TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 488.58 | Formula: C31H28N4O2
H donors: 3 H acceptors: 4 LogP: 5.77 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC1CCC(CC1)Nc1cc(ccc1C(=O)N)c1ccnc2c1cccc2c1cnc2c(c1)cccc2
InChi: 1S/C31H28N4O2/c32-31(37)27-13-8-19(17-29(27)35-22-9-11-23(36)12-10-22)24-14-15-33-30-25(5-3-6-26(24)30)21-16-20-4-1-2-7-28(20)34-18-21/h1-8,13-18,22-23,35-36H,9-12H2,(H2,32,37)
InChiKey: YIVWGFSEBIRQAJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	heat shock protein 90kDa alpha (cytosolic), class A member 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Giardia lamblia	Heat shock protein HSP 90-alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Entamoeba histolytica	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Neospora caninum	HSP90, related	Get druggable targets OG5_126623	All targets in OG5_126623
Toxoplasma gondii	heat shock protein HSP90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania donovani	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania donovani	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein HSP 90-beta, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	hypothetical protein	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	putative heat shock protein 81-2	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	Get druggable targets OG5_126623	All targets in OG5_126623
Entamoeba histolytica	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Brugia malayi	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein HSP 90-alpha, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Cryptosporidium hominis	heat shock protein 83	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Neospora caninum	HSP90-like protein, related	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	ko:K09487 heat shock protein 90kDa beta, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium vivax	heat shock protein 86, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Loa Loa (eye worm)	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium knowlesi	endoplasmin, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Toxoplasma gondii	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium knowlesi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Brugia malayi	Endoplasmin precursor	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Loa Loa (eye worm)	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium berghei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	ko:K04079 molecular chaperone HtpG, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium falciparum	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Babesia bovis	hsp90 protein	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	heat shock 90 kDa protein homolog	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Giardia lamblia	Grp94/Hsp90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Cryptosporidium parvum	Hsp90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Theileria parva	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium ulcerans	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	heat shock protein 83,heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium vivax	endoplasmin, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Giardia lamblia	Heat shock protein HSP 90-alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Treponema pallidum	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	ecdysone induced protein 78C	0.0054	0.0286	0.0286
Onchocerca volvulus		0.0029	0.0061	0.0032
Onchocerca volvulus		0.0029	0.0061	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1071	0.1044
Loa Loa (eye worm)	PAN domain-containing protein	0.0029	0.0061	0.0032
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0025	0.003	0.003
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Brugia malayi	PAN domain containing protein	0.0029	0.0061	0.0061
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0054	0.0286	0.0286
Loa Loa (eye worm)	matrix metalloproteinase	0.0032	0.009	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0286	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1071	0.1044
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0054	0.0286	0.0286
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Onchocerca volvulus		0.0029	0.0061	0.0032
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0025	0.003	0.003
Brugia malayi	PAN domain containing protein	0.0029	0.0061	0.0061
Plasmodium falciparum	transporter, putative	0.0193	0.1532	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0193	0.1532	0.1532
