Detailed information for compound 207071

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 305.255 | Formula: C15H10F3N3O
  • H donors: 1 H acceptors: 2 LogP: 3.5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(Oc1ccc(cc1)c1c[nH]c(n1)c1cccnc1)(F)F
  • InChi: 1S/C15H10F3N3O/c16-15(17,18)22-12-5-3-10(4-6-12)13-9-20-14(21-13)11-2-1-7-19-8-11/h1-9H,(H,20,21)
  • InChiKey: QFUHQTVKGNOKSY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide Y receptor Y5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0734 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0204 0.1773
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0007 0.0008 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0039 0.0075
Echinococcus multilocularis sphingosine kinase 1 0.0297 0.3715 0.3715
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0734 1
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0012 0.0061 0.006
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0947 0.3028
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0348 0.1114
Entamoeba histolytica hypothetical protein 0.0034 0.0348 0.0918
Loa Loa (eye worm) hypothetical protein 0.0014 0.0092 0.0244
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0101
Echinococcus granulosus Protein kinase C brain isozyme 0.0013 0.0083 0.0164
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0669 0.5626
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0039 0.0075
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0388 0.1241
Echinococcus granulosus lamin 0.0026 0.0249 0.0495
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0039 0.0416 0.1328
Brugia malayi diacylglycerol kinase 0.0016 0.0124 0.0393
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0164 0.0438
Brugia malayi p70 ribosomal S6 kinase beta 0.0007 0.0008 0.002
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0204 0.2344
Chlamydia trachomatis endonuclease IV 0.0074 0.0867 1
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0039 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0069 0.0182
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0039 0.0075
Schistosoma mansoni diacylglycerol kinase theta 0.0016 0.0124 0.0245
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0077 0.0901 0.2422
Schistosoma mansoni lipoxygenase 0.0099 0.1184 0.2366
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0101
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0204 0.0546
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0734 0.1466
Loa Loa (eye worm) hypothetical protein 0.0019 0.0153 0.0409
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0388 0.1041
Schistosoma mansoni lamin 0.0026 0.0249 0.0495
Schistosoma mansoni hypothetical protein 0.0122 0.1479 0.2956
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0039 0.0409 0.0407
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0204 0.0546
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0416 0.1102
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0039 0.0416 0.3498
Schistosoma mansoni cpg binding protein 0.003 0.0291 0.0579
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.1187 0.2372
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0039 0.0038
Schistosoma mansoni rab6-interacting 0.0038 0.0404 0.0805
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0669 0.1335
Schistosoma mansoni thyroid hormone receptor 0.0132 0.1605 0.3207
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0039 0.0038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0669 0.1797
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0039 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0416 0.083
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0083 0.0164
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0061 0.0196
Brugia malayi Protein kinase domain containing protein 0.0007 0.0008 0.002
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0348 0.0934
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0204 0.1773
Onchocerca volvulus 0.0033 0.0332 0.1478
Echinococcus multilocularis serine:threonine protein kinase N2 0.0007 0.0008 0.0006
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0019 0.0153 0.0486
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0164 0.0438
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0039 0.0409 0.0814
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0039 0.0416 0.5659
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0022 0.0067
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.1479 0.2956
Leishmania major protein kinase A catalytic subunit isoform 1 0.0039 0.0416 0.5659
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0734 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0251 0.3126 1
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0061 0.0196
Echinococcus multilocularis cpg binding protein 0.003 0.0291 0.029
Echinococcus multilocularis geminin 0.0165 0.2021 0.202
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0204 0.5
Mycobacterium tuberculosis Diacylglycerol kinase 0.0012 0.0061 0.0162
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0061 0.0819
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0066 0.0763 0.1523
