Detailed information for compound 226776

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 303.677 | Formula: C10H11ClFN5O3
  • H donors: 3 H acceptors: 5 LogP: -0.2 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1OC([C@@H]([C@H]1O)Cl)n1cnc2c1nc(F)nc2N
  • InChi: 1S/C10H11ClFN5O3/c11-4-6(19)3(1-18)20-9(4)17-2-14-5-7(13)15-10(12)16-8(5)17/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4-,6+,9?/m1/s1
  • InChiKey: VDDCABUBVCCVDW-AWYOIGHKSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphofructokinase, putative 0.0018 0.002 0.0686
Loa Loa (eye worm) 6-phosphofructokinase 0.0068 0.0104 0.0701
Schistosoma mansoni ap endonuclease 0.0012 0.0009 0.0011
Brugia malayi hypothetical protein 0.0012 0.0009 0.0061
Brugia malayi YY1-associated factor 2 0.0013 0.0011 0.0071
Echinococcus multilocularis microtubule associated protein 2 0.041 0.0682 0.0682
Onchocerca volvulus 0.0362 0.06 1
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0013 0.0011 0.0161
Brugia malayi 6-phosphofructokinase 0.0068 0.0104 0.0701
Toxoplasma gondii fructose-bisphospatase II 0.0238 0.0392 1
Echinococcus granulosus zinc finger protein Ran binding 0.0013 0.0011 0.0011
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0013 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0013 0.001 0.0067
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0009 0.0004 0.0028
Echinococcus multilocularis glycoprotein Antigen 5 0.0021 0.0024 0.0024
Leishmania major 0.0238 0.0392 0.6519
Brugia malayi hypothetical protein 0.0242 0.0397 0.2678
Trypanosoma cruzi hypothetical protein, conserved 0.0151 0.0245 0.4068
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0011 0.0161
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0012 0.0009 0.0297
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0024 0.003
Echinococcus multilocularis axis inhibition protein axin 0.0012 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0067
Loa Loa (eye worm) hypothetical protein 0.0362 0.06 0.4044
Entamoeba histolytica hypothetical protein 0.0362 0.06 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0013 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0106 0.0169 0.0203
Echinococcus granulosus ring and YY1 binding protein 0.0013 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0706 0.1181 0.1424
Echinococcus granulosus dnaJ subfamily B 0.0243 0.04 0.04
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0013 0.0011 0.0048
Trichomonas vaginalis phosphofructokinase, putative 0.0068 0.0104 0.3714
Echinococcus multilocularis enteropeptidase 0.0021 0.0024 0.0024
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0012 0.0009 0.0061
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0012 0.0009 0.0009
Schistosoma mansoni thyroid hormone receptor 0.0091 0.0142 0.0171
Echinococcus granulosus microtubule associated protein 2 0.041 0.0682 0.0682
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0009 0.0011
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0362 0.06 0.4044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0013 0.001 0.0067
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0013 0.001 0.001
Echinococcus multilocularis tissue type plasminogen activator 0.0151 0.0245 0.0245
Echinococcus granulosus axis inhibition protein axin 0.0012 0.0009 0.0009
Brugia malayi intermediate filament protein 0.0017 0.0017 0.0117
Loa Loa (eye worm) RecQ helicase 0.0013 0.0011 0.0077
Echinococcus granulosus glutamate receptor 2 0.0541 0.0903 0.0903
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0706 0.1181 0.1181
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0012 0.0009 0.0011
Brugia malayi Receptor family ligand binding region containing protein 0.0362 0.06 0.4044
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0068 0.0104 0.5
Brugia malayi Guanylyl cyclase protein 23 0.0362 0.06 0.4044
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0024 0.003
Brugia malayi phosphofructokinase 0.0068 0.0104 0.0701
Brugia malayi SWIB/MDM2 domain containing protein 0.0036 0.005 0.0337
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0362 0.06 0.4044
Loa Loa (eye worm) brahma associated protein 0.0036 0.005 0.0337
Loa Loa (eye worm) hypothetical protein 0.0362 0.06 0.4044
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0013 0.0011 0.0071
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0036 0.005 0.005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0013 0.001 0.0067
Echinococcus multilocularis lipoxygenase domain containing protein 0.0242 0.0397 0.0397
Brugia malayi cytoplasmic intermediate filament protein 0.0009 0.0004 0.0028
Schistosoma mansoni hypothetical protein 0.0021 0.0024 0.003
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0013 0.0011 0.0247
Schistosoma mansoni hypothetical protein 0.0021 0.0024 0.003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0091 0.0142 0.0142
