TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 403.313 | Formula: C6H12N2O4PtS-
H donors: 2 H acceptors: 3 LogP: -2.55 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: [O-]S(=O)(=O)O[Pt]1NC2[C@H](N1)CCCC2
InChi: 1S/C6H12N2.H2O4S.Pt/c7-5-3-1-2-4-6(5)8;1-5(2,3)4;/h5-8H,1-4H2;(H2,1,2,3,4);/q-2;;+3/p-2/t5-,6?;;/m0../s1
InChiKey: NSBPLNFTFWFNBO-ANJCWRQCSA-L

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Chlamydia trachomatis	dihydrofolate reductase	0.0523	0.5858	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Leishmania major	hypothetical protein, conserved	0.0042	0.0288	0.0928
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0032	0.0178	0.0369
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0523	0.5858	1
Onchocerca volvulus		0.0061	0.0512	1
Entamoeba histolytica	hypothetical protein	0.0042	0.0292	0.0629
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0088	0.0826	0.2666
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0225	0.0384
Brugia malayi	Dihydrofolate reductase	0.0523	0.5858	1
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0088	0.0826	0.2666
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0053	0.0418	0.0713
Schistosoma mansoni	DNA helicase recq1	0.002	0.0036	0.0062
Trichomonas vaginalis	sugar transporter, putative	0.0134	0.1363	0.2667
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0042	0.0296	0.0612
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0284	0.3098	0.529
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0284	0.3098	1
Plasmodium falciparum	hexose transporter	0.0434	0.4827	1
Brugia malayi	Major Facilitator Superfamily protein	0.0061	0.0512	0.0875
Loa Loa (eye worm)	RNA binding protein	0.0067	0.0584	0.0997
Onchocerca volvulus		0.0061	0.0512	1
Onchocerca volvulus		0.0061	0.0512	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0418	0.0713
Brugia malayi	Sugar transporter family protein	0.0434	0.4827	0.8241
Trypanosoma brucei	glucose transporter, putative	0.0134	0.1363	0.44
Trypanosoma brucei	glucose transporter, putative	0.0134	0.1363	0.44
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0284	0.3098	1
Trichomonas vaginalis	DNA helicase recq, putative	0.0048	0.0363	0.0549
Schistosoma mansoni	glucose transport protein	0.0434	0.4827	0.8241
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0134	0.1363	0.44
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.002	0.0036	0.0036
Mycobacterium ulcerans	glyceraldehyde 3-phosphate dehydrogenase Gap	0.0284	0.3098	0.5046
Schistosoma mansoni	sugar transporter	0.0061	0.0512	0.0875
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0288	0.0491
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0292	0.0292
Wolbachia endosymbiont of Brugia malayi	glyceraldehyde-3-phosphate dehydrogenase, GapA	0.0284	0.3098	1
Schistosoma mansoni	blooms syndrome DNA helicase	0.0038	0.0246	0.042
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0288	0.0491
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0288	0.0389
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0288	0.0928
Toxoplasma gondii	sugar transporter ST3	0.0061	0.0512	0.1061
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0036	0.0074
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Plasmodium vivax	hexose transporter	0.0434	0.4827	1
Echinococcus granulosus	solute carrier family 22	0.0061	0.0512	0.0875
Onchocerca volvulus		0.0061	0.0512	1
Echinococcus multilocularis	geminin	0.0196	0.2072	0.2072
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0584	0.0997
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0061	0.0512	0.0875
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0284	0.3098	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0418	0.0714
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0434	0.4827	0.4827
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0418	0.0714
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0434	0.4827	0.4827
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0061	0.0512	0.0875
Trichomonas vaginalis	glucose transporter, putative	0.0061	0.0512	0.0865
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.02	0.212	0.6842
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0284	0.3098	0.3098
Brugia malayi	isocitrate dehydrogenase	0.0017	0	0.0001
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, cytosolic	0.0284	0.3098	1
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Trypanosoma brucei	sugar transporter, putative	0.0061	0.0512	0.1653
Echinococcus multilocularis	General substrate transporter	0.0373	0.4121	0.4121
Brugia malayi	RNA binding protein	0.0067	0.0584	0.0997
Toxoplasma gondii	sugar transporter ST1	0.0061	0.0512	0.1061
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0284	0.3098	0.634
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.0288	0.0491
Brugia malayi	major facilitator superfamily protein	0.0061	0.0512	0.0875
Onchocerca volvulus		0.0061	0.0512	1
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0186	0.1963	0.3352
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0584	0.0997
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0584	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0266	0.2882	0.492
Loa Loa (eye worm)	hypothetical protein	0.002	0.0036	0.0062
Brugia malayi	beta-lactamase	0.0042	0.0288	0.0491
Leishmania major	hypothetical protein, conserved	0.0061	0.0512	0.1653
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0061	0.0512	0.0874
Trichomonas vaginalis	sugar transporter, putative	0.0134	0.1363	0.2667
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0061	0.0512	0.0512
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0288	0.0491
Trypanosoma brucei	glucose transporter, putative	0.0134	0.1363	0.44
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.02	0.212	0.4391
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0284	0.3098	1
