TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.375 | Formula: C20H30BrN3O2
H donors: 1 H acceptors: 1 LogP: 4.71 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)OCCc1[nH]nc(c1)C1CCN(C1)CC(C)C.Br
InChi: 1S/C20H29N3O2.BrH/c1-15(2)13-23-10-8-16(14-23)20-12-17(21-22-20)9-11-25-19-6-4-18(24-3)5-7-19;/h4-7,12,15-16H,8-11,13-14H2,1-3H3,(H,21,22);1H
InChiKey: QCYWEGNKBRWLCN-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	major facilitator superfamily domain containing protein	0.0012	0.0002	0.0002
Plasmodium falciparum	major facilitator superfamily-related transporter, putative	0.0012	0.0002	0.1233
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Schistosoma mansoni	solute carrier family 37 member 2 (glycerol-3-phosphate transporter	0.0012	0.0002	0.0002
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0008	0.0008
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0015	0.0005	0.2199
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0009	0.0008
Echinococcus granulosus	bloom syndrome protein	0.0023	0.001	0.001
Echinococcus granulosus	synaptic vesicular amine transporter	0.0012	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0012	0.0002	0.0002
Schistosoma mansoni	monocarboxylate transporter	0.0012	0.0002	0.0002
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0009	0.8027
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Echinococcus multilocularis	Glycerol 3 phosphate transporter	0.0012	0.0002	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Giardia lamblia	Major facilitator family transporter	0.0012	0.0002	0.2089
Giardia lamblia	Sugar transport family protein	0.0012	0.0002	0.2089
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0008	0.5623
Schistosoma mansoni	oxalate:formate antiporter	0.0012	0.0002	0.0002
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0008	0.9407
Schistosoma mansoni	monocarboxylate transporter	0.0012	0.0002	0.0002
Schistosoma mansoni	DNA polymerase eta	0.002	0.0009	0.0009
Schistosoma mansoni	solute carrier family 37 member 2 (glycerol-3-phosphate transporter	0.0012	0.0002	0.0002
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0028	0.0015	0.0015
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0009	1
Echinococcus multilocularis	solute carrier family 43	0.0012	0.0002	0.0002
Echinococcus multilocularis	oxalate:formate antiporter	0.0012	0.0002	0.0002
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0012	0.0002	0.1233
Brugia malayi	hypothetical protein	0.0012	0.0002	0.0002
Echinococcus granulosus	sugar phosphate exchanger	0.0012	0.0002	0.0002
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0015	0.0015
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0009	0.0009
Echinococcus granulosus	oxalate:formate antiporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	major facilitator superfamily domain containing protein	0.0012	0.0002	0.0002
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Echinococcus granulosus	oxalate:formate antiporter	0.0012	0.0002	0.0002
Echinococcus granulosus	synaptic vesicle 2 protein	0.0012	0.0002	0.0002
Brugia malayi	ERG2 and Sigma1 receptor like protein	1.082	0.8515	0.8515
Mycobacterium leprae	POSSIBLE INTEGRAL MEMBRANE EFFLUX PROTEIN EFPA	0.0012	0.0002	0.5
Schistosoma mansoni	monocarboxylate transporter	0.0012	0.0002	0.0002
Plasmodium falciparum	monocarboxylate transporter, putative	0.0012	0.0002	0.1233
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0008	0.5589
Echinococcus granulosus	oxalate:formate antiporter	0.0012	0.0002	0.0002
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0033	0.0033
Schistosoma mansoni	sugar transporter	0.0012	0.0002	0.0002
Giardia lamblia	Multidrug resistance protein B	0.0012	0.0002	0.2089
Schistosoma mansoni	solute carrier family 17 member 7 (vesicular glutamate transporter	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0015	0.0015
Echinococcus multilocularis	oxalate:formate antiporter	0.0012	0.0002	0.0002
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0028	0.0015	1
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0012	0.0002	0.0002
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0009	0.0009
Onchocerca volvulus		0.0166	0.0123	0.0121
Giardia lamblia	DINP protein human, muc B family	0.002	0.0009	1
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0008	0.0008
Brugia malayi	probable sodium-dependent inorganic phosphate cotransporter	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hippocampus abundant transcript 1a	0.0012	0.0002	0.0002
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Echinococcus granulosus	sodium dependent phosphate transport protein 1	0.0012	0.0002	0.0002
Echinococcus granulosus	Major facilitator superfamily general substrate transporter	0.0012	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0179	0.0134	0.0134
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0009	0.0009
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0028	0.0015	0.0015
Schistosoma mansoni	blooms syndrome DNA helicase	0.0018	0.0007	0.0007
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0008	0.9407
Echinococcus multilocularis	oxalate:formate antiporter	0.0012	0.0002	0.0002
