Detailed information for compound 1985582

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 221.271 | Formula: C13H16FNO
  • H donors: 1 H acceptors: 1 LogP: 3.6 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC/C(=N\O)/C(=C/c1ccc(c(c1)C)F)/C
  • InChi: 1S/C13H16FNO/c1-4-13(15-16)10(3)8-11-5-6-12(14)9(2)7-11/h5-8,16H,4H2,1-3H3/b10-8+,15-13+
  • InChiKey: WRHHATMLNUQQTB-MZRBSKCNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni wnt related 0.0013 0.009 0.0179
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0088 0.1231 0.1231
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0153 0.2874
Loa Loa (eye worm) CXXC zinc finger family protein 0.0024 0.0256 0.06
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0153 0.0153
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0094 0.0222
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Loa Loa (eye worm) hypothetical protein 0.0041 0.0523 0.1226
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Giardia lamblia Sugar-proton symporter 0.0017 0.0153 0.346
Onchocerca volvulus 0.0024 0.0256 0.0661
Loa Loa (eye worm) hypothetical protein 0.0081 0.1124 0.2637
Trypanosoma brucei PAB1-binding protein , putative 0.0021 0.0212 0.3984
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0453 0.0453
Schistosoma mansoni alpha glucosidase 0.0042 0.0525 0.1052
Echinococcus granulosus dnaJ subfamily B 0.0338 0.4994 1
Trypanosoma brucei transcription factor BTF3, putative 0.0029 0.0334 0.6269
Brugia malayi Zinc finger, C2H2 type family protein 0.029 0.4265 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0523 0.1344
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0454 0.0597
Echinococcus multilocularis solute carrier family 22 0.0017 0.0153 0.0153
Entamoeba histolytica hypothetical protein 0.0029 0.0334 0.2966
Trichomonas vaginalis esterase, putative 0.0041 0.0523 0.1678
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0153 0.0153
Trypanosoma cruzi transcription factor btf3, putative 0.0029 0.0334 0.6269
Echinococcus multilocularis wingless type MMTV integration site family 0.0013 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Trichomonas vaginalis sugar transporter, putative 0.0037 0.046 0.1478
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0094 0.0222
Onchocerca volvulus 0.0017 0.0153 0.0114
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0523 0.1344
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0523 0.1226
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Trypanosoma brucei sugar transporter, putative 0.0017 0.0153 0.2874
Schistosoma mansoni alpha-glucosidase 0.0161 0.2331 0.4668
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0369 0.0949
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0017 0.0153 0.2926
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0132 0.2473
Onchocerca volvulus 0.0041 0.0523 0.2083
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Trichomonas vaginalis glucosylceramidase, putative 0.014 0.2009 0.6449
Plasmodium falciparum hexose transporter 0.012 0.1711 0.2253
Leishmania major hypothetical protein, conserved 0.0021 0.0212 0.3984
Onchocerca volvulus 0.0017 0.0153 0.0114
Schistosoma mansoni wnt-5 0.0013 0.009 0.0179
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0088 0.1231 0.2465
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0369 0.0865
Chlamydia trachomatis proline--tRNA ligase 0.0013 0.009 0.2978
Toxoplasma gondii ABC1 family protein 0.0041 0.0523 0.1041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0088 0.1231 0.2465
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Loa Loa (eye worm) Wnt2 protein 0.0013 0.009 0.021
Brugia malayi CHE-14 protein 0.0035 0.0424 0.0995
Mycobacterium ulcerans lipase LipD 0.0041 0.0523 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.1711 0.3427
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0454 0.0597
Brugia malayi wnt family protein 0.0013 0.009 0.021
Plasmodium falciparum protein kinase 7 0.034 0.5021 0.6612
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0088 0.1231 0.2886
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0369 0.0739
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0212 0.0279
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.3115 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0303 0.0303
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0453 0.0908
Brugia malayi wnt family protein 0.0013 0.009 0.021
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0442 0.1036
Brugia malayi wnt family protein 0.0013 0.009 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.046 0.1478
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0017 0.0153 0.2926
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0453 0.0453
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0153 1
Entamoeba histolytica hypothetical protein 0.0027 0.0303 0.2692
Mycobacterium tuberculosis Conserved protein 0.0041 0.0523 0.1344
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0523 0.1678