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0098	0.0942	0.1774
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0434	0.4827	0.4827
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1963	0.3352
Loa Loa (eye worm)	MH2 domain-containing protein	0.013	0.1307	0.2231
Brugia malayi	hypothetical protein	0.0061	0.0512	0.0875
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0284	0.3098	0.634
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0284	0.3098	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0288	0.0491
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0434	0.4827	0.8241
Schistosoma mansoni	glucose transporter	0.0061	0.0512	0.0875
Schistosoma mansoni	hypothetical protein	0.0196	0.2072	0.3537
Schistosoma mansoni	hypothetical protein	0.0196	0.2072	0.3537
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0033	0.0183	0.0378
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0284	0.3098	1
Schistosoma mansoni	hypothetical protein	0.0042	0.0292	0.0499
Plasmodium vivax	sugar transporter, putative	0.0061	0.0512	0.1061
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0288	0.0491
Trichomonas vaginalis	sugar transporter, putative	0.0134	0.1363	0.2667
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.0584	0.0997
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0186	0.1963	0.3352
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0512	0.0865
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Echinococcus multilocularis	bloom syndrome protein	0.0048	0.0363	0.0363
Trichomonas vaginalis	DNA helicase recq1, putative	0.0048	0.0363	0.0549
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0186	0.1963	0.1963
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0284	0.3098	1
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0186	0.1961	0.633
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0288	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0288	0.0491
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.002	0.0036	0.0062
Onchocerca volvulus		0.0061	0.0512	1
Trypanosoma cruzi	hexose transporter, putative	0.0134	0.1363	0.44
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0288	0.0928
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0061	0.0512	0.0403
Mycobacterium ulcerans	integral membrane transport protein	0.0061	0.0512	0.0403
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.002	0.0036	0.0074
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Toxoplasma gondii	ABC1 family protein	0.0042	0.0288	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0512	0.0865
Leishmania major	glyceraldehyde-3-phosphate dehydrogenase-like protein	0.0186	0.1961	0.633
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0288	0.0491
Giardia lamblia	Hexose transporter	0.0061	0.0512	0.1555
Trichomonas vaginalis	sugar transport protein, putative	0.0061	0.0512	0.0865
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Echinococcus multilocularis	solute carrier family 22	0.0061	0.0512	0.0512
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0288	0.0491
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0134	0.1363	0.44
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0288	0.0491
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0098	0.0942	0.1607
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0288	0.0389
Trichomonas vaginalis	glucose transporter, putative	0.0134	0.1363	0.2667
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0288	0.0491
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0512	0.0865
Echinococcus granulosus	synaptic vesicle 2 protein	0.0061	0.0512	0.0875
Trichomonas vaginalis	conserved hypothetical protein	0.0134	0.1363	0.2667
Schistosoma mansoni	sugar transporter	0.0061	0.0512	0.0875
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0523	0.5858	1
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.0196	0.2079	0.3548
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0288	0.0389
Onchocerca volvulus	Putative transporter	0.0061	0.0512	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Brugia malayi	hypothetical protein	0.0061	0.0512	0.0875
Leishmania major	myo-inositol/proton symporter (MIT)	0.0061	0.0512	0.1653
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0284	0.3098	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0	0.0001
Schistosoma mansoni	glucose transport protein	0.0434	0.4827	0.8241
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0292	0.0499
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.0584	0.0997
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Onchocerca volvulus		0.0061	0.0512	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0288	0.0491
Treponema pallidum	glyceraldehyde 3-phosphate dehydrogenase (gap)	0.0284	0.3098	0.5
Trypanosoma brucei	glucose transporter, putative	0.0134	0.1363	0.44
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0284	0.3098	0.529
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0584	0.0997
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.002	0.0036	0.0036
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.0288	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Echinococcus granulosus	General substrate transporter	0.0373	0.4121	0.7036
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0036	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0418	0.0418
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0288	0.0389
Mycobacterium leprae	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0098	0.0943	0.1177
Leishmania major	glucose transporter, lmgt3	0.0134	0.1363	0.44
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0061	0.0512	0.1061
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0288	0.0491
Echinococcus multilocularis	solute carrier family 22	0.0061	0.0512	0.0512
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0284	0.3098	1
Schistosoma mansoni	DNA helicase recq5	0.002	0.0036	0.0062
