Detailed information for compound 26036

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 195.324 | Formula: C11H17NS
  • H donors: 0 H acceptors: 0 LogP: 2.87 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C1N(C)CCc2c1scc2)C
  • InChi: 1S/C11H17NS/c1-8(2)10-11-9(5-7-13-11)4-6-12(10)3/h5,7-8,10H,4,6H2,1-3H3
  • InChiKey: QKQIZBXKGOBGFZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Glutamate [NMDA] receptor subunit epsilon 3 Starlite/ChEMBL References
Rattus norvegicus Sigma opioid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Echinococcus granulosus glutamate NMDA receptor subunit Get druggable targets OG5_129290 All targets in OG5_129290
Echinococcus multilocularis glutamate (NMDA) receptor subunit Get druggable targets OG5_129290 All targets in OG5_129290
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma mansoni glutamate receptor NMDA Get druggable targets OG5_129290 All targets in OG5_129290
Schistosoma japonicum ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative Get druggable targets OG5_129290 All targets in OG5_129290
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0029 0.0028 0.0155
Brugia malayi glutathione reductase 0.0047 0.0083 0.0424
Leishmania major trypanothione reductase 0.0047 0.0083 0.0574
Leishmania major ATP-dependent phosphofructokinase 0.022 0.0622 0.4684
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0056 0.0043
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0257 0.0737 0.3756
Echinococcus granulosus voltage dependent calcium channel subunit 0.1472 0.4514 0.4506
Trichomonas vaginalis 6-phosphofructokinase, putative 0.006 0.0122 0.0523
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0083 0.3332
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0056 0.0369
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0024 0.0011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0067 0.0053
Brugia malayi hypothetical protein 0.006 0.0124 0.0633
Mycobacterium ulcerans 6-phosphofructokinase 0.022 0.0622 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0083 0.1337
Brugia malayi hypothetical protein 0.0245 0.0698 0.3556
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0028 0.0155
Onchocerca volvulus 0.005 0.0093 0.0421
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.027 0.4338
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0083 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0024 0.0125
Entamoeba histolytica hypothetical protein, conserved 0.006 0.0124 0.1893
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0122 0.0523
Schistosoma mansoni ap endonuclease 0.004 0.0061 0.0109
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0056 0.0043
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.006 0.0122 0.0104
Brugia malayi Protein kinase domain containing protein 0.0025 0.0014 0.007
Schistosoma mansoni slit 0.0025 0.0014 0.0001
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.027 0.4338
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0024 0.0025
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0024 0.0111
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0319
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0125
Echinococcus granulosus neurogenic locus notch protein 0.0025 0.0014 0.0001
Echinococcus granulosus slit 2 protein 0.0025 0.0014 0.0001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0201 0.0562 0.9031
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.006 0.0122 0.1863
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0104 0.0259 0.0569
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0032 0.0036 0.0183
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0028 0.0155
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0025 0.0014 0.0001
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0029 0.0027 0.0623
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0061 0.2252
Entamoeba histolytica phosphofructokinase, putative 0.022 0.0622 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0061 0.0648
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0024 0.0011
Echinococcus granulosus leukotriene A 4 hydrolase 0.0257 0.0737 0.0725
Brugia malayi Cache domain containing protein 0.0652 0.1963 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0024 0.0011
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0122 0.0523
Toxoplasma gondii aldehyde dehydrogenase 0.0201 0.0562 1
Brugia malayi intermediate filament protein 0.0087 0.0207 0.1055
Mycobacterium tuberculosis Probable reductase 0.0107 0.027 0.4338
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0212 0.0198
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0142 0.1025
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.027 0.4338
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0639 0.1923 0.9794
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0124 0.0633
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0134 0.0962
Plasmodium falciparum thioredoxin reductase 0.0047 0.0083 0.4295
Echinococcus granulosus collagen alpha 1VII chain 0.006 0.0124 0.0111
Entamoeba histolytica hypothetical protein, conserved 0.006 0.0124 0.1893
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0056 0.0221
Entamoeba histolytica hypothetical protein 0.0042 0.0067 0.0962
