Detailed information for compound 233391

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 333.728 | Formula: C11H16ClN5O5
  • H donors: 2 H acceptors: 3 LogP: 0.44 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@H]1N(C2OC(C(C2)N=[N+]=[N-])CO)C(=O)NC(=O)[C@@]1(C)Cl
  • InChi: 1S/C11H16ClN5O5/c1-11(12)8(19)14-10(20)17(9(11)21-2)7-3-5(15-16-13)6(4-18)22-7/h5-7,9,18H,3-4H2,1-2H3,(H,14,19,20)/t5?,6?,7?,9-,11-/m1/s1
  • InChiKey: GEKYZSAIEIUJRJ-HEZXHAFHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus potassium voltage gated channel protein 0.0149 0.0273 0.0733
Loa Loa (eye worm) animal heme peroxidase 0.0268 0.0604 0.0604
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Echinococcus granulosus potassium voltage gated channel protein 0.0149 0.0273 0.0733
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0149 0.0273 0.0733
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0171 0.0424
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0273 0.0616 0.331
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0688 0.1767 0.5429
Echinococcus multilocularis voltage dependent calcium channel 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Onchocerca volvulus Peroxidasin homolog 0.0268 0.0604 0.164
Brugia malayi cation channel family protein 0.0149 0.0273 0.0325
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0841 0.2192 0.2612
Schistosoma mansoni nAChR subunit 0.0841 0.2192 0.5888
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0157 0.0295 0.0793
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0149 0.0273 0.0733
Onchocerca volvulus 0.0841 0.2192 0.6812
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0171 0.0424
Trypanosoma brucei prolyl oligopeptidase, putative 0.0287 0.0654 0.3557
Echinococcus granulosus TRP transient receptor potential channel 0.0149 0.0273 0.0733
Brugia malayi sulfakinin receptor protein 0.013 0.022 0.0262
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0149 0.0273 0.0733
Toxoplasma gondii transporter, cation channel family protein 0.0149 0.0273 0.0427
Schistosoma mansoni transcription factor LCR-F1 0.0069 0.0053 0.0141
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Echinococcus multilocularis FTZ F1 alpha 0.1195 0.317 0.8518
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0206 0.043 0.1157
Echinococcus multilocularis glycine receptor subunit beta 0.0841 0.2192 0.5888
Onchocerca volvulus 0.0149 0.0273 0.0561
Echinococcus granulosus glycine receptor subunit beta 0.0841 0.2192 0.5888
Echinococcus granulosus tumor protein p63 0.0309 0.0718 0.1928
Echinococcus granulosus thyroid hormone receptor alpha 0.0563 0.1422 0.382
Schistosoma mansoni ryanodine receptor related 0.0149 0.0273 0.0733
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.1195 0.317 0.8518
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0088 0.0105 0.3155
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0157 0.0295 1
Loa Loa (eye worm) hypothetical protein 0.0432 0.1057 0.1057
Schistosoma mansoni voltage-gated potassium channel 0.0211 0.0446 0.1198
Brugia malayi Steroid receptor seven-up type 2 0.1195 0.317 0.3778
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.1195 0.317 0.8518
Echinococcus multilocularis slit 2 protein 0.0087 0.0101 0.027
Brugia malayi hypothetical protein 0.0149 0.0273 0.0325
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0088 0.0105 0.0126
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Brugia malayi Cation transporter family protein 0.0841 0.2192 0.2612
Schistosoma mansoni nuclear hormone receptor 0.0563 0.1422 0.382
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0237 0.0518 0.1034
Entamoeba histolytica hypothetical protein 0.0432 0.1057 1
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Loa Loa (eye worm) ACC-1 protein 0.0841 0.2192 0.2192
Trypanosoma cruzi oligopeptidase b 0.0287 0.0654 0.3557
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0841 0.2192 0.5888
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.1195 0.317 0.317
Toxoplasma gondii hypothetical protein 0.0149 0.0273 0.0427
Schistosoma mansoni hypothetical protein 0.0069 0.0053 0.0141
Loa Loa (eye worm) hypothetical protein 0.0268 0.0604 0.0604
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0287 0.0654 0.3557
Loa Loa (eye worm) hypothetical protein 0.0268 0.0604 0.0604
Onchocerca volvulus Dual oxidase homolog 0.0268 0.0604 0.164
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0841 0.2192 0.5888
Onchocerca volvulus Peroxidasin homolog 0.0268 0.0604 0.164
Echinococcus granulosus transient receptor potential cation channel 0.0158 0.0299 0.0802
Brugia malayi prolyl oligopeptidase family protein 0.0112 0.0171 0.0204
Schistosoma mansoni nuclear hormone receptor 0.1195 0.317 0.8518
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0841 0.2192 0.5888
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1305 0.3477 0.9341
Brugia malayi metabotropic glutamate receptor type 2 0.0091 0.0112 0.0133
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Echinococcus granulosus expressed conserved protein 0.0085 0.0095 0.0255
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0088 0.0105 0.0283
Echinococcus granulosus Niemann Pick C1 protein 0.009 0.011 0.0296
Echinococcus granulosus neural cadherin 0.0087 0.0101 0.027
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0149 0.0273 0.0325
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0841 0.2192 0.5888
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.1195 0.317 0.8518
Trypanosoma brucei RNA helicase, putative 0.01 0.0137 0.0207
Echinococcus multilocularis neurogenic locus notch protein 0.0087 0.0101 0.027
Brugia malayi Metabotropic glutamate receptor precursor. 0.0186 0.0376 0.0448
Echinococcus granulosus glycine receptor subunit alpha 1 0.0841 0.2192 0.5888
Brugia malayi prolyl oligopeptidase family protein 0.0688 0.1767 0.2106
Echinococcus granulosus protein jagged 2 0.0087 0.0101 0.027
Entamoeba histolytica prolyl oligopeptidase family protein 0.0112 0.0171 0.1178
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Onchocerca volvulus 0.0563 0.1422 0.4304
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0563 0.1422 0.382
Schistosoma mansoni microtubule-associated protein tau 0.0603 0.1532 0.4117
Echinococcus multilocularis potassium large conductance calcium activated 0.0149 0.0273 0.0733
Echinococcus multilocularis neurogenic locus notch protein 4 0.0087 0.0101 0.027
Brugia malayi steroid hormone receptor 0.1195 0.317 0.3778
Brugia malayi Calcium binding EGF domain containing protein 0.0087 0.0101 0.012
Loa Loa (eye worm) hypothetical protein 0.0563 0.1422 0.1422
Brugia malayi Animal haem peroxidase family protein 0.0268 0.0604 0.072
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0087 0.0101 0.027
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0841 0.2192 0.5888
Loa Loa (eye worm) hypothetical protein 0.0563 0.1422 0.1422
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0409 0.0995 0.1186
Schistosoma mansoni two-pore calcium channel 0.0149 0.0273 0.0733
Onchocerca volvulus 0.0841 0.2192 0.6812
Echinococcus multilocularis hyperpolarization activated cyclic 0.0157 0.0295 0.0793
Schistosoma mansoni retinoic acid receptor RXR 0.1195 0.317 0.8518