Brugia malayi	hypothetical protein	0.0025	0.003	0.003
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0054	0.0286	0.0286
Onchocerca volvulus		0.0054	0.0286	0.0257
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0193	0.1532	0.1532
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0025	0.003	0.003
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0193	0.1532	0.1532
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0193	0.1532	0.1507
Schistosoma mansoni	thyroid hormone receptor	0.0054	0.0286	0.0286
Echinococcus granulosus	biogenic amine 5HT receptor	0.0141	0.1071	0.1071
Brugia malayi	hypothetical protein	0.0028	0.0057	0.0057
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0054	0.0286	0.0286
Echinococcus granulosus	disintegrin and metalloproteinase	0.0047	0.022	0.022
Schistosoma mansoni	nuclear receptor	0.0025	0.003	0.003
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0054	0.0286	0.0286
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0437	0.3731	0.3731
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0154	0.5
Trichomonas vaginalis	heat shock protein, putative	0.0039	0.0154	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0286	0.0257
Brugia malayi	Steroid receptor seven-up type 2	0.0054	0.0286	0.0286
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0054	0.0286	0.0257
Treponema pallidum	sodium- and chloride- dependent transporter	0.1134	1	1
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0193	0.1532	0.1532
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0054	0.0286	0.0286
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0025	0.003	0.003
Loa Loa (eye worm)	PAN domain-containing protein	0.0029	0.0061	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0286	0.0257
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0054	0.0286	0.0286
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0193	0.1532	0.1532
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0054	0.0286	0.0286
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0054	0.0286	0.0286
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0193	0.1532	0.1532
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0286	0.0257
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0054	0.0286	0.0286
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0154	0.5
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0054	0.0286	0.0286
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0041	0.0168	0.0139
Trypanosoma brucei	Heat shock protein 83, putative	0.0039	0.0154	0.5
Schistosoma mansoni	sodium/chloride dependent transporter	0.0193	0.1532	0.1532
Brugia malayi	nuclear receptor RXR	0.0025	0.003	0.003
Brugia malayi	Nuclear hormone receptor-like 1	0.0028	0.0057	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0193	0.1532	0.1507
Schistosoma mansoni	heat shock protein	0.0039	0.0154	0.0154
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0154	0.5
Toxoplasma gondii	PAN domain-containing protein	0.045	0.3843	1
Brugia malayi	MH2 domain containing protein	0.0074	0.0471	0.0471
Brugia malayi	photoreceptor-specific nuclear receptor	0.0054	0.0286	0.0286
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0193	0.1532	0.1532
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0054	0.0286	0.0286
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0032	0.009	0.009
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0054	0.0286	0.0286
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.0082	0.4732
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0154	0.5
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Brugia malayi	RNA binding protein	0.0041	0.0168	0.0168
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0054	0.0286	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0061	0.0032
Brugia malayi	PAN domain containing protein	0.0029	0.0061	0.0061
Brugia malayi	RNA recognition motif domain containing protein	0.0041	0.0168	0.0168
Echinococcus granulosus	heat shock protein 90	0.0039	0.0154	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0193	0.1532	0.1507
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0025	0.003	0.003
Loa Loa (eye worm)	matrixin family protein	0.0078	0.05	0.0472
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.1134	1	1
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0039	0.0153	1
Echinococcus multilocularis	geminin	0.0106	0.0752	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0032	0.009	0.0061
Schistosoma mansoni	hypothetical protein	0.0106	0.0752	0.0752
