Detailed information for compound 1909258

Basic information

Technical information
  • TDR Targets ID: 1909258
  • Name: ethyl 3-[(3-amino-6-methoxythieno[5,4-b]quino line-2-carbonyl)amino]benzoate
  • MW: 421.469 | Formula: C22H19N3O4S
  • H donors: 2 H acceptors: 3 LogP: 4.77 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cccc(c1)NC(=O)c1sc2c(c1N)cc1c(n2)ccc(c1)OC
  • InChi: 1S/C22H19N3O4S/c1-3-29-22(27)12-5-4-6-14(9-12)24-20(26)19-18(23)16-11-13-10-15(28-2)7-8-17(13)25-21(16)30-19/h4-11H,3,23H2,1-2H3,(H,24,26)
  • InChiKey: HLIPYNIISWFYGG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 3-[(3-amino-6-methoxy-thieno[5,4-b]quinoline-2-carbonyl)amino]benzoate
  • 3-[[(3-amino-6-methoxy-2-thieno[5,4-b]quinolinyl)-oxomethyl]amino]benzoic acid ethyl ester
  • 3-[(3-amino-6-methoxy-thieno[5,4-b]quinoline-2-carbonyl)amino]benzoic acid ethyl ester
  • ethyl 3-[(3-amino-6-methoxy-thieno[5,4-b]quinolin-2-yl)carbonylamino]benzoate
  • AG-690/40698789
  • Oprea1_541044
  • BAS 02254774
  • ZINC00862124
  • Oprea1_772870

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0024 0.0639 0.0639
Echinococcus multilocularis ecdysone induced protein 78C 0.0005 0.007 0.007
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0019 0.0502 0.2637
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0005 0.007 0.0152
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0019 0.0502 0.0502
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0044 0.1275 0.8924
Schistosoma mansoni cpg binding protein 0.0014 0.0341 0.0341
Loa Loa (eye worm) aldehyde dehydrogenase 0.0003 0.0023 0.003
Schistosoma mansoni steroid hormone receptor ad4bp 0.0005 0.007 0.007
Echinococcus granulosus histone lysine methyltransferase setb 0.0016 0.0399 0.0399
Echinococcus multilocularis thyroid hormone receptor alpha 0.0005 0.007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0005 0.007 0.0091
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0003 0.0023 0.003
Brugia malayi Steroid receptor seven-up type 2 0.0005 0.007 0.0091
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0024 0.0639 0.0639
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.0304 0.9181 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0005 0.007 0.0091
Loa Loa (eye worm) hypothetical protein 0.0043 0.1235 0.1605
Echinococcus granulosus para nitrobenzyl esterase 0.0043 0.1235 0.1235
Onchocerca volvulus 0.0043 0.1235 0.336
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0003 0.0023 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0005 0.007 0.0091
Echinococcus granulosus segment polarity protein dishevelled 0.0004 0.0052 0.0052
Echinococcus multilocularis neuroligin 0.0043 0.1235 0.1235
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0003 0.0017 0.0007
Schistosoma mansoni hypothetical protein 0.0196 0.5895 0.5895
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0005 0.007 0.007
Loa Loa (eye worm) acetylcholinesterase 1 0.0255 0.7692 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0019 0.0502 0.0502
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1761 0.1761
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0007 0.0128 0.0612
Echinococcus multilocularis para nitrobenzyl esterase 0.0043 0.1235 0.1235
Loa Loa (eye worm) hypothetical protein 0.0043 0.1235 0.1605
Brugia malayi Pre-SET motif family protein 0.0107 0.3195 0.4154
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0107 0.3195 0.4154
Brugia malayi ecdysteroid receptor 0.0005 0.007 0.0091
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0003 0.001 0.001
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0003 0.0023 0.0023
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0019 0.0502 0.2637
Schistosoma mansoni dishevelled 0.0004 0.0052 0.0052
Echinococcus granulosus ubiquitin specific protease 41 0.0019 0.0502 0.0502
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0007 0.0128 0.0567
Loa Loa (eye worm) RasGEF domain-containing protein 0.0003 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0003 0.0015 0.0019
Echinococcus multilocularis regulator of G protein signaling 7 0.0004 0.0052 0.0052
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0004 0.0052 0.0067
Loa Loa (eye worm) hypothetical protein 0.0005 0.007 0.0091
Loa Loa (eye worm) hypothetical protein 0.0005 0.007 0.0091
Plasmodium falciparum phenylalanine--tRNA ligase 0.0018 0.0484 0.2055
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0017 0.0007
Echinococcus granulosus thioredoxin glutathione reductase 0.002 0.0523 0.0523
Echinococcus granulosus acetylcholinesterase 0.0255 0.7692 0.7692
Loa Loa (eye worm) hypothetical protein 0.0016 0.0399 0.0519
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0005 0.007 0.0091
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0044 0.1275 0.1367
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0003 0.0017 0.0007
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0003 0.0015 0.0015