Giardia lamblia Hypothetical protein 0.0088 0.0105 0.0013
Loa Loa (eye worm) hypothetical protein 0.1195 0.317 0.317
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0273 0.0616 0.1279
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Echinococcus granulosus glycine receptor subunit alpha 1 0.0841 0.2192 0.5888
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0149 0.0273 0.0733
Schistosoma mansoni transient receptor potential channel 0.0158 0.0299 0.0802
Loa Loa (eye worm) hypothetical protein 0.0112 0.0171 0.0171
Echinococcus granulosus Dipeptidyl peptidase 9 0.0273 0.0616 0.1656
Loa Loa (eye worm) voltage-gated potassium channel 0.0149 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0563 0.1422 0.382
Brugia malayi hypothetical protein 0.0631 0.1609 0.1917
Brugia malayi EGF-like domain containing protein 0.0087 0.0101 0.012
Echinococcus granulosus notch 0.0087 0.0101 0.027
Brugia malayi prolyl oligopeptidase family protein 0.0112 0.0171 0.0204
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0088 0.0105 0.3155
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0088 0.0105 0.3155
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0268 0.0604 0.0604
Brugia malayi Nuclear hormone receptor family member nhr-40 0.1195 0.317 0.3778
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Echinococcus granulosus potassium voltage gated channel protein 0.0149 0.0273 0.0733
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0273 0.0733
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0409 0.0995 0.1186
Leishmania major hypothetical protein, unknown function 0.0149 0.0273 0.1084
Schistosoma mansoni hypothetical protein 0.0187 0.0378 0.1015
Loa Loa (eye worm) DR-78 0.0563 0.1422 0.1422
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0688 0.1767 0.4748
Brugia malayi voltage-dependent calcium channel 0.0149 0.0273 0.0325
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0432 0.1057 0.126
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.1195 0.317 0.3778
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0563 0.1422 0.382
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0631 0.1609 0.4323
Brugia malayi GCC2 and GCC3 family protein 0.0087 0.0101 0.012
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0112 0.0171 0.0459
Echinococcus multilocularis shaker cognate 0.0149 0.0273 0.0733
Echinococcus multilocularis voltage dependent calcium channel 0.0149 0.0273 0.0733
Onchocerca volvulus Chorion peroxidase homolog 0.0268 0.0604 0.164
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0087 0.0101 0.000000098902
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0157 0.0295 0.0793
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0157 0.0295 0.0793
Loa Loa (eye worm) hypothetical protein 0.0088 0.0105 0.0105
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0149 0.0273 0.1084
Toxoplasma gondii hypothetical protein 0.0149 0.0273 0.0427
Onchocerca volvulus 0.0409 0.0995 0.2913
Brugia malayi Muscle positioning protein 4 0.0087 0.0101 0.012
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Brugia malayi Nuclear hormone receptor-like 1 0.0631 0.1609 0.1917
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0088 0.0105 0.3155
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0549 0.1383 0.3714
Schistosoma mansoni peroxidasin 0.0268 0.0604 0.1623
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0287 0.0654 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0841 0.2192 0.2612
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0563 0.1422 0.382
Schistosoma mansoni septate junction protein 0.0087 0.0101 0.027
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.1195 0.317 0.8518
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0273 0.0733
Brugia malayi EGF-like domain containing protein 0.0087 0.0101 0.012
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0563 0.1422 0.4304
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.1195 0.317 0.8518
Echinococcus multilocularis nuclear receptor nhr 48 0.0563 0.1422 0.382
Brugia malayi nuclear hormone receptor 0.0563 0.1422 0.1694
Brugia malayi olfactory channel protein osm-9 0.0158 0.0299 0.0356
Echinococcus granulosus potassium large conductance calcium activated 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0841 0.2192 0.2612
Onchocerca volvulus Neurogenic locus notch homolog 0.0096 0.0127 0.0084
Echinococcus multilocularis expressed conserved protein 0.0085 0.0095 0.0255
Schistosoma mansoni nAChR subunit 0.0841 0.2192 0.5888
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0409 0.0995 0.1186
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0631 0.1609 0.1609
Onchocerca volvulus 0.0841 0.2192 0.6812
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0112 0.0171 0.0171
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0149 0.0273 0.0561
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0088 0.0105 0.3155
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0841 0.2192 0.5888
Echinococcus granulosus two pore calcium channel protein 2 0.0149 0.0273 0.0733
Brugia malayi Nuclear hormone receptor family member nhr-19 0.1195 0.317 0.3778
Echinococcus granulosus neurogenic locus notch protein 0.0087 0.0101 0.027
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0088 0.0105 0.0283
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0149 0.0273 0.0325
Loa Loa (eye worm) prolyl oligopeptidase 0.0112 0.0171 0.0171
Brugia malayi Nuclear hormone receptor E75 0.0563 0.1422 0.1694
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0841 0.2192 0.2192
Schistosoma mansoni voltage-gated ion channel 0.0149 0.0273 0.0733
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.1195 0.317 0.317
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0409 0.0995 0.1186
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0149 0.0273 0.0325
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.009 0.011 0.0572
Brugia malayi conserved hypotetical protein 0.0563 0.1422 0.1694
Echinococcus multilocularis neurogenic locus protein delta 0.0087 0.0101 0.027
Brugia malayi Nuclear hormone receptor family member nhr-14 0.1195 0.317 0.3778
Onchocerca volvulus 0.0563 0.1422 0.4304
Echinococcus multilocularis fibropellin Ia 0.0087 0.0101 0.027
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0149 0.0273 0.1084
Trypanosoma brucei prolyl endopeptidase 0.0646 0.1649 1
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.009 0.011 0.011
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.2483 0.6742 1
Schistosoma mansoni voltage-gated potassium channel 0.0211 0.0446 0.1198
Echinococcus granulosus short transient receptor potential channel 6 0.0158 0.0299 0.0802
Loa Loa (eye worm) hypothetical protein 0.0563 0.1422 0.1422
Echinococcus multilocularis transient receptor potential cation channel 0.0158 0.0299 0.0802
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0206 0.043 0.043
Brugia malayi hypothetical protein 0.0563 0.1422 0.1694
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Brugia malayi notch-like transmembrane receptor 0.0087 0.0101 0.012
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0171 0.0099
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.1195 0.317 0.8518
