TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 274.322 | Formula: C13H18N6O
H donors: 1 H acceptors: 4 LogP: 0.57 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1onc(n1)CNCC1CCCN1c1cccnn1
InChi: 1S/C13H18N6O/c1-10-16-12(18-20-10)9-14-8-11-4-3-7-19(11)13-5-2-6-15-17-13/h2,5-6,11,14H,3-4,7-9H2,1H3
InChiKey: NAJZWZQZQALLPE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cell adhesion molecule	0.0004	0.0059	0.0136
Echinococcus granulosus	nephrin	0.0004	0.0059	0.0941
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0004	0.0059	0.0059
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0004	0.0059	0.0941
Schistosoma mansoni	cell adhesion molecule	0.0004	0.0059	0.0136
Schistosoma mansoni	neuroglian	0.0004	0.0059	0.0136
Onchocerca volvulus		0.0004	0.0059	0.193
Trypanosoma cruzi	bloodstream- specific protein 2 precursor	0.0004	0.011	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Trypanosoma brucei	protein disulfide isomerase	0.0004	0.011	0.0896
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0004	0.0059	0.0941
Echinococcus multilocularis	titin	0.0004	0.0059	0.0941
Brugia malayi	protein unc-22	0.0004	0.0059	0.0059
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0004	0.0059	0.0941
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0003	0.0026	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0004	0.0059	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0004	0.0059	0.0941
Schistosoma mansoni	cell adhesion molecule	0.0004	0.0059	0.0136
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0004	0.0059	0.0941
Brugia malayi	Transforming growth factor beta like domain containing protein	0.0009	0.0515	0.0515
Onchocerca volvulus		0.0004	0.0059	0.193
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0004	0.0059	0.0059
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0003	0.0026	0.0409
Echinococcus granulosus	protein disulfide isomerase	0.0004	0.011	0.1753
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Echinococcus granulosus	titin	0.0004	0.0059	0.0941
Echinococcus granulosus	Netrin receptor DCC	0.0004	0.0059	0.0941
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0003	0.0026	0.0026
Echinococcus multilocularis	anosmin 1	0.0004	0.0059	0.0941
Schistosoma mansoni	serine/threonine protein kinase	0.0004	0.0059	0.0136
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0004	0.0059	0.0059
Echinococcus granulosus	ecdysone induced protein 78C	0.0003	0.0026	0.0409
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0003	0.0026	0.0026
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0004	0.0059	0.0059
Brugia malayi	Fibronectin type III domain containing protein	0.0004	0.0059	0.0059
Brugia malayi	hypothetical protein	0.0004	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Schistosoma mansoni	nuclear hormone receptor	0.0003	0.0026	0.0059
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0004	0.0059	0.0941
Brugia malayi	hypothetical protein	0.0004	0.0059	0.0059
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0003	0.0026	0.0059
Brugia malayi	myotactin form A	0.0004	0.0059	0.0059
Echinococcus granulosus	usherin	0.0004	0.0059	0.0941
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.001	0.0626	1
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0026	0.0026
Echinococcus granulosus	anti dorsalizing morphogenetic protein 1a	0.0009	0.0515	0.8228
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0004	0.0059	0.0941
Brugia malayi	exodeoxyribonuclease III family protein	0.001	0.0626	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0026	0.0026
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0004	0.0059	0.0941
Trichomonas vaginalis	ap endonuclease, putative	0.001	0.0626	1
Echinococcus multilocularis	transfer RNA-Phe	0.0004	0.0059	0.0941
Brugia malayi	probable protein disulfide-isomerase	0.0004	0.011	0.011
Loa Loa (eye worm)	myotactin form A	0.0004	0.0059	0.0059
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.001	0.0626	0.0626
Brugia malayi	Fibronectin type III domain containing protein	0.0004	0.0059	0.0059
Schistosoma mansoni	factor for adipocyte differentiation	0.0004	0.0059	0.0136
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0005	0.0198	0.1715
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0004	0.0059	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Echinococcus multilocularis	protein disulfide isomerase	0.0004	0.011	0.1753
Echinococcus granulosus	tissue type plasminogen activator	0.0005	0.0198	0.3167
Schistosoma mansoni	hypothetical protein	0.0004	0.0059	0.0136
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0003	0.0026	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0004	0.0059	0.0941
Schistosoma mansoni	hemicentin	0.0004	0.0059	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.001	0.0626	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0026	0.0026
