Detailed information for compound 2069262

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 314.385 | Formula: C16H22N6O
  • H donors: 1 H acceptors: 4 LogP: 0.77 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCC(C1)n1cccn1)CCCNc1ncccn1
  • InChi: 1S/C16H22N6O/c23-15(6-1-7-17-16-18-8-3-9-19-16)21-11-2-5-14(13-21)22-12-4-10-20-22/h3-4,8-10,12,14H,1-2,5-7,11,13H2,(H,17,18,19)
  • InChiKey: DCWKKBAMOMFWMQ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.1359 0.6015 0.8707
Loa Loa (eye worm) hypothetical protein 0.0059 0.0238 0.0339
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0015 0.0038 0.0103
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0019 0.0056 0.0132
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0011 0.0023 0.0605
Trypanosoma cruzi cdc2-related kinase 3 0.0013 0.0031 0.0055
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0019 0.0056 0.0132
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.0056 0.0062
Echinococcus granulosus NDR protein kinase 0.0007 0.0004 0.0000080509
Trichomonas vaginalis 1-phosphatidylinositol phosphodiesterase, putative 0.001 0.0019 0.0204
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0019 0.0056 0.016
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0015 0.0038 0.0405
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0011 0.0023 0.0039
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0025 0.0082 0.6828
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0007 0.0004 0.0000080509
Leishmania major hypothetical protein, conserved 0.0719 0.3168 1
Plasmodium falciparum thioredoxin reductase 0.0011 0.0023 0.1606
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0011 0.0023 0.005
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0313 0.0368
Loa Loa (eye worm) hypothetical protein 0.0082 0.0337 0.0483
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.0164
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0077 0.0184
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0011 0.0023 0.0027
Trichomonas vaginalis AGC family protein kinase 0.0015 0.004 0.0445
Echinococcus granulosus protein kinase c iota type 0.001 0.0018 0.0035
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0019 0.0056 0.0062
Echinococcus multilocularis serine:threonine protein kinase N2 0.0007 0.0004 0.0000080509
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0016 0.0045 0.0103
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0011 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.0164
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0011 0.0023 0.0049
Echinococcus granulosus hyperpolarization activated cyclic 0.0019 0.0056 0.0132
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0077 0.0865
Brugia malayi Cyclic-nucleotide gated cation channel 0.0019 0.0056 0.0052
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0011 0.0023 0.002
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0075 0.0305 1
Echinococcus multilocularis voltage gated potassium channel 0.0019 0.0056 0.0132
Loa Loa (eye worm) ryanodine receptor 0.0339 0.1478 0.2135
Schistosoma mansoni phospholipase C beta 0.0057 0.0228 0.0267
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Schistosoma mansoni voltage-gated ion channel 0.0019 0.0056 0.0062
Echinococcus multilocularis ryanodine receptor 44f 0.0897 0.3958 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0019 0.0056 0.0062
Onchocerca volvulus 0.0072 0.0292 0.3416
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0019 0.0056 0.0132
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Echinococcus granulosus dna polymerase eta 0.0023 0.0077 0.0184
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0051 0.0199 0.0233
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0015 0.0038 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.0164
Loa Loa (eye worm) Plcb4 protein 0.0057 0.0228 0.0325
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0153 0.0653 0.7704
Schistosoma mansoni lamin 0.0033 0.0118 0.0136
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0019 0.0056 0.0052
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0019 0.0056 0.0132
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0019 0.0056 0.0052
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0005 0.0011
Echinococcus granulosus potassium voltage gated channel protein 0.0019 0.0056 0.0132
Onchocerca volvulus 0.0019 0.0056 0.062
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0077 0.0164
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0077 0.0073
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0011 0.0023 0.0811
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0077 0.1892
Echinococcus multilocularis calcium activated potassium channel 0.0019 0.0058 0.0137
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0058 0.0229 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0077 0.0164
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Trypanosoma cruzi CYC2-like cyclin 4, putative 0.0008 0.0007 0.0004
Brugia malayi hypothetical protein 0.001 0.0019 0.0015
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0118 0.0114
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0011 0.0023 0.0057
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0019 0.0056 0.0052
Schistosoma mansoni lamin 0.0033 0.0118 0.0136
Echinococcus multilocularis serine:threonine protein kinase N2 0.0007 0.0004 0.0000080509
Brugia malayi Transient-receptor-potential like protein 0.0019 0.0056 0.0052