Echinococcus multilocularis conserved hypothetical protein 0.0149 0.0273 0.0733
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0841 0.2192 0.5888
Loa Loa (eye worm) hypothetical protein 0.1394 0.3722 0.3722
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0646 0.1649 0.443
Echinococcus multilocularis peroxidasin 0.0268 0.0604 0.1623
Echinococcus granulosus transient receptor potential cation channel 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0409 0.0995 0.0995
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0088 0.0105 0.3155
Trypanosoma brucei oligopeptidase b 0.0287 0.0654 0.3557
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.1195 0.317 0.317
Schistosoma mansoni nAChR subunit 0.0841 0.2192 0.5888
Echinococcus granulosus nuclear receptor 2DBD gamma 0.1195 0.317 0.8518
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Schistosoma mansoni hypothetical protein 0.01 0.0137 0.0369
Brugia malayi nuclear receptor NHR-88 0.1195 0.317 0.3778
Schistosoma mansoni voltage-gated potassium channel 0.0162 0.0311 0.0834
Schistosoma mansoni metabotropic glutamate receptor 0.0156 0.0292 0.0785
Brugia malayi excitatory GABA receptor EXP-1A 0.0841 0.2192 0.2612
Echinococcus multilocularis nAChR subunit 0.0841 0.2192 0.5888
Brugia malayi hypothetical protein 0.0268 0.0604 0.072
Brugia malayi EGF-like domain containing protein 0.0087 0.0101 0.012
Loa Loa (eye worm) animal heme peroxidase 0.0268 0.0604 0.0604
Brugia malayi Nuclear hormone receptor-like 1 0.0631 0.1609 0.1917
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.1394 0.3722 1
Echinococcus multilocularis acylamino acid releasing enzyme 0.0112 0.0171 0.0459
Echinococcus multilocularis ecdysone induced protein 78C 0.1195 0.317 0.8518
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1394 0.3722 1
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0149 0.0273 0.0733
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0088 0.0105 0.0126
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0841 0.2192 0.5888
Brugia malayi hypothetical protein 0.013 0.022 0.0262
Echinococcus multilocularis nAChR subunit 0.0432 0.1057 0.284
Loa Loa (eye worm) hypothetical protein 0.0268 0.0604 0.0604
Schistosoma mansoni laminin gamma-3 chain 0.0087 0.0101 0.027
Loa Loa (eye worm) hypothetical protein 0.0162 0.0311 0.0311
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.1195 0.317 0.317
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0088 0.0105 0.3155
Loa Loa (eye worm) ACC-1 protein 0.0841 0.2192 0.2192
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0105 0.3155
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0092 0.0114 0.0306
Loa Loa (eye worm) animal heme peroxidase 0.0268 0.0604 0.0604
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0841 0.2192 0.5888
Onchocerca volvulus 0.0841 0.2192 0.6812
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0088 0.0105 0.3155
Schistosoma mansoni thyroid hormone receptor 0.1195 0.317 0.8518
Giardia lamblia hypothetical protein 0.0088 0.0105 0.0013
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.3079 0.8392 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0841 0.2192 0.2192
Loa Loa (eye worm) hypothetical protein 0.0167 0.0323 0.0323
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1543 0.4135 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Schistosoma mansoni neurotransmitter gated ion channel 0.0409 0.0995 0.2673
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0206 0.043 0.1157
Schistosoma mansoni hypothetical protein 0.0087 0.0101 0.027
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0229 0.0495 0.0495
Loa Loa (eye worm) GABA receptor subunit 0.0432 0.1057 0.1057
Echinococcus granulosus retinoic acid receptor rxr beta a 0.1195 0.317 0.8518
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0171 0.5519
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0088 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Loa Loa (eye worm) hypothetical protein 0.0268 0.0604 0.0604
Echinococcus multilocularis hyperpolarization activated cyclic 0.0157 0.0295 0.0793
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0088 0.0105 0.0283
Loa Loa (eye worm) prolyl oligopeptidase 0.0688 0.1767 0.1767
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Echinococcus multilocularis notch 0.0087 0.0101 0.027
Brugia malayi hypothetical protein 0.0409 0.0995 0.1186
Plasmodium falciparum peptidase, putative 0.0112 0.0171 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0149 0.0273 0.0733
Schistosoma mansoni hypothetical protein 0.0187 0.0378 0.1015
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Echinococcus granulosus potassium voltage gated channel protein 0.0149 0.0273 0.0733
Trypanosoma cruzi oligopeptidase b 0.0287 0.0654 0.3557
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0088 0.0105 0.0283
Echinococcus multilocularis short transient receptor potential channel 6 0.0149 0.0273 0.0733
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Echinococcus multilocularis ryanodine receptor 44f 0.0149 0.0273 0.0733
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0273 0.0733
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0432 0.1057 0.126
Loa Loa (eye worm) hypothetical protein 0.013 0.022 0.022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.1195 0.317 0.3778
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0229 0.0495 0.1329
Loa Loa (eye worm) hypothetical protein 0.0268 0.0604 0.0604
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0088 0.0105 0.0126
Loa Loa (eye worm) animal heme peroxidase 0.0268 0.0604 0.0604
Echinococcus granulosus metabotropic glutamate receptor 5 0.0229 0.0495 0.1329
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0149 0.0273 0.1084
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0149 0.0273 0.0733
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.1195 0.317 0.317
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1394 0.3722 1
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Echinococcus granulosus glycine receptor subunit beta 0.0841 0.2192 0.5888
Echinococcus granulosus neurogenic locus notch protein 0.0087 0.0101 0.027
Echinococcus granulosus transient receptor potential gamma protein 0.0149 0.0273 0.0733
Schistosoma mansoni nAChR subunit 0.0409 0.0995 0.2673
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0273 0.0616 0.1656
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0841 0.2192 0.5888
Echinococcus granulosus hypothetical protein 0.0465 0.115 0.3088
Echinococcus granulosus microtubule associated protein 2 0.0603 0.1532 0.4117
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0149 0.0273 0.0733
Schistosoma mansoni nuclear hormone receptor 0.0563 0.1422 0.382
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0841 0.2192 0.2612
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1394 0.3722 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0149 0.0273 0.0733
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0841 0.2192 0.5888
Echinococcus granulosus sodium leak channel non selective protein 0.0149 0.0273 0.0733
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0841 0.2192 0.2612