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0039 0.0121
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0002 0.0001
Leishmania major protein kinase A catalytic subunit isoform 2 0.0039 0.0416 0.5659
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.1479 0.1478
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2021 0.6466
Onchocerca volvulus 0.0012 0.0061 0.0113
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0033 0.0332 0.1058
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0039 0.0075
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2135 0.6829
Plasmodium falciparum LCCL domain-containing protein 0.0038 0.0404 0.4252
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0669 0.1335
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0061 0.0196
Loa Loa (eye worm) hypothetical protein 0.0038 0.0404 0.1084
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0947 0.0946
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0039 0.0121
Echinococcus multilocularis Polycystic kidney disease protein 0.0038 0.0404 0.0403
Mycobacterium ulcerans hypothetical protein 0.0297 0.3715 1
Echinococcus granulosus RUN 0.0038 0.0404 0.0805
Plasmodium vivax multidomain scavenger receptor, putative 0.0038 0.0404 0.4252
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0039 0.0038
Echinococcus multilocularis lamin 0.0026 0.0249 0.0247
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0348 0.3561
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3126 1
Brugia malayi steroid hormone receptor 0.001 0.0039 0.0121
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0388 0.4053
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0039 0.0121
Mycobacterium ulcerans diacylglycerol kinase 0.0012 0.0061 0.0162
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0037 0.0388 0.5272
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0039 0.0416 0.5659
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0039 0.0121
Loa Loa (eye worm) ceramide kinase 0.0012 0.0061 0.0162
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0101
Loa Loa (eye worm) hypothetical protein 0.0014 0.0092 0.0244
Loa Loa (eye worm) hypothetical protein 0.0066 0.0763 0.205
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0008 0.0024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0092 0.0244
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0039 0.0416 0.0415
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0083 0.0164
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0024 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0039 0.0121
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0039 0.0121
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0039 0.0101
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0039 0.0121
Schistosoma mansoni thyroid hormone receptor 0.0132 0.1605 0.3207
Toxoplasma gondii endonuclease IV APN 0.0074 0.0867 0.7296
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0013 0.0083 0.0082
Echinococcus granulosus FTZ F1 alpha 0.001 0.0039 0.0075
Echinococcus granulosus Diacylglycerol kinase zeta 0.0012 0.0061 0.012
Brugia malayi hypothetical protein 0.0014 0.0092 0.029
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0249 0.0666
Brugia malayi Protein kinase domain containing protein 0.0007 0.0008 0.002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0671 0.1339
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.0867 1
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0039 0.0416 0.083
Mycobacterium leprae conserved hypothetical protein 0.002 0.0164 0.188
Giardia lamblia Kinase, AGC PKA 0.0039 0.0416 0.5
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0013 0.0083 0.0221
Schistosoma mansoni cpg binding protein 0.0028 0.0271 0.0538
Leishmania major protein kinase A catalytic subunit 0.0039 0.0416 0.5659
Brugia malayi nuclear hormone receptor 0.001 0.0039 0.0121
Loa Loa (eye worm) hypothetical protein 0.0012 0.0061 0.0162
Loa Loa (eye worm) hypothetical protein 0.0038 0.0404 0.1084
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3126 1
Mycobacterium ulcerans endonuclease IV 0.0074 0.0867 0.233
Loa Loa (eye worm) hypothetical protein 0.0013 0.0075 0.0199
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0204 0.171
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0007 0.0008 0.0017
Echinococcus granulosus protein kinase c epsilon type 0.0013 0.0083 0.0164
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0039 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0061 0.0196
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0012 0.0061 0.0162
Echinococcus granulosus protein kinase C gamma type 0.0008 0.0021 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0039 0.0121
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0037 0.0388 0.0773
Echinococcus multilocularis ceramide kinase 0.0012 0.0061 0.006
Entamoeba histolytica hypothetical protein 0.0023 0.0204 0.053
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0037 0.0388 0.0387
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.01 0.1187 0.1186
Loa Loa (eye worm) hypothetical protein 0.0019 0.0153 0.0409
Schistosoma mansoni loxhd1 0.0038 0.0404 0.0805