Schistosoma mansoni intermediate filament proteins 0.0033 0.0118 0.0136
Echinococcus multilocularis geminin 0.0394 0.1727 0.4356
Trypanosoma cruzi trypanothione reductase, putative 0.0011 0.0023 0.0039
Echinococcus granulosus transient receptor potential cation channel 0.0019 0.0056 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0025 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0021 0.023
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0007 0.0004 0.0000046119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0021 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0008 0.0073
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0004 0.0000037865
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0077 0.0885
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0012 0.0027 0.0034
Echinococcus granulosus shaker cognate 0.0019 0.0056 0.0132
Echinococcus multilocularis transient receptor potential cation channel 0.0019 0.0056 0.0132
Trypanosoma cruzi CYC2-like cyclin 6, putative 0.0008 0.0007 0.0004
Echinococcus multilocularis transfer RNA-Gly 0.0019 0.0056 0.0132
Echinococcus granulosus tar DNA binding protein 0.0076 0.0313 0.0782
Onchocerca volvulus 0.0196 0.0846 1
Trypanosoma cruzi cdc2-related kinase 3 0.0013 0.0031 0.0055
Trichomonas vaginalis AGC family protein kinase 0.0015 0.004 0.0445
Echinococcus multilocularis lipoxygenase domain containing protein 0.001 0.0019 0.0038
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0007 0.0004 0.0000080509
Brugia malayi Cytohesin 3 0.0091 0.0377 0.0374
Echinococcus granulosus short transient receptor potential channel 6 0.0019 0.0056 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Echinococcus multilocularis stromal cell derived factor 2 0.0196 0.0846 0.213
Leishmania major hypothetical protein, conserved 0.001 0.0019 0.0044
Echinococcus granulosus voltage dependent calcium channel 0.0019 0.0056 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.0164
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0019 0.0056 0.0132
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0013 0.0031 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0045 0.0095
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0039 0.0146 0.0312
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0019 0.0056 0.062
Leishmania major CYC2-like cyclin, putative 0.0008 0.0007 0.0006
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0077 0.0087
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0019 0.0056 0.0052
Trichomonas vaginalis CMGC family protein kinase 0.0013 0.0031 0.0341
Echinococcus multilocularis transient receptor potential cation channel 0.0019 0.0056 0.0132
Trichomonas vaginalis AGC family protein kinase 0.0015 0.004 0.0445
Schistosoma mansoni inositol 145-trisphosphate receptor 0.1359 0.6015 0.7149
Echinococcus granulosus two pore calcium channel protein 1 0.0019 0.0056 0.0132
Trichomonas vaginalis CMGC family protein kinase 0.0013 0.0031 0.0341
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.1254 0.5546 0.5545
Onchocerca volvulus 0.001 0.0019 0.0182
Loa Loa (eye worm) hypothetical protein 0.0032 0.0115 0.0161
Loa Loa (eye worm) AGC/AKT protein kinase 0.0015 0.004 0.0052
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0008 0.0011 0.0012
Plasmodium falciparum cyclin, putative 0.0008 0.0007 0.0159
Trypanosoma cruzi inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0082 0.0337 0.0711
Toxoplasma gondii transporter, cation channel family protein 0.0019 0.0056 0.2271
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0056 0.0062
Plasmodium vivax thioredoxin reductase, putative 0.0033 0.0118 1
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0016 0.0045 0.0059
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0007 0.0004 0.0000046119
Trichomonas vaginalis AGC family protein kinase 0.0015 0.004 0.0445
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0153 0.0653 0.7709
Echinococcus granulosus serine:threonine protein kinase N2 0.0007 0.0004 0.0000080509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0028 0.0314
Schistosoma mansoni rab6-interacting 0.001 0.0019 0.0018
Loa Loa (eye worm) MIR domain-containing protein 0.0196 0.0846 0.122
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.0164
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0313 0.0368
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0015 0.0038 0.0103
Echinococcus granulosus microtubule associated protein 2 0.0361 0.1578 0.3981
Plasmodium falciparum thioredoxin reductase 0.0033 0.0118 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0019 0.0056 0.0132
Loa Loa (eye worm) calcium channel 0.0019 0.0056 0.0076
Echinococcus multilocularis musashi 0.0033 0.0118 0.0288
Echinococcus multilocularis sodium channel protein 0.0019 0.0056 0.0132
Echinococcus granulosus protein kinase c epsilon type 0.0012 0.0027 0.0059
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0313 0.0368
Schistosoma mansoni loxhd1 0.001 0.0019 0.0018
Brugia malayi Protein kinase domain containing protein 0.0015 0.004 0.0036
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0011 0.0023 0.5
Echinococcus multilocularis potassium voltage gated channel protein 0.0019 0.0056 0.0132
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0019 0.0056 0.2271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0008 0.0072
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.001 0.0019 0.0015
Echinococcus granulosus hypothetical protein 0.0019 0.0056 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0021 0.023