Schistosoma mansoni aldehyde dehydrogenase 0.0003 0.0023 0.0023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0829 0.0829
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0049 0.1426 0.1532
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0044 0.1275 0.1367
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0003 0.0023 0.0023
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0024 0.0639 0.0831
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0255 0.7692 0.7692
Loa Loa (eye worm) hypothetical protein 0.0255 0.7692 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0004 0.0043 0.0043
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0019 0.0502 0.0502
Echinococcus multilocularis cpg binding protein 0.0015 0.0365 0.0365
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0018 0.0484 0.2505
Brugia malayi RasGEF domain containing protein 0.0003 0.0015 0.0019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0024 0.0639 0.0831
Onchocerca volvulus 0.0043 0.1235 0.336
Brugia malayi Carboxylesterase family protein 0.0043 0.1235 0.1605
Schistosoma mansoni aldehyde dehydrogenase 0.0003 0.0023 0.0023
Loa Loa (eye worm) carboxylesterase 0.0043 0.1235 0.1605
Brugia malayi N-terminal motif family protein 0.0003 0.0015 0.0019
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0515 0.2709
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0003 0.0023 0.0023
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0005 0.007 0.0091
Brugia malayi hypothetical protein 0.0004 0.0052 0.0067
Loa Loa (eye worm) hypothetical protein 0.0019 0.0502 0.0653
Brugia malayi hypothetical protein 0.0043 0.1235 0.1605
Trichomonas vaginalis set domain proteins, putative 0.0122 0.3646 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0004 0.0043 0.0043
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0005 0.007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0005 0.007 0.0091
Brugia malayi nuclear hormone receptor 0.0005 0.007 0.0091
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1761 0.1898
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0017 0.0007
Loa Loa (eye worm) carboxylesterase 0.0043 0.1235 0.1605
Echinococcus granulosus regulator of G protein signaling 7 0.0004 0.0052 0.0052
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0003 0.0023 0.0047
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0007 0.0128 0.0567
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0005 0.0073 0.0095
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0003 0.0023 0.0023
Trypanosoma cruzi trypanothione reductase, putative 0.0007 0.0128 0.0612
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0005 0.0073 0.0095
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1761 0.1761
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0017 0.0007
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0007 0.0128 0.0567
Loa Loa (eye worm) RasGEF domain-containing protein 0.0003 0.0015 0.0019
Loa Loa (eye worm) carboxylesterase 0.0255 0.7692 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0399 0.0399
Schistosoma mansoni ras GTP exchange factor 0.0003 0.0015 0.0015
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0004 0.0052 0.0052
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0.0069 0.0069
Trichomonas vaginalis spcc417.12 protein, putative 0.0043 0.1235 0.336
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0064 0.1863 1
Schistosoma mansoni acetylcholinesterase 0.0043 0.1235 0.1235
Loa Loa (eye worm) hypothetical protein 0.0005 0.007 0.0091
Echinococcus multilocularis dnaJ subfamily B 0.0196 0.5895 0.5895
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.007 0.007
Toxoplasma gondii hypothetical protein 0.0004 0.0052 0.0155
Echinococcus multilocularis regulator of G protein signaling 7 0.0004 0.0052 0.0052
Echinococcus multilocularis son of sevenless 1 0.0003 0.0015 0.0015
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0003 0.0023 0.0023
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0003 0.0023 0.0047
Echinococcus granulosus acetylcholinesterase 0.0255 0.7692 0.7692
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0019 0.0502 0.1342
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0017 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0003 0.0017 0.0007
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0004 0.0052 0.0103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0003 0.0017 0.0007
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0007 0.0128 0.0612
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0005 0.007 0.007
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0044 0.1275 0.1367
Echinococcus multilocularis segment polarity protein dishevelled 0.0004 0.0052 0.0052
Onchocerca volvulus 0.0043 0.1235 0.336
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0019 0.0502 0.1342
Toxoplasma gondii histone lysine methyltransferase SET1 0.0027 0.0734 0.3862