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0154	0.5
Plasmodium vivax	amine transporter, putative	0.0193	0.1532	1
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0193	0.1532	0.1532
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.0082	0.4732
Brugia malayi	hypothetical protein	0.0025	0.003	0.003
Echinococcus multilocularis	serotonin receptor	0.0141	0.1071	0.1071
Onchocerca volvulus	Matrilysin homolog	0.0032	0.009	0.0061
Trypanosoma brucei	heat shock protein 90, putative	0.0039	0.0154	0.5
Onchocerca volvulus		0.0029	0.0061	0.0032
Brugia malayi	Nuclear hormone receptor-like 1	0.0054	0.0286	0.0286
Brugia malayi	Endoplasmin precursor	0.0039	0.0154	0.0154
Echinococcus multilocularis	sodium channel protein	0.0051	0.0258	0.0258
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0437	0.3731	0.3731
Schistosoma mansoni	nuclear receptor nhr-48	0.0025	0.003	0.003
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Loa Loa (eye worm)	hypothetical protein	0.0032	0.009	0.0061
Schistosoma mansoni	tar DNA-binding protein	0.0041	0.0168	0.0168
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0025	0.003	0.003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0054	0.0286	0.0257
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0117	0.0852	0.0852
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0022	0.0003	0.0003
Brugia malayi	Serotonin receptor	0.0478	0.4097	0.4097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0054	0.0286	0.0257
Brugia malayi	Hemopexin family protein	0.0046	0.0211	0.0211
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0028	0.0057	0.0057
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0054	0.0286	0.0286
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0054	0.0286	0.0286
Plasmodium vivax	hypothetical protein, conserved	0.0193	0.1532	1
Brugia malayi	hypothetical protein	0.0028	0.0057	0.0057
Brugia malayi	nuclear receptor NHR-88	0.0025	0.003	0.003
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0051	0.0258	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0193	0.1532	0.389
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0193	0.1532	0.1532
Echinococcus granulosus	heat shock protein 90	0.0031	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0031	0.008	0.005
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0025	0.003	0.003
Loa Loa (eye worm)	matrixin family protein	0.0071	0.0442	0.0414
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Echinococcus granulosus	biogenic amine 5HT receptor	0.0437	0.3731	0.3731
Echinococcus multilocularis	heat shock protein	0.0039	0.0154	0.0154
Toxoplasma gondii	heat shock protein 90, putative	0.0039	0.0154	0.0245
Schistosoma mansoni	transcription factor LCR-F1	0.0022	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0193	0.1532	0.1507
Brugia malayi	PAN domain containing protein	0.0029	0.0061	0.0061
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.1077	0.9484	0.9484
Echinococcus granulosus	tar DNA binding protein	0.0041	0.0168	0.0168
Echinococcus multilocularis	endoplasmin	0.0031	0.0082	0.0082
Onchocerca volvulus	Protein ultraspiracle homolog	0.0054	0.0286	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0286	0.0257
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0025	0.003	0.003
Schistosoma mansoni	thyroid hormone receptor	0.0054	0.0286	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0057	0.0027
Trypanosoma cruzi	Heat shock protein 83, putative	0.0039	0.0154	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0025	0.003	0.003
Loa Loa (eye worm)	serotonin transporter b	0.1134	1	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0025	0.003	0.003
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0054	0.0286	0.0286
Brugia malayi	PAN domain containing protein	0.0029	0.0061	0.0061
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0025	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.1134	1	1
Brugia malayi	PAN domain containing protein	0.0029	0.0061	0.0061
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0047	0.022	0.022
Schistosoma mansoni	hypothetical protein	0.0106	0.0752	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0153	0.0124
Loa Loa (eye worm)	endoplasmin	0.0039	0.0154	0.0125
Schistosoma mansoni	tar DNA-binding protein	0.0041	0.0168	0.0168
Onchocerca volvulus		0.0193	0.1532	0.1507
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0057	0.0027
Schistosoma mansoni	zinc finger protein	0.0025	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0286	0.0257
