Detailed information for compound 203547

Basic information

Technical information
  • TDR Targets ID: 203547
  • Name: 7-chloro-2-methyl-3-[4-(trifluoromethyl)pheny l]-2,3,4,10-tetrahydroacridine-1,9-dione
  • MW: 405.798 | Formula: C21H15ClF3NO2
  • H donors: 1 H acceptors: 3 LogP: 6 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)c(O)c1c(n2)CC(C(C1=O)C)c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C21H15ClF3NO2/c1-10-14(11-2-4-12(5-3-11)21(23,24)25)9-17-18(19(10)27)20(28)15-8-13(22)6-7-16(15)26-17/h2-8,10,14H,9H2,1H3,(H,26,28)
  • InChiKey: HSCRNHUFGOUESH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-chloro-2-methyl-3-[4-(trifluoromethyl)phenyl]-2,3,4,10-tetrahydroacridine-1,9-quinone
  • 7-Chloro-3,4-dihydro-2-methyl-3-[4-[trifluoromethyl]phenyl]-1,9(2H,10H)-acridinedione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-lactamase 0.0075 0.0761 0.0761
Loa Loa (eye worm) hypothetical protein 0.0066 0.0607 0.0607
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0761 0.1689
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0235 0.3443 0.7611
Loa Loa (eye worm) hypothetical protein 0.008 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0235 0.3443 0.3443
Loa Loa (eye worm) doublecortin family protein 0.0062 0.054 0.054
Loa Loa (eye worm) TK/EGFR protein kinase 0.0145 0.1933 0.1933
Loa Loa (eye worm) hypothetical protein 0.0075 0.0761 0.0761
Loa Loa (eye worm) hypothetical protein 0.0072 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.0054 0.0415 0.0415
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0196 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0152 0.2057 0.2057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0152 0.2057 0.2057
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.0808 0.1824
Brugia malayi conserved hypotetical protein 0.0072 0.0707 0.0707
Brugia malayi Carboxylesterase family protein 0.0066 0.0607 0.0607
Loa Loa (eye worm) TK/INSR protein kinase 0.0046 0.0279 0.0279
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0171 0.0171
Brugia malayi beta-lactamase family protein 0.0075 0.0761 0.0761
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0174 0.2425 0.2425
Brugia malayi hypothetical protein 0.008 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0171
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0122 0.1555 0.1555
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.0707 0.1535
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0761 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0152 0.2057 0.2057
Schistosoma mansoni jun-related protein 0.02 0.2861 0.6256
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0179 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0152 0.2057 0.2057
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0152 0.2057 0.4741
Onchocerca volvulus 0.0152 0.2057 0.5763
Plasmodium falciparum carbonic anhydrase 0.0082 0.0875 1
Schistosoma mansoni retinoic acid receptor RXR 0.0248 0.3664 0.8124
Brugia malayi P38 map kinase family protein 2 0.0122 0.1555 0.1555
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0359 0.0359
Loa Loa (eye worm) nuclear hormone receptor 0.0072 0.0707 0.0707
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0702 0.1519
Onchocerca volvulus 0.0051 0.0359 0.0574
Schistosoma mansoni carbonic anhydrase-related 0.0082 0.0875 0.1637
Echinococcus multilocularis carbonic anhydrase 0.0082 0.0875 0.177
Loa Loa (eye worm) hypothetical protein 0.008 0.0852 0.0852
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0432 0.0432
Trypanosoma brucei carbonic anhydrase-like protein 0.0174 0.2425 1
Schistosoma mansoni cell polarity protein 0.0047 0.0294 0.0285
Brugia malayi hypothetical protein 0.0194 0.2748 0.2748
Loa Loa (eye worm) hypothetical protein 0.0152 0.2057 0.2057
Loa Loa (eye worm) hypothetical protein 0.008 0.0852 0.0852
Echinococcus granulosus carbonic anhydrase 0.0082 0.0875 0.2015
Loa Loa (eye worm) glutaminase 0.0296 0.447 0.447
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0046 0.0279 0.0309
Schistosoma mansoni tyrosine kinase 0.0078 0.0808 0.1482
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0432 0.0432
Entamoeba histolytica hypothetical protein 0.0074 0.0742 1
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.0808 0.1602
Schistosoma mansoni peroxidasin 0.0051 0.0359 0.0437
