Detailed information for compound 256706

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 273.169 | Formula: C11H17BrN2O
  • H donors: 1 H acceptors: 1 LogP: 1.98 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1cccc(c1)[N+](C)(C)C.[Br-]
  • InChi: 1S/C11H16N2O.BrH/c1-9(14)12-10-6-5-7-11(8-10)13(2,3)4;/h5-8H,1-4H3;1H
  • InChiKey: DOELWXGKLARSKV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus intermediate filament protein 0.0029 0.0116 0.022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0314 0.0314
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0005 0.0009
Brugia malayi Pre-SET motif family protein 0.0438 0.2525 0.4805
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.008 0.0152
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0017 0.0998
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0457 0.2639 0.5022
Echinococcus multilocularis bloom syndrome protein 0.0023 0.008 0.0152
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.0001 0.0001
Schistosoma mansoni protein phosphatase 2C 0.001 0.0001 0.0001
Echinococcus multilocularis Ankyrin 0.0016 0.0036 0.0069
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0116 0.022
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0068
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0036 0.0068
Schistosoma mansoni intermediate filament proteins 0.0029 0.0116 0.0116
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0314 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.022
Echinococcus granulosus lamin 0.0029 0.0116 0.022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0005 0.0009
Brugia malayi jmjC domain containing protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0161 0.0306
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.001 0.0001 0.0001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0438 0.2525 0.4805
Schistosoma mansoni hypothetical protein 0.003 0.012 0.012
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0519 0.0988
Onchocerca volvulus Alhambra homolog 0.003 0.012 0.0399
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0314 0.0314
Onchocerca volvulus 0.0029 0.0116 0.0386
Trichomonas vaginalis esterase, putative 0.0037 0.0161 0.0503
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0015 0.0028
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.0001 0.0001
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0444 0.256 0.4871
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0017 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0161 0.0306
Loa Loa (eye worm) hypothetical protein 0.0037 0.0161 0.0306
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.012 0.3805
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0045
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.0413 0.0787
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0001 0.004
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0161 0.5111
Brugia malayi intermediate filament protein 0.0029 0.0116 0.022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0005 0.0005
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0017 0.0998
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.001 0.0001 0.0001
Echinococcus granulosus jumonji domain containing 1A 0.001 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0161 1
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.012 0.3805
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0045 0.2765
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0045 0.0085
Mycobacterium leprae Probable lipase LipE 0.0037 0.0161 0.5
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0005 0.0009
Brugia malayi Protein kinase domain containing protein 0.0016 0.0036 0.0068
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0036 0.0068
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.001 0.0001 0.0104
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.012 0.012
Plasmodium vivax hypothetical protein, conserved 0.003 0.012 0.3794
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0005 0.0005
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0188 0.0358
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.0001 0.0001
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0005 0.0009
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0036 0.0068
Brugia malayi jmjC domain containing protein 0.001 0.0001 0.0001
Brugia malayi beta-lactamase 0.0037 0.0161 0.0306
Schistosoma mansoni nuclear hormone receptor 0.001 0.0005 0.0005
Brugia malayi Uncoordinated protein 44 0.0016 0.0036 0.0068
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0051 0.0051
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.008 0.0221
Toxoplasma gondii histone lysine demethylase JMJD6a 0.001 0.0001 0.0017
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0161 0.0306
Onchocerca volvulus 0.0172 0.0961 0.3322
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0188 0.0358
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0161 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0001 0.0045
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0005 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0005 0.0009
Schistosoma mansoni thyroid hormone receptor 0.001 0.0005 0.0005
Loa Loa (eye worm) DOMON domain-containing protein 0.0172 0.0961 0.1828
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0005 0.0009
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0036 0.0036
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0901 0.5255 1
Onchocerca volvulus 0.0029 0.0116 0.0386
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0161 0.0306
Echinococcus multilocularis musashi 0.0029 0.0116 0.022
Brugia malayi jmjC domain containing protein 0.001 0.0001 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0161 1
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Brugia malayi ecdysteroid receptor 0.001 0.0005 0.0009
Echinococcus granulosus bloom syndrome protein 0.0023 0.008 0.0152
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0005 0.0009
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0161 0.0306
Mycobacterium ulcerans lipase LipD 0.0037 0.0161 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0113 0.0214
Schistosoma mansoni netrin receptor unc5 0.0016 0.0036 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0005 0.0009
Schistosoma mansoni lamin 0.0029 0.0116 0.0116
Schistosoma mansoni hypothetical protein 0.0016 0.0036 0.0036
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0116 0.022
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0027 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0005 0.0009
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.001 0.0001 0.0017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0005 0.0009
Echinococcus granulosus FTZ F1 alpha 0.001 0.0005 0.0009
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0116 0.022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0005 0.0009
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.012 0.0227
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0161 0.0503
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0156 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0161 0.0306
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0027 0.0051
Brugia malayi beta-lactamase family protein 0.0037 0.0161 0.0306
Toxoplasma gondii ABC1 family protein 0.0037 0.0161 0.5119
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0063 0.5304
Schistosoma mansoni thyroid hormone receptor 0.001 0.0005 0.0005
Brugia malayi DOMON domain containing protein 0.0172 0.0961 0.1828
Brugia malayi DOMON domain containing protein 0.0172 0.0961 0.1828
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0045 0.0085
Plasmodium falciparum JmjC domain-containing protein, putative 0.001 0.0001 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0005 0.0009
Trichomonas vaginalis set domain proteins, putative 0.0498 0.2882 1
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.0001 0.0001
Echinococcus multilocularis peregrin 0.003 0.012 0.0227
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0161 0.0161
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0005 0.0005
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0036 0.0068
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0036 0.1126
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Brugia malayi DOMON domain containing protein 0.0172 0.0961 0.1828
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0005 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0005 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0005 0.0009
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0161 0.5
Giardia lamblia PHD finger protein 15 0.003 0.012 1
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.012 0.0227
Echinococcus multilocularis lamin dm0 0.0029 0.0116 0.022
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Onchocerca volvulus 0.0037 0.0161 0.0542
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0161 1
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0001 0.004
Onchocerca volvulus 0.0037 0.0161 0.0542
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0519 0.0988
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0036 0.0068
Leishmania major cytochrome p450-like protein 0.0017 0.0045 0.2765
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Brugia malayi PHD-finger family protein 0.001 0.0001 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0005 0.0009
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0036 0.0068
Onchocerca volvulus 0.0037 0.0161 0.0542
Loa Loa (eye worm) RecQ helicase 0.0023 0.008 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0005 0.0009
Brugia malayi beta-lactamase family protein 0.0037 0.0161 0.0306
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0156 0.0156
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0005 0.0009
Loa Loa (eye worm) PHD-finger family protein 0.003 0.012 0.0227
Echinococcus granulosus Ankyrin 0.0016 0.0036 0.0069
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0001 0.0001
Schistosoma mansoni coup transcription factor 0.001 0.0005 0.0005
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0045 0.0085
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.1421 0.2704
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0314 0.0314
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0156 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0005 0.0009
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0005 0.0009
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0045 0.2765
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0161 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.008 0.0221
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0063 0.0314 0.0598
Loa Loa (eye worm) hypothetical protein 0.0037 0.0161 0.0306
Echinococcus granulosus peregrin 0.003 0.012 0.0227
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0156 0.0156
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0036 0.0107
Brugia malayi jmjC domain containing protein 0.001 0.0001 0.0001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0161 0.0161
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0005 0.0009
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0005 0.0009
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.133 1
Echinococcus multilocularis phd:f box containing protein 0.001 0.0001 0.0001
Brugia malayi steroid hormone receptor 0.001 0.0005 0.0009
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0901 0.5255 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.0161 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0161 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0005 0.0009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0005 0.0005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0314 0.0598
Brugia malayi Cytochrome P450 family protein 0.0017 0.0045 0.0085
Schistosoma mansoni jumonji domain containing protein 0.001 0.0001 0.0001
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.012 0.0227
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0005 0.0009
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0045 0.2765
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0901 0.5255 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0161 0.0503
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0161 0.0503
Loa Loa (eye worm) hypothetical protein 0.0037 0.0161 0.0306
Schistosoma mansoni lamin 0.0029 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0045
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0051 0.0245 0.0466
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0036 0.0068
Plasmodium vivax hypothetical protein, conserved 0.001 0.0001 0.0023
Onchocerca volvulus 0.0172 0.0961 0.3322
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0161 0.0503
Brugia malayi Pre-SET motif family protein 0.0063 0.0314 0.0598
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0161 0.0306
Brugia malayi Cytochrome P450 family protein 0.0017 0.0045 0.0085
Schistosoma mansoni phosphatidylserine receptor 0.001 0.0001 0.0001
Onchocerca volvulus 0.0063 0.0314 0.1075
Loa Loa (eye worm) DOMON domain-containing protein 0.0172 0.0961 0.1828
Loa Loa (eye worm) beta-lactamase 0.0037 0.0161 0.0306
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0005 0.0009
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.0413 0.0787
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0017 0.0998
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0005 0.0009
Plasmodium falciparum phd finger protein, putative 0.003 0.012 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0005 0.0009
Echinococcus granulosus phd:f box containing protein 0.001 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0005 0.0009
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0314 0.0598
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Brugia malayi PHD-finger family protein 0.003 0.012 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0005 0.0009
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0005 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0005 0.0009
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0901 0.5255 1
Loa Loa (eye worm) hypothetical protein 0.0901 0.5255 1
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0901 0.5255 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0161 0.0503
Schistosoma mansoni phd/f-box containing protein 0.001 0.0001 0.0001
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0036 0.0068
Brugia malayi follicle stimulating hormone receptor 0.025 0.1421 0.2704
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.01
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Brugia malayi Bromodomain containing protein 0.003 0.012 0.0227
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0005 0.0009
Onchocerca volvulus 0.0498 0.2883 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0005 0.0009
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.03 0.0572
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0314 0.0598
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0901 0.5255 0.5255
Brugia malayi jmjC domain containing protein 0.0036 0.0156 0.0298
Schistosoma mansoni peptidylglycine monooxygenase 0.0901 0.5255 0.5255
Loa Loa (eye worm) DOMON domain-containing protein 0.0172 0.0961 0.1828
Plasmodium vivax SET domain protein, putative 0.0063 0.0314 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0307 0.0583
Brugia malayi Death domain containing protein 0.0016 0.0036 0.0068
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0401 0.0401
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0037 0.0161 1
Echinococcus granulosus death domain containing protein 0.0016 0.0036 0.0068
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0156 0.0298
Brugia malayi nuclear hormone receptor 0.001 0.0005 0.0009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0035 0.1106
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0005 0.0009
Brugia malayi jmjC domain containing protein 0.0098 0.0519 0.0988
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0001 0.0045
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0001 0.0001
Brugia malayi AF-10 protein 0.001 0.0001 0.0002
Echinococcus multilocularis lamin 0.0029 0.0116 0.022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0015 0.0015
Echinococcus granulosus lamin dm0 0.0029 0.0116 0.022
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.001 0.0001 0.0001
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0005 0.0005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0005 0.0005

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.001 M Inhibitory activity against Acetylcholinesterase ChEMBL. 8978837
IC50 (binding) = 1 nM Inhibitory activity against Acetylcholinesterase ChEMBL. 8978837

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.