Detailed information for compound 1899226

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 339.342 | Formula: C19H17NO5
  • H donors: 3 H acceptors: 3 LogP: 3.71 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(O)ccc2c1[nH]c1c3C=CC(Oc3cc(c1c2=O)O)(C)C
  • InChi: 1S/C19H17NO5/c1-19(2)7-6-9-13(25-19)8-12(22)14-15(9)20-16-10(17(14)23)4-5-11(21)18(16)24-3/h4-8,21-22H,1-3H3,(H,20,23)
  • InChiKey: COUZVMMRGYONAQ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 9 Starlite/ChEMBL References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 Starlite/ChEMBL References
Homo sapiens CDC-like kinase 1 Starlite/ChEMBL References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References
Homo sapiens CDC-like kinase 2 Starlite/ChEMBL References
Homo sapiens cyclin T1 References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 alpha References
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References
Homo sapiens CDC-like kinase 3 Starlite/ChEMBL References
Homo sapiens dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B Starlite/ChEMBL References
Homo sapiens cyclin A2 Starlite/ChEMBL References
Mus musculus CDC-like kinase 1 Starlite/ChEMBL References
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Starlite/ChEMBL References
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02211 cyclin-dependent kinase 9, putative Get druggable targets OG5_130531 All targets in OG5_130531
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 Get druggable targets OG5_127439 All targets in OG5_127439
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans CDC2-related protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana protein kinase-like protein Get druggable targets OG5_127439 All targets in OG5_127439
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_130531 All targets in OG5_130531
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania donovani dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC DYRK Get druggable targets OG5_127439 All targets in OG5_127439
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative Get druggable targets OG5_127439 All targets in OG5_127439
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02211 cyclin-dependent kinase 9, putative Get druggable targets OG5_130531 All targets in OG5_130531
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans similar ot C terminus of S. cerevisiae SGV1 (YPR161C) Get druggable targets OG5_130531 All targets in OG5_130531
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi cyclin-dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus multilocularis cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum hypothetical protein Get druggable targets OG5_127439 All targets in OG5_127439
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania infantum protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130531 All targets in OG5_130531
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni kinase Get druggable targets OG5_130531 All targets in OG5_130531
Candida albicans weaker similarity to S. cerevisiae YAK1 (YJL141C) Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans weaker similarity to S. cerevisiae YAK1 (YJL141C) Get druggable targets OG5_127439 All targets in OG5_127439
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131337 All targets in OG5_131337
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_127439 All targets in OG5_127439
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08825 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Echinococcus granulosus cyclin dependent kinase 9 Get druggable targets OG5_130531 All targets in OG5_130531
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus dual specificity Get druggable targets OG5_127439 All targets in OG5_127439
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis protein kinase, putative,dual-specificity protein kinase, putative Get druggable targets OG5_127439 All targets in OG5_127439
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 9 372 aa 313 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.037 1 1
Trypanosoma cruzi cdc2-related kinase 3 0.0111 0.2293 0.2003
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0123 0.2645 0.2369
Loa Loa (eye worm) hypothetical protein 0.0362 0.9757 0.9748
Giardia lamblia Kinase, CMGC DYRK 0.0135 0.3013 0.2751
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.2293 0.2293
Giardia lamblia Kinase, CMGC CDK 0.0111 0.2293 0.2003
Trichomonas vaginalis cyclins, putative 0.0046 0.0363 0.0363
Leishmania major protein kinase, putative 0.037 1 1
Echinococcus granulosus cyclin dependent kinase 5 0.0111 0.2293 0.2003
Entamoeba histolytica protein kinase domain containing protein 0.0123 0.2645 0.2709
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0123 0.2645 0.2369
Trichomonas vaginalis cyclins, putative 0.0046 0.0363 0.0363
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0123 0.2645 0.2369
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.2293 0.2293
Echinococcus granulosus dual specificity 0.033 0.8791 0.8746
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.037 1 1