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0024 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0024 0.0125
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0024 0.0125
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.027 0.4338
Brugia malayi Zona pellucida-like domain containing protein 0.006 0.0124 0.0633
Schistosoma mansoni ap endonuclease 0.004 0.0061 0.0109
Schistosoma mansoni hypothetical protein 0.076 0.2301 0.5303
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0056 0.0099
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1942 0.5974 1
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.0622 0.2806
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0033 0.0041 0.0027
Echinococcus multilocularis collagen alpha 1(VII) chain 0.006 0.0124 0.0111
Schistosoma mansoni coup transcription factor 0.0028 0.0024 0.0025
Loa Loa (eye worm) hypothetical protein 0.006 0.0124 0.0633
Schistosoma mansoni aldehyde dehydrogenase 0.0201 0.0562 0.1271
Schistosoma mansoni aldehyde dehydrogenase 0.0201 0.0562 0.1271
Toxoplasma gondii thioredoxin reductase 0.0047 0.0083 0.1267
Echinococcus multilocularis bloom syndrome protein 0.0042 0.0069 0.0056
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.006 0.0124 0.5303
Echinococcus granulosus glutamate receptor 2 0.0033 0.0041 0.0027
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0056 0.0042
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.022 0.0622 0.4684
Leishmania major cathepsin L-like protease 0.0063 0.0134 0.0962
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0061 0.2902
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0069 0.0281
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.0222 0.0209
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0024 0.0025
Onchocerca volvulus 0.0087 0.0207 0.0943
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0083 0.0195 0.0182
Loa Loa (eye worm) hypothetical protein 0.0092 0.0222 0.1132
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0117 0.0832
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.0622 0.2806
Mycobacterium ulcerans endonuclease IV 0.0077 0.0175 0.282
Brugia malayi follicle stimulating hormone receptor 0.0474 0.1412 0.719
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0024 0.0125
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0067 0.0124
Onchocerca volvulus 0.006 0.0124 0.0565
Schistosoma mansoni 6-phosphofructokinase 0.022 0.0622 0.1411
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.022 0.0622 1
Schistosoma mansoni lozenge 0.0055 0.0109 0.022
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0041 0.0027
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.0222 0.3803
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.132 1
Echinococcus granulosus lamin 0.0087 0.0207 0.0194
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.027 0.4338
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0068 0.0054
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0142 0.2189
Entamoeba histolytica hypothetical protein 0.006 0.0124 0.1893
Toxoplasma gondii phosphofructokinase PFKII 0.006 0.0122 0.1983
Plasmodium vivax hypothetical protein, conserved 0.006 0.0124 0.5303
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0061 0.0309
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.006 0.0124 0.5303
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0024 0.0125
Loa Loa (eye worm) hypothetical protein 0.006 0.0124 0.0633
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0122 0.0523
Loa Loa (eye worm) hypothetical protein 0.0445 0.132 0.6721
Echinococcus multilocularis 6 phosphofructokinase 0.022 0.0622 0.0609
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0073
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0134 0.0962
Schistosoma mansoni glutamate receptor NMDA 0.0033 0.0041 0.0063
Entamoeba histolytica phosphofructokinase, putative 0.022 0.0622 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0201 0.0562 0.9031
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0077 0.0175 0.282
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0073
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0124 0.0633
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0201 0.0562 0.0549
Loa Loa (eye worm) hypothetical protein 0.006 0.0124 0.0633
Schistosoma mansoni lamin 0.0087 0.0207 0.0448
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0124 0.0633
Schistosoma mansoni cell polarity protein 0.0025 0.0014 0.0001
Loa Loa (eye worm) TK/ROR protein kinase 0.0025 0.0014 0.007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0125
Schistosoma mansoni hypothetical protein 0.006 0.0124 0.0256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0134 0.0962
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.006 0.0124 0.0633
Onchocerca volvulus 0.0025 0.0014 0.0062
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0041 0.0027
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0082 0.0194 0.0987
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0032 0.0036 0.0183
Brugia malayi Receptor family ligand binding region containing protein 0.0032 0.0036 0.0183
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0028 0.0897
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0222 0.0483
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.132 1