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1761 0.9444
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0007 0.0128 0.0567
Schistosoma mansoni BC026374 protein (S09 family) 0.0043 0.1235 0.1235
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0064 0.1863 0.5091
Onchocerca volvulus Bile acid receptor homolog 0.0005 0.007 0.0152
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0007 0.0128 0.0166
Echinococcus multilocularis segment polarity protein dishevelled 0.0004 0.0052 0.0052
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0019 0.0515 0.0537
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0043 0.1235 0.1323
Echinococcus granulosus Pleckstrin G protein interacting region 0.0004 0.0052 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0007 0.0128 0.0612
Echinococcus multilocularis FTZ F1 alpha 0.0005 0.007 0.007
Echinococcus granulosus Protein son of sevenless 0.0003 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0005 0.007 0.0091
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0003 0.0023 0.0023
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0087 0.2558 0.7005
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0064 0.1863 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0003 0.0017 0.0007
Onchocerca volvulus 0.0043 0.1235 0.336
Echinococcus granulosus BC026374 protein S09 family 0.0043 0.1235 0.1235
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0003 0.0023 0.003
Loa Loa (eye worm) hypothetical protein 0.0255 0.7692 1
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0003 0.0023 0.003
Echinococcus multilocularis thioredoxin glutathione reductase 0.002 0.0523 0.0523
Leishmania major trypanothione reductase 0.0019 0.0515 0.2674
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0064 0.1863 1
Brugia malayi Pre-SET motif family protein 0.0016 0.0399 0.0519
Mycobacterium tuberculosis Carboxylesterase LipT 0.0043 0.1235 0.1323
Giardia lamblia NADH oxidase lateral transfer candidate 0.0007 0.0128 0.0567
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0007 0.0128 0.0567
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0007 0.0128 0.0612
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0003 0.0023 0.0047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0005 0.007 0.0091
Echinococcus granulosus cpg binding protein 0.0015 0.0365 0.0365
Trichomonas vaginalis helicase, putative 0.0003 0.0017 0.0007
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0003 0.0023 0.0047
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0019 0.0502 0.2602
Brugia malayi F/Y-rich N-terminus family protein 0.0005 0.0067 0.0088
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0007 0.0128 0.0114
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0005 0.007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0005 0.007 0.0091
Plasmodium falciparum thioredoxin reductase 0.0019 0.0515 0.2234
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0045 0.1301 0.9107
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0005 0.007 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0005 0.007 0.0091
Loa Loa (eye worm) thioredoxin reductase 0.0019 0.0515 0.067
Loa Loa (eye worm) hypothetical protein 0.0004 0.0052 0.0067
Loa Loa (eye worm) hypothetical protein 0.0005 0.007 0.0091
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0018 0.0484 0.2055
Loa Loa (eye worm) hypothetical protein 0.0004 0.0052 0.0067
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0024 0.0639 0.0639
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0019 0.0502 0.2602
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0018 0.0484 0.063
Brugia malayi Thioredoxin reductase 0.0019 0.0515 0.067
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0018 0.0484 0.2055
Onchocerca volvulus 0.0043 0.1235 0.336
Onchocerca volvulus 0.0122 0.3646 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0049 0.1426 1
Schistosoma mansoni microtubule-associated protein tau 0.0331 1 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0019 0.0502 0.0653
Loa Loa (eye worm) hypothetical protein 0.0003 0.0015 0.0019
Brugia malayi photoreceptor-specific nuclear receptor 0.0005 0.007 0.0091
Schistosoma mansoni RAR-like nuclear receptor 0.0005 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0017 0.0007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0007 0.0128 0.0612
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0064 0.1863 1
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.0304 0.9181 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0043 0.1235 0.1323
Treponema pallidum NADH oxidase 0.0007 0.0128 0.0567
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1761 0.1898
Schistosoma mansoni dishevelled 0.0004 0.0052 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0007 0.0128 0.0612
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0007 0.0128 0.0128