Onchocerca volvulus		0.0029	0.0061	0.0032
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0039	0.0153	0.0153
Echinococcus granulosus	nuclear receptor nhr 48	0.0025	0.003	0.003
Trypanosoma cruzi	heat shock protein 90, putative	0.0039	0.0154	1
Plasmodium falciparum	heat shock protein 90	0.0039	0.0154	0.0901
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0054	0.0286	0.0286
Schistosoma mansoni	hypothetical protein	0.0022	0.0003	0.0003
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Brugia malayi	PAN domain containing protein	0.0029	0.0061	0.0061
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Schistosoma mansoni	hypothetical protein	0.0046	0.0211	0.0211
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0025	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0057	0.0027
Echinococcus multilocularis	nuclear receptor nhr 48	0.0025	0.003	0.003
Brugia malayi	PAN domain containing protein	0.0029	0.0061	0.0061
Echinococcus granulosus	sodium and chloride dependent glycine	0.0193	0.1532	0.1532
Brugia malayi	Matrixin family protein	0.0032	0.009	0.009
Loa Loa (eye worm)	PAN domain-containing protein	0.0029	0.0061	0.0032
Echinococcus multilocularis	serotonin transporter	0.1134	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0054	0.0286	0.0286
Schistosoma mansoni	nuclear receptor	0.0025	0.003	0.003
Schistosoma mansoni	RAR-like nuclear receptor	0.0054	0.0286	0.0286
Onchocerca volvulus		0.0029	0.0061	0.0032
Schistosoma mansoni	sodium/chloride dependent transporter	0.1134	1	1
Brugia malayi	steroid hormone receptor	0.0054	0.0286	0.0286
Loa Loa (eye worm)	PAN domain-containing protein	0.0029	0.0061	0.0032
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0054	0.0286	0.0286
Onchocerca volvulus		0.0193	0.1532	0.1507
Brugia malayi	nuclear receptor NHR-88	0.0054	0.0286	0.0286
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0031	0.0082	0.5
Loa Loa (eye worm)	RNA binding protein	0.0041	0.0168	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0193	0.1532	0.1507
Loa Loa (eye worm)	norepinephrine transporter	0.1134	1	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0025	0.003	0.003
Trypanosoma cruzi	heat shock protein 85, putative	0.0031	0.0082	0.503
Loa Loa (eye worm)	solute carrier family 6 member 4	0.1134	1	1
Onchocerca volvulus		0.0029	0.0061	0.0032
Onchocerca volvulus	Bile acid receptor homolog	0.0054	0.0286	0.0257
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0193	0.1532	0.1532
Brugia malayi	Matrixin family protein	0.0032	0.009	0.009
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0193	0.1532	0.1532
Schistosoma mansoni	nuclear hormone receptor	0.0025	0.003	0.003
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0061	0.0032
Loa Loa (eye worm)	disintegrin family protein	0.0034	0.0106	0.0076
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0054	0.0286	0.0286
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Schistosoma mansoni	dihydroceramide desaturase	0.0047	0.022	0.022
Toxoplasma gondii	hypothetical protein	0.0193	0.1532	0.389
Loa Loa (eye worm)	PAN domain-containing protein	0.0029	0.0061	0.0032
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0054	0.0286	0.0286
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0193	0.1532	0.1532
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0054	0.0286	0.0257
Onchocerca volvulus		0.0029	0.0061	0.0032
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0193	0.1532	0.1532
Brugia malayi	Matrixin family protein	0.0078	0.05	0.05
Loa Loa (eye worm)	heat shock protein 90	0.0039	0.0154	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0061	0.0032
Brugia malayi	tailless protein	0.0025	0.003	0.003
Brugia malayi	ecdysteroid receptor	0.0054	0.0286	0.0286
Echinococcus granulosus	ecdysone induced protein 78C	0.0054	0.0286	0.0286
Onchocerca volvulus		0.1134	1	1
Brugia malayi	Disintegrin family protein	0.0047	0.022	0.022
Brugia malayi	TAR-binding protein	0.0041	0.0168	0.0168
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0054	0.0286	0.0257
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0117	0.0852	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0032	0.009	0.0061
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0031	0.0082	0.0082
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0054	0.0286	0.0286
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0054	0.0286	0.0286
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0193	0.1532	0.389
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0193	0.1532	0.1532
Onchocerca volvulus		0.0029	0.0061	0.0032
