283
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0049 0.0114
Trypanosoma cruzi glucose transporter, putative 0.0028 0.0265 0.3384
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0265 0.0762
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0077 0.0263
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3341 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0672 0.882
Mycobacterium ulcerans hypothetical protein 0.001 0.0049 0.0848
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0061 0.0664 0.0986
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0011 0.0012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0077 0.0263
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0011 0.0012
Toxoplasma gondii transporter, major facilitator family protein 0.0028 0.0265 0.0383
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0513 0.1507
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0513 0.1507
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0345 0.0369
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0011 0.0065 0.0221
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0077 0.0082
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0077 0.0082
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0263
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0077 0.0082
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0007 0.0011 0.0012
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.006 0.0643 0.0687
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.0049 0.0508
Echinococcus multilocularis calcium activated potassium channel 0.0008 0.0027 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0263
Trichomonas vaginalis glucose transporter, putative 0.0028 0.0265 0.0762
Plasmodium falciparum protein kinase 7 0.0562 0.6636 0.6632
Leishmania major myo-inositol/proton symporter (MIT) 0.0028 0.0265 0.3384
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0672 0.1985
Onchocerca volvulus 0.0012 0.0077 0.023
Trypanosoma brucei glucose transporter, putative 0.0062 0.0667 0.8747
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0077 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0077 0.0263
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.007 0.076 0.1131
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0465 0.695
Loa Loa (eye worm) major facilitator superfamily transporter 0.0028 0.0265 0.0904
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Leishmania major glucose transporter, lmgt2 0.0062 0.0667 0.8747
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0028
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Mycobacterium ulcerans integral membrane transport protein 0.0028 0.0265 0.5643
Entamoeba histolytica hypothetical protein 0.0044 0.0461 0.6888
Brugia malayi Sugar transporter family protein 0.0199 0.2302 0.7865
Toxoplasma gondii sugar transporter ST3 0.0028 0.0265 0.0383
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0011 0.0012
Giardia lamblia Hexose transporter 0.0028 0.0265 0.3837
Trypanosoma cruzi hexose transporter, putative 0.0062 0.0667 0.8747
Toxoplasma gondii lysine-tRNA ligase 0.0044 0.0461 0.0678
Onchocerca volvulus 0.0028 0.0265 0.0792
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0263
Schistosoma mansoni protein kinase 0.0061 0.0664 0.071
Trypanosoma brucei glucose transporter, putative 0.0062 0.0667 0.8747
Trypanosoma brucei glucose transporter, putative 0.0062 0.0667 0.8747
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.2302 0.688
Trypanosoma cruzi hexose transporter, putative 0.0028 0.0265 0.3384
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0077 0.0263
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0672 0.882
Plasmodium vivax SET domain protein, putative 0.0036 0.0361 0.035
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0044 0.0461 0.135
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.0049 0.0508
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0672 1
Chlamydia trachomatis lysine--tRNA ligase 0.0044 0.0461 1
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Onchocerca volvulus 0.0028 0.0265 0.0792
Echinococcus granulosus Threonyl tRNA synthetase C 0.0011 0.0065 0.0069
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0199 0.2302 0.2463
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0061 0.0664 0.2267
Brugia malayi glycyl-tRNA synthetase 0.0011 0.0065 0.0221
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0011 0.0065 0.0715
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0077 0.0263
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0038 0.0381 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.006 0.0643 0.0687
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.007 0.076 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0361 0.0386
Onchocerca volvulus 0.0028 0.0265 0.0792
Leishmania major lysyl-tRNA synthetase, putative 0.0044 0.0461 0.5997
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0843 0.0902
Schistosoma mansoni sugar transporter 0.0028 0.0265 0.0283
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0843 0.2881
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.001 0.0049 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0077 0.0263
Plasmodium falciparum calcium-dependent protein kinase 4 0.0061 0.0664 0.0654
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.0049 0.0508
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0077 0.0263
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0077 0.0082
Loa Loa (eye worm) sugar transporter 0.0028 0.0265 0.0904
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0361 0.0386
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0061 0.0664 0.2267
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0265 0.0762
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0077 0.0082
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0672 0.882