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0003 0.0023 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.007 0.007
Mycobacterium tuberculosis Probable oxidoreductase 0.0049 0.1426 0.1532
Schistosoma mansoni retinoic acid receptor RXR 0.0005 0.007 0.007
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0064 0.1863 0.1863
Echinococcus granulosus regulator of G protein signaling 7 0.0004 0.0052 0.0052
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0003 0.0023 0.0023
Onchocerca volvulus 0.0014 0.0341 0.09
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0007 0.0128 0.0567
Schistosoma mansoni aldehyde dehydrogenase 0.0003 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0005 0.007 0.0091
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0003 0.0023 0.0047
Loa Loa (eye worm) hypothetical protein 0.0043 0.1235 0.1605
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0005 0.007 0.0091
Brugia malayi regulator of G-protein signaling egl-10 0.0004 0.0052 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0024 0.0639 0.0639
Loa Loa (eye worm) hypothetical protein 0.0004 0.0052 0.0067
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0064 0.1863 1
Schistosoma mansoni nuclear hormone receptor 0.0005 0.007 0.007
Loa Loa (eye worm) glutathione reductase 0.0019 0.0515 0.067
Toxoplasma gondii thioredoxin reductase 0.0019 0.0515 0.2674
Echinococcus granulosus FTZ F1 alpha 0.0005 0.007 0.007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1761 0.1898
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0024 0.0639 0.0639
Loa Loa (eye worm) hypothetical protein 0.0005 0.007 0.0091
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0049 0.1426 0.1532
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0003 0.0015 0.0015
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0003 0.0023 0.0047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0007 0.0128 0.0612
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0005 0.007 0.007
Echinococcus granulosus dnaJ subfamily B 0.0196 0.5895 0.5895
Loa Loa (eye worm) hypothetical protein 0.0043 0.1235 0.1605
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0005 0.007 0.007
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0003 0.0023 0.0047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0007 0.0128 0.0612
Loa Loa (eye worm) hypothetical protein 0.0064 0.1863 0.2423
Echinococcus granulosus ecdysone induced protein 78C 0.0005 0.007 0.007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0005 0.007 0.007
Brugia malayi CXXC zinc finger family protein 0.0014 0.0341 0.0444
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0004 0.0052 0.0067
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0004 0.0052 0.0052
Echinococcus multilocularis acetylcholinesterase 0.0255 0.7692 0.7692
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0018 0.0484 0.1293
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0003 0.0023 0.0023
Onchocerca volvulus 0.0004 0.0052 0.0103
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0064 0.1863 1
Echinococcus multilocularis Protein son of sevenless 0.0003 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0017 0.0007
Schistosoma mansoni cpg binding protein 0.0015 0.0365 0.0365
Schistosoma mansoni cpg binding protein 0.0015 0.0365 0.0365
Brugia malayi DIX domain containing protein 0.0004 0.0052 0.0067
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0007 0.0128 0.0114
Loa Loa (eye worm) hypothetical protein 0.0003 0.0023 0.003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0005 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0502 0.1342
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0003 0.0023 0.0047
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0018 0.0484 0.1293
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0004 0.0043 0.0043
Brugia malayi Carboxylesterase family protein 0.0043 0.1235 0.1605
Echinococcus granulosus neuroligin 0.0043 0.1235 0.1235
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0017 0.0007
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0003 0.0015 0.0015
Onchocerca volvulus 0.0005 0.007 0.0152
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0016 0.0399 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0005 0.007 0.0091
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.007 0.0091
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0.0069 0.0069
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0003 0.0023 0.0023
Brugia malayi RasGEF domain containing protein 0.0003 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0005 0.007 0.0091
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0003 0.0023 0.0023
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0016 0.0399 0.2044
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0018 0.0484 0.0484
Brugia malayi Carboxylesterase family protein 0.0255 0.7692 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0007 0.0128 0.0567
