Detailed information for compound 206169

Basic information

Technical information
  • TDR Targets ID: 206169
  • Name: trimethyl-[12-(trimethylazaniumyl)dodecyl]aza nium dibromide
  • MW: 446.347 | Formula: C18H42Br2N2
  • H donors: 0 H acceptors: 0 LogP: 6.95 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[N+](CCCCCCCCCCCC[N+](C)(C)C)(C)C.[Br-].[Br-]
  • InChi: 1S/C18H42N2.2BrH/c1-19(2,3)17-15-13-11-9-7-8-10-12-14-16-18-20(4,5)6;;/h7-18H2,1-6H3;2*1H/q+2;;/p-2
  • InChiKey: KTOBGLRRVLDLEI-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

  • trimethyl-[12-(trimethylammonio)dodecyl]ammonium dibromide
  • trimethyl-(12-trimethylazaniumyldodecyl)azanium dibromide
  • trimethyl-(12-trimethylammoniododecyl)ammonium dibromide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.11101 0.304664 0.304664
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.00939988 0.020678 0.020678
Echinococcus granulosus acetylcholinesterase 0.00818585 0.0172849 0.0131778
Echinococcus granulosus carboxylesterase 5A 0.00818585 0.0172849 0.0131778
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.168942 0.466577 0.464347
Echinococcus multilocularis histone deacetylase 6 0.272019 0.754663 0.753638
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00395794 0.0054685 0.0054685
Leishmania major hypothetical protein, conserved 0.00939988 0.020678 0.020678
Echinococcus multilocularis serine protein kinase ATM 0.00699957 0.0139695 0.00984847
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0382352 0.101269 0.0975129
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0382352 0.101269 0.0975129
Schistosoma mansoni integrin beta subunit 0.15085 0.416013 0.413572
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0129293 0.0305422 0.0264905
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0382352 0.101269 0.0975129
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.00939988 0.020678 0.0165851
Trypanosoma cruzi histone deacetylase, putative 0.272019 0.754663 0.754663
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0129293 0.0305422 0.0264905
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.023176 0.0591805 0.0591805
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0224432 0.0571323 0.0571323
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.17825 0.492593 0.489803
Loa Loa (eye worm) hypothetical protein 0.00800569 0.0167814 0.0167814
Echinococcus granulosus fucosidase alpha L 1 tissue 0.0504952 0.135534 0.131921
Schistosoma mansoni protein kinase 0.00797042 0.0166828 0.0125732
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.031132 0.0814165 0.0814165
Loa Loa (eye worm) phosphatidylinositol kinase 0.00395794 0.0054685 0.0054685
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.492593
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.00395794 0.0054685 0.0054685
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0382352 0.101269 0.0975129
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.17825 0.492593 0.492593
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Loa Loa (eye worm) phosphatidylinositol 3 0.01049 0.0237248 0.0237248
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0672407 0.182335 1
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.00939988 0.020678 0.020678
Trypanosoma brucei Emopamil binding protein, putative 0.0224432 0.0571323 0.0571323
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.023176 0.0591805 0.0591805
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.019267 0.0482552 0.0482552
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.00395794 0.0054685 0.0054685
Loa Loa (eye worm) hypothetical protein 0.0382352 0.101269 0.101269
Giardia lamblia GTOR 0.023176 0.0591805 0.0540073
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.00939988 0.020678 0.0165851
Plasmodium falciparum histone deacetylase 1 0.3598 1 1
Brugia malayi Integrin beta pat-3 precursor 0.262273 0.727426 0.727426
Loa Loa (eye worm) hypothetical protein 0.0411781 0.109494 0.109494
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.17825 0.492593 0.492593
Brugia malayi FAT domain containing protein 0.00349047 0.00416196 0.00416196
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0904426 0.247182 0.247182
Brugia malayi Histone deacetylase family protein 0.272019 0.754663 0.754663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.17825 0.492593 0.490472
Echinococcus granulosus voltage dependent calcium channel 0.0382352 0.101269 0.0975129
Echinococcus multilocularis histone deacetylase 8 0.157184 0.433715 0.431348
Trypanosoma cruzi Emopamil binding protein, putative 0.0224432 0.0571323 0.0571323
Trichomonas vaginalis conserved hypothetical protein 0.00349047 0.00416196 0.00125811