Echinococcus multilocularis slit 2 protein 0.0025 0.0014 0.0001
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.0698 0.0685
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0061 0.0858
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0024 0.0125
Onchocerca volvulus 0.006 0.0124 0.0565
Loa Loa (eye worm) hypothetical protein 0.006 0.0124 0.0633
Schistosoma mansoni lamin 0.0087 0.0207 0.0448
Loa Loa (eye worm) hypothetical protein 0.006 0.0124 0.0633
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0082 0.0417
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0061 0.0047
Treponema pallidum 76K protein 0.006 0.0124 0.0108
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.022 0.0622 0.4684
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.006 0.0124 0.0633
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.0069 0.0354
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0024 0.0125
Schistosoma mansoni hypothetical protein 0.0146 0.0391 0.0875
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0134 0.0962
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0024 0.0011
Loa Loa (eye worm) CUTiclin family member 0.006 0.0124 0.0633
Brugia malayi nuclear hormone receptor 0.0028 0.0024 0.0125
Loa Loa (eye worm) CUTiclin-Like family member 0.006 0.0124 0.0633
Loa Loa (eye worm) glutamate receptor 0.0099 0.0246 0.1255
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0024 0.0125
Trichomonas vaginalis set domain proteins, putative 0.0727 0.2197 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.132 0.6721
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0307 0.4935
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.027 0.4338
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0028 0.0155
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0077 0.0175 0.282
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.006 0.0124 0.5303
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.006 0.0124 0.6834
Brugia malayi hypothetical protein 0.0029 0.0028 0.0144
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0124 0.0633
Loa Loa (eye worm) cytochrome P450 family protein 0.0072 0.0161 0.0822
Onchocerca volvulus 0.006 0.0124 0.0565
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0061 0.0241
Echinococcus granulosus intermediate filament protein 0.0087 0.0207 0.0194
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0083 0.0424
Brugia malayi Zona pellucida-like domain containing protein 0.006 0.0124 0.0633
Onchocerca volvulus 0.0057 0.0116 0.0526
Loa Loa (eye worm) hypothetical protein 0.0439 0.1303 0.6637
Echinococcus granulosus glutamate NMDA receptor subunit 0.0083 0.0195 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0092 0.0222 0.0483
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0024 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.0622 0.2806
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0041 0.0027
Treponema pallidum hypothetical protein 0.006 0.0124 0.0108
Loa Loa (eye worm) hypothetical protein 0.006 0.0124 0.0633
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0134 0.0962
Echinococcus multilocularis voltage dependent calcium channel subunit 0.3237 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.022 0.0622 0.2806
Onchocerca volvulus 0.0028 0.0024 0.0111
Echinococcus multilocularis lamin 0.0087 0.0207 0.0194
Plasmodium falciparum von Willebrand factor A domain-related protein 0.006 0.0124 0.6834
Loa Loa (eye worm) hypothetical protein 0.006 0.0124 0.0633
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0024 0.0011
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0024 0.0125
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0085 0.02 0.0187
Brugia malayi EGF-like domain containing protein 0.0025 0.0014 0.0073
Schistosoma mansoni thyroid hormone receptor 0.0174 0.0478 0.1077
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0061 0.0402
Toxoplasma gondii endonuclease IV APN 0.0077 0.0175 0.2951
Echinococcus multilocularis expressed protein 0.0386 0.1138 0.1126
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0042 0.0068 0.1085
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0056 0.0369
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0122 0.0523
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0307 0.4935
Echinococcus granulosus 6 phosphofructokinase 0.022 0.0622 0.0609
Onchocerca volvulus 0.0727 0.2197 1
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0092 0.0641
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0024 0.0125
Brugia malayi metabotropic glutamate receptor type 2 0.0053 0.0101 0.0516
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.006 0.0124 0.0633
Toxoplasma gondii phosphofructokinase domain-containing protein 0.006 0.0122 0.1983
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0061 0.0402
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0083 0.0574
Loa Loa (eye worm) hypothetical protein 0.006 0.0124 0.0633
Loa Loa (eye worm) glutathione reductase 0.0047 0.0083 0.0424
Plasmodium vivax SET domain protein, putative 0.0092 0.0222 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0202 0.103
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0125
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0056 0.0221
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0122 0.5083
