Detailed information for compound 256942

Basic information

Technical information
  • TDR Targets ID: 256942
  • Name: (4R)-2-[2-(2-hydroxyphenyl)ethyl]-1,3-thiazol idine-4-carboxylic acid
  • MW: 253.317 | Formula: C12H15NO3S
  • H donors: 3 H acceptors: 3 LogP: -0.31 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@@H]1CSC(N1)CCc1ccccc1O
  • InChi: 1S/C12H15NO3S/c14-10-4-2-1-3-8(10)5-6-11-13-9(7-17-11)12(15)16/h1-4,9,11,13-14H,5-7H2,(H,15,16)/t9-,11?/m0/s1
  • InChiKey: ARLUWJUHWBBIOJ-FTNKSUMCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4R)-2-[2-(2-hydroxyphenyl)ethyl]thiazolidine-4-carboxylic acid
  • (4R)-2-[2-(2-hydroxyphenyl)ethyl]-4-thiazolidinecarboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0153 0.0504
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0963 0.5256 1
Schistosoma mansoni phd/f-box containing protein 0.001 0.0001 0.0001
Schistosoma mansoni peptidylglycine monooxygenase 0.0963 0.5256 0.5256
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0963 0.5256 0.5256
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0005 0.0009
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0005 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0005 0.0009
Onchocerca volvulus 0.0506 0.2736 1
Echinococcus granulosus peregrin 0.003 0.0113 0.0216
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0095
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0033 0.1106
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.1348 0.2565
Mycobacterium leprae Probable lipase LipE 0.0037 0.0153 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0298 0.0298
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0285 0.0543
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0963 0.5256 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0005 0.0009
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0381 0.0381
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0034 0.0034
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0291 0.0554
Brugia malayi DOMON domain containing protein 0.0184 0.0963 0.1833
Brugia malayi Pre-SET motif family protein 0.0064 0.0298 0.0567
Loa Loa (eye worm) hypothetical protein 0.0963 0.5256 1
Brugia malayi beta-lactamase 0.0037 0.0153 0.029
Brugia malayi Uncoordinated protein 44 0.0016 0.0034 0.0064
Brugia malayi beta-lactamase family protein 0.0037 0.0153 0.029
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0001 0.0001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0493 0.0938
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0005 0.0009
Brugia malayi nuclear hormone receptor 0.001 0.0005 0.0009
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0034 0.1125
Brugia malayi AF-10 protein 0.001 0.0001 0.0002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0005 0.0009
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0001 0.0045
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0005 0.0005
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0005 0.0005
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0107 0.0203
Schistosoma mansoni lamin 0.003 0.011 0.011
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0016 0.0996
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0963 0.5256 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0005 0.0009
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0043 0.2762
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0005 0.0009
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.011 0.0209
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0153 0.5112
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0153 0.029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0149 0.0149
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0153 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0034 0.0064
Onchocerca volvulus 0.0184 0.0963 0.351
Plasmodium vivax hypothetical protein, conserved 0.001 0.0001 0.0023
Loa Loa (eye worm) hypothetical protein 0.0052 0.0233 0.0443
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0025 0.0048
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0005 0.0005
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.029
Schistosoma mansoni phosphatidylserine receptor 0.001 0.0001 0.0001
Loa Loa (eye worm) DOMON domain-containing protein 0.0184 0.0963 0.1833
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0298 0.0567
Leishmania major cytochrome p450-like protein 0.0017 0.0043 0.2762
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0153 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0298 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0005 0.0009
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0392 0.0746
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0016 0.0996
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0005 0.0009
Echinococcus granulosus phd:f box containing protein 0.001 0.0001 0.0001
Echinococcus granulosus intermediate filament protein 0.003 0.011 0.0209
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0298 1
Brugia malayi Protein kinase domain containing protein 0.0016 0.0034 0.0064
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0043 0.0081
Brugia malayi follicle stimulating hormone receptor 0.0254 0.1348 0.2565
Schistosoma mansoni coup transcription factor 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0153 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0298 0.0298
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0076 0.0221
Mycobacterium ulcerans hypothetical protein 0.0037 0.0153 1
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0043 0.2762
Echinococcus multilocularis phd:f box containing protein 0.001 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0005 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0298 0.0298
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0005 0.0005