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.0359
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.0707 0.1348
Schistosoma mansoni carbonic anhydrase-related 0.0082 0.0875 0.1637
Echinococcus granulosus slit 2 protein 0.0064 0.057 0.1144
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0152 0.2057 0.2057
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.024 0.3522 0.3522
Schistosoma mansoni loxhd1 0.0062 0.054 0.0858
Echinococcus multilocularis thyroid hormone receptor alpha 0.0277 0.4149 1
Schistosoma mansoni tyrosine kinase 0.0077 0.0794 0.145
Onchocerca volvulus Peroxidase homolog 0.0051 0.0359 0.0574
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1594 0.4074
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0072 0.0707 0.1247
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0082 0.0875 0.0875
Schistosoma mansoni nuclear receptor 0.0072 0.0707 0.1247
Schistosoma mansoni carbonic anhydrase 0.0082 0.0875 0.1637
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0152 0.2057 0.2057
Toxoplasma gondii hypothetical protein 0.0082 0.0875 1
Echinococcus multilocularis geminin 0.0184 0.2582 0.6061
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0359 0.0359
Loa Loa (eye worm) blistered cuticle protein 3 0.0051 0.0359 0.0359
Schistosoma mansoni hypothetical protein 0.0082 0.0875 0.1637
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0359 0.0359
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0196 0.0073
Loa Loa (eye worm) hypothetical protein 0.0072 0.0707 0.0707
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0702 0.1334
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0761 0.0761
Echinococcus granulosus jun protein 0.0246 0.3635 0.9918
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0241 0.3549 0.9671
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.008 0.0852 0.1583
Brugia malayi nuclear hormone receptor family member nhr-6 0.0072 0.0707 0.0707
Schistosoma mansoni tyrosine kinase 0.0077 0.0794 0.145
Brugia malayi Serotonin receptor 0.0473 0.7427 0.7427
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0174 0.2425 0.5242
Loa Loa (eye worm) hypothetical protein 0.0064 0.057 0.057
Schistosoma mansoni nuclear hormone receptor 0.0152 0.2057 0.4386
Brugia malayi hypothetical protein 0.008 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0082 0.0875 0.0875
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0761 0.0344
Schistosoma mansoni thyroid hormone receptor 0.0277 0.4149 0.9252
Echinococcus multilocularis ecdysone induced protein 78C 0.0152 0.2057 0.4741
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.054 0.1057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.008 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0075 0.0761 0.0761
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.0359
Onchocerca volvulus 0.0062 0.054 0.1128
Plasmodium falciparum LCCL domain-containing protein 0.0062 0.054 0.5243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0152 0.2057 0.2057
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0082 0.0875 0.0875
Schistosoma mansoni hypothetical protein 0.0184 0.2582 0.5607
Schistosoma mansoni sodium/chloride dependent transporter 0.0235 0.3443 0.7611
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0702 0.1234
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0171 0.0171
Schistosoma mansoni thyroid hormone receptor 0.0277 0.4149 0.9252
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0761 0.1372
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.0359
Echinococcus granulosus neurogenic locus notch protein 0.0047 0.0294 0.0351
Loa Loa (eye worm) hypothetical protein 0.0152 0.2057 0.2057
Loa Loa (eye worm) hypothetical protein 0.0152 0.2057 0.2057
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0122 0.1555 0.4951
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.0359
Onchocerca volvulus 0.0072 0.0707 0.1638
Loa Loa (eye worm) serotonin transporter b 0.0235 0.3443 0.3443
Echinococcus granulosus carbonic anhydrase 0.0082 0.0875 0.2015
Brugia malayi orphan nuclear receptor NR2E1 0.0072 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.0359
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0122 0.1555 0.4951
Echinococcus granulosus mitogen activated protein kinase 11 0.0122 0.1555 0.3962
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0152 0.2057 0.4741