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Brugia malayi EGF-like domain containing protein 0.0087 0.0101 0.012
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0841 0.2192 0.2192
Echinococcus multilocularis transient receptor potential gamma protein 0.0149 0.0273 0.0733
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0149 0.0273 0.0733
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0841 0.2192 0.5888
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0149 0.0273 0.0733
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.1305 0.3477 0.4143
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0432 0.1057 0.284
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Brugia malayi EGF-like domain containing protein 0.0087 0.0101 0.012
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0563 0.1422 0.382
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Onchocerca volvulus 0.0432 0.1057 0.3116
Schistosoma mansoni metabotropic glutamate receptor 0.0091 0.0112 0.03
Schistosoma mansoni nAChR subunit 0.0841 0.2192 0.5888
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0088 0.0105 0.3155
Toxoplasma gondii prolyl endopeptidase 0.0646 0.1649 0.3838
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0841 0.2192 0.5888
Brugia malayi Protein kinase domain containing protein 0.0549 0.1383 0.1647
Echinococcus granulosus acylamino acid releasing enzyme 0.0112 0.0171 0.0459
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0149 0.0273 0.0325
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0157 0.0295 0.0793
Echinococcus granulosus transient receptor potential cation channel 0.0149 0.0273 0.0733
Brugia malayi EGF-like domain containing protein 0.0087 0.0101 0.012
Echinococcus granulosus Nuclear hormone receptor HR96 0.0563 0.1422 0.382
Echinococcus multilocularis transient receptor potential cation channel 0.0149 0.0273 0.0733
Echinococcus multilocularis sodium channel protein 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0167 0.0323 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0105 0.3155
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0157 0.0295 0.0793
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.1195 0.317 0.8518
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Schistosoma mansoni hypothetical protein 0.0087 0.0101 0.027
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0088 0.0105 0.0283
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0112 0.0171 0.0174
Loa Loa (eye worm) hypothetical protein 0.0198 0.0408 0.0408
Echinococcus multilocularis serotonin receptor 0.0167 0.0323 0.0869
Schistosoma mansoni transient receptor potential channel 4 0.0149 0.0273 0.0733
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0273 0.0616 0.331
Brugia malayi hypothetical protein 0.0161 0.0306 0.0364
Loa Loa (eye worm) hypothetical protein 0.0563 0.1422 0.1422
Onchocerca volvulus 0.1195 0.317 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Echinococcus granulosus fibropellin Ia 0.0087 0.0101 0.027
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.1195 0.317 0.8518
Echinococcus multilocularis transient receptor potential cation channel 0.0158 0.0299 0.0802
Onchocerca volvulus 0.0268 0.0604 0.164
Echinococcus granulosus protein jagged 1 0.0087 0.0101 0.027
Brugia malayi Cation transporter family protein 0.0841 0.2192 0.2612
Leishmania major hypothetical protein, conserved 0.0149 0.0273 0.1084
Loa Loa (eye worm) hypothetical protein 0.0563 0.1422 0.1422
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0162 0.0311 0.037
Brugia malayi nuclear receptor NHR-67 0.0563 0.1422 0.1694
Echinococcus granulosus biogenic amine 5HT receptor 0.0167 0.0323 0.0869
Brugia malayi prolyl oligopeptidase family protein 0.0646 0.1649 0.1965
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0273 0.0733
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0273 0.0616 0.331
Loa Loa (eye worm) hypothetical protein 0.1195 0.317 0.317
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0088 0.0105 0.0126
Schistosoma mansoni notch 0.0087 0.0101 0.027
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0069 0.0053 0.0141
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0549 0.1383 0.1647
Brugia malayi Transient-receptor-potential like protein 0.0149 0.0273 0.0325
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0432 0.1057 0.1057
Echinococcus multilocularis microtubule associated protein 2 0.0603 0.1532 0.4117
Brugia malayi Nuclear hormone receptor family member nhr-31 0.1195 0.317 0.3778
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0149 0.0273 0.0325
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0087 0.0101 0.012
Echinococcus multilocularis geminin 0.0187 0.0378 0.1015
Echinococcus multilocularis Niemann Pick C1 protein 0.0129 0.0217 0.0584
Brugia malayi Animal haem peroxidase family protein 0.0268 0.0604 0.072
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0432 0.1057 0.126
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0841 0.2192 0.2612
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0088 0.0105 0.0283
Echinococcus granulosus potassium voltage gated channel protein 0.0149 0.0273 0.0733
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0157 0.0295 0.0295
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0157 0.0295 0.0793
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0273 0.0733
Loa Loa (eye worm) voltage-dependent calcium channel 0.0149 0.0273 0.0273
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0149 0.0273 0.1084
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0563 0.1422 0.1422
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0549 0.1383 0.1383
Loa Loa (eye worm) glutamate receptor 0.0186 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0162 0.0311 0.0834
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0287 0.0654 0.3557
Echinococcus multilocularis neural cadherin 0.0087 0.0101 0.027
Schistosoma mansoni voltage-gated cation channel 0.0149 0.0273 0.0733
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0149 0.0273 0.0733
Schistosoma mansoni slit 0.0087 0.0101 0.027
Echinococcus granulosus neurogenic locus protein delta 0.0087 0.0101 0.027
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0088 0.0105 0.0283
Echinococcus multilocularis voltage gated potassium channel 0.0149 0.0273 0.0733
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0088 0.0105 0.0283
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0149 0.0273 0.0733
Schistosoma mansoni hypothetical protein 0.0087 0.0101 0.027
Echinococcus granulosus nuclear receptor nhr 48 0.0563 0.1422 0.382
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0273 0.0733
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0088 0.0105 0.0283
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0149 0.0273 0.0733
Brugia malayi Calcium binding EGF domain containing protein 0.0087 0.0101 0.012
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Schistosoma mansoni RAR-like nuclear receptor 0.1195 0.317 0.8518
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0841 0.2192 0.5888
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0149 0.0273 0.1084
Brugia malayi Calcium binding EGF domain containing protein 0.0087 0.0101 0.012