Loa Loa (eye worm) hypothetical protein 0.00704005 0.0140826 0.0140826
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0221607 0.0563427 0.051154
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.051848 0.139315 0.139315
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0408401 0.108549 0.103648
Leishmania major phosphatidylinositol kinase related protein, putative 0.00395794 0.0054685 0.0054685
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.00939988 0.020678 0.0152931
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.01049 0.0237248 0.0237248
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.11101 0.304664 0.304664
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0113332 0.0260815 0.0260815
Schistosoma mansoni histone deacetylase 0.3598 1 1
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.023176 0.0591805 0.0591805
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.17825 0.492593 0.492593
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.3598 1 1
Trypanosoma brucei histone deacetylase, putative 0.272019 0.754663 0.754663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143991 0.0346501 0.0318351
Loa Loa (eye worm) phosphatidylinositol 3 0.00395794 0.0054685 0.0054685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147934 0.0357522 0.0329405
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.031132 0.0814165 0.0763656
Leishmania major hypothetical protein, conserved 0.0224432 0.0571323 0.0571323
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143749 0.0345824 0.0317673
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.031132 0.0814165 0.0775774
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.168942 0.466577 0.464347
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0129293 0.0305422 0.0252116
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.119089 0.327244 0.327244
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.00395794 0.0054685 0.0054685
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.023176 0.0591805 0.0552484
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.00939988 0.020678 0.020678
Loa Loa (eye worm) acetylcholinesterase 1 0.00818585 0.0172849 0.0172849
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.11101 0.304664 0.304664
Schistosoma mansoni serine/threonine protein kinase 0.0231588 0.0591325 0.0552003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Echinococcus multilocularis carboxylesterase 5A 0.00818585 0.0172849 0.0131778
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0224432 0.0571323 0.0571323
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0904426 0.247182 0.247182
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.031132 0.0814165 0.0787379
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0129293 0.0305422 0.0277153
Plasmodium vivax histone deacetylase, putative 0.157184 0.433715 0.430601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0162191 0.0397368 0.0357235
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.119089 0.327244 0.324432
Entamoeba histolytica histone deacetylase, putative 0.3598 1 1
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.17825 0.492593 0.489803
Toxoplasma gondii non-specific serine/threonine protein kinase 0.00744841 0.0152239 0.00980904
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.00939988 0.020678 0.0355158
Schistosoma mansoni histone deacetylase 4 5 0.272019 0.754663 0.753638
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.023176 0.0591805 0.0540073
Loa Loa (eye worm) hypothetical protein 0.0590429 0.159424 0.159424
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.023176 0.0591805 0.0591805
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Schistosoma mansoni histone deacetylase 4 5 0.272019 0.754663 0.753638
Echinococcus multilocularis dual specificity mitogen activated protein 0.00797042 0.0166828 0.0125732
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0382352 0.101269 0.0975129
Echinococcus multilocularis voltage dependent calcium channel 0.0382352 0.101269 0.0975129
Loa Loa (eye worm) phosphatidylinositol 3 0.150739 0.415703 0.415703
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.00797042 0.0166828 0.0166828
Trichomonas vaginalis PIKK family atypical protein kinase 0.00699957 0.0139695 0.0110942
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.119089 0.327244 0.325282
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.492593
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.00797042 0.0166828 0.0166828
Giardia lamblia Hypothetical protein 0.00939988 0.020678 0.0152931
Loa Loa (eye worm) hypothetical protein 0.00704005 0.0140826 0.0140826