Trichomonas vaginalis myo-inositol transporter, putative 0.0017 0.0153 0.0491
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Loa Loa (eye worm) hypothetical protein 0.0021 0.0212 0.0497
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0442 0.1036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0442 0.0442
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0369 0.6933
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Loa Loa (eye worm) hypothetical protein 0.0041 0.0523 0.1226
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0454 0.0903
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0265 0.3889 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0346 0.0346
Trypanosoma cruzi hexose transporter, putative 0.0037 0.046 0.8651
Plasmodium falciparum protein kinase 6 0.051 0.7594 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0132 0.0422
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0017 0.0153 0.0201
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0453 0.0908
Plasmodium falciparum mitogen-activated protein kinase 2 0.0194 0.2828 0.3724
Loa Loa (eye worm) transcription factor SMAD2 0.0099 0.1385 0.3248
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0453 0.0908
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0153 0.0491
Echinococcus multilocularis protein dispatched 1 0.004 0.0499 0.0499
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.1711 0.3427
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0523 0.9822
Trypanosoma brucei glucose transporter, putative 0.0037 0.046 0.8651
Onchocerca volvulus 0.0017 0.0153 0.0114
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0523 0.1678
Leishmania major glucose transporter/membrane transporter D2, putative 0.0037 0.046 0.8651
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0453 0.0453
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0303 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0523 0.1678
Echinococcus multilocularis solute carrier family 22 0.0017 0.0153 0.0153
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0369 0.6933
Leishmania major glucose transporter, lmgt1 0.0037 0.046 0.8651
Leishmania major hypothetical protein, conserved 0.0041 0.0523 0.9822
Echinococcus granulosus solute carrier family 22 0.0017 0.0153 0.0306
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0454 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0153 0.0491
Trichomonas vaginalis sugar transport protein, putative 0.0017 0.0153 0.0491
Trichomonas vaginalis glucose transporter, putative 0.0017 0.0153 0.0491
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0454 0.0597
Trypanosoma brucei glucosidase, putative 0.0042 0.0525 0.9871
Toxoplasma gondii histone lysine methyltransferase SET1 0.0045 0.0576 0.1147
Schistosoma mansoni protein kinase 0.0037 0.0453 0.0908
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.034 0.0797
Schistosoma mansoni sugar transporter 0.0017 0.0153 0.0306
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0017 0.0153 0.0393
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0035 0.0424 0.0995
Plasmodium falciparum proline--tRNA ligase 0.0042 0.0532 0.0701
Echinococcus multilocularis GPCR, family 2 0.0013 0.0094 0.0094
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0013 0.009 0.1725
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0153 0.0359
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.1711 0.1711
Echinococcus multilocularis solute carrier family 22 0.0017 0.0153 0.0153
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0523 0.1226
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.3115 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0525 0.1686
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0453 0.0453
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0523 0.9822
Onchocerca volvulus 0.0017 0.0153 0.0114
Entamoeba histolytica hypothetical protein 0.003 0.0346 0.3079
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0303 0.5689
Treponema pallidum prolyl-tRNA synthetase 0.0013 0.009 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0213 0.3115 0.7305
Echinococcus granulosus General substrate transporter 0.0103 0.1456 0.2916
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Schistosoma mansoni cpg binding protein 0.0025 0.0276 0.0553
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Loa Loa (eye worm) hypothetical protein 0.0037 0.0453 0.1063
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0303 0.0972
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Echinococcus granulosus transcription factor btf3 0.0029 0.0334 0.0668
Trichomonas vaginalis glucosylceramidase, putative 0.014 0.2009 0.6449
Echinococcus multilocularis General substrate transporter 0.0103 0.1456 0.1456
Echinococcus granulosus zinc finger transcription factor gli2 0.029 0.4265 0.854
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.3115 1
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0242 0.4625
Entamoeba histolytica protein kinase, putative 0.0037 0.0453 0.403