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0017 0.0007
Brugia malayi hypothetical protein 0.0004 0.0052 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0005 0.007 0.0091
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0019 0.0502 0.2602
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0005 0.007 0.007
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0003 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0005 0.007 0.0091
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0003 0.0015 0.0015
Loa Loa (eye worm) histone methyltransferase 0.0005 0.0069 0.009
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0043 0.1235 0.1235
Onchocerca volvulus Protein ultraspiracle homolog 0.0005 0.007 0.0152
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0003 0.0023 0.0023
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0005 0.007 0.007
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0019 0.0502 0.0502
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0005 0.007 0.0091
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0064 0.1863 1
Echinococcus granulosus carboxylesterase 5A 0.0255 0.7692 0.7692
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0003 0.0023 0.0047
Loa Loa (eye worm) hypothetical protein 0.0003 0.0023 0.003
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0007 0.0128 0.0114
Brugia malayi RasGEF domain containing protein 0.0003 0.0015 0.0019
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0007 0.0128 0.0114
Brugia malayi aldehyde dehydrogenase 0.0003 0.0023 0.003
Plasmodium vivax SET domain protein, putative 0.0016 0.0399 0.1566
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1761 0.1761
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0064 0.1863 0.1863
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0018 0.0484 0.0484
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0003 0.0023 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.007 0.007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0024 0.0639 0.0639
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0019 0.0502 0.0502
Schistosoma mansoni dep domain containing protein 0.0004 0.0052 0.0052
Onchocerca volvulus 0.0016 0.0399 0.106
Schistosoma mansoni neuroligin 3 (S09 family) 0.0043 0.1235 0.1235
Schistosoma mansoni regulator of G protein signaling 0.0004 0.0052 0.0052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0024 0.0639 0.0639
Schistosoma mansoni thyroid hormone receptor 0.0005 0.007 0.007
Echinococcus multilocularis ubiquitin specific protease 41 0.0019 0.0502 0.0502
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0043 0.1235 0.336
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0399 0.0399
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.007 0.007
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0003 0.0023 0.0047
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0016 0.0399 0.0399
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0043 0.1235 0.1235
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1761 0.1761
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0003 0.0015 0.0015
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0007 0.0128 0.0128
Trichomonas vaginalis glutathione reductase, putative 0.0007 0.0128 0.0311
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0018 0.0484 0.0484
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0003 0.0023 0.003
Plasmodium vivax thioredoxin reductase, putative 0.0019 0.0515 0.2234
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0016 0.0399 0.0399
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0005 0.007 0.0091
Chlamydia trachomatis phenylalanine--tRNA ligase subunit alpha 0.0304 0.9181 1
Schistosoma mansoni gliotactin 0.0043 0.1235 0.1235
Echinococcus granulosus segment polarity protein dishevelled 0.0004 0.0052 0.0052
Brugia malayi glutathione reductase 0.0019 0.0515 0.067
Brugia malayi nuclear receptor NHR-88 0.0005 0.007 0.0091
Schistosoma mansoni coup transcription factor 0.0005 0.007 0.007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0007 0.0128 0.0567
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0004 0.0052 0.0067
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0005 0.007 0.007
Schistosoma mansoni aldehyde dehydrogenase 0.0003 0.0023 0.0023
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0007 0.0128 0.0128
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0003 0.0023 0.0047
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0043 0.1235 0.1235
Schistosoma mansoni aldehyde dehydrogenase 0.0003 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0043 0.1235 0.1605
Loa Loa (eye worm) CXXC zinc finger family protein 0.0014 0.0341 0.0444
Loa Loa (eye worm) RasGEF domain-containing protein 0.0003 0.0015 0.0019
Mycobacterium tuberculosis Probable dehydrogenase 0.0044 0.1275 0.1367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0005 0.007 0.0091