Leishmania major hypothetical protein, conserved 0.00395794 0.0054685 0.0054685
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.00395794 0.0054685 0.001312
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00395794 0.0054685 0.0054685
Loa Loa (eye worm) integrin beta-2 0.262273 0.727426 0.727426
Loa Loa (eye worm) phosphatidylinositol 3 0.0271741 0.0703545 0.0703545
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Echinococcus granulosus acetylcholinesterase 0.00818585 0.0172849 0.0131778
Loa Loa (eye worm) hypothetical protein 0.00349047 0.00416196 0.00416196
Brugia malayi Carboxylesterase family protein 0.00818585 0.0172849 0.0172849
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.00939988 0.020678 0.0152931
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Trypanosoma brucei histone deacetylase 3 0.272019 0.754663 0.754663
Entamoeba histolytica protein kinase rad3, putative 0.00699957 0.0139695 0.00854769
Loa Loa (eye worm) histone deacetylase 3 0.3598 1 1
Entamoeba histolytica hypothetical protein 0.00699957 0.0139695 0.00854769
Loa Loa (eye worm) histone deacetylase 1 0.3598 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.023176 0.0591805 0.0552484
Echinococcus granulosus integrin beta 2 0.192028 0.5311 0.52914
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.126402 0.347685 0.347685
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.17825 0.492593 0.489803
Trypanosoma brucei histone deacetylase 2 0.157184 0.433715 0.433715
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.17825 0.492593 0.492593
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0722398 0.196307 0.191888
Loa Loa (eye worm) carboxylesterase 0.00818585 0.0172849 0.0172849
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0129293 0.0305422 0.0305422
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0129293 0.0305422 0.0252116
Echinococcus multilocularis histone deacetylase 7 0.272019 0.754663 0.753638
Schistosoma mansoni histone deacetylase hda2 0.281419 0.780935 0.780019
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.00939988 0.020678 0.020678
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.3598 1 1
Schistosoma mansoni alpha-l-fucosidase 0.0241763 0.0619761 0.0580557
Echinococcus multilocularis Zinc finger, PHD finger 0.0129293 0.0305422 0.0264905
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.00939988 0.020678 0.0152931
Toxoplasma gondii transporter, cation channel family protein 0.00800569 0.0167814 0.0113751
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.01049 0.0237248 0.0196446
Brugia malayi Stress-activated protein kinase jnk-1 0.0231588 0.0591325 0.0591325
Echinococcus multilocularis histone deacetylase 0.272019 0.754663 0.753638
Trypanosoma cruzi histone deacetylase, putative 0.272019 0.754663 0.754663
Echinococcus multilocularis acetylcholinesterase 0.00818585 0.0172849 0.0131778
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0129293 0.0305422 0.0277153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143991 0.0346501 0.0318351
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.17825 0.492593 0.489803
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0129293 0.0305422 0.0264905
Toxoplasma gondii hypothetical protein 0.00704005 0.0140826 0.00866145
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.023176 0.0591805 0.0591805
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0271741 0.0703545 0.0703545
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.00939988 0.020678 0.0165851
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Loa Loa (eye worm) phosphatidylinositol 3 0.023176 0.0591805 0.0591805
Loa Loa (eye worm) hypothetical protein 0.00390902 0.00533178 0.00533178
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.17825 0.492593 0.490472
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.00699957 0.0139695 0.00984847
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.00939988 0.020678 0.0152931
Echinococcus multilocularis histone deacetylase 6 0.272019 0.754663 0.753638
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.051848 0.139315 0.139315
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.00939988 0.020678 0.0165851
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0129293 0.0305422 0.0252116
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.17825 0.492593 0.492593
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.00395794 0.0054685 0.001312
Trypanosoma cruzi histone deacetylase, putative 0.157184 0.433715 0.433715
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.119089 0.327244 0.325282
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.17825 0.492593 0.490472