Echinococcus granulosus sodium leak channel non selective protein 0.0019 0.0056 0.0132
Plasmodium falciparum glutathione reductase 0.0011 0.0023 0.1606
Echinococcus multilocularis sodium leak channel non selective protein 0.0019 0.0056 0.0132
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0011 0.0023 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0023 0.0039
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0005 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0023 0.0039
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0011 0.0023 0.1606
Toxoplasma gondii target of rapamycin (TOR), putative 0.0011 0.0021 0.0719
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0007 0.0004 0.0000080509
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Schistosoma mansoni hypothetical protein 0.0019 0.0056 0.0062
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0019 0.0056 0.0132
Echinococcus multilocularis voltage gated potassium channel 0.0019 0.0056 0.0132
Toxoplasma gondii transporter, cation channel family protein 0.0019 0.0056 0.2271
Echinococcus granulosus voltage dependent calcium channel 0.0019 0.0056 0.0132
Echinococcus multilocularis protein kinase c iota type 0.001 0.0018 0.0035
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0019 0.0056 0.0062
Entamoeba histolytica cell division protein kinase 2, putative 0.0013 0.0031 0.0319
Trypanosoma cruzi CYC2-like cyclin, putative 0.0008 0.0007 0.0004
Echinococcus multilocularis transient receptor potential gamma protein 0.0019 0.0056 0.0132
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0031 0.0032
Entamoeba histolytica protein kinase, putative 0.0016 0.0045 0.0484
Brugia malayi MIR domain containing protein 0.0196 0.0846 0.0843
Giardia lamblia Fructose-bisphosphate aldolase 0.0153 0.0653 1
Onchocerca volvulus 0.001 0.0019 0.018
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Leishmania major phospholipase c-like protein 0.0039 0.0146 0.0445
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0037 0.0136 0.0415
Loa Loa (eye worm) glutathione reductase 0.0033 0.0118 0.0166
Echinococcus granulosus lamin dm0 0.0033 0.0118 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0012 0.0117
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0011 0.0023 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0012 0.0117
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0313 0.0309
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0056 0.0062
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0019 0.0056 0.0132
Entamoeba histolytica PH domain containing protein kinase, putative 0.0008 0.0011 0.0081
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0056 0.0062
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0075 0.0305 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0008 0.001 0.0006
Echinococcus granulosus cyclin dependent kinase 1 0.0013 0.0031 0.0068
Trypanosoma brucei unspecified product 0.0016 0.0045 0.0095
Echinococcus multilocularis cytohesin 1 0.0091 0.0377 0.0944
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0019 0.0056 0.0062
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0007 0.0004 0.0000046119
Loa Loa (eye worm) hypothetical protein 0.156 0.6907 1
Loa Loa (eye worm) voltage-gated calcium channel 0.0019 0.0056 0.0076
Echinococcus multilocularis voltage dependent calcium channel 0.0019 0.0056 0.0132
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0016 0.0045 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0023 0.0039
Leishmania major DNA polymerase eta, putative 0.0023 0.0077 0.0226
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0019 0.0056 0.0132
Schistosoma mansoni voltage-gated cation channel 0.0019 0.0056 0.0062
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0019 0.0056 0.0132
Echinococcus granulosus ryanodine receptor 44f 0.0696 0.3066 0.7742
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0045 0.0505
Trypanosoma brucei chrX additional, unordered contigs 0.0007 0.0005 0.0011
Loa Loa (eye worm) AGC/PKN protein kinase 0.0007 0.0004 0.0000046119
Entamoeba histolytica protein kinase, putative 0.0015 0.004 0.0424
Echinococcus multilocularis ryanodine receptor 44f 0.0696 0.3066 0.7742
Entamoeba histolytica protein kinase, putative 0.0011 0.0023 0.0224
Loa Loa (eye worm) hypothetical protein 0.0094 0.0391 0.0561
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Echinococcus granulosus geminin 0.0394 0.1727 0.4356
Echinococcus granulosus intermediate filament protein 0.0033 0.0118 0.0288
Loa Loa (eye worm) voltage-gated potassium channel 0.0019 0.0056 0.0076
Giardia lamblia Kinase, CMGC CDK 0.0013 0.0031 0.0393
Echinococcus multilocularis transient receptor potential cation channel 0.0019 0.0056 0.0132
Trypanosoma cruzi Protein kinase B 0.0008 0.0011 0.0012
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0019 0.0056 0.0062
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0033 0.0118 0.0288
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0011 0.0023 0.0049
Loa Loa (eye worm) thioredoxin reductase 0.0033 0.0118 0.0166
Brugia malayi intermediate filament protein 0.0033 0.0118 0.0114
Brugia malayi p70 ribosomal S6 kinase beta 0.0011 0.0023 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.0164
Toxoplasma gondii hypothetical protein 0.0019 0.0056 0.2271
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0013 0.0031 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0077 0.0164
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.0056 0.064