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.0867 1
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0008 0.0024
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0039 0.0416 0.0415
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0101
Brugia malayi diacylglycerol kinase 0.0016 0.0124 0.0393
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0404 0.0403
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0093 0.0293
Schistosoma mansoni hypothetical protein 0.0398 0.5001 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0007 0.0008 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0008 0.0013
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0074 0.0867 1
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0061 0.0819
Brugia malayi beta-NAC-like protein 0.0034 0.0348 0.111
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0039 0.0121
Schistosoma mansoni transcription factor btf3 0.0034 0.0348 0.0694
Onchocerca volvulus 0.0033 0.0332 0.1478
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0734 0.196
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0388 0.1241
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0093 0.0247
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0007 0.0008 0.0013
Schistosoma mansoni sphingosine kinase A B 0.0297 0.3715 0.7429
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0039 0.0075
Onchocerca volvulus Ceramide kinase 1 homolog 0.0012 0.0061 0.0113
Brugia malayi LBP/BPI 0.0014 0.0092 0.029
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0101
Toxoplasma gondii AGC kinase 0.0039 0.0416 0.3498
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0075 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0039 0.0101
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0101
Toxoplasma gondii AGC kinase 0.0039 0.0416 0.3498
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0008 0.0024
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0061 0.0196
Brugia malayi CXXC zinc finger family protein 0.0028 0.0271 0.0862
Onchocerca volvulus 0.0033 0.0332 0.1478
Echinococcus granulosus intermediate filament protein 0.0026 0.0249 0.0495
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0024 0.0061
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0008 0.0024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0243 0.065
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0012 0.0061 0.012
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0404 0.0403
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0014 0.0094 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0008 0.0013
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0061 0.0145
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2021 0.6466
Brugia malayi nuclear receptor NHR-88 0.001 0.0039 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0039 0.0121
Leishmania major hypothetical protein, conserved 0.0012 0.0061 0.0819
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0033 0.0332 0.1058
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0348 0.2925
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0251 0.3126 0.8412
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0249 0.0792
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0734 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0002 0.0001
Brugia malayi hypothetical protein 0.0019 0.0153 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0039 0.0121
Loa Loa (eye worm) hypothetical protein 0.0019 0.0153 0.0409
Trypanosoma brucei diacylglycerol kinase, putative 0.0012 0.0061 0.0819
Echinococcus granulosus ceramide kinase 0.0012 0.0061 0.012
Mycobacterium tuberculosis Conserved protein 0.0297 0.3715 1
Leishmania major hypothetical protein, conserved 0.0012 0.0061 0.0819
Echinococcus granulosus lamin dm0 0.0026 0.0249 0.0495
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0039 0.0121
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0039 0.0075
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0007 0.0008 0.0017
Trypanosoma cruzi diacylglycerol kinase, putative 0.0012 0.0061 0.0819
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0061 0.0196
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0039 0.0416 0.4405
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0007 0.0008 0.0006
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0039 0.0416 0.5659
Brugia malayi hypothetical protein 0.0038 0.0404 0.1288
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0002 0.0001
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0019 0.0153 0.0486
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0037 0.0388 0.1237
Loa Loa (eye worm) hypothetical protein 0.0014 0.0092 0.0244
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3126 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0007 0.0008 0.0017
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0007 0.0008 0.0013
Leishmania major diacylglycerol kinase, putative 0.0012 0.0061 0.0819
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0066 0.0763 0.1523
Brugia malayi Diacylglycerol kinase protein 2 0.0012 0.0061 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0348 0.1114