Loa Loa (eye worm) notch protein 0.0087 0.0101 0.0101
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0157 0.0295 0.0793
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0409 0.0995 0.2673
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Loa Loa (eye worm) nuclear hormone receptor 0.0563 0.1422 0.1422
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0149 0.0273 0.0325
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0841 0.2192 0.5888
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Trypanosoma cruzi prolyl endopeptidase 0.0646 0.1649 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.1195 0.317 0.3778
Echinococcus multilocularis two pore calcium channel protein 1 0.0149 0.0273 0.0733
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0149 0.0273 0.0561
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.1195 0.317 0.3778
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0841 0.2192 0.2612
Brugia malayi EGF-like domain containing protein 0.0087 0.0101 0.012
Echinococcus granulosus Nuclear hormone receptor HR96 0.0563 0.1422 0.382
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Schistosoma mansoni voltage-gated potassium channel 0.0157 0.0295 0.0793
Schistosoma mansoni nuclear receptor 0.0563 0.1422 0.382
Loa Loa (eye worm) hypothetical protein 0.0088 0.0105 0.0105
Schistosoma mansoni peroxidasin 0.0268 0.0604 0.1623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.1195 0.317 0.317
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0149 0.0273 0.0733
Schistosoma mansoni neurotransmitter gated ion channel 0.0432 0.1057 0.284
Brugia malayi nuclear hormone receptor family member nhr-6 0.0563 0.1422 0.1694
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0841 0.2192 0.2612
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.1195 0.317 0.8518
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0088 0.0105 0.0283
Brugia malayi Cation transporter family protein 0.0841 0.2192 0.2612
Echinococcus granulosus hyperpolarization activated cyclic 0.0157 0.0295 0.0793
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0157 0.0295 0.0793
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0149 0.0273 0.0325
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0432 0.1057 0.126
Schistosoma mansoni coup transcription factor 0.1195 0.317 0.8518
Loa Loa (eye worm) hypothetical protein 0.1195 0.317 0.317
Echinococcus granulosus two pore calcium channel protein 1 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Echinococcus granulosus neurogenic locus notch protein 4 0.0087 0.0101 0.027
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0206 0.043 0.0513
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0549 0.1383 0.3714
Echinococcus granulosus nAChR subunit 0.0432 0.1057 0.284
Toxoplasma gondii transporter, cation channel family protein 0.0149 0.0273 0.0427
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0409 0.0995 0.2673
Schistosoma mansoni hypothetical protein 0.0087 0.0101 0.027
Schistosoma mansoni serine/threonine protein kinase 0.0549 0.1383 0.3714
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0149 0.0273 0.0733
Schistosoma mansoni nAChR subunit 0.0409 0.0995 0.2673
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0088 0.0105 0.0283
Echinococcus multilocularis protein jagged 1 0.0087 0.0101 0.027
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0088 0.0105 0.3155
Giardia lamblia Alanyl dipeptidyl peptidase 0.0112 0.0171 0.0194
Echinococcus granulosus protein jagged 2 0.0087 0.0101 0.027
Loa Loa (eye worm) blistered cuticle protein 3 0.0268 0.0604 0.0604
Echinococcus multilocularis potassium voltage gated channel protein 0.0149 0.0273 0.0733
Loa Loa (eye worm) voltage-gated calcium channel 0.0149 0.0273 0.0273
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0088 0.0105 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-3 0.1195 0.317 0.3778
Entamoeba histolytica prolyl oligopeptidase family protein 0.0112 0.0171 0.1178
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0149 0.0273 0.0325
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Schistosoma mansoni hypothetical protein 0.0087 0.0101 0.027
Schistosoma mansoni voltage-gated potassium channel 0.0154 0.0288 0.0775
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.1195 0.317 0.8518
Onchocerca volvulus 0.0432 0.1057 0.3116
Echinococcus granulosus voltage dependent calcium channel 0.0149 0.0273 0.0733
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Echinococcus multilocularis Niemann Pick C1 protein 0.009 0.011 0.0296
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1394 0.3722 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0088 0.0105 0.0283
Echinococcus multilocularis transient receptor potential cation channel 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Echinococcus multilocularis two pore calcium channel protein 2 0.0149 0.0273 0.0733
Echinococcus granulosus Niemann Pick C1 protein 0.0129 0.0217 0.0584
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Brugia malayi nuclear hormone receptor family member odr-7 0.0563 0.1422 0.1694
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0088 0.0105 0.0283
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0841 0.2192 0.2612
Schistosoma mansoni transient receptor potential channel 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.1195 0.317 0.317
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0287 0.0654 0.3557
Loa Loa (eye worm) ryanodine receptor 0.0149 0.0273 0.0273
Echinococcus multilocularis glycine receptor subunit beta 0.0841 0.2192 0.5888
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0273 0.0733
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0533 0.1338 1
Echinococcus multilocularis tumor protein p63 0.0309 0.0718 0.1928
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0088 0.0105 0.0283
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0273 0.0733
Schistosoma mansoni hypothetical protein 0.0149 0.0273 0.0733
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0841 0.2192 0.2192
Echinococcus multilocularis sodium leak channel non selective protein 0.0149 0.0273 0.0733
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0157 0.0295 1
Onchocerca volvulus Peroxidase homolog 0.0268 0.0604 0.164
Loa Loa (eye worm) hypothetical protein 0.0088 0.0105 0.0105
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0409 0.0995 0.1186
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0088 0.0105 0.0126
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0112 0.0171 0.1178
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Loa Loa (eye worm) hypothetical protein 0.1195 0.317 0.317
Schistosoma mansoni zinc finger protein 0.0563 0.1422 0.382
Echinococcus granulosus sodium channel protein 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0841 0.2192 0.5888
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0841 0.2192 0.5888
Loa Loa (eye worm) hypothetical protein 0.0268 0.0604 0.0604
Onchocerca volvulus 0.0409 0.0995 0.2913
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0112 0.0171 0.1178
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0563 0.1422 0.382
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0149 0.0273 0.0325