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0313 0.0448
Echinococcus granulosus transient receptor potential cation channel 0.0019 0.0056 0.0132
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0019 0.0056 0.0132
Schistosoma mansoni DNA polymerase eta 0.0023 0.0077 0.0087
Echinococcus multilocularis potassium large conductance calcium activated 0.0019 0.0056 0.0132
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0075 0.0305 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0153 0.0653 0.7709
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0077 0.0153
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0059 0.0238 0.0591
Trichomonas vaginalis 1-phosphatidylinositol phosphodiesterase, putative 0.001 0.0019 0.0204
Loa Loa (eye worm) hypothetical protein 0.0035 0.0127 0.0178
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0000046119
Brugia malayi phospholipase C homolog 0.0043 0.0165 0.0161
Schistosoma mansoni hypothetical protein 0.0394 0.1727 0.2049
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.1057 0.4673 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0053
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0019 0.0056 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0153 0.0653 0.7709
Toxoplasma gondii thioredoxin reductase 0.0033 0.0118 0.5054
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0019 0.0056 0.0132
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0029 0.0101 0.0247
Echinococcus granulosus potassium voltage gated channel protein 0.0019 0.0056 0.0132
Echinococcus multilocularis shaker cognate 0.0019 0.0056 0.0132
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0153 0.0653 0.7709
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0019 0.0056 0.0132
Leishmania major DNA polymerase kappa, putative 0.0023 0.0077 0.0226
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0019 0.0056 0.064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0025 0.0269
Echinococcus multilocularis thioredoxin glutathione reductase 0.0033 0.0118 0.0289
Schistosoma mansoni phospholipase C beta 0.001 0.0019 0.0018
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0011 0.0023 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0008 0.0073
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0091 0.0377 0.0444
Giardia lamblia Kinase, CMGC CDK 0.0013 0.0031 0.0393
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.007 0.0283 0.0404
Loa Loa (eye worm) AGC/NDR protein kinase 0.0007 0.0004 0.0000046119
Loa Loa (eye worm) hypothetical protein 0.0016 0.0043 0.0057
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0077 0.0087
Echinococcus granulosus hyperpolarization activated cyclic 0.0019 0.0056 0.0132
Schistosoma mansoni inositol 145-trisphosphate receptor 0.1898 0.8412 1
Brugia malayi Doublecortin family protein 0.001 0.0019 0.0015
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0019 0.0056 0.0052
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0077 0.0164
Schistosoma mansoni transient receptor potential channel 0.0019 0.0056 0.0062
Echinococcus multilocularis conserved hypothetical protein 0.0019 0.0056 0.0132
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0017 0.0173
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0339 0.1478 0.1753
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0031 0.0032
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0019 0.0056 0.0132
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0019 0.0056 0.0132
Echinococcus granulosus Protein kinase C brain isozyme 0.0033 0.0118 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0025 0.0269
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0019 0.0056 0.0132
Loa Loa (eye worm) ion channel NompC 0.0019 0.0056 0.0076
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0019 0.0056 0.0132
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0019 0.0056 0.0132
Echinococcus granulosus lipoxygenase domain containing protein 0.001 0.0019 0.0038
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0015 0.0038 0.007
Brugia malayi Variant SH3 domain containing protein 0.003 0.0109 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0023 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0004 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0004 0.0000037865
Entamoeba histolytica MIR domain protein 0.0196 0.0846 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0019 0.0056 0.0052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0011 0.0023 0.005
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.1057 0.4673 1
Echinococcus granulosus calcium activated potassium channel 0.0019 0.0058 0.0137
Schistosoma mansoni hypothetical protein 0.001 0.0019 0.0018
Brugia malayi voltage-dependent calcium channel 0.0019 0.0056 0.0052
Loa Loa (eye worm) doublecortin family protein 0.001 0.0019 0.0022
Echinococcus multilocularis RUN 0.001 0.0019 0.0038
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0019 0.0056 0.2271
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.0164
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0051 0.0068
Echinococcus granulosus thioredoxin glutathione reductase 0.0033 0.0118 0.0289
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0019 0.0056 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0087
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0013 0.0031 0.0039
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.0164
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0077 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0045 0.0095