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.059 0.4964
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0002 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0008 0.0024
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0164 0.0631
Brugia malayi intermediate filament protein 0.0026 0.0249 0.0792
Entamoeba histolytica diacylglycerol kinase, putative 0.0012 0.0061 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0039 0.0101
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3126 1
Toxoplasma gondii melibiase subfamily protein 0.01 0.1187 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0039 0.0101
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0388 0.4053
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.2021 1
Brugia malayi hypothetical protein 0.0012 0.0061 0.0192
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0012 0.0061 0.012
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0404 0.0805
Echinococcus multilocularis Glycoside hydrolase, family 27 0.01 0.1187 0.1186
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0669 0.1797
Trichomonas vaginalis bmru protein, putative 0.0012 0.0061 0.0196
Loa Loa (eye worm) AGC/PKN protein kinase 0.0007 0.0008 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3126 1
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0389 0.0775
Loa Loa (eye worm) doublecortin family protein 0.0038 0.0404 0.1084
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2021 0.6466
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0037 0.0388 0.1237
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0074 0.0867 0.233
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0204 0.171
Loa Loa (eye worm) AGC/PKA protein kinase 0.0039 0.0416 0.1117
Onchocerca volvulus 0.0081 0.0947 0.4584
Onchocerca volvulus 0.0038 0.0404 0.184
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0019 0.0153 0.0409
Schistosoma mansoni atypical protein kinase C 0.0084 0.0988 0.1973
Entamoeba histolytica diacylglycerol kinase, putative 0.0016 0.0124 0.0314
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0039 0.0075
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0075 0.0148
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0039 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0416 0.083
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.5001 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0069 0.0182
Schistosoma mansoni cpg binding protein 0.003 0.0291 0.0579
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0204 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0039 0.0075
Echinococcus multilocularis Diacylglycerol kinase theta 0.0016 0.0124 0.0123
Brugia malayi Hr1 repeat family protein 0.0007 0.0008 0.002
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0012 0.0061 0.0506
Loa Loa (eye worm) hypothetical protein 0.0081 0.0947 0.2547
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.1605 0.1604
Onchocerca volvulus 0.0028 0.0271 0.1168
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0039 0.0416 0.0415
Trichomonas vaginalis glucosylceramidase, putative 0.0251 0.3126 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0039 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0039 0.0121
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0008 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0024 0.0022
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0039 0.0416 0.5659
Onchocerca volvulus 0.0033 0.0332 0.1478
Loa Loa (eye worm) hypothetical protein 0.0026 0.0249 0.0666
Entamoeba histolytica diacylglycerol kinase, putative 0.0016 0.0124 0.0314
Loa Loa (eye worm) diacylglycerol kinase 2 0.0012 0.0061 0.0162
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0007 0.0008 0.0017
Onchocerca volvulus 0.0019 0.0153 0.0577
Schistosoma mansoni rab6-interacting 0.0038 0.0404 0.0805
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2135 0.6829
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0061 0.0196
Leishmania major sphingosine kinase A, B, putative 0.0012 0.0061 0.0819
Echinococcus granulosus transcription factor btf3 0.0034 0.0348 0.0694
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0734 0.2346
Leishmania major basic transcription factor 3a, putative 0.0034 0.0348 0.4732
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0168 0.2067 0.4132
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0669 0.0667
Onchocerca volvulus 0.0033 0.0332 0.1478
Toxoplasma gondii diacylglycerol kinase, putative 0.0016 0.0124 0.1035
Onchocerca volvulus 0.0026 0.0249 0.1058
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0416 0.1331
Onchocerca volvulus 0.0038 0.0404 0.184
Brugia malayi Melibiase family protein 0.0066 0.0763 0.2438
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0388 0.5272
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0037 0.0388 0.5272
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0389 0.0387
Echinococcus granulosus sphingosine kinase 1 0.0297 0.3715 0.7429
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0039 0.0416 0.5659
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0404 0.0805
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0012 0.0061 0.0819