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0369 0.6933
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0153 0.0359
Schistosoma mansoni alpha-glucosidase 0.0161 0.2331 0.4668
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0369 0.0369
Trypanosoma brucei glucose transporter, putative 0.0037 0.046 0.8651
Brugia malayi major facilitator superfamily protein 0.0017 0.0153 0.0359
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0132 0.0422
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.3115 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0009 0.0017
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0212 0.3984
Echinococcus granulosus Protein patched homolog 1 0.0035 0.0424 0.085
Onchocerca volvulus 0.0017 0.0153 0.0114
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0525 0.1686
Onchocerca volvulus Putative transporter 0.0017 0.0153 0.0114
Onchocerca volvulus 0.0017 0.0153 0.0114
Schistosoma mansoni hypothetical protein 0.0013 0.0094 0.0189
Onchocerca volvulus 0.0017 0.0153 0.0114
Leishmania major hypothetical protein, conserved 0.0017 0.0153 0.2874
Trypanosoma brucei glucose transporter, putative 0.0037 0.046 0.8651
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0132 0.0422
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0346 0.0693
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0454 0.0903
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0242 0.0622
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0094 0.0222
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0088 0.1231 0.2465
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0525 0.0525
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.0094 0.0094
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0532 1
Schistosoma mansoni hypothetical protein 0.0034 0.0405 0.0812
Echinococcus granulosus protein Wnt 1 0.0013 0.009 0.0179
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0525 0.4671
Schistosoma mansoni hypothetical protein 0.003 0.0346 0.0693
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0453 0.1063
Onchocerca volvulus 0.0017 0.0153 0.0114
Mycobacterium ulcerans sugar transporter 0.0017 0.0153 0.2926
Onchocerca volvulus 0.0017 0.0153 0.0114
Schistosoma mansoni cpg binding protein 0.0024 0.0256 0.0512
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0523 0.1047
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0525 0.1232
Echinococcus granulosus Protein Wnt-11b 0.0013 0.009 0.0179
Brugia malayi hypothetical protein 0.003 0.0346 0.0812
Schistosoma mansoni hypothetical protein 0.0195 0.2838 0.5683
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.3115 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0525 0.1686
Entamoeba histolytica transcription factor BTF3, putative 0.0029 0.0334 0.2966
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.1711 0.3427
Leishmania major protein kinase, putative 0.0037 0.0453 0.8517
Loa Loa (eye worm) histone methyltransferase 0.0007 0.0009 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.014 0.2009 0.6449
Loa Loa (eye worm) hypothetical protein 0.0041 0.0523 0.1226
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0523 0.1047
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0453 0.1455
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0419 0.0419
Echinococcus granulosus solute carrier family 22 0.0017 0.0153 0.0306
Echinococcus granulosus sterol regulatory element binding protein 0.0035 0.0424 0.085
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0041 0.0519 0.1217
Trichomonas vaginalis glucose transporter, putative 0.0037 0.046 0.1478
Schistosoma mansoni transcription factor btf3 0.0029 0.0334 0.0668
Entamoeba histolytica hypothetical protein 0.003 0.0346 0.3079
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Onchocerca volvulus 0.0017 0.0153 0.0114
Loa Loa (eye worm) wnt-4 protein 0.0013 0.009 0.021
Trypanosoma cruzi hexose transporter, putative 0.0037 0.046 0.8651
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0369 0.0369
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0015 0.0121 0.0284
Plasmodium falciparum basic transcription factor 3b, putative 0.0029 0.0334 0.0439
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0369 0.0735
Leishmania major myo-inositol/proton symporter (MIT) 0.0017 0.0153 0.2874
Trypanosoma brucei glucose transporter 1E 0.0037 0.046 0.8651
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.1711 0.1711
Brugia malayi hypothetical protein 0.0017 0.0153 0.0359
Toxoplasma gondii sugar transporter ST2 0.0017 0.0153 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0153 0.0491
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0369 0.0739
Loa Loa (eye worm) hypothetical protein 0.0041 0.0523 0.1226
Leishmania major glucose transporter, lmgt3 0.0037 0.046 0.8651
Schistosoma mansoni hypothetical protein 0.0013 0.0094 0.0189
Echinococcus multilocularis wnt family member wnt11 2 0.0013 0.009 0.009
Brugia malayi F/Y-rich N-terminus family protein 0.0007 0.0007 0.0017
Echinococcus granulosus expressed conserved protein 0.0076 0.105 0.2103