Schistosoma mansoni glutamate receptor AMPA 0.0885 0.1484 0.1789
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0013 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0023 0.0027 0.0435
Schistosoma mansoni axis inhibition protein axin 0.0012 0.0009 0.0011
Schistosoma mansoni microtubule-associated protein tau 0.041 0.0682 0.0822
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0008 0.0003 0.0003
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0018 0.002 0.0413
Schistosoma mansoni retinoic acid receptor RXR 0.0013 0.001 0.0012
Schistosoma mansoni zinc finger protein 0.0013 0.0011 0.0013
Schistosoma mansoni apoptosis regulator bax 0.0306 0.0506 0.061
Echinococcus granulosus Zinc finger RanBP2 type 0.0013 0.0011 0.0011
Onchocerca volvulus 0.0017 0.0017 0.0125
Echinococcus multilocularis receptor type guanylyl cyclase 0.0362 0.06 0.06
Brugia malayi 6-phosphofructokinase 0.0068 0.0104 0.0701
Trypanosoma brucei cytochrome P450, putative 0.001 0.0005 0.0103
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0005 0.0067
Brugia malayi hypothetical protein 0.0362 0.06 0.4044
Echinococcus granulosus atrial natriuretic peptide receptor 0.0362 0.06 0.06
Brugia malayi hypothetical protein 0.0012 0.0009 0.0061
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0012 0.0009 0.0011
Onchocerca volvulus 0.0151 0.0245 0.3977
Echinococcus granulosus Mastin 0.0021 0.0024 0.0024
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0238 0.0392 1
Brugia malayi ecdysteroid receptor 0.0013 0.001 0.0067
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0089 0.0139 0.2297
Plasmodium vivax hypothetical protein, conserved 0.0036 0.005 0.1166
Entamoeba histolytica phosphofructokinase, putative 0.0068 0.0104 0.1722
Echinococcus granulosus glutamate receptor 2 0.1247 0.2095 0.2095
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0362 0.06 0.4044
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0007 0.0008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0032 0.0043 0.102
Loa Loa (eye worm) RGS-3 protein 0.0012 0.0009 0.0061
Brugia malayi Steroid receptor seven-up type 2 0.0013 0.001 0.0067
Entamoeba histolytica hypothetical protein 0.0012 0.0009 0.0138
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0061
Chlamydia trachomatis glutamine binding protein 0.1552 0.261 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0362 0.06 0.06
Echinococcus multilocularis RUN 0.0242 0.0397 0.0397
Brugia malayi Trypsin family protein 0.0021 0.0024 0.0165
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0024 0.003
Echinococcus multilocularis expressed protein 0.0234 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0362 0.06 0.4044
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0012 0.0009 0.0061
Loa Loa (eye worm) TK/ROR protein kinase 0.0151 0.0245 0.1649
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.005 0.1766
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0012 0.0009 0.0061
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.1247 0.2095 0.2095
Entamoeba histolytica hypothetical protein 0.0023 0.0027 0.0435
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0706 0.1181 0.1181
Schistosoma mansoni coup transcription factor 0.0013 0.001 0.0012
Echinococcus granulosus tyrosine kinase 0.0362 0.06 0.06
Schistosoma mansoni hypothetical protein 0.0151 0.0245 0.0295
Schistosoma mansoni tyrosine kinase 0.0362 0.06 0.0724
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0024 0.003
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0362 0.06 1
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0306 0.0506 0.3409
Entamoeba histolytica hypothetical protein 0.0012 0.0009 0.0138
Entamoeba histolytica phosphofructokinase, putative 0.0068 0.0104 0.1722
Brugia malayi Trypsin family protein 0.0021 0.0024 0.0165
Schistosoma mansoni glutamate receptor kainate 0.0885 0.1484 0.1789
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0013 0.0011 0.0011
Loa Loa (eye worm) PXA domain-containing protein 0.0012 0.0009 0.0061
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.1552 0.261 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0013 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0362 0.06 0.4044
Echinococcus granulosus lipoxygenase domain containing protein 0.0242 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0067
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1247 0.2095 0.2095
Trichomonas vaginalis ap endonuclease, putative 0.0012 0.0009 0.0283
Leishmania major ATP-dependent phosphofructokinase 0.0068 0.0104 0.1722
Trichomonas vaginalis glutaminase, putative 0.0172 0.0279 1
Schistosoma mansoni regulator of G protein signaling 0.0012 0.0009 0.0011
Echinococcus granulosus beta-adrenergic receptor kinase 0.0012 0.0009 0.0009
Brugia malayi Doublecortin family protein 0.0242 0.0397 0.2678