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0067 0.0053
Brugia malayi Pre-SET motif family protein 0.0639 0.1923 0.9794
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0077 0.0175 0.0894
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0024 0.0011
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.006 0.0122 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0063 0.0319
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0122 0.6719
Brugia malayi laminin alpha chain 0.0025 0.0014 0.0073
Onchocerca volvulus 0.006 0.0124 0.0565
Echinococcus multilocularis Protein lozenge 0.0055 0.0109 0.0095
Brugia malayi Intermediate filament tail domain containing protein 0.0087 0.0207 0.1055
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0026 0.0218
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0058 0.0118 0.0105
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0056 0.0287
Loa Loa (eye worm) hypothetical protein 0.006 0.0124 0.0633
Brugia malayi hypothetical protein 0.0126 0.0329 0.1676
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0056 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0024 0.0125
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.1412 0.4327 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0257 0.0737 0.1678
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0024 0.0125
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0036 0.0183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0134 0.0962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0134 0.0962
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0122 0.5214
Brugia malayi Kringle domain containing protein 0.0025 0.0014 0.007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0024 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0024 0.0125
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0142 0.1025
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0028 0.0897
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0082 0.0417
Leishmania major cathepsin L-like protease 0.0063 0.0134 0.0962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0134 0.0962
Echinococcus granulosus expressed protein 0.0386 0.1138 0.1126
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0125
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0041 0.0027
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0061 0.0402
Brugia malayi Metabotropic glutamate receptor precursor. 0.0099 0.0246 0.1255
Onchocerca volvulus 0.006 0.0124 0.0565
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0056 0.0369
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0134 0.0962
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0024 0.0025
Echinococcus multilocularis lamin dm0 0.0087 0.0207 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0024 0.0125
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0024 0.0025
Chlamydia trachomatis endonuclease IV 0.0077 0.0175 1
Schistosoma mansoni 6-phosphofructokinase 0.022 0.0622 0.1411
Onchocerca volvulus 0.0092 0.0222 0.1011
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.022 0.0622 0.095
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0024 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0024 0.0125
Leishmania major cathepsin L-like protease 0.0063 0.0134 0.0962
Loa Loa (eye worm) hypothetical protein 0.0034 0.0043 0.0218
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0061 0.0309
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0024 0.0111
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0134 0.0962
Brugia malayi von Willebrand Factor 0.006 0.0124 0.0633
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0307 0.4935
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0142 0.0725
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0042 0.0068 0.0012
Brugia malayi phosphofructokinase 0.022 0.0622 0.3169
Echinococcus multilocularis pikachurin 0.0025 0.0014 0.0001
Loa Loa (eye worm) intermediate filament protein 0.0087 0.0207 0.1055
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0061 0.0402
Plasmodium vivax thrombospondin-related anonymous protein 0.006 0.0124 0.5303
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0041 0.0027
Onchocerca volvulus 0.006 0.0124 0.0565
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0061 0.0975
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0024 0.0011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0087 0.0207 0.1055
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.0069 0.0281
Brugia malayi hypothetical protein 0.0042 0.0067 0.0341
Toxoplasma gondii 6-phosphofructokinase 0.006 0.0122 0.1983
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0068 0.0054
Echinococcus granulosus pikachurin 0.0025 0.0014 0.0001
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0307 0.4935
Loa Loa (eye worm) 6-phosphofructokinase 0.022 0.0622 0.3169
Loa Loa (eye worm) hypothetical protein 0.012 0.0312 0.1588
Echinococcus granulosus metabotropic glutamate receptor 5 0.012 0.0312 0.0299
Brugia malayi hypothetical protein 0.0439 0.1303 0.6637
Echinococcus multilocularis musashi 0.0087 0.0207 0.0194
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0042 0.0068 0.0012
Schistosoma mansoni intermediate filament proteins 0.0087 0.0207 0.0448