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0007 0.0128 0.0114
Schistosoma mansoni thyroid hormone receptor 0.0005 0.007 0.007
Mycobacterium ulcerans carboxylesterase, LipT 0.0043 0.1235 0.1323
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0043 0.1235 0.1235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0005 0.007 0.0091
Echinococcus multilocularis carboxylesterase 5A 0.0255 0.7692 0.7692
Echinococcus granulosus mixed lineage leukemia protein mll 0.0004 0.0043 0.0043
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0003 0.0023 0.0024
Brugia malayi N-terminal motif family protein 0.0087 0.2558 0.3326
Echinococcus multilocularis BC026374 protein (S09 family) 0.0043 0.1235 0.1235
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0005 0.007 0.007
Brugia malayi Carboxylesterase family protein 0.0043 0.1235 0.1605
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0043 0.0043
Brugia malayi steroid hormone receptor 0.0005 0.007 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0017 0.0007
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0064 0.1863 0.1863
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0003 0.0023 0.0047
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0003 0.0023 0.0024
Brugia malayi N-terminal motif family protein 0.0003 0.0015 0.0019
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0003 0.0015 0.0015
Toxoplasma gondii NADPH-glutathione reductase 0.0007 0.0128 0.0567
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0064 0.1863 0.2423
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0018 0.0484 0.0484
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0003 0.0017 0.0007
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0064 0.1863 1
Plasmodium vivax glutathione reductase, putative 0.0019 0.0515 0.2234
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0015 0.0373 0.0373
Echinococcus multilocularis microtubule associated protein 2 0.0331 1 1
Schistosoma mansoni z-protein (S1r protein) 0.0004 0.0052 0.0052
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0005 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0005 0.007 0.0091
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0003 0.0017 0.0007
Trypanosoma brucei trypanothione reductase 0.0019 0.0515 0.2674
Brugia malayi Aldehyde dehydrogenase protein 4 0.0003 0.0023 0.003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0005 0.007 0.007
Echinococcus multilocularis acetylcholinesterase 0.0255 0.7692 0.7692
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0304 0.9181 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0016 0.0399 0.0399
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1761 0.9444
Plasmodium falciparum glutathione reductase 0.0019 0.0515 0.2234
Loa Loa (eye worm) DIX domain-containing protein 0.0004 0.0052 0.0067
Loa Loa (eye worm) hypothetical protein 0.0043 0.1235 0.1605
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0003 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0005 0.007 0.0091
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1761 0.1898
Plasmodium falciparum phenylalanine--tRNA ligase 0.0018 0.0484 0.2055
Brugia malayi Carboxylesterase family protein 0.0255 0.7692 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.2558 0.3326
Trichomonas vaginalis mercuric reductase, putative 0.0007 0.0128 0.0311
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0044 0.1275 0.1367
Echinococcus granulosus ras GTP exchange factor 0.0003 0.0015 0.0015
Brugia malayi Carboxylesterase family protein 0.0043 0.1235 0.1605
Mycobacterium tuberculosis Probable reductase 0.0044 0.1275 0.1367
Echinococcus multilocularis ras GTP exchange factor 0.0003 0.0015 0.0015
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0043 0.1235 0.1235
Loa Loa (eye worm) hypothetical protein 0.0043 0.1235 0.1605
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0019 0.0502 0.0502
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0018 0.0484 0.063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0003 0.0017 0.0007
Echinococcus granulosus son of sevenless 1 0.0003 0.0015 0.0015
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0003 0.0023 0.0023
Loa Loa (eye worm) steroid hormone receptor 0.0005 0.007 0.0091
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0003 0.0023 0.0047
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0007 0.0128 0.0114
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0064 0.1863 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0019 0.0502 0.2637
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0007 0.0128 0.0567

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 29.6 % Inhibition of recombinant PKCepsilon (unknown origin)-MBP-tagged RACK2 interaction after 1 hr by ELISA-based assay relative to untreated control ChEMBL. 24712764

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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