Echinococcus granulosus stromal cell derived factor 2 0.0196 0.0846 0.213
Brugia malayi Hr1 repeat family protein 0.0007 0.0004 0.0000031851
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0019 0.0056 0.0132
Schistosoma mansoni atypical protein kinase C 0.001 0.0018 0.0017
Echinococcus granulosus potassium voltage gated channel protein 0.0019 0.0056 0.0132
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Echinococcus granulosus voltage gated hydrogen channel 1 0.0019 0.0056 0.0132
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0016 0.0045 0.0103
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0033 0.0118 0.3366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0008 0.0072
Brugia malayi phospholipase C homolog 0.0016 0.0046 0.0042
Echinococcus granulosus transient receptor potential cation channel 0.0019 0.0056 0.0132
Schistosoma mansoni two-pore calcium channel 0.0019 0.0056 0.0062
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0019 0.0056 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0005 0.0011
Toxoplasma gondii transporter, cation channel family protein 0.0019 0.0056 0.2271
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0019 0.0056 0.0062
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0007 0.0004 0.0008
Trichomonas vaginalis mannosyltransferase 1, putative 0.0196 0.0846 1
Echinococcus granulosus serine/threonine protein kinase 0.0008 0.0011 0.0017
Brugia malayi hypothetical protein 0.001 0.0019 0.0015
Echinococcus multilocularis dna polymerase eta 0.0023 0.0077 0.0184
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0019 0.0056 0.0132
Giardia lamblia DINP protein human, muc B family 0.0023 0.0077 0.1103
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0011 0.0023 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0038 0.0034
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0045 0.0505
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0007 0.0004 0.0000080509
Echinococcus multilocularis lamin dm0 0.0033 0.0118 0.0288
Trypanosoma brucei rac serine-threonine kinase, putative 0.0015 0.004 0.0085
Schistosoma mansoni 60S ribosomal protein L21 0.0019 0.0056 0.0062
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0118 0.0165
Echinococcus multilocularis potassium voltage gated channel protein 0.0019 0.0056 0.0132
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0165
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0153 0.0653 0.7709
Echinococcus multilocularis Polycystic kidney disease protein 0.001 0.0019 0.0038
Echinococcus granulosus potassium large conductance calcium activated 0.0019 0.0056 0.0132
Onchocerca volvulus 0.0033 0.0118 0.1354
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0118 0.0242
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0013 0.0031 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0004 0.0023
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Leishmania major trypanothione reductase 0.0033 0.0118 0.0357
Loa Loa (eye worm) hypothetical protein 0.0082 0.0337 0.0483
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0153 0.0653 0.7709
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.007 0.0283 0.0279
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0019 0.0056 0.0062
Trypanosoma brucei cdc2-related kinase 3 0.0013 0.0031 0.0066
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0086 0.0354 0.0758
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Plasmodium falciparum LCCL domain-containing protein 0.001 0.0019 0.1213
Entamoeba histolytica cell division protein kinase 2, putative 0.0013 0.0031 0.0319
Loa Loa (eye worm) voltage-gated potassium channel 0.0019 0.0056 0.0076
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0057 0.0228 0.0224
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0019 0.0056 0.0132
Echinococcus multilocularis potassium voltage gated channel protein 0.0019 0.0056 0.0132
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0019 0.0056 0.0132
Brugia malayi ion channel NompC 0.0019 0.0056 0.0052
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0019 0.0056 0.012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.0056 0.0062
Trypanosoma brucei glycosylphosphatidylinositol-specific phospholipase C 0.001 0.0019 0.0041
Trichomonas vaginalis glutathione reductase, putative 0.0011 0.0023 0.0254
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0015 0.0038 0.0081
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.001 0.0019 0.0022
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0019 0.0056 0.0062
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0019 0.0056 0.0076
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0015 0.0038 0.007
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0019 0.0056 0.0132
Trypanosoma cruzi cdc2-related kinase 1 0.0013 0.0031 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0077 0.0153
Echinococcus granulosus short transient receptor potential channel 6 0.0019 0.0056 0.0132
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0038 0.0049
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0019 0.0056 0.062
Brugia malayi hypothetical protein 0.0019 0.0056 0.0052
Brugia malayi cell division control protein 2 homolog 0.0013 0.0031 0.0027
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0077 0.0226
Loa Loa (eye worm) ryanodine receptor 0.0019 0.0056 0.0076
Brugia malayi phosphoinositide-dependent protein kinase I 0.0016 0.0045 0.0041