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0124 0.0633
Loa Loa (eye worm) hypothetical protein 0.0245 0.0698 0.3556
Echinococcus granulosus histone lysine methyltransferase setb 0.0092 0.0222 0.0209
Echinococcus multilocularis thyroid hormone receptor alpha 0.0174 0.0478 0.0465
Schistosoma mansoni thyroid hormone receptor 0.0174 0.0478 0.1077
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0056 0.0221
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0146 0.0391 0.0378
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0056 0.0043
Loa Loa (eye worm) hypothetical protein 0.0652 0.1963 1
Loa Loa (eye worm) 6-phosphofructokinase 0.022 0.0622 0.3169
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.0698 0.0685
Schistosoma mansoni survival motor neuron protein 0.005 0.0093 0.0183
Brugia malayi ecdysteroid receptor 0.0028 0.0024 0.0125
Onchocerca volvulus 0.0087 0.0207 0.0943
Plasmodium vivax glutathione reductase, putative 0.0047 0.0083 0.3332
Schistosoma mansoni laminin gamma-3 chain 0.0025 0.0014 0.0001
Onchocerca volvulus 0.006 0.0124 0.0565
Brugia malayi laminin-like protein K08C7.3 precursor 0.0025 0.0014 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0222 0.0483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0134 0.0962
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.006 0.0124 0.0633
Toxoplasma gondii exonuclease III APE 0.004 0.0061 0.0856
Loa Loa (eye worm) runx1 0.0055 0.0109 0.0554
Plasmodium falciparum thrombospondin-related anonymous protein 0.006 0.0124 0.6834
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0024 0.0125
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0025 0.0014 0.0073
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0125
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0056 0.0099
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0122 0.6719
Echinococcus multilocularis metabotropic glutamate receptor 5 0.012 0.0312 0.0299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0134 0.0962
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0024 0.0011
Schistosoma mansoni metabotropic glutamate receptor 0.0085 0.02 0.0433
Entamoeba histolytica hypothetical protein 0.0042 0.0067 0.0962
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0024 0.0025
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0061 0.5
Echinococcus granulosus lamin dm0 0.0087 0.0207 0.0194
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0116 0.0236
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0033 0.0041 0.0027
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.006 0.0124 0.2017
Toxoplasma gondii microneme protein MIC2 0.006 0.0124 0.2017
Loa Loa (eye worm) hypothetical protein 0.0042 0.0068 0.0344
Entamoeba histolytica hypothetical protein 0.0042 0.0067 0.0962
Loa Loa (eye worm) hypothetical protein 0.006 0.0124 0.0633
Loa Loa (eye worm) hypothetical protein 0.006 0.0124 0.0633
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0134 0.0962
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0024 0.0125
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0201 0.0562 0.4224
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0125
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0024 0.0025
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0142 0.0725
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0175 0.776
Schistosoma mansoni hypothetical protein 0.005 0.0093 0.0183
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0124 0.0633
Echinococcus multilocularis tumor protein p63 0.0392 0.1155 0.1143
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0201 0.0562 0.0549
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0083 0.007
Echinococcus granulosus tumor protein p63 0.0392 0.1155 0.1143
Trypanosoma brucei trypanothione reductase 0.0047 0.0083 0.0574
Entamoeba histolytica elongation factor-2 kinase, putative 0.006 0.0124 0.1893
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0124 0.0633
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0142 0.1025
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0474 0.1412 0.719
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0146 0.0391 0.0378
Brugia malayi hypothetical protein 0.0118 0.0305 0.1555
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0142 0.0129
Loa Loa (eye worm) abnormal epIthelia family member 0.0025 0.0014 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0024 0.0125
Brugia malayi nuclear receptor NHR-88 0.0028 0.0024 0.0125
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0122 0.0523
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0134 0.0962
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0093 0.0471
Loa Loa (eye worm) hypothetical protein 0.006 0.0124 0.0633
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.006 0.0122 0.5083
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0201 0.0562 0.9031
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0061 0.0241
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0033 0.0041 0.0027
Brugia malayi Cytochrome P450 family protein 0.0072 0.0161 0.0822
Loa Loa (eye worm) hypothetical protein 0.0057 0.0116 0.0589
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0122 0.5214
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0025 0.0014 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0024 0.0125