Brugia malayi	hypothetical protein	0.0022	0.0003	0.0003
Brugia malayi	Nuclear hormone receptor E75	0.0025	0.003	0.003
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0193	0.1532	0.1532
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0054	0.0286	0.0286
Echinococcus granulosus	Blood coagulation inhibitor Disintegrin	0.0031	0.008	0.008
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0028	0.0057	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0061	0.0032
Trypanosoma cruzi	heat shock protein 85, putative	0.0039	0.0154	1
Echinococcus multilocularis	heat shock protein 90	0.0039	0.0154	0.0154
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0054	0.0286	0.0257
Schistosoma mansoni	endoplasmin	0.0039	0.0154	0.0154
Echinococcus granulosus	FTZ F1 alpha	0.0054	0.0286	0.0286
Echinococcus multilocularis	heat shock protein 90	0.0031	0.0082	0.0082
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Onchocerca volvulus	Matrilysin homolog	0.0071	0.0442	0.0414
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0193	0.1532	0.389
Schistosoma mansoni	tar DNA-binding protein	0.0041	0.0168	0.0168
Loa Loa (eye worm)	transcription factor SMAD2	0.0074	0.0471	0.0442
Echinococcus multilocularis	tar DNA binding protein	0.0041	0.0168	0.0168
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0193	0.1532	0.1532
Brugia malayi	PAN domain containing protein	0.0029	0.0061	0.0061
Trypanosoma cruzi	heat shock protein 90, putative	0.0031	0.0082	0.503
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0286	0.0257
Trypanosoma brucei	heat shock protein 90, putative	0.0039	0.0154	0.5
Schistosoma mansoni	coup transcription factor	0.0054	0.0286	0.0286
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0193	0.1532	0.1532
Onchocerca volvulus		0.0193	0.1532	0.1507
Loa Loa (eye worm)	steroid hormone receptor	0.0054	0.0286	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0193	0.1532	0.1507
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0286	0.0257
Toxoplasma gondii	PAN domain-containing protein	0.045	0.3843	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0054	0.0286	0.0286
Brugia malayi	heat shock protein 90	0.0039	0.0154	0.0154
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0193	0.1532	0.1532
Schistosoma mansoni	sodium/chloride dependent transporter	0.0193	0.1532	0.1532
Brugia malayi	orphan nuclear receptor NR2E1	0.0025	0.003	0.003
Brugia malayi	PAN domain containing protein	0.0029	0.0061	0.0061
Schistosoma mansoni	endoplasmin	0.0039	0.0154	0.0154
Loa Loa (eye worm)	hypothetical protein	0.1134	1	1
Brugia malayi	nuclear receptor RXR	0.0028	0.0057	0.0057
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Brugia malayi	nuclear hormone receptor	0.0054	0.0286	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0061	0.0032
Loa Loa (eye worm)	hypothetical protein	0.1134	1	1
Plasmodium falciparum	amino acid transporter, putative	0.0193	0.1532	1
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0154	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0054	0.0286	0.0286
Schistosoma mansoni	heat shock protein	0.0039	0.0154	0.0154
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0154	0.5
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0028	0.0057	0.0027
Echinococcus multilocularis	Blood coagulation inhibitor, Disintegrin	0.0031	0.008	0.008
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0054	0.0286	0.0257
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Onchocerca volvulus		0.0032	0.009	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0193	0.1532	0.1507
Echinococcus granulosus	sodium channel protein	0.0051	0.0258	0.0258
Brugia malayi	Nuclear hormone receptor E75	0.0025	0.003	0.003
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0054	0.0286	0.0286
Schistosoma mansoni	nuclear hormone receptor	0.0054	0.0286	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0061	0.0032
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0039	0.0154	1
Loa Loa (eye worm)	TAR-binding protein	0.0041	0.0168	0.0139
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0193	0.1532	0.1507
Brugia malayi	hypothetical protein	0.0193	0.1532	0.1532
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.0082	0.4732
Mycobacterium leprae	PROBABLE HYDROLASE	0.0039	0.0153	1
Toxoplasma gondii	heat shock protein HSP90	0.0039	0.0154	0.0245
Toxoplasma gondii	hypothetical protein	0.0193	0.1532	0.389
Loa Loa (eye worm)	hypothetical protein	0.0193	0.1532	0.1507
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0022	0.0003	0.0003