Loa Loa (eye worm) hypothetical protein 0.0036 0.0442 0.1036
Loa Loa (eye worm) hypothetical protein 0.0013 0.009 0.021
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0453 0.8517
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0523 0.0523
Loa Loa (eye worm) hypothetical protein 0.0041 0.0523 0.1226
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Brugia malayi Cam kinase protein 1 0.0037 0.0453 0.1063
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0532 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0334 0.1071
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Schistosoma mansoni hypothetical protein 0.0013 0.0094 0.0189
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0132 0.0309
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0153 0.0359
Loa Loa (eye worm) hypothetical protein 0.0013 0.009 0.021
Schistosoma mansoni sugar transporter 0.0017 0.0153 0.0306
Trichomonas vaginalis glucosylceramidase, putative 0.014 0.2009 0.6449
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0303 0.0399
Echinococcus multilocularis solute carrier family 22 0.0017 0.0153 0.0153
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0525 0.1686
Mycobacterium ulcerans beta-lactamase 0.0041 0.0523 1
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0523 0.1344
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0523 0.1344
Giardia lamblia Hexose transporter 0.0017 0.0153 0.346
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0303 0.5792
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0017 0.0153 0.0393
Onchocerca volvulus 0.0017 0.0153 0.0114
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0153 0.2874
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0532 1
Brugia malayi Wnt-4 protein precursor 0.0013 0.009 0.021
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.0532 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0523 0.1678
Brugia malayi hypothetical protein 0.0021 0.0212 0.0497
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0132 0.117
Brugia malayi Wnt-2 protein precursor 0.0013 0.009 0.021
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0303 0.6849
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0132 0.0422
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.0094 0.0094
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.046 0.8651
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0369 0.0486
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0453 0.0908
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0424 0.1362
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Echinococcus granulosus Protein Wnt-111 0.0013 0.009 0.0179
Trichomonas vaginalis glucosylceramidase, putative 0.014 0.2009 0.6449
Toxoplasma gondii protein kinase, putative 0.034 0.5021 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0369 0.6933
Echinococcus granulosus lysosomal alpha glucosidase 0.0187 0.2725 0.5456
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0088 0.1231 0.2886
Echinococcus multilocularis protein Wnt 1 0.0013 0.009 0.009
Schistosoma mansoni protein kinase 0.0037 0.0453 0.0908
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0194 0.2828 0.5632
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0303 0.0606
Brugia malayi beta-lactamase 0.0041 0.0523 0.1226
Echinococcus granulosus GPCR family 2 0.0013 0.0094 0.0189
Onchocerca volvulus 0.0041 0.0523 0.2083
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Mycobacterium tuberculosis Conserved protein 0.0041 0.0523 0.1344
Brugia malayi Sugar transporter family protein 0.0017 0.0153 0.0359
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.046 0.8651
Echinococcus granulosus solute carrier family 22 0.0017 0.0153 0.0306
Echinococcus multilocularis geminin 0.0195 0.2838 0.2838
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0523 0.1047
Echinococcus granulosus protein Wnt 2 0.0013 0.009 0.0179
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0454 0.0597
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0346 0.0693
Schistosoma mansoni hypothetical protein 0.0013 0.0094 0.0189
Onchocerca volvulus 0.0017 0.0153 0.0114
Plasmodium vivax proline--tRNA ligase, putative 0.0042 0.0532 0.0701
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0303 0.0399
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0523 0.0688
Schistosoma mansoni sugar transporter 0.0017 0.0153 0.0306
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0523 0.1344
Loa Loa (eye worm) hypothetical protein 0.0013 0.009 0.021
Loa Loa (eye worm) ICD-1 protein 0.0029 0.0334 0.0782
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Trichomonas vaginalis glucosylceramidase, putative 0.0148 0.2123 0.6814
Loa Loa (eye worm) beta-lactamase 0.0041 0.0523 0.1226
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0369 0.0369
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0213 0.3115 0.7305
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0153 0.0306
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0454 0.0903