Leishmania major hypothetical protein, conserved 0.0025 0.0014 0.0044
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0175 1
Loa Loa (eye worm) hypothetical protein 0.0328 0.0958 0.4879
Brugia malayi steroid hormone receptor 0.0028 0.0024 0.0125
Echinococcus granulosus nmda type glutamate receptor 0.0058 0.0118 0.0105
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0061 0.0047
Entamoeba histolytica phosphofructokinase, putative 0.022 0.0622 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0033 0.0041 0.0027
Brugia malayi 6-phosphofructokinase 0.022 0.0622 0.3169
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0142 0.1025
Schistosoma mansoni metabotropic glutamate receptor 0.0053 0.0101 0.0203
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.022 0.0622 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0087 0.0207 0.1055
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0061 0.0975
Schistosoma mansoni blooms syndrome DNA helicase 0.0034 0.0042 0.0065
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0024 0.0125
Brugia malayi 6-phosphofructokinase 0.022 0.0622 0.3169
Brugia malayi Thioredoxin reductase 0.0047 0.0083 0.0424
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0142 0.0129
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0024 0.0025
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0257 0.0737 0.0725
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0024 0.0011
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0024 0.0025
Echinococcus granulosus bloom syndrome protein 0.0042 0.0069 0.0056
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0056 0.0369
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0124 0.0633
Schistosoma mansoni serine-rich repeat protein 0.076 0.2301 0.5303
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0028 0.0265
Echinococcus multilocularis neurogenic locus notch protein 0.0025 0.0014 0.0001
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1472 0.4514 0.4506
Schistosoma mansoni hypothetical protein 0.006 0.0124 0.0256
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0024 0.0125
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0024 0.0011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0125
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0712 0.215 0.4953
Schistosoma mansoni glutamate receptor NMDA 0.0083 0.0195 0.0421
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0056 0.0788
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0056 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0024 0.0125
Echinococcus granulosus metabotropic glutamate receptor 2 0.0085 0.02 0.0187
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0042 0.0068 0.1085
Loa Loa (eye worm) hypothetical protein 0.0038 0.0056 0.0287
Loa Loa (eye worm) hypothetical protein 0.0227 0.0644 0.3279
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0024 0.0125
Schistosoma mansoni hypothetical protein 0.0042 0.0067 0.0124
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0037 0.0053 0.2456
Echinococcus multilocularis nmda type glutamate receptor 0.0058 0.0118 0.0105
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0056 0.0043
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0142 0.0298
Loa Loa (eye worm) hypothetical protein 0.006 0.0124 0.0633
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0056 0.0042
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0024 0.0111
Entamoeba histolytica hypothetical protein 0.0042 0.0067 0.0962
Brugia malayi Pre-SET motif family protein 0.0092 0.0222 0.1132
Loa Loa (eye worm) hypothetical protein 0.0439 0.1303 0.6637
Plasmodium falciparum glutathione reductase 0.0047 0.0083 0.4295
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0092 0.0222 0.0209
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.006 0.0124 0.0531
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0024 0.0125
Mycobacterium ulcerans aldehyde dehydrogenase 0.0201 0.0562 0.9031
Loa Loa (eye worm) hypothetical protein 0.0077 0.0175 0.0894
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0134 0.0962
Onchocerca volvulus 0.0439 0.1303 0.593
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0014 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0122 0.0523
Loa Loa (eye worm) phosphofructokinase 0.022 0.0622 0.3169
Loa Loa (eye worm) glutamate receptor 0.0036 0.0049 0.0248
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0028 0.0696
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0124 0.0633
Loa Loa (eye worm) RecQ helicase 0.0042 0.0069 0.0354
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.132 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0222 0.0483

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.8 uM Inhibition of [3H]- N-allylnormetazocine ([3H]-NANM) binding to sigma receptor ChEMBL. 2542555
IC50 (binding) = 7.8 uM Inhibition of [3H]- N-allylnormetazocine ([3H]-NANM) binding to sigma receptor ChEMBL. 2542555
IC50 (binding) = 17 uM Inhibition of [3H]-1-[1-(2-thienyl) piperidine ([3H]-TCP) binding to PCP receptor ChEMBL. 2542555
IC50 (binding) = 17 uM Inhibition of [3H]-1-[1-(2-thienyl) piperidine ([3H]-TCP) binding to PCP receptor ChEMBL. 2542555

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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