Brugia malayi	glyceraldehyde 3-phosphate dehydrogenase	0.0088	0.0826	0.141
Brugia malayi	Sugar transporter family protein	0.0061	0.0512	0.0875
Onchocerca volvulus		0.0061	0.0512	1
Loa Loa (eye worm)	transcription factor SMAD2	0.013	0.1307	0.2231
Echinococcus granulosus	geminin	0.0196	0.2072	0.3537
Schistosoma mansoni	dihydrofolate reductase	0.0523	0.5858	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0061	0.0512	0.0875
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Plasmodium falciparum	glyceraldehyde-3-phosphate dehydrogenase	0.0284	0.3098	0.6418
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.0288	0.0491
Onchocerca volvulus		0.0061	0.0512	1
Toxoplasma gondii	transporter, major facilitator family protein	0.0061	0.0512	0.1061
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0061	0.0512	0.1653
Brugia malayi	TAR-binding protein	0.0067	0.0584	0.0997
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0584	0.0997
Brugia malayi	Major Facilitator Superfamily protein	0.0061	0.0512	0.0875
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0088	0.0826	0.2666
Echinococcus granulosus	solute carrier family 22	0.0061	0.0512	0.0875
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0434	0.4827	0.4827
Trypanosoma brucei	glucose transporter, putative	0.0134	0.1363	0.44
Toxoplasma gondii	sugar transporter ST2	0.0061	0.0512	0.1061
Trypanosoma cruzi	hexose transporter	0.0134	0.1363	0.44
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0418	0.0713
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0418	0.0714
Trypanosoma brucei	glucose transporter, putative	0.0134	0.1363	0.44
Onchocerca volvulus		0.0061	0.0512	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.0288	0.0491
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Onchocerca volvulus		0.0061	0.0512	1
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Schistosoma mansoni	hypothetical protein	0.0036	0.0225	0.0384
Trypanosoma cruzi	hexose transporter, putative	0.0061	0.0512	0.1653
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0088	0.0826	0.2666
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.0288	0.0491
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0288	0.0491
Schistosoma mansoni	hypothetical protein	0.0434	0.4827	0.8241
Echinococcus granulosus	tar DNA binding protein	0.0067	0.0584	0.0997
Schistosoma mansoni	sugar transporter	0.0061	0.0512	0.0875
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0186	0.1963	0.3352
Entamoeba histolytica	hypothetical protein	0.0042	0.0292	0.0629
Trypanosoma cruzi	sugar transporter, putative	0.0061	0.0512	0.1653
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0284	0.3098	0.529
Echinococcus granulosus	dihydrofolate reductase	0.0523	0.5858	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Brugia malayi	Sugar transporter family protein	0.0061	0.0512	0.0875
Trichomonas vaginalis	conserved hypothetical protein	0.0134	0.1363	0.2667
Trichomonas vaginalis	myo-inositol transporter, putative	0.0061	0.0512	0.0865
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0036	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0512	0.0865
Brugia malayi	major facilitator superfamily protein	0.0061	0.0512	0.0875
Onchocerca volvulus		0.0061	0.0512	1
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Schistosoma mansoni	sugar transporter	0.0061	0.0512	0.0875
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0036	0.0062
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH2	0.0284	0.3098	0.6418
Loa Loa (eye worm)	sugar transporter	0.0434	0.4827	0.8241
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0292	0.0499
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0134	0.1363	0.44
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0061	0.0512	0.0512
Giardia lamblia	Sugar-proton symporter	0.0061	0.0512	0.1555
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0288	0.0389
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.02	0.212	0.6842
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0284	0.3098	0.634
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.02	0.212	0.4391
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.0584	0.0997
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.0196	0.2079	0.3548
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0186	0.1961	0.6287
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0523	0.5858	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0434	0.4827	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1499	0.2559
Leishmania major	glucose transporter, lmgt1	0.0134	0.1363	0.44
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0061	0.0512	0.0874
Brugia malayi	beta-lactamase family protein	0.0042	0.0288	0.0491
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0	0.0001
Trypanosoma cruzi	hexose transporter, putative	0.0073	0.0657	0.2121
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0284	0.3098	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0434	0.4827	0.8241
Trypanosoma brucei	glucose transporter, putative	0.0134	0.1363	0.44
Entamoeba histolytica	hypothetical protein	0.0042	0.0292	0.0629
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0418	0.0713
Brugia malayi	Bloom's syndrome protein homolog	0.0048	0.0363	0.062
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0061	0.0512	0.0875
Echinococcus multilocularis	solute carrier family 22	0.0061	0.0512	0.0512
Plasmodium vivax	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0284	0.3098	0.6418
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Brugia malayi	MH2 domain containing protein	0.013	0.1307	0.2231
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Onchocerca volvulus		0.0061	0.0512	1
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.02	0.212	0.4391
Echinococcus multilocularis	dihydrofolate reductase	0.0523	0.5858	0.5858
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0284	0.3098	0.3098