Echinococcus multilocularis cpg binding protein 0.0025 0.0276 0.0276
Echinococcus multilocularis Niemann Pick C1 protein 0.0081 0.1124 0.1124
Trichomonas vaginalis glucosylceramidase, putative 0.014 0.2009 0.6449
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0253 0.0812
Toxoplasma gondii NAC domain-containing protein 0.0029 0.0334 0.0664
Plasmodium vivax basic transcription factor 3b, putative 0.0029 0.0334 0.0439
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0523 0.1344
Loa Loa (eye worm) sugar transporter 0.0017 0.0153 0.0359
Loa Loa (eye worm) sugar transporter 0.012 0.1711 0.4012
Plasmodium vivax sugar transporter, putative 0.0017 0.0153 0.0201
Loa Loa (eye worm) hypothetical protein 0.0036 0.0442 0.1036
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0042 0.0532 0.106
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0081 0.1124 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0303 0.0606
Echinococcus multilocularis protein Wnt 2 0.0013 0.009 0.009
Brugia malayi CXXC zinc finger family protein 0.0024 0.0256 0.06
Mycobacterium ulcerans integral membrane transport protein 0.0017 0.0153 0.2926
Brugia malayi hypothetical protein 0.0017 0.0153 0.0359
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0453 0.1063
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0523 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.009 0.021
Echinococcus multilocularis dnaJ subfamily B 0.0338 0.4994 0.4994
Trichomonas vaginalis sugar transporter, putative 0.0037 0.046 0.1478
Trypanosoma cruzi sugar transporter, putative 0.0017 0.0153 0.2874
Schistosoma mansoni sugar transporter 0.0017 0.0153 0.0306
Loa Loa (eye worm) zinc finger protein 0.029 0.4265 1
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0153 0.0359
Trichomonas vaginalis sugar transporter, putative 0.0037 0.046 0.1478
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0369 0.0735
Toxoplasma gondii sugar transporter ST3 0.0017 0.0153 0.0305
Brugia malayi major facilitator superfamily protein 0.0017 0.0153 0.0359
Schistosoma mansoni hypothetical protein 0.0009 0.0039 0.0078
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0525 0.9871
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0442 0.0885
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0132 0.0422
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.2725 0.2725
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0454 0.0597
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0454 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Toxoplasma gondii sugar transporter ST1 0.0017 0.0153 0.0305
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.012 0.1711 0.1711
Leishmania major basic transcription factor 3a, putative 0.0029 0.0334 0.6269
Toxoplasma gondii transporter, major facilitator family protein 0.0017 0.0153 0.0305
Loa Loa (eye worm) hypothetical protein 0.0043 0.0543 0.1273
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0525 0.1232
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.0094 0.0189
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Mycobacterium tuberculosis Conserved protein 0.0041 0.0523 0.1344
Echinococcus multilocularis WNT 0.0013 0.009 0.009
Trypanosoma brucei glucose transporter, putative 0.0037 0.046 0.8651
Schistosoma mansoni glucose transporter 0.0017 0.0153 0.0306
Schistosoma mansoni hypothetical protein 0.012 0.1711 0.3427
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0334 0.1071
Entamoeba histolytica hypothetical protein 0.003 0.0346 0.3079
Schistosoma mansoni wnt related 0.0013 0.009 0.0179
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.012 0.1711 0.1711
Trypanosoma brucei glucose transporter, putative 0.0037 0.046 0.8651
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0525 0.1686
Plasmodium vivax ataxin-2 like protein, putative 0.0021 0.0212 0.0279
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0153 0.0359
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Toxoplasma gondii LsmAD domain-containing protein 0.0021 0.0212 0.0422
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0442 0.8456
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0153 0.0491
Brugia malayi Niemann-Pick C1 protein precursor 0.0081 0.1124 0.2637
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0525 0.4671
Trypanosoma brucei glucose transporter, putative 0.0037 0.046 0.8651
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0194 0.2828 0.3724
Entamoeba histolytica hypothetical protein 0.003 0.0346 0.3079
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0523 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.2725 0.2725
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0132 0.0422
Schistosoma mansoni mixed-lineage leukemia protein mll 0.005 0.0657 0.1315
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0525 0.9871
Onchocerca volvulus 0.0017 0.0153 0.0114
Brugia malayi beta-lactamase family protein 0.0041 0.0523 0.1226
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0132 0.0422