Brugia malayi hypothetical protein 0.0563 0.1422 0.1694
Schistosoma mansoni voltage-gated potassium channel 0.0162 0.0311 0.0834
Brugia malayi hypothetical protein 0.0069 0.0053 0.0063
Schistosoma mansoni neurotransmitter gated ion channel 0.0409 0.0995 0.2673
Echinococcus granulosus short transient receptor potential channel 6 0.0149 0.0273 0.0733
Schistosoma mansoni nAChR subunit 0.0841 0.2192 0.5888
Schistosoma mansoni acetylcholine receptor subunit beta 0.0409 0.0995 0.2673
Loa Loa (eye worm) hypothetical protein 0.0563 0.1422 0.1422
Brugia malayi ecdysteroid receptor 0.1195 0.317 0.3778
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0149 0.0273 0.0733
Brugia malayi Nuclear hormone receptor family member nhr-41 0.1195 0.317 0.3778
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0149 0.0273 0.0325
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0088 0.0105 0.0283
Loa Loa (eye worm) hypothetical protein 0.3079 0.8392 0.8392
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0212 0.0446 0.1199
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0631 0.1609 0.1609
Loa Loa (eye worm) hypothetical protein 0.0161 0.0306 0.0306
Brugia malayi cation channel family protein 0.0149 0.0273 0.0325
Echinococcus granulosus voltage dependent calcium channel 0.0149 0.0273 0.0733
Toxoplasma gondii hypothetical protein 0.0112 0.0171 0.0174
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0088 0.0105 0.0283
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0841 0.2192 0.2612
Loa Loa (eye worm) hypothetical protein 0.0268 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0563 0.1422 0.1422
Entamoeba histolytica prolyl oligopeptidase family protein 0.0112 0.0171 0.1178
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0631 0.1609 0.4323
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0149 0.0273 0.0733
Echinococcus granulosus voltage gated hydrogen channel 1 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0563 0.1422 0.1422
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0688 0.1767 0.4748
Schistosoma mansoni notch 0.0087 0.0101 0.027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0088 0.0105 0.3155
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.1305 0.3477 0.3477
Brugia malayi Animal haem peroxidase family protein 0.0268 0.0604 0.072
Echinococcus multilocularis protein jagged 2 0.0087 0.0101 0.027
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0088 0.0105 0.0283
Echinococcus multilocularis calcium activated potassium channel 0.015 0.0277 0.0745
Echinococcus granulosus slit 2 protein 0.0087 0.0101 0.027
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0841 0.2192 0.5888
Loa Loa (eye worm) hypothetical protein 0.0409 0.0995 0.0995
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0409 0.0995 0.1186
Schistosoma mansoni hypothetical protein 0.0087 0.0101 0.027
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Brugia malayi Nuclear hormone receptor family member nhr-25 0.1195 0.317 0.3778
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Schistosoma mansoni Tr4/Tr2 (homologue) 0.1195 0.317 0.8518
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0088 0.0105 0.0283
Echinococcus multilocularis voltage gated potassium channel 0.0162 0.0311 0.0834
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0841 0.2192 0.2612
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0841 0.2192 0.2612
Schistosoma mansoni vesicular amine transporter 0.0149 0.0273 0.0733
Echinococcus granulosus transient receptor potential cation channel 0.0149 0.0273 0.0733
Schistosoma mansoni nAChR subunit 0.0841 0.2192 0.5888
Onchocerca volvulus 0.0268 0.0604 0.164
Loa Loa (eye worm) hypothetical protein 0.0268 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0631 0.1609 0.1609
Loa Loa (eye worm) hypothetical protein 0.1195 0.317 0.317
Loa Loa (eye worm) hypothetical protein 0.0432 0.1057 0.1057
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0563 0.1422 0.4304
Loa Loa (eye worm) hypothetical protein 0.0268 0.0604 0.0604
Schistosoma mansoni transient receptor potential channel 0.0149 0.0273 0.0733
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0088 0.0105 0.3155
Echinococcus granulosus delta-like protein 1 0.0087 0.0101 0.027
Loa Loa (eye worm) hypothetical protein 0.1195 0.317 0.317
Brugia malayi Blistered cuticle protein 3 0.0268 0.0604 0.072
Echinococcus granulosus protein jagged 1 0.0087 0.0101 0.027
Echinococcus granulosus peroxidasin 0.0268 0.0604 0.1623
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0432 0.1057 0.284
Schistosoma mansoni steroid hormone receptor ad4bp 0.1195 0.317 0.8518
Onchocerca volvulus Putative nachr subunit 0.0841 0.2192 0.6812
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0273 0.0616 0.331
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0409 0.0995 0.0995
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0088 0.0105 0.3155
Loa Loa (eye worm) hypothetical protein 0.0563 0.1422 0.1422
Schistosoma mansoni biogenic amine (5HT) receptor 0.0167 0.0323 0.0869
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0169 0.0327 0.039
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Loa Loa (eye worm) hypothetical protein 0.0432 0.1057 0.1057
Brugia malayi Nuclear hormone receptor family member nhr-1 0.1195 0.317 0.3778
Brugia malayi Cadherin domain containing protein 0.0087 0.0101 0.012
Loa Loa (eye worm) hypothetical protein 0.1195 0.317 0.317
Onchocerca volvulus 0.0841 0.2192 0.6812
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0149 0.0273 0.0733
Onchocerca volvulus 0.0268 0.0604 0.164
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0563 0.1422 0.1422
Loa Loa (eye worm) LGC-31 protein 0.0841 0.2192 0.2192
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0156 0.0292 0.0785
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0088 0.0105 0.0283
Schistosoma mansoni notch 0.0087 0.0101 0.027
Brugia malayi Animal haem peroxidase family protein 0.0268 0.0604 0.072
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0409 0.0995 0.2673
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0432 0.1057 0.1057
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1394 0.3722 1
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0149 0.0273 0.0733
Loa Loa (eye worm) Notch2 0.0087 0.0101 0.0101
Brugia malayi hypothetical protein 0.0409 0.0995 0.1186
Brugia malayi ion channel NompC 0.0149 0.0273 0.0325
Echinococcus granulosus calcium activated potassium channel 0.015 0.0277 0.0745
Echinococcus multilocularis conserved hypothetical protein 0.0441 0.1081 0.2905
Schistosoma mansoni acetylcholine receptor-related 0.0409 0.0995 0.2673
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0409 0.0995 0.2673
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Brugia malayi tailless protein 0.0563 0.1422 0.1694
Schistosoma mansoni cell polarity protein 0.0087 0.0101 0.027
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.1195 0.317 0.8518
Echinococcus granulosus shaker cognate 0.0149 0.0273 0.0733
Onchocerca volvulus 0.0409 0.0995 0.2913
Echinococcus granulosus metabotropic glutamate receptor 2 0.0156 0.0292 0.0785
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0088 0.0105 0.3155