Loa Loa (eye worm) hypothetical protein 0.0072 0.0707 0.0707
Echinococcus granulosus ecdysone induced protein 78C 0.0152 0.2057 0.5399
Brugia malayi hypothetical protein 0.004 0.0171 0.0171
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0072 0.0707 0.0707
Onchocerca volvulus Bile acid receptor homolog 0.0152 0.2057 0.5763
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0761 0.5
Loa Loa (eye worm) hypothetical protein 0.0626 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0152 0.2057 0.2057
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0152 0.2057 0.2057
Schistosoma mansoni nuclear hormone receptor 0.0072 0.0707 0.1247
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0152 0.2057 0.4386
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.0808 0.1824
Schistosoma mansoni intermediate filament proteins 0.0055 0.0432 0.0606
Onchocerca volvulus Protein ultraspiracle homolog 0.0152 0.2057 0.5763
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0607 0.1096
Onchocerca volvulus 0.0055 0.0432 0.0797
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.008 0.0852 0.1949
Echinococcus granulosus geminin 0.0184 0.2582 0.6902
Echinococcus multilocularis musashi 0.0055 0.0432 0.0655
Brugia malayi nuclear receptor NHR-88 0.0152 0.2057 0.2057
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0072 0.0707 0.1247
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0246 0.3635 0.8709
Echinococcus granulosus nuclear factor of activated T cells 5 0.0145 0.1926 0.5025
Echinococcus granulosus Polycystic kidney disease protein 0.0062 0.054 0.1057
Loa Loa (eye worm) animal heme peroxidase 0.0051 0.0359 0.0359
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0152 0.2057 0.4741
Brugia malayi intermediate filament protein 0.0055 0.0432 0.0432
Brugia malayi hypothetical protein 0.0062 0.054 0.054
Echinococcus multilocularis carbonic anhydrase 0.0082 0.0875 0.177
Brugia malayi nuclear hormone receptor family member odr-7 0.0072 0.0707 0.0707
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0359 0.0359
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0171 0.0171
Brugia malayi ecdysone receptor 0.0072 0.0707 0.0707
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0607 0.1248
Echinococcus granulosus Nuclear hormone receptor HR96 0.0072 0.0707 0.1535
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0171
Schistosoma mansoni steroid hormone receptor ad4bp 0.0152 0.2057 0.4386
Echinococcus granulosus Nuclear hormone receptor HR96 0.0072 0.0707 0.1535
Loa Loa (eye worm) hypothetical protein 0.0075 0.0761 0.0761
Schistosoma mansoni slit 0.0064 0.057 0.0929
Schistosoma mansoni nuclear receptor nhr-48 0.0072 0.0707 0.1247
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.0852 0.0852
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0607 0.1096
Echinococcus granulosus lamin 0.0055 0.0432 0.0746
Loa Loa (eye worm) carbonic anhydrase 3 0.0174 0.2425 0.2425
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0152 0.2057 0.2057
Schistosoma mansoni polycystin 1-related 0.0062 0.054 0.0858
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0235 0.3443 0.3443
Brugia malayi Nuclear hormone receptor E75 0.0072 0.0707 0.0707
Echinococcus multilocularis neurogenic locus notch protein 0.0047 0.0294 0.0308
Onchocerca volvulus 0.0072 0.0707 0.1638
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0152 0.2057 0.2057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0152 0.2057 0.2057
Schistosoma mansoni tyrosine kinase 0.0145 0.1933 0.4098
Mycobacterium ulcerans glutaminase 0.0296 0.447 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.048 0.7546 1
Echinococcus granulosus acetylcholinesterase 0.0066 0.0607 0.1248
Leishmania major hypothetical protein, conserved 0.0075 0.0761 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0152 0.2057 0.2057
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0742 0.1329
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0171
Echinococcus granulosus nuclear receptor nhr 48 0.0072 0.0707 0.1535
Schistosoma mansoni glutaminase 0.0296 0.447 1
Brugia malayi nuclear receptor RXR 0.008 0.0852 0.0852
Brugia malayi Cytochrome P450 family protein 0.0061 0.0517 0.0517
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.004 0.0171 0.0171
Echinococcus granulosus carbonic anhydrase II 0.0174 0.2425 0.6452