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0028	0.0015	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0008	0.0008
Echinococcus granulosus	sodium and chloride dependent glycine	0.0028	0.0015	0.0015
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0009	0.0009
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	1.082	0.8515	0.8515
Echinococcus granulosus	survival motor neuron protein 1	0.025	0.019	0.019
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Onchocerca volvulus		0.0028	0.0015	0.0013
Plasmodium falciparum	monocarboxylate transporter, putative	0.0012	0.0002	0.1233
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	1.2705	1	1
Loa Loa (eye worm)	hypothetical protein	0.025	0.019	0.019
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0012	0.0002	0.0002
Toxoplasma gondii	hypothetical protein	0.0012	0.0002	0.1233
Echinococcus granulosus	dna polymerase kappa	0.002	0.0009	0.0009
Brugia malayi	hypothetical protein	0.0028	0.0015	0.0015
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Toxoplasma gondii	hypothetical protein	0.0012	0.0002	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0015	0.0015
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0009	0.0008
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0004	0.0002
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0028	0.0015	1
Schistosoma mansoni	drug transporter	0.0012	0.0002	0.0002
Schistosoma mansoni	sialin (solute carrier family 17 member 5) (sodium/sialic acid cotransporter) (ast) (membrane glycoprotein hp59)	0.0012	0.0002	0.0002
Treponema pallidum	sodium- and chloride- dependent transporter	0.0166	0.0123	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0028	0.0015	0.0015
Schistosoma mansoni	sodium-dependent phosphate transporter	0.0012	0.0002	0.0002
Trypanosoma brucei	unspecified product	0.0014	0.0004	0.0002
Brugia malayi	hypothetical protein	0.0012	0.0002	0.0002
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0009	0.0008
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.0009	1
Leishmania major	C-8 sterol isomerase-like protein	1.082	0.8515	1
Mycobacterium leprae	Aminoglycoside/tetracycline-transport integral membrane protein	0.0012	0.0002	0.5
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0028	0.0015	1
Echinococcus granulosus	monocarboxylate transporter	0.0012	0.0002	0.0002
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Schistosoma mansoni	oxalate:formate antiporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	sodium dependent phosphate transport protein 1	0.0012	0.0002	0.0002
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0009	0.0009
Echinococcus granulosus	Hippocampus abundant transcript 1 protein	0.0012	0.0002	0.0002
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Schistosoma mansoni	hypothetical protein	0.0051	0.0033	0.0033
Echinococcus multilocularis	geminin	0.0179	0.0134	0.0134
Echinococcus granulosus	oxalate:formate antiporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	vesicular glutamate transporter	0.0012	0.0002	0.0002
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0166	0.0123	0.0123
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Toxoplasma gondii	exonuclease III APE	0.002	0.0008	0.5623
Brugia malayi	transporter	0.0012	0.0002	0.0002
Echinococcus granulosus	serotonin transporter	0.0166	0.0123	0.0123
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0028	0.0015	0.0015
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Echinococcus multilocularis	oxalate:formate antiporter	0.0012	0.0002	0.0002
Echinococcus granulosus	monocarboxylate transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	monocarboxylate transporter	0.0012	0.0002	0.0002
Trypanosoma brucei	C-8 sterol isomerase, putative	1.082	0.8515	1
Schistosoma mansoni	hypothetical protein	0.0012	0.0002	0.0002
Trypanosoma cruzi	C-8 sterol isomerase, putative	1.082	0.8515	1
Loa Loa (eye worm)	abnormal catecholamine distribution protein 1	0.0012	0.0002	0.0002
Loa Loa (eye worm)	serotonin transporter b	0.0166	0.0123	0.0123
Echinococcus granulosus	monocarboxylate transporter	0.0012	0.0002	0.0002
Giardia lamblia	Multidrug resistance protein B	0.0012	0.0002	0.2089
Toxoplasma gondii	zinc finger protein 36 family 3 protein	0.0012	0.0002	0.1233
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Echinococcus granulosus	solute carrier family 43	0.0012	0.0002	0.0002
Schistosoma mansoni	monocarboxylate transporter	0.0012	0.0002	0.0002
Echinococcus granulosus	oxalate:formate antiporter	0.0012	0.0002	0.0002
Schistosoma mansoni	oxalate:formate antiporter	0.0012	0.0002	0.0002
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Toxoplasma gondii	hypothetical protein	0.0028	0.0015	1
Schistosoma mansoni	monocarboxylate transporter	0.0012	0.0002	0.0002
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0028	0.0015	0.0015
Echinococcus granulosus	oxalate:formate antiporter	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.553	0.4349	0.4349
Echinococcus multilocularis	MFS transporter ceroid lipofuscinosis neuronal	0.0012	0.0002	0.0002
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0033	0.0033
Echinococcus granulosus	Solute carrier family 22 5	0.0012	0.0002	0.0002
Schistosoma mansoni	drug efflux protein-related	0.0012	0.0002	0.0002