Brugia malayi Histone deacetylase family protein 0.272019 0.754663 0.754663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.11101 0.304664 0.300841
Leishmania major histone deacetylase, putative 0.3598 1 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.00395794 0.0054685 0.001312
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.01049 0.0237248 0.0196446
Schistosoma mansoni voltage-gated cation channel 0.0382352 0.101269 0.0975129
Plasmodium falciparum histone deacetylase 2 0.272019 0.754663 0.753314
Trypanosoma brucei histone deacetylase 4 0.272019 0.754663 0.754663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0153822 0.0373977 0.0345907
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.00939988 0.020678 0.020678
Brugia malayi histone deacetylase 11 0.157184 0.433715 0.433715
Echinococcus multilocularis histone deacetylase 1 0.3598 1 1
Loa Loa (eye worm) hypothetical protein 0.157184 0.433715 0.433715
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0231588 0.0591325 0.0552003
Brugia malayi Kelch motif family protein 0.0411781 0.109494 0.109494
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0129293 0.0305422 0.0252116
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.023176 0.0591805 0.0591805
Loa Loa (eye worm) calcium channel 0.0382352 0.101269 0.101269
Echinococcus granulosus BRCA1 associated protein 0.00939988 0.020678 0.0165851
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0129293 0.0305422 0.0277153
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.00699957 0.0139695 0.0139695
Trichomonas vaginalis PIKK family atypical protein kinase 0.00699957 0.0139695 0.0110942
Echinococcus granulosus serine:threonine protein kinase SMG1 0.00699957 0.0139695 0.00984847
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0231588 0.0591325 0.0591325
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.17825 0.492593 0.489803
Brugia malayi BRCA1-associated protein 2 containing protein 0.00939988 0.020678 0.020678
Toxoplasma gondii histone deacetylase HDAC2 0.3598 1 1
Leishmania major hypothetical protein, conserved 0.00939988 0.020678 0.020678
Plasmodium vivax histone deacetylase 1, putative 0.3598 1 1
Echinococcus granulosus histone deacetylase 0.272019 0.754663 0.753638
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.00939988 0.020678 0.0165851
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.031132 0.0814165 0.0814165
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.00699957 0.0139695 0.0139695
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0382352 0.101269 0.101269
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.17825 0.492593 0.492593
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.17825 0.492593 0.489803
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0129293 0.0305422 0.0305422
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0129293 0.0305422 0.0305422
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.17825 0.492593 0.492593
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0864846 0.23612 0.231919
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.00395794 0.0054685 0.0054685
Toxoplasma gondii FATC domain-containing protein 0.00699957 0.0139695 0.00854769
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.00395794 0.0054685 0.001312
Trichomonas vaginalis PIKK family atypical protein kinase 0.023176 0.0591805 0.056437
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0590429 0.159424 0.159424
Echinococcus multilocularis acetylcholinesterase 0.00818585 0.0172849 0.0131778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143991 0.0346501 0.0318351
Trichomonas vaginalis PIKK family atypical protein kinase 0.023176 0.0591805 0.056437
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.031132 0.0814165 0.0763656
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.17825 0.492593 0.490472
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.00939988 0.020678 0.0152931
Schistosoma mansoni brca1-associated protein (brap2) 0.00939988 0.020678 0.0165851
Trichomonas vaginalis PIKK family atypical protein kinase 0.0158007 0.0385675 0.035764
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.023176 0.0591805 0.0591805
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0904426 0.247182 0.244987
Trichomonas vaginalis STE family protein kinase 0.00797042 0.0166828 0.0138155
Leishmania major phosphatidylinositol kinase, putative 0.00395794 0.0054685 0.0054685
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.00395794 0.0054685 0.0054685
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.00304162 0.00290751 0.00290751
Trypanosoma cruzi histone deacetylase 1, putative 0.3598 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0904426 0.247182 0.244987