Echinococcus multilocularis cyclin dependent kinase 9 0.0062 0.0839 0.0494
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0135 0.3013 0.2751
Echinococcus granulosus protein kinase shaggy 0.0123 0.2645 0.2369
Schistosoma mansoni serine/threonine protein kinase 0.037 1 1
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0062 0.0839 0.0494
Giardia lamblia Kinase, CMGC CDK 0.0111 0.2293 0.2003
Entamoeba histolytica protein kinase domain containing protein 0.033 0.8791 1
Brugia malayi hypothetical protein 0.0148 0.3384 0.3135
Trypanosoma cruzi cdc2-related kinase 1 0.0111 0.2293 0.2003
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.3013 0.3013
Entamoeba histolytica protein kinase domain containing protein 0.0123 0.2645 0.2709
Entamoeba histolytica protein kinase, putative 0.0123 0.2645 0.2709
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0135 0.3013 0.2751
Trypanosoma brucei cdc2-related kinase 1 0.0111 0.2293 0.2003
Echinococcus granulosus dual specificity 0.0135 0.3013 0.2751
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0135 0.3013 0.2751
Echinococcus multilocularis cyclin dependent kinase 1 0.0111 0.2293 0.2003
Loa Loa (eye worm) hypothetical protein 0.0322 0.8548 0.8494
Loa Loa (eye worm) hypothetical protein 0.0322 0.8548 0.8494
Trichomonas vaginalis CMGC family protein kinase 0.037 1 1
Trichomonas vaginalis cyclin B, putative 0.0046 0.0363 0.0363
Entamoeba histolytica protein kinase, putative 0.0135 0.3013 0.3145
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.037 1 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0111 0.2293 0.2003
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0135 0.3013 0.0934
Schistosoma mansoni serine/threonine protein kinase 0.033 0.8791 0.8746
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.033 0.8791 0.8746
Echinococcus multilocularis dual specificity 0.0135 0.3013 0.2751
Plasmodium vivax serine/threonine kinase-1, putative 0.037 1 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0111 0.2293 0.2003
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.037 1 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0111 0.2293 0.2003
Echinococcus granulosus dual specificity protein kinase clk2 0.037 1 1
Trichomonas vaginalis cyclin A, putative 0.0046 0.0363 0.0363
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0123 0.2645 0.2369
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0123 0.2645 0.2369
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0135 0.3013 0.2751
Echinococcus multilocularis dual specificity 0.0135 0.3013 0.2751
Echinococcus granulosus cyclin dependent kinase 1 0.0111 0.2293 0.2003
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.2645 0.2645
Trichomonas vaginalis CMGC family protein kinase 0.0111 0.2293 0.2293
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0135 0.3013 0.2751
Echinococcus multilocularis dual specificity protein kinase clk2 0.037 1 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.3384 0.3135
Trichomonas vaginalis cyclin B, putative 0.0046 0.0363 0.0363
Echinococcus multilocularis dual specificity 0.0135 0.3013 0.2751
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.037 1 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0111 0.2293 0.2003
Brugia malayi intracellular kinase 0.0123 0.2645 0.2369
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.033 0.8791 0.8746
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0111 0.2293 0.2003
Echinococcus multilocularis dual specificity 0.033 0.8791 0.8746
Echinococcus multilocularis cyclin dependent kinase 1 0.0111 0.2293 0.2003
Giardia lamblia Kinase, CMGC GSK 0.0123 0.2645 0.2369
Entamoeba histolytica protein kinase domain containing protein 0.0062 0.0839 0.0565
Echinococcus multilocularis cyclin dependent kinase 9 0.0072 0.1122 0.0788
Entamoeba histolytica protein kinase, putative 0.033 0.8791 1
Echinococcus granulosus cyclin dependent kinase 9 0.0062 0.0839 0.0494
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0123 0.2645 0.2369
Entamoeba histolytica protein kinase, putative 0.033 0.8791 1
Loa Loa (eye worm) hypothetical protein 0.0309 0.8173 0.8105
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.3013 0.3013
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.8173 0.8105
Trypanosoma cruzi cdc2-related kinase 3 0.0111 0.2293 0.2003
Schistosoma mansoni serine/threonine protein kinase 0.0135 0.3013 0.2751
Trichomonas vaginalis cyclin B, putative 0.0046 0.0363 0.0363
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0111 0.2293 0.2003
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0123 0.2645 0.2369
Trypanosoma brucei cdc2-related kinase 3 0.0111 0.2293 0.2003
Plasmodium vivax glycogen synthase kinase 3, putative 0.0123 0.2645 0.0457
Loa Loa (eye worm) hypothetical protein 0.0148 0.3384 0.3135
Echinococcus multilocularis cyclin dependent kinase 0.0111 0.2293 0.2003
Brugia malayi cell division control protein 2 homolog 0.0111 0.2293 0.2003
Loa Loa (eye worm) hypothetical protein 0.0103 0.205 0.1751
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.3013 0.3013
Plasmodium falciparum protein serine/threonine kinase-1 0.037 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.3013 0.3013