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0061 0.0664 0.0986
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0077 0.0082
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0011 0.0065 0.1193
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0007 0.0011 0.0038
Brugia malayi Pre-SET motif family protein 0.0036 0.0361 0.1234
Schistosoma mansoni lysyl-tRNA synthetase 0.0044 0.0461 0.0493
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0011 0.0065 0.0715
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0061 0.0664 0.0986
Giardia lamblia Glycyl-tRNA synthetase 0.0011 0.0065 0.0811
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0672 0.0998
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0011 0.0012
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0007 0.0011 0.0008
Echinococcus multilocularis solute carrier family 22 0.0028 0.0265 0.0283
Toxoplasma gondii sugar transporter ST1 0.0028 0.0265 0.0383
Chlamydia trachomatis threonine--tRNA ligase 0.0011 0.0065 0.1193
Plasmodium falciparum lysine--tRNA ligase 0.0044 0.0461 0.045
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0007 0.0011 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0664 0.196
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0077 0.0082
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0166 0.1909 0.2042
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0265 0.0762
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0028 0.0265 0.6499
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0077 0.0082
Echinococcus multilocularis solute carrier family 22 0.0028 0.0265 0.0283
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0077 0.0263
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0672 0.0719
Loa Loa (eye worm) hypothetical protein 0.0061 0.0664 0.2267
Schistosoma mansoni histidyl-tRNA synthetase 0.0007 0.0011 0.0012
Brugia malayi Pre-SET motif family protein 0.0251 0.2927 1
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0333 0.4299
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0024 0.0223 0.0763
Trichomonas vaginalis sugar transport protein, putative 0.0028 0.0265 0.0762
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0322 0.3769 0.5672
Echinococcus multilocularis microtubule associated protein 2 0.079 0.9349 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0843 0.2881
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0007 0.0011 0.0005
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.007 0.076 1
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0011 0.0065 0.0715
Brugia malayi TAR-binding protein 0.0076 0.0843 0.2881
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0028 0.0265 0.5643
Trypanosoma brucei histidyl-tRNA synthetase 0.0007 0.0011 0.0005
Brugia malayi Sugar transporter family protein 0.0028 0.0265 0.0904
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0077 0.0082
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0077 0.0082
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0843 0.2881
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0667 0.1969
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Plasmodium falciparum mitogen-activated protein kinase 2 0.0322 0.3769 0.3762
Schistosoma mansoni glucose transport protein 0.0199 0.2302 0.2463
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Brugia malayi Aspartyl-tRNA synthetase 0.0007 0.0011 0.0038
Brugia malayi hypothetical protein 0.0028 0.0265 0.0904
Loa Loa (eye worm) acetyltransferase 0.0166 0.1909 0.6523
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0361 0.0386
Mycobacterium ulcerans sugar transporter 0.0028 0.0265 0.5643
Trypanosoma brucei THT1 - hexose transporter, putative 0.0062 0.0667 0.8747
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0008 0.0009
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.006 0.0643 0.2196
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0077 0.0082
Echinococcus granulosus calcium dependent protein kinase 0.0057 0.0612 0.0655
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0061 0.0664 0.071
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0672 0.0719
Trypanosoma brucei THT1 - hexose transporter, putative 0.0062 0.0667 0.8747
Schistosoma mansoni glucose transport protein 0.0199 0.2302 0.2463
Leishmania major hypothetical protein, conserved 0.001 0.0049 0.0508
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0011 0.0065 0.0715
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0672 0.0719
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0077 0.0263
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0667 0.1969
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0011 0.0065 0.2114
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0077 0.0263
Brugia malayi major facilitator superfamily protein 0.0028 0.0265 0.0904
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0263
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0513 0.0549
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0199 0.2302 0.2463
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0028
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0011 0.0065 0.0069
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0061 0.0664 0.071
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0011 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0077 0.0082
Plasmodium falciparum calcium-dependent protein kinase 5 0.0061 0.0664 0.0654
Echinococcus multilocularis histidyl tRNA synthetase 0.0007 0.0011 0.0012
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Trichomonas vaginalis sugar transporter, putative 0.0062 0.0667 0.1969
Loa Loa (eye worm) hypothetical protein 0.0036 0.0361 0.1234
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0061 0.0664 0.071
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0061 0.0664 0.2267
Onchocerca volvulus Putative transporter 0.0028 0.0265 0.0792
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0077 0.0263