Loa Loa (eye worm) histone deacetylase 0.272019 0.754663 0.754663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0162496 0.0398219 0.0370221
Schistosoma mansoni phosphatidylinositol 4-kinase 0.00395794 0.0054685 0.001312
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Plasmodium vivax hypothetical protein, conserved 0.00939988 0.020678 0.0152931
Plasmodium falciparum histone deacetylase, putative 0.272019 0.754663 0.753314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147934 0.0357522 0.0329405
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0672407 0.182335 1
Echinococcus granulosus histone deacetylase 6 0.272019 0.754663 0.753638
Loa Loa (eye worm) phosphatidylinositol 3 0.00395794 0.0054685 0.0054685
Echinococcus multilocularis integrin beta 2 0.192028 0.5311 0.52914
Loa Loa (eye worm) phosphatidylinositol 3 0.00395794 0.0054685 0.0054685
Trichomonas vaginalis PIKK family atypical protein kinase 0.00786697 0.0163937 0.0135255
Entamoeba histolytica hypothetical protein 0.0722398 0.196307 0.191888
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.11101 0.304664 0.304664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143749 0.0345824 0.0317673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Schistosoma mansoni histone deacetylase 0.3598 1 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.17825 0.492593 0.489803
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0129293 0.0305422 0.0252116
Echinococcus granulosus histone deacetylase 1 0.3598 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0129293 0.0305422 0.0305422
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0232591 0.0594128 0.0594128
Toxoplasma gondii target of rapamycin (TOR), putative 0.0182839 0.0455076 0.0402593
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0591617 0.159756 0.159756
Brugia malayi Histone deacetylase 1 0.3598 1 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.17825 0.492593 0.492593
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.01049 0.0237248 0.0237248
Schistosoma mansoni brca1-associated protein (brap2) 0.00939988 0.020678 0.0165851
Trypanosoma cruzi histone deacetylase, putative 0.272019 0.754663 0.754663
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.00395794 0.0054685 0.001312
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.01049 0.0237248 0.0237248
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.00939988 0.020678 0.0152931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.00939988 0.020678 0.020678
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0591617 0.159756 0.157306
Echinococcus multilocularis voltage dependent calcium channel 0.0382352 0.101269 0.0975129
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.00939988 0.020678 0.0165851
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Echinococcus granulosus voltage dependent calcium channel 0.00800569 0.0167814 0.0126722
Trypanosoma cruzi histone deacetylase 1, putative 0.3598 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0129293 0.0305422 0.0264905
Toxoplasma gondii histone deacetylase HDAC4 0.157184 0.433715 0.430601
Schistosoma mansoni histone deacetylase hda2 0.157184 0.433715 0.431348
Loa Loa (eye worm) alpha-L-fucosidase 0.0241763 0.0619761 0.0619761
Loa Loa (eye worm) phosphatidylinositol 3 0.00395794 0.0054685 0.0054685
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.17825 0.492593 0.490472
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0904426 0.247182 0.244987
Brugia malayi hypothetical protein 0.0411781 0.109494 0.109494
Echinococcus granulosus histone deacetylase 3 0.3598 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.00395794 0.0054685 0.00256846
Brugia malayi Alpha-L-fucosidase family protein 0.0241763 0.0619761 0.0619761
Trichomonas vaginalis brca1-associated protein, putative 0.00939988 0.020678 0.0178223
Toxoplasma gondii histone deacetylase HDAC1 0.272019 0.754663 0.753314
Brugia malayi Carboxylesterase family protein 0.00818585 0.0172849 0.0172849
Trypanosoma brucei target of rapamycin kinase 3, putative 0.019267 0.0482552 0.0482552
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.492593
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0129293 0.0305422 0.0305422
Brugia malayi histone deacetylase 3 (HD3) 0.3598 1 1
Loa Loa (eye worm) histone deacetylase 11 0.157184 0.433715 0.433715
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.00939988 0.020678 0.020678
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Loa Loa (eye worm) hypothetical protein 0.00395794 0.0054685 0.0054685
Plasmodium vivax histone deacetylase 2, putative 0.272019 0.754663 0.753314
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0625317 0.169175 0.166752