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0003	0.0026	0.0026
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0004	0.0059	0.0136
Loa Loa (eye worm)	Pdia4 protein	0.0004	0.011	0.011
Echinococcus granulosus	Netrin receptor DCC	0.0004	0.0059	0.0941
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.001	0.0626	0.0522
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0003	0.0026	0.0026
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.001	0.0626	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0003	0.0026	0.0409
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.001	0.0626	1
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0004	0.0059	0.0059
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0004	0.0059	0.0136
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0004	0.0059	0.0941
Brugia malayi	Fibronectin type III domain containing protein	0.0004	0.0059	0.0059
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0004	0.0059	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0067	0.0067
Schistosoma mansoni	cell adhesion molecule	0.0004	0.0059	0.0136
Schistosoma mansoni	cell adhesion molecule	0.0004	0.0059	0.0136
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0004	0.0059	0.0059
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.001	0.0626	1
Echinococcus granulosus	roundabout 2	0.0004	0.0059	0.0941
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0003	0.0026	0.0026
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0004	0.0059	0.0941
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0004	0.0059	0.0059
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0003	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0026	0.0026
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0003	0.0026	0.0059
Schistosoma mansoni	RAR-like nuclear receptor	0.0003	0.0026	0.0059
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0004	0.0059	0.0941
Schistosoma mansoni	Probable protein disulfide-isomerase ER-60 precursor (ERP60)	0.0004	0.011	0.0253
Schistosoma mansoni	titin	0.0004	0.0059	0.0136
Echinococcus multilocularis	neuroglian	0.0004	0.0059	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Schistosoma mansoni	nephrin	0.0004	0.0059	0.0136
Onchocerca volvulus		0.0004	0.0059	0.193
Onchocerca volvulus		0.0004	0.0059	0.193
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0003	0.0026	0.0059
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0004	0.0059	0.0059
Echinococcus multilocularis	anosmin 1	0.0004	0.0059	0.0941
Onchocerca volvulus		0.0004	0.0059	0.193
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0003	0.0026	0.0059
Echinococcus multilocularis	tissue type plasminogen activator	0.0005	0.0198	0.3167
Echinococcus granulosus	EG95	0.0004	0.0059	0.0941
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0003	0.0026	0.0026
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0004	0.0059	0.0941
Echinococcus multilocularis	usherin	0.0004	0.0059	0.0941
Brugia malayi	protein disulphide isomerase	0.0004	0.011	0.011
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0004	0.0059	0.0941
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0004	0.0059	0.0941
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0003	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Brugia malayi	nuclear receptor NHR-88	0.0003	0.0026	0.0026
Echinococcus granulosus	contactin	0.0004	0.0059	0.0941
Loa Loa (eye worm)	protein disulfide isomerase	0.0004	0.011	0.011
Echinococcus multilocularis	FTZ F1 alpha	0.0003	0.0026	0.0409
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0004	0.0059	0.0059
Brugia malayi	Fibronectin type III domain containing protein	0.0004	0.0059	0.0059
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0004	0.0059	0.0941
Schistosoma mansoni	hypothetical protein	0.0004	0.0059	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0004	0.0059	0.0059
Echinococcus granulosus	anosmin 1	0.0004	0.0059	0.0941
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0004	0.0059	0.0059
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0004	0.0059	0.0059
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0004	0.0059	0.0136
Echinococcus multilocularis	ecdysone induced protein 78C	0.0003	0.0026	0.0409
Brugia malayi	SPRY domain containing protein	0.0004	0.0059	0.0059
Brugia malayi	steroid hormone receptor	0.0003	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0026	0.0026
Schistosoma mansoni	factor for adipocyte differentiation	0.0004	0.0059	0.0136
Giardia lamblia	Hypothetical protein	0.0118	1	1
Schistosoma mansoni	ephrin receptor	0.0004	0.0059	0.0136
Echinococcus granulosus	FTZ F1 alpha	0.0003	0.0026	0.0409
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.001	0.0626	1