Leishmania major hypothetical protein, conserved 0.0013 0.0011 0.0161
Schistosoma mansoni TRABID protein (C64 family) 0.0013 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0362 0.06 0.4044
Toxoplasma gondii phosphofructokinase PFKII 0.0018 0.002 0.0413
Schistosoma mansoni hypothetical protein 0.0036 0.005 0.006
Loa Loa (eye worm) RGC/RGC protein kinase 0.0362 0.06 0.4044
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0036 0.005 0.1166
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0021 0.0024 0.0024
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.1552 0.261 1
Leishmania major extracellular receptor, putative 0.0362 0.06 1
Echinococcus granulosus 6 phosphofructokinase 0.0068 0.0104 0.0104
Schistosoma mansoni protein kinase 0.0362 0.06 0.0724
Schistosoma mansoni lipoxygenase 0.0677 0.1133 0.1366
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0061
Brugia malayi Protein kinase domain containing protein 0.0151 0.0245 0.1649
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0009 0.0118
Echinococcus multilocularis FTZ F1 alpha 0.0013 0.001 0.001
Mycobacterium ulcerans glutaminase 0.0172 0.0279 0.1051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0013 0.001 0.0067
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0018 0.002 1
Brugia malayi Glutamate receptor 1 precursor 0.0885 0.1484 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0046
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0024 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0023 0.0027 0.0027
Trypanosoma cruzi extracellular receptor, putative 0.0362 0.06 1
Loa Loa (eye worm) steroid hormone receptor 0.0013 0.001 0.0067
Echinococcus multilocularis tyrosine kinase 0.0362 0.06 0.06
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0297
Trichomonas vaginalis phosphofructokinase, putative 0.0018 0.002 0.0686
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0018 0.002 0.0686
Loa Loa (eye worm) hypothetical protein 0.0362 0.06 0.4044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0013 0.001 0.0067
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0089 0.0139 0.3474
Plasmodium vivax multidomain scavenger receptor, putative 0.0242 0.0397 1
Toxoplasma gondii fructose-bisphospatase I 0.0089 0.0139 0.3474
Loa Loa (eye worm) trypsin family protein 0.0021 0.0024 0.0165
Schistosoma mansoni glutamate receptor kainate 0.0885 0.1484 0.1789
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0018 0.002 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0013 0.001 0.0067
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1247 0.2095 0.2095
Onchocerca volvulus 0.0242 0.0397 0.6564
Onchocerca volvulus 0.0021 0.0024 0.0245
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0013 0.0011 0.0161
Brugia malayi Cytochrome P450 family protein 0.001 0.0005 0.0033
Echinococcus granulosus glutamate receptor NMDA 0.3669 0.6186 0.6186
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0061
Trichomonas vaginalis phosphofructokinase, putative 0.0018 0.002 0.0686
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0013 0.001 0.0012
Loa Loa (eye worm) 6-phosphofructokinase 0.0068 0.0104 0.0701
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.1247 0.2095 0.2095
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.1482 0.2493 0.2493
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0068 0.0104 0.0367
Echinococcus granulosus lipoxygenase domain containing protein 0.0242 0.0397 0.0397
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0362 0.06 0.4044
Echinococcus multilocularis transmembrane protease serine 3 0.0021 0.0024 0.0024
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0013 0.0011 0.0161
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0013 0.001 0.0012
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0362 0.06 0.4044
Loa Loa (eye worm) RGC/RGC protein kinase 0.0362 0.06 0.4044
Brugia malayi Glutamate receptor 2 precursor 0.0885 0.1484 1
Echinococcus granulosus regulator of G protein signaling 7 0.0012 0.0009 0.0009
Echinococcus granulosus lamin dm0 0.0017 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0013 0.001 0.0067
Brugia malayi hypothetical protein 0.0023 0.0027 0.0182
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.001 0.001
Schistosoma mansoni ap endonuclease 0.0012 0.0009 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0013 0.001 0.0067
Echinococcus multilocularis glutamate receptor 2 0.0541 0.0903 0.0903
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0068 0.0104 0.0367
Echinococcus granulosus RUN 0.0242 0.0397 0.0397
Schistosoma mansoni hypothetical protein 0.0036 0.005 0.006
Leishmania major hypothetical protein, conserved 0.0013 0.0011 0.0161
Echinococcus multilocularis Polycystic kidney disease protein 0.0242 0.0397 0.0397
