TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 559.354 | Formula: C23H29Br2NO3S
H donors: 0 H acceptors: 3 LogP: 4.38 Rotable bonds: 3
Rule of 5 violations (Lipinski): 2
SMILES: BrC1C(Br)c2c(C31CCN(CC3)S(=O)(=O)C[C@]13CCC(C3(C)C)CC1=O)cccc2
InChi: 1S/C23H29Br2NO3S/c1-21(2)15-7-8-23(21,18(27)13-15)14-30(28,29)26-11-9-22(10-12-26)17-6-4-3-5-16(17)19(24)20(22)25/h3-6,15,19-20H,7-14H2,1-2H3/t15?,19?,20?,23-/m1/s1
InChiKey: OBSODVFXWXEQLQ-BJPVNYJMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Oxytocin receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Oxytocin receptor	388 aa	327 aa	23.9 %
Echinococcus multilocularis	orexin receptor type 2	Oxytocin receptor	388 aa	332 aa	23.2 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Oxytocin receptor	388 aa	323 aa	21.7 %
Echinococcus multilocularis	allatostatin A receptor	Oxytocin receptor	388 aa	311 aa	21.9 %
Echinococcus granulosus	orexin receptor type 2	Oxytocin receptor	388 aa	338 aa	24.3 %
Echinococcus multilocularis	neuropeptide receptor	Oxytocin receptor	388 aa	324 aa	21.6 %
Echinococcus granulosus	neuropeptide receptor	Oxytocin receptor	388 aa	324 aa	21.9 %
Onchocerca volvulus	Phospholipase d-related homolog	Oxytocin receptor	388 aa	330 aa	20.0 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Oxytocin receptor	388 aa	346 aa	24.0 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Oxytocin receptor	388 aa	327 aa	19.3 %
Echinococcus granulosus	allatostatin A receptor	Oxytocin receptor	388 aa	313 aa	23.6 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Oxytocin receptor	388 aa	349 aa	22.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Cathepsin L homolog	0.0794	0.3638	1
Giardia lamblia	Cathepsin B precursor	0.062	0.2808	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.3638	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0045	0.006
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1044	0.1021
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0045	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Onchocerca volvulus	Peroxidasin homolog	0.0038	0.0048	0.0062
Schistosoma mansoni	hypothetical protein	0.0038	0.0045	0.0012
Onchocerca volvulus		0.0038	0.0048	0.0062
Brugia malayi	hypothetical protein	0.0238	0.0997	0.0965
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0036	0.0036	0.5
Trypanosoma brucei	cysteine peptidase C (CPC)	0.062	0.2808	0.7697
Plasmodium falciparum	serine repeat antigen 6	0.0182	0.0731	0.1929
Onchocerca volvulus		0.0038	0.0045	0.0053
Onchocerca volvulus	Cathepsin L homolog	0.0182	0.0731	0.1952
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0045	0.0012
Trypanosoma cruzi	cysteine peptidase, putative	0.0794	0.3638	0.486
Entamoeba histolytica	cysteine protease, putative	0.043	0.1909	0.4054
Brugia malayi	Animal haem peroxidase family protein	0.0038	0.0048	0.0012
Loa Loa (eye worm)	TYRA-2 protein	0.0038	0.0045	0.0019
Onchocerca volvulus		0.0038	0.0045	0.0053
Entamoeba histolytica	cysteine protease, putative	0.043	0.1909	0.4054
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0038	0.0045	0.006
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0182	0.0731	0.1929
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Plasmodium falciparum	serine repeat antigen 4	0.0182	0.0731	0.1929
Brugia malayi	follicle stimulating hormone receptor	0.0038	0.0045	0.0009
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.3638	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0794	0.3638	0.4884
Onchocerca volvulus		0.0038	0.0048	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Onchocerca volvulus		0.0794	0.3638	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0057	0.0134	0.0133
Schistosoma mansoni	growth hormone secretagogue receptor	0.0038	0.0045	0.0012
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0045	0.0012
Loa Loa (eye worm)	animal heme peroxidase	0.0038	0.0048	0.0022
Brugia malayi	G protein-coupled receptor	0.0038	0.0045	0.0009
Echinococcus granulosus	cathepsin b	0.1597	0.7448	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0038	0.0045	0.0019
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0038	0.0045	0.0012
Giardia lamblia	Hypothetical protein	0.0182	0.0731	0.2506
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0038	0.0045	0.0012
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0169	0.0144
Schistosoma mansoni	amine GPCR	0.0038	0.0045	0.0012
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0038	0.0045	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0731	0.0707
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0045	0.0012
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0182	0.0731	0.1929
Plasmodium falciparum	serine repeat antigen 1	0.0182	0.0731	0.1929
Echinococcus multilocularis	serotonin receptor	0.0038	0.0045	0.006
Plasmodium vivax	serine-repeat antigen (SERA)	0.0182	0.0731	0.1929
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0045	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0036	0.001
Entamoeba histolytica	cysteine protease, putative	0.0794	0.3638	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.043	0.1909	0.4054
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0169	0.018
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0182	0.0731	0.0937
Schistosoma mansoni	microtubule-associated protein tau	0.0744	0.3397	0.4535
Trypanosoma cruzi	cruzipain precursor, putative	0.0794	0.3638	0.486
Echinococcus multilocularis	neuropeptide receptor A26	0.0038	0.0045	0.006
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0045	0.006
Onchocerca volvulus		0.0182	0.0731	0.1952
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Entamoeba histolytica	cysteine protease, putative	0.043	0.1909	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0546	0.2459	0.244
Trichomonas vaginalis	conserved hypothetical protein	0.0182	0.0731	0.1929
Mycobacterium ulcerans	pyruvate kinase	0.0036	0.0036	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0182	0.0731	0.1929
Onchocerca volvulus	Dual oxidase homolog	0.0038	0.0048	0.0062
Brugia malayi	putative neuropeptide receptor	0.0038	0.0045	0.0009
Loa Loa (eye worm)	cysteine protease	0.0794	0.3638	0.3621
Loa Loa (eye worm)	ctsf protein	0.0794	0.3638	0.3621
Schistosoma mansoni	cathepsin F (C01 family)	0.0546	0.2459	0.327
Echinococcus multilocularis	g-protein coupled receptor	0.0038	0.0045	0.006
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0182	0.0731	0.0707
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0045	0.006
Brugia malayi	Blistered cuticle protein 3	0.0038	0.0048	0.0012
Onchocerca volvulus		0.0038	0.0045	0.0053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0794	0.3638	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0182	0.0731	0.1929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.3638	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0794	0.3638	0.3621
Onchocerca volvulus		0.0038	0.0045	0.0053
Brugia malayi	Cathepsin L-like precursor	0.0794	0.3638	0.3615
Brugia malayi	AKH receptor	0.0038	0.0045	0.0009
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0045	0.006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0045	0.006
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Schistosoma mansoni	opsin-like receptor	0.0038	0.0045	0.0012
Giardia lamblia	Cysteine protease	0.0182	0.0731	0.2506
Brugia malayi	sulfakinin receptor protein	0.0038	0.0045	0.0009
Echinococcus multilocularis	calpain family protein 1, d	0.004	0.0055	0.0074
Echinococcus granulosus	geminin	0.0183	0.0733	0.094
Plasmodium vivax	vivapain-2	0.0794	0.3638	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.062	0.2808	0.374
Brugia malayi	hypothetical protein	0.0038	0.0045	0.0009
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0182	0.0731	0.2506
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0045	0.0012
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0169	0.018
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0045	0.006
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.3638	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0248	0.1044	0.1021
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.062	0.2808	0.374
Chlamydia trachomatis	pyruvate kinase	0.0036	0.0036	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.3638	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0182	0.0731	0.0937
Echinococcus granulosus	neuropeptide s receptor	0.0038	0.0045	0.0012
Brugia malayi	Animal haem peroxidase family protein	0.0038	0.0048	0.0012
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1597	0.7448	1
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0169	0.018
Echinococcus multilocularis	orexin receptor type 2	0.0038	0.0045	0.006
Plasmodium vivax	serine-repeat antigen (SERA)	0.0182	0.0731	0.1929
Entamoeba histolytica	cysteine protease, putative	0.043	0.1909	0.4054
Echinococcus multilocularis	cathepsin L	0.0182	0.0731	0.0981
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0045	0.006
Echinococcus multilocularis	cysteine protease	0.0794	0.3638	0.4884
Loa Loa (eye worm)	hypothetical protein	0.0546	0.2459	0.244
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0731	0.0707
Brugia malayi	Papain family cysteine protease containing protein	0.0794	0.3638	0.3615
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0292	0.0392
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0038	0.0045	0.0009
Brugia malayi	Papain family cysteine protease containing protein	0.0182	0.0731	0.0697
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.3638	1
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0045	0.0012
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0045	0.0012
Entamoeba histolytica	cysteine proteinase, putative	0.043	0.1909	0.4054
Onchocerca volvulus		0.0038	0.0045	0.0053
Entamoeba histolytica	cysteine protease, putative	0.043	0.1909	0.4054
Leishmania major	cathepsin L-like protease	0.0794	0.3638	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0182	0.0731	0.0697
Onchocerca volvulus	Peroxidase homolog	0.0038	0.0048	0.0062
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0045	0.0012
Brugia malayi	GnHR receptor homolog	0.0038	0.0045	0.0009
Echinococcus granulosus	G protein coupled receptor 139	0.0038	0.0045	0.0012
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0292	0.0345
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0169	0.0144
Leishmania major	cathepsin L-like protease	0.0794	0.3638	1
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1044	0.1021
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0045	0.006
Plasmodium vivax	vivapain-2	0.0794	0.3638	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0794	0.3638	0.486
Schistosoma mansoni	amine GPCR	0.0038	0.0045	0.0012
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.043	0.1909	0.2528
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0045	0.0012
Echinococcus multilocularis	dro:myosuppressin receptor	0.0038	0.0045	0.006
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0045	0.0019
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0182	0.0731	0.1929
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0182	0.0731	0.1929
Brugia malayi	neuropeptide F receptor	0.0038	0.0045	0.0009
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0169	0.018
Trypanosoma cruzi	cysteine peptidase, putative	0.0794	0.3638	0.486
Giardia lamblia	Cathepsin B precursor	0.0182	0.0731	0.2506
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0731	0.0707
Leishmania major	cathepsin L-like protease	0.0794	0.3638	1
Echinococcus granulosus	cathepsin b	0.1597	0.7448	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.3638	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.3638	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0038	0.0045	0.0012
Onchocerca volvulus		0.0794	0.3638	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0038	0.0045	0.0012
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0182	0.0731	0.0707
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.3638	1
Entamoeba histolytica	cysteine protease, putative	0.043	0.1909	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0794	0.3638	0.3615
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0182	0.0731	0.1929
Onchocerca volvulus		0.0038	0.0045	0.0053
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.3638	1
Leishmania major	cysteine peptidase A (CPA)	0.0794	0.3638	1
Onchocerca volvulus		0.0038	0.0045	0.0053
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1597	0.7448	1
Onchocerca volvulus	Peroxidasin homolog	0.0038	0.0048	0.0062
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0045	0.0012
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0182	0.0731	0.0697
Toxoplasma gondii	cathepsin CPL	0.0794	0.3638	1
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0731	0.0707
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0038	0.0045	0.0009
Echinococcus granulosus	cathepsin l1	0.0794	0.3638	0.486
Echinococcus granulosus	cathepsin l1	0.0546	0.2459	0.327
Echinococcus multilocularis	cysteine protease	0.0794	0.3638	0.4884
Schistosoma mansoni	myosin xvIII	0.0038	0.0045	0.0012
Entamoeba histolytica	cysteine protease, putative	0.043	0.1909	0.4054
Schistosoma mansoni	hypothetical protein	0.0038	0.0045	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Echinococcus granulosus	serotonin receptor	0.0038	0.0045	0.0012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0182	0.0731	0.1929
Loa Loa (eye worm)	hypothetical protein	0.1597	0.7448	0.7441
Echinococcus granulosus	g-protein coupled receptor	0.0038	0.0045	0.0012
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0045	0.0012
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.3638	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0038	0.0045	0.0012
Schistosoma mansoni	cathepsin C	0.0182	0.0731	0.0937
Entamoeba histolytica	cysteine protease, putative	0.043	0.1909	0.4054
Onchocerca volvulus		0.0794	0.3638	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.0292	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0022
Echinococcus granulosus	sex peptide receptor	0.0038	0.0045	0.0012
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0038	0.0045	0.0012
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0045	0.0012
Trypanosoma cruzi	cysteine proteinase, putative	0.043	0.1909	0.2528
Echinococcus multilocularis	cathepsin L	0.043	0.1909	0.2564
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.3638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.3638	1
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0045	0.0012
Giardia lamblia	Cathepsin L precursor	0.0182	0.0731	0.2506
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Giardia lamblia	Cysteine protease	0.0182	0.0731	0.2506
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0794	0.3638	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0038	0.0045	0.006
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0045	0.006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0045	0.006
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Brugia malayi	RNA binding protein	0.0064	0.0169	0.0134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.3638	1
Leishmania major	cathepsin L-like protease	0.0794	0.3638	1
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0096	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Echinococcus granulosus	allatostatin A receptor	0.0038	0.0045	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0731	0.0707
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.0036	0.001
Entamoeba histolytica	cysteine protease, putative	0.043	0.1909	0.4054
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0045	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0022
Echinococcus granulosus	7TM GPCR rhodopsin	0.0038	0.0045	0.0012
Onchocerca volvulus	Cathepsin F homolog	0.0794	0.3638	1
Leishmania major	cathepsin L-like protease	0.0794	0.3638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0182	0.0731	0.1929
Echinococcus granulosus	survival motor neuron protein 1	0.0238	0.0997	0.1297
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0038	0.0045	0.0053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.3638	1
Echinococcus granulosus	cathepsin L	0.0182	0.0731	0.0937
Echinococcus multilocularis	pyruvate kinase	0.0036	0.0036	0.0048
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0414	0.0389
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.043	0.1909	0.2528
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0182	0.0731	0.1929
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0794	0.3638	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.3638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.3638	1
Echinococcus granulosus	neuropeptide receptor	0.0038	0.0045	0.0012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.3638	1
Giardia lamblia	Cysteine protease	0.0182	0.0731	0.2506
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0182	0.0731	0.1929
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Giardia lamblia	Cathepsin B precursor	0.0182	0.0731	0.2506
Onchocerca volvulus		0.0038	0.0045	0.0053
Brugia malayi	hypothetical protein	0.0038	0.0045	0.0009
Plasmodium falciparum	serine repeat antigen 3	0.0182	0.0731	0.1929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0546	0.2459	0.6728
Giardia lamblia	Cathepsin L-like protease	0.0182	0.0731	0.2506
Onchocerca volvulus		0.0794	0.3638	1
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0045	0.006
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.3638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0182	0.0731	0.1929
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0182	0.0731	0.1929
Echinococcus granulosus	fmrfamide receptor	0.0038	0.0045	0.0012
Trypanosoma cruzi	cysteine peptidase, putative	0.0248	0.1044	0.136
Loa Loa (eye worm)	hypothetical protein	0.0794	0.3638	0.3621
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0414	0.0389
Brugia malayi	hypothetical protein	0.0038	0.0045	0.0009
Echinococcus granulosus	neuropeptide receptor A26	0.0038	0.0045	0.0012
Toxoplasma gondii	cathepsin CPC1	0.0182	0.0731	0.1929
Schistosoma mansoni	cathepsin s	0.0248	0.1044	0.136
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0045	0.0012
Giardia lamblia	Cathepsin B precursor	0.062	0.2808	1
Entamoeba histolytica	cysteine proteinase, putative	0.0794	0.3638	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0182	0.0731	0.1929
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0022
Brugia malayi	G-protein coupled receptor	0.0038	0.0045	0.0009
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.3638	1
Schistosoma mansoni	biogenic amine receptor	0.0038	0.0045	0.0012
Loa Loa (eye worm)	melatonin receptor type 1A	0.0038	0.0045	0.0019
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.3638	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.043	0.1909	0.5201
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0123	0.0097
Schistosoma mansoni	opsin-like receptor	0.0038	0.0045	0.0012
Brugia malayi	hypothetical protein	0.0038	0.0045	0.0009
Loa Loa (eye worm)	animal heme peroxidase	0.0038	0.0048	0.0022
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0038	0.0045	0.0009
Echinococcus granulosus	neuropeptide Y receptor	0.0038	0.0045	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.043	0.1909	0.5201
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0182	0.0731	0.0937
Plasmodium falciparum	serine repeat antigen 5	0.0182	0.0731	0.1929
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0038	0.0045	0.006
Brugia malayi	hypothetical protein	0.0038	0.0045	0.0009
Onchocerca volvulus		0.0546	0.2459	0.6737
Echinococcus granulosus	cathepsin L	0.043	0.1909	0.2528
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0045	0.0012
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0045	0.006
Brugia malayi	Serotonin receptor	0.0038	0.0045	0.0009
Brugia malayi	neuropeptide F receptor	0.0038	0.0045	0.0009
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0045	0.0012
Leishmania major	cathepsin L-like protease	0.0794	0.3638	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0022
Leishmania major	cathepsin L-like protease	0.0794	0.3638	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1044	0.1021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0045	0.006
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0182	0.0731	0.0707
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0292	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Onchocerca volvulus		0.0038	0.0045	0.0053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.3638	1
Echinococcus granulosus	neuropeptides capa receptor	0.0038	0.0045	0.0012
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0038	0.0045	0.0012
Leishmania major	cathepsin L-like protease	0.0794	0.3638	1
Loa Loa (eye worm)	animal heme peroxidase	0.0038	0.0048	0.0022
Schistosoma mansoni	hypothetical protein	0.0183	0.0733	0.094
Entamoeba histolytica	cysteine protease, putative	0.043	0.1909	0.4054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0045	0.006
Echinococcus multilocularis	neuropeptides capa receptor	0.0038	0.0045	0.006
Loa Loa (eye worm)	hypothetical protein	0.0546	0.2459	0.244
Giardia lamblia	Encystation-specific protease	0.0182	0.0731	0.2506
Echinococcus multilocularis	fmrfamide receptor	0.0038	0.0045	0.006
Echinococcus granulosus	cathepsin L cysteine protease	0.043	0.1909	0.2528
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0292	0.0345
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0038	0.0045	0.006
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0038	0.0045	0.006
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0182	0.0731	0.1929
Plasmodium falciparum	serine repeat antigen 9	0.0182	0.0731	0.1929
Onchocerca volvulus		0.0038	0.0045	0.0053
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0038	0.0045	0.0012
Brugia malayi	Cathepsin L-like precursor	0.0248	0.1044	0.1011
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0045	0.0012
Onchocerca volvulus		0.0038	0.0045	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0022
Echinococcus granulosus	g protein coupled receptor	0.0038	0.0045	0.0012
Entamoeba histolytica	cysteine protease, putative	0.043	0.1909	0.4054
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0169	0.0144
Brugia malayi	Papain family cysteine protease containing protein	0.043	0.1909	0.188
Entamoeba histolytica	cysteine proteinase 2	0.043	0.1909	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.3638	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Brugia malayi	G protein-coupled receptor F59B2.13	0.0038	0.0045	0.0009
Loa Loa (eye worm)	calpain family protein 1	0.0054	0.0123	0.0097
Echinococcus multilocularis	neuropeptide receptor	0.0038	0.0045	0.006
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0022
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0038	0.0045	0.0012
Echinococcus multilocularis	allatostatin A receptor	0.0038	0.0045	0.006
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0045	0.0012
Plasmodium falciparum	cysteine proteinase falcipain 1	0.043	0.1909	0.5201
Brugia malayi	Animal haem peroxidase family protein	0.0038	0.0048	0.0012
Giardia lamblia	Cathepsin L precursor	0.0182	0.0731	0.2506
Loa Loa (eye worm)	calpain family protein 1	0.004	0.0055	0.0029
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0169	0.018
Brugia malayi	Cathepsin L-like precursor	0.0794	0.3638	0.3615
Giardia lamblia	Cathepsin B precursor	0.062	0.2808	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0794	0.3638	0.486
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0045	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Giardia lamblia	Hypothetical protein	0.0182	0.0731	0.2506
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0546	0.2459	0.2432
Trypanosoma cruzi	major cysteine proteinase, putative	0.0182	0.0731	0.0937
Echinococcus multilocularis	sex peptide receptor	0.0038	0.0045	0.006
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.3638	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1597	0.7448	1
Echinococcus granulosus	somatostatin receptor	0.0038	0.0045	0.0012
Onchocerca volvulus		0.0049	0.0096	0.0195
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0057	0.0134	0.0133
Onchocerca volvulus		0.0038	0.0048	0.0062
Brugia malayi	hypothetical protein	0.0038	0.0045	0.0009
Trypanosoma cruzi	cysteine proteinase, putative	0.043	0.1909	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Brugia malayi	hypothetical protein	0.0038	0.0045	0.0009
Loa Loa (eye worm)	hypothetical protein	0.004	0.0055	0.0029
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0045	0.0012
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0038	0.0045	0.006
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.3638	1
Brugia malayi	hypothetical protein	0.0038	0.0045	0.0009
Schistosoma mansoni	peroxidasin	0.0038	0.0048	0.0016
Schistosoma mansoni	neuropeptide F-like receptor	0.0038	0.0045	0.0012
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0038	0.0045	0.0009
Giardia lamblia	Cathepsin B precursor	0.0182	0.0731	0.2506
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0038	0.0045	0.006
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0182	0.0731	0.0937
Onchocerca volvulus		0.0038	0.0045	0.0053
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0292	0.0345
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0182	0.0731	0.1929
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0182	0.0731	0.1929
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0038	0.0045	0.006
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.0036	0.0029
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0182	0.0731	0.0937
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0794	0.3638	0.486
Brugia malayi	fibroinase precursor	0.0182	0.0731	0.0697
Echinococcus multilocularis	somatostatin receptor	0.0038	0.0045	0.006
Giardia lamblia	Cathepsin L precursor	0.0182	0.0731	0.2506
Echinococcus granulosus	biogenic amine 5HT receptor	0.0038	0.0045	0.0012
Brugia malayi	Dopamine receptor	0.0038	0.0045	0.0009
Toxoplasma gondii	cathepsin B	0.062	0.2808	0.7697
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0094	0.0068
Echinococcus multilocularis	G protein coupled receptor 139	0.0038	0.0045	0.006
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.0292	0.0267
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0045	0.0012
Onchocerca volvulus	Peroxidase homolog	0.0038	0.0048	0.0062
Brugia malayi	ORL1-like opioid receptor	0.0038	0.0045	0.0009
Onchocerca volvulus		0.0794	0.3638	1
Brugia malayi	hypothetical protein	0.0038	0.0045	0.0009
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0045	0.0012
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0038	0.0045	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Brugia malayi	hypothetical protein	0.0038	0.0048	0.0012
Plasmodium falciparum	serine repeat antigen 7	0.0182	0.0731	0.1929
Trichomonas vaginalis	conserved hypothetical protein	0.0182	0.0731	0.1929
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0057	0.0134	0.018
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0045	0.0012
Brugia malayi	G-protein coupled receptor	0.0038	0.0045	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Brugia malayi	larval opioid receptor	0.0038	0.0045	0.0009
Loa Loa (eye worm)	G-protein coupled receptor	0.0038	0.0045	0.0019
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0292	0.0345
Brugia malayi	Animal haem peroxidase family protein	0.0038	0.0048	0.0012
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0045	0.0012
Trypanosoma cruzi	cysteine peptidase, putative	0.043	0.1909	0.2528
Giardia lamblia	Cathepsin L-like protease	0.0182	0.0731	0.2506
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0045	0.0012
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0038	0.0045	0.006
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0182	0.0731	0.0697
Loa Loa (eye worm)	animal heme peroxidase	0.0038	0.0048	0.0022
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0169	0.018
Echinococcus multilocularis	geminin	0.0183	0.0733	0.0984
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0182	0.0731	0.1929
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0038	0.0045	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Entamoeba histolytica	cysteine proteinase, putative	0.043	0.1909	0.4054
Echinococcus granulosus	neuropeptide FF receptor 2	0.0038	0.0045	0.0012
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.3638	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0045	0.0012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0292	0.0345
Loa Loa (eye worm)	blistered cuticle protein 3	0.0038	0.0048	0.0022
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.0036	0.0029
Echinococcus multilocularis	pyruvate kinase	0.0036	0.0036	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.3638	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0182	0.0731	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0022
Echinococcus multilocularis	cathepsin L cysteine protease	0.0794	0.3638	0.4884
Echinococcus multilocularis	cathepsin L cysteine protease	0.0794	0.3638	0.4884
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0794	0.3638	0.486
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0038	0.0045	0.0053
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1597	0.7448	1
Onchocerca volvulus		0.0038	0.0045	0.0053
Schistosoma mansoni	opsin-like receptor	0.0038	0.0045	0.0012
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0038	0.0045	0.0012
Schistosoma mansoni	hypothetical protein	0.0183	0.0733	0.094
Brugia malayi	Papain family cysteine protease containing protein	0.043	0.1909	0.188
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0182	0.0731	0.1929
Plasmodium falciparum	serine repeat antigen 8	0.0182	0.0731	0.1929
Brugia malayi	Melatonin receptor type 1A	0.0038	0.0045	0.0009
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0045	0.0012
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0045	0.006
Brugia malayi	hypothetical protein	0.0038	0.0045	0.0009
Entamoeba histolytica	cysteine proteinase, putative	0.043	0.1909	0.4054
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0045	0.006
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0038	0.0045	0.0019
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0038	0.0045	0.006
Schistosoma mansoni	histamine h1 receptor	0.0038	0.0045	0.0012
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0182	0.0731	0.1929
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.062	0.2808	0.7697
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0038	0.0045	0.0012
Onchocerca volvulus	Pyruvate kinase homolog	0.0036	0.0036	0.0029
Brugia malayi	Cathepsin L-like precursor	0.0546	0.2459	0.2432
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.043	0.1909	0.2528
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0038	0.0045	0.006
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0248	0.1044	0.1011
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0038	0.0045	0.0012
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0045	0.0012
Schistosoma mansoni	amine GPCR	0.0038	0.0045	0.0012
Schistosoma mansoni	cathepsin F (C01 family)	0.0794	0.3638	0.486
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.3638	1
Brugia malayi	Papain family cysteine protease containing protein	0.0182	0.0731	0.0697
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0169	0.0134
Onchocerca volvulus		0.0038	0.0045	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0731	0.0707
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0038	0.0045	0.0012
Brugia malayi	Papain family cysteine protease containing protein	0.0182	0.0731	0.0697
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0045	0.0019
Plasmodium falciparum	serine repeat antigen 2	0.0182	0.0731	0.1929
Echinococcus granulosus	microtubule associated protein 2	0.0744	0.3397	0.4535
Plasmodium vivax	unspecified product	0.0248	0.1044	0.2798
Echinococcus multilocularis	microtubule associated protein 2	0.0744	0.3397	0.4561
Brugia malayi	Animal haem peroxidase family protein	0.0038	0.0048	0.0012
Giardia lamblia	Cathepsin B precursor	0.0182	0.0731	0.2506
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0038	0.0045	0.006
Toxoplasma gondii	cathepsin CPC2	0.0182	0.0731	0.1929
Brugia malayi	Cathepsin L-like precursor	0.0794	0.3638	0.3615
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0045	0.0012
Plasmodium vivax	vivapain-1	0.043	0.1909	0.5201
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0182	0.0731	0.1929
Trypanosoma cruzi	cruzipain precursor, putative	0.0248	0.1044	0.136
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0038	0.0045	0.006
Giardia lamblia	Cathepsin L precursor	0.0182	0.0731	0.2506
Schistosoma mansoni	hypothetical protein	0.0049	0.0096	0.0081
Schistosoma mansoni	hypothetical protein	0.0038	0.0045	0.0012
Schistosoma mansoni	cathepsin S (C01 family)	0.0182	0.0731	0.0937
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0045	0.0012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.3638	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0045	0.0012
Echinococcus granulosus	tm gpcr rhodopsin	0.0038	0.0045	0.0012
Plasmodium vivax	vivapain-3	0.043	0.1909	0.5201
Giardia lamblia	Cathepsin L precursor	0.0182	0.0731	0.2506
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0182	0.0731	0.1929
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.062	0.2808	0.7697
Schistosoma mansoni	adenoreceptor	0.0038	0.0045	0.0012
Echinococcus multilocularis	survival motor neuron protein 1	0.0238	0.0997	0.1339
Echinococcus granulosus	calpain A	0.0057	0.0134	0.0133
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.043	0.1909	0.5201
Brugia malayi	cathepsin F-like cysteine proteinase	0.0248	0.1044	0.1011
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0182	0.0731	0.2506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0182	0.0731	0.1929
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0096	0.006
Brugia malayi	putative neuropeptide receptor NPR1	0.0038	0.0045	0.0009
Brugia malayi	MH2 domain containing protein	0.0116	0.0414	0.0379
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0057	0.0134	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0022
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.043	0.1909	0.2528
Echinococcus multilocularis	cathepsin b	0.1597	0.7448	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0038	0.0045	0.0012
Onchocerca volvulus		0.0038	0.0045	0.0053
Brugia malayi	Dopamine receptor protein 2	0.0038	0.0045	0.0009
Brugia malayi	Peroxidasin	0.0038	0.0048	0.0012
Echinococcus multilocularis	cathepsin b	0.1597	0.7448	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0182	0.0731	0.1929
Brugia malayi	Cathepsin L-like precursor	0.0546	0.2459	0.2432
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.0036	0.001
Plasmodium vivax	unspecified product	0.043	0.1909	0.5201
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0794	0.3638	0.4884
Loa Loa (eye worm)	cathepsin B	0.062	0.2808	0.279
Brugia malayi	cathepsin L-like cysteine proteinase	0.0182	0.0731	0.0697
Echinococcus multilocularis	calpain A	0.0057	0.0134	0.018
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Schistosoma mansoni	amine GPCR	0.0038	0.0045	0.0012
Onchocerca volvulus	Cathepsin L homolog	0.0794	0.3638	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0038	0.0045	0.0019
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0169	0.0227
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0045	0.0012
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0038	0.0045	0.0019
Loa Loa (eye worm)	neuropeptide F receptor	0.0038	0.0045	0.0019
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0182	0.0731	0.0937
Brugia malayi	cathepsin B-like cysteine proteinase	0.1597	0.7448	0.7439
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Echinococcus granulosus	rhodopsin orphan GPCR	0.0038	0.0045	0.0012
Brugia malayi	TAR-binding protein	0.0064	0.0169	0.0134
Onchocerca volvulus	Chorion peroxidase homolog	0.0038	0.0048	0.0062
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0038	0.0045	0.0012
Onchocerca volvulus		0.0038	0.0045	0.0053
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0038	0.0045	0.0012
Schistosoma mansoni	peroxidasin	0.0038	0.0048	0.0016
Entamoeba histolytica	cysteine protease, putative	0.043	0.1909	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0794	0.3638	0.3615
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0022
Echinococcus multilocularis	neuropeptide Y receptor	0.0038	0.0045	0.006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0794	0.3638	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0182	0.0731	0.1929
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Brugia malayi	Serotonin receptor	0.0038	0.0045	0.0009
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.3638	1
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0182	0.0731	0.1929
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0182	0.0731	0.1929
Echinococcus granulosus	peroxidasin	0.0038	0.0048	0.0016
Brugia malayi	cathepsin L precursor	0.0182	0.0731	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0238	0.0997	0.0974
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.3638	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0794	0.3638	1
Entamoeba histolytica	cysteine proteinase, putative	0.0794	0.3638	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0794	0.3638	0.486
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0038	0.0045	0.0012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.3638	1
Onchocerca volvulus		0.0794	0.3638	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0038	0.0045	0.0012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0546	0.2459	0.6728
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0022
Echinococcus multilocularis	g protein coupled receptor	0.0038	0.0045	0.006
Plasmodium vivax	unspecified product	0.0182	0.0731	0.1929
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0038	0.0045	0.0012
Onchocerca volvulus		0.0794	0.3638	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0022
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0182	0.0731	0.0937
Schistosoma mansoni	hypothetical protein	0.0038	0.0045	0.0012
Echinococcus multilocularis	serotonin receptor	0.0038	0.0045	0.006
Trypanosoma cruzi	major cysteine proteinase, putative	0.0182	0.0731	0.0937
Echinococcus granulosus	orexin receptor type 2	0.0038	0.0045	0.0012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0182	0.0731	0.1929
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0546	0.2459	0.327
Brugia malayi	cathepsin L-like precursor	0.0546	0.2459	0.2432
Giardia lamblia	Cathepsin B precursor	0.0182	0.0731	0.2506
Echinococcus multilocularis	peroxidasin	0.0038	0.0048	0.0064
Brugia malayi	RE15519p	0.0038	0.0045	0.0009
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0182	0.0731	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0022
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0038	0.0045	0.006
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0785	0.3593	0.4824
Schistosoma mansoni	neuropeptide f receptor 76f	0.0038	0.0045	0.0012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.3638	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0794	0.3638	0.3621
Echinococcus multilocularis	neuropeptide s receptor	0.0038	0.0045	0.006
Entamoeba histolytica	cysteine protease, putative	0.043	0.1909	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0794	0.3638	0.3615
Schistosoma mansoni	cathepsin B (C01 family)	0.0182	0.0731	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0182	0.0731	0.2506
Giardia lamblia	Cysteine protease	0.0182	0.0731	0.2506
Entamoeba histolytica	cysteine proteinase, putative	0.043	0.1909	0.4054
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0182	0.0731	0.2506
Schistosoma mansoni	amine GPCR	0.0038	0.0045	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0022
Loa Loa (eye worm)	pyruvate kinase	0.0036	0.0036	0.001
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0182	0.0731	0.0937
Echinococcus granulosus	cysteine protease	0.043	0.1909	0.2528
Brugia malayi	calpain family protein 1	0.0054	0.0123	0.0087
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1597	0.7448	1
Brugia malayi	calpain family protein 1	0.0054	0.0123	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0182	0.0731	0.1929
Schistosoma mansoni	neuropeptide receptor	0.0038	0.0045	0.0012
Loa Loa (eye worm)	hypothetical protein	0.2134	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0182	0.0731	0.1929
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0048	0.0022
Trypanosoma cruzi	cysteine protease, putative	0.043	0.1909	0.2528
Onchocerca volvulus		0.0038	0.0045	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0182	0.0731	0.1929
Echinococcus granulosus	hypothetical protein	0.0038	0.0045	0.0012
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0054	0.0123	0.0117
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0038	0.0045	0.0012
Loa Loa (eye worm)	fibroinase	0.0794	0.3638	0.3621
Giardia lamblia	Cathepsin L precursor	0.0182	0.0731	0.2506
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0036	0.0036	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.3638	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0038	0.0045	0.0019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.043	0.1909	0.5201
Entamoeba histolytica	cysteine proteinase, putative	0.0546	0.2459	0.5946
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0038	0.0045	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0045	0.0019

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.5 uM	Compound was evaluated for half-maximal inhibition of binding of [3H]-Oxytocin to Oxytocin receptor in rat uterine tissue	ChEMBL.	1331449
IC50 (binding)	= 4.5 uM	Compound was evaluated for half-maximal inhibition of binding of [3H]-Oxytocin to Oxytocin receptor in rat uterine tissue	ChEMBL.	1331449
IC50 (binding)	> 100 uM	Compound was evaluated for half-maximal inhibition of binding of [3H]-Vasopressin toVasopressin V1 receptor in rat liver	ChEMBL.	1331449
IC50 (binding)	> 100 uM	Compound was evaluated for half-maximal inhibition of binding of [3H]-Vasopressin to Vasopressin V2 receptor	ChEMBL.	1331449
IC50 (binding)	> 100 uM	Compound was evaluated for half-maximal inhibition of binding of [3H]-Vasopressin toVasopressin V1 receptor in rat liver	ChEMBL.	1331449
IC50 (binding)	> 100 uM	Compound was evaluated for half-maximal inhibition of binding of [3H]-Vasopressin to Vasopressin V2 receptor	ChEMBL.	1331449

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL339698

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 220515