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.8173 0.8105
Echinococcus granulosus cyclin dependent kinase 0.0111 0.2293 0.2003
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0839 0.0494
Trichomonas vaginalis cyclin B, putative 0.0046 0.0363 0.0363
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.3013 0.3013
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.033 0.8791 0.8746
Leishmania major protein kinase, putative 0.037 1 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0121 0.2576 0.2626
Trichomonas vaginalis CMGC family protein kinase 0.0123 0.2645 0.2645
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.033 0.8791 0.8746
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.2293 0.2003
Onchocerca volvulus 0.0123 0.2645 1
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0123 0.2645 0.0457
Giardia lamblia Kinase, CMGC CLK 0.037 1 1
Plasmodium falciparum glycogen synthase kinase 3 0.0123 0.2645 0.0457
Entamoeba histolytica hypothetical protein 0.033 0.8791 1
Loa Loa (eye worm) CMGC/CLK protein kinase 0.037 1 1
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.037 1 1
Brugia malayi cyclin-dependent kinase 9 0.0062 0.0839 0.0494
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0111 0.2293 0.2003
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.033 0.8791 0.8746
Entamoeba histolytica protein kinase domain containing protein 0.0135 0.3013 0.3145
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.8173 0.8105
Trichomonas vaginalis cyclins, putative 0.0046 0.0363 0.0363
Entamoeba histolytica cell division protein kinase 2, putative 0.0111 0.2293 0.2291
Echinococcus granulosus hypothetical protein 0.0362 0.9757 0.9748
Brugia malayi Protein kinase domain containing protein 0.0111 0.2293 0.2003
Trichomonas vaginalis cyclins, putative 0.0046 0.0363 0.0363
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.037 1 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.037 1 1
Giardia lamblia Kinase, CMGC GSK 0.0123 0.2645 0.2369
Echinococcus multilocularis 0.0362 0.9757 0.9748
Echinococcus granulosus cyclin dependent kinase 9 0.0072 0.1122 0.0788
Trypanosoma cruzi cdc2-related kinase 1 0.0111 0.2293 0.2003
Echinococcus granulosus dual specificity 0.0135 0.3013 0.2751
Echinococcus granulosus dual specificity 0.0135 0.3013 0.2751
Schistosoma mansoni kinase 0.0062 0.0839 0.0494
Brugia malayi Protein kinase domain containing protein 0.033 0.8791 0.8746
Loa Loa (eye worm) hypothetical protein 0.0312 0.8261 0.8196
Trypanosoma brucei protein kinase, putative 0.0123 0.2645 0.2369
Trichomonas vaginalis CMGC family protein kinase 0.0135 0.3013 0.3013
Schistosoma mansoni serine/threonine protein kinase 0.0111 0.2293 0.2003
Echinococcus multilocularis protein kinase shaggy 0.0123 0.2645 0.2369

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.075 uM Inhibition of DYRK1A (unknown origin) assessed as inhibition of phosphate incorporation into substrate in presence of radiolabeled ATP ChEMBL. 24798019
IC50 (binding) = 0.09 uM Inhibition of rat DYRK1A assessed as inhibition of phosphate incorporation using GRSRSRSRSRSR and [gamma-33P]ATP as substrate after 30 mins by scintillation counting analysis ChEMBL. 24798019
IC50 (binding) = 0.17 uM Inhibition of CLK1 (unknown origin) assessed as inhibition of phosphate incorporation into substrate in presence of radiolabeled ATP ChEMBL. 24798019
IC50 (binding) = 0.21 uM Inhibition of mouse recombinant GST-fused CLK1 expressed in Escherichia coli cells assessed as inhibition of phosphate incorporation using GRSRSRSRSRSR and [gamma-33P]ATP as substrate after 30 mins by scintillation counting analysis ChEMBL. 24798019
IC50 (binding) = 0.22 uM Inhibition of CLK4 (unknown origin) ChEMBL. 24798019
IC50 (binding) = 0.35 uM Inhibition of DYRK1B (unknown origin) ChEMBL. 24798019
IC50 (binding) = 0.68 uM Inhibition of CLK2 (unknown origin) ChEMBL. 24798019
IC50 (binding) = 0.82 uM Inhibition of CDK9/cyclin T (unknown origin) ChEMBL. 24798019
IC50 (binding) = 1.2 uM Inhibition of DYRK3 (unknown origin) ChEMBL. 24798019
IC50 (binding) = 1.7 uM Inhibition of DYRK2 (unknown origin) ChEMBL. 24798019
IC50 (binding) = 2 uM Inhibition of GSK3 (unknown origin) assessed as inhibition of phosphate incorporation into substrate in presence of radiolabeled ATP ChEMBL. 24798019
IC50 (binding) = 2.3 uM Inhibition of CLK3 (unknown origin) ChEMBL. 24798019
IC50 (binding) = 5.3 uM Inhibition of CDK1 (unknown origin) assessed as inhibition of phosphate incorporation into substrate in presence of radiolabeled ATP ChEMBL. 24798019
IC50 (binding) = 8.2 uM Inhibition of CDK2/cyclin A (unknown origin) ChEMBL. 24798019
IC50 (binding) = 9 uM Inhibition of CDK5 (unknown origin) assessed as inhibition of phosphate incorporation into substrate in presence of radiolabeled ATP ChEMBL. 24798019
IC50 (binding) > 10 uM Inhibition of CDK5/p25 (unknown origin) assessed as inhibition of phosphate incorporation using histone 1 and [gamma-33P]ATP as substrate after 30 mins by scintillation counting analysis ChEMBL. 24798019

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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