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.002	0.0036	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0418	0.0714
Echinococcus multilocularis	solute carrier family 22	0.0061	0.0512	0.0512
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0512	0.0865
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.02	0.212	0.6842
Echinococcus granulosus	bloom syndrome protein	0.0048	0.0363	0.062
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0061	0.0512	0.0403
Schistosoma mansoni	glucose transport protein	0.0434	0.4827	0.8241
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0026	0.0104	0.0334
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0053	0.0418	0.0713
Brugia malayi	hypothetical protein	0.0061	0.0512	0.0875
Brugia malayi	beta-lactamase family protein	0.0042	0.0288	0.0491
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0225	0.0384
Brugia malayi	dihydrofolate reductase family protein	0.0523	0.5858	1
Mycobacterium ulcerans	sugar transporter	0.0061	0.0512	0.0403
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0186	0.1963	0.3936
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.0584	0.0584
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0288	0.0288
Trichomonas vaginalis	conserved hypothetical protein	0.0434	0.4827	1
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0284	0.3098	0.634
Echinococcus granulosus	solute carrier family 22	0.0061	0.0512	0.0875
Trypanosoma brucei	glucose transporter 1E	0.0134	0.1363	0.44
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0434	0.4827	0.8241
Trypanosoma brucei	glucose transporter, putative	0.0134	0.1363	0.44
Trichomonas vaginalis	glucose transporter, putative	0.0134	0.1363	0.2667
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0284	0.3098	1
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0284	0.3098	0.529
Trypanosoma cruzi	glucose transporter, putative	0.0061	0.0512	0.1653
Brugia malayi	Isocitrate dehydrogenase	0.0017	0	0.0001
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0284	0.3098	1
Loa Loa (eye worm)	RecQ helicase	0.0048	0.0363	0.062
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Entamoeba histolytica	hypothetical protein	0.0042	0.0292	0.0629
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.002	0.0036	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0288	0.0491
Trypanosoma cruzi	hexose transporter, putative	0.0134	0.1363	0.44
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0088	0.0826	0.2666
Trypanosoma brucei	glucose transporter 2A	0.0134	0.1363	0.44
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.0288	0.0491
Onchocerca volvulus		0.0061	0.0512	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0026	0.0104	0.0334
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0186	0.1961	0.633
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0053	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Leishmania major	glucose transporter, lmgt2	0.0134	0.1363	0.44
Loa Loa (eye worm)	dihydrofolate reductase	0.0523	0.5858	1
Onchocerca volvulus		0.0061	0.0512	1
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0284	0.3098	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0288	0.0928
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0026	0.0104	0.0334
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0284	0.3098	0.529
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0053	0.0418	0.0713
Brugia malayi	Major Facilitator Superfamily protein	0.0061	0.0512	0.0875
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0284	0.3098	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0053	0.0418	0.0713
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0284	0.3098	0.529
Trichomonas vaginalis	sugar transporter, putative	0.0061	0.0512	0.0865
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.0288	0.0491
Echinococcus granulosus	solute carrier family 22	0.0061	0.0512	0.0875
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0284	0.3098	0.529
Loa Loa (eye worm)	sugar transporter	0.0061	0.0512	0.0875
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0284	0.3098	1
Brugia malayi	hypothetical protein	0.0042	0.0292	0.0499
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0288	0.0491
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0434	0.4827	0.8241
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0284	0.3098	0.634
Trypanosoma cruzi	hexose transporter, putative	0.0134	0.1363	0.44
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0186	0.1963	0.3936
Trypanosoma brucei	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0186	0.1961	0.633
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0512	0.0875
Mycobacterium tuberculosis	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0098	0.0943	0.161
Trichomonas vaginalis	esterase, putative	0.0042	0.0288	0.0389
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH1	0.0284	0.3098	0.6418
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0	0.0001
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0134	0.1363	0.44
Onchocerca volvulus		0.0061	0.0512	1

Activities

Activity type	Activity value	Assay description	Source	Reference
MED (functional)	= 0.39 mg kg-1	Minimum effective dose (MED) against leukemia P388 in CDF1 mice	ChEMBL.	7241508
Optimal dose (functional)	= 6.25 mg kg-1	Optimal dose of the compound against leukemia P388 in CDF1 mice	ChEMBL.	7241508
T/C (functional)	= 124 %	Antitumor activity against leukemia P388 in CDF1 mice	ChEMBL.	7241508
T/C (functional)	= 200 %	Antitumor activity against leukemia P388 in CDF1 mice	ChEMBL.	7241508
TI (ADMET)	= 16	Therapeutic index was determined against leukemia P388 cells in mice	ChEMBL.	7241508
Toxic dose (functional)	= 25 mg kg-1	Toxic dose against leukemia P388 in CDF1 mice	ChEMBL.	7241508

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 346774

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 254891