Detailed information for compound 209467

Basic information

Technical information
  • TDR Targets ID: 209467
  • Name: (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzyl- 3-phenylpropanoyl)-methylamino]-3-methylbutan oyl]amino]-3,3-dimethylbutanoyl]amino]-4-oxo- 4-pyrrolidin-1-ylbutanoyl]amino]-4-[[(2S)-1-h ydroxy-4,4-dimethylpentan-2-yl]amino]-4-oxobu tanoic acid
  • MW: 863.093 | Formula: C47H70N6O9
  • H donors: 6 H acceptors: 9 LogP: 5.06 Rotable bonds: 29
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@H](CC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)N1CCCC1)NC(=O)[C@H](C(C)(C)C)NC(=O)[C@@H](N(C(=O)C(Cc1ccccc1)Cc1ccccc1)C)C(C)C)CC(=O)O
  • InChi: 1S/C47H70N6O9/c1-30(2)39(52(9)45(62)33(24-31-18-12-10-13-19-31)25-32-20-14-11-15-21-32)43(60)51-40(47(6,7)8)44(61)50-35(26-37(55)53-22-16-17-23-53)42(59)49-36(27-38(56)57)41(58)48-34(29-54)28-46(3,4)5/h10-15,18-21,30,33-36,39-40,54H,16-17,22-29H2,1-9H3,(H,48,58)(H,49,59)(H,50,61)(H,51,60)(H,56,57)/t34-,35-,36-,39-,40+/m0/s1
  • InChiKey: UCIMDOSRCVIHNC-CFUBTRTNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzyl-3-phenyl-propanoyl)-methyl-amino]-3-methyl-butanoyl]amino]-3,3-dimethyl-butanoyl]amino]-4-oxo-4-pyrrolidin-1-yl-butanoyl]amino]-4-[[(1S)-1-(hydroxymethyl)-3,3-dimethyl-butyl]amino]-4-oxo-butanoic acid
  • (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzyl-1-oxo-3-phenylpropyl)-methylamino]-3-methyl-1-oxobutyl]amino]-3,3-dimethyl-1-oxobutyl]amino]-1,4-dioxo-4-(1-pyrrolidinyl)butyl]amino]-4-[[(1S)-1-(hydroxymethyl)-3,3-dimethylbutyl]amino]-4-oxobutanoic acid
  • (3S)-3-[[(2S)-2-[[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-[methyl-[3-phenyl-2-(phenylmethyl)propanoyl]amino]butanoyl]amino]butanoyl]amino]-4-oxo-4-pyrrolidin-1-yl-butanoyl]amino]-4-[[(2S)-1-hydroxy-4,4-dimethyl-pentan-2-yl]amino]-4-oxo-butanoic acid
  • (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-benzyl-3-phenyl-propanoyl)-methyl-amino]-3-methyl-butanoyl]amino]-3,3-dimethyl-butanoyl]amino]-4-keto-4-pyrrolidino-butanoyl]amino]-4-[[(1S)-3,3-dimethyl-1-methylol-butyl]amino]-4-keto-butyric acid
  • (3S)-3-[[(2S)-2-[[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-[methyl-[3-phenyl-2-(phenylmethyl)propanoyl]amino]butanoyl]amino]butanoyl]amino]-4-oxo-4-pyrrolidin-1-ylbutanoyl]amino]-4-[[(2S)-1-hydroxy-4,4-dimethylpentan-2-yl]amino]-4-oxobutanoic acid
  • (3S)-3-[[(2S)-2-[[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-[methyl-[3-phenyl-2-(phenylmethyl)propanoyl]amino]butanoyl]amino]butanoyl]amino]-4-oxo-4-pyrrolidin-1-yl-butanoyl]amino]-4-[[(1S)-1-(hydroxymethyl)-3,3-dimethyl-butyl]amino]-4-oxo-butanoic acid
  • (3S)-3-[[(2S)-2-[[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-[methyl-[1-oxo-3-phenyl-2-(phenylmethyl)propyl]amino]-1-oxobutyl]amino]-1-oxobutyl]amino]-1,4-dioxo-4-1-pyrrolidinylbutyl]amino]-4-[[(1S)-1-(hydroxymethyl)-3,3-dimethylbutyl]amino]-4-oxobutanoic acid
  • (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-(benzyl)-3-phenyl-propanoyl]-methyl-amino]-3-methyl-butanoyl]amino]-3,3-dimethyl-butanoyl]amino]-4-keto-4-pyrrolidin-1-yl-butanoyl]amino]-4-[[(1S)-3,3-dimethyl-1-methylol-butyl]amino]-4-keto-butyric acid
  • 3-[2-(2-{2-[(2-Benzyl-3-phenyl-propionyl)-methyl-amino]-3-methyl-butyrylamino}-3,3-dimethyl-butyrylamino)-4-oxo-4-pyrrolidin-1-yl-butyrylamino]-N-(1-hydroxymethyl-3,3-dimethyl-butyl)-succinamic acid
  • AIDS-188199
  • AIDS188199

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0022 0.2546
Schistosoma mansoni neuropeptide receptor 0.0026 0.0034 0.0036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0022 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0034 0.0036
Leishmania major trypanothione reductase 0.0051 0.0085 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Onchocerca volvulus 0.0026 0.0034 0.0001
Schistosoma mansoni histamine h1 receptor 0.0026 0.0034 0.0036
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0034 0.0036
Mycobacterium tuberculosis Probable reductase 0.0117 0.0218 0.8837
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0032 0.0035
Schistosoma mansoni amine GPCR 0.0026 0.0034 0.0036
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0044 0.0048
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0034 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0034 0.0036
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0027 0.0029
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0034 0.0036
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Trypanosoma brucei unspecified product 0.0021 0.0023 0.0017
Echinococcus granulosus fmrfamide receptor 0.0026 0.0034 0.0036
Echinococcus granulosus serotonin transporter 0.0149 0.0283 0.0307
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0085 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0022 0.253
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0034 0.0036
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.0218 0.8837
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0034 0.0036
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0034 0.0036
Echinococcus granulosus g protein coupled receptor 0.0026 0.0034 0.0036
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0022 0.8133
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.0032
Onchocerca volvulus 0.0026 0.0034 0.0001
Plasmodium falciparum thioredoxin reductase 0.0051 0.0085 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0047 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0017 0.0011
Brugia malayi Dopamine receptor protein 1 0.0026 0.0034 0.0034
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0034 0.0034
Onchocerca volvulus 0.0026 0.0034 0.0001
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0023 0.0025
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0034 0.0036
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0022 0.0204
Brugia malayi Pre-SET motif family protein 0.0032 0.0047 0.0047
Echinococcus granulosus somatostatin receptor 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.0032
