Detailed information for compound 255247

Basic information

Technical information
  • TDR Targets ID: 255247
  • Name: (2-azanidylcyclohexyl)azanide; dibromoplatinu m(2+)
  • MW: 467.059 | Formula: C6H12Br2N2Pt
  • H donors: 2 H acceptors: 0 LogP: 2.61 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Br[Pt]1(Br)NC2C(N1)CCCC2
  • InChi: 1S/C6H12N2.2BrH.Pt/c7-5-3-1-2-4-6(5)8;;;/h5-8H,1-4H2;2*1H;/q-2;;;+4/p-2
  • InChiKey: VURFXQDFACAVRZ-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

  • (2-amidylcyclohexyl)azanide; dibromoplatinum(2+)
  • (2-azanidylcyclohexyl)azanide; dibromoplatinum
  • 67225-25-6
  • 67225-26-7
  • 67225-24-5
  • NSC289759
  • 1,2-Cyclohexanediamine, platinum dibromide complex,(1S:trans)-
  • NSC289558
  • Platinum, dibromo(1,2-cyclohexanediamine-N,N')-,(SP-4-2) (1S:trans)-
  • 1,2-Cyclohexanediamine, platinum dibromide complex,(1R-trans)-
  • NSC289559
  • Platinum, dibromo(1,2-cyclohexanediamine-N,N')-,(SP-4-2), (1R-trans)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0019 0.0031 0.0027
Echinococcus multilocularis Ankyrin 0.0015 0.0014 0.0013
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0082 0.055
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0379 0.1565 0.2404
Brugia malayi Cytochrome P450 family protein 0.0016 0.002 0.001
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0077 0.0141
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0086 1
Mycobacterium ulcerans phosphomevalonate kinase 0.0019 0.0028 0.0465
Leishmania major mevalonate kinase, putative 0.0019 0.0028 0.0224
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0077 0.0141
Echinococcus granulosus KRAB A domain containing protein 0.003 0.0077 0.0141
Schistosoma mansoni rab6-interacting 0.0019 0.0031 0.0027
Schistosoma mansoni intermediate filament proteins 0.0028 0.0069 0.0087
Brugia malayi Integrin alpha pat-2 precursor 0.1528 0.6469 1
Brugia malayi hypothetical protein 0.003 0.0077 0.0099
Echinococcus multilocularis RUN 0.0019 0.0031 0.0048
Giardia lamblia Ribonuclease H 0.031 0.1271 1
Echinococcus multilocularis RNA directed DNA polymerase 0.003 0.0077 0.0141
Echinococcus granulosus intermediate filament protein 0.0028 0.0069 0.0125
Echinococcus multilocularis lamin 0.0028 0.0069 0.0125
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.003 0.0077 0.0606
Echinococcus granulosus galactokinase 0.006 0.0207 0.0405
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.031 0.1271 1
Loa Loa (eye worm) RecQ helicase 0.0022 0.0044 0.0039
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0102 0.08
Leishmania major phosphomevalonate kinase protein, putative 0.0019 0.0028 0.0224
Echinococcus granulosus ribonuclease H1 0.031 0.1271 0.2557
Echinococcus granulosus integrin alpha 3 0.1172 0.4947 1
Brugia malayi Cytochrome P450 family protein 0.0016 0.002 0.001
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.002 0.0155
Trypanosoma brucei ingi protein (ORF1) 0.034 0.1398 0.2506
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0077 0.0141
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0077 0.0141
Trypanosoma brucei mevalonate kinase, putative 0.0019 0.0028 0.0051
Loa Loa (eye worm) hypothetical protein 0.0028 0.0069 0.0064
Schistosoma mansoni mevalonate kinase 0.0019 0.0028 0.0024
Echinococcus granulosus death domain containing protein 0.0015 0.0013 0.0012
Brugia malayi Death domain containing protein 0.0015 0.0013 0.000000014319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0082 0.0106
Trichomonas vaginalis galactokinase, putative 0.0028 0.007 0.0548
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.003 0.0077 0.0391
Schistosoma mansoni phosphoglucomutase 0.031 0.1271 0.1948
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.0435 0.0867
Schistosoma mansoni lipoxygenase 0.008 0.0289 0.0428
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0031 0.0048
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0077 0.0099
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0102 0.0707
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0031 0.2522
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0044 0.0048
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0031 0.0048
Echinococcus granulosus bloom syndrome protein 0.0022 0.0044 0.0075
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0069 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0026
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0077 0.0099
Brugia malayi DOMON domain containing protein 0.0143 0.0559 0.0845
Echinococcus multilocularis integrin alpha ps 0.0685 0.2872 0.58
Schistosoma mansoni polycystin 1-related 0.0019 0.0031 0.0027
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0077 0.0099
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0077 0.0141
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.003 0.0077 0.0507
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0082 0.0106