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0028	0.0015	0.0015
Echinococcus granulosus	monocarboxylate transporter	0.0012	0.0002	0.0002
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0012	0.0002	0.1233
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Echinococcus granulosus	monocarboxylate transporter	0.0012	0.0002	0.0002
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0009	1
Plasmodium falciparum	metabolite/drug transporter, putative	0.0012	0.0002	0.1233
Echinococcus granulosus	vesicular acetylcholine transporter	1.2705	1	1
Onchocerca volvulus		0.0028	0.0015	0.0013
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Toxoplasma gondii	hypothetical protein	0.0012	0.0002	0.1233
Giardia lamblia	Hypothetical protein	0.0012	0.0002	0.2089
Echinococcus multilocularis	sugar phosphate exchanger solute carrier family	0.0012	0.0002	0.0002
Schistosoma mansoni	feline leukemia virus subgroup C receptor-related	0.0012	0.0002	0.0002
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0028	0.0015	0.0015
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	Major facilitator superfamily, general substrate transporter	0.0012	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0012	0.0002	0.0002
Schistosoma mansoni	sugar transporter	0.0012	0.0002	0.0002
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Mycobacterium leprae	PROBABLE NITRITE EXTRUSION PROTEIN 1 NARK (NITRITE FACILITATOR 1)	0.0012	0.0002	0.5
Echinococcus multilocularis	solute carrier family 43	0.0012	0.0002	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Echinococcus granulosus	Glycerol 3 phosphate transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	monocarboxylate transporter	0.0012	0.0002	0.0002
Giardia lamblia	hypothetical protein	0.0012	0.0002	0.2089
Echinococcus multilocularis	protein spinster	0.0012	0.0002	0.0002
Echinococcus granulosus	vesicular glutamate transporter	0.0012	0.0002	0.0002
Echinococcus granulosus	protein spinster	0.0012	0.0002	0.0002
Echinococcus granulosus	Major facilitator superfamily general substrate transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	oxalate:formate antiporter	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Echinococcus multilocularis	monocarboxylate transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	serotonin transporter	0.0166	0.0123	0.0123
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Echinococcus multilocularis	Major facilitator superfamily, general substrate transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	survival motor neuron protein 1	0.025	0.019	0.019
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0008	0.0008
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0009	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0012	0.0002	0.0002
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Schistosoma mansoni	phosphate transporter	0.0012	0.0002	0.0002
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0008	0.7551
Echinococcus granulosus	major facilitator superfamily domain containing protein	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0015	0.0015
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0028	0.0015	0.0015
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0012	0.0002	0.0002
Brugia malayi	transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	monocarboxylate transporter	0.0012	0.0002	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0004	0.0002
Onchocerca volvulus		0.0028	0.0015	0.0013
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0012	0.0002	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0015	0.0015
Schistosoma mansoni	hypothetical protein	0.0179	0.0134	0.0134
Echinococcus granulosus	sodium and chloride dependent glycine	0.0028	0.0015	0.0015
Mycobacterium leprae	POSSIBLE CONSERVED TRANSMEMBRANE PROTEIN	0.0012	0.0002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0008	0.0008
Echinococcus multilocularis	monocarboxylate transporter	0.0012	0.0002	0.0002
Schistosoma mansoni	monocarboxylate transporter	0.0012	0.0002	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Echinococcus granulosus	oxalate:formate antiporter	0.0012	0.0002	0.0002
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0009	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Trichomonas vaginalis	DNA helicase recq, putative	0.0023	0.001	1
Plasmodium vivax	amine transporter, putative	0.0028	0.0015	1
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Schistosoma mansoni	transport proetin (smap-4-related)	0.0012	0.0002	0.0002
Echinococcus multilocularis	oxalate:formate antiporter	0.0012	0.0002	0.0002
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0028	0.0015	0.0015
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0008	0.7551
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0012	0.0002	0.0002
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0015	0.0005	0.3064
Schistosoma mansoni	ap endonuclease	0.002	0.0008	0.0008
Schistosoma mansoni	adenylate cyclase	0.0012	0.0002	0.0002
Schistosoma mansoni	feline leukemia virus subgroup C receptor-related	0.0012	0.0002	0.0002
Toxoplasma gondii	hypothetical protein	0.0028	0.0015	1
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0166	0.0123	0.0123
