Detailed information for compound 1864273

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 890.053 | Formula: C46H59N5O11S
  • H donors: 7 H acceptors: 9 LogP: 0.6 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 3
  • SMILES: OS(=O)(=O)O.C#CCNC(=O)[C@@]1(O)[C@H](O)[C@]2(CC)C=CCN3[C@@H]2[C@@]2([C@H]1N(C)c1c2cc(c(c1)OC)[C@]1(C[C@@H]2CN(CCc4c1[nH]c1c4cccc1)C[C@](C2)(O)CC)C(=O)OC)CC3
  • InChi: 1S/C46H57N5O7.H2O4S/c1-7-18-47-40(53)46(56)38-44(17-21-51-19-12-16-43(9-3,37(44)51)39(46)52)31-22-32(35(57-5)23-34(31)49(38)4)45(41(54)58-6)25-28-24-42(55,8-2)27-50(26-28)20-15-30-29-13-10-11-14-33(29)48-36(30)45;1-5(2,3)4/h1,10-14,16,22-23,28,37-39,48,52,55-56H,8-9,15,17-21,24-27H2,2-6H3,(H,47,53);(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
  • InChiKey: FSAMPWNLKFEDMT-JKDPCDLQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Trypanosoma cruzi small ubiquitin protein, putative 0.0032 0.0031 0.0123
Onchocerca volvulus 0.0039 0.0094 0.0642
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0039 0.0094 0.045
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Plasmodium falciparum small ubiquitin-related modifier 0.0032 0.0031 0.1614
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0033 0.004 0.0076
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0033 0.004 0.0161
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0277 0.1105
Echinococcus multilocularis 0.0039 0.0094 0.045
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.014 0.0109
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Leishmania major hypothetical protein, conserved 0.006 0.0277 0.0994
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0039 0.0094 0.0175
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.014 0.0261
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0267 0.2079 0.3879
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0053 0.0252
Onchocerca volvulus 0.0039 0.0094 0.0642
Loa Loa (eye worm) acetyltransferase 0.0152 0.1074 0.4452
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0094 0.0175
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0316 0.2508 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0039 0.0094 0.0177
Onchocerca volvulus 0.0039 0.0094 0.0642
Trichomonas vaginalis glutaminase, putative 0.0305 0.2413 0.2389
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0267 0.2079 0.8618
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0039 0.0094 0.0388
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0039 0.0094 0.0374
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.1056 0.4137
Brugia malayi jmjC domain containing protein 0.0035 0.0053 0.0217
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0139 0.0552
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0039 0.0094 0.045
Onchocerca volvulus 0.0039 0.0094 0.0642
Onchocerca volvulus 0.0039 0.0094 0.0642
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0033 0.004 0.0075
Toxoplasma gondii ThiF family protein 0.0033 0.004 0.2062
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0039 0.0094 0.045
Toxoplasma gondii hypothetical protein 0.0051 0.0196 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0033 0.004 0.2112
Brugia malayi hypothetical protein 0.0039 0.0094 0.0388
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0267 0.2079 0.3926
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0196 0.0943
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.1074 0.4452
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.1174 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0039 0.0094 0.0175
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0267 0.2079 0.3879
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0039 0.0094 0.0177
Brugia malayi hypothetical protein 0.0039 0.0094 0.0388
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Toxoplasma gondii hypothetical protein 0.005 0.0191 0.9764
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0039 0.0094 0.045
Schistosoma mansoni hypothetical protein 0.0177 0.1298 0.2451
Toxoplasma gondii small ubiquitin family modifier, putative 0.0032 0.0031 0.1575
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Giardia lamblia Sentrin 0.0032 0.0031 0.0211
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0196 0.0943
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Onchocerca volvulus 4.1 G protein, putative homolog 0.0039 0.0094 0.0642
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0094 0.0175
Schistosoma mansoni sumo-1-activating enzyme E1a 0.005 0.0191 0.036
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0039 0.0094 0.0175
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0196 0.0813
Onchocerca volvulus 0.0039 0.0094 0.0642
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0039 0.0094 0.0177
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0039 0.0094 0.0388
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0033 0.004 0.0038
Brugia malayi jmjC domain containing protein 0.0094 0.0567 0.2351
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0196 0.037
Giardia lamblia Protein tyrosine phosphatase 0.0039 0.0094 0.0642
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0094 0.045
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1056 0.4209
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0196 0.1459 0.1432
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0039 0.0094 0.0177
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0039 0.0094 0.045
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0039 0.0094 0.0388
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0094 0.0175
Echinococcus multilocularis hypothetical protein 0.0039 0.0094 0.045
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0039 0.0094 0.0388
Onchocerca volvulus 0.0039 0.0094 0.0642