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0077 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0025 0.0269
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0059 0.0238 0.0591
Trypanosoma brucei DNA damage repair protein, putative 0.0007 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.0114
Echinococcus granulosus lipoxygenase domain containing protein 0.001 0.0019 0.0038
Giardia lamblia GTOR 0.0015 0.0038 0.0505
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0313 0.0448
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0015 0.0038 0.0086
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0196 0.0846 0.1002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0015 0.0038 0.0405
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0004 0.0000037865
Echinococcus granulosus transient receptor potential cation channel 0.0019 0.0056 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0023 0.0075 0.0103
Loa Loa (eye worm) hypothetical protein 0.0082 0.0337 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0038 0.0426
Onchocerca volvulus 0.0102 0.0429 0.5042
Schistosoma mansoni voltage-dependent calcium channel 0.0019 0.0056 0.0062
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0011 0.0023 0.0057
Loa Loa (eye worm) hypothetical protein 0.0024 0.0078 0.0107
Trichomonas vaginalis AGC family protein kinase 0.0015 0.004 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0015 0.0157
Trypanosoma brucei unspecified product 0.0023 0.0077 0.0164
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0004 0.0000037865
Brugia malayi RNA binding protein 0.0076 0.0313 0.0309
Schistosoma mansoni transient receptor potential channel 0.0019 0.0056 0.0062
Echinococcus granulosus transient receptor potential gamma protein 0.0019 0.0056 0.0132
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0019 0.0056 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0007 0.0005 0.0011
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0021 0.0222
Trichomonas vaginalis AGC family protein kinase 0.0015 0.004 0.0445
Echinococcus multilocularis lipoxygenase domain containing protein 0.001 0.0019 0.0038
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Schistosoma mansoni vesicular amine transporter 0.0019 0.0056 0.0062
Echinococcus granulosus potassium voltage gated channel protein 0.0019 0.0056 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0038 0.0426
Brugia malayi olfactory channel protein osm-9 0.0019 0.0056 0.0052
Schistosoma mansoni calcium-activated potassium channel 0.0019 0.0056 0.0062
Schistosoma mansoni lipoxygenase 0.0029 0.0101 0.0116
Loa Loa (eye worm) hypothetical protein 0.0897 0.3958 0.5728
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0012 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0021 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0045 0.0095
Echinococcus granulosus dna polymerase kappa 0.0023 0.0077 0.0184
Schistosoma mansoni serine/threonine kinase 0.0007 0.0004 0.0000037865
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0019 0.0056 0.0132
Trichomonas vaginalis AGC family protein kinase 0.0015 0.004 0.0445
Onchocerca volvulus 0.001 0.0019 0.018
Echinococcus granulosus voltage gated potassium channel 0.0019 0.0056 0.0132
Echinococcus multilocularis cyclin dependent kinase 5 0.0013 0.0031 0.0068
Schistosoma mansoni serine/threonine-protein kinase 0.0008 0.0011 0.0008
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0025 0.0082 0.0079
Schistosoma mansoni lipoxygenase 0.001 0.0019 0.0018
Giardia lamblia NADH oxidase lateral transfer candidate 0.0011 0.0023 0.028
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0008 0.0007 0.008
Echinococcus multilocularis transient receptor potential cation channel 0.0019 0.0056 0.0132
Onchocerca volvulus 0.0033 0.0118 0.1354
Schistosoma mansoni hypothetical protein 0.0394 0.1727 0.2049
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0022
Echinococcus multilocularis hyperpolarization activated cyclic 0.0019 0.0056 0.0132
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0004 0.0023
Echinococcus multilocularis hyperpolarization activated cyclic 0.0019 0.0056 0.0132
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0011 0.0023 0.0057
Schistosoma mansoni serine/threonine-protein kinase 0.0008 0.0011 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0153 0.0653 0.7709
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0007 0.0004 0.0000080509
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0019 0.0056 0.0052
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0077 0.1892
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0077 0.0885
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0019 0.0056 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Echinococcus multilocularis two pore calcium channel protein 2 0.0019 0.0056 0.0132
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Schistosoma mansoni transient receptor potential channel 0.0019 0.0056 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0008 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0045 0.0505
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0039 0.0146 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0038 0.0426
Plasmodium vivax glutathione reductase, putative 0.0033 0.0118 1
Toxoplasma gondii NADPH-glutathione reductase 0.0011 0.0023 0.0811
Brugia malayi Protein kinase domain containing protein 0.0013 0.0031 0.0027
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0013 0.0031 0.1139
Trichomonas vaginalis mercuric reductase, putative 0.0011 0.0023 0.0254