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0034 0.0034
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0032 0.0035
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0034 0.0036
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Toxoplasma gondii thioredoxin reductase 0.0051 0.0085 1
Brugia malayi follicle stimulating hormone receptor 0.0271 0.0532 0.0532
Echinococcus granulosus survival motor neuron protein 1 0.0252 0.0493 0.0534
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.0245 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.0032
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0034 0.0036
Brugia malayi hypothetical protein 0.0252 0.0493 0.0493
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0022 0.0016
Leishmania major DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Echinococcus granulosus dna polymerase eta 0.0021 0.0023 0.0025
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0034 0.0036
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0023 0.0025
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0034 0.0036
Schistosoma mansoni myosin xvIII 0.0026 0.0034 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0017 0.0011
Schistosoma mansoni DNA polymerase eta 0.0021 0.0023 0.0025
Trypanosoma brucei C-8 sterol isomerase, putative 0.4936 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0085 0.0085
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0023 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Echinococcus multilocularis serotonin receptor 0.0026 0.0034 0.0036
Brugia malayi neuropeptide F receptor 0.0026 0.0034 0.0034
Brugia malayi GnHR receptor homolog 0.0026 0.0034 0.0034
Brugia malayi Serotonin receptor 0.0026 0.0034 0.0034
Echinococcus granulosus g protein coupled receptor 0.0026 0.0034 0.0036
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.0218 0.8837
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0034 0.0036
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0034 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0034 0.0036
Onchocerca volvulus 0.0026 0.0034 0.0001
Onchocerca volvulus 0.0026 0.0034 0.0001
Brugia malayi hypothetical protein 0.0025 0.0032 0.0032
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0034 0.0036
Echinococcus granulosus bloom syndrome protein 0.0023 0.0027 0.0029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0017 0.0011
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0017 0.0664
Onchocerca volvulus 0.0026 0.0034 0.0001
Trypanosoma cruzi C-8 sterol isomerase, putative 0.4936 1 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0017 0.2
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.3786
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0032 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Brugia malayi larval opioid receptor 0.0026 0.0034 0.0034
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0025 0.0032 0.0035
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0034 0.0036
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0017 0.0017
Plasmodium falciparum glutathione reductase 0.0018 0.0017 0.2
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0034 0.0036
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0032 0.0035
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0034 0.0036
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.0034 0.0001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0034 0.0036
Schistosoma mansoni biogenic amine receptor 0.0026 0.0034 0.0036
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0034 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Schistosoma mansoni adenoreceptor 0.0026 0.0034 0.0036
Onchocerca volvulus 0.0026 0.0034 0.0001
Plasmodium vivax SET domain protein, putative 0.0032 0.0047 0.4733
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0034 0.0036
Echinococcus multilocularis serotonin receptor 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0025 0.0032 0.0035
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0032 0.0035
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0047 0.0051
Giardia lamblia DINP protein human, muc B family 0.0021 0.0023 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0034 0.0036
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.0034 0.0036
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0023 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Brugia malayi glutathione reductase 0.0051 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0017 0.2
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0022 0.0016
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Brugia malayi G-protein coupled receptor 0.0026 0.0034 0.0034
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0034 0.0036
Schistosoma mansoni hypothetical protein 0.0051 0.0085 0.0092
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0017 0.2
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0022 0.0323
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0017 0.0011
Schistosoma mansoni hypothetical protein 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.0218 0.8837
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0034 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0034 0.0036
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0034 0.0036
Echinococcus multilocularis somatostatin receptor 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Schistosoma mansoni neuropeptide receptor 0.0026 0.0034 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0047 0.0051
Brugia malayi G protein-coupled receptor 0.0026 0.0034 0.0034
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0022 0.0323
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0034 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0023 0.0023
Echinococcus granulosus dna polymerase kappa 0.0021 0.0023 0.0025
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0032 0.0035