Loa Loa (eye worm) hypothetical protein 0.0041 0.0519 0.1217
Brugia malayi MH2 domain containing protein 0.0099 0.1385 0.3248
Entamoeba histolytica protein kinase, putative 0.0037 0.0453 0.403
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0453 0.0908
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.0094 0.0189
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Echinococcus granulosus solute carrier family 22 0.0017 0.0153 0.0306
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0009 0.0039 0.0039
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0523 0.1344
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0442 0.393
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0454 0.0597
Loa Loa (eye worm) hypothetical protein 0.0013 0.009 0.021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0088 0.1231 0.2465
Schistosoma mansoni wnt related 0.0013 0.009 0.0179
Onchocerca volvulus 0.0017 0.0153 0.0114
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0088 0.1231 0.1231
Schistosoma mansoni glucose transport protein 0.012 0.1711 0.3427
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0153 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.012 0.1711 0.5493
Echinococcus multilocularis zinc finger transcription factor gli2 0.029 0.4265 0.4265
Plasmodium vivax CDK-related protein kinase 6, putative 0.051 0.7594 1
Schistosoma mansoni glucose transport protein 0.012 0.1711 0.3427
Echinococcus granulosus cpg binding protein 0.0025 0.0276 0.0553
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0454 0.0597
Onchocerca volvulus Glucosylceramidase homolog 0.014 0.2009 1
Trypanosoma brucei glucose transporter 2A 0.0037 0.046 0.8651
Schistosoma mansoni hypothetical protein 0.0034 0.0405 0.0812
Brugia malayi isocitrate dehydrogenase 0.0031 0.0369 0.0865
Trypanosoma cruzi PAB1-binding protein , putative 0.0021 0.0212 0.3984
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0523 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0303 0.0606
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0132 0.0422
Echinococcus multilocularis WNT 0.0013 0.009 0.009
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0525 0.1686
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Echinococcus multilocularis Niemann Pick C1 protein 0.0116 0.1651 0.1651
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0242 0.0622
Echinococcus multilocularis expressed conserved protein 0.0076 0.105 0.105
Loa Loa (eye worm) MH2 domain-containing protein 0.0099 0.1385 0.3248
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0303 0.5792
Schistosoma mansoni hypothetical protein 0.0195 0.2838 0.5683
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0442 1
Onchocerca volvulus 0.0017 0.0153 0.0114
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Mycobacterium ulcerans hypothetical protein 0.0041 0.0523 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0187 0.2725 0.6389
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Brugia malayi latrophilin 2 splice variant baaae 0.0028 0.0323 0.0756
Echinococcus granulosus Niemann Pick C1 protein 0.0116 0.1651 0.3306
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0187 0.2725 0.6389
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0525 0.1686
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0525 0.1052
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0525 0.1046
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0153 0.0306
Echinococcus granulosus Protein Wnt-04 0.0013 0.009 0.0179
Plasmodium falciparum ataxin-2 like protein, putative 0.0021 0.0212 0.0279
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0132 0.2473
Trypanosoma cruzi hexose transporter, putative 0.002 0.0205 0.386
Schistosoma mansoni hypothetical protein 0.0338 0.4994 1
Plasmodium vivax hexose transporter 0.012 0.1711 0.2253
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0419 0.0839
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0442 0.0885
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0369 0.0486
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0453 0.1063
Brugia malayi Sugar transporter family protein 0.012 0.1711 0.4012
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0523 0.9822
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0525 0.9871
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0303 0.5689
Schistosoma mansoni hypothetical protein 0.0028 0.0323 0.0646
Echinococcus multilocularis transcription factor btf3 0.0029 0.0334 0.0334
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0303 0.5792
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.012 0.1711 0.3427
Onchocerca volvulus 0.0017 0.0153 0.0114
Echinococcus granulosus geminin 0.0195 0.2838 0.5683
Trypanosoma cruzi hexose transporter 0.0037 0.046 0.8651
Echinococcus granulosus Niemann Pick C1 protein 0.0081 0.1124 0.2252
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0041 0.0519 0.1217
Brugia malayi Calcitonin receptor-like protein seb-1 0.0041 0.0519 0.1217