Loa Loa (eye worm) phosphofructokinase 0.0068 0.0104 0.0701
Brugia malayi Nuclear hormone receptor-like 1 0.0161 0.026 0.1754
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0013 0.0011 0.0161
Schistosoma mansoni glutamate receptor AMPA 0.0885 0.1484 0.1789
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0036 0.005 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0011 0.0161
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0068 0.0104 0.2642
Schistosoma mansoni steroid hormone receptor ad4bp 0.0013 0.001 0.0012
Schistosoma mansoni hypothetical protein 0.0242 0.0397 0.0479
Echinococcus granulosus glutamate NMDA receptor subunit 0.1025 0.172 0.172
Entamoeba histolytica hypothetical protein 0.0012 0.0009 0.0138
Trichomonas vaginalis phosphofructokinase, putative 0.0068 0.0104 0.3714
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0061
Brugia malayi Regulator of G protein signaling domain containing protein 0.0012 0.0009 0.0061
Mycobacterium ulcerans hypothetical protein 0.0021 0.0024 0.0075
Trichomonas vaginalis phosphofructokinase, putative 0.0068 0.0104 0.3714
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0013 0.001 0.0067
Echinococcus granulosus enteropeptidase 0.0021 0.0024 0.0024
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0306 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0067
Brugia malayi hypothetical protein 0.0021 0.0024 0.0165
Schistosoma mansoni 6-phosphofructokinase 0.0068 0.0104 0.0126
Brugia malayi Metabotropic glutamate receptor precursor. 0.0362 0.06 0.4044
Echinococcus multilocularis ecdysone induced protein 78C 0.0013 0.001 0.001
Brugia malayi photoreceptor-specific nuclear receptor 0.0013 0.001 0.0067
Onchocerca volvulus 0.0242 0.0397 0.6564
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0706 0.1181 0.1181
Toxoplasma gondii 6-phosphofructokinase 0.0018 0.002 0.0413
Onchocerca volvulus 0.0013 0.0011 0.0009
Loa Loa (eye worm) apoptosis regulator protein 0.0306 0.0506 0.3409
Echinococcus multilocularis bloom syndrome protein 0.0013 0.0011 0.0011
Echinococcus granulosus nmda type glutamate receptor 0.4031 0.6798 0.6798
Schistosoma mansoni lamin 0.0017 0.0017 0.0021
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0012 0.0009 0.0015
Leishmania major hypothetical protein, conserved 0.0013 0.0011 0.0161
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0061
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0018 0.002 0.0318
Brugia malayi regulator of G-protein signaling rgs-7 0.0012 0.0009 0.0061
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0023 0.0027 0.0027
Echinococcus granulosus metabotropic glutamate receptor 5 0.0362 0.06 0.06
Echinococcus multilocularis 6 phosphofructokinase 0.0068 0.0104 0.0104
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0013 0.0011 0.0071
Echinococcus multilocularis regulator of G protein signaling 3 0.0012 0.0009 0.0009
Echinococcus granulosus tumor protein p63 0.0173 0.028 0.028
Onchocerca volvulus 0.0013 0.0011 0.0009
Leishmania major hypothetical protein, conserved 0.0013 0.0011 0.0161
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0165
Onchocerca volvulus 0.0013 0.0011 0.0009
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0013 0.0011 0.0071
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0071
Brugia malayi Trypsin-like protease protein 5 0.0021 0.0024 0.0165
Echinococcus multilocularis zinc finger protein Ran binding 0.0013 0.0011 0.0011
Echinococcus multilocularis tumor protein p63 0.0173 0.028 0.028
Echinococcus multilocularis glutamate receptor 2 0.1247 0.2095 0.2095
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0071
Leishmania major hypothetical protein, conserved 0.0013 0.0011 0.0161
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0677 0.1133 0.1133
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0114
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.1552 0.261 1
Loa Loa (eye worm) doublecortin family protein 0.0242 0.0397 0.2678
Loa Loa (eye worm) RGC/RGC protein kinase 0.0362 0.06 0.4044
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0013 0.0011 0.0161
Schistosoma mansoni z-protein (S1r protein) 0.0012 0.0009 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0297
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0013 0.001 0.0067
Echinococcus multilocularis geminin 0.0106 0.0169 0.0169
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0089 0.0139 0.2297
Brugia malayi A-kinase anchor protein 10, precursor 0.0012 0.0009 0.0061
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0024 0.003
Schistosoma mansoni polycystin 1-related 0.0242 0.0397 0.0479
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.1025 0.172 0.172
Loa Loa (eye worm) intermediate filament protein 0.0017 0.0017 0.0117
Brugia malayi PXA domain containing protein 0.0012 0.0009 0.0061
Echinococcus granulosus SWI:SNF matrix associated 0.0036 0.005 0.005