Trypanosoma cruzi	heat shock protein 85, putative	0.0039	0.0154	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0054	0.0286	0.0286
Echinococcus granulosus	heat shock protein	0.0039	0.0154	0.0154
Echinococcus granulosus	serotonin transporter	0.1134	1	1
Brugia malayi	ecdysone receptor	0.0025	0.003	0.003
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Onchocerca volvulus		0.0046	0.0211	0.0182
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0054	0.0286	0.0286
Schistosoma mansoni	tar DNA-binding protein	0.0041	0.0168	0.0168
Echinococcus multilocularis	serotonin receptor	0.0141	0.1071	0.1071
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0028	0.0057	0.0057
Onchocerca volvulus		0.0029	0.0061	0.0032
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0193	0.1532	0.1532
Entamoeba histolytica	heat shock protein 90, putative	0.0039	0.0154	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0054	0.0286	0.0286
Mycobacterium ulcerans	hydrolase	0.0039	0.0153	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0039	0.0154	1
Entamoeba histolytica	heat shock protein 90, putative	0.0039	0.0154	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0193	0.1532	0.1532
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0193	0.1532	0.1532
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0057	0.0027
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0028	0.0057	0.0057
Schistosoma mansoni	tar DNA-binding protein	0.0041	0.0168	0.0168
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0193	0.1532	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0074	0.0471	0.0442
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0193	0.1532	0.1532
Brugia malayi	Nuclear hormone receptor-like 1	0.0028	0.0057	0.0057
Schistosoma mansoni	nuclear hormone receptor	0.0025	0.003	0.003
Brugia malayi	nuclear hormone receptor	0.0025	0.003	0.003
Echinococcus granulosus	thyroid hormone receptor alpha	0.0025	0.003	0.003
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0054	0.0286	0.0257
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0054	0.0286	0.0286
Echinococcus granulosus	sodium and chloride dependent glycine	0.0193	0.1532	0.1532
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0071	0.0442	0.0414
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0054	0.0286	0.0286
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0054	0.0286	0.0286
Brugia malayi	Matrixin family protein	0.0032	0.009	0.009
Echinococcus granulosus	geminin	0.0106	0.0752	0.0752
Brugia malayi	conserved hypotetical protein	0.0025	0.003	0.003
Onchocerca volvulus		0.0029	0.0061	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0061	0.0032
Leishmania major	heat shock protein 83-1	0.0039	0.0154	0.4082
Brugia malayi	Matrixin family protein	0.0032	0.009	0.009
Echinococcus multilocularis	disintegrin and metalloproteinase	0.0047	0.022	0.022
Echinococcus granulosus	endoplasmin	0.0031	0.0082	0.0082
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0051	0.0258	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0057	0.0027
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0141	0.1071	0.1071
Echinococcus multilocularis	FTZ F1 alpha	0.0054	0.0286	0.0286
Brugia malayi	nuclear receptor NHR-67	0.0025	0.003	0.003
Trypanosoma brucei	heat shock protein, putative	0.0039	0.0154	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0054	0.0286	0.0286

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 290 nM	BindingDB_Patents: AlphaScreen Competitive Assay. HSP90-binding activity was determined by an AlphaScreen competitive assay system. The purified HSP90 solution was diluted with a binding buffer (50 mM Tris-HCl (pH 7.5), 150 mM NaCl, 0.1% Triton-X 100, 1 mM DTT, 0.1% BSA) and added to a 384-well plate (#3673, Corning Inc.) containing test substances. After reaction at room temperature for 2 hours, biotinylated geldanamycin was added thereto at a concentration of 40 nM/well and further reacted for 1 hour. Detection mix (20 mM HEPES-KOH (pH 7.5), 0.5% BSA, 0.04 mg/mL Nickel Chelate Acceptor beads, 0.04 mg/mL Streptavidin-coated Donor beads) (#6760619C, PerkinElmer, Inc.) was added to each well in an amount equal to the amount of the reaction solution and reacted at room temperature for 1 hour in the dark. Then, fluorescence intensity was measured using Multilabel Plate Reader EnVision (PerkinElmer, Inc.).	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3653943

Bibliographic References

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Detailed information for compound 2000168