Schistosoma mansoni	myosin-binding protein-related	0.0004	0.0059	0.0136
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0003	0.0026	0.0026
Onchocerca volvulus		0.0004	0.0059	0.193
Loa Loa (eye worm)	UNCoordinated family member	0.0004	0.0059	0.0059
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.001	0.0626	1
Echinococcus multilocularis	roundabout 2	0.0004	0.0059	0.0941
Echinococcus granulosus	anosmin 1	0.0004	0.0059	0.0941
Onchocerca volvulus		0.0004	0.0059	0.193
Schistosoma mansoni	hypothetical protein	0.0004	0.0059	0.0136
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0003	0.0026	0.0026
Toxoplasma gondii	kringle domain-containing protein	0.0005	0.0198	0.1715
Schistosoma mansoni	thyroid hormone receptor	0.0003	0.0026	0.0059
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0003	0.0026	0.0409
Plasmodium falciparum	cysteine repeat modular protein 1	0.0005	0.0198	0.1715
Echinococcus multilocularis	roundabout 2	0.0004	0.0059	0.0941
Schistosoma mansoni	thyroid hormone receptor	0.0003	0.0026	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Trichomonas vaginalis	protein disulfide isomerase, putative	0.0004	0.011	0.0009
Brugia malayi	photoreceptor-specific nuclear receptor	0.0003	0.0026	0.0026
Schistosoma mansoni	ap endonuclease	0.001	0.0626	0.1444
Brugia malayi	myotactin form B	0.0004	0.0059	0.0059
Echinococcus granulosus	titin	0.0004	0.0059	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0016	0.1156	0.1156
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0004	0.0059	0.0059
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0004	0.0059	0.0059
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0004	0.0059	0.0059
Schistosoma mansoni	tripartite motif protein trim9	0.0004	0.0059	0.0136
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0003	0.0026	0.0409
Schistosoma mansoni	ap endonuclease	0.001	0.0626	0.1444
Loa Loa (eye worm)	lethal protein 805	0.0004	0.0059	0.0059
Brugia malayi	Fibronectin type III domain containing protein	0.0004	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Loa Loa (eye worm)	CAMK protein kinase	0.0004	0.0059	0.0059
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0003	0.0026	0.0026
Schistosoma mansoni	protein disulfide-isomerase er-60 precursor (erp60)	0.0004	0.011	0.0253
Echinococcus multilocularis	roundabout 2	0.0004	0.0059	0.0941
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0004	0.0059	0.0059
Schistosoma mansoni	hypothetical protein	0.0005	0.0198	0.0457
Echinococcus granulosus	G1Y162 protein	0.0004	0.0059	0.0941
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0004	0.0059	0.0059
Brugia malayi	ecdysteroid receptor	0.0003	0.0026	0.0026
Loa Loa (eye worm)	steroid hormone receptor	0.0003	0.0026	0.0026
Brugia malayi	Protein-tyrosine phosphatase	0.0004	0.0059	0.0059
Echinococcus granulosus	protein disulfide isomerase A3	0.0004	0.011	0.1753
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0003	0.0026	0.0026
Onchocerca volvulus		0.0004	0.0059	0.193
Echinococcus granulosus	neuroglian	0.0004	0.0059	0.0941
Echinococcus granulosus	Fibronectin type III	0.0004	0.0059	0.0941
Loa Loa (eye worm)	transglutaminase	0.0004	0.011	0.011
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0003	0.0026	0.0409
Echinococcus granulosus	cell adhesion molecule	0.0004	0.0059	0.0941
Echinococcus granulosus	roundabout 2	0.0004	0.0059	0.0941
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0004	0.0059	0.0136
Echinococcus multilocularis	anosmin 1	0.0004	0.0059	0.0941
Trichomonas vaginalis	protein disulfide isomerase, putative	0.0004	0.011	0.0009
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0004	0.0059	0.0059
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0004	0.0059	0.0941
Echinococcus granulosus	anosmin 1	0.0004	0.0059	0.0941
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.001	0.0626	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0004	0.0059	0.0059
Onchocerca volvulus		0.0004	0.0059	0.193
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0004	0.0059	0.0941
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0003	0.0026	0.0026
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.001	0.0626	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0003	0.0026	0.0026
Brugia malayi	Fibronectin type III domain containing protein	0.0004	0.0059	0.0059
Onchocerca volvulus		0.0004	0.0059	0.193
Schistosoma mansoni	factor for adipocyte differentiation	0.0004	0.0059	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0026	0.0026
Echinococcus granulosus	roundabout 2	0.0004	0.0059	0.0941
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0003	0.0026	0.0409
Schistosoma mansoni	coup transcription factor	0.0003	0.0026	0.0059
Brugia malayi	Steroid receptor seven-up type 2	0.0003	0.0026	0.0026