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0238 0.0392 0.0392
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1247 0.2095 0.2095
Echinococcus granulosus regulator of G protein signaling 3 0.0012 0.0009 0.0009
Schistosoma mansoni rab6-interacting 0.0242 0.0397 0.0479
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0011 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0297
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0238 0.0392 0.6519
Onchocerca volvulus 0.0025 0.0031 0.0364
Schistosoma mansoni cpg binding protein 0.0017 0.0018 0.0021
Echinococcus granulosus glycoprotein Antigen 5 0.0021 0.0024 0.0024
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0238 0.0392 0.2638
Echinococcus multilocularis nmda type glutamate receptor 0.5926 1 1
Chlamydia trachomatis DNA topoisomerase I 0.0036 0.005 0.0116
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0024 0.003
Schistosoma mansoni glutamate receptor NMDA 0.4916 0.8293 1
Echinococcus multilocularis lamin 0.0017 0.0017 0.0017
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0012 0.0009 0.0131
Trichomonas vaginalis ap endonuclease, putative 0.0012 0.0009 0.0283
Echinococcus multilocularis SWI:SNF matrix associated 0.0036 0.005 0.005
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0013 0.0011 0.0011
Brugia malayi Kringle domain containing protein 0.0151 0.0245 0.1649
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0067
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0024 0.003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0242 0.0397 0.0397
Schistosoma mansoni lipoxygenase 0.0242 0.0397 0.0479
Chlamydia trachomatis SWIB complex protein 0.0036 0.005 0.0116
Brugia malayi nuclear hormone receptor 0.0013 0.001 0.0067
Schistosoma mansoni glutamate receptor kainate 0.0885 0.1484 0.1789
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.1482 0.2493 0.2493
Echinococcus multilocularis regulator of G protein signaling 0.0012 0.0009 0.0009
Echinococcus multilocularis Regulator of G protein signaling 20 0.0012 0.0009 0.0009
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0013 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0306 0.0506 0.061
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0155 0.025 0.1686
Echinococcus granulosus metabotropic glutamate receptor 2 0.0362 0.06 0.06
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0036 0.005 0.1188
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0036 0.005 0.0337
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0008 0.0003 0.0003
Onchocerca volvulus 0.0021 0.0024 0.0245
Onchocerca volvulus 0.0021 0.0024 0.0245
Loa Loa (eye worm) glutamate receptor 2 0.0885 0.1484 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0078 0.0121 0.0121
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0306 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0362 0.06 0.4044
Schistosoma mansoni metabotropic glutamate receptor 0.0362 0.06 0.0724
Echinococcus granulosus glutamate receptor subunit protein glur 0.0706 0.1181 0.1181
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0362 0.06 0.06
Schistosoma mansoni fusion 0.0013 0.0011 0.0013
Loa Loa (eye worm) CYP4Cod1 0.001 0.0005 0.0033
Loa Loa (eye worm) hypothetical protein 0.0242 0.0397 0.2678
Onchocerca volvulus 0.0013 0.0011 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0024 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0165
Brugia malayi brahma associated protein 60 kDa 0.0036 0.005 0.0337
Echinococcus multilocularis ring and YY1 binding protein 0.0013 0.0011 0.0011
Echinococcus multilocularis axis inhibition protein axin 0.0012 0.0009 0.0009
Schistosoma mansoni axis inhibition protein axin 0.0012 0.0009 0.0011
Echinococcus granulosus regulator of G protein signaling 7 0.0012 0.0009 0.0009
Brugia malayi Receptor family ligand binding region containing protein 0.0362 0.06 0.4044
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0165
Echinococcus multilocularis lamin dm0 0.0017 0.0017 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0018 0.002 0.0686
Trypanosoma cruzi WLM domain containing protein, putative 0.0013 0.0011 0.0161
Brugia malayi metabotropic glutamate receptor type 2 0.0362 0.06 0.4044
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0024 0.003
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0013 0.0011 0.0071
Echinococcus multilocularis glutamate receptor NMDA 0.3669 0.6186 0.6186
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0013 0.001 0.0067
Schistosoma mansoni regulator of G protein signaling 0.0012 0.0009 0.0011
Schistosoma mansoni ATP-binding cassette transporter 0.0885 0.1484 0.1789
Echinococcus granulosus expressed protein 0.0234 0.0385 0.0385
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.001 0.001
Trypanosoma cruzi cytochrome P450, putative 0.001 0.0005 0.0067