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0031 0.0048
Echinococcus granulosus N acetylgalactosamine kinase 0.0028 0.007 0.0126
Trichomonas vaginalis reverse transcriptases, putative 0.003 0.0077 0.0606
Loa Loa (eye worm) hypothetical protein 0.0028 0.0067 0.0062
Onchocerca volvulus 0.0028 0.0069 0.0444
Toxoplasma gondii GHMP kinase, putative 0.0019 0.0028 0.0125
Toxoplasma gondii ribonuclease HI protein 0.031 0.1271 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0044 0.0347
Giardia lamblia Reverse transcriptase/endonuclease 0.003 0.0077 0.0391
Onchocerca volvulus Ribonuclease H1 homolog 0.031 0.1271 1
Echinococcus multilocularis integrin alpha ps 0.0685 0.2872 0.58
Onchocerca volvulus 0.0031 0.0082 0.0546
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.003 0.0077 0.0141
Loa Loa (eye worm) inositol-1 0.0036 0.0102 0.0097
Echinococcus granulosus lamin 0.0028 0.0069 0.0125
Trypanosoma brucei galactokinase-like protein, putative 0.004 0.0121 0.0217
Loa Loa (eye worm) hypothetical protein 0.0746 0.3133 0.313
Loa Loa (eye worm) hypothetical protein 0.1156 0.4881 0.4879
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0102 0.4899
Trypanosoma cruzi galactokinase, putative 0.006 0.0207 0.1633
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0077 0.0099
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0031 0.0048
Schistosoma mansoni inositol monophosphatase 0.0036 0.0102 0.0137
Echinococcus multilocularis integrin alpha 3 0.1172 0.4947 1
Trypanosoma cruzi homoserine kinase 0.0019 0.0028 0.0224
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0746 0.3133 0.6327
Onchocerca volvulus 0.0019 0.0031 0.0139
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.003 0.0077 0.0138
Mycobacterium tuberculosis Possible maturase 0.003 0.0077 0.271
Brugia malayi Protein kinase domain containing protein 0.0015 0.0013 0.000000014319
Schistosoma mansoni lipoxygenase 0.0114 0.0435 0.0654
Mycobacterium ulcerans 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0019 0.0028 0.0465
Schistosoma mansoni integrin alpha 0.1528 0.6469 1
Trichomonas vaginalis ribonuclease H1, putative 0.031 0.1271 1
Brugia malayi galactokinase family protein 0.0028 0.007 0.0087
Trichomonas vaginalis galactokinase, putative 0.0028 0.007 0.0548
Echinococcus granulosus nuclear factor of activated T cells 5 0.0077 0.0276 0.0544
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0102 0.08
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.003 0.0077 0.0141
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.003 0.0077 0.0141
Loa Loa (eye worm) DOMON domain-containing protein 0.0143 0.0559 0.0554
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0077 0.0099
Brugia malayi RNase H family protein 0.031 0.1271 0.1948
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.0987 0.0982
Echinococcus granulosus lamin dm0 0.0028 0.0069 0.0125
Trypanosoma brucei cytochrome P450, putative 0.0016 0.002 0.0035
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0746 0.3133 0.4832
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0082 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0082 0.0106
Brugia malayi RNase H family protein 0.031 0.1271 0.1948
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0023
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0102 0.0182
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.003 0.0077 0.0391
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0746 0.3133 0.6327
Echinococcus multilocularis Mevalonate galactokinase 0.0019 0.0028 0.0043
Brugia malayi Uncoordinated protein 44 0.0015 0.0013 0.000000014319
Loa Loa (eye worm) hypothetical protein 0.0328 0.135 0.1346
Trypanosoma cruzi ribonuclease H1, putative 0.031 0.1271 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0009
Brugia malayi Pre-SET motif family protein 0.0216 0.0873 0.1331
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0014 0.0009
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0013 0.0008
Schistosoma mansoni dopamine-beta-monooxygenase 0.1413 0.5977 0.9238
Schistosoma mansoni galactokinase 0.0028 0.007 0.0087
Echinococcus multilocularis integrin alpha ps 0.0328 0.135 0.2719
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0013 0.0012
Brugia malayi Inositol-1 0.0036 0.0102 0.0137
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0102 0.08
Trypanosoma brucei phosphomevalonate kinase protein, putative 0.0019 0.0028 0.0051
Echinococcus multilocularis N acetylgalactosamine kinase 0.0028 0.007 0.0126
Trypanosoma brucei homoserine kinase 0.0019 0.0028 0.0051
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0102 0.4364
Trichomonas vaginalis galactokinase, putative 0.0028 0.007 0.0548
Loa Loa (eye worm) DOMON domain-containing protein 0.0143 0.0559 0.0554
Onchocerca volvulus 0.003 0.0077 0.0507
Schistosoma mansoni inositol monophosphatase 0.0036 0.0102 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0082 0.0106