Echinococcus granulosus death domain containing protein 0.0016 0.0034 0.0064
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0153 1
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0113 0.0216
Loa Loa (eye worm) hypothetical protein 0.0963 0.5256 1
Brugia malayi steroid hormone receptor 0.001 0.0005 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0001 0.0001
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.1263 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0005 0.0009
Onchocerca volvulus 0.0037 0.0153 0.0542
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Brugia malayi jmjC domain containing protein 0.001 0.0001 0.0001
Onchocerca volvulus 0.003 0.011 0.0386
Schistosoma mansoni jumonji domain containing protein 0.001 0.0001 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0043 0.0081
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0005 0.0005
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0298 0.0567
Brugia malayi nuclear receptor NHR-88 0.001 0.0005 0.0009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0149 0.0149
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0153 0.029
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0149 0.0283
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0005 0.0009
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0002
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0113 0.3806
Brugia malayi Bromodomain containing protein 0.003 0.0113 0.0216
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0043 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0066
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0153 0.029
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0493 0.0938
Trichomonas vaginalis esterase, putative 0.0037 0.0153 0.0504
Brugia malayi jmjC domain containing protein 0.0037 0.0149 0.0283
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0001 0.004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0005 0.0009
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0034 0.0065
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0005 0.0009
Brugia malayi PHD-finger family protein 0.001 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0016 0.0034 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0005 0.0009
Loa Loa (eye worm) RecQ helicase 0.0023 0.0076 0.0144
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0113 0.0216
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0005 0.0009
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0153 0.029
Brugia malayi beta-lactamase family protein 0.0037 0.0153 0.029
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0005 0.0009
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0025 0.0048
Schistosoma mansoni lamin 0.003 0.011 0.011
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0034 0.0064
Schistosoma mansoni intermediate filament proteins 0.003 0.011 0.011
Echinococcus granulosus FTZ F1 alpha 0.001 0.0005 0.0009
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0005 0.0009
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.001 0.0001 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0153 0.0504
Echinococcus granulosus lamin dm0 0.003 0.011 0.0209
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0005 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0153 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0025 0.0048
Toxoplasma gondii ABC1 family protein 0.0037 0.0153 0.5121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0005 0.0009
Leishmania major hypothetical protein, conserved 0.0037 0.0153 1
Loa Loa (eye worm) DOMON domain-containing protein 0.0184 0.0963 0.1833
Schistosoma mansoni thyroid hormone receptor 0.001 0.0005 0.0005
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.006 0.53
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.029
Trichomonas vaginalis set domain proteins, putative 0.0506 0.2735 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0005 0.0009
Plasmodium falciparum JmjC domain-containing protein, putative 0.001 0.0001 0.0047
Brugia malayi Cytochrome P450 family protein 0.0017 0.0043 0.0081
Brugia malayi DOMON domain containing protein 0.0184 0.0963 0.1833
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0005 0.0009
Brugia malayi DOMON domain containing protein 0.0184 0.0963 0.1833
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0034 0.0034
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0034 0.0064
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.029
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0005 0.0005
Echinococcus multilocularis musashi 0.003 0.011 0.0209
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.0001 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0001 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0005 0.0009
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0076 0.0221
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0049 0.0049
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0005 0.0009
Schistosoma mansoni netrin receptor unc5 0.0016 0.0034 0.0034
Mycobacterium ulcerans lipase LipD 0.0037 0.0153 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.001 0.0001 0.0018
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0005 0.0009
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0001 0.0045
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0149 0.0283
Loa Loa (eye worm) DOMON domain-containing protein 0.0184 0.0963 0.1833
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0179 0.034
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0963 0.5256 1
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0034 0.0064
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0005 0.0009
Onchocerca volvulus 0.0184 0.0963 0.351
Schistosoma mansoni thyroid hormone receptor 0.001 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0005 0.0009