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0009	0.0009
Schistosoma mansoni	protein transport protein Sec13	0.0012	0.0002	0.0002
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0009	0.0009
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0028	0.0015	0.0015
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0009	0.8027
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0008	0.0008
Echinococcus multilocularis	monocarboxylate transporter	0.0012	0.0002	0.0002
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0028	0.0015	0.0015
Plasmodium falciparum	major facilitator superfamily-related transporter, putative	0.0012	0.0002	0.1233
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0008	0.5007
Loa Loa (eye worm)	hypothetical protein	0.002	0.0009	0.0009
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0012	0.0002	0.0002
Schistosoma mansoni	sodium/chloride dependent transporter	0.0028	0.0015	0.0015
Trypanosoma brucei	unspecified product	0.002	0.0009	0.0008
Echinococcus granulosus	oxalate:formate antiporter	0.0012	0.0002	0.0002
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Schistosoma mansoni	oxalate:formate antiporter	0.0012	0.0002	0.0002
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0028	0.0015	0.0015
Echinococcus multilocularis	oxalate:formate antiporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	Major facilitator superfamily, general substrate transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	bloom syndrome protein	0.0023	0.001	0.001
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0028	0.0015	0.0015
Echinococcus granulosus	major facilitator superfamily domain containing protein	0.0012	0.0002	0.0002
Echinococcus granulosus	Major facilitator superfamily general substrate transporter	0.0012	0.0002	0.0002
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0008	0.9407
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	1.2705	1	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0012	0.0002	0.0002
Schistosoma mansoni	transporter spinster-related	0.0012	0.0002	0.0002
Giardia lamblia	Hypothetical protein	0.0012	0.0002	0.2089
Echinococcus granulosus	synaptic vesicle 2 protein	0.0012	0.0002	0.0002
Echinococcus multilocularis	vesicular glutamate transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	monocarboxylate transporter	0.0012	0.0002	0.0002
Brugia malayi	hypothetical protein	0.0012	0.0002	0.0002
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Giardia lamblia	MDR-type permease	0.0012	0.0002	0.2089
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0028	0.0015	0.0015
Echinococcus multilocularis	dna polymerase eta	0.002	0.0009	0.0009
Echinococcus granulosus	monocarboxylate transporter	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Giardia lamblia	Hypothetical protein	0.0012	0.0002	0.2089
Schistosoma mansoni	tetracycline-efflux transporter	0.0012	0.0002	0.0002
Schistosoma mansoni	phosphate transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	major facilitator superfamily domain containing protein	0.0012	0.0002	0.0002
Echinococcus multilocularis	oxalate:formate antiporter	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.0000000000033455	0.000000002256
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0028	0.0015	0.0015
Schistosoma mansoni	vesicular acetylcholine transporter	1.2705	1	1
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Schistosoma mansoni	sodium/chloride dependent transporter	0.0028	0.0015	0.0015
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Plasmodium falciparum	major facilitator superfamily-related transporter, putative	0.0012	0.0002	0.1233
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Echinococcus granulosus	monocarboxylate transporter	0.0012	0.0002	0.0002
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0028	0.0015	0.0015
Loa Loa (eye worm)	norepinephrine transporter	0.0166	0.0123	0.0123
Echinococcus granulosus	dna polymerase eta	0.002	0.0009	0.0009
Echinococcus granulosus	feline leukemia virus subgroup C	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0123	0.0123
Trichomonas vaginalis	DNA helicase recq, putative	0.0012	0.0002	0.0386
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0008	1
Echinococcus granulosus	solute carrier family 43	0.0012	0.0002	0.0002
Echinococcus multilocularis	MFS transporter ceroid lipofuscinosis neuronal	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0028	0.0015	0.0015
Schistosoma mansoni	monocarboxylate transporter	0.0012	0.0002	0.0002
Giardia lamblia	Hypothetical protein	0.0012	0.0002	0.2089
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0028	0.0015	0.0015
Leishmania major	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0015	0.0015
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Echinococcus granulosus	monocarboxylate transporter	0.0012	0.0002	0.0002
Schistosoma mansoni	drug efflux protein-related	0.0012	0.0002	0.0002
Entamoeba histolytica	recQ family helicase, putative	0.0012	0.0002	0.0481
Echinococcus granulosus	vesicular glutamate transporter	0.0012	0.0002	0.0002
Schistosoma mansoni	selectively expressed in embryonic epithelia protein-1	0.0012	0.0002	0.0002
Brugia malayi	Bloom's syndrome protein homolog	0.0023	0.001	0.001