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Loa Loa (eye worm) hypothetical protein 0.005 0.0191 0.0791
Trichomonas vaginalis pten, drome, putative 0.0039 0.0094 0.0063
Leishmania major tyrosine specific protein phosphatase, putative 0.0039 0.0094 0.0254
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0196 0.0366
Onchocerca volvulus 0.0039 0.0094 0.0642
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0039 0.0094 0.045
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0053 0.0099
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0098 0.047
Echinococcus granulosus jumonji domain containing protein 0.004 0.0098 0.0182
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0094 0.045
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.005 0.0191 0.0918
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0039 0.0094 0.0374
Brugia malayi hypothetical protein 0.0039 0.0094 0.0388
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Schistosoma mansoni protein tyrosine phosphatase 0.0039 0.0094 0.0177
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.1074 0.2028
Loa Loa (eye worm) ThiF family protein 0.0033 0.004 0.0167
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0094 0.045
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0039 0.0094 0.045
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.2508 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Echinococcus granulosus geminin 0.0177 0.1298 0.2421
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0094 0.045
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0039 0.0094 0.045
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0039 0.0094 0.0175
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0039 0.0094 0.0177
Onchocerca volvulus 0.0039 0.0094 0.0642
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.2508 1
Onchocerca volvulus 0.0039 0.0094 0.0642
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0196 0.1459 0.6045
Onchocerca volvulus 0.0039 0.0094 0.0642
Echinococcus granulosus Small ubiquitin modifier 2 0.0032 0.0031 0.0057
Onchocerca volvulus 0.0039 0.0094 0.0642
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Onchocerca volvulus 0.0039 0.0094 0.0642
Plasmodium vivax small ubiquitin-related modifier, putative 0.0032 0.0031 0.1614
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0567 0.2728
Loa Loa (eye worm) SMO-1 protein 0.0032 0.0031 0.0128
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0032 0.0031 0.0058
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0039 0.0094 0.0177
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0196 0.1459 0.0624
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0094 0.045
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0108 0.563
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0267 0.2079 0.8618
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0108 0.0737
Mycobacterium ulcerans glutaminase 0.0305 0.2413 0.2956
Echinococcus multilocularis peregrin 0.0032 0.0033 0.0156
Leishmania major mitochondrial DNA polymerase beta 0.0316 0.2508 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0039 0.0094 0.045
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0039 0.0094 0.0177
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0277 0.1105
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0635 0.5295 0.5
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.006 0.0277 0.0247
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0039 0.0094 0.0175
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0642 0.536 1
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0635 0.5295 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0039 0.0094 0.0063
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0053 0.0098
Brugia malayi hypothetical protein 0.0039 0.0094 0.0388
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0635 0.5295 0.5
Onchocerca volvulus 0.0039 0.0094 0.0642
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0039 0.0094 0.0063
Onchocerca volvulus 0.0039 0.0094 0.0642
Echinococcus granulosus peregrin 0.0032 0.0033 0.006
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Brugia malayi glutaminase DH11.1 0.0305 0.2413 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.014 0.0109
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0196 0.1459 0.1432
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.0635 0.5295 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.1203 0.0621
Trypanosoma brucei protein tyrosine phosphatase 1 0.0039 0.0094 0.0254
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0196 0.1459 0.6045
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Echinococcus multilocularis geminin 0.0177 0.1298 0.6242
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0267 0.2079 1
Onchocerca volvulus 0.0196 0.1459 1
Treponema pallidum replicative DNA helicase (dnaB) 0.0635 0.5295 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.014 0.7156
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Plasmodium vivax ubiquitin activating enzyme, putative 0.005 0.0191 1
Schistosoma mansoni protein tyrosine phosphatase 0.0039 0.0094 0.0177
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0196 0.1459 0.1432
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0039 0.0094 0.0177
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0039 0.0094 0.0175
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0094 0.0175
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0094 0.0175
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0039 0.0094 0.0177
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Leishmania major ubiquitin-activating enzyme-like protein 0.0033 0.004 0.0038
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0053 0.0099
Schistosoma mansoni protein tyrosine phosphatase 0.0039 0.0094 0.0177
Echinococcus multilocularis Small ubiquitin modifier 2 0.0032 0.0031 0.0148