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0008 0.0024
Toxoplasma gondii Alpha-galactosidase 0.0014 0.0094 0.0778
Loa Loa (eye worm) hypothetical protein 0.0033 0.0332 0.089
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0734 0.1466
Schistosoma mansoni diacylglycerol kinase theta 0.0016 0.0124 0.0245
Echinococcus multilocularis protein kinase c iota type 0.0079 0.0925 0.0924
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0039 0.0416 0.0415
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.1187 0.2372
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0039 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0008 0.0013
Echinococcus granulosus NDR protein kinase 0.0007 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0124 0.033
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0039 0.0121
Schistosoma mansoni lipoxygenase 0.0168 0.2067 0.4132
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.1187 0.2372
Echinococcus granulosus Polycystic kidney disease protein 0.0038 0.0404 0.0805
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0039 0.0416 0.4405
Brugia malayi hypothetical protein 0.0019 0.0153 0.0486
Mycobacterium ulcerans epimerase 0.002 0.0164 0.0438
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0007 0.0008 0.0013
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0164 0.0521
Loa Loa (eye worm) AGC/PKA protein kinase 0.0039 0.0416 0.1117
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0947 0.1892
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.0008 0.0013
Echinococcus granulosus Diacylglycerol kinase theta 0.0016 0.0124 0.0245
Entamoeba histolytica hypothetical protein, conserved 0.0297 0.3715 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0153 0.0409
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0101
Trichomonas vaginalis bmru protein, putative 0.0012 0.0061 0.0196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0039 0.0101
Echinococcus granulosus dnaJ subfamily B 0.0398 0.5001 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0039 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0039 0.0121
Schistosoma mansoni serine/threonine kinase 0.0007 0.0008 0.0013
Onchocerca volvulus 0.0033 0.0332 0.1478
Schistosoma mansoni polycystin 1-related 0.0038 0.0404 0.0805
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0039 0.0121
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2021 0.6466
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0083 0.0164
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0204 0.2767
Echinococcus multilocularis RUN 0.0038 0.0404 0.0403
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0388 0.1041
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0271 0.0725
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0012 0.0061 0.012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0124 0.033
Echinococcus granulosus protein kinase c iota type 0.0079 0.0925 0.1847
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0037 0.0388 0.0773
Mycobacterium ulcerans hypothetical protein 0.002 0.0164 0.0438
Onchocerca volvulus 0.0026 0.0249 0.1058
Brugia malayi protein kinase C II. 0.0013 0.0083 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0092 0.0294
Echinococcus multilocularis serine:threonine protein kinase 38 0.0007 0.0008 0.0006
Loa Loa (eye worm) AGC/NDR protein kinase 0.0007 0.0008 0.0017
Brugia malayi Protein kinase domain containing protein 0.0007 0.0008 0.002
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0061 0.0819
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0008 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0416 0.083
Echinococcus multilocularis lamin dm0 0.0026 0.0249 0.0247
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0039 0.0075
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0039 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0061 0.0819
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0039 0.0101
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0669 0.1797
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0039 0.0075
Loa Loa (eye worm) hypothetical protein 0.001 0.0039 0.0101
Brugia malayi protein kinase C3,putative 0.0072 0.0838 0.2679
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0012 0.0061 0.0819
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0388 0.5272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0153 0.0409
Brugia malayi Ceramide kinase 0.0012 0.0061 0.0192
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0947 0.1892
Schistosoma mansoni hypothetical protein 0.0012 0.0061 0.012
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0734 0.0733
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0348 0.4732
Trypanosoma brucei rac serine-threonine kinase, putative 0.0007 0.0008 0.0086
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0061 0.0819
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.01 0.1187 0.2372
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0012 0.0061 0.0819
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.1187 0.2372
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0168 0.2067 0.2066
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0348 0.3561