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0027 0.0028
Echinococcus granulosus RUN 0.001 0.0019 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0008 0.0072
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0019 0.0056 0.0132
Loa Loa (eye worm) hypothetical protein 0.1537 0.6805 0.9851
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0019 0.0056 0.0132
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0153 0.0653 0.7709
Loa Loa (eye worm) RNA binding protein 0.0076 0.0313 0.0448
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Echinococcus multilocularis two pore calcium channel protein 1 0.0019 0.0056 0.0132
Treponema pallidum fructose-bisphosphate aldolase 0.0153 0.0653 1
Echinococcus granulosus cytohesin 1 0.0091 0.0377 0.0944
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.0056 0.0132
Echinococcus multilocularis transient receptor potential cation channel 0.0019 0.0056 0.0132
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0313 0.0782
Echinococcus granulosus ryanodine receptor 44f 0.0897 0.3958 1
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Trypanosoma brucei unspecified product 0.0016 0.0045 0.0095
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0012 0.0025 0.0062
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0077 0.0184
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0011 0.0023 0.0039
Plasmodium vivax cyclin, putative 0.0008 0.0007 0.0159
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0036
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0043 0.0099
Echinococcus multilocularis cyclin dependent kinase 0.0013 0.0031 0.0068
Echinococcus multilocularis cyclin dependent kinase 1 0.0013 0.0031 0.0068
Brugia malayi cation channel family protein 0.0019 0.0056 0.0052
Echinococcus multilocularis cyclin dependent kinase 1 0.0013 0.0031 0.0068
Leishmania major hypothetical protein, unknown function 0.0019 0.0056 0.016
Echinococcus multilocularis lamin 0.0033 0.0118 0.0288
Echinococcus multilocularis potassium voltage gated channel protein 0.0019 0.0056 0.0132
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.002 0.0064 0.0152
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0019 0.0056 0.0132
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0008 0.001 0.0006
Echinococcus multilocularis short transient receptor potential channel 6 0.0019 0.0056 0.0132
Brugia malayi protein kinase C II. 0.0012 0.0027 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0313 0.0368
Toxoplasma gondii AGC kinase 0.0011 0.0023 0.0781
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0077 0.0153
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0019 0.0056 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0007 0.006
Trypanosoma brucei cyclin 2 0.0008 0.0007 0.0015
Schistosoma mansoni ryanodine receptor related 0.1254 0.5546 0.6591
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0019 0.0056 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0021 0.023
Onchocerca volvulus 0.0035 0.0127 0.1459
Echinococcus granulosus sodium channel protein 0.0019 0.0056 0.0132
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0011 0.0023 0.1606
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0021 0.023
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0043 0.0099
Schistosoma mansoni transient receptor potential channel 4 0.0019 0.0056 0.0062
Trichomonas vaginalis CMGC family protein kinase 0.0013 0.0031 0.0341
Entamoeba histolytica PH domain containing protein kinase, putative 0.0008 0.0011 0.0081
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0025 0.0082 0.0244
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0118 0.0165
Brugia malayi glutathione reductase 0.0033 0.0118 0.0114
Echinococcus multilocularis rac serine:threonine kinase 0.0008 0.0011 0.0017
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0019 0.0056 0.0062
Leishmania major inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0082 0.0337 0.105
Trypanosoma cruzi inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0082 0.0337 0.0711
Echinococcus multilocularis RNA directed DNA polymerase 0.002 0.0064 0.0152
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0077 0.0153
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0313 0.0368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0025 0.0269
Echinococcus granulosus Polycystic kidney disease protein 0.001 0.0019 0.0038
Echinococcus granulosus protein kinase C gamma type 0.0029 0.0104 0.0253
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0015 0.0038 0.0081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0023 0.0039
Brugia malayi Protein kinase domain containing protein 0.0016 0.0045 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0011 0.0113
Plasmodium vivax protein kinase Crk2 0.0013 0.0031 0.2253
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0019 0.0056 0.0132
Trypanosoma cruzi cdc2-related kinase 1 0.0013 0.0031 0.0055
Echinococcus granulosus cyclin dependent kinase 0.0013 0.0031 0.0068
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0011 0.0023 0.1606
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0077 0.0153
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0011 0.0023 0.0605
Toxoplasma gondii hypothetical protein 0.0019 0.0056 0.2271
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.0164
Trypanosoma brucei cdc2-related kinase 1 0.0013 0.0031 0.0066
Schistosoma mansoni microtubule-associated protein tau 0.0361 0.1578 0.1872