Onchocerca volvulus 0.0075 0.0761 0.1803
Schistosoma mansoni rab6-interacting 0.0062 0.054 0.0858
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.008 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0075 0.0761 0.0761
Onchocerca volvulus 0.0235 0.3443 1
Echinococcus multilocularis FTZ F1 alpha 0.0152 0.2057 0.4741
Schistosoma mansoni carbonic anhydrase-related 0.0082 0.0875 0.1637
Schistosoma mansoni hypothetical protein 0.02 0.2861 0.6256
Echinococcus multilocularis carbonic anhydrase 0.0082 0.0875 0.177
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0171
Brugia malayi nuclear receptor NHR-88 0.0072 0.0707 0.0707
Onchocerca volvulus 0.0051 0.0359 0.0574
Schistosoma mansoni lamin 0.0055 0.0432 0.0606
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0174 0.2425 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0152 0.2057 0.4386
Schistosoma mansoni nuclear hormone receptor 0.0072 0.0707 0.1247
Schistosoma mansoni coup transcription factor 0.0152 0.2057 0.4386
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0432 0.0432
Echinococcus multilocularis mitogen activated protein kinase 14 0.0122 0.1555 0.3479
Brugia malayi Protein kinase domain containing protein 0.0046 0.0279 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0152 0.2057 0.2057
Brugia malayi hypothetical protein 0.0072 0.0707 0.0707
Schistosoma mansoni tyrosine kinase 0.0077 0.0794 0.145
Brugia malayi Doublecortin family protein 0.0062 0.054 0.054
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0152 0.2057 0.5399
Echinococcus multilocularis Polycystic kidney disease protein 0.0062 0.054 0.0928
Loa Loa (eye worm) hypothetical protein 0.0152 0.2057 0.2057
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0174 0.2425 0.5242
Echinococcus multilocularis epidermal growth factor receptor 0.0145 0.1933 0.443
Echinococcus multilocularis slit 2 protein 0.0064 0.057 0.1004
Echinococcus granulosus thyroid hormone receptor alpha 0.0072 0.0707 0.1535
Brugia malayi Steroid receptor seven-up type 2 0.0152 0.2057 0.2057
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.004 0.0171 0.5
Loa Loa (eye worm) hypothetical protein 0.0152 0.2057 0.2057
Loa Loa (eye worm) solute carrier family 6 member 4 0.0235 0.3443 0.3443
Echinococcus multilocularis mitogen activated protein kinase 14 0.0122 0.1555 0.3479
Brugia malayi beta-lactamase 0.0075 0.0761 0.0761
Loa Loa (eye worm) hypothetical protein 0.0062 0.054 0.054
Brugia malayi EGF-like domain containing protein 0.0064 0.057 0.057
Schistosoma mansoni hypothetical protein 0.0184 0.2582 0.5607
Brugia malayi Carboxylesterase family protein 0.0066 0.0607 0.0607
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.054 0.1057
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0145 0.1926 0.4412
Echinococcus granulosus RUN 0.0062 0.054 0.1057
Echinococcus multilocularis pikachurin 0.0047 0.0294 0.0308
Schistosoma mansoni rab6-interacting 0.0062 0.054 0.0858
Schistosoma mansoni hypothetical protein 0.0074 0.0742 0.1329
Brugia malayi hypothetical protein 0.0051 0.0359 0.0359
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0246 0.3635 0.9918
Brugia malayi ecdysteroid receptor 0.0152 0.2057 0.2057
Loa Loa (eye worm) hypothetical protein 0.0072 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.0072 0.0707 0.0707
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0152 0.2057 0.4741
Onchocerca volvulus Peroxidase homolog 0.0051 0.0359 0.0574
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0152 0.2057 0.2057
Brugia malayi nuclear receptor RXR 0.0072 0.0707 0.0707
Schistosoma mansoni lamin 0.0055 0.0432 0.0606
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0241 0.3549 0.8492
Brugia malayi Blistered cuticle protein 3 0.0051 0.0359 0.0359
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0359 0.0359
Echinococcus granulosus pikachurin 0.0047 0.0294 0.0351
Schistosoma mansoni hypothetical protein 0.0056 0.0442 0.063
Schistosoma mansoni lipoxygenase 0.0241 0.3549 0.7857
Echinococcus granulosus intermediate filament protein 0.0055 0.0432 0.0746
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0082 0.0875 0.0875
Brugia malayi Furin-like cysteine rich region family protein 0.0145 0.1933 0.1933
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0171 0.0171
Echinococcus multilocularis peroxidasin 0.0051 0.0359 0.0473