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.0032
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0027 0.0027
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0034 0.0036
Schistosoma mansoni neuropeptide receptor 0.0026 0.0034 0.0036
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0017 0.0229
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0034 0.0034
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.0034 0.0036
Echinococcus multilocularis geminin 0.0365 0.0721 0.0781
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0271 0.0532 0.0532
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0034 0.0036
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0034 0.0034
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.0245 1
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0034 0.0036
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0034 0.0036
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0032 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0017 0.0664
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0032 0.0035
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0022 0.0174
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0085 0.2985
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Schistosoma mansoni sodium/chloride dependent transporter 0.0149 0.0283 0.0307
Loa Loa (eye worm) RecQ helicase 0.0023 0.0027 0.0027
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0034 0.0036
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0027 0.0433
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0034 0.0034
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0252 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1087 0.2188 0.237
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0149 0.0283 0.0283
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0023 0.0017
Trypanosoma brucei unspecified product 0.0014 0.001 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0017 0.0011
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0085 0.0092
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.001 0.0004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0034 0.0036
Brugia malayi hypothetical protein 0.0026 0.0034 0.0034
Brugia malayi RE15519p 0.0026 0.0034 0.0034
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0034 0.0036
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0023 0.0025
Echinococcus granulosus orexin receptor type 2 0.0026 0.0034 0.0036
Echinococcus granulosus hypothetical protein 0.0026 0.0034 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0047 0.0051
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0017 0.0019
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0365 0.0721 0.0781
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Toxoplasma gondii hypothetical protein 0.0025 0.0032 0.3786
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0017 0.0018
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0034 0.0036
Brugia malayi hypothetical protein 0.0026 0.0034 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.001 0.0004
Loa Loa (eye worm) serotonin transporter b 0.0149 0.0283 0.0283
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0085 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0034 0.0036
Schistosoma mansoni amine GPCR 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.0032
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0023 0.0344
Brugia malayi hypothetical protein 0.0026 0.0034 0.0034
Schistosoma mansoni amine GPCR 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.0218 0.8837
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0034 0.0036
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0023 0.025
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0032 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Leishmania major DNA polymerase eta, putative 0.0021 0.0023 0.0017
Loa Loa (eye worm) hypothetical protein 0.0149 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0017 0.0011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0022 0.0023
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0025 0.0032 0.0035
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0226 0.0439 0.0439
Echinococcus multilocularis vesicular acetylcholine transporter 0.4557 0.9233 1
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0034 0.0036
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0034 0.0036
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0025 0.0032 0.0035
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Treponema pallidum sodium- and chloride- dependent transporter 0.0149 0.0283 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0032 0.0035
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0017 0.0011
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0034 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0017 0.0011
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0022 0.9377
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0023 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Onchocerca volvulus 0.0026 0.0034 0.0001
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0023 0.025
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0017 0.0011
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0047 0.0051
Onchocerca volvulus 0.0026 0.0034 0.0001
Schistosoma mansoni opsin-like receptor 0.0026 0.0034 0.0036
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0034 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0018
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0085 0.0085
Brugia malayi neuropeptide F receptor 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0149 0.0283 0.0283
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0025 0.0032 0.0035
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Trypanosoma brucei trypanothione reductase 0.0051 0.0085 0.0079
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0023 0.0023
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0034 0.0036
Echinococcus granulosus vesicular acetylcholine transporter 0.4557 0.9233 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.0032
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.3786
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.0032
Brugia malayi G-protein coupled receptor 0.0026 0.0034 0.0034
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0017 0.2
Brugia malayi sulfakinin receptor protein 0.0026 0.0034 0.0034
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0034 0.0036
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0034 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.3786
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0034 0.0036
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0022 0.0022
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0034 0.0036
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0027 0.0433
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0034 0.0036
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0034 0.0034
Brugia malayi Serotonin receptor 0.0026 0.0034 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0017 0.0018
Onchocerca volvulus 0.0026 0.0034 0.0001
Echinococcus granulosus neuropeptide s receptor 0.0026 0.0034 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0034 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0023 0.0344
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0023 1
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0017 0.0229
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0017 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Echinococcus granulosus serotonin receptor 0.0026 0.0034 0.0036
Echinococcus multilocularis dna polymerase eta 0.0021 0.0023 0.0025
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0034 0.0036
Brugia malayi AKH receptor 0.0026 0.0034 0.0034
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0023 0.0017
Loa Loa (eye worm) norepinephrine transporter 0.0149 0.0283 0.0283
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0034 0.0036
Echinococcus granulosus neuropeptide receptor 0.0026 0.0034 0.0036
Onchocerca volvulus 0.0051 0.0085 0.0058
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0034 0.0034
Schistosoma mansoni ap endonuclease 0.002 0.0022 0.0023
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.0218 0.8837
Onchocerca volvulus 0.0026 0.0034 0.0001
Echinococcus granulosus allatostatin A receptor 0.0026 0.0034 0.0036
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0023 1
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0023 0.0017
Plasmodium falciparum glutathione reductase 0.0051 0.0085 1
Toxoplasma gondii exonuclease III APE 0.002 0.0022 0.2546
Loa Loa (eye worm) hypothetical protein 0.4936 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0022 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0017 0.0011
Schistosoma mansoni hypothetical protein 0.0026 0.0034 0.0036
Schistosoma mansoni amine GPCR 0.0026 0.0034 0.0036
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.0245 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.001 0.0004
Schistosoma mansoni hypothetical protein 0.0026 0.0034 0.0036
Schistosoma mansoni ap endonuclease 0.002 0.0022 0.0023
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0034 0.0036
Echinococcus granulosus tm gpcr rhodopsin 0.1087 0.2188 0.237
Brugia malayi hypothetical protein 0.0026 0.0034 0.0034
Brugia malayi hypothetical protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Schistosoma mansoni biogenic amine receptor 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0032 0.0047 0.0047
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0007 0.0007
Plasmodium vivax glutathione reductase, putative 0.0051 0.0085 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0034 0.0036
Brugia malayi putative neuropeptide receptor 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Brugia malayi ORL1-like opioid receptor 0.0026 0.0034 0.0034
Echinococcus granulosus geminin 0.0365 0.0721 0.0781
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.4557 0.9233 0.9233
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Plasmodium vivax amine transporter, putative 0.0025 0.0032 0.2749
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0023 0.0025
Plasmodium falciparum transporter, putative 0.0025 0.0032 0.3786
Echinococcus multilocularis sex peptide receptor 0.0026 0.0034 0.0036
Onchocerca volvulus 0.0026 0.0034 0.0001
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0034 0.0036
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0034 0.0036
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0034 0.0036
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0034 0.0034
Echinococcus multilocularis serotonin transporter 0.0149 0.0283 0.0307
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0047 0.5486
Trichomonas vaginalis set domain proteins, putative 0.0257 0.0503 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0034 0.0036
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0017 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0017 0.0011
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0034 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0034 0.0034
Loa Loa (eye worm) glutathione reductase 0.0051 0.0085 0.0085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0034 0.0036
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0034 0.0036
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Schistosoma mansoni survival motor neuron protein 0.0051 0.0085 0.0092
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0032 0.0035
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0034 0.0036
Loa Loa (eye worm) solute carrier family 6 member 4 0.0149 0.0283 0.0283
Onchocerca volvulus 0.0026 0.0034 0.0001
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0032 0.0035
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0085 0.0092
Loa Loa (eye worm) hypothetical protein 0.2523 0.5102 0.5102
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.4557 0.9233 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0025 0.0032 0.0035
Brugia malayi Dopamine receptor 0.0026 0.0034 0.0034
Brugia malayi Dopamine receptor protein 2 0.0026 0.0034 0.0034
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0007 0.0007
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0034 0.0036
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0034 0.0036
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0032 0.0035
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0034 0.0036
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0034 0.0036
Onchocerca volvulus 0.0149 0.0283 0.0273
Loa Loa (eye worm) hypothetical protein 0.0025 0.0032 0.0032
Schistosoma mansoni vesicular acetylcholine transporter 0.4557 0.9233 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0017 0.0011
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0034 0.0034
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0023 0.0017
Schistosoma mansoni hypothetical protein 0.0026 0.0034 0.0036
Echinococcus multilocularis survival motor neuron protein 1 0.0252 0.0493 0.0534
Onchocerca volvulus 0.0026 0.0034 0.0001
Brugia malayi Thioredoxin reductase 0.0051 0.0085 0.0085
Brugia malayi Pre-SET motif family protein 0.0226 0.0439 0.0439
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.0032
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.0245 1
Trypanosoma brucei unspecified product 0.0014 0.001 0.0004
Schistosoma mansoni neuropeptide receptor 0.0026 0.0034 0.0036
Brugia malayi vesicular acetylcholine transporter unc-17 0.4557 0.9233 0.9233
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0034 0.0036
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0017 0.0018
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0017 0.0011
Echinococcus granulosus g protein coupled receptor 0.0026 0.0034 0.0036
Brugia malayi Melatonin receptor type 1A 0.0026 0.0034 0.0034
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0032 0.0032
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0012 0.1387
Onchocerca volvulus 0.0257 0.0503 0.0511
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0149 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.0034 0.0001
Onchocerca volvulus 0.0026 0.0034 0.0001
Plasmodium falciparum thioredoxin reductase 0.0018 0.0017 0.2
Plasmodium falciparum amino acid transporter, putative 0.0025 0.0032 0.3786
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0022 0.0023
Schistosoma mansoni biogenic amine receptor 0.0026 0.0034 0.0036
Echinococcus granulosus sex peptide receptor 0.0026 0.0034 0.0036
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0032 0.0035
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0034 0.0036
Brugia malayi hypothetical protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0365 0.0721 0.0781
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0034 0.0036
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0034 0.0036
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0034 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0047 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0047 0.0051
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0032 0.2749
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0025 0.0032 0.0032
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0032 0.0035
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0034 0.0034
Onchocerca volvulus 0.0026 0.0034 0.0001
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0149 0.0283 0.0307
Schistosoma mansoni opsin-like receptor 0.0026 0.0034 0.0036
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0022 1
Brugia malayi hypothetical protein 0.0026 0.0034 0.0034
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0017 0.0011
Brugia malayi hypothetical protein 0.0026 0.0034 0.0034
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0034 0.0036
Schistosoma mansoni amine GPCR 0.0026 0.0034 0.0036
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0017 0.7488
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0034 0.0036
Toxoplasma gondii hypothetical protein 0.0025 0.0032 0.3786
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0023 0.0017
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0022 0.1301
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0025 0.0032 1
Brugia malayi hypothetical protein 0.0026 0.0034 0.0034
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0023 0.0017
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0034 0.0036
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0034 0.0036
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0022 0.0022
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0032 0.0035
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0023
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0034 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Echinococcus granulosus neuropeptide receptor 0.0026 0.0034 0.0036
Onchocerca volvulus 0.0026 0.0034 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0034 0.0036
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0022 0.9531
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.0034 0.0036
Onchocerca volvulus 0.0032 0.0047 0.0016
Brugia malayi hypothetical protein 0.0026 0.0034 0.0034
Leishmania major C-8 sterol isomerase-like protein 0.4936 1 1
Schistosoma mansoni opsin-like receptor 0.0026 0.0034 0.0036

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 30 uM Inhibitory activity against HSV-1 in baby hamster kidney cell ChEMBL. 7658449
EC50 (functional) = 30 uM Inhibitory activity against HSV-1 in baby hamster kidney cell ChEMBL. 7658449
EC50 (functional) = 39 uM Inhibitory activity against HSV-2 in baby hamster kidney cell ChEMBL. 7658449
EC50 (functional) = 39 uM Inhibitory activity against HSV-2 in baby hamster kidney cell ChEMBL. 7658449

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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