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0549 0.1383 0.1383
Brugia malayi nuclear receptor RXR 0.0563 0.1422 0.1694
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0088 0.0105 0.0126
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0841 0.2192 0.5888
Onchocerca volvulus Protein ultraspiracle homolog 0.1195 0.317 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0563 0.1422 0.382
Schistosoma mansoni voltage-dependent calcium channel 0.0149 0.0273 0.0733
Echinococcus multilocularis serotonin receptor 0.0167 0.0323 0.0869
Onchocerca volvulus Peroxidase homolog 0.0268 0.0604 0.164
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0088 0.0105 0.0283
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0841 0.2192 0.5888
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0149 0.0273 0.0733
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.1195 0.317 0.8518
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Echinococcus multilocularis neurogenic locus protein delta 0.0087 0.0101 0.027
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0268 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Echinococcus granulosus hypothetical protein 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0432 0.1057 0.1057
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Echinococcus granulosus prolyl endopeptidase 0.0646 0.1649 0.443
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0273 0.0733
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.1195 0.317 1
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0646 0.1649 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0465 0.1149 0.3087
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0273 0.0733
Loa Loa (eye worm) acetylcholine receptor protein 0.0409 0.0995 0.0995
Loa Loa (eye worm) voltage-gated potassium channel 0.0149 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Brugia malayi Cyclic-nucleotide gated cation channel 0.0157 0.0295 0.0352
Loa Loa (eye worm) hypothetical protein 0.0631 0.1609 0.1609
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0409 0.0995 0.2673
Loa Loa (eye worm) hypothetical protein 0.0563 0.1422 0.1422
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Brugia malayi hypothetical protein 0.0409 0.0995 0.1186
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0841 0.2192 0.5888
Loa Loa (eye worm) hypothetical protein 0.0631 0.1609 0.1609
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0841 0.2192 0.2192
Brugia malayi nuclear hormone receptor 0.1195 0.317 0.3778
Echinococcus multilocularis transient receptor potential cation channel 0.0149 0.0273 0.0733
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0157 0.0295 0.0793
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0563 0.1422 0.382
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0287 0.0654 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0268 0.0604 0.0604
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0088 0.0105 0.3155
Brugia malayi orphan nuclear receptor NR2E1 0.0563 0.1422 0.1694
Brugia malayi Delta serrate ligand family protein 0.0087 0.0101 0.012
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0841 0.2192 0.5888
Leishmania major oligopeptidase b 0.0287 0.0654 0.3557
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0841 0.2192 0.2612
Echinococcus granulosus glycine receptor subunit alpha 1 0.0841 0.2192 0.5888
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0157 0.0295 0.0793
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0149 0.0273 0.0733
Echinococcus multilocularis protein jagged 1 0.0087 0.0101 0.027
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0563 0.1422 0.382
Loa Loa (eye worm) hypothetical protein 0.0149 0.0273 0.0273
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0549 0.1383 0.4176
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0112 0.0171 0.0424
Onchocerca volvulus Prolyl endopeptidase homolog 0.0646 0.1649 0.5044
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0841 0.2192 0.2192
Brugia malayi hypothetical protein 0.0631 0.1609 0.1917
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.1195 0.317 0.8518
Schistosoma mansoni biogenic amine (5HT) receptor 0.0465 0.1149 0.3087
Echinococcus granulosus nAChR subunit 0.0841 0.2192 0.5888
Brugia malayi hypothetical protein 0.0409 0.0995 0.1186
Schistosoma mansoni calcium-activated potassium channel 0.0149 0.0273 0.0733
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0112 0.0171 0.5519
Brugia malayi nuclear receptor RXR 0.0631 0.1609 0.1917
Loa Loa (eye worm) steroid hormone receptor 0.1195 0.317 0.317
Loa Loa (eye worm) calcium channel 0.0149 0.0273 0.0273
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0287 0.0654 0.3557
Loa Loa (eye worm) glutamate receptor 0.0073 0.0063 0.0063
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0149 0.0273 0.0733
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0069 0.0053 0.0141
Loa Loa (eye worm) hypothetical protein 0.0268 0.0604 0.0604
Loa Loa (eye worm) hypothetical protein 0.0432 0.1057 0.1057
Brugia malayi photoreceptor-specific nuclear receptor 0.1195 0.317 0.3778
Echinococcus multilocularis short transient receptor potential channel 6 0.0158 0.0299 0.0802
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.1195 0.317 0.317
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Schistosoma mansoni nuclear receptor nhr-48 0.0563 0.1422 0.382
Echinococcus granulosus transient receptor potential cation channel 0.0149 0.0273 0.0733
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0112 0.0171 0.5519
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0149 0.0273 0.0733
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0112 0.0171 0.0459
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0149 0.0273 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0105 0.3155
Schistosoma mansoni nAChR subunit 0.0841 0.2192 0.5888
Echinococcus granulosus transient receptor potential cation channel 0.0149 0.0273 0.0733
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0149 0.0273 0.0733
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Toxoplasma gondii transporter, cation channel family protein 0.0149 0.0273 0.0427
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.1195 0.317 0.8518
Loa Loa (eye worm) hypothetical protein 0.0563 0.1422 0.1422
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Loa Loa (eye worm) hypothetical protein 0.0158 0.0299 0.0299
Brugia malayi Peroxidasin 0.0268 0.0604 0.072
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0465 0.1149 0.3087
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Brugia malayi hypothetical protein 0.0409 0.0995 0.1186
Brugia malayi nuclear receptor NHR-88 0.0563 0.1422 0.1694
Schistosoma mansoni voltage-gated potassium channel 0.0149 0.0273 0.0733
Giardia lamblia Alanyl dipeptidyl peptidase 0.0112 0.0171 0.0194
Brugia malayi ecdysone receptor 0.0563 0.1422 0.1694
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0149 0.0273 0.0325
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0742 0.1918 0.5152
Echinococcus granulosus hyperpolarization activated cyclic 0.0157 0.0295 0.0793
Schistosoma mansoni 60S ribosomal protein L21 0.0154 0.0288 0.0775