Schistosoma mansoni cpg binding protein 0.0018 0.0019 0.0023
Schistosoma mansoni cellular tumor antigen P53 0.0025 0.0031 0.0038
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0013 0.0011 0.0009
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0677 0.1133 0.1133
Trichomonas vaginalis DNA helicase recq1, putative 0.0013 0.0011 0.0379
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0071
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0362 0.06 0.06
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0012 0.0009 0.0131
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0024 0.003
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0013 0.0011 0.0171
Schistosoma mansoni hypothetical protein 0.0036 0.005 0.006
Schistosoma mansoni brg-1 associated factor 0.0036 0.005 0.006
Echinococcus multilocularis musashi 0.0017 0.0017 0.0017
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0018 0.002 0.029
Schistosoma mansoni hypothetical protein 0.0078 0.0121 0.0146
Leishmania major hypothetical protein, conserved 0.0151 0.0245 0.4068
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0036 0.005 0.1062
Schistosoma mansoni hypothetical protein 0.0106 0.0169 0.0203
Brugia malayi Regulator of G protein signaling domain containing protein 0.0012 0.0009 0.0061
Brugia malayi nuclear receptor NHR-88 0.0013 0.001 0.0067
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.1552 0.261 1
Brugia malayi Trypsin family protein 0.0021 0.0024 0.0165
Plasmodium vivax 6-phosphofructokinase, putative 0.0018 0.002 0.0403
Brugia malayi Nuclear hormone receptor-like 1 0.0155 0.025 0.1686
Plasmodium falciparum LCCL domain-containing protein 0.0242 0.0397 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0036 0.005 0.1188
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.2257 0.3802 0.3802
Brugia malayi CXXC zinc finger family protein 0.0017 0.0018 0.0119
Loa Loa (eye worm) hypothetical protein 0.0242 0.0397 0.2678
Echinococcus granulosus transmembrane protease serine 3 0.0021 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0362 0.06 0.4044
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0013 0.001 0.0067
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0238 0.0392 0.0392
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0005 0.0033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.005 0.006
Schistosoma mansoni intermediate filament proteins 0.0017 0.0017 0.0021
Echinococcus multilocularis regulator of G protein signaling 7 0.0012 0.0009 0.0009
Loa Loa (eye worm) glutamate receptor 1 0.0885 0.1484 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0024 0.003
Schistosoma mansoni regulator of G protein signaling 0.0012 0.0009 0.0011
Brugia malayi glutaminase DH11.1 0.0172 0.0279 0.1878
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0012 0.0009 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0012 0.0009 0.0131
Schistosoma mansoni rab6-interacting 0.0242 0.0397 0.0479
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0012 0.0009 0.0002
Entamoeba histolytica hypothetical protein 0.0023 0.0027 0.0435
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0024 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0165
Schistosoma mansoni hypothetical protein 0.0306 0.0506 0.061
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0165
Brugia malayi exodeoxyribonuclease III family protein 0.0012 0.0009 0.0059
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.001 0.0012
Entamoeba histolytica phosphofructokinase, putative 0.0068 0.0104 0.1722
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0013 0.001 0.0067
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0067
Schistosoma mansoni hypothetical protein 0.0306 0.0506 0.061
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0151 0.0245 0.6118
Echinococcus multilocularis SWI:SNF matrix associated 0.0036 0.005 0.005
Echinococcus granulosus tissue type plasminogen activator 0.0151 0.0245 0.0245
Brugia malayi Trypsin family protein 0.0021 0.0024 0.0165
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0013 0.001 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0009 0.0011
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1247 0.2095 0.2095
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0024 0.003
Echinococcus granulosus geminin 0.0106 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0151 0.0245 0.1649
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0013 0.001 0.0067
Loa Loa (eye worm) hypothetical protein 0.0306 0.0506 0.3409
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0297
Schistosoma mansoni hypothetical protein 0.0013 0.0011 0.0013
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0012 0.0009 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0024 0.003
Loa Loa (eye worm) glutaminase 2 0.0172 0.0279 0.1878