Loa Loa (eye worm) hypothetical protein 0.0072 0.0707 0.0707
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0082 0.0875 0.0875
Loa Loa (eye worm) hypothetical protein 0.0072 0.0707 0.0707
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1594 0.3577
Toxoplasma gondii ABC1 family protein 0.0075 0.0761 0.8382
Echinococcus granulosus acetylcholinesterase 0.0066 0.0607 0.1248
Loa Loa (eye worm) DR-78 0.0072 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.0062 0.054 0.054
Brugia malayi nuclear hormone receptor 0.0072 0.0707 0.0707
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0607 0.1014
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0047 0.0294 0.0285
Loa Loa (eye worm) hypothetical protein 0.0072 0.0707 0.0707
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0152 0.2057 0.4386
Loa Loa (eye worm) hypothetical protein 0.0072 0.0707 0.0707
Echinococcus granulosus peroxidasin 0.0051 0.0359 0.0538
Loa Loa (eye worm) hypothetical protein 0.0072 0.0707 0.0707
Echinococcus multilocularis insulin receptor 0.0046 0.0279 0.0271
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0072 0.0707 0.0707
Echinococcus multilocularis RUN 0.0062 0.054 0.0928
Echinococcus multilocularis mitogen activated protein kinase 11 0.0122 0.1555 0.3479
Loa Loa (eye worm) glutaminase 2 0.0296 0.447 0.447
Loa Loa (eye worm) hypothetical protein 0.0055 0.0432 0.0432
Schistosoma mansoni hypothetical protein 0.0125 0.1594 0.331
Echinococcus granulosus mitogen activated protein kinase 14 0.0122 0.1555 0.3962
Schistosoma mansoni tyrosine kinase 0.0046 0.0279 0.0251
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0152 0.2057 0.5399
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0072 0.0707 0.1535
Echinococcus multilocularis carbonic anhydrase II 0.0174 0.2425 0.5666
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0046 0.0279 0.0271
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0082 0.0875 0.0875
Trichomonas vaginalis glutaminase, putative 0.0296 0.447 1
Brugia malayi nuclear hormone receptor 0.0152 0.2057 0.2057
Onchocerca volvulus Peroxidasin homolog 0.0051 0.0359 0.0574
Echinococcus multilocularis lamin 0.0055 0.0432 0.0655
Brugia malayi Nuclear hormone receptor E75 0.0072 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.0152 0.2057 0.2057
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0152 0.2057 0.4741
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.0359
Onchocerca volvulus Chorion peroxidase homolog 0.0051 0.0359 0.0574
Echinococcus multilocularis nuclear receptor nhr 48 0.0072 0.0707 0.1348
Schistosoma mansoni hypothetical protein 0.0062 0.054 0.0858
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0152 0.2057 0.5763
Loa Loa (eye worm) steroid hormone receptor 0.0152 0.2057 0.2057
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0761 0.0344
Brugia malayi Nuclear hormone receptor-like 1 0.0152 0.2057 0.2057
Loa Loa (eye worm) hypothetical protein 0.0075 0.0761 0.0761
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0152 0.2057 0.4386
Schistosoma mansoni tyrosine kinase 0.0046 0.0279 0.0251
Onchocerca volvulus 0.0194 0.2748 0.7874
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0152 0.2057 0.2057
Echinococcus multilocularis serotonin transporter 0.0235 0.3443 0.8227
Schistosoma mansoni nuclear receptor 0.0072 0.0707 0.1247
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.0517 0.0517
Brugia malayi beta-lactamase family protein 0.0075 0.0761 0.0761
Echinococcus multilocularis mitogen activated protein kinase 11 0.0122 0.1555 0.3479
Schistosoma mansoni retinoid-x-receptor (RXR) 0.008 0.0852 0.1583
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0152 0.2057 0.4741
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0152 0.2057 0.5399
Brugia malayi laminin-like protein K08C7.3 precursor 0.0047 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.0235 0.3443 0.3443
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0607 0.1096
Echinococcus multilocularis 0.0045 0.0254 0.021
Loa Loa (eye worm) hypothetical protein 0.0152 0.2057 0.2057
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0761 0.0761
Loa Loa (eye worm) norepinephrine transporter 0.0235 0.3443 0.3443
Brugia malayi hypothetical protein 0.0074 0.0742 0.0742
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.0359
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0152 0.2057 0.2057