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0077 0.0099
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0102 0.0191
Trypanosoma cruzi ribonuclease H1, putative 0.031 0.1271 1
Loa Loa (eye worm) hypothetical protein 0.0843 0.3546 0.3543
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.034 0.1398 0.2506
Brugia malayi DOMON domain containing protein 0.0143 0.0559 0.0845
Brugia malayi Doublecortin family protein 0.0019 0.0031 0.0027
Schistosoma mansoni hypothetical protein 0.0328 0.135 0.2071
Brugia malayi Pre-SET motif family protein 0.0031 0.0082 0.0106
Brugia malayi follicle stimulating hormone receptor 0.0243 0.0987 0.1508
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0013 0.000000014319
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0077 0.0099
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.003 0.0077 0.0606
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1156 0.4881 0.754
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0077 0.0141
Loa Loa (eye worm) hypothetical protein 0.12 0.5068 0.5066
Trypanosoma cruzi homoserine kinase 0.0019 0.0028 0.0224
Schistosoma mansoni hypothetical protein 0.132 0.5579 0.8621
Leishmania major homoserine kinase, putative 0.0019 0.0028 0.0224
Mycobacterium ulcerans mevalonate kinase, Erg12 0.0019 0.0028 0.0465
Schistosoma mansoni hypothetical protein 0.003 0.0077 0.0099
Brugia malayi reverse transcriptase 0.003 0.0077 0.0099
Schistosoma mansoni phosphoglucomutase 0.031 0.1271 0.1948
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.0873 0.0868
Mycobacterium ulcerans homoserine kinase 0.0019 0.0028 0.0465
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0102 0.08
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0746 0.3133 0.4832
Trichomonas vaginalis galactokinase, putative 0.0028 0.007 0.0548
Echinococcus granulosus integrin alpha ps 0.0685 0.2872 0.58
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0082 0.0151
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0008
Plasmodium vivax SET domain protein, putative 0.0031 0.0082 1
Onchocerca volvulus 0.0143 0.0559 0.434
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0368 0.1517 0.233
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.003 0.0077 0.0391
Brugia malayi Zinc knuckle family protein 0.003 0.0077 0.0099
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0069 0.0087
Loa Loa (eye worm) hypothetical protein 0.0357 0.1471 0.1467
Schistosoma mansoni hypothetical protein 0.0019 0.0031 0.0027
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0013 0.0012
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.0435 0.0867
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0014 0.0001
Schistosoma mansoni integrin alpha-ps 0.0357 0.1471 0.2258
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0002
Loa Loa (eye worm) DOMON domain-containing protein 0.0143 0.0559 0.0554
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0077 0.0141
Brugia malayi hypothetical protein 0.003 0.0077 0.0099
Entamoeba histolytica galactokinase, putative 0.006 0.0207 1
Brugia malayi hypothetical protein 0.0019 0.0031 0.0027
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0044 0.0347
Schistosoma mansoni scy1(yeast) protein kinase-like 0.003 0.0077 0.0099
Loa Loa (eye worm) hypothetical protein 0.0746 0.3133 0.313
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0013 0.0012
Brugia malayi DOMON domain containing protein 0.0143 0.0559 0.0845
Schistosoma mansoni lamin 0.0028 0.0069 0.0087
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0031 0.0048
Trichomonas vaginalis reverse transcriptases, putative 0.003 0.0077 0.0606
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.002 0.0015
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0031 0.0048
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0102 0.08
Brugia malayi reverse transcriptase 0.003 0.0077 0.0099
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0077 0.0099
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0044 0.0075
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0077 0.0141
Trypanosoma brucei unspecified product 0.034 0.1398 0.2506
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0024 0.0017
Schistosoma mansoni phosphoglucomutase 0.031 0.1271 0.1948
Onchocerca volvulus 0.0246 0.1001 0.7854
Brugia malayi RNase H family protein 0.031 0.1271 0.1948
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0077 0.0099
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.002 0.0155
Brugia malayi intermediate filament protein 0.0028 0.0069 0.0087
Onchocerca volvulus 0.003 0.0077 0.0507
Echinococcus granulosus Mevalonate galactokinase 0.0019 0.0028 0.0043
Trypanosoma cruzi galactokinase, putative 0.0053 0.0174 0.1369
Leishmania major ribonuclease H1, putative 0.031 0.1271 1
Trypanosoma cruzi galactokinase-like protein, putative 0.0053 0.0174 0.1369
Trypanosoma brucei SLACS reverse transcriptase, putative 0.003 0.0077 0.0138
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0077 0.0099
Treponema pallidum galactokinase 0.0053 0.0174 0.1172
Echinococcus granulosus RUN 0.0019 0.0031 0.0048
Treponema pallidum ribonuclease H (rnhA) 0.031 0.1271 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0077 0.0606
Echinococcus multilocularis galactokinase 0.006 0.0207 0.0405
Leishmania major galactokinase-like protein 0.006 0.0207 0.1633
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.003 0.0077 0.0141
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0013 0.0012
Echinococcus multilocularis ribonuclease H1 0.031 0.1271 0.2557
Echinococcus granulosus integrin alpha ps 0.0328 0.135 0.2719
Schistosoma mansoni peptidylglycine monooxygenase 0.0746 0.3133 0.4832
Echinococcus granulosus Ankyrin 0.0015 0.0014 0.0013
Schistosoma mansoni integrin alpha-ps 0.0685 0.2872 0.4429
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.003 0.0077 0.0141
Trypanosoma cruzi galactokinase, putative 0.006 0.0207 0.1633
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0082 0.0151
Brugia malayi mevalonate kinase family protein 0.0019 0.0028 0.0024
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0077 0.0276 0.0544
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0102 0.0191
Trypanosoma brucei ribonuclease H1 0.031 0.1271 0.2277
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.003 0.0077 0.0391
Leishmania major cytochrome p450-like protein 0.0016 0.002 0.0155
Loa Loa (eye worm) hypothetical protein 0.0031 0.0082 0.0077
Echinococcus multilocularis lamin dm0 0.0028 0.0069 0.0125
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0077 0.0099
Schistosoma mansoni lamin 0.0028 0.0069 0.0087
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.002 0.0015
Schistosoma mansoni rab6-interacting 0.0019 0.0031 0.0027
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0086 0.3198
Mycobacterium tuberculosis Probable galactokinase GalK (galactose kinase) 0.006 0.0207 1
Schistosoma mansoni hypothetical protein 0.003 0.0077 0.0099
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0031 0.0026
Onchocerca volvulus 0.0028 0.0069 0.0444
Brugia malayi reverse transcriptase 0.003 0.0077 0.0099
Toxoplasma gondii GHMP kinase, N-terminal domain-containing protein 0.0028 0.007 0.0452
Trypanosoma cruzi mevalonate kinase, putative 0.0019 0.0028 0.0224
Onchocerca volvulus 0.0019 0.0031 0.0139
Loa Loa (eye worm) galactokinase 0.0028 0.007 0.0065
Schistosoma mansoni loxhd1 0.0019 0.0031 0.0027
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0746 0.3133 0.4832
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0077 0.0141
Trypanosoma brucei ingi protein (ORF1) 0.034 0.1398 0.2506
Brugia malayi hypothetical protein 0.003 0.0077 0.0099
Brugia malayi Zinc knuckle family protein 0.003 0.0077 0.0099
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0033 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0069 0.0064
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0077 0.0099
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.002
Loa Loa (eye worm) CYP4Cod1 0.0016 0.002 0.0015
Echinococcus granulosus RNA directed DNA polymerase 0.003 0.0077 0.0141
Trypanosoma brucei RNA helicase, putative 0.132 0.5579 1
Mycobacterium ulcerans galactokinase 0.006 0.0207 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0102 0.0589
Echinococcus multilocularis musashi 0.0028 0.0069 0.0125
Schistosoma mansoni protein kinase 0.003 0.0077 0.0099
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.003 0.0077 0.0138
Brugia malayi hypothetical protein 0.003 0.0077 0.0099
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0077 0.0099
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0077 0.0099
Trypanosoma brucei hypothetical protein, conserved 0.034 0.1398 0.2506
Brugia malayi Pao retrotransposon peptidase family protein 0.003 0.0077 0.0099
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.003 0.0077 0.0141
Trichomonas vaginalis set domain proteins, putative 0.0246 0.1 0.7872
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0102 0.08
Onchocerca volvulus 0.0143 0.0559 0.434

Activities

Activity type Activity value Assay description Source Reference
MED (functional) = 1.56 mg kg-1 Minimum effective dose (MED) against leukemia P388 in CDF1 mice ChEMBL. 7241508
Optimal dose (functional) = 25 mg kg-1 Optimal dose of the compound against leukemia P388 in CDF1 mice ChEMBL. 7241508
T/C (functional) = 126 % Antitumor activity against leukemia P388 in CDF1 mice ChEMBL. 7241508
T/C (functional) = 190 % Antitumor activity against leukemia P388 in CDF1 mice ChEMBL. 7241508
TI (ADMET) = 16 Therapeutic index was determined against leukemia P388 cells in mice ChEMBL. 7241508
Toxic dose (functional) = 50 mg kg-1 Toxic dose against leukemia P388 in CDF1 mice ChEMBL. 7241508

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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