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0039 0.0094 0.0254
Brugia malayi Bromodomain containing protein 0.0032 0.0033 0.0134
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Schistosoma mansoni Replicative DNA helicase 0.0635 0.5295 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0039 0.0094 0.0175
Brugia malayi Ubiquitin-like protein SMT3 0.0032 0.0031 0.0128
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0094 0.0175
Onchocerca volvulus 0.0039 0.0094 0.0642
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0399 0.0754
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.006 0.0277 0.0247
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0266 0.11
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0223 0.0891
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0094 0.045
Loa Loa (eye worm) glutaminase 0.0305 0.2413 1
Brugia malayi Protein-tyrosine phosphatase 1 0.0039 0.0094 0.0388
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.1074 0.5166
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0053 0.0217
Brugia malayi ThiF family protein 0.0033 0.004 0.0167
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.006 0.0277 0.0994
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0039 0.0094 0.0374
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Schistosoma mansoni hypothetical protein 0.0177 0.1298 0.2451
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0267 0.2079 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0196 0.037
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0196 0.1459 0.1432
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0196 0.1459 1
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0039 0.0094 0.045
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0039 0.0094 0.0177
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0108 0.0077
Brugia malayi hypothetical protein 0.0039 0.0094 0.0388
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0033 0.004 0.0194
Onchocerca volvulus 0.0039 0.0094 0.0642
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0039 0.0094 0.0177
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0196 0.1459 0.1432
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Onchocerca volvulus 0.0039 0.0094 0.0642
Schistosoma mansoni glutaminase 0.0305 0.2413 0.4556
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0033 0.004 0.2112
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.014 0.7156
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0196 0.1459 0.1432
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0039 0.0094 0.0388
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0196 0.0813
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0039 0.0094 0.0388
Onchocerca volvulus 0.0039 0.0094 0.0642
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0039 0.0094 0.0063
Loa Loa (eye worm) twinkle helicase 0.0181 0.1335 0.5533
Schistosoma mansoni pcd6 interacting protein-related 0.0039 0.0094 0.0177
Trypanosoma cruzi small ubiquitin protein, putative 0.0032 0.0031 0.0123
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0039 0.0094 0.045
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0139 0.0434
Onchocerca volvulus 0.0039 0.0094 0.0642
Echinococcus granulosus SUMO activating enzyme subunit 1 0.005 0.0191 0.0356
Chlamydia trachomatis replicative DNA helicase 0.0635 0.5295 0.5
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0039 0.0094 0.0177
Loa Loa (eye worm) glutaminase 2 0.0305 0.2413 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0039 0.0094 0.045
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.1056 0.4137
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Onchocerca volvulus 0.0039 0.0094 0.0642
Onchocerca volvulus 0.0039 0.0094 0.0642
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0039 0.0094 0.0177
Echinococcus granulosus protein tyrosine phosphatase n9 0.0039 0.0094 0.0175
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0196 0.1459 0.1432
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0094 0.0175
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0196 0.037
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0567 0.1058
Loa Loa (eye worm) hypothetical protein 0.0049 0.0178 0.0738
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0139 0.0552
Brugia malayi Protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Onchocerca volvulus 0.0039 0.0094 0.0642
Loa Loa (eye worm) protein tyrosine phosphatase 0.0039 0.0094 0.0388
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0039 0.0094 0.045
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0039 0.0094 0.045
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0196 0.1459 0.1432
Brugia malayi ThiF family protein 0.005 0.0191 0.0791
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.1037 0.1934
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0046 0.0151 0.0284
Brugia malayi Protein-tyrosine phosphatase 0.0039 0.0094 0.0388
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0094 0.0175
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0039 0.0094 0.0177
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0196 0.0366
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0094 0.0388
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0139 0.0552
Loa Loa (eye worm) hypothetical protein 0.0039 0.0094 0.0388
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.014 0.7329
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.005 0.0191 1

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) Toxicity in C3H mouse allografted with mouse Gardner lymphosarcoma assessed as lethality at 0.40 mg/kg, ip administered daily for 8 to 10 days ChEMBL. 430477

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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