Entamoeba histolytica hypothetical protein 0.0074 0.0742 1
Echinococcus granulosus carbonic anhydrase 0.0082 0.0875 0.2015
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0122 0.1555 0.4951
Schistosoma mansoni lipoxygenase 0.013 0.168 0.351
Loa Loa (eye worm) hypothetical protein 0.0082 0.0875 0.0875
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0072 0.0707 0.0707
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0152 0.2057 0.2057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0152 0.2057 0.5399
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.0359
Onchocerca volvulus 0.0075 0.0761 0.1803
Loa Loa (eye worm) hypothetical protein 0.0066 0.0607 0.0607
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0072 0.0707 0.1348
Echinococcus granulosus epidermal growth factor receptor 0.0145 0.1933 0.5045
Loa Loa (eye worm) hypothetical protein 0.0082 0.0875 0.0875
Loa Loa (eye worm) carboxylesterase 0.0066 0.0607 0.0607
Echinococcus multilocularis jun protein 0.0246 0.3635 0.8709
Schistosoma mansoni peroxidasin 0.0051 0.0359 0.0437
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0152 0.2057 0.5399
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0152 0.2057 0.5399
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0072 0.0707 0.1638
Schistosoma mansoni laminin gamma-3 chain 0.0064 0.057 0.0929
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0072 0.0707 0.1348
Loa Loa (eye worm) hypothetical protein 0.0075 0.0761 0.0761
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0082 0.0875 0.0875
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0152 0.2057 0.2057
Echinococcus granulosus serotonin transporter 0.0235 0.3443 0.9369
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0072 0.0707 0.1638
Schistosoma mansoni tyrosine kinase 0.0078 0.0808 0.1482
Entamoeba histolytica hypothetical protein 0.0074 0.0742 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.054 0.0928
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0761 0.1483
Loa Loa (eye worm) hypothetical protein 0.0428 0.6677 0.6677
Loa Loa (eye worm) abnormal epIthelia family member 0.0047 0.0294 0.0294
Onchocerca volvulus 0.0055 0.0432 0.0797
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0171
Mycobacterium leprae Probable lipase LipE 0.0075 0.0761 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0152 0.2057 0.4386
Loa Loa (eye worm) hypothetical protein 0.008 0.0852 0.0852
Brugia malayi photoreceptor-specific nuclear receptor 0.0152 0.2057 0.2057
Onchocerca volvulus 0.0051 0.0359 0.0574
Loa Loa (eye worm) hypothetical protein 0.0072 0.0707 0.0707
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0761 0.1372
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0702 0.0702
Plasmodium vivax multidomain scavenger receptor, putative 0.0062 0.054 0.6255
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.0359
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0168 0.2314 0.5388
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0761 0.0344
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0702 0.0702
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0122 0.1555 0.4951
Echinococcus granulosus insulin receptor 0.0046 0.0279 0.0309
Entamoeba histolytica hypothetical protein 0.0074 0.0742 1
Loa Loa (eye worm) hypothetical protein 0.0428 0.6677 0.6677
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0248 0.3664 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0174 0.2425 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0152 0.2057 0.4386
Loa Loa (eye worm) hypothetical protein 0.0072 0.0707 0.0707
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0174 0.2425 0.2425
Treponema pallidum sodium- and chloride- dependent transporter 0.0235 0.3443 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0152 0.2057 0.2057
Onchocerca volvulus 0.0075 0.0761 0.1803
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0152 0.2057 0.4386
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.0359
Brugia malayi steroid hormone receptor 0.0152 0.2057 0.2057
Schistosoma mansoni zinc finger protein 0.0072 0.0707 0.1247
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0171
Onchocerca volvulus 0.0062 0.054 0.1128
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0607 0.0607
Brugia malayi hypothetical protein 0.0072 0.0707 0.0707