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0249 0.0666
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0348 0.0918
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0734 0.1974
Echinococcus multilocularis serine threonine protein kinase 0.0008 0.0021 0.0019
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0164 0.0438
Loa Loa (eye worm) hypothetical protein 0.0039 0.0416 0.1117
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0002 0.0001
Schistosoma mansoni intermediate filament proteins 0.0026 0.0249 0.0495
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0039 0.0416 0.5659
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0669 0.1335
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2021 0.6466
Schistosoma mansoni hypothetical protein 0.0038 0.0404 0.0805
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0012 0.0061 0.006
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0039 0.0416 0.083
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0012 0.0061 0.0196
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0007 0.0008 0.0006
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0039 0.0075
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0008 0.0024
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0033 0.0332 0.089
Brugia malayi ecdysteroid receptor 0.001 0.0039 0.0121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0669 0.1797
Schistosoma mansoni lamin 0.0026 0.0249 0.0495
Leishmania major diacylglycerol kinase-like protein 0.0012 0.0061 0.0819
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0033 0.0332 0.1058
Echinococcus granulosus geminin 0.0165 0.2021 0.404
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2021 0.6466
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0669 0.9102
Loa Loa (eye worm) AGC/AKT protein kinase 0.0007 0.0008 0.0017
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0348 0.4732
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0012 0.0061 0.0506
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0074 0.0867 0.277
Onchocerca volvulus 0.0014 0.0092 0.0267
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0066 0.0763 0.2441
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0348 0.4732
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0039 0.0416 0.5659
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0037 0.0388 0.1025
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0039 0.0075
Echinococcus multilocularis musashi 0.0026 0.0249 0.0247
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0008 0.0024
Trypanosoma brucei Sphingosine kinase 0.0012 0.0061 0.0819
Schistosoma mansoni coup transcription factor 0.001 0.0039 0.0075
Loa Loa (eye worm) hypothetical protein 0.0297 0.3715 1
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0019 0.0153 0.0486
Trichomonas vaginalis AGC family protein kinase 0.0007 0.0008 0.0024
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0039 0.0416 0.083
Onchocerca volvulus 0.0019 0.0153 0.0577
Onchocerca volvulus 0.0033 0.0332 0.1478
Trypanosoma cruzi Sphingosine kinase 0.0012 0.0061 0.0819
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0204 0.2767
Echinococcus granulosus cpg binding protein 0.003 0.0291 0.0579
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0416 0.1102
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0204 0.0546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0039 0.0101
Schistosoma mansoni nuclear hormone receptor 0.001 0.0039 0.0075
Loa Loa (eye worm) hypothetical protein 0.0074 0.0867 0.233
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0039 0.0038
Schistosoma mansoni sphingoid long chain base kinase 0.0297 0.3715 0.7429
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0019 0.0153 0.0409
Onchocerca volvulus 0.0033 0.0332 0.1478
Schistosoma mansoni hypothetical protein 0.0165 0.2021 0.404
Schistosoma mansoni hypothetical protein 0.0165 0.2021 0.404
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0348 0.1114
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0039 0.0075
Echinococcus multilocularis protein kinase c epsilon type 0.0013 0.0083 0.0082
Echinococcus multilocularis transcription factor btf3 0.0034 0.0348 0.0347
Echinococcus multilocularis serine:threonine protein kinase N2 0.0007 0.0008 0.0006
Brugia malayi Doublecortin family protein 0.0038 0.0404 0.1288
Brugia malayi Eye-specific diacylglycerol kinase 0.0012 0.0061 0.0192
Brugia malayi hypothetical protein 0.0038 0.0404 0.1288
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0037 0.0388 0.3259
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.2021 0.6466
Toxoplasma gondii AGC kinase 0.0007 0.0008 0.0053

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 210 nM Binding affinity towards human neuropeptide Y receptor type 5 using [125I]-PYY as radiogigand in baculovirus-infected Sf9 cells ChEMBL. 14505677
Ki (binding) = 210 nM Binding affinity towards human neuropeptide Y receptor type 5 using [125I]-PYY as radiogigand in baculovirus-infected Sf9 cells ChEMBL. 14505677

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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