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0044 0.0461 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0077 0.0263
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0077 0.0082
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Giardia lamblia Threonyl-tRNA synthetase 0.0011 0.0065 0.0811
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Schistosoma mansoni hypothetical protein 0.0199 0.2302 0.2463
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Schistosoma mansoni glucose transporter 0.0028 0.0265 0.0283
Leishmania major hypothetical protein, conserved 0.0028 0.0265 0.3384
Schistosoma mansoni glucose transport protein 0.0199 0.2302 0.2463
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0513 0.0758
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0843 0.0902
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0061 0.0664 0.071
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0322 0.3769 0.3762
Echinococcus granulosus tar DNA binding protein 0.0076 0.0843 0.0902
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0007 0.0011 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0077 0.0263
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0077 0.0082
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0672 0.882
Brugia malayi Sugar transporter family protein 0.0028 0.0265 0.0904
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0028
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0011 0.0065 0.0221
Plasmodium vivax lysine--tRNA ligase, putative 0.0044 0.0461 0.045
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Onchocerca volvulus 0.0028 0.0265 0.0792
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0061 0.0664 0.071
Leishmania major hypothetical protein, conserved 0.001 0.0049 0.0508
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0672 0.1985
Trypanosoma cruzi hexose transporter, putative 0.0062 0.0667 0.8747
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0672 0.1985
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0199 0.2302 0.2463
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0011 0.0065 0.0081
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0672 0.882
Brugia malayi steroid hormone receptor 0.0012 0.0077 0.0263
Trichomonas vaginalis glucose transporter, putative 0.0062 0.0667 0.1969
Trichomonas vaginalis glucose transporter, putative 0.0062 0.0667 0.1969
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0672 0.882
Loa Loa (eye worm) sugar transporter 0.0199 0.2302 0.7865
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0077 0.0263
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0077 0.023
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0077 0.0263
Trypanosoma brucei glucose transporter, putative 0.0062 0.0667 0.8747
Trypanosoma brucei glucose transporter, putative 0.0062 0.0667 0.8747
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0011 0.0065 0.0221
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0263
Onchocerca volvulus 0.0028 0.0265 0.0792
Echinococcus granulosus General substrate transporter 0.0171 0.1969 0.2106
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Brugia malayi ecdysteroid receptor 0.0012 0.0077 0.0263
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0007 0.0011 0.0038
Toxoplasma gondii glycyl-tRNA synthetase 0.0011 0.0065 0.0081
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.006 0.0643 0.9678
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0077 0.0263
Echinococcus granulosus solute carrier family 22 0.0028 0.0265 0.0283
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0044 0.0461 0.6932
Schistosoma mansoni protein kinase 0.0061 0.0664 0.071
Brugia malayi MAP kinase sur-1 0.0062 0.0672 0.2296
Trypanosoma brucei glucose transporter 1E 0.0062 0.0667 0.8747
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0361 0.0386
Schistosoma mansoni sugar transporter 0.0028 0.0265 0.0283
Brugia malayi Major Facilitator Superfamily protein 0.0028 0.0265 0.0904
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0061 0.0664 0.0654
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0843 0.0902
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0361 0.0528
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0361 0.0386
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0007 0.0011 0.0005
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0028 0.0265 0.0254
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0077 0.0082
Plasmodium vivax glycine--tRNA ligase, putative 0.0011 0.0065 0.0054
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0007 0.0011 0.0012
Echinococcus multilocularis synaptic vesicle 2 protein 0.0028 0.0265 0.0283
Brugia malayi acetyltransferase, GNAT family protein 0.0166 0.1909 0.6523
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0077 0.0263
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0028 0.0265 0.0283
Echinococcus granulosus calcium activated potassium channel 0.0008 0.0027 0.0029
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0028
Entamoeba histolytica protein kinase, putative 0.0061 0.0664 1
Onchocerca volvulus 0.0028 0.0265 0.0792
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Plasmodium vivax calcium-dependent protein kinase, putative 0.0061 0.0664 0.0654
Brugia malayi hypothetical protein 0.0028 0.0265 0.0904
Plasmodium falciparum calcium-dependent protein kinase 2 0.0061 0.0664 0.0654
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0044 0.0461 1
Onchocerca volvulus 0.0028 0.0265 0.0792
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0011 0.0012
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0007 0.0011 0.0012
Onchocerca volvulus 0.0028 0.0265 0.0792
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.007 0.076 1
Onchocerca volvulus 0.0028 0.0265 0.0792
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Plasmodium falciparum proline--tRNA ligase 0.007 0.076 0.075