Leishmania major phosphatidylinositol 3-kinase, putative 0.0129293 0.0305422 0.0305422
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.00699957 0.0139695 0.00984847
Leishmania major phosphatidylinositol 4-kinase, putative 0.00395794 0.0054685 0.0054685
Echinococcus granulosus histone deacetylase 6 0.281419 0.780935 0.780019
Loa Loa (eye worm) hypothetical protein 0.00699957 0.0139695 0.0139695
Trichomonas vaginalis PIKK family atypical protein kinase 0.023176 0.0591805 0.056437
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00818585 0.0172849 0.0131778
Trypanosoma brucei histone deacetylase 1 0.3598 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.01049 0.0237248 0.0237248
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.00939988 0.020678 0.0165851
Trichomonas vaginalis histone deacetylase, putative 0.3598 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.023176 0.0591805 0.0540073
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.00395794 0.0054685 0.0054685
Leishmania major hypothetical protein, unknown function 0.00395794 0.0054685 0.0054685
Trichomonas vaginalis conserved hypothetical protein 0.00744841 0.0152239 0.0123523
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.3598 1 1
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.00939988 0.020678 0.0152931
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.00939988 0.020678 0.020678
Loa Loa (eye worm) hypothetical protein 0.114835 0.315355 0.315355
Echinococcus multilocularis 0.00395794 0.0054685 0.001312
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.119089 0.327244 0.324432
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0625317 0.169175 0.166752
Loa Loa (eye worm) hypothetical protein 0.00818585 0.0172849 0.0172849
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.00395794 0.0054685 0.001312
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0129293 0.0305422 0.0305422
Mycobacterium ulcerans alpha-L-fucosidase 0.0504952 0.135534 0.275144
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.0504952 0.135534 0.131921
Loa Loa (eye worm) hypothetical protein 0.3598 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.00699957 0.0139695 0.0110942
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.00939988 0.020678 0.020678
Trichomonas vaginalis alpha-L-fucosidase, putative 0.00971519 0.0215593 0.0187061
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.031132 0.0814165 0.0814165
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.17825 0.492593 0.489803
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Schistosoma mansoni fkbp-rapamycin associated protein 0.00699957 0.0139695 0.00984847
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0590429 0.159424 0.155911
Loa Loa (eye worm) hypothetical protein 0.124235 0.341627 0.341627
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.00699957 0.0139695 0.0139695
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00699957 0.0139695 0.0139695
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0904426 0.247182 0.243042
Plasmodium vivax histone deacetylase, putative 0.272019 0.754663 0.753314
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.17825 0.492593 0.5
Leishmania major histone deacetylase, putative 0.272019 0.754663 0.754663
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.00395794 0.0054685 0.0054685
Trichomonas vaginalis STE family protein kinase 0.00797042 0.0166828 0.0138155
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.051848 0.139315 0.139315
Toxoplasma gondii UBA/TS-N domain-containing protein 0.00939988 0.020678 0.0152931
Loa Loa (eye worm) voltage-dependent calcium channel 0.00800569 0.0167814 0.0167814
Trichomonas vaginalis alpha-L-fucosidase, putative 0.00971519 0.0215593 0.0187061
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.00797042 0.0166828 0.0166828
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Brugia malayi histone deacetylase 1 (HD1) 0.3598 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0904426 0.247182 0.247182
Echinococcus granulosus serine protein kinase ATM 0.00699957 0.0139695 0.00984847
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0232591 0.0594128 0.0594128
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.00939988 0.020678 0.020678
Trichomonas vaginalis PIKK family atypical protein kinase 0.0196855 0.0494251 0.0466532
Loa Loa (eye worm) hypothetical protein 0.00304162 0.00290751 0.00290751
Loa Loa (eye worm) hypothetical protein 0.0313997 0.0821646 0.0821646
Trypanosoma cruzi histone deacetylase, putative 0.157184 0.433715 0.433715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147934 0.0357522 0.0329405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Loa Loa (eye worm) hypothetical protein 0.00744841 0.0152239 0.0152239