Echinococcus multilocularis	cell adhesion molecule	0.0004	0.0059	0.0941
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0004	0.0059	0.0136
Onchocerca volvulus		0.0004	0.0059	0.193
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0003	0.0026	0.0026
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0004	0.0059	0.0059
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0003	0.0026	0.0409
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0004	0.0059	0.0941
Brugia malayi	Lethal protein 805	0.0004	0.0059	0.0059
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0003	0.0026	0.0059
Brugia malayi	nuclear hormone receptor	0.0003	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0003	0.0026	0.0026
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0004	0.0059	0.0059
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0003	0.0026	0.0409
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.001	0.0626	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0003	0.0026	0.0026
Echinococcus multilocularis	titin	0.0004	0.0059	0.0941
Schistosoma mansoni	titin	0.0004	0.0059	0.0136
Trichomonas vaginalis	ap endonuclease, putative	0.001	0.0626	1
Toxoplasma gondii	exonuclease III APE	0.001	0.0626	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0003	0.0026	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0118	1	1
Onchocerca volvulus		0.0004	0.009	0.3714
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0003	0.0026	0.0409
Brugia malayi	Fibroblast growth factor family protein	0.0118	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0004	0.0059	0.0059
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0003	0.0026	0.0059
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0004	0.0059	0.0059
Loa Loa (eye worm)	bone morphogenic protein 6	0.0009	0.0515	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0118	1	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.001	0.0626	0.5
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0188	0.0188
Onchocerca volvulus		0.0005	0.0198	1
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0053	0.4335	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0005	0.0198	0.0198
Leishmania major	hypothetical protein, conserved	0.0005	0.0198	0.2457
Trichomonas vaginalis	protein disulfide isomerase, putative	0.0004	0.011	0.0009
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0003	0.0026	0.0409
Echinococcus multilocularis	Fibronectin, type III	0.0004	0.0059	0.0941
Schistosoma mansoni	protein tyrosine phosphatase	0.0004	0.0059	0.0136
Schistosoma mansoni	nephrin	0.0004	0.0059	0.0136
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0004	0.0059	0.0059
Echinococcus multilocularis	anti dorsalizing morphogenetic protein 1a	0.0009	0.0515	0.8228
Echinococcus multilocularis	Netrin receptor DCC	0.0004	0.0059	0.0941
Brugia malayi	Nuclear hormone receptor-like 1	0.0003	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0198	0.0198
Schistosoma mansoni	retinoic acid receptor RXR	0.0003	0.0026	0.0059
Brugia malayi	transglutaminase	0.0004	0.011	0.011
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0003	0.0026	0.0026
Echinococcus multilocularis	Netrin receptor DCC	0.0004	0.0059	0.0941
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0004	0.0059	0.0059
Onchocerca volvulus		0.0004	0.0059	0.193
Onchocerca volvulus		0.0004	0.0059	0.193
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0003	0.0026	0.0026
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0003	0.0026	0.0409
Brugia malayi	Protein kinase domain containing protein	0.0016	0.1156	0.1156
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0003	0.0026	0.0026
Echinococcus multilocularis	protein disulfide isomerase A3	0.0004	0.011	0.1753
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0003	0.0026	0.0026
Onchocerca volvulus		0.0004	0.0059	0.193
Brugia malayi	Kringle domain containing protein	0.0005	0.0198	0.0198
Loa Loa (eye worm)	projectin	0.0004	0.0059	0.0059
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.001	0.0626	0.5
Leishmania major	protein disulfide isomerase	0.0004	0.011	0.0896
Brugia malayi	Protein kinase domain containing protein	0.0005	0.0198	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0059	0.0059
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0004	0.0059	0.0059
Trypanosoma cruzi	hypothetical protein, conserved	0.0005	0.0198	0.2457
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0003	0.0026	0.0409
Schistosoma mansoni	protein disulfide-isomerase	0.0004	0.011	0.0253
Brugia malayi	Lethal protein 805	0.0004	0.0059	0.0059
Schistosoma mansoni	titin	0.0004	0.0059	0.0136
Treponema pallidum	exodeoxyribonuclease (exoA)	0.001	0.0626	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3497068

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2071043