Schistosoma mansoni cpg binding protein 0.0025 0.0276 0.0553
Schistosoma mansoni hypothetical protein 0.0034 0.0405 0.0812
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Loa Loa (eye worm) hypothetical protein 0.0035 0.0424 0.0995
Toxoplasma gondii facilitative glucose transporter GT1 0.012 0.1711 0.3408
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0369 0.0865
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Trypanosoma cruzi hexose transporter, putative 0.0037 0.046 0.8651
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0009 0.0039 0.0078
Loa Loa (eye worm) CWN-2 protein 0.0013 0.009 0.021
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0132 0.2473
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0369 0.6933
Schistosoma mansoni glucose transport protein 0.012 0.1711 0.3427
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0442 0.0885
Trypanosoma brucei glucose transporter, putative 0.0037 0.046 0.8651
Trypanosoma cruzi glucose transporter, putative 0.0017 0.0153 0.2874
Trichomonas vaginalis glucosylceramidase, putative 0.0148 0.2123 0.6814
Loa Loa (eye worm) hypothetical protein 0.0041 0.0523 0.1226
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0303 0.071
Onchocerca volvulus 0.0041 0.0523 0.2083
Loa Loa (eye worm) hypothetical protein 0.0013 0.0094 0.0222
Loa Loa (eye worm) hypothetical protein 0.0028 0.0323 0.0756
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0088 0.1231 0.2465
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0525 0.1686
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0442 0.1419
Trichomonas vaginalis glucosylceramidase, putative 0.014 0.2009 0.6449
Leishmania major glucose transporter, lmgt2 0.0037 0.046 0.8651
Loa Loa (eye worm) hypothetical protein 0.0027 0.0303 0.071
Echinococcus multilocularis sterol regulatory element binding protein 0.0035 0.0424 0.0424
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0153 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0334 0.1071
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0083 0.1143 0.229
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.3115 1
Mycobacterium leprae Probable lipase LipE 0.0041 0.0523 1
Brugia malayi Sugar transporter family protein 0.0017 0.0153 0.0359
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.046 0.8651
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0132 0.2473
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0369 0.0369
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0525 0.1686
Trypanosoma brucei glucose transporter, putative 0.0037 0.046 0.8651
Brugia malayi wnt family protein 0.0013 0.009 0.021
Echinococcus granulosus Protein Wnt-5 0.0013 0.009 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.046 0.1478
Brugia malayi beta-lactamase family protein 0.0041 0.0523 0.1226
Schistosoma mansoni patched 1 0.0035 0.0424 0.085
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0303 0.5689
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0523 0.1678
Schistosoma mansoni hypothetical protein 0.0034 0.0405 0.0812
Onchocerca volvulus 0.0108 0.1533 0.7464
Trichomonas vaginalis glucose transporter, putative 0.0037 0.046 0.1478
Echinococcus multilocularis protein patched 0.0035 0.0424 0.0424
Brugia malayi beta-NAC-like protein 0.0029 0.0334 0.0782
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0303 0.0603
Brugia malayi hypothetical protein 0.0017 0.0153 0.0359
Schistosoma mansoni wnt related 0.0013 0.009 0.0179
Trypanosoma cruzi transcription factor btf3, putative 0.0029 0.0334 0.6269
Trichomonas vaginalis sugar transporter, putative 0.0017 0.0153 0.0491
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.0532 1
Schistosoma mansoni protein kinase 0.0037 0.0453 0.0908
Brugia malayi hypothetical protein 0.0013 0.0101 0.0236
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0359
Loa Loa (eye worm) hypothetical protein 0.0015 0.0132 0.0309

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 100000 nM BindingDB_Patents: FLIPR Calcium Assay. Ca2+ influx was measured using a FLIPR calcium assay kit (R8033; Molecular Devices, Sunnyvale, Calif.). The Ca2+ indicator dye was dissolved in Hanks' balanced salt solution supplemented with 20 mM HEPES buffer (HBSS/HEPES) according to the manufacturer instructions. Prior to start of the assay, the medium was removed by aspiration, and cells were loaded with 100 µL Ca2+ dye for 2 to 3 hours at room temperature. AITC (allyl isothiocyanate) was used to activate and open the channels. (4×) solutions of the test compounds were prepared in HBSS/HEPES, and 50 µL were added to the cells at a delivery rate of 10 µL/sec. Changes in fluorescence were measured over time in a fluorometric imaging plate reader (FLIPR, Molecular Devices). Two additions were made over the course of an experimental run. For agonist experiments, assay buffer was added at the 10 s time point, followed by addition of agonist at the 3 minute 10 sec time point. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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