Echinococcus multilocularis lysyl tRNA synthetase 0.0044 0.0461 0.0493
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0049 0.0508
Leishmania major histidyl-tRNA synthetase, putative 0.0007 0.0011 0.0005
Onchocerca volvulus 0.0028 0.0265 0.0792
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0011 0.0065 0.1193
Loa Loa (eye worm) 63kd antigen 0.0007 0.0011 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Onchocerca volvulus 0.0028 0.0265 0.0792
Brugia malayi RNA binding protein 0.0076 0.0843 0.2881
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0077 0.0082
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0199 0.2302 0.2463
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0039 0.0395 0.1154
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.007 0.076 1
Trypanosoma brucei sugar transporter, putative 0.0028 0.0265 0.3384
Schistosoma mansoni protein kinase 0.0061 0.0664 0.071
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.007 0.076 1
Leishmania major glycyl tRNA synthetase, putative 0.0007 0.0011 0.0005
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0465 0.0454
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0465 0.6861
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0007 0.0011 0.0001
Chlamydia trachomatis proline--tRNA ligase 0.0021 0.0183 0.3815
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0028 0.0265 0.0283
Giardia lamblia Prolyl-tRNA synthetase 0.006 0.0643 0.9555
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0061 0.0664 0.071
Trypanosoma brucei THT1 - hexose transporter, putative 0.0062 0.0667 0.8747
Echinococcus granulosus Sugar transporter ERD6 protein 0.0028 0.0265 0.0283
Giardia lamblia Lysyl-tRNA synthetase 0.0044 0.0461 0.68
Trypanosoma cruzi hexose transporter 0.0062 0.0667 0.8747
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0077 0.0082
Echinococcus granulosus synaptic vesicle 2 protein 0.0028 0.0265 0.0283
Leishmania major glucose transporter, lmgt3 0.0062 0.0667 0.8747
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0049 0.0114
Schistosoma mansoni coup transcription factor 0.0012 0.0077 0.0082
Entamoeba histolytica protein kinase, putative 0.0061 0.0664 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0061 0.0664 0.0654
Plasmodium falciparum threonine--tRNA ligase 0.0011 0.0065 0.0054
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0007 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0028
Toxoplasma gondii sugar transporter ST2 0.0028 0.0265 0.0383
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0061 0.0664 0.071
Echinococcus granulosus glycyl tRNA synthetase 0.0011 0.0065 0.0069
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Echinococcus multilocularis solute carrier family 22 0.0028 0.0265 0.0283
Leishmania major glucose transporter, lmgt1 0.0062 0.0667 0.8747
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0077 0.0263
Leishmania major threonyl-tRNA synthetase, putative 0.0011 0.0065 0.0715
Schistosoma mansoni sugar transporter 0.0028 0.0265 0.0283
Brugia malayi nuclear receptor NHR-88 0.0012 0.0077 0.0263
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0061 0.0664 0.0654
Brugia malayi Cam kinase protein 1 0.0061 0.0664 0.2267
Echinococcus multilocularis glycyl tRNA synthetase 0.0011 0.0065 0.0069
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0008 0.0028
Giardia lamblia Sugar-proton symporter 0.0028 0.0265 0.3837
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0361 0.0386
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0008 0.0009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0077 0.0082
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0011 0.0065 0.0468
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0007 0.0011 0.0001
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0672 0.0719
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0011 0.0065 0.2114
Brugia malayi Major Facilitator Superfamily protein 0.0028 0.0265 0.0904
Brugia malayi major facilitator superfamily protein 0.0028 0.0265 0.0904
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0011 0.0065 0.0262
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0672 0.1985
Brugia malayi Major Facilitator Superfamily protein 0.0028 0.0265 0.0904
Onchocerca volvulus 0.0028 0.0265 0.0792
Loa Loa (eye worm) hypothetical protein 0.006 0.0643 0.2196
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0028 0.0265 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.0843 0.2881
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0044 0.0461 0.5997
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0008 0.0009
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0513 0.0502
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0199 0.2302 0.2463
Schistosoma mansoni threonyl-tRNA synthetase 0.0007 0.0011 0.0012
Trypanosoma brucei glucose transporter, putative 0.0062 0.0667 0.8747
Trypanosoma brucei glucose transporter 2A 0.0062 0.0667 0.8747
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0904
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0263
Brugia malayi hypothetical protein 0.0006 0.0008 0.0028
Schistosoma mansoni sugar transporter 0.0028 0.0265 0.0283
Trypanosoma cruzi hexose transporter, putative 0.0062 0.0667 0.8747
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0011 0.0065 0.0822
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0049 0.0114
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0038 0.0381 1
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.006 0.0643 1
Trichomonas vaginalis sugar transporter, putative 0.0028 0.0265 0.0762
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.006 0.0643 0.2196
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0007 0.0011 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0361 0.0386

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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