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0077 0.2382
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0015 0.0038 0.0086
Echinococcus granulosus transient receptor potential cation channel 0.0019 0.0056 0.0132
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0019 0.0056 0.0052
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0019 0.0056 0.0132
Echinococcus granulosus two pore calcium channel protein 2 0.0019 0.0056 0.0132
Trypanosoma brucei CYC2-like cyclin, putative 0.0008 0.0007 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0118 0.0136
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Plasmodium vivax phospholipase C-like, putative 0.0025 0.0082 0.6828
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0013 0.0031 0.008
Brugia malayi TAR-binding protein 0.0076 0.0313 0.0309
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Brugia malayi polk-prov protein 0.0007 0.0005 0.0001
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0019 0.0056 0.0109
Brugia malayi Protein kinase domain containing protein 0.0007 0.0004 0.0000031851
Trypanosoma brucei trypanothione reductase 0.0033 0.0118 0.0253
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0077 0.0164
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0019 0.0056 0.0132
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0012 0.0025 0.0053
Entamoeba histolytica protein kinase, putative 0.0015 0.004 0.0424
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0011 0.0023 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0045 0.0049
Plasmodium falciparum protein kinase 5 0.0013 0.0031 0.2253
Trypanosoma cruzi target of rapamycin kinase 3 0.0012 0.0025 0.0042
Echinococcus multilocularis microtubule associated protein 2 0.0361 0.1578 0.3981
Schistosoma mansoni voltage-gated potassium channel 0.0019 0.0056 0.0062
Echinococcus granulosus potassium voltage gated channel protein 0.0019 0.0056 0.0132
Plasmodium vivax multidomain scavenger receptor, putative 0.001 0.0019 0.1213
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0019 0.0056 0.0052
Loa Loa (eye worm) hypothetical protein 0.0007 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0077 0.0106
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0077 0.0073
Echinococcus multilocularis voltage dependent calcium channel 0.0019 0.0056 0.0132
Loa Loa (eye worm) hypothetical protein 0.001 0.0019 0.0022
Schistosoma mansoni rab6-interacting 0.001 0.0019 0.0018
Toxoplasma gondii cyclin2 related protein 0.0008 0.0007 0.008
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0051 0.0047
Loa Loa (eye worm) variant SH3 domain-containing protein 0.003 0.0109 0.0152
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0011 0.0023 0.0057
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0019 0.0056 0.0132
Echinococcus granulosus lamin 0.0033 0.0118 0.0288
Echinococcus granulosus RNA directed DNA polymerase 0.002 0.0064 0.0152
Loa Loa (eye worm) cytohesin 3 0.0091 0.0377 0.0541
Schistosoma mansoni polycystin 1-related 0.001 0.0019 0.0018
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0077 0.2382
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0019 0.0056 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0011 0.0113
Echinococcus granulosus TRP transient receptor potential channel 0.0019 0.0056 0.0132
Echinococcus granulosus transient receptor potential cation channel 0.0019 0.0056 0.0132
Loa Loa (eye worm) voltage-dependent calcium channel 0.0019 0.0056 0.0076
Brugia malayi Protein kinase domain containing protein 0.0007 0.0004 0.0000031851
Brugia malayi Protein kinase c protein 2 0.0026 0.0089 0.0085
Echinococcus granulosus cyclin dependent kinase 5 0.0013 0.0031 0.0068
Brugia malayi Thioredoxin reductase 0.0033 0.0118 0.0114
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0029 0.0101 0.0247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0021 0.023
Echinococcus multilocularis transient receptor potential cation channel 0.0019 0.0056 0.0132
Plasmodium falciparum glutathione reductase 0.0033 0.0118 1
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0005 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0007 0.0005 0.0011
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0019 0.0056 0.0052
Echinococcus granulosus voltage gated potassium channel 0.0019 0.0056 0.0132
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0013 0.0031 0.0068
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0019 0.0056 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0008 0.0073
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.0023 0.0039
Echinococcus multilocularis protein kinase c epsilon type 0.0012 0.0027 0.0059
Echinococcus multilocularis serine threonine protein kinase 0.0029 0.0104 0.0253
Echinococcus multilocularis short transient receptor potential channel 6 0.0019 0.0056 0.0132
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.0053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0076
Echinococcus multilocularis serine:threonine protein kinase 38 0.0007 0.0004 0.0000080509
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0153 0.0653 0.7704
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0007 0.0004 0.0000080509
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0043 0.0165 0.0191
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0011 0.0023 0.1606
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0019 0.0056 0.0052

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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