Echinococcus granulosus Polycystic kidney disease protein 0.0242 0.0397 0.0397
Echinococcus granulosus Regulator of G protein signaling 20 0.0012 0.0009 0.0009
Echinococcus multilocularis NMDA receptor 0.0706 0.1181 0.1181
Schistosoma mansoni regulator of G protein signaling 0.0012 0.0009 0.0011
Echinococcus granulosus regulator of G protein signaling 3 0.0012 0.0009 0.0009
Schistosoma mansoni cpg binding protein 0.0018 0.0019 0.0023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0165
Onchocerca volvulus 0.0362 0.06 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0012 0.0009 0.0201
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0089 0.0139 0.3524
Echinococcus multilocularis Mastin 0.0021 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0008 0.0002 0.0014
Schistosoma mansoni glutamate receptor NMDA 0.1025 0.172 0.2074
Echinococcus granulosus receptor type guanylyl cyclase 0.0362 0.06 0.06
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0706 0.1181 0.1181
Trypanosoma cruzi WLM domain containing protein, putative 0.0013 0.0011 0.0161
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0306 0.0506 0.061
Echinococcus multilocularis nmda type glutamate receptor 0.4031 0.6798 0.6798
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0013 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.001 0.001
Brugia malayi fructose-1,6-bisphosphatase 0.0238 0.0392 0.2638
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0024 0.003
Trichomonas vaginalis phosphofructokinase, putative 0.0068 0.0104 0.3714
Onchocerca volvulus 0.0036 0.005 0.0677
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0012 0.0009 0.0061
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0013 0.001 0.0012
Onchocerca volvulus 0.0017 0.0018 0.0129
Echinococcus multilocularis SWI:SNF matrix associated 0.0036 0.005 0.005
Toxoplasma gondii kringle domain-containing protein 0.0151 0.0245 0.6212
Schistosoma mansoni lamin 0.0017 0.0017 0.0021
Brugia malayi PXA domain containing protein 0.0012 0.0009 0.0061
Onchocerca volvulus 0.0021 0.0024 0.0245
Plasmodium vivax 6-phosphofructokinase, putative 0.0018 0.002 0.0403
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0012 0.0009 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0013 0.001 0.0067
Brugia malayi Nuclear hormone receptor-like 1 0.0155 0.025 0.1686
Echinococcus multilocularis regulator of G protein signaling 3 0.0012 0.0009 0.0009
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0068 0.0104 0.1722
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0078 0.0121 0.0121
Echinococcus multilocularis regulator of G protein signaling 7 0.0012 0.0009 0.0009
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1247 0.2095 0.2095
Trichomonas vaginalis phosphofructokinase, putative 0.0018 0.002 0.0686
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0021 0.0024 0.003
Schistosoma mansoni RAR-like nuclear receptor 0.0013 0.001 0.0012
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0012 0.0009 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0013 0.001 0.0067
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0012 0.0009 0.0131
Echinococcus granulosus lamin 0.0017 0.0017 0.0017
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0011 0.0379
Schistosoma mansoni tyrosine kinase 0.0362 0.06 0.0724
Schistosoma mansoni nuclear hormone receptor 0.0013 0.001 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0005 0.0033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0212
Brugia malayi Intermediate filament tail domain containing protein 0.0017 0.0017 0.0117
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0011 0.0247
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0024 0.0024
Onchocerca volvulus 0.0017 0.0017 0.0125
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0021 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0013 0.001 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0297
Echinococcus granulosus axis inhibition protein axin 0.0012 0.0009 0.0009
Mycobacterium ulcerans 6-phosphofructokinase 0.0068 0.0104 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0013 0.001 0.0067
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0071
Schistosoma mansoni transcription factor LCR-F1 0.0023 0.0027 0.0033
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0067
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0165
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0021 0.0024 0.0024
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0024 0.003
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0013 0.0011 0.0247
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0021 0.0024 0.0165
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0706 0.1181 0.1181
Onchocerca volvulus 0.0021 0.0024 0.0245
Entamoeba histolytica hypothetical protein 0.0023 0.0027 0.0435