Loa Loa (eye worm) hypothetical protein 0.0268 0.0604 0.0604
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0162 0.0311 0.0834
Loa Loa (eye worm) hypothetical protein 0.0646 0.1649 0.1649
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0841 0.2192 0.5888
Echinococcus granulosus ecdysone induced protein 78C 0.1195 0.317 0.8518
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0841 0.2192 0.5888
Echinococcus multilocularis potassium voltage gated channel protein 0.0149 0.0273 0.0733
Echinococcus multilocularis potassium voltage gated channel protein 0.0149 0.0273 0.0733
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Echinococcus multilocularis transient receptor potential cation channel 0.0149 0.0273 0.0733
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0841 0.2192 0.2612
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0157 0.0295 0.0793
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Echinococcus granulosus voltage gated potassium channel 0.0162 0.0311 0.0834
Schistosoma mansoni nuclear receptor 0.0563 0.1422 0.382
Onchocerca volvulus Bile acid receptor homolog 0.1195 0.317 1
Brugia malayi Cadherin domain containing protein 0.0087 0.0101 0.012
Loa Loa (eye worm) hypothetical protein 0.0563 0.1422 0.1422
Brugia malayi Animal haem peroxidase family protein 0.0268 0.0604 0.072
Loa Loa (eye worm) hypothetical protein 0.0432 0.1057 0.1057
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0273 0.0616 0.331
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0149 0.0273 0.0733
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0149 0.0273 0.0325
Onchocerca volvulus 0.0841 0.2192 0.6812
Schistosoma mansoni notch 0.0087 0.0101 0.027
Loa Loa (eye worm) ion channel NompC 0.0149 0.0273 0.0273
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0149 0.0273 0.0325
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0088 0.0105 0.0012
Brugia malayi Niemann-Pick C1 protein precursor 0.009 0.011 0.0131
Loa Loa (eye worm) hypothetical protein 0.267 0.7258 0.7258
Loa Loa (eye worm) hypothetical protein 0.0841 0.2192 0.2192
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0088 0.0105 0.3155
Schistosoma mansoni notch 0.0087 0.0101 0.027
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0688 0.1767 0.4748
Echinococcus granulosus geminin 0.0187 0.0378 0.1015
Entamoeba histolytica hypothetical protein, conserved 0.0112 0.0171 0.1178
Echinococcus multilocularis neurogenic locus notch protein 0.0087 0.0101 0.027
Echinococcus multilocularis fat cadherin tumor suppressor 0.0087 0.0101 0.027
Schistosoma mansoni hypothetical protein 0.0087 0.0101 0.027
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0563 0.1422 0.1694
Loa Loa (eye worm) nuclear receptor NHR-67 0.0563 0.1422 0.1422
Brugia malayi Nuclear hormone receptor family member nhr-25 0.1195 0.317 0.3778
Brugia malayi prolyl oligopeptidase family protein 0.0273 0.0616 0.0735
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0088 0.0105 0.0283
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0157 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0157 0.0295 0.0295
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.1195 0.317 0.3778
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1305 0.3477 0.9341
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0646 0.1649 0.443
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0149 0.0273 0.0733
Schistosoma mansoni thyroid hormone receptor 0.1195 0.317 0.8518
Brugia malayi Nuclear hormone receptor E75 0.0563 0.1422 0.1694
Echinococcus granulosus nuclear receptor 2DBD gamma 0.1195 0.317 0.8518
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0088 0.0105 0.3155
Echinococcus granulosus FTZ F1 alpha 0.1195 0.317 0.8518
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0631 0.1609 0.4323
Echinococcus granulosus voltage gated potassium channel 0.0149 0.0273 0.0733
Loa Loa (eye worm) PDE1B protein 0.0088 0.0105 0.0105
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0088 0.0105 0.3155
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0841 0.2192 0.2612
Echinococcus multilocularis transfer RNA-Gly 0.0149 0.0273 0.0733
Echinococcus multilocularis thyroid hormone receptor alpha 0.1195 0.317 0.8518
Loa Loa (eye worm) hypothetical protein 0.0087 0.0101 0.0101
Echinococcus granulosus ryanodine receptor 44f 0.0149 0.0273 0.0733
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0631 0.1609 0.4323
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0157 0.0295 0.0793
Loa Loa (eye worm) hypothetical protein 0.0631 0.1609 0.1609
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0273 0.0616 0.1656
Schistosoma mansoni retinoid-x-receptor (RXR) 0.1195 0.317 0.8518
Echinococcus multilocularis prolyl endopeptidase 0.0646 0.1649 0.443
Schistosoma mansoni notch 0.0096 0.0127 0.034

Activities

Activity type Activity value Assay description Source Reference
AZT formation (functional) = 0 % Regeneration of the 5,6-Olefinic bond was measured as percent of 3''-azido-3''-deoxythymidine (AZT) formed upon incubation with Glutathione for 30 min at 37 degree C ChEMBL. 7996541
AZT formation (functional) = 0 % In vitro percent of 3''-azido-3''-deoxythymidine (AZT) formed upon incubation with mouse blood for 10 min at 37 degree C ChEMBL. 7996541
AZT formation (functional) = 0 % In vitro percent of 3''-azido-3''-deoxythymidine (AZT) formed upon incubation with mouse liver homogenate for 30 min at 37 degree C ChEMBL. 7996541
AZT formation (functional) = 0 % In vitro percent of 3''-azido-3''-deoxythymidine (AZT) formed upon incubation with mouse blood for 10 min at 37 degree C ChEMBL. 7996541
AZT formation (functional) = 0 % In vitro percent of 3''-azido-3''-deoxythymidine (AZT) formed upon incubation with mouse liver homogenate for 30 min at 37 degree C ChEMBL. 7996541
EC50 (functional) 0 M Effective concentration (in vitro anti-HIV activity ) which produces a 50% survival of HIV-1-infected CEM cells relative to uninfected untreated controls; ND=Not determined ChEMBL. 7996541
IC50 (functional) 0 M Inhibitory concentration (cytotoxic activity) which results in a 50% survival of HIV-1-infected CEM cells relative to uninfected untreated control cells; ND=Not determined ChEMBL. 7996541
Ki (functional) > 1.5 mM Thymidine Influx Inhibition constant for the compound in fresh Murine Erythrocytes ChEMBL. 8632406
Ki (functional) > 1.5 mM Thymidine Influx Inhibition constant for the compound in fresh Murine Erythrocytes ChEMBL. 8632406
P = 3.3 Concentration in 1-octanol / concentration in water ChEMBL. 7996541
Partition coefficient = 3.3 Partition coefficient of the compound for 1-octanol/water was evaluated ChEMBL. 8632406
Phosphorolysis (functional) = 0 % In vitro percent of phosphorolysis after incubation with E. coli thymidine phosphorylase for 10 min at 37 degree C ChEMBL. 7996541
Phosphorolysis (functional) = 0 % In vitro percent of phosphorolysis after incubation with E. coli thymidine phosphorylase for 10 min at 37 degree C ChEMBL. 7996541
TI (functional) 0 Therapeutic index of IC50 to EC50; ND=Not determined ChEMBL. 7996541

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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