Brugia malayi nuclear receptor NHR-67 0.0072 0.0707 0.0707
Brugia malayi Peroxidasin 0.0051 0.0359 0.0359
Onchocerca volvulus Dual oxidase homolog 0.0051 0.0359 0.0574
Loa Loa (eye worm) hypothetical protein 0.004 0.0171 0.0171
Brugia malayi bZIP transcription factor family protein 0.0246 0.3635 0.3635
Brugia malayi glutaminase DH11.1 0.0296 0.447 0.447
Brugia malayi hypothetical protein 0.0062 0.054 0.054
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0072 0.0707 0.1348
Loa Loa (eye worm) hypothetical protein 0.0047 0.0294 0.0294
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0047 0.0294 0.0294
Onchocerca volvulus Peroxidasin homolog 0.0051 0.0359 0.0574
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.054 0.0928
Brugia malayi Animal haem peroxidase family protein 0.0051 0.0359 0.0359
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0174 0.2425 0.2425
Echinococcus granulosus lamin dm0 0.0055 0.0432 0.0746
Leishmania major carbonic anhydrase-like protein 0.0174 0.2425 1
Brugia malayi tailless protein 0.0072 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.0051 0.0359 0.0359
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0742 0.1436
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0152 0.2057 0.2057
Echinococcus granulosus FTZ F1 alpha 0.0152 0.2057 0.5399
Echinococcus multilocularis lamin dm0 0.0055 0.0432 0.0655
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0742 0.1636
Loa Loa (eye worm) hypothetical protein 0.0235 0.3443 0.3443
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.008 0.0852 0.1711
Brugia malayi laminin alpha chain 0.0047 0.0294 0.0294
Loa Loa (eye worm) nuclear receptor NHR-67 0.0072 0.0707 0.0707

Activities

Activity type Activity value Assay description Source Reference
Delta mean survival time (functional) = 3.9 Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 20 mg/kg dose ChEMBL. 1404226
Delta mean survival time (functional) = 5.7 Antimalarial activity of the compound was measured in mice infected with Plasmodium berghei by subcutaneous administraton at 40 mg/kg ChEMBL. 1404226
Delta mean survival time (functional) = 7.5 Antimalarial activity was measured in mice infected with Plasmodium berghei by subcutaneous administraton of 80 mg/kg ChEMBL. 1404226
Delta mean survival time (functional) = 8.8 Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg dose ChEMBL. 1404226
Delta mean survival time (functional) = 12.8 Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg ChEMBL. 1404226
Delta mean survival time (functional) = 3.9 Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 20 mg/kg dose ChEMBL. 1404226
Delta mean survival time (functional) = 5.7 Antimalarial activity of the compound was measured in mice infected with Plasmodium berghei by subcutaneous administraton at 40 mg/kg ChEMBL. 1404226
Delta mean survival time (functional) = 7.5 Antimalarial activity was measured in mice infected with Plasmodium berghei by subcutaneous administraton of 80 mg/kg ChEMBL. 1404226
Delta mean survival time (functional) = 8.8 Antimalarial activity of the compound was measured against mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg dose ChEMBL. 1404226
Delta mean survival time (functional) = 12.8 Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg ChEMBL. 1404226
No. of cured mice (functional) = 2 Antimalarial activity was measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg ChEMBL. 1404226
No. of cured mice (functional) = 4 Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg ChEMBL. 1404226
No. of cured mice (functional) = 5 Antimalarial activity measured against mice infected with Plasmodium berghei by subcutaneous administraton of 320 mg/kg dose ChEMBL. 1404226
No. of cured mice (functional) = 2 Antimalarial activity was measured in mice infected with Plasmodium berghei by subcutaneous administraton of 160 mg/kg ChEMBL. 1404226
No. of cured mice (functional) = 4 Antimalarial activity measured in mice infected with Plasmodium berghei by subcutaneous administraton of 640 mg/kg ChEMBL. 1404226
No. of cured mice (functional) = 5 Antimalarial activity measured against mice infected with Plasmodium berghei by subcutaneous administraton of 320 mg/kg dose ChEMBL. 1404226

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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