Echinococcus multilocularis	oxalate:formate antiporter	0.0012	0.0002	0.0002
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0248	0.0188	0.0188
Echinococcus granulosus	geminin	0.0179	0.0134	0.0134
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0012	0.0002	0.0002
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0015	0.0015
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0008	0.9531
Toxoplasma gondii	transporter, major facilitator family protein	0.0012	0.0002	0.1233
Schistosoma mansoni	monocarboxylate transporter	0.0012	0.0002	0.0002
Brugia malayi	hypothetical protein	0.0012	0.0002	0.0002
Schistosoma mansoni	solute carrier family 37 member 2 (glycerol-3-phosphate transporter	0.0012	0.0002	0.0002
Plasmodium falciparum	amino acid transporter, putative	0.0028	0.0015	1
Schistosoma mansoni	sodium/sialic acid cotransporter	0.0012	0.0002	0.0002
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Schistosoma mansoni	oxalate:formate antiporter	0.0012	0.0002	0.0002
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0009	0.0008
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0028	0.0015	0.0015
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0012	0.0002	0.0002
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Echinococcus multilocularis	oxalate:formate antiporter	0.0012	0.0002	0.0002
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0028	0.0015	0.0015
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0008	0.0008
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0028	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Giardia lamblia	Hypothetical protein	0.0012	0.0002	0.2089
Echinococcus granulosus	oxalate:formate antiporter	0.0012	0.0002	0.0002
Trypanosoma brucei	unspecified product	0.0014	0.0004	0.0002
Echinococcus multilocularis	synaptic vesicular amine transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	vesicular acetylcholine transporter	1.2705	1	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0166	0.0123	0.0123
Echinococcus granulosus	MFS transporter ceroid lipofuscinosis neuronal	0.0012	0.0002	0.0002
Brugia malayi	Hypothetical transporter C09D4.1	0.0012	0.0002	0.0002
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0009	0.0008
Schistosoma mansoni	monocarboxylate transporter	0.0012	0.0002	0.0002
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0009	0.0009
Echinococcus granulosus	Major facilitator superfamily general substrate transporter	0.0012	0.0002	0.0002
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Echinococcus granulosus	MFS transporter ceroid lipofuscinosis neuronal	0.0012	0.0002	0.0002
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0012	0.0002	0.1233
Schistosoma mansoni	vesicular amine transporter	0.0012	0.0002	0.0002
Onchocerca volvulus		0.0051	0.0033	0.0031
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0028	0.0015	0.0015
Schistosoma mansoni	sodium/chloride dependent transporter	0.0166	0.0123	0.0123
Echinococcus granulosus	sugar phosphate exchanger 3	0.0012	0.0002	0.0002
Loa Loa (eye worm)	RecQ helicase	0.0023	0.001	0.001
Schistosoma mansoni	vesicular amine transporter	0.0012	0.0002	0.0002
Brugia malayi	Abnormal catecholamine distribution protein 1	0.0012	0.0002	0.0002
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0028	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Leishmania major	DNA polymerase eta, putative	0.002	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0012	0.0002	0.0002
Brugia malayi	Major Facilitator Superfamily protein	0.0012	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Echinococcus multilocularis	Major facilitator superfamily, general substrate transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	Hippocampus abundant transcript 1 protein	0.0012	0.0002	0.0002
Echinococcus granulosus	major facilitator superfamily domain containing protein	0.0012	0.0002	0.0002
Echinococcus multilocularis	feline leukemia virus subgroup C	0.0012	0.0002	0.0002
Brugia malayi	follicle stimulating hormone receptor	0.0248	0.0188	0.0188
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0009	0.0008
Echinococcus multilocularis	sugar phosphate exchanger 3	0.0012	0.0002	0.0002
Plasmodium falciparum	transporter, putative	0.0028	0.0015	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0004	0.0002
Schistosoma mansoni	monocarboxylate transporter	0.0012	0.0002	0.0002
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.0015	1
Schistosoma mansoni	ap endonuclease	0.002	0.0008	0.0008
Brugia malayi	hypothetical protein	0.025	0.019	0.019
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0123	0.0123
Plasmodium falciparum	pantothenate transporter	0.0012	0.0002	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0002	0.0002
Schistosoma mansoni	monocarboxylate transporter	0.0012	0.0002	0.0002
Echinococcus multilocularis	transfer RNA-Leu	0.0012	0.0002	0.0002
Trichomonas vaginalis	DNA helicase recq1, putative	0.0023	0.001	1
Giardia lamblia	TM efflux prot	0.0012	0.0002	0.2089
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0028	0.0015	0.0015

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3504857

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 2072862