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0382352 0.101269 0.0975129
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.00939988 0.020678 0.020678
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.00395794 0.0054685 0.00256846
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.17825 0.492593 1
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.00939988 0.020678 0.020678
Toxoplasma gondii histone deacetylase HDAC3 0.3598 1 1
Giardia lamblia Histone deacetylase 0.3598 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.00395794 0.0054685 0.001312
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.00699957 0.0139695 0.00854769
Loa Loa (eye worm) hypothetical protein 0.00818585 0.0172849 0.0172849
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.051848 0.139315 0.139315
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.051848 0.139315 0.139315
Echinococcus granulosus c-Jun N-terminal kinases 0.0231588 0.0591325 0.0552003
Echinococcus granulosus dual specificity mitogen activated protein 0.00797042 0.0166828 0.0125732
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0382352 0.101269 0.0975129
Schistosoma mansoni hypothetical protein 0.00395794 0.0054685 0.001312
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.168942 0.466577 0.464347
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.031132 0.0814165 0.0787379
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.00939988 0.020678 0.0152931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0153822 0.0373977 0.0345907
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.051848 0.139315 0.139315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.00395794 0.0054685 0.001312
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.00797042 0.0166828 0.0166828
Trypanosoma cruzi target of rapamycin kinase 3 0.019267 0.0482552 0.0482552
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.00939988 0.020678 0.0165851
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.00395794 0.0054685 0.001312
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.044329 0.1183 0.113452
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.17825 0.492593 0.492593
Trichomonas vaginalis PIKK family atypical protein kinase 0.00395794 0.0054685 0.00256846
Loa Loa (eye worm) hypothetical protein 0.119089 0.327244 0.327244
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.01049 0.0237248 0.0237248
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00699957 0.0139695 0.0139695
Echinococcus multilocularis sodium channel protein 0.0162191 0.0397368 0.0357235
Toxoplasma gondii histone deacetylase HDAC5 0.157184 0.433715 0.430601
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.00939988 0.020678 0.0152931
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0224432 0.0571323 0.0571323
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.00939988 0.020678 0.0152931
Onchocerca volvulus 0.0224432 0.0571323 0.12064
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0117518 0.0272513 0.0272513
Trichomonas vaginalis PIKK family atypical protein kinase 0.01049 0.0237248 0.020878
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0382352 0.101269 0.0975129
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0382352 0.101269 0.0975129
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0590429 0.159424 0.155911
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.00395794 0.0054685 0.0054685
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0411781 0.109494 0.109494
Trichomonas vaginalis PIKK family atypical protein kinase 0.0192912 0.0483229 0.0455478
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.492593
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0784993 0.213802 0.213802
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.01049 0.0237248 0.0196446
Echinococcus granulosus histone deacetylase 7 0.272019 0.754663 0.753638
Trichomonas vaginalis PIKK family atypical protein kinase 0.00395794 0.0054685 0.00256846
Schistosoma mansoni histone deacetylase 1 2 3 0.157184 0.433715 0.431348
Trichomonas vaginalis PIKK family atypical protein kinase 0.0182839 0.0455076 0.0427243
Echinococcus multilocularis BRCA1 associated protein 0.00939988 0.020678 0.0165851
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.031132 0.0814165 0.0787379
Trichomonas vaginalis BRCA1-associated protein, putative 0.00939988 0.020678 0.0178223
Trichomonas vaginalis STE family protein kinase 0.00797042 0.0166828 0.0138155
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00939988 0.020678 0.0178223
Giardia lamblia Kinase, STE STE20 0.00797042 0.0166828 0.011276
Onchocerca volvulus Histone deacetylase 10 homolog 0.157184 0.433715 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0129293 0.0305422 0.0252116
Trypanosoma cruzi Emopamil binding protein, putative 0.0224432 0.0571323 0.0571323
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0129293 0.0305422 0.0264905
Leishmania major phosphatidylinositol 3-kinase, putative 0.01049 0.0237248 0.0237248
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.17825 0.492593 0.490472
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.17825 0.492593 0.5
Loa Loa (eye worm) histone deacetylase 7A 0.272019 0.754663 0.754663
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.17825 0.492593 0.5
Echinococcus multilocularis histone deacetylase 3 0.3598 1 1
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.119089 0.327244 0.327244
Leishmania major phosphatidylinositol 3-related kinase, putative 0.01049 0.0237248 0.0237248
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.023176 0.0591805 0.0552484
Echinococcus granulosus histone deacetylase 8 0.157184 0.433715 0.431348
Leishmania major histone deacetylase, putative 0.272019 0.754663 0.754663
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.17825 0.492593 0.491114
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.17825 0.492593 0.490472
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.00939988 0.020678 0.020678
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.17825 0.492593 0.490472
Echinococcus granulosus histone deacetylase 6 0.272019 0.754663 0.753638
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.00939988 0.020678 0.0152931
Leishmania major histone deacetylase, putative 0.3598 1 1
Echinococcus multilocularis histone deacetylase 6 0.281419 0.780935 0.780019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143749 0.0345824 0.0317673
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.00797042 0.0166828 0.0166828
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.126402 0.347685 0.347685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143749 0.0345824 0.0317673

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 % Hemolytic activity as a measure of cytotoxicity against human red blood cells at 350 uM ChEMBL. 16420066
Activity (functional) = 0 % Hemolytic activity as a measure of cytotoxicity against human red blood cells at 175 uM ChEMBL. 16420066
Activity (functional) = 0 % Hemolytic activity as a measure of cytotoxicity against human red blood cells at 87.5 uM ChEMBL. 16420066
Activity (functional) = 0 % Hemolytic activity as a measure of cytotoxicity against human red blood cells at 35 uM ChEMBL. 16420066
Activity (functional) = 0 % Hemolytic activity as a measure of cytotoxicity against human red blood cells at 3.5 uM ChEMBL. 16420066
IC50 (functional) = 0 uM Antimicrobial activity against Plasmodium falciparum ChEMBL. 20185316
IC50 (functional) = 0.09 uM In vitro antimalarial activity against Plasmodium falciparum ChEMBL. 10669577
IC50 (functional) = 0.09 uM Inhibitory activity against Plasmodium falciparum ChEMBL. 9357523
IC50 (functional) = 0.09 uM In vitro antimalarial activity against Plasmodium falciparum ChEMBL. 10669577
IC50 (functional) = 0.09 uM Inhibitory activity against Plasmodium falciparum ChEMBL. 9357523
IC50 (functional) = 0.09 uM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by micro dilution assay ChEMBL. 20382538
IC50 (functional) = 0.395 uM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite-specific LDH release after 72 hrs by Malstat assay ChEMBL. 20382538
IC50 (binding) > 250 uM Inhibition of Cryptococccus neoformans H99 PLB1activity ChEMBL. 16420066
IC50 (binding) > 250 uM Inhibition of Cryptococccus neoformans H99 PLB1activity ChEMBL. 16420066
Inhibition (binding) Inhibition of porcine pancreatic PLA2 activity at 25 uM and below ChEMBL. 16420066
Inhibition (binding) Inhibition of porcine pancreatic PLA2 activity at 250 uM ChEMBL. 16420066
Inhibition (binding) 0 Inhibition of porcine pancreatic PLA2 activity at 250 uM ChEMBL. 16420066
Inhibition (binding) 0 Inhibition of porcine pancreatic PLA2 activity at 25 uM and below ChEMBL. 16420066
MIC (functional) = 175 uM Antifungal activity against Cryptococccus neoformans ATCC 90112 ChEMBL. 16420066
MIC (functional) = 175 uM Antifungal activity against Candida albicans ATCC 10231 ChEMBL. 16420066
MIC (functional) = 175 uM Antifungal activity against Cryptococccus neoformans ATCC 90112 ChEMBL. 16420066
MIC (functional) = 175 uM Antifungal activity against Candida albicans ATCC 10231 ChEMBL. 16420066

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 10669577

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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