Brugia malayi jmjC domain containing protein 0.001 0.0001 0.0001
Plasmodium vivax hypothetical protein, conserved 0.003 0.0113 0.3795
Onchocerca volvulus 0.0037 0.0153 0.0542
Echinococcus multilocularis lamin dm0 0.003 0.011 0.0209
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0298 0.0567
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0153 0.0504
Echinococcus multilocularis Ankyrin 0.0016 0.0034 0.0066
Echinococcus multilocularis peregrin 0.003 0.0113 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0005 0.0009
Mycobacterium ulcerans beta-lactamase 0.0037 0.0153 1
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0153 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0005 0.0009
Echinococcus granulosus bloom syndrome protein 0.0023 0.0076 0.0144
Brugia malayi ecdysteroid receptor 0.001 0.0005 0.0009
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.0001 0.0001
Plasmodium falciparum phd finger protein, putative 0.003 0.0113 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.029
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0153 0.0504
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0016 0.0996
Loa Loa (eye worm) beta-lactamase 0.0037 0.0153 0.029
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0113 0.3806
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0392 0.0746
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0001 0.004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0043
Giardia lamblia PHD finger protein 15 0.003 0.0113 1
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0016 0.5
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0034 0.0064
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0005 0.0005
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0043 0.2762
Brugia malayi intermediate filament protein 0.003 0.011 0.0209
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0153 0.0153
Echinococcus granulosus jumonji domain containing 1A 0.001 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0153 0.0504
Brugia malayi Cytochrome P450 family protein 0.0017 0.0043 0.0081
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0034 0.0065
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0005 0.0005
Echinococcus granulosus lamin 0.003 0.011 0.0209
Onchocerca volvulus 0.003 0.011 0.0386
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.001 0.0001 0.0106
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0034 0.0107
Schistosoma mansoni nuclear hormone receptor 0.001 0.0005 0.0005
Onchocerca volvulus 0.0037 0.0153 0.0542
Brugia malayi jmjC domain containing protein 0.001 0.0001 0.0001
Echinococcus granulosus Ankyrin 0.0016 0.0034 0.0066
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0005 0.0009
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0179 0.034
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0005 0.0009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0216
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0014 0.0014
Brugia malayi Pre-SET motif family protein 0.0444 0.2397 0.456
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0076 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0064 0.0298 0.0567
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0043
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.001 0.0001 0.0001
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0113 0.0216
Brugia malayi Death domain containing protein 0.0016 0.0034 0.0064
Schistosoma mansoni protein phosphatase 2C 0.001 0.0001 0.0001
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.0001 0.0001
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0489 0.2641 0.5025
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0076 0.0144
Onchocerca volvulus 0.0064 0.0298 0.1075
Loa Loa (eye worm) intermediate filament protein 0.003 0.011 0.0209
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.011 0.0209
Schistosoma mansoni hypothetical protein 0.0016 0.0034 0.0034
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0034 0.0064
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0005 0.0009
Schistosoma mansoni hypothetical protein 0.003 0.0113 0.0113
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.001 0.0001 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0149 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0005 0.0009
Brugia malayi jmjC domain containing protein 0.001 0.0001 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0005 0.0009
Plasmodium vivax SET domain protein, putative 0.0064 0.0298 1
Brugia malayi PHD-finger family protein 0.003 0.0113 0.0216
Onchocerca volvulus Alhambra homolog 0.003 0.0113 0.0399
Brugia malayi jmjC domain containing protein 0.0099 0.0493 0.0938
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0444 0.2397 0.456
Echinococcus multilocularis lamin 0.003 0.011 0.0209
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0474 0.2562 0.4874
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0005 0.0009
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0014 0.0027
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0153 0.029

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 45 mg kg-1 Inhibition of irritant electrically-induced coughing in guinea pig trachea following p.o. administration. ChEMBL. 7853344
Inhibition (functional) < 20 % Antitussive activity was evaluated by inhibition of irritant citric acid aerosol-induced coughing in guinea pig upon oral administration at 30 mg/kg dose ChEMBL. 7853344
LD50 (ADMET) > 1000 mg kg-1 Acute toxicity was determined in mice upon peroral administration ChEMBL. 7853344
LD50 (ADMET) > 1000 mg kg-1 Acute toxicity was determined in mice upon peroral administration ChEMBL. 7853344

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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