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0013 0.001 0.001
Echinococcus multilocularis dnaJ subfamily B 0.0243 0.04 0.04
Leishmania major cytochrome p450-like protein 0.001 0.0005 0.0067
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0018 0.002 0.029
Loa Loa (eye worm) glutaminase 0.0172 0.0279 0.1878
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0013 0.001 0.0067
Brugia malayi Cytochrome P450 family protein 0.001 0.0005 0.0033
Loa Loa (eye worm) CXXC zinc finger family protein 0.0017 0.0018 0.0119
Toxoplasma gondii exonuclease III APE 0.0012 0.0009 0.0125
Echinococcus granulosus intermediate filament protein 0.0017 0.0017 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0011 0.0161
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0012 0.0009 0.0009
Echinococcus multilocularis beta adrenergic receptor kinase 0.0012 0.0009 0.0009
Echinococcus granulosus FTZ F1 alpha 0.0013 0.001 0.001
Echinococcus multilocularis glutamate receptor 2 0.0885 0.1484 0.1484
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0013 0.001 0.0067
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0117
Schistosoma mansoni regulator of G protein signaling 0.0012 0.0009 0.0011
Brugia malayi steroid hormone receptor 0.0013 0.001 0.0067
Echinococcus granulosus ecdysone induced protein 78C 0.0013 0.001 0.001
Loa Loa (eye worm) glutamate receptor 0.0362 0.06 0.4044
Loa Loa (eye worm) hypothetical protein 0.0008 0.0003 0.0018
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0013 0.001 0.001
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0012 0.0009 0.0011
Toxoplasma gondii ran binding protein 0.0013 0.0011 0.0171
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0238 0.0392 0.6519
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1247 0.2095 0.2095
Echinococcus granulosus cpg binding protein 0.0018 0.0019 0.0019
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0017 0.0017 0.0117
Brugia malayi brahma associated protein 60 kDa 0.0036 0.005 0.0337
Schistosoma mansoni loxhd1 0.0242 0.0397 0.0479
Onchocerca volvulus 0.0021 0.0024 0.0245
Schistosoma mansoni hypothetical protein 0.0023 0.0027 0.0033
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.1552 0.261 1
Schistosoma mansoni metabotropic glutamate receptor 0.0362 0.06 0.0724
Schistosoma mansoni RNA binding protein 0.0013 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0243 0.04 0.0482
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0706 0.1181 0.1181
Loa Loa (eye worm) hypothetical protein 0.0008 0.0002 0.0014
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0238 0.0392 0.0472
Echinococcus granulosus bloom syndrome protein 0.0013 0.0011 0.0011
Brugia malayi hypothetical protein 0.0242 0.0397 0.2678
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0036 0.005 0.1062
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.0067
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0071
Trichomonas vaginalis phosphofructokinase, putative 0.0018 0.002 0.0686
Schistosoma mansoni thyroid hormone receptor 0.0091 0.0142 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0009 0.0011
Brugia malayi Bloom's syndrome protein homolog 0.0013 0.0011 0.0077
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0009 0.0297
Schistosoma mansoni cercarial elastase (S01 family) 0.0021 0.0024 0.003
Schistosoma mansoni 6-phosphofructokinase 0.0068 0.0104 0.0126
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0013 0.001 0.0012
Echinococcus multilocularis cpg binding protein 0.0018 0.0019 0.0019
Schistosoma mansoni glutaminase 0.0172 0.0279 0.0336
Plasmodium falciparum cysteine repeat modular protein 1 0.0151 0.0245 0.6072
Brugia malayi regulator of G-protein signaling egl-10 0.0012 0.0009 0.0061
Loa Loa (eye worm) hypothetical protein 0.0154 0.0249 0.1678

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 60 uM Concentration required to produce 50% reduction in the rate of proliferation of L1210 cells ChEMBL. 3339610
IC50 (functional) = 60 uM Concentration required to produce 50% reduction in the rate of proliferation of L1210 cells ChEMBL. 3339610
IC50 (functional) = 100 uM Concentration required to produce 50% reduction in cloning of H.Ep.No.2 cells by 50% ChEMBL. 3339610
IC50 (functional) = 100 uM Concentration required to produce 50% reduction in cloning of H.Ep.No.2 cells by 50% ChEMBL. 3339610
MIC50 (functional) = 75 ug ml-1 The minimum inhibitory concentration required for 50% inhibition of vaccinia virus induced cytopathogenic effect in L929 cells ChEMBL. 3339610
Virus rating (functional) = 0.6 Virus rating on vaccinia virus measured as the degree of inhibition of virus induced cytopathogenic effect in L